TDMS Study 05040-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: American Biogenics DATE: 09/05/94
EXP: 05040 HYDROQUINONE TIME: 10:32:14
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 55834B
CONT: CAS: 000123319
PATHOLOGIST: K. SMITH S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: American Biogenics DATE: 09/05/94
EXP: 05040 HYDROQUINONE TIME: 10:32:14
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 55834B
CONT: CAS: 000123319
PATHOLOGIST: K. SMITH S. EUSTIS
HYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 65 UNCENSORED DEATHS 26 CENSORED DEATHS 12 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 367 381 459 483 515 546 560 567 593 596 |
| 602 602 616 637 646 654 665 676 681 683 |
| 702 713 715 729 730 730 |
| CENSORED DEATHS |
| 273 459 459 459 459 459 459 459 459 459 |
| 459 710 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 25 MG/KG |
| --------------------- |
| |
| TOTAL 65 UNCENSORED DEATHS 32 CENSORED DEATHS 15 TERMINAL 18 |
| |
| UNCENSORED DEATHS |
| 207 263 392 466 490 536 540 576 583 599 |
| 610 612 617 625 632 638 653 655 656 659 |
| 662 673 686 689 703 709 713 718 723 728 |
| 728 728 |
| CENSORED DEATHS |
| 86 429 431 459 459 459 459 459 459 459 |
| 459 459 459 651 668 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/KG |
| --------------------- |
| |
| TOTAL 65 UNCENSORED DEATHS 30 CENSORED DEATHS 17 TERMINAL 18 |
| |
| UNCENSORED DEATHS |
| 501 522 554 556 562 581 597 598 606 606 |
| 612 612 631 637 638 651 659 672 672 672 |
| 676 686 689 700 702 710 711 718 718 720 |
| CENSORED DEATHS |
| 318 459 459 459 459 459 459 459 459 459 |
| 459 473 648 669 682 700 707 |
| |
==================================================================================
HYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 731 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 731 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 96.9 93.4 91.6 78.5 69.1 52.0 |
|CONTROL | |
| | |
|25 MG/KG | 100.0 100.0 96.9 96.9 95.3 93.4 87.5 81.7 60.0 37.3 |
| | |
| | |
|50 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 96.2 84.9 67.8 40.3 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 25 MG/KG 50 MG/KG |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 52.0% 37.3% 40.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.371 P=0.217 P=0.427 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 609.5 608.4 639.0 |
|NATURAL DEATHS (C) | (20.1) (22.5) (11.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 633.2 607.4 632.5 |
|(STANDARD ERROR) | (15.3) (17.9) (13.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
HYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 65 UNCENSORED DEATHS 15 CENSORED DEATHS 10 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 372 476 500 501 553 575 646 647 658 674 |
| 685 686 702 710 722 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 25 MG/KG |
| --------------------- |
| |
| TOTAL 65 UNCENSORED DEATHS 25 CENSORED DEATHS 13 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 373 444 487 492 560 576 595 624 625 625 |
| 633 654 655 655 661 667 668 672 672 708 |
| 709 710 719 721 724 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 458 458 458 458 |
| 700 700 700 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/KG |
| --------------------- |
| |
| TOTAL 65 UNCENSORED DEATHS 20 CENSORED DEATHS 13 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 458 492 588 590 597 598 634 638 652 658 |
| 669 676 687 694 695 703 707 711 714 716 |
| CENSORED DEATHS |
| 343 458 458 458 458 458 458 458 458 458 |
| 458 658 658 |
| |
==================================================================================
HYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 98.5 96.6 93.0 89.3 83.9 72.9 |
|CONTROL | |
| | |
|25 MG/KG | 100.0 100.0 100.0 100.0 98.5 96.9 93.3 87.8 73.1 53.9 |
| | |
| | |
|50 MG/KG | 100.0 100.0 100.0 100.0 100.0 98.4 96.6 89.2 81.7 62.3 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 25 MG/KG 50 MG/KG |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 72.9% 53.9% 62.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.350 P=0.067 P=0.380 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 607.1 625.2 643.9 |
|NATURAL DEATHS (C) | (27.1) (18.3) (16.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 659.2 646.0 653.0 |
|(STANDARD ERROR) | (13.8) (13.5) (13.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
HYDROQUINONE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
25 MG/KG = 2
50 MG/KG = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1 3
| 2 2 1 12 1 3 3
| 2 12 1 3 3
| 2 12 1 21 33
90 + 21 13 3
| 2 11 2 3
P | 1 22 113
E | 2 2 2
R 80 + 33
C | 1 12 1
E | 221 1
N | 2211
T 70 + 231 1 1
| 3311
S | 2 2
U | 331 11
R 60 + 2 23 11
V | 223 1 1
I | 2232
V | 322 1
A 50 +
L | 22
| 22
|
40 + 3 3
| 2 2
|
|
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 34 obs hidden.
HYDROQUINONE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
25 MG/KG = 2
50 MG/KG = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3
| 1 2 3 1 3
| 2 2
| 1 31 3
95 + 22 3 3
| 2 2
| 1 1 33
| 12 1
90 + 2 2
| 1 3 3 1
| 2 233
| 11
P 85 + 3 3
E | 1 1
R | 22 11
C | 3 3
E 80 + 2 2 33
N | 1 1
T | 3 3
| 3311
S 75 + 2 2 1 1
U | 22
R | 33 1 1
V |
I 70 +
V |
A | 33
L | 2 2
65 +
| 33
| 3 3
|
60 + 22
|
|
| 22
55 +
| 2 2
|
|
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.
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