TDMS Study 05043-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
2,4-DIAMINOPHENOL DIHYDROCHLORIDE
NTP Experiment-Test: 05043-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/05/94
Route: GAVAGE Time: 18:59:58
Facility: TSI Mason Research
Chemical CAS #: 137-09-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05043-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 18:59:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE .019 G/ .038 /G
72VF KG 72LF KG 72HF
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 11 12 20
Dead 5 7 2
Survivors
Terminal Sacrifice 34 31 28
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (43) (10) (45)
Serosa, Inflammation, Suppurative 3 (7%) 1 (10%)
Intestine Small, Duodenum (48) (48) (48)
Lamina Propria, Congestion, Diffuse 1 (2%)
Lamina Propria, Pigmentation 44 (92%) 47 (98%)
Intestine Small, Jejunum (50) (11) (50)
Lamina Propria, Congestion, Diffuse 1 (2%)
Liver (50) (50) (50)
Abscess, Single 1 (2%)
Angiectasis 1 (2%) 1 (2%)
Basophilic Focus 1 (2%) 3 (6%)
Clear Cell Focus 1 (2%) 1 (2%)
Eosinophilic Focus 1 (2%)
Fatty Change 1 (2%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 4 (8%) 5 (10%) 5 (10%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Inflammation, Chronic 9 (18%) 2 (4%) 8 (16%)
Necrosis 1 (2%) 1 (2%)
Kupffer Cell, Pigmentation 31 (62%) 50 (100%)
Serosa, Inflammation, Suppurative 2 (4%) 1 (2%)
Serosa, Inflammation, Membranous 1 (2%)
Mesentery (7) (4) (4)
Inflammation, Acute 1 (14%)
Inflammation, Chronic 3 (43%) 1 (25%)
Inflammation, Chronic Active 1 (25%)
Inflammation, Suppurative 2 (50%) 1 (25%)
Fat, Necrosis 1 (14%) 1 (25%) 1 (25%)
Mesothelium, Inflammation, Membranous 1 (14%)
Pancreas (50) (14) (49)
Atrophy 1 (7%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic 4 (8%) 2 (14%) 6 (12%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05043-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 18:59:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE .019 G/ .038 /G
72VF KG 72LF KG 72HF
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Suppurative 1 (2%)
Acinus, Atrophy 1 (2%)
Duct, Cyst 1 (2%)
Duct, Interlobular, Ectasia 1 (7%)
Interlobular, Inflammation, Acute 1 (2%)
Serosa, Inflammation, Suppurative 1 (2%)
Serosa, Interlobular, Inflammation,
Suppurative 1 (2%)
Salivary Glands (49) (11) (49)
Inflammation, Chronic 23 (47%) 7 (64%) 18 (37%)
Artery, Inflammation, Chronic, Necrotizing 1 (2%)
Stomach (49) (20) (50)
Serosa, Inflammation, Suppurative 1 (2%)
Stomach, Forestomach (49) (20) (50)
Acanthosis 10 (20%) 9 (45%) 12 (24%)
Inflammation, Acute, Focal 2 (4%) 1 (5%) 2 (4%)
Inflammation, Chronic 1 (2%) 3 (6%)
Ulcer 2 (4%) 5 (25%) 3 (6%)
Stomach, Glandular (49) (15) (50)
Inflammation, Chronic 1 (2%)
Pigmentation 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (12) (50)
Hyperplasia, Lymphoid 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Coronary Artery, Inflammation, Acute 1 (2%)
Myocardium, Inflammation, Acute 1 (2%)
Pericardium, Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (14) (50)
Capsule, Inflammation, Suppurative 1 (7%)
Capsule, Inflammation, Membranous 1 (2%)
Adrenal Gland, Cortex (49) (13) (50)
Congestion 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Capsule, Inflammation 1 (8%)
Parathyroid Gland (30) (9) (30)
Cyst 1 (3%)
Pituitary Gland (46) (13) (44)
Pars Distalis, Hyperplasia 3 (7%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05043-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 18:59:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE .019 G/ .038 /G
72VF KG 72LF KG 72HF
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Hyperplasia, Focal 2 (4%) 1 (2%)
Thyroid Gland (50) (13) (50)
Inflammation, Chronic 2 (4%)
Follicular Cell, Hyperplasia 2 (4%) 1 (8%) 4 (8%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1)
Necrosis 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (48) (25) (44)
Cyst 14 (29%) 8 (32%) 6 (14%)
Cyst, Multiple 1 (2%)
Hyperplasia, Cystic, Papillary 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 6 (13%) 6 (24%) 5 (11%)
Bilateral, Inflammation, Suppurative 2 (4%) 2 (5%)
Follicle, Cyst 5 (10%) 1 (2%)
Periovarian Tissue, Inflammation, Chronic 2 (4%) 1 (4%) 3 (7%)
Periovarian Tissue, Inflammation, Suppurative 1 (2%)
Periovarian Tissue, Necrosis 1 (2%)
Oviduct (2) (6) (9)
Inflammation, Suppurative 1 (17%) 1 (11%)
Uterus (50) (26) (49)
Hydrometra 1 (4%) 3 (6%)
Endometrium, Hemorrhage 1 (4%)
Endometrium, Hyperplasia, Cystic 30 (60%) 15 (58%) 23 (47%)
Endometrium, Inflammation, Suppurative 8 (16%) 1 (4%) 9 (18%)
Muscularis, Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (12) (50)
Hyperplasia 1 (2%)
Myelofibrosis 1 (2%) 4 (8%)
Myeloid Cell, Hyperplasia 1 (2%) 1 (8%) 3 (6%)
Lymph Node (47) (27) (49)
Lumbar, Hematopoietic Cell Proliferation 1 (4%)
Lumbar, Hyperplasia, Lymphoid 1 (4%)
Lumbar, Hyperplasia, Plasma Cell 2 (4%) 2 (4%)
Mandibular, Hyperplasia, Plasma Cell 1 (4%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05043-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 18:59:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE .019 G/ .038 /G
72VF KG 72LF KG 72HF
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Mediastinal, Hematopoietic Cell Proliferation 1 (4%)
Mediastinal, Hyperplasia, Plasma Cell 2 (4%) 1 (4%) 1 (2%)
Mediastinal, Inflammation, Acute 2 (4%)
Pancreatic, Hyperplasia, Lymphoid 1 (2%)
Pancreatic, Pigmentation 5 (10%)
Renal, Hyperplasia, Lymphoid 1 (2%) 2 (7%) 1 (2%)
Renal, Hyperplasia, Plasma Cell 2 (4%) 2 (7%) 1 (2%)
Lymph Node, Mesenteric (46) (23) (46)
Congestion 2 (4%)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Plasma Cell 1 (2%) 1 (4%)
Inflammation, Suppurative 1 (4%)
Pigmentation 1 (2%) 4 (17%) 8 (17%)
Serosa, Inflammation, Membranous 1 (2%)
Spleen (50) (24) (50)
Hematopoietic Cell Proliferation 8 (16%) 9 (38%) 13 (26%)
Hyperplasia, Lymphoid 4 (8%) 1 (4%) 3 (6%)
Metaplasia 1 (2%)
Pigmentation 1 (2%) 1 (2%)
Subcapsular, Inflammation, Acute 1 (2%)
Thymus (33) (10) (39)
Inflammation 1 (10%)
Thymocyte, Necrosis 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (36) (10) (37)
Hyperplasia 1 (10%)
Hyperplasia, Cystic 3 (8%)
Hyperplasia, Lymphoid 1 (3%)
Inflammation, Chronic 1 (3%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (12) (50)
Joint, Tarsal, Hyperostosis 1 (2%)
Skeletal Muscle (3) (1)
Abdominal, Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05043-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 18:59:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE .019 G/ .038 /G
72VF KG 72LF KG 72HF
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (12) (50)
Cerebellum, Abscess, Multiple 1 (2%)
Meninges, Inflammation, Acute 1 (2%)
Meninges, Inflammation, Chronic 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (20) (50)
Congestion 1 (5%) 1 (2%)
Edema 1 (5%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Acute, Focal 1 (5%)
Inflammation, Chronic 1 (2%) 1 (5%) 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%) 1 (5%)
Alveolus, Hyperplasia, Macrophage 1 (2%)
Lymphatic, Perivascular, Inflammation, Acute 1 (2%)
Mediastinum, Inflammation, Suppurative 1 (2%)
Peribronchiolar, Inflammation, Chronic 2 (4%)
Peribronchiolar, Perivascular, Inflammation,
Chronic 2 (4%)
Perivascular, Inflammation, Acute 1 (2%)
Perivascular, Inflammation, Chronic 1 (2%)
Pleura, Inflammation, Chronic 1 (2%)
Pleura, Inflammation, Suppurative 1 (5%) 1 (2%)
Nose (45) (11) (46)
Inflammation, Suppurative 2 (18%) 1 (2%)
Mucosa, Inflammation, Chronic 1 (9%) 2 (4%)
Mucosa, Inflammation, Suppurative 5 (11%)
Nasolacrimal Duct, Inflammation, Chronic 1 (2%)
Turbinate, Inflammation, Chronic 1 (9%) 1 (2%)
Turbinate, Inflammation, Suppurative 1 (9%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (39) (50)
Amyloid Deposition 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic 27 (54%) 10 (26%) 35 (70%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05043-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 18:59:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE .019 G/ .038 /G
72VF KG 72LF KG 72HF
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Metaplasia 3 (8%) 1 (2%)
Necrosis 2 (4%) 5 (13%) 8 (16%)
Cortex, Abscess, Single 1 (2%)
Fat, Inflammation, Chronic 1 (3%)
Papilla, Mineralization 3 (6%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Dilatation 1 (3%) 1 (2%)
Renal Tubule, Hyperplasia 1 (2%)
Renal Tubule, Mineralization 1 (2%) 1 (2%)
Renal Tubule, Necrosis 1 (2%)
Renal Tubule, Pigmentation 4 (10%) 50 (100%)
Renal Tubule, Regeneration 18 (36%) 24 (62%) 42 (84%)
Urinary Bladder (47) (10) (47)
Artery, Serosa, Inflammation, Chronic 1 (2%)
Serosa, Inflammation, Suppurative 1 (2%)
Submucosa, Inflammation, Chronic 14 (30%) 1 (10%) 15 (32%)
Submucosa, Ulcer, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05043-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 18:59:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE .019 G/ .038 G/
72VM KG 72LM KG 72HM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 14 11 12
Dead 6 6 2
Survivors
Terminal Sacrifice 30 33 36
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (46) (14) (44)
Serosa, Inflammation, Acute 1 (2%)
Intestine Small, Duodenum (47) (49) (48)
Lamina Propria, Pigmentation 48 (98%) 47 (98%)
Intestine Small, Ileum (45) (13) (48)
Hyperplasia, Lymphoid 1 (2%)
Peyer's Patch, Hyperplasia, Neutrophil 1 (8%)
Liver (50) (50) (50)
Angiectasis 1 (2%) 1 (2%)
Cyst 1 (2%)
Fatty Change 2 (4%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 2 (4%) 3 (6%)
Mixed Cell Focus 1 (2%)
Necrosis 4 (8%) 3 (6%)
Kupffer Cell, Pigmentation 44 (88%) 47 (94%)
Mesentery (3) (3)
Necrosis, Multifocal 1 (33%)
Fat, Necrosis, Focal 1 (33%) 1 (33%)
Pancreas (50) (16) (50)
Inflammation, Chronic 3 (6%) 1 (6%) 2 (4%)
Acinus, Atrophy 2 (4%) 2 (4%)
Acinus, Hypertrophy, Focal 1 (2%)
Salivary Glands (50) (15) (50)
Inflammation, Chronic 26 (52%) 7 (47%) 31 (62%)
Inflammation, Suppurative 1 (2%)
Acinus, Atrophy, Focal 1 (2%)
Stomach, Forestomach (50) (23) (50)
Acanthosis 4 (8%) 10 (43%) 13 (26%)
Cyst 1 (4%)
Inflammation, Acute 1 (2%) 5 (10%)
Inflammation, Chronic 1 (2%) 3 (13%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05043-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 18:59:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE .019 G/ .038 G/
72VM KG 72LM KG 72HM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Focal 1 (2%)
Mineralization 1 (2%)
Ulcer 2 (9%) 5 (10%)
Stomach, Glandular (50) (22) (50)
Pigmentation 1 (2%)
Tooth (1) (2)
Peridontal Tissue, Inflammation, Chronic 1 (50%)
Peridontal Tissue, Inflammation, Suppurative 1 (100%)
Pulp, Inflammation, Necrotizing 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Artery, Inflammation, Chronic 1 (100%)
Heart (50) (15) (50)
Coronary Artery, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (15) (50)
Cyst 1 (2%)
Hypertrophy 1 (2%)
Adrenal Gland, Medulla (49) (15) (49)
Hyperplasia 2 (4%) 1 (7%)
Islets, Pancreatic (50) (15) (50)
Hyperplasia 3 (6%)
Parathyroid Gland (33) (8) (33)
Cyst, Multiple 1 (3%)
Pituitary Gland (41) (15) (50)
Pars Distalis, Cyst 1 (2%)
Pars Intermedia, Hyperplasia, Focal 1 (2%)
Thyroid Gland (49) (15) (49)
Follicle, Hyperplasia 1 (2%)
Follicular Cell, Hyperplasia 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05043-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 18:59:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE .019 G/ .038 G/
72VM KG 72LM KG 72HM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (15) (50)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Focal, Granulomatous 1 (7%)
Penis (1) (3)
Inflammation, Chronic Active 1 (33%)
Inflammation, Suppurative 1 (100%) 1 (33%)
Necrosis 1 (33%)
Preputial Gland (4) (8) (6)
Inflammation, Chronic 1 (13%) 2 (33%)
Inflammation, Suppurative 3 (38%) 2 (33%)
Duct, Ectasia 2 (50%) 3 (38%) 2 (33%)
Prostate (50) (15) (46)
Inflammation, Acute 1 (2%) 1 (7%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 5 (10%) 2 (13%) 1 (2%)
Seminal Vesicle (49) (19) (50)
Inflammation, Chronic 1 (2%)
Testes (50) (16) (50)
Inflammation, Suppurative 1 (2%)
Interstitial Cell, Hyperplasia 1 (2%)
Interstitial Tissue, Inflammation,
Suppurative 1 (2%)
Seminiferous Tubule, Degeneration 2 (4%) 1 (6%)
Seminiferous Tubule, Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (15) (50)
Myelofibrosis 1 (2%) 1 (2%)
Myeloid Cell, Hyperplasia 1 (7%)
Lymph Node (44) (36) (49)
Lumbar, Hyperplasia, Plasma Cell 2 (5%) 1 (3%)
Mediastinal, Hyperplasia, Lymphoid 1 (3%)
Pancreatic, Pigmentation 1 (3%) 7 (14%)
Renal, Hyperplasia, Histiocytic 1 (2%)
Lymph Node, Mesenteric (44) (32) (49)
Congestion 6 (14%) 18 (56%) 16 (33%)
Hematopoietic Cell Proliferation 2 (6%)
Hyperplasia, Lymphoid 1 (2%)
Pigmentation 5 (16%) 17 (35%)
Spleen (50) (19) (50)
Angiectasis 1 (2%)
Hematopoietic Cell Proliferation 3 (6%) 4 (21%) 5 (10%)
Hyperplasia, Lymphoid 1 (2%) 1 (5%) 1 (2%)
Pigmentation 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05043-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 18:59:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE .019 G/ .038 G/
72VM KG 72LM KG 72HM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Thymus (29) (11) (31)
Necrosis 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (29) (50)
Inflammation, Chronic 1 (2%) 1 (3%)
Parakeratosis, Multifocal 1 (3%)
Ulcer, Multiple 1 (3%) 1 (2%)
Dermis, Fibrosis 1 (3%) 2 (4%)
Dermis, Inflammation, Chronic 1 (3%)
Dermis, Subcutaneous Tissue, Fibrosis 1 (2%)
Prepuce, Hyperkeratosis 1 (2%)
Prepuce, Inflammation, Suppurative 2 (4%) 2 (7%)
Prepuce, Necrosis, Focal 1 (2%)
Subcutaneous Tissue, Inflammation, Acute 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic 1 (2%)
Subcutaneous Tissue, Inflammation,
Granulomatous 1 (3%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (19) (50)
Hyperostosis 1 (5%) 1 (2%)
Joint, Tarsal, Hyperostosis 7 (14%) 14 (74%) 12 (24%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (19) (50)
Congestion 2 (4%) 1 (5%) 1 (2%)
Hemorrhage 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%)
Peribronchiolar, Perivascular, Inflammation,
Chronic 1 (2%)
Perivascular, Inflammation, Chronic 1 (5%)
Nose (42) (11) (39)
Mucosa, Inflammation, Suppurative 1 (2%)
Nasolacrimal Duct, Hyperplasia, Squamous 1 (3%)
Nasolacrimal Duct, Inflammation, Chronic 2 (5%) 1 (9%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05043-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 18:59:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE .019 G/ .038 G/
72VM KG 72LM KG 72HM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1) (1)
Cataract 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (48) (50)
Inflammation, Chronic 26 (52%) 16 (33%) 38 (76%)
Metaplasia 1 (2%)
Metaplasia, Osseous 1 (2%) 1 (2%)
Necrosis 12 (25%) 30 (60%)
Nephropathy 1 (2%)
Cortex, Inflammation, Suppurative 1 (2%)
Papilla, Necrosis 1 (2%) 1 (2%)
Pelvis, Inflammation, Acute 1 (2%)
Renal Tubule, Calculus Micro Observation Only 1 (2%)
Renal Tubule, Dilatation 1 (2%) 15 (31%) 46 (92%)
Renal Tubule, Hyperplasia 3 (6%)
Renal Tubule, Mineralization 2 (4%) 8 (16%)
Renal Tubule, Pigmentation 8 (17%) 47 (94%)
Renal Tubule, Regeneration 34 (68%) 34 (71%) 48 (96%)
Urethra (1)
Mucosa, Lumen, Inflammation, Suppurative 1 (100%)
Urinary Bladder (47) (15) (50)
Concretion 1 (2%)
Mucosa, Inflammation, Acute 1 (2%)
Mucosa, Inflammation, Subacute 1 (7%)
Mucosa, Necrosis 1 (2%) 1 (7%)
Serosa, Inflammation 1 (2%)
Serosa, Inflammation, Acute 1 (2%)
Submucosa, Hemorrhage 1 (2%)
Submucosa, Inflammation, Chronic 3 (6%) 6 (12%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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