TDMS Study 05043-02 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
2,4-DIAMINOPHENOL DIHYDROCHLORIDE
NTP Experiment-Test: 05043-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/05/94
Route: GAVAGE Time: 19:00:01
Facility: TSI Mason Research
Chemical CAS #: 137-09-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05043-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 19:00:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE .019 G/ .038 /G
72VF KG 72LF KG 72HF
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 11 12 20
Dead 5 7 2
Survivors
Terminal Sacrifice 34 31 28
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (43) (10) (45)
Intestine Large, Cecum (49) (11) (50)
Intestine Small, Ileum (49) (11) (49)
Liver (50) (50) (50)
Hemangioma 1 (2%)
Hepatocellular Carcinoma 1 (2%) 4 (8%)
Hepatocellular Adenoma 3 (6%) 3 (6%) 3 (6%)
Histiocytic Sarcoma 1 (2%)
Mesentery (7) (4) (4)
Histiocytic Sarcoma 1 (25%)
Pancreas (50) (14) (49)
Histiocytic Sarcoma 1 (2%)
Salivary Glands (49) (11) (49)
Histiocytic Sarcoma 1 (2%)
Stomach, Forestomach (49) (20) (50)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 2 (10%) 3 (6%)
Stomach, Glandular (49) (15) (50)
Squamous Cell Carcinoma, Deep Invasion 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (12) (50)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05043-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 19:00:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE .019 G/ .038 /G
72VF KG 72LF KG 72HF
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (14) (50)
Adrenal Gland, Medulla (46) (12) (44)
Pheochromocytoma Benign 1 (8%)
Pituitary Gland (46) (13) (44)
Pars Distalis, Adenoma 7 (15%) 3 (23%) 4 (9%)
Thyroid Gland (50) (13) (50)
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GENERAL BODY SYSTEM
Tissue NOS (1) (1)
Fibrosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (48) (25) (44)
Cystadenoma, Papillary 1 (2%)
Histiocytic Sarcoma 1 (2%)
Luteoma 1 (4%) 1 (2%)
Teratoma 1 (4%)
Uterus (50) (26) (49)
Hemangioma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Endometrium, Polyp Stromal 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (12) (50)
Lymph Node (47) (27) (49)
Axillary, Histiocytic Sarcoma 1 (2%)
Inguinal, Histiocytic Sarcoma 1 (2%)
Lumbar, Histiocytic Sarcoma 1 (2%) 1 (4%)
Mandibular, Histiocytic Sarcoma 1 (2%)
Mediastinal, Histiocytic Sarcoma 1 (2%)
Renal, Histiocytic Sarcoma 1 (2%) 1 (4%)
Lymph Node, Mesenteric (46) (23) (46)
Histiocytic Sarcoma 1 (2%) 1 (4%)
Spleen (50) (24) (50)
Hemangiosarcoma 1 (4%)
Histiocytic Sarcoma 1 (2%)
Thymus (33) (10) (39)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05043-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 19:00:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE .019 G/ .038 /G
72VF KG 72LF KG 72HF
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (36) (10) (37)
Carcinoma 1 (3%) 2 (20%)
Skin (50) (31) (49)
Fibrosarcoma 1 (3%) 1 (2%)
Fibrosarcoma, Multiple 1 (3%)
Subcutaneous Tissue, Sarcoma 1 (3%)
Vulva, Squamous Cell Carcinoma, Noninvasive 1 (3%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (3) (1)
Head, Sarcoma 1 (33%)
Hindlimb, Rhabdomyoma 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (20) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (5%) 3 (6%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 4 (20%)
Histiocytic Sarcoma 1 (2%)
Mediastinum, Hemangioma 1 (2%)
Nose (45) (11) (46)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (2) (1) (1)
Adenoma 1 (50%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (39) (50)
Histiocytic Sarcoma 1 (2%)
Renal Tubule, Carcinoma 1 (3%)
Urinary Bladder (47) (10) (47)
Page 4
NTP Experiment-Test: 05043-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 19:00:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE .019 G/ .038 /G
72VF KG 72LF KG 72HF
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Lymphoma Malignant Histiocytic 3 (6%)
Lymphoma Malignant Lymphocytic 5 (10%) 2 (4%) 1 (2%)
Lymphoma Malignant Mixed 4 (8%) 4 (8%) 5 (10%)
Lymphoma Malignant Undifferentiated Cell 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05043-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 19:00:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE .019 G/ .038 /G
72VF KG 72LF KG 72HF
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 24 29 17
Total Primary Neoplasms 34 41 26
Total Animals with Benign Neoplasms 14 12 13
Total Benign Neoplasms 15 14 18
Total Animals with Malignant Neoplasms 15 21 8
Total Malignant Neoplasms 19 27 8
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05043-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 19:00:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE .019 G/ .038 G/
72VM KG 72LM KG 72HM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 14 11 12
Dead 6 6 2
Survivors
Terminal Sacrifice 30 33 36
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (46) (14) (44)
Intestine Small, Duodenum (47) (49) (48)
Histiocytic Sarcoma 1 (2%)
Intestine Small, Ileum (45) (13) (48)
Intestine Small, Jejunum (46) (14) (48)
Liver (50) (50) (50)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%)
Hemangiosarcoma, Metastatic 1 (2%)
Hepatocellular Carcinoma 5 (10%) 5 (10%) 3 (6%)
Hepatocellular Carcinoma, Multiple 1 (2%)
Hepatocellular Adenoma 11 (22%) 14 (28%) 5 (10%)
Histiocytic Sarcoma 1 (2%)
Mesentery (3) (3)
Pancreas (50) (16) (50)
Stomach, Forestomach (50) (23) (50)
Squamous Cell Papilloma 2 (4%) 1 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (15) (50)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Adrenal Gland, Medulla (49) (15) (49)
Pheochromocytoma Benign 2 (4%) 2 (4%)
Page 7
NTP Experiment-Test: 05043-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 19:00:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE .019 G/ .038 G/
72VM KG 72LM KG 72HM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Thyroid Gland (49) (15) (49)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Testes (50) (16) (50)
Interstitial Cell, Adenoma 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (15) (50)
Hemangiosarcoma, Metastatic 1 (7%)
Lymph Node (44) (36) (49)
Mandibular, Carcinoma, Metastatic, Harderian
Gland 1 (3%)
Mediastinal, Histiocytic Sarcoma 1 (2%)
Lymph Node, Mesenteric (44) (32) (49)
Histiocytic Sarcoma 1 (2%)
Spleen (50) (19) (50)
Hemangioma 1 (2%)
Hemangiosarcoma 2 (4%) 1 (5%)
Histiocytic Sarcoma 1 (2%)
Thymus (29) (11) (31)
Thymoma Benign 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (29) (50)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Fibrosarcoma 1 (2%) 3 (10%) 4 (8%)
Fibrosarcoma, Multiple 1 (2%)
Hemangiosarcoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Sarcoma, Poorly
Differentiated 1 (2%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05043-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 19:00:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE .019 G/ .038 G/
72VM KG 72LM KG 72HM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1)
Hemangiosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (19) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 2 (11%) 7 (14%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (5%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (5%)
Carcinoma, Metastatic, Harderian Gland 1 (2%) 1 (5%)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
Schwannoma Malignant 1 (100%)
Harderian Gland (2) (1) (1)
Adenoma 1 (50%) 1 (100%)
Carcinoma 1 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (48) (50)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Renal Tubule, Adenoma 3 (6%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Lymphoma Malignant Lymphocytic 3 (6%) 2 (4%) 3 (6%)
Lymphoma Malignant Mixed 1 (2%) 1 (2%)
* Number of animals with any tissue examined microscopically
Page 9
NTP Experiment-Test: 05043-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 19:00:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE .019 G/ .038 G/
72VM KG 72LM KG 72HM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(50) *(50) *(50)
Lymphoma Malignant Undifferentiated Cell 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 05043-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 19:00:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE .019 G/ .038 G/
72VM KG 72LM KG 72HM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 30 27 31
Total Primary Neoplasms 41 35 39
Total Animals with Benign Neoplasms 17 15 20
Total Benign Neoplasms 21 18 23
Total Animals with Malignant Neoplasms 17 15 16
Total Malignant Neoplasms 20 17 16
Total Animals with Metastatic Neoplasms 4 2 3
Total Metastatic Neoplasm 5 4 5
Total Animals with Malignant Neoplasms 1 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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