TDMS Study 05043-02 Pathology Tables
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
Facility: TSI Mason Research
Chemical CAS #: 137-09-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 5| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 4| 4| 3| 3| 5| 3| 3| 3| 5| 5| 3| 2| 3| 3| 2| 2| 1| 3| 5| 3| 3| 2|
| 1| 1| 9| 0| 2| 2| 2| 6| 1| 1| 2| 3| 3| 1| 2| 2| 2| 9| 9| 0| 2| 3| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Gallbladder | M + + + + + + + M + + + + + M + + A + + + +|
Serosa, Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | |
Clear Cell Focus | |
Eosinophilic Focus | 2 |
Fatty Change | |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic | 2 1 1 2 2 2 |
Necrosis | |
Serosa, Inflammation, Suppurative | |
Serosa, Inflammation, Membranous | |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Acute | 3 |
Inflammation, Chronic | 3 2 |
Fat, Necrosis | |
Mesothelium, Inflammation, Membranous| |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | |
Serosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 2 2 2 2|
__________________________________________________________________________|
Stomach | + + + + M + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 4 4 2 4 4 3 |
Inflammation, Acute, Focal | 2 |
Inflammation, Chronic | 2 |
Ulcer | 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 5| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 4| 4| 3| 3| 5| 3| 3| 3| 5| 5| 3| 2| 3| 3| 2| 2| 1| 3| 5| 3| 3| 2|
| 1| 1| 9| 0| 2| 2| 2| 6| 1| 1| 2| 3| 3| 1| 2| 2| 2| 9| 9| 0| 2| 3| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Pigmentation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Coronary Artery, Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Inflammation, Membranous | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + M + + + + + + + + + M + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + M M + + + + M + + M + + + M M + + + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 3 |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Necrosis | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + I + + + + + + + + + +|
Cyst | X X X X X X |
Cyst, Multiple | X |
Hyperplasia, Cystic, Papillary | 4 |
Hyperplasia, Lymphoid | |
Inflammation, Suppurative | 4 |
Bilateral, Inflammation, Suppurative | 4 |
Follicle, Cyst | X |
Periovarian Tissue, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 2 2 3 3 3 4 4 3 3 3 2 3 |
Endometrium, Inflammation, | |
Suppurative | 2 3 4 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 5| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 4| 4| 3| 3| 5| 3| 3| 3| 5| 5| 3| 2| 3| 3| 2| 2| 1| 3| 5| 3| 3| 2|
| 1| 1| 9| 0| 2| 2| 2| 6| 1| 1| 2| 3| 3| 1| 2| 2| 2| 9| 9| 0| 2| 3| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
Myelofibrosis | 2 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + M + + + + + + + + + + + + + + + + + + + +|
Lumbar, Hyperplasia, Plasma Cell | |
Mediastinal, Hyperplasia, Plasma Cell| |
Mediastinal, Inflammation, Acute | |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 3 |
Pigmentation | |
Serosa, Inflammation, Membranous | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 3 |
Hyperplasia, Lymphoid | 3 3 |
Pigmentation | |
Subcapsular, Inflammation, Acute | |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + M + M + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M + + + + + M M + M + M M M + + + + +|
Hyperplasia, Cystic | 3|
Hyperplasia, Lymphoid | |
Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Chronic | 2 |
Alveolar Epithelium, Hyperplasia, | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 5| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 4| 4| 3| 3| 5| 3| 3| 3| 5| 5| 3| 2| 3| 3| 2| 2| 1| 3| 5| 3| 3| 2|
| 1| 1| 9| 0| 2| 2| 2| 6| 1| 1| 2| 3| 3| 1| 2| 2| 2| 9| 9| 0| 2| 3| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Focal | |
Alveolus, Hyperplasia, Macrophage | |
Lymphatic, Perivascular, | |
Inflammation, Acute | |
Peribronchiolar, Inflammation, | |
Chronic | 3 2 |
Peribronchiolar, Perivascular, | |
Inflammation, Chronic | |
Perivascular, Inflammation, Acute | 4 |
Perivascular, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + M M M + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Acute | |
Inflammation, Chronic | 2 1 2 2 2 2 2 2 2 2 3 3 1 |
Necrosis | 2 3 |
Papilla, Necrosis | 3 |
Renal Tubule, Mineralization | 2 |
Renal Tubule, Regeneration | 1 1 1 3 1 1 2 2 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Suppurative | |
Submucosa, Inflammation, Chronic | 2 1 1 2 1 2 1 |
Submucosa, Ulcer, Chronic | 4 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 3| 4| 4| 4| 3| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 7| 6| 7| 7| 4| 6| 7|
DAY ON TEST | 2| 5| 0| 5| 7| 3| 3| 5| 3| 2| 3| 3| 5| 5| 3| 3| 3| 5| 2| 7| 3| 3| 5| 2| 2|
| 1| 8| 0| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 2| 2| 3| 6| 0| 2| 2| 3| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M M + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Suppurative | 4 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 3 |
Clear Cell Focus | X |
Eosinophilic Focus | |
Fatty Change | |
Hematopoietic Cell Proliferation | 3 4 4 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic | 2 2 2|
Necrosis | 3 |
Serosa, Inflammation, Suppurative | 4 3 |
Serosa, Inflammation, Membranous | 3 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Acute | |
Inflammation, Chronic | 3 |
Fat, Necrosis | |
Mesothelium, Inflammation, Membranous| 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic | 1 |
Inflammation, Suppurative | 4 |
Serosa, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + M + +|
Inflammation, Chronic | 2 1 2 2 2 2 2 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 2 3 |
Inflammation, Acute, Focal | 3 |
Inflammation, Chronic | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 3| 4| 4| 4| 3| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 7| 6| 7| 7| 4| 6| 7|
DAY ON TEST | 2| 5| 0| 5| 7| 3| 3| 5| 3| 2| 3| 3| 5| 5| 3| 3| 3| 5| 2| 7| 3| 3| 5| 2| 2|
| 1| 8| 0| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 2| 2| 3| 6| 0| 2| 2| 3| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Pigmentation | 1 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Coronary Artery, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
Capsule, Inflammation, Membranous | 4 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + M + + M + M M M + M M M M + M|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | M + M + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 3 |
Pars Distalis, Hyperplasia | 4 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Necrosis | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + +|
Cyst | X X X|
Cyst, Multiple | |
Hyperplasia, Cystic, Papillary | |
Hyperplasia, Lymphoid | 2 |
Inflammation, Suppurative | 4 4 2 4 4 |
Bilateral, Inflammation, Suppurative | 4 |
Follicle, Cyst | X X X X |
Periovarian Tissue, Inflammation, | |
Chronic | 3 |
__________________________________________________________________________|
Oviduct | + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 4 2 4 3 4 4 3 4 3 3 4|
Endometrium, Inflammation, | |
Suppurative | 3 4 2 3 4 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 3| 4| 4| 4| 3| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 7| 6| 7| 7| 4| 6| 7|
DAY ON TEST | 2| 5| 0| 5| 7| 3| 3| 5| 3| 2| 3| 3| 5| 5| 3| 3| 3| 5| 2| 7| 3| 3| 5| 2| 2|
| 1| 8| 0| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 2| 2| 3| 6| 0| 2| 2| 3| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + M + + + + + + + + + + + + + + + +|
Hyperplasia | |
Myelofibrosis | |
Myeloid Cell, Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node | + + + M + + + + + + + M + + + + + + +|
Lumbar, Hyperplasia, Plasma Cell | 4 4 |
Mediastinal, Hyperplasia, Plasma Cell| 4 4 |
Mediastinal, Inflammation, Acute | 2 4 |
Pancreatic, Hyperplasia, Lymphoid | 2 |
Renal, Hyperplasia, Lymphoid | 2 |
Renal, Hyperplasia, Plasma Cell | 4 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + M + M + + + + +|
Hyperplasia, Plasma Cell | |
Pigmentation | 1 |
Serosa, Inflammation, Membranous | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 4 3 3 |
Hyperplasia, Lymphoid | 2 3 |
Pigmentation | 2 |
Subcapsular, Inflammation, Acute | |
__________________________________________________________________________|
Thymus | M + + M + + + M + M + + + M + M + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M M + M + M + +|
Hyperplasia, Cystic | 3 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Meninges, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia, | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 3| 4| 4| 4| 3| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 7| 6| 7| 7| 4| 6| 7|
DAY ON TEST | 2| 5| 0| 5| 7| 3| 3| 5| 3| 2| 3| 3| 5| 5| 3| 3| 3| 5| 2| 7| 3| 3| 5| 2| 2|
| 1| 8| 0| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 2| 2| 3| 6| 0| 2| 2| 3| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Focal | 2 |
Alveolus, Hyperplasia, Macrophage | |
Lymphatic, Perivascular, | |
Inflammation, Acute | 3 |
Peribronchiolar, Inflammation, | |
Chronic | |
Peribronchiolar, Perivascular, | |
Inflammation, Chronic | 2 |
Perivascular, Inflammation, Acute | |
Perivascular, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Nose | M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 2 1 2 1 2 1 2 1|
Necrosis | |
Papilla, Necrosis | |
Renal Tubule, Mineralization | |
Renal Tubule, Regeneration | 1 3 2|
__________________________________________________________________________|
Urinary Bladder | M + M + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Suppurative | 3 |
Submucosa, Inflammation, Chronic | 2 3 2 2 1 2 |
Submucosa, Ulcer, Chronic | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 5| 4| | |
DAY ON TEST | 3| 3| 3| 5| 3| 0| 3| 3| 5| 5| | |
| 3| 3| 3| 3| 3| 5| 3| 2| 8| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + M + + + + | 48 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + + + + + | 43 |
Serosa, Inflammation, Suppurative | | 3 3.3|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | M + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + M + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + M + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 50 |
Angiectasis | | 1 3.0|
Basophilic Focus | | 1 3.0|
Clear Cell Focus | | 1 |
Eosinophilic Focus | | 1 2.0|
Fatty Change | 2 | 1 2.0|
Hematopoietic Cell Proliferation | | 4 3.3|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic | | 9 1.8|
Necrosis | | 1 3.0|
Serosa, Inflammation, Suppurative | | 2 3.5|
Serosa, Inflammation, Membranous | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 7 |
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | | 3 2.7|
Fat, Necrosis | 4 | 1 4.0|
Mesothelium, Inflammation, Membranous| | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 50 |
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic | 1 3 | 4 2.0|
Inflammation, Suppurative | | 1 4.0|
Serosa, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 49 |
Inflammation, Chronic | 2 2 2 2 | 23 1.6|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 49 |
Serosa, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 49 |
Acanthosis | | 10 3.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 5| 4| | |
DAY ON TEST | 3| 3| 3| 5| 3| 0| 3| 3| 5| 5| | |
| 3| 3| 3| 3| 3| 5| 3| 2| 8| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Acute, Focal | | 2 2.5|
Inflammation, Chronic | | 1 2.0|
Ulcer | | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 49 |
Inflammation, Chronic | | 1 1.0|
Pigmentation | | 2 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 50 |
Hyperplasia, Lymphoid | | 1 2.0|
Coronary Artery, Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + M + + + + + + + | 49 |
Capsule, Inflammation, Membranous | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + M + + + + + + + | 49 |
Hematopoietic Cell Proliferation | | 1 4.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + M + M + + + + + | 46 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + M + + | 30 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + | 46 |
Pars Distalis, Hyperplasia, Focal | | 2 3.0|
Pars Distalis, Hyperplasia | | 3 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 50 |
Inflammation, Chronic | 1 | 2 1.0|
Follicular Cell, Hyperplasia | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + M + + | 48 |
Cyst | X X X X X | 14 |
Cyst, Multiple | | 1 |
Hyperplasia, Cystic, Papillary | | 1 4.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 5| 4| | |
DAY ON TEST | 3| 3| 3| 5| 3| 0| 3| 3| 5| 5| | |
| 3| 3| 3| 3| 3| 5| 3| 2| 8| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 7 3.7|
Bilateral, Inflammation, Suppurative | | 2 4.0|
Follicle, Cyst | | 5 |
Periovarian Tissue, Inflammation, | | |
Chronic | 3 | 2 3.0|
__________________________________________________________________________|____________|
Oviduct | + | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 50 |
Endometrium, Hyperplasia, Cystic | 4 3 3 3 2 3 2 | 30 3.1|
Endometrium, Inflammation, | | |
Suppurative | | 8 3.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 49 |
Hyperplasia | | 1 4.0|
Myelofibrosis | | 1 2.0|
Myeloid Cell, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 47 |
Lumbar, Hyperplasia, Plasma Cell | | 2 4.0|
Mediastinal, Hyperplasia, Plasma Cell| | 2 4.0|
Mediastinal, Inflammation, Acute | | 2 3.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
Renal, Hyperplasia, Lymphoid | | 1 2.0|
Renal, Hyperplasia, Plasma Cell | | 2 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 46 |
Hyperplasia, Plasma Cell | | 1 3.0|
Pigmentation | | 1 1.0|
Serosa, Inflammation, Membranous | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 50 |
Hematopoietic Cell Proliferation | | 8 3.6|
Hyperplasia, Lymphoid | | 4 2.8|
Pigmentation | | 1 2.0|
Subcapsular, Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M M M + M M M + + | 33 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + M + | 36 |
Hyperplasia, Cystic | 3 | 3 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 5| 4| | |
DAY ON TEST | 3| 3| 3| 5| 3| 0| 3| 3| 5| 5| | |
| 3| 3| 3| 3| 3| 5| 3| 2| 8| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 50 |
Meninges, Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Alveolus, Hyperplasia, Macrophage | 4 | 1 4.0|
Lymphatic, Perivascular, | | |
Inflammation, Acute | | 1 3.0|
Peribronchiolar, Inflammation, | | |
Chronic | | 2 2.5|
Peribronchiolar, Perivascular, | | |
Inflammation, Chronic | 3 | 2 2.5|
Perivascular, Inflammation, Acute | | 1 4.0|
Perivascular, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + M + | 45 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | 1 2 1 2 2 | 27 1.8|
Necrosis | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 5| 4| | |
DAY ON TEST | 3| 3| 3| 5| 3| 0| 3| 3| 5| 5| | |
| 3| 3| 3| 3| 3| 5| 3| 2| 8| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Papilla, Necrosis | | 1 3.0|
Renal Tubule, Mineralization | | 1 2.0|
Renal Tubule, Regeneration | 2 1 1 2 2 | 18 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + M + + + + + + | 47 |
Serosa, Inflammation, Suppurative | | 1 3.0|
Submucosa, Inflammation, Chronic | 1 | 14 1.6|
Submucosa, Ulcer, Chronic | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 0| 7| 5| 7| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 4| 6|
DAY ON TEST | 3| 3| 3| 1| 5| 3| 3| 7| 3| 9| 3| 5| 3| 3| 3| 1| 5| 3| 3| 2| 3| 3| 8| 5| 9|
| 0| 0| 0| 3| 3| 0| 0| 1| 0| 2| 1| 3| 1| 0| 0| 6| 3| 1| 0| 6| 1| 1| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.019 G/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + |
__________________________________________________________________________|
Gallbladder | + + + |
Serosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large | + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + M +|
Lamina Propria, Pigmentation | 1 2 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Intestine Small, Ileum | + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + M + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 3 |
Fatty Change | 3 |
Hematopoietic Cell Proliferation | 2 3 2 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic | 3 |
Kupffer Cell, Pigmentation | 1 1 1 1 1 1 1 1 1 1 |
Serosa, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Suppurative | 3 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + |
Atrophy | |
Inflammation, Chronic | |
Duct, Interlobular, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + M |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + |
Acanthosis | 3 3 2 3 |
Inflammation, Acute, Focal | |
Ulcer | 2 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + |
Capsule, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + |
Capsule, Inflammation | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 0| 7| 5| 7| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 4| 6|
DAY ON TEST | 3| 3| 3| 1| 5| 3| 3| 7| 3| 9| 3| 5| 3| 3| 3| 1| 5| 3| 3| 2| 3| 3| 8| 5| 9|
| 0| 0| 0| 3| 3| 0| 0| 1| 0| 2| 1| 3| 1| 0| 0| 6| 3| 1| 0| 6| 1| 1| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.019 G/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + |
__________________________________________________________________________|
Parathyroid Gland | M + + |
__________________________________________________________________________|
Pituitary Gland | + + + |
__________________________________________________________________________|
Thyroid Gland | + + + |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + |
Cyst | X X X |
Inflammation, Suppurative | 4 4 4 4 |
Periovarian Tissue, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Oviduct | + |
Inflammation, Suppurative | |
__________________________________________________________________________|
Uterus | + + + + + + + + |
Hydrometra | 4 |
Endometrium, Hemorrhage | |
Endometrium, Hyperplasia, Cystic | 3 3 3 4 |
Endometrium, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + M + + + + + |
Lumbar, Hematopoietic Cell | |
Proliferation | |
Lumbar, Hyperplasia, Lymphoid | 2 |
Mandibular, Hyperplasia, Plasma Cell | |
Mediastinal, Hematopoietic Cell | |
Proliferation | |
Mediastinal, Hyperplasia, Plasma Cell| 4 |
Renal, Hyperplasia, Lymphoid | 3 2 |
Renal, Hyperplasia, Plasma Cell | 4 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + |
Hyperplasia, Plasma Cell | |
Inflammation, Suppurative | |
Pigmentation | 1 1 |
__________________________________________________________________________|
Spleen | + + + + |
Hematopoietic Cell Proliferation | 4 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 0| 7| 5| 7| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 4| 6|
DAY ON TEST | 3| 3| 3| 1| 5| 3| 3| 7| 3| 9| 3| 5| 3| 3| 3| 1| 5| 3| 3| 2| 3| 3| 8| 5| 9|
| 0| 0| 0| 3| 3| 0| 0| 1| 0| 2| 1| 3| 1| 0| 0| 6| 3| 1| 0| 6| 1| 1| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.019 G/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + |
Inflammation | 4 |
Thymocyte, Necrosis | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + |
Hyperplasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + |
__________________________________________________________________________|
Skeletal Muscle | |
Abdominal, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + |
Congestion | 3 |
Edema | 3 |
Inflammation, Acute, Focal | 2 |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Pleura, Inflammation, Suppurative | |
__________________________________________________________________________|
Nose | M + + |
Inflammation, Suppurative | |
Mucosa, Inflammation, Chronic | |
Turbinate, Inflammation, Chronic | |
Turbinate, Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 |
Metaplasia | 1 |
Necrosis | 1 2 1 |
Fat, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 0| 7| 5| 7| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 4| 6|
DAY ON TEST | 3| 3| 3| 1| 5| 3| 3| 7| 3| 9| 3| 5| 3| 3| 3| 1| 5| 3| 3| 2| 3| 3| 8| 5| 9|
| 0| 0| 0| 3| 3| 0| 0| 1| 0| 2| 1| 3| 1| 0| 0| 6| 3| 1| 0| 6| 1| 1| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.019 G/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Dilatation | 1 |
Renal Tubule, Pigmentation | 1 1 1 |
Renal Tubule, Regeneration | 1 1 2 1 1 1 2 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + |
Submucosa, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 2| 7| 7| 4| 7| 4| 7| 7| 6| 4| 7| 4| 3| 3| 4| 7| 7| 7| 6|
DAY ON TEST | 0| 3| 3| 3| 5| 6| 5| 3| 3| 5| 3| 5| 3| 0| 1| 5| 3| 7| 3| 3| 5| 3| 3| 3| 3|
| 4| 1| 1| 1| 3| 0| 6| 1| 1| 3| 1| 3| 1| 0| 9| 3| 1| 1| 0| 7| 3| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.019 G/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + +|
__________________________________________________________________________|
Gallbladder | M M + + + +|
Serosa, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Intestine Large | + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M A + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + +|
Lamina Propria, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Fatty Change | |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic | 2 |
Kupffer Cell, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Serosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Suppurative | 4 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + +|
Atrophy | 4 |
Inflammation, Chronic | 1 2|
Duct, Interlobular, Ectasia | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + +|
Inflammation, Chronic | 3 2 1 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + +|
Acanthosis | 3 4 4 3|
Inflammation, Acute, Focal | 2|
Ulcer | 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + +|
Capsule, Inflammation, Suppurative | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + +|
Capsule, Inflammation | 4 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 2| 7| 7| 4| 7| 4| 7| 7| 6| 4| 7| 4| 3| 3| 4| 7| 7| 7| 6|
DAY ON TEST | 0| 3| 3| 3| 5| 6| 5| 3| 3| 5| 3| 5| 3| 0| 1| 5| 3| 7| 3| 3| 5| 3| 3| 3| 3|
| 4| 1| 1| 1| 3| 0| 6| 1| 1| 3| 1| 3| 1| 0| 9| 3| 1| 1| 0| 7| 3| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.019 G/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M + M + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + +|
Follicular Cell, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + +|
Cyst | X X X |
Inflammation, Suppurative | 4 3 |
Periovarian Tissue, Inflammation, | |
Chronic | 4 |
__________________________________________________________________________|
Oviduct | + + + |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + +|
Hydrometra | |
Endometrium, Hemorrhage | 3 |
Endometrium, Hyperplasia, Cystic | 3 2 3 4 3 3 4 4 |
Endometrium, Inflammation, | |
Suppurative | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + +|
Myeloid Cell, Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
Lumbar, Hematopoietic Cell | |
Proliferation | 4 |
Lumbar, Hyperplasia, Lymphoid | |
Mandibular, Hyperplasia, Plasma Cell | 3 |
Mediastinal, Hematopoietic Cell | |
Proliferation | 4 |
Mediastinal, Hyperplasia, Plasma Cell| |
Renal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 4 |
Inflammation, Suppurative | 2 |
Pigmentation | 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 4 4 3 2 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 2| 7| 7| 4| 7| 4| 7| 7| 6| 4| 7| 4| 3| 3| 4| 7| 7| 7| 6|
DAY ON TEST | 0| 3| 3| 3| 5| 6| 5| 3| 3| 5| 3| 5| 3| 0| 1| 5| 3| 7| 3| 3| 5| 3| 3| 3| 3|
| 4| 1| 1| 1| 3| 0| 6| 1| 1| 3| 1| 3| 1| 0| 9| 3| 1| 1| 0| 7| 3| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.019 G/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Thymus | M + M M + + +|
Inflammation | |
Thymocyte, Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Abdominal, Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + +|
Congestion | |
Edema | |
Inflammation, Acute, Focal | |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 |
Pleura, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Nose | + + + + + +|
Inflammation, Suppurative | |
Mucosa, Inflammation, Chronic | |
Turbinate, Inflammation, Chronic | 2 |
Turbinate, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 1 3 2|
Metaplasia | 2 1 |
Necrosis | 2 |
Fat, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 2| 7| 7| 4| 7| 4| 7| 7| 6| 4| 7| 4| 3| 3| 4| 7| 7| 7| 6|
DAY ON TEST | 0| 3| 3| 3| 5| 6| 5| 3| 3| 5| 3| 5| 3| 0| 1| 5| 3| 7| 3| 3| 5| 3| 3| 3| 3|
| 4| 1| 1| 1| 3| 0| 6| 1| 1| 3| 1| 3| 1| 0| 9| 3| 1| 1| 0| 7| 3| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.019 G/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Dilatation | |
Renal Tubule, Pigmentation | 1 |
Renal Tubule, Regeneration | 1 1 1 1 1 2 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + M + + M +|
Submucosa, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 7| 3| 7| 7| 7| 7| 7| 4| 6| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 5| 2| 1| | |
| 1| 0| 1| 1| 1| 1| 1| 3| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
.019 G/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 12 |
__________________________________________________________________________|____________|
Gallbladder | + + + | 10 |
Serosa, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 48 |
Lamina Propria, Pigmentation | 1 1 1 1 1 2 1 1 2 | 44 1.1|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 11 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 50 |
Basophilic Focus | 2 | 3 2.7|
Fatty Change | | 1 3.0|
Hematopoietic Cell Proliferation | 2 | 5 2.2|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic | | 2 2.5|
Kupffer Cell, Pigmentation | 1 1 1 1 1 1 1 | 31 1.0|
Serosa, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Inflammation, Suppurative | | 2 3.5|
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + | 14 |
Atrophy | | 1 4.0|
Inflammation, Chronic | | 2 1.5|
Duct, Interlobular, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + | 11 |
Inflammation, Chronic | 2 2 | 7 2.0|
__________________________________________________________________________|____________|
Stomach | + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 20 |
Acanthosis | 4 | 9 3.2|
Inflammation, Acute, Focal | | 1 2.0|
Ulcer | | 5 2.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 15 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + | 12 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 7| 3| 7| 7| 7| 7| 7| 4| 6| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 5| 2| 1| | |
| 1| 0| 1| 1| 1| 1| 1| 3| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
.019 G/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + | 14 |
Capsule, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + | 13 |
Capsule, Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + | 12 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 12 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M | 9 |
__________________________________________________________________________|____________|
Pituitary Gland | + + M + | 13 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 13 |
Follicular Cell, Hyperplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + | 25 |
Cyst | X X | 8 |
Inflammation, Suppurative | | 6 3.8|
Periovarian Tissue, Inflammation, | | |
Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Oviduct | + + | 6 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + | 26 |
Hydrometra | | 1 4.0|
Endometrium, Hemorrhage | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 3 4 2 | 15 3.2|
Endometrium, Inflammation, | | |
Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 12 |
Myeloid Cell, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 27 |
Lumbar, Hematopoietic Cell | | |
Proliferation | | 1 4.0|
Lumbar, Hyperplasia, Lymphoid | | 1 2.0|
Mandibular, Hyperplasia, Plasma Cell | | 1 3.0|
Mediastinal, Hematopoietic Cell | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 7| 3| 7| 7| 7| 7| 7| 4| 6| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 5| 2| 1| | |
| 1| 0| 1| 1| 1| 1| 1| 3| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
.019 G/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Proliferation | | 1 4.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 4.0|
Renal, Hyperplasia, Lymphoid | | 2 2.5|
Renal, Hyperplasia, Plasma Cell | | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 23 |
Hyperplasia, Plasma Cell | | 1 4.0|
Inflammation, Suppurative | | 1 2.0|
Pigmentation | | 4 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 24 |
Hematopoietic Cell Proliferation | 4 4 | 9 3.7|
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + | 10 |
Inflammation | | 1 4.0|
Thymocyte, Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + | 10 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + M + + + + + | 31 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 12 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Abdominal, Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 12 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + | 20 |
Congestion | | 1 3.0|
Edema | | 1 3.0|
Inflammation, Acute, Focal | | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 3.0|
Pleura, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + | 11 |
Inflammation, Suppurative | 3 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 7| 3| 7| 7| 7| 7| 7| 4| 6| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 5| 2| 1| | |
| 1| 0| 1| 1| 1| 1| 1| 3| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
.019 G/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mucosa, Inflammation, Chronic | 4 | 1 4.0|
Turbinate, Inflammation, Chronic | | 1 2.0|
Turbinate, Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 39 |
Inflammation, Chronic | 2 2 1 | 10 1.7|
Metaplasia | | 3 1.3|
Necrosis | 1 | 5 1.4|
Fat, Inflammation, Chronic | | 1 2.0|
Renal Tubule, Dilatation | | 1 1.0|
Renal Tubule, Pigmentation | | 4 1.0|
Renal Tubule, Regeneration | 2 1 1 1 | 24 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 10 |
Submucosa, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 4| 5| 3| 4| 4| 7| 4| 7| 5| 5| 4| 2| 7| 4| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 4| 4| 5| 3| 5| 3| 9| 1| 5| 4| 3| 5| 3| 1| 3|
| 0| 0| 0| 3| 0| 0| 0| 0| 3| 1| 0| 3| 3| 0| 3| 0| 2| 6| 3| 5| 0| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
.038 G/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
KG 72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + M + + + + + + + + + + + + + + +|
Lamina Propria, Congestion, Diffuse | |
Lamina Propria, Pigmentation | 3 3 2 3 1 2 2 2 2 3 2 2 3 2 1 2 2 2|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
Lamina Propria, Congestion, Diffuse | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Abscess, Single | 3 |
Angiectasis | 3 |
Clear Cell Focus | X |
Fatty Change | 4 |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | 2 2 2|
Necrosis | 2 |
Kupffer Cell, Pigmentation | 2 2 2 2 2 2 3 2 2 4 2 2 3 4 1 2 2 2 2|
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Acinus, Atrophy | |
Duct, Cyst | X |
Interlobular, Inflammation, Acute | |
Serosa, Interlobular, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + M + + + +|
Inflammation, Chronic | 2 2 1 2 |
Artery, Inflammation, Chronic, | |
Necrotizing | 4|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 3 |
Inflammation, Acute, Focal | |
Inflammation, Chronic | |
Ulcer | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 4| 5| 3| 4| 4| 7| 4| 7| 5| 5| 4| 2| 7| 4| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 4| 4| 5| 3| 5| 3| 9| 1| 5| 4| 3| 5| 3| 1| 3|
| 0| 0| 0| 3| 0| 0| 0| 0| 3| 1| 0| 3| 3| 0| 3| 0| 2| 6| 3| 5| 0| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
.038 G/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
KG 72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
Myocardium, Inflammation, Acute | |
Pericardium, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + + M M M + + + M + + + M M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + M M|
Pars Distalis, Hyperplasia, Focal | 2 |
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + +|
Cyst | X X X|
Inflammation, Chronic | 2|
Inflammation, Suppurative | |
Bilateral, Inflammation, Suppurative | |
Follicle, Cyst | |
Periovarian Tissue, Inflammation, | |
Chronic | 3 |
Periovarian Tissue, Inflammation, | |
Suppurative | |
Periovarian Tissue, Necrosis | 3 |
__________________________________________________________________________|
Oviduct | + + + |
Inflammation, Suppurative | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
Hydrometra | 4 4 3 |
Endometrium, Hyperplasia, Cystic | 3 2 4 3 2 3 4 3|
Endometrium, Inflammation, | |
Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 4| 5| 3| 4| 4| 7| 4| 7| 5| 5| 4| 2| 7| 4| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 4| 4| 5| 3| 5| 3| 9| 1| 5| 4| 3| 5| 3| 1| 3|
| 0| 0| 0| 3| 0| 0| 0| 0| 3| 1| 0| 3| 3| 0| 3| 0| 2| 6| 3| 5| 0| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
.038 G/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
KG 72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Muscularis, Inflammation, Suppurative| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 3 2 |
Myeloid Cell, Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + M + +|
Lumbar, Hyperplasia, Plasma Cell | |
Mandibular, Hyperplasia, Plasma Cell | 3 |
Mediastinal, Hyperplasia, Plasma Cell| |
Pancreatic, Pigmentation | 4 2 1 |
Renal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + M + + + + + + + M + +|
Congestion | 4 |
Hyperplasia, Lymphoid | |
Pigmentation | 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Lymphoid | |
Metaplasia | |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + + M M + + + + + + + A + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M M M + + + + M + + + M M + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Cerebellum, Abscess, Multiple | 4 |
Meninges, Inflammation, Acute | |
Meninges, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Chronic | 2 |
Mediastinum, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 4| 5| 3| 4| 4| 7| 4| 7| 5| 5| 4| 2| 7| 4| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 4| 4| 5| 3| 5| 3| 9| 1| 5| 4| 3| 5| 3| 1| 3|
| 0| 0| 0| 3| 0| 0| 0| 0| 3| 1| 0| 3| 3| 0| 3| 0| 2| 6| 3| 5| 0| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
.038 G/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
KG 72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Pleura, Inflammation, Chronic | |
Pleura, Inflammation, Suppurative | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + M + + + M|
Inflammation, Suppurative | |
Mucosa, Inflammation, Chronic | 2 3 |
Mucosa, Inflammation, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 1 |
Turbinate, Inflammation, Chronic | 2 |
Turbinate, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Inflammation, Acute | |
Inflammation, Chronic | 2 3 2 2 2 3 2 2 2 2 2 1 2 2|
Metaplasia | |
Necrosis | 3 2 3 |
Cortex, Abscess, Single | 3 |
Papilla, Mineralization | 2 1 1 |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Mineralization | 2 |
Renal Tubule, Necrosis | 2 |
Renal Tubule, Pigmentation | 1 1 2 2 1 2 1 4 2 3 1 1 2 2 2 2 1 1 2|
Renal Tubule, Regeneration | 1 1 2 2 1 2 1 3 1 3 1 2 2 2 2 1 2|
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + + + + + + M +|
Artery, Serosa, Inflammation, Chronic| 4|
Submucosa, Inflammation, Chronic | 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 2| 3| 3| 7| 7| 6| 7| 6| 6| 7| 6| 4| 7| 4| 4| 6| 2| 7| 4| 4| 7| 7| 6| 6|
DAY ON TEST | 3| 8| 2| 2| 3| 3| 5| 3| 6| 1| 3| 6| 5| 3| 7| 5| 8| 8| 3| 5| 3| 3| 3| 6| 6|
| 0| 8| 7| 7| 0| 0| 9| 0| 2| 4| 0| 2| 3| 0| 9| 3| 8| 8| 0| 3| 0| 0| 0| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
.038 G/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG 72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + + + + + + + + + + + M + + + + + M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
Lamina Propria, Congestion, Diffuse | 4 |
Lamina Propria, Pigmentation | 2 2 2 1 2 2 2 2 2 2 2 3 3 2 2 2 2 1 2 2 2|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +|
Lamina Propria, Congestion, Diffuse | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Abscess, Single | |
Angiectasis | |
Clear Cell Focus | |
Fatty Change | |
Hematopoietic Cell Proliferation | 3 4 3 2 3 |
Inflammation, Chronic | 1 2 2 |
Necrosis | |
Kupffer Cell, Pigmentation | 1 2 2 1 2 2 3 3 2 3 2 2 3 2 2 2 2 3 2 3 3 3|
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | 2 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 1 2 |
Acinus, Atrophy | 3 |
Duct, Cyst | |
Interlobular, Inflammation, Acute | 3 |
Serosa, Interlobular, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 1 2 1 2 2 2 2 1|
Artery, Inflammation, Chronic, | |
Necrotizing | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 4 3 4 4 4 4 |
Inflammation, Acute, Focal | 2 4 |
Inflammation, Chronic | 3 1 |
Ulcer | 2 2 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 2| 3| 3| 7| 7| 6| 7| 6| 6| 7| 6| 4| 7| 4| 4| 6| 2| 7| 4| 4| 7| 7| 6| 6|
DAY ON TEST | 3| 8| 2| 2| 3| 3| 5| 3| 6| 1| 3| 6| 5| 3| 7| 5| 8| 8| 3| 5| 3| 3| 3| 6| 6|
| 0| 8| 7| 7| 0| 0| 9| 0| 2| 4| 0| 2| 3| 0| 9| 3| 8| 8| 0| 3| 0| 0| 0| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
.038 G/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG 72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
Myocardium, Inflammation, Acute | 4 |
Pericardium, Inflammation, | |
Suppurative | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + M M M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M M + + M + + + M M + + + + M + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + +|
Pars Distalis, Hyperplasia, Focal | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | M M M + + + + + + + + + + + + + + + + + + M|
Cyst | X X |
Inflammation, Chronic | |
Inflammation, Suppurative | 4 4 4 4 4 |
Bilateral, Inflammation, Suppurative | 4 4 |
Follicle, Cyst | X |
Periovarian Tissue, Inflammation, | |
Chronic | 3 4 |
Periovarian Tissue, Inflammation, | |
Suppurative | 3 |
Periovarian Tissue, Necrosis | |
__________________________________________________________________________|
Oviduct | + + + + +|
Inflammation, Suppurative | 3|
__________________________________________________________________________|
Uterus | + M + + + + + + + + + + + + + + + + + + + +|
Hydrometra | |
Endometrium, Hyperplasia, Cystic | 4 2 3 3 3 4 3 3 3|
Endometrium, Inflammation, | |
Suppurative | 3 4 3 4 2 3 4 3|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 2| 3| 3| 7| 7| 6| 7| 6| 6| 7| 6| 4| 7| 4| 4| 6| 2| 7| 4| 4| 7| 7| 6| 6|
DAY ON TEST | 3| 8| 2| 2| 3| 3| 5| 3| 6| 1| 3| 6| 5| 3| 7| 5| 8| 8| 3| 5| 3| 3| 3| 6| 6|
| 0| 8| 7| 7| 0| 0| 9| 0| 2| 4| 0| 2| 3| 0| 9| 3| 8| 8| 0| 3| 0| 0| 0| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
.038 G/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG 72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Muscularis, Inflammation, Suppurative| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 |
Myeloid Cell, Hyperplasia | 4 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Hyperplasia, Plasma Cell | 4 4 |
Mandibular, Hyperplasia, Plasma Cell | 4 |
Mediastinal, Hyperplasia, Plasma Cell| 4 |
Pancreatic, Pigmentation | 3 |
Renal, Hyperplasia, Lymphoid | 4 |
Renal, Hyperplasia, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 3 |
Pigmentation | 1 1 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 4 4 4 4 4 3 3 4 4 |
Hyperplasia, Lymphoid | 3 3 4 |
Metaplasia | 2 |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + M M + + + + + + + + + M + + + + M M M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + M + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Abscess, Multiple | |
Meninges, Inflammation, Acute | 4 |
Meninges, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Chronic | |
Mediastinum, Inflammation, | |
Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 2| 3| 3| 7| 7| 6| 7| 6| 6| 7| 6| 4| 7| 4| 4| 6| 2| 7| 4| 4| 7| 7| 6| 6|
DAY ON TEST | 3| 8| 2| 2| 3| 3| 5| 3| 6| 1| 3| 6| 5| 3| 7| 5| 8| 8| 3| 5| 3| 3| 3| 6| 6|
| 0| 8| 7| 7| 0| 0| 9| 0| 2| 4| 0| 2| 3| 0| 9| 3| 8| 8| 0| 3| 0| 0| 0| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
.038 G/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
KG 72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Pleura, Inflammation, Chronic | |
Pleura, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Nose | + + + + + + + M + M + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Mucosa, Inflammation, Chronic | |
Mucosa, Inflammation, Suppurative | 2 2 3 3 |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
Turbinate, Inflammation, Chronic | |
Turbinate, Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
__________________________________________________________________________|
Harderian Gland | +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
Inflammation, Acute | 3 |
Inflammation, Chronic | 2 4 2 1 1 3 3 2 2 2 2 2 1 2 2 |
Metaplasia | 2 |
Necrosis | 3 2 |
Cortex, Abscess, Single | |
Papilla, Mineralization | |
Renal Tubule, Dilatation | |
Renal Tubule, Hyperplasia | 4 |
Renal Tubule, Mineralization | |
Renal Tubule, Necrosis | |
Renal Tubule, Pigmentation | 1 2 2 1 1 1 2 1 1 1 2 2 2 2 2 2 1 3 1 2 1 2|
Renal Tubule, Regeneration | 1 3 1 1 2 3 1 1 1 1 1 1 3 1 2 1 2 1 1|
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + +|
Artery, Serosa, Inflammation, Chronic| |
Submucosa, Inflammation, Chronic | 1 3 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| | |
DAY ON TEST | 3| 3| 3| 3| 4| 5| 3| 3| 6| 3| | |
| 0| 0| 0| 0| 1| 3| 0| 0| 7| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
.038 G/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
KG 72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + A + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + M + + + M + | 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + M + + + + | 48 |
Lamina Propria, Congestion, Diffuse | | 1 4.0|
Lamina Propria, Pigmentation | 2 2 2 2 2 2 2 2 | 47 2.1|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 50 |
Lamina Propria, Congestion, Diffuse | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 50 |
Abscess, Single | | 1 3.0|
Angiectasis | | 1 3.0|
Clear Cell Focus | | 1 |
Fatty Change | | 1 4.0|
Hematopoietic Cell Proliferation | | 5 3.0|
Inflammation, Chronic | 2 2 | 8 1.9|
Necrosis | | 1 2.0|
Kupffer Cell, Pigmentation | 2 2 3 2 2 2 2 3 2 | 50 2.3|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Inflammation, Chronic | | 1 3.0|
Inflammation, Chronic Active | | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
Fat, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + M + + + + | 49 |
Inflammation, Chronic | 2 1 | 6 2.0|
Acinus, Atrophy | | 1 3.0|
Duct, Cyst | | 1 |
Interlobular, Inflammation, Acute | | 1 3.0|
Serosa, Interlobular, Inflammation, | | |
Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 49 |
Inflammation, Chronic | 2 2 2 2 | 18 1.8|
Artery, Inflammation, Chronic, | | |
Necrotizing | | 1 4.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| | |
DAY ON TEST | 3| 3| 3| 3| 4| 5| 3| 3| 6| 3| | |
| 0| 0| 0| 0| 1| 3| 0| 0| 7| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
.038 G/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
KG 72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 50 |
Acanthosis | 4 4 3 | 12 3.5|
Inflammation, Acute, Focal | | 2 3.0|
Inflammation, Chronic | 3 | 3 2.3|
Ulcer | 3 | 3 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 50 |
Artery, Inflammation, Chronic | 3 | 1 3.0|
Myocardium, Inflammation, Acute | | 1 4.0|
Pericardium, Inflammation, | | |
Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 50 |
Congestion | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + M + + + + + + | 44 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + + | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + + + M M + | 30 |
__________________________________________________________________________|____________|
Pituitary Gland | + I + M + + + + + | 44 |
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
Pars Distalis, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 50 |
Follicular Cell, Hyperplasia | 2 | 4 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + M + M + + + | 44 |
Cyst | X | 6 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | | 5 4.0|
Bilateral, Inflammation, Suppurative | | 2 4.0|
Follicle, Cyst | | 1 |
Periovarian Tissue, Inflammation, | | |
Chronic | | 3 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| | |
DAY ON TEST | 3| 3| 3| 3| 4| 5| 3| 3| 6| 3| | |
| 0| 0| 0| 0| 1| 3| 0| 0| 7| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
.038 G/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
KG 72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Periovarian Tissue, Inflammation, | | |
Suppurative | | 1 3.0|
Periovarian Tissue, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Oviduct | + | 9 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 49 |
Hydrometra | | 3 3.7|
Endometrium, Hyperplasia, Cystic | 4 4 2 3 3 4 | 23 3.1|
Endometrium, Inflammation, | | |
Suppurative | | 9 3.2|
Muscularis, Inflammation, Suppurative| 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 50 |
Myelofibrosis | 2 | 4 2.3|
Myeloid Cell, Hyperplasia | | 3 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 49 |
Lumbar, Hyperplasia, Plasma Cell | | 2 4.0|
Mandibular, Hyperplasia, Plasma Cell | | 2 3.5|
Mediastinal, Hyperplasia, Plasma Cell| | 1 4.0|
Pancreatic, Pigmentation | 4 | 5 2.8|
Renal, Hyperplasia, Lymphoid | | 1 4.0|
Renal, Hyperplasia, Plasma Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 46 |
Congestion | 2 | 2 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
Pigmentation | 3 3 | 8 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 50 |
Hematopoietic Cell Proliferation | 3 3 | 13 3.6|
Hyperplasia, Lymphoid | | 3 3.3|
Metaplasia | | 1 2.0|
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + M + + M + + + + | 39 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + M + M | 37 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| | |
DAY ON TEST | 3| 3| 3| 3| 4| 5| 3| 3| 6| 3| | |
| 0| 0| 0| 0| 1| 3| 0| 0| 7| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
.038 G/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
KG 72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 50 |
Joint, Tarsal, Hyperostosis | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 50 |
Cerebellum, Abscess, Multiple | | 1 4.0|
Meninges, Inflammation, Acute | | 1 4.0|
Meninges, Inflammation, Chronic | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Congestion | 3 | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Mediastinum, Inflammation, | | |
Suppurative | | 1 3.0|
Pleura, Inflammation, Chronic | 2 | 1 2.0|
Pleura, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 46 |
Inflammation, Suppurative | | 1 3.0|
Mucosa, Inflammation, Chronic | | 2 2.5|
Mucosa, Inflammation, Suppurative | 3 | 5 2.6|
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 1 1.0|
Turbinate, Inflammation, Chronic | | 1 2.0|
Turbinate, Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Amyloid Deposition | | 1 4.0|
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | 1 2 2 2 2 2 | 35 2.0|
Metaplasia | | 1 2.0|
Necrosis | 2 1 2 | 8 2.3|
Cortex, Abscess, Single | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| | |
DAY ON TEST | 3| 3| 3| 3| 4| 5| 3| 3| 6| 3| | |
| 0| 0| 0| 0| 1| 3| 0| 0| 7| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
.038 G/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
KG 72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Papilla, Mineralization | | 3 1.3|
Renal Tubule, Dilatation | | 1 2.0|
Renal Tubule, Hyperplasia | | 1 4.0|
Renal Tubule, Mineralization | | 1 2.0|
Renal Tubule, Necrosis | | 1 2.0|
Renal Tubule, Pigmentation | 1 1 1 2 2 1 2 2 2 | 50 1.6|
Renal Tubule, Regeneration | 1 2 2 2 1 1 | 42 1.6|
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 47 |
Artery, Serosa, Inflammation, Chronic| | 1 4.0|
Submucosa, Inflammation, Chronic | 2 2 | 15 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 6| 3| 5| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 6| 1| 7| 7| 7| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 0| 2| 3| 8| 3| 3| 3| 3| 4| 3| 3| 6| 6| 7| 4| 3| 3| 3| 6| 3| 1| 3| 3| 6|
| 6| 2| 8| 7| 3| 6| 6| 6| 6| 3| 6| 6| 1| 9| 0| 7| 6| 6| 9| 1| 6| 9| 6| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
72VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + M + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + A + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + A + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + A + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Fatty Change | 4 2 |
Inflammation, Chronic | 1 |
Necrosis | 2 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 |
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 2 2 1 2 2 2 2 2 2 2 1 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + |
Acanthosis | 2 |
Inflammation, Acute | 1 |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + |
Cyst | |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 6| 3| 5| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 6| 1| 7| 7| 7| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 0| 2| 3| 8| 3| 3| 3| 3| 4| 3| 3| 6| 6| 7| 4| 3| 3| 3| 6| 3| 1| 3| 3| 6|
| 6| 2| 8| 7| 3| 6| 6| 6| 6| 3| 6| 6| 1| 9| 0| 7| 6| 6| 9| 1| 6| 9| 6| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
72VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + M + M M M M + + + + + + + + M M M M M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + M + + + + + M + + + + M |
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + M + + + + |
Follicle, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Penis | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | |
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | |
Inflammation, Chronic | |
Inflammation, Suppurative | 4 2 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Suppurative | |
Interstitial Cell, Hyperplasia | |
Interstitial Tissue, Inflammation, | |
Suppurative | |
Seminiferous Tubule, Degeneration | |
Seminiferous Tubule, Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + M + + + + + M |
Lumbar, Hyperplasia, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + M |
Congestion | 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Hematopoietic Cell Proliferation | 4 3 4 |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Thymus | + + M M + M + + + M M + + + + M + M + M + + |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 6| 3| 5| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 6| 1| 7| 7| 7| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 0| 2| 3| 8| 3| 3| 3| 3| 4| 3| 3| 6| 6| 7| 4| 3| 3| 3| 6| 3| 1| 3| 3| 6|
| 6| 2| 8| 7| 3| 6| 6| 6| 6| 3| 6| 6| 1| 9| 0| 7| 6| 6| 9| 1| 6| 9| 6| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
72VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M + M M |
__________________________________________________________________________|
Skin | + + + + + + M + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
Dermis, Subcutaneous Tissue, Fibrosis| 4 |
Prepuce, Hyperkeratosis | 3 |
Prepuce, Inflammation, Suppurative | |
Prepuce, Necrosis, Focal | |
Subcutaneous Tissue, Inflammation, | |
Acute | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + |
Joint, Tarsal, Hyperostosis | X X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + |
Congestion | 2 |
Hemorrhage | 3 |
Alveolar Epithelium, Hyperplasia | 3 2 |
__________________________________________________________________________|
Nose | + + + M + + + + + + + + M + + + + + + + + M |
Mucosa, Inflammation, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 2 2 3 2 1 1 2 2 2 1 2 2 2 2 |
Metaplasia, Osseous | |
Nephropathy | |
Cortex, Inflammation, Suppurative | |
Papilla, Necrosis | 4 |
Renal Tubule, Dilatation | 1 |
Renal Tubule, Mineralization | 3 |
Renal Tubule, Regeneration | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 |
__________________________________________________________________________|
Urethra | + |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 6| 3| 5| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 6| 1| 7| 7| 7| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 0| 2| 3| 8| 3| 3| 3| 3| 4| 3| 3| 6| 6| 7| 4| 3| 3| 3| 6| 3| 1| 3| 3| 6|
| 6| 2| 8| 7| 3| 6| 6| 6| 6| 3| 6| 6| 1| 9| 0| 7| 6| 6| 9| 1| 6| 9| 6| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
72VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Mucosa, Lumen, Inflammation, | |
Suppurative | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + |
Mucosa, Inflammation, Acute | |
Mucosa, Necrosis | |
Serosa, Inflammation, Acute | 3 |
Submucosa, Hemorrhage | |
Submucosa, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 2| 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 6| 4| 5| 2| 1| 7| 7| 7| 7| 1|
DAY ON TEST | 3| 6| 3| 3| 1| 3| 3| 2| 8| 6| 3| 3| 3| 0| 6| 8| 6| 6| 0| 5| 3| 3| 3| 3| 1|
| 6| 1| 6| 6| 4| 6| 6| 1| 3| 9| 6| 9| 9| 7| 1| 5| 1| 3| 4| 7| 6| 6| 6| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
72VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + A + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + M + A + A + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + A + + + + M|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + M + + + + + + + A + M + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + A + + + + M|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + M|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + A + + + + M|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + A + + + + M|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Fatty Change | |
Inflammation, Chronic | |
Necrosis | 4 4 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 2 2 1 2 1 2 1 2 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 4 3 2 |
Inflammation, Acute | |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 2| 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 6| 4| 5| 2| 1| 7| 7| 7| 7| 1|
DAY ON TEST | 3| 6| 3| 3| 1| 3| 3| 2| 8| 6| 3| 3| 3| 0| 6| 8| 6| 6| 0| 5| 3| 3| 3| 3| 1|
| 6| 1| 6| 6| 4| 6| 6| 1| 3| 9| 6| 9| 9| 7| 1| 5| 1| 3| 4| 7| 6| 6| 6| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
72VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | M + M + M + + + M + + + M + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + M + M + + + + + + + + + + + + + M + + + +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Penis | + |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Preputial Gland | + + + +|
Duct, Ectasia | 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 4 |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 3 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + M + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
Interstitial Cell, Hyperplasia | 2 |
Interstitial Tissue, Inflammation, | |
Suppurative | 3 |
Seminiferous Tubule, Degeneration | 3 |
Seminiferous Tubule, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + M + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + M + + + + + + + M M + + + + +|
Lumbar, Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + M M + + + + +|
Congestion | 3 4 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + M M + + M M + M + + + + + + M M M + M + M|
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 2| 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 6| 4| 5| 2| 1| 7| 7| 7| 7| 1|
DAY ON TEST | 3| 6| 3| 3| 1| 3| 3| 2| 8| 6| 3| 3| 3| 0| 6| 8| 6| 6| 0| 5| 3| 3| 3| 3| 1|
| 6| 1| 6| 6| 4| 6| 6| 1| 3| 9| 6| 9| 9| 7| 1| 5| 1| 3| 4| 7| 6| 6| 6| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
72VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2|
Dermis, Subcutaneous Tissue, Fibrosis| |
Prepuce, Hyperkeratosis | |
Prepuce, Inflammation, Suppurative | 4 4 |
Prepuce, Necrosis, Focal | 4 |
Subcutaneous Tissue, Inflammation, | |
Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Hyperostosis | X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4|
Hemorrhage | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + M + + + + + + + M + + + + M M + + + + + +|
Mucosa, Inflammation, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 2 1 1 1 1 2 |
Metaplasia, Osseous | 2 |
Nephropathy | |
Cortex, Inflammation, Suppurative | 3 |
Papilla, Necrosis | |
Renal Tubule, Dilatation | |
Renal Tubule, Mineralization | 3|
Renal Tubule, Regeneration | 2 1 1 1 2 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Urethra | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 2| 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 6| 4| 5| 2| 1| 7| 7| 7| 7| 1|
DAY ON TEST | 3| 6| 3| 3| 1| 3| 3| 2| 8| 6| 3| 3| 3| 0| 6| 8| 6| 6| 0| 5| 3| 3| 3| 3| 1|
| 6| 1| 6| 6| 4| 6| 6| 1| 3| 9| 6| 9| 9| 7| 1| 5| 1| 3| 4| 7| 6| 6| 6| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
72VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Mucosa, Lumen, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + A M + + + +|
Mucosa, Inflammation, Acute | 3 |
Mucosa, Necrosis | 4 |
Serosa, Inflammation, Acute | |
Submucosa, Hemorrhage | 4|
Submucosa, Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 4| 4| 7| 7| 7| 6| | |
DAY ON TEST | 3| 6| 6| 3| 6| 6| 3| 3| 3| 3| | |
| 6| 1| 1| 9| 1| 1| 6| 6| 6| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
72VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + M | 46 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 50 |
Angiectasis | | 1 3.0|
Fatty Change | | 2 3.0|
Inflammation, Chronic | | 1 1.0|
Necrosis | | 4 2.8|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Necrosis, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 50 |
Inflammation, Chronic | 2 | 3 1.7|
Acinus, Atrophy | | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 50 |
Inflammation, Chronic | 1 | 26 1.5|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 50 |
Acanthosis | | 4 2.8|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 50 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
Peridontal Tissue, Inflammation, | | |
Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + M + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + M + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 4| 4| 7| 7| 7| 6| | |
DAY ON TEST | 3| 6| 6| 3| 6| 6| 3| 3| 3| 3| | |
| 6| 1| 1| 9| 1| 1| 6| 6| 6| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
72VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Cyst | | 1 |
Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + M + + + + | 49 |
Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + | 33 |
__________________________________________________________________________|____________|
Pituitary Gland | + I + + M + | 41 |
Pars Distalis, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 49 |
Follicle, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 50 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Penis | | 1 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | | 4 |
Duct, Ectasia | | 2 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + | 50 |
Inflammation, Acute | | 1 4.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | | 5 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 49 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + | 50 |
Inflammation, Suppurative | | 1 4.0|
Interstitial Cell, Hyperplasia | | 1 2.0|
Interstitial Tissue, Inflammation, | | |
Suppurative | | 1 3.0|
Seminiferous Tubule, Degeneration | 2 | 2 2.5|
Seminiferous Tubule, Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 49 |
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + M | 44 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 4| 4| 7| 7| 7| 6| | |
DAY ON TEST | 3| 6| 6| 3| 6| 6| 3| 3| 3| 3| | |
| 6| 1| 1| 9| 1| 1| 6| 6| 6| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
72VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Hyperplasia, Plasma Cell | | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + M | 44 |
Congestion | 4 | 6 3.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 50 |
Angiectasis | | 1 3.0|
Hematopoietic Cell Proliferation | | 3 3.7|
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | M + M + + M | 29 |
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 49 |
Inflammation, Chronic | | 1 2.0|
Dermis, Subcutaneous Tissue, Fibrosis| | 1 4.0|
Prepuce, Hyperkeratosis | | 1 3.0|
Prepuce, Inflammation, Suppurative | | 2 4.0|
Prepuce, Necrosis, Focal | | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 50 |
Joint, Tarsal, Hyperostosis | | 7 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + | 50 |
Congestion | | 2 3.0|
Hemorrhage | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Nose | + M + + + + | 42 |
Mucosa, Inflammation, Suppurative | 3 | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 4| 4| 7| 7| 7| 6| | |
DAY ON TEST | 3| 6| 6| 3| 6| 6| 3| 3| 3| 3| | |
| 6| 1| 1| 9| 1| 1| 6| 6| 6| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
72VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 50 |
Inflammation, Chronic | 1 1 2 | 26 1.6|
Metaplasia, Osseous | | 1 2.0|
Nephropathy | 3 | 1 3.0|
Cortex, Inflammation, Suppurative | | 1 3.0|
Papilla, Necrosis | | 1 4.0|
Renal Tubule, Dilatation | | 1 1.0|
Renal Tubule, Mineralization | | 2 3.0|
Renal Tubule, Regeneration | 1 1 1 1 1 2 | 34 1.1|
__________________________________________________________________________|____________|
Urethra | | 1 |
Mucosa, Lumen, Inflammation, | | |
Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 47 |
Mucosa, Inflammation, Acute | | 1 3.0|
Mucosa, Necrosis | | 1 4.0|
Serosa, Inflammation, Acute | | 1 3.0|
Submucosa, Hemorrhage | | 1 4.0|
Submucosa, Inflammation, Chronic | 2 | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 5| 5| 1| 7| 7| 7| 6| 4| 4| 7| 7| 7| 0| 4| 7| 7| 5| 2|
DAY ON TEST | 3| 3| 3| 3| 1| 1| 0| 7| 1| 0| 3| 3| 3| 2| 6| 6| 3| 3| 3| 9| 6| 3| 3| 9| 3|
| 5| 5| 5| 5| 9| 7| 2| 1| 8| 2| 5| 5| 5| 4| 1| 1| 5| 5| 5| 8| 1| 5| 5| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.019 G/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + M + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
Lamina Propria, Pigmentation | 1 2 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 2 1 1|
__________________________________________________________________________|
Intestine Small, Ileum | + + M A + + + + + +|
Peyer's Patch, Hyperplasia, | |
Neutrophil | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Cyst | |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | 2 2 |
Kupffer Cell, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Mesentery | + + |
Necrosis, Multifocal | 4 |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + +|
Inflammation, Chronic | 1 2 1 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + +|
Acanthosis | 2 4 4 2 |
Cyst | |
Inflammation, Chronic | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M M + M + M|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 5| 5| 1| 7| 7| 7| 6| 4| 4| 7| 7| 7| 0| 4| 7| 7| 5| 2|
DAY ON TEST | 3| 3| 3| 3| 1| 1| 0| 7| 1| 0| 3| 3| 3| 2| 6| 6| 3| 3| 3| 9| 6| 3| 3| 9| 3|
| 5| 5| 5| 5| 9| 7| 2| 1| 8| 2| 5| 5| 5| 4| 1| 1| 5| 5| 5| 8| 1| 5| 5| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.019 G/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + M + + + + + +|
Inflammation, Focal, Granulomatous | 3 |
__________________________________________________________________________|
Penis | + + |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 4 |
Necrosis | 4 |
__________________________________________________________________________|
Preputial Gland | + + + +|
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 4 4|
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + +|
Inflammation, Acute | 2|
Inflammation, Suppurative | 3 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + +|
Seminiferous Tubule, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + +|
Myeloid Cell, Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + M + + + + + + + + + + +|
Lumbar, Hyperplasia, Plasma Cell | 3 |
Mediastinal, Hyperplasia, Lymphoid | 4 |
Pancreatic, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + +|
Congestion | 2 2 3 2 3 4 4 |
Hematopoietic Cell Proliferation | 4 |
Pigmentation | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 3 4 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + + M + + M + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 5| 5| 1| 7| 7| 7| 6| 4| 4| 7| 7| 7| 0| 4| 7| 7| 5| 2|
DAY ON TEST | 3| 3| 3| 3| 1| 1| 0| 7| 1| 0| 3| 3| 3| 2| 6| 6| 3| 3| 3| 9| 6| 3| 3| 9| 3|
| 5| 5| 5| 5| 9| 7| 2| 1| 8| 2| 5| 5| 5| 4| 1| 1| 5| 5| 5| 8| 1| 5| 5| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.019 G/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Parakeratosis, Multifocal | 2 |
Ulcer, Multiple | |
Dermis, Fibrosis | 4 |
Dermis, Inflammation, Chronic | |
Prepuce, Inflammation, Suppurative | 4 4 |
Subcutaneous Tissue, Inflammation, | |
Granulomatous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + +|
Hyperostosis | X |
Joint, Tarsal, Hyperostosis | X X X X X X |
__________________________________________________________________________|
Skeletal Muscle | +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + +|
Congestion | 3 |
Perivascular, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + M + + + M M|
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 1 1 1 1 1 2 |
Necrosis | 2 1 1 1 1 |
Pelvis, Inflammation, Acute | 2 |
Renal Tubule, Calculus Micro | |
Observation Only | 2 |
Renal Tubule, Dilatation | 1 1 1 |
Renal Tubule, Pigmentation | 1 1 1 1 |
Renal Tubule, Regeneration | 1 1 1 1 2 1 1 1 2 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + +|
Mucosa, Inflammation, Subacute | 4 |
Mucosa, Necrosis | 4 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 4| 4| 4| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 6| 6| 6| 7| 2| 3| 3| 1| 8| 3| 3| 3| 3| 0| 3| 3| 6| 3| 3|
| 5| 5| 4| 4| 4| 7| 1| 1| 1| 0| 1| 5| 5| 3| 3| 5| 5| 5| 5| 7| 6| 5| 1| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.019 G/ | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + |
__________________________________________________________________________|
Gallbladder | + + M + + |
__________________________________________________________________________|
Intestine Large | + + + + M |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + M |
__________________________________________________________________________|
Intestine Large, Colon | + + + + M |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + M + + + +|
Lamina Propria, Pigmentation | 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 2 1 1|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + M |
Peyer's Patch, Hyperplasia, | |
Neutrophil | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + M |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | |
Kupffer Cell, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Mesentery | + |
Necrosis, Multifocal | |
Fat, Necrosis, Focal | 4 |
__________________________________________________________________________|
Pancreas | + + + + + |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + |
Inflammation, Chronic | 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + |
Acanthosis | 3 3 2 4 |
Cyst | X |
Inflammation, Chronic | 1 |
Ulcer | 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M + M + M |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 4| 4| 4| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 6| 6| 6| 7| 2| 3| 3| 1| 8| 3| 3| 3| 3| 0| 3| 3| 6| 3| 3|
| 5| 5| 4| 4| 4| 7| 1| 1| 1| 0| 1| 5| 5| 3| 3| 5| 5| 5| 5| 7| 6| 5| 1| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.019 G/ | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + |
Inflammation, Focal, Granulomatous | |
__________________________________________________________________________|
Penis | + |
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | |
Necrosis | |
__________________________________________________________________________|
Preputial Gland | + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | 3 |
Duct, Ectasia | 4 4|
__________________________________________________________________________|
Prostate | + + + + + |
Inflammation, Acute | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + |
Seminiferous Tubule, Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + |
Lumbar, Hyperplasia, Plasma Cell | |
Mediastinal, Hyperplasia, Lymphoid | |
Pancreatic, Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + |
Congestion | 4 3 2 3 3 3 4 2 4 3 2 |
Hematopoietic Cell Proliferation | |
Pigmentation | 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 4| 4| 4| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 6| 6| 6| 7| 2| 3| 3| 1| 8| 3| 3| 3| 3| 0| 3| 3| 6| 3| 3|
| 5| 5| 4| 4| 4| 7| 1| 1| 1| 0| 1| 5| 5| 3| 3| 5| 5| 5| 5| 7| 6| 5| 1| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.019 G/ | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Parakeratosis, Multifocal | |
Ulcer, Multiple | 3 |
Dermis, Fibrosis | |
Dermis, Inflammation, Chronic | 2 |
Prepuce, Inflammation, Suppurative | |
Subcutaneous Tissue, Inflammation, | |
Granulomatous | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
Hyperostosis | |
Joint, Tarsal, Hyperostosis | X X X X X X |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + |
Congestion | |
Perivascular, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Nose | + M + + + |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Trachea | + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 4 2 2 2 1 1|
Necrosis | 3 3 1 1 1|
Pelvis, Inflammation, Acute | |
Renal Tubule, Calculus Micro | |
Observation Only | |
Renal Tubule, Dilatation | 1 1 1 1 1 1 1 1 1 |
Renal Tubule, Pigmentation | 1 1 1 1 |
Renal Tubule, Regeneration | 2 3 1 1 1 1 1 2 3 2 1 1 2 1 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + |
Mucosa, Inflammation, Subacute | |
Mucosa, Necrosis | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 7| 7| 7| 4| | |
DAY ON TEST | 4| 6| 3| 6| 3| 3| 3| 3| 3| 6| | |
| 9| 1| 5| 1| 5| 5| 5| 5| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.019 G/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 14 |
__________________________________________________________________________|____________|
Gallbladder | + | 14 |
__________________________________________________________________________|____________|
Intestine Large | + | 14 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 14 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 12 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + | 49 |
Lamina Propria, Pigmentation | 2 1 1 1 1 1 1 | 48 1.2|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 13 |
Peyer's Patch, Hyperplasia, | | |
Neutrophil | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 14 |
__________________________________________________________________________|____________|
Liver | + + + + + + + | 50 |
Angiectasis | | 1 4.0|
Cyst | | 1 |
Hematopoietic Cell Proliferation | 4 | 1 4.0|
Inflammation, Chronic | | 2 2.0|
Kupffer Cell, Pigmentation | 1 1 1 1 1 1 1 | 44 1.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Necrosis, Multifocal | | 1 4.0|
Fat, Necrosis, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + | 16 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + | 15 |
Inflammation, Chronic | | 7 1.9|
__________________________________________________________________________|____________|
Stomach | + + | 23 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 23 |
Acanthosis | 3 4 | 10 3.1|
Cyst | | 1 |
Inflammation, Chronic | 3 2 | 3 2.0|
Ulcer | | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 22 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 7| 7| 7| 4| | |
DAY ON TEST | 4| 6| 3| 6| 3| 3| 3| 3| 3| 6| | |
| 9| 1| 5| 1| 5| 5| 5| 5| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.019 G/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + | 15 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + | 15 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 15 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 8 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 15 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + | 15 |
Inflammation, Focal, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Penis | | 3 |
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Suppurative | | 1 4.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | M + | 8 |
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | | 3 3.7|
Duct, Ectasia | 3 | 3 3.7|
__________________________________________________________________________|____________|
Prostate | + | 15 |
Inflammation, Acute | | 1 2.0|
Inflammation, Suppurative | | 2 3.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 19 |
__________________________________________________________________________|____________|
Testes | + | 16 |
Seminiferous Tubule, Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 15 |
Myeloid Cell, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 36 |
Lumbar, Hyperplasia, Plasma Cell | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 4.0|
Pancreatic, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 32 |
Congestion | | 18 2.9|
Hematopoietic Cell Proliferation | 3 | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 7| 7| 7| 4| | |
DAY ON TEST | 4| 6| 3| 6| 3| 3| 3| 3| 3| 6| | |
| 9| 1| 5| 1| 5| 5| 5| 5| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.019 G/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pigmentation | 1 | 5 1.0|
__________________________________________________________________________|____________|
Spleen | + + | 19 |
Hematopoietic Cell Proliferation | 3 | 4 3.5|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M | 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M | |
__________________________________________________________________________|____________|
Skin | + + + | 29 |
Inflammation, Chronic | | 1 2.0|
Parakeratosis, Multifocal | | 1 2.0|
Ulcer, Multiple | | 1 3.0|
Dermis, Fibrosis | | 1 4.0|
Dermis, Inflammation, Chronic | | 1 2.0|
Prepuce, Inflammation, Suppurative | | 2 4.0|
Subcutaneous Tissue, Inflammation, | | |
Granulomatous | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 19 |
Hyperostosis | | 1 |
Joint, Tarsal, Hyperostosis | X X | 14 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 15 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 19 |
Congestion | | 1 3.0|
Perivascular, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + | 11 |
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 7| 7| 7| 4| | |
DAY ON TEST | 4| 6| 3| 6| 3| 3| 3| 3| 3| 6| | |
| 9| 1| 5| 1| 5| 5| 5| 5| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.019 G/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + | 48 |
Inflammation, Chronic | 1 | 16 1.8|
Necrosis | 1 1 | 12 1.4|
Pelvis, Inflammation, Acute | | 1 2.0|
Renal Tubule, Calculus Micro | | |
Observation Only | | 1 2.0|
Renal Tubule, Dilatation | 1 1 2 | 15 1.1|
Renal Tubule, Pigmentation | | 8 1.0|
Renal Tubule, Regeneration | 2 1 1 1 1 | 34 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + | 15 |
Mucosa, Inflammation, Subacute | | 1 4.0|
Mucosa, Necrosis | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 4| 5| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 2| 2| 2| 6| 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| 3| 3| 6| 7| 6| 3| 3| 3| 3| 3|
| 9| 9| 9| 9| 1| 3| 3| 3| 3| 8| 3| 3| 3| 1| 3| 3| 3| 1| 9| 1| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.038 G/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
KG 72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + M + M + M + + + + +|
__________________________________________________________________________|
Gallbladder | + + M + + + + + + + + + + + M + + + + + +|
Serosa, Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + M + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + M + + + +|
Lamina Propria, Pigmentation | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 3 3 1 2 2 1|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Fatty Change | 3 |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | 2 2 |
Mixed Cell Focus | |
Necrosis | 3 4 |
Kupffer Cell, Pigmentation | 1 2 1 1 1 2 2 2 2 2 2 2 1 1 2 2 2 2 2 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Acinus, Atrophy | |
Acinus, Hypertrophy, Focal | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 3 3 1 2 1 1 2 2 2 2 2 2 |
Acinus, Atrophy, Focal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 4 4 4 3 3 4 3 3 |
Inflammation, Acute | 3 1 2 1 |
Inflammation, Chronic | 2 |
Inflammation, Focal | 3 |
Mineralization | |
Ulcer | 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Chronic | |
Pulp, Inflammation, Necrotizing | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 4| 5| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 2| 2| 2| 6| 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| 3| 3| 6| 7| 6| 3| 3| 3| 3| 3|
| 9| 9| 9| 9| 1| 3| 3| 3| 3| 8| 3| 3| 3| 1| 3| 3| 3| 1| 9| 1| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.038 G/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
KG 72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Coronary Artery, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + M + M M + M M + + M|
Cyst, Multiple | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Intermedia, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + +|
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 4|
Duct, Ectasia | 4 |
__________________________________________________________________________|
Prostate | + M + M + + + + + M + + + + + + + + + M +|
Inflammation, Acute | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + M + + + + + + + + + + + + +|
Pancreatic, Pigmentation | 2 1 2|
Renal, Hyperplasia, Histiocytic | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + +|
Congestion | 2 3 4 3 2 3|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 4| 5| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 2| 2| 2| 6| 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| 3| 3| 6| 7| 6| 3| 3| 3| 3| 3|
| 9| 9| 9| 9| 1| 3| 3| 3| 3| 8| 3| 3| 3| 1| 3| 3| 3| 1| 9| 1| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.038 G/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
KG 72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation | 2 2 2 1 1 1 1 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 |
Hyperplasia, Lymphoid | 3 |
Pigmentation | 1 |
__________________________________________________________________________|
Thymus | M + M + + + + + M + M + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Ulcer, Multiple | |
Dermis, Fibrosis | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
Joint, Tarsal, Hyperostosis | X X X X |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Peribronchiolar, Perivascular, | |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Nose | + + + M + + + + M + + + + M + M M + + + +|
Nasolacrimal Duct, Hyperplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 3 2 2 2 2 2 2 3 3 2 2 2 2 2 2|
Metaplasia | |
Metaplasia, Osseous | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 4| 5| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 2| 2| 2| 6| 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| 3| 3| 6| 7| 6| 3| 3| 3| 3| 3|
| 9| 9| 9| 9| 1| 3| 3| 3| 3| 8| 3| 3| 3| 1| 3| 3| 3| 1| 9| 1| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.038 G/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
KG 72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Necrosis | 1 2 2 2 2 2 2 1 2 2 2 2 2 1 1 1|
Papilla, Necrosis | |
Renal Tubule, Dilatation | 2 2 2 3 1 2 1 1 3 2 2 3 3 3 2 3 2 2 2 1 2|
Renal Tubule, Hyperplasia | 2 1 2 |
Renal Tubule, Mineralization | 2 2 1|
Renal Tubule, Pigmentation | 1 2 2 2 1 1 1 1 2 1 2 2 2 2 3 2 1 2 1 2|
Renal Tubule, Regeneration | 2 2 3 3 2 2 2 3 2 2 3 3 3 2 3 2 2 2 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Concretion | 3 |
Serosa, Inflammation | |
Submucosa, Inflammation, Chronic | 2 1 |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 1| 7| 4| 7| 6| 3| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 3| 3| 0| 3| 3| 3| 6| 6| 3| 3| 3| 2| 3| 3| 6| 3| 0| 7| 3| 3| 3| 3| 3|
| 3| 1| 3| 3| 6| 3| 3| 3| 8| 1| 3| 3| 3| 1| 6| 3| 1| 3| 3| 8| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.038 G/ | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
KG 72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + M M + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + M + + M M + + + + + + + + +|
Serosa, Inflammation, Acute | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
Lamina Propria, Pigmentation | 1 2 2 1 2 1 1 2 2 2 1 2 1 1 2 2 1 2 2 3 3|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Fatty Change | |
Hematopoietic Cell Proliferation | 3 |
Inflammation, Chronic | 2 |
Mixed Cell Focus | |
Necrosis | |
Kupffer Cell, Pigmentation | 2 1 2 1 2 2 1 2 2 2 3 1 2 2 2 3 2 2 2 2 4|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 3 2 |
Acinus, Hypertrophy, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 1 2 1 1 1 2 1 2 1 2|
Acinus, Atrophy, Focal | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 3 4 4|
Inflammation, Acute | |
Inflammation, Chronic | |
Inflammation, Focal | |
Mineralization | |
Ulcer | 2 3 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Chronic | 3 |
Pulp, Inflammation, Necrotizing | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 1| 7| 4| 7| 6| 3| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 3| 3| 0| 3| 3| 3| 6| 6| 3| 3| 3| 2| 3| 3| 6| 3| 0| 7| 3| 3| 3| 3| 3|
| 3| 1| 3| 3| 6| 3| 3| 3| 8| 1| 3| 3| 3| 1| 6| 3| 1| 3| 3| 8| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.038 G/ | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
KG 72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Artery, Inflammation, Chronic | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Coronary Artery, Inflammation, | |
Chronic | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | M + + M + + M + M + M + + + + M M + + M M M|
Cyst, Multiple | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Pars Intermedia, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + |
Inflammation, Chronic | |
Inflammation, Suppurative | 4 |
Duct, Ectasia | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Pancreatic, Pigmentation | 3 4 |
Renal, Hyperplasia, Histiocytic | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 3 2 2 4 3 |
Hyperplasia, Lymphoid | 4 |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 1| 7| 4| 7| 6| 3| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 3| 3| 0| 3| 3| 3| 6| 6| 3| 3| 3| 2| 3| 3| 6| 3| 0| 7| 3| 3| 3| 3| 3|
| 3| 1| 3| 3| 6| 3| 3| 3| 8| 1| 3| 3| 3| 1| 6| 3| 1| 3| 3| 8| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.038 G/ | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
KG 72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation | 1 1 1 2 1 3|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 |
Hyperplasia, Lymphoid | |
Pigmentation | |
__________________________________________________________________________|
Thymus | M + + + M + M + M + M + A M M + M + + M M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M + M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Ulcer, Multiple | |
Dermis, Fibrosis | 4 |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | X |
Joint, Tarsal, Hyperostosis | X X X X X X X |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Peribronchiolar, Perivascular, | |
Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + M + + M + M + + I + + + + + + + + +|
Nasolacrimal Duct, Hyperplasia, | |
Squamous | 3 |
__________________________________________________________________________|
Trachea | + + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 2 1 2 2 2 2 2 1 2 2 2|
Metaplasia | |
Metaplasia, Osseous | 3 |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 1| 7| 4| 7| 6| 3| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 3| 3| 0| 3| 3| 3| 6| 6| 3| 3| 3| 2| 3| 3| 6| 3| 0| 7| 3| 3| 3| 3| 3|
| 3| 1| 3| 3| 6| 3| 3| 3| 8| 1| 3| 3| 3| 1| 6| 3| 1| 3| 3| 8| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.038 G/ | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
KG 72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Necrosis | 1 1 1 2 1 2 2 1 1 2 1 |
Papilla, Necrosis | |
Renal Tubule, Dilatation | 2 2 1 1 3 2 2 2 3 2 2 1 2 2 1 2 2 3 2|
Renal Tubule, Hyperplasia | |
Renal Tubule, Mineralization | 1 4 2 2|
Renal Tubule, Pigmentation | 2 1 1 1 1 1 2 1 3 2 2 1 1 1 1 1 1 1 1 1 4|
Renal Tubule, Regeneration | 2 2 2 2 1 2 2 1 3 2 1 1 3 2 1 1 1 1 1 3 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Concretion | |
Serosa, Inflammation | 2 |
Submucosa, Inflammation, Chronic | 2 2 |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 4| 6| 4| 6| 4| | |
DAY ON TEST | 3| 3| 1| 7| 6| 6| 9| 6| 5| 5| | |
| 3| 3| 3| 0| 1| 1| 4| 1| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
.038 G/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
KG 72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 44 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A + | 44 |
Serosa, Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + | 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + | 48 |
Lamina Propria, Pigmentation | 2 2 4 1 1 2 | 47 1.8|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + | 48 |
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + | 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + | 50 |
Fatty Change | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Inflammation, Chronic | | 3 2.0|
Mixed Cell Focus | X | 1 |
Necrosis | 1 | 3 2.7|
Kupffer Cell, Pigmentation | 2 2 2 4 2 3 | 47 1.9|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 50 |
Inflammation, Chronic | 1 | 2 1.0|
Acinus, Atrophy | | 2 2.5|
Acinus, Hypertrophy, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 50 |
Inflammation, Chronic | 2 2 1 2 1 | 31 1.7|
Acinus, Atrophy, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 50 |
Acanthosis | 3 | 13 3.5|
Inflammation, Acute | 2 | 5 1.8|
Inflammation, Chronic | | 1 2.0|
Inflammation, Focal | | 1 3.0|
Mineralization | 2 | 1 2.0|
Ulcer | | 5 2.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 50 |
Pigmentation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
Peridontal Tissue, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 4| 6| 4| 6| 4| | |
DAY ON TEST | 3| 3| 1| 7| 6| 6| 9| 6| 5| 5| | |
| 3| 3| 3| 0| 1| 1| 4| 1| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
.038 G/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
KG 72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Chronic | | 1 3.0|
Pulp, Inflammation, Necrotizing | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Artery, Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + | 50 |
Coronary Artery, Inflammation, | | |
Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 50 |
Hyperplasia | 3 | 3 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + | 33 |
Cyst, Multiple | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 50 |
Pars Intermedia, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 49 |
Follicular Cell, Hyperplasia | | 3 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + | 50 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + | 6 |
Inflammation, Chronic | 4 | 2 3.0|
Inflammation, Suppurative | | 2 4.0|
Duct, Ectasia | | 2 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + | 46 |
Inflammation, Acute | | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 4| 6| 4| 6| 4| | |
DAY ON TEST | 3| 3| 1| 7| 6| 6| 9| 6| 5| 5| | |
| 3| 3| 3| 0| 1| 1| 4| 1| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
.038 G/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
KG 72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood | + | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 50 |
Myelofibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 49 |
Pancreatic, Pigmentation | 4 3 | 7 2.7|
Renal, Hyperplasia, Histiocytic | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + | 49 |
Congestion | 4 4 4 | 16 3.0|
Hyperplasia, Lymphoid | | 1 4.0|
Pigmentation | 1 2 1 | 17 1.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + + | 50 |
Hematopoietic Cell Proliferation | 4 | 5 4.0|
Hyperplasia, Lymphoid | | 1 3.0|
Pigmentation | 4 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | M + + + M M + | 31 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + | 50 |
Ulcer, Multiple | 4 | 1 4.0|
Dermis, Fibrosis | | 2 3.5|
Subcutaneous Tissue, Inflammation, | | |
Chronic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 50 |
Hyperostosis | | 1 |
Joint, Tarsal, Hyperostosis | X | 12 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 50 |
Congestion | | 1 2.0|
Peribronchiolar, Perivascular, | | |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05043-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:53:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 4| 6| 4| 6| 4| | |
DAY ON TEST | 3| 3| 1| 7| 6| 6| 9| 6| 5| 5| | |
| 3| 3| 3| 0| 1| 1| 4| 1| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
.038 G/ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
KG 72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | M + M + + + + | 39 |
Nasolacrimal Duct, Hyperplasia, | | |
Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + | 50 |
Inflammation, Chronic | 2 1 2 2 1 2 | 38 2.0|
Metaplasia | 2 | 1 2.0|
Metaplasia, Osseous | | 1 3.0|
Necrosis | 2 2 2 | 30 1.6|
Papilla, Necrosis | 2 | 1 2.0|
Renal Tubule, Dilatation | 1 4 2 1 2 1 | 46 2.0|
Renal Tubule, Hyperplasia | | 3 1.7|
Renal Tubule, Mineralization | 3 | 8 2.1|
Renal Tubule, Pigmentation | 2 1 3 1 1 1 | 47 1.5|
Renal Tubule, Regeneration | 2 1 1 2 2 2 2 | 48 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 50 |
Concretion | | 1 3.0|
Serosa, Inflammation | | 1 2.0|
Submucosa, Inflammation, Chronic | 1 1 | 6 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
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