TDMS Study 05043-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
2,4-DIAMINOPHENOL DIHYDROCHLORIDE
NTP Experiment-Test: 05043-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/05/94
Route: GAVAGE Time: 17:45:26
Facility: TSI Mason Research
Chemical CAS #: 137-09-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05043-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 17:45:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .0125 G/ .025G/KG
72VF KG 72LF 72HF
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 13 12 16
Dead 7 6 2
Accident 1
Survivors
Terminal Sacrifice 30 32 31
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (8) (11) (8)
Mucosa, Pigmentation 1 (9%)
Intestine Large, Colon (9) (14) (9)
Parasite Metazoan 1 (11%)
Intestine Large, Rectum (8) (11) (7)
Parasite Metazoan 1 (9%)
Intestine Small, Duodenum (49) (50) (50)
Lamina Propria, Inflammation, Acute 1 (2%)
Lamina Propria, Pigmentation 50 (100%) 50 (100%)
Liver (50) (30) (50)
Angiectasis, Focal 1 (2%)
Basophilic Focus 36 (72%) 19 (63%) 40 (80%)
Clear Cell Focus 3 (6%) 5 (10%)
Congestion 2 (7%)
Eosinophilic Focus 1 (2%)
Fatty Change 14 (28%) 12 (40%) 9 (18%)
Granuloma 1 (2%)
Hematocyst 1 (2%)
Hematopoietic Cell Proliferation 1 (3%)
Hemorrhage, Multifocal 1 (3%)
Hepatodiaphragmatic Nodule 5 (10%) 3 (10%) 5 (10%)
Inflammation, Chronic 3 (6%)
Inflammation, Granulomatous 4 (8%) 2 (7%) 10 (20%)
Mixed Cell Focus 1 (2%) 1 (3%) 1 (2%)
Necrosis, Focal 1 (2%)
Necrosis, Multifocal 1 (3%)
Bile Duct, Hyperplasia 25 (50%) 10 (33%) 27 (54%)
Centrilobular, Inflammation, Acute 1 (2%)
Centrilobular, Necrosis 1 (2%)
Midzonal, Necrosis 1 (2%)
Sinusoid, Embolus Bacterial 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05043-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 17:45:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .0125 G/ .025G/KG
72VF KG 72LF 72HF
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mesentery (6) (5) (4)
Inflammation, Chronic 1 (17%) 1 (25%)
Fat, Necrosis, Focal 3 (50%) 5 (100%) 2 (50%)
Pancreas (49) (13) (50)
Inflammation, Chronic, Diffuse 1 (2%)
Acinus, Atrophy 5 (10%) 4 (8%)
Acinus, Hyperplasia, Focal 1 (2%) 5 (10%)
Acinus, Hypertrophy, Focal 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Duct, Cyst 1 (2%)
Duct, Hyperplasia 1 (2%)
Serosa, Neovascularization, Diffuse 1 (2%)
Salivary Glands (21) (12) (28)
Embolus Bacterial 1 (5%)
Stomach, Forestomach (50) (14) (50)
Acanthosis 7 (14%)
Pigmentation 1 (7%) 9 (18%)
Ulcer 2 (4%) 3 (21%) 3 (6%)
Stomach, Glandular (48) (13) (49)
Edema 1 (2%)
Embolus Bacterial 1 (2%)
Erosion, Focal 1 (2%)
Hyperplasia, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (13) (49)
Cardiomyopathy 16 (32%) 2 (15%) 17 (35%)
Inflammation, Chronic 1 (2%)
Interstitium, Embolus Bacterial 1 (2%)
Ventricle, Fibrosis 1 (8%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (15) (50)
Capsule, Degeneration 1 (7%)
Adrenal Gland, Cortex (50) (15) (50)
Congestion 1 (7%) 1 (2%)
Degeneration 12 (24%) 2 (13%) 5 (10%)
Degeneration, Focal 1 (2%)
Embolus Bacterial 1 (2%)
Hyperplasia 2 (4%) 1 (7%) 2 (4%)
Hyperplasia, Focal 3 (6%) 1 (2%)
Hypertrophy 1 (2%)
Necrosis 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05043-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 17:45:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .0125 G/ .025G/KG
72VF KG 72LF 72HF
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Vacuolization Cytoplasmic 1 (2%)
Adrenal Gland, Medulla (47) (15) (48)
Congestion 1 (7%)
Hyperplasia 4 (9%) 1 (2%)
Hyperplasia, Focal 3 (6%) 1 (7%)
Islets, Pancreatic (49) (14) (50)
Hyperplasia 2 (4%)
Pituitary Gland (50) (50) (50)
Cyst 3 (6%) 1 (2%)
Pars Distalis, Angiectasis 2 (4%) 3 (6%) 2 (4%)
Pars Distalis, Cyst 3 (6%) 1 (2%) 2 (4%)
Pars Distalis, Embolus Bacterial 1 (2%)
Pars Distalis, Hemorrhage 2 (4%)
Pars Distalis, Hyperplasia, Focal 3 (6%) 7 (14%) 5 (10%)
Thyroid Gland (50) (12) (50)
Embolus Bacterial 1 (2%)
C-Cell, Hyperplasia 10 (20%) 2 (4%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Necrosis 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (12) (17) (9)
Inflammation, Chronic 1 (6%)
Inflammation, Suppurative 1 (8%) 1 (6%) 1 (11%)
Duct, Cyst 1 (8%)
Ovary (49) (15) (49)
Cyst 1 (2%)
Follicle, Cyst 1 (2%) 1 (7%)
Uterus (50) (15) (50)
Endometriosis 1 (2%)
Hydrometra 1 (7%) 1 (2%)
Cervix, Hyperplasia, Cystic 1 (2%)
Endometrium, Hyperplasia, Cystic 2 (4%) 5 (10%)
Lumen, Hemorrhage 1 (2%)
Wall, Necrosis 1 (2%)
Vagina (1)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05043-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 17:45:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .0125 G/ .025G/KG
72VF KG 72LF 72HF
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (49) (49) (50)
Lumbar, Cyst 1 (2%)
Mediastinal, Congestion 1 (2%) 1 (2%)
Mediastinal, Pigmentation, Hemosiderin 3 (6%) 2 (4%)
Pancreatic, Pigmentation 2 (4%) 35 (71%) 33 (66%)
Renal, Congestion 1 (2%)
Lymph Node, Mandibular (44) (10) (46)
Congestion 1 (2%)
Hyperplasia, Plasma Cell 1 (2%)
Pigmentation 1 (2%)
Lymph Node, Mesenteric (49) (49) (50)
Congestion 1 (2%) 1 (2%)
Pigmentation 32 (65%) 26 (53%) 45 (90%)
Pigmentation, Hemosiderin 2 (4%)
Spleen (50) (20) (50)
Embolus Bacterial 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 4 (20%) 2 (4%)
Necrosis 1 (2%)
Pigmentation, Hemosiderin 2 (4%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (27) (29) (19)
Hyperplasia 3 (11%) 1 (3%)
Hyperplasia, Cystic 4 (15%) 5 (17%) 1 (5%)
Skin (12) (13) (9)
Face, Abscess 1 (11%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (11) (50)
Embolus Bacterial 1 (2%)
Cerebrum, Perivascular, Inflammation 1 (2%)
Spinal Cord (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05043-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 17:45:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .0125 G/ .025G/KG
72VF KG 72LF 72HF
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (17) (50)
Adenomatosis 2 (4%) 1 (2%)
Congestion 5 (10%) 7 (41%) 2 (4%)
Hemorrhage, Focal 1 (6%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Inflammation, Granulomatous 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%) 1 (6%)
Capillary, Embolus Bacterial 1 (2%)
Interstitium, Inflammation, Chronic 1 (2%)
Nose (9) (12) (6)
Nasolacrimal Duct, Inflammation, Chronic 1 (11%) 1 (17%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (7) (3)
Lens, Mineralization 2 (67%)
Harderian Gland (1) (1) (1)
Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Congestion 1 (2%)
Nephropathy 31 (62%) 39 (78%) 42 (84%)
Capillary, Embolus Bacterial 1 (2%)
Cortex, Cyst 2 (4%)
Papilla, Necrosis, Diffuse 1 (2%)
Renal Tubule, Hyperplasia, Focal 1 (2%) 1 (2%) 5 (10%)
Renal Tubule, Pigmentation, Hemosiderin 1 (2%) 48 (96%) 49 (98%)
Urinary Bladder (49) (49) (50)
Inflammation, Chronic 1 (2%)
Submucosa, Inflammation, Granulomatous 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05043-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 17:45:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .0125 G/ .025G/KG
72 VM KG 72LM 72HM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Scheduled Sacrifice 9 10 10
Early Deaths
Moribund 15 11 19
Dead 12 16 15
Accident 1
Gavage Death 1
Survivors
Dead 1
Terminal Sacrifice 23 20 16
Terminal Sacrifice 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (18) (50)
Periesophageal Tissue, Inflammation,
Suppurative 1 (6%)
Intestine Large, Cecum (11) (18) (22)
Parasite Metazoan 1 (9%)
Colon, Parasite Metazoan 1 (5%)
Intestine Large, Colon (11) (19) (22)
Parasite Metazoan 4 (36%) 2 (11%) 2 (9%)
Intestine Large, Rectum (11) (19) (21)
Parasite Metazoan 1 (9%) 1 (5%)
Intestine Small, Duodenum (47) (50) (50)
Lamina Propria, Pigmentation 50 (100%) 50 (100%)
Liver (50) (31) (50)
Basophilic Focus 21 (42%) 5 (16%) 17 (34%)
Clear Cell Focus 10 (20%) 7 (14%)
Congestion 2 (4%) 2 (6%) 4 (8%)
Fatty Change 26 (52%) 18 (58%) 17 (34%)
Fibrosis, Focal 1 (2%)
Hematopoietic Cell Proliferation 1 (3%)
Hepatodiaphragmatic Nodule 4 (8%) 5 (16%) 1 (2%)
Inflammation, Acute, Focal 1 (2%)
Inflammation, Chronic 1 (2%)
Necrosis 1 (2%)
Bile Duct, Hyperplasia 40 (80%) 20 (65%) 41 (82%)
Centrilobular, Degeneration 1 (2%)
Mesentery (7) (8) (4)
Artery, Inflammation, Acute 1 (25%)
Artery, Inflammation, Chronic 1 (13%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05043-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 17:45:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .0125 G/ .025G/KG
72 VM KG 72LM 72HM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Fat, Necrosis, Focal 5 (71%) 5 (63%) 4 (100%)
Pancreas (50) (22) (50)
Inflammation, Chronic 1 (2%) 1 (2%)
Acinus, Atrophy 8 (16%) 3 (14%) 3 (6%)
Acinus, Hyperplasia 5 (10%) 2 (4%)
Acinus, Hyperplasia, Focal 3 (6%) 4 (8%)
Acinus, Vacuolization Cytoplasmic 1 (2%)
Artery, Hypertrophy 2 (4%) 1 (2%)
Artery, Inflammation, Chronic 1 (2%) 1 (5%) 1 (2%)
Artery, Thrombosis 1 (2%)
Artery, Media, Hyperplasia 1 (5%)
Duct, Ectasia, Multifocal 1 (5%)
Serosa, Inflammation, Chronic 1 (2%)
Stomach (49) (23) (50)
Serosa, Inflammation, Acute 1 (2%)
Stomach, Forestomach (49) (23) (50)
Acanthosis 4 (8%) 1 (4%) 4 (8%)
Pigmentation 2 (9%) 6 (12%)
Pigmentation, Focal 1 (4%)
Ulcer 2 (4%) 3 (13%) 6 (12%)
Stomach, Glandular (49) (23) (50)
Mineralization 1 (2%) 1 (2%)
Necrosis 1 (2%) 1 (2%)
Muscularis, Inflammation, Chronic 1 (4%)
Serosa, Inflammation, Chronic 1 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (22) (50)
Cardiomyopathy 40 (80%) 10 (45%) 30 (60%)
Fibrosis 1 (2%)
Inflammation, Chronic 2 (9%)
Artery, Myocardium, Inflammation, Chronic 1 (5%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50)
Cyst 1 (2%)
Degeneration 1 (2%)
Hyperplasia, Focal 5 (10%) 5 (10%)
Hypertrophy 4 (8%) 1 (2%)
Hypertrophy, Focal 1 (2%) 1 (2%)
Metaplasia, Osseous 1 (2%)
Vacuolization Cytoplasmic 7 (14%) 12 (24%) 12 (24%)
Vacuolization Cytoplasmic, Diffuse 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05043-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 17:45:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .0125 G/ .025G/KG
72 VM KG 72LM 72HM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Vacuolization Cytoplasmic, Focal 1 (2%) 2 (4%)
Adrenal Gland, Medulla (49) (50) (50)
Hyperplasia, Focal 2 (4%) 2 (4%) 5 (10%)
Islets, Pancreatic (50) (22) (50)
Hyperplasia 1 (2%) 2 (4%)
Parathyroid Gland (48) (12) (44)
Hyperplasia 1 (2%)
Pituitary Gland (50) (50) (49)
Pars Distalis, Angiectasis, Focal 1 (2%) 1 (2%)
Pars Distalis, Cyst 2 (4%) 1 (2%)
Pars Distalis, Hyperplasia, Focal 3 (6%) 10 (20%) 8 (16%)
Thyroid Gland (50) (20) (50)
C-Cell, Hyperplasia 4 (8%) 1 (5%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (17) (24) (26)
Inflammation, Chronic 10 (59%) 4 (17%) 4 (15%)
Inflammation, Suppurative 1 (4%)
Duct, Cyst 1 (6%) 1 (4%)
Prostate (49) (19) (50)
Hyperplasia, Focal 1 (2%)
Inflammation, Chronic 1 (5%)
Inflammation, Subacute 1 (2%)
Inflammation, Suppurative 19 (39%) 5 (26%) 11 (22%)
Seminal Vesicle (50) (25) (50)
Dilatation 1 (2%)
Testes (50) (50) (50)
Interstitial Cell, Hyperplasia 2 (4%) 4 (8%)
Seminiferous Tubule, Degeneration 7 (14%) 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (50) (50) (50)
Lumbar, Hyperplasia, Lymphoid 1 (2%)
Mediastinal, Congestion 5 (10%) 2 (4%) 3 (6%)
Mediastinal, Cyst 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%)
Mediastinal, Pigmentation 1 (2%) 3 (6%) 1 (2%)
Pancreatic, Cyst 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05043-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 17:45:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .0125 G/ .025G/KG
72 VM KG 72LM 72HM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Pancreatic, Pigmentation 22 (44%) 21 (42%)
Renal, Congestion 1 (2%)
Renal, Pigmentation 1 (2%)
Lymph Node, Mandibular (49) (14) (47)
Hyperplasia, Plasma Cell 3 (6%) 1 (7%) 4 (9%)
Lymph Node, Mesenteric (49) (49) (50)
Congestion 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 1 (2%)
Necrosis, Focal 1 (2%)
Pigmentation 20 (41%) 22 (45%) 42 (84%)
Pigmentation, Hemosiderin 1 (2%)
Spleen (50) (29) (50)
Congestion 2 (7%)
Cyst 1 (2%)
Ectopic Tissue 1 (3%)
Fibrosis 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 1 (3%)
Hyperplasia, Nodular 1 (2%)
Hyperplasia, Re Cell 1 (3%)
Pigmentation, Hemosiderin 2 (4%) 1 (3%) 1 (2%)
Endothelium, Hyperplasia 2 (4%) 1 (2%)
Red Pulp, Atrophy 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (9) (10) (12)
Hyperplasia 1 (11%) 1 (8%)
Hyperplasia, Cystic 1 (11%) 1 (10%)
Inflammation, Focal, Granulomatous 1 (10%)
Duct, Cyst 1 (10%)
Duct, Hemorrhage, Chronic 1 (10%)
Skin (20) (26) (28)
Cyst Epithelial Inclusion 1 (5%) 1 (4%)
Hyperkeratosis 1 (5%) 1 (4%)
Head, Inflammation, Acute 1 (4%)
Subcutaneous Tissue, Hemorrhage 1 (5%) 1 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05043-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 17:45:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .0125 G/ .025G/KG
72 VM KG 72LM 72HM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (20) (50)
Lateral Ventricle, Hemorrhage 1 (2%)
Pons, Hemorrhage 1 (5%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (30) (50)
Adenomatosis 1 (2%)
Congestion 12 (24%) 22 (73%) 16 (32%)
Hemorrhage 1 (3%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Granulomatous 11 (22%) 1 (3%) 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%)
Alveolar Epithelium, Pigmentation 1 (2%)
Alveolus, Inflammation, Acute 1 (3%)
Interstitium, Inflammation, Chronic 1 (2%)
Perivascular, Inflammation, Chronic 1 (3%) 1 (2%)
Nose (12) (21) (21)
Nasolacrimal Duct, Inflammation, Chronic 4 (33%) 4 (19%) 1 (5%)
Sinus, Inflammation, Chronic 2 (10%)
Trachea (50) (19) (50)
Mucosa, Pigmentation 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (5) (5) (3)
Cataract 2 (40%) 1 (33%)
Anterior Chamber, Inflammation, Suppurative 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (50)
Congestion 4 (8%)
Cyst 1 (2%)
Necrosis, Focal 1 (2%)
Nephropathy 47 (94%) 46 (94%) 50 (100%)
Artery, Pelvis, Inflammation, Chronic 1 (2%)
Capsule, Developmental Malformation 1 (2%)
Renal Tubule, Hyperplasia, Focal 2 (4%) 6 (12%)
Renal Tubule, Pigmentation, Hemosiderin 1 (2%) 27 (55%) 42 (84%)
Urinary Bladder (50) (48) (50)
Concretion 1 (2%) 1 (2%)
Mucosa, Hyperplasia, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05043-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 09/05/94
Route: GAVAGE Time: 17:45:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .0125 G/ .025G/KG
72 VM KG 72LM 72HM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Wall, Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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