TDMS Study 05043-01 Pathology Tables
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
Facility: TSI Mason Research
Chemical CAS #: 137-09-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 4| 4| 7| 6| 7| 6| 7| 6| 7| 4| 7| 7| 4| 1| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 3| 5| 3| 3| 0| 5| 2| 3| 2| 3| 8| 3| 6| 1| 5| 3| 3| 5| 9| 3| 3| 3| 3| 0|
| 7| 5| 2| 5| 6| 4| 2| 1| 5| 7| 6| 0| 5| 8| 1| 2| 6| 6| 0| 3| 5| 5| 6| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + +|
Adenocarcinoma | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Mesentery | + + + |
Hemangiosarcoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + M + + + + + + M + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X |
Medulla, Osteosarcoma, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M + + + + + + M + + + + + + + + + + +|
Leukemia Mononuclear | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + M M + + + + M M M + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X |
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 4| 4| 7| 6| 7| 6| 7| 6| 7| 4| 7| 7| 4| 1| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 3| 5| 3| 3| 0| 5| 2| 3| 2| 3| 8| 3| 6| 1| 5| 3| 3| 5| 9| 3| 3| 3| 3| 0|
| 7| 5| 2| 5| 6| 4| 2| 1| 5| 7| 6| 0| 5| 8| 1| 2| 6| 6| 0| 3| 5| 5| 6| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + +|
Adenoma | X |
Adenoma, Moderate | |
Carcinoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + M + + + + + + + + + + +|
Leukemia Mononuclear | |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | |
Periovarian Tissue, Leukemia | |
Mononuclear | |
__________________________________________________________________________|
Oviduct | + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Polyp Stromal | X X X X |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Carcinoma, Metastatic,| |
Thyroid Gland | |
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Thymus | + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + +|
Carcinoma | X |
Fibroadenoma | X X X X X X X |
Fibroadenoma, Multiple | X X X |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 4| 4| 7| 6| 7| 6| 7| 6| 7| 4| 7| 7| 4| 1| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 3| 5| 3| 3| 0| 5| 2| 3| 2| 3| 8| 3| 6| 1| 5| 3| 3| 5| 9| 3| 3| 3| 3| 0|
| 7| 5| 2| 5| 6| 4| 2| 1| 5| 7| 6| 0| 5| 8| 1| 2| 6| 6| 0| 3| 5| 5| 6| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + +|
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | X X |
Subcutaneous Tissue, Leukemia | |
Mononuclear | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Carcinoma, Deep Invasion, | |
Metastatic, Pituitary Gland | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Nose | + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Lacrimal Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 7| 7| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 5| 8| 3| 3| 6| 3| 3| 3| 3| 4| 0| 8| 3| 0| 8|
| 5| 9| 0| 5| 6| 6| 6| 2| 6| 5| 2| 0| 6| 6| 7| 6| 6| 6| 6| 5| 9| 1| 6| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + A + |
__________________________________________________________________________|
Intestine Large, Cecum | + A + |
__________________________________________________________________________|
Intestine Large, Colon | + A + |
Adenocarcinoma | |
__________________________________________________________________________|
Intestine Large, Rectum | + A + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Mesentery | + |
Hemangiosarcoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | |
Medulla, Osteosarcoma, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + M + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
Pars Distalis, Adenoma | X X X X X X X X X |
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 7| 7| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 5| 8| 3| 3| 6| 3| 3| 3| 3| 4| 0| 8| 3| 0| 8|
| 5| 9| 0| 5| 6| 6| 6| 2| 6| 5| 2| 0| 6| 6| 7| 6| 6| 6| 6| 5| 9| 1| 6| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | X X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + |
Adenoma | |
Adenoma, Moderate | |
Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | |
Periovarian Tissue, Leukemia | |
Mononuclear | |
__________________________________________________________________________|
Oviduct | + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
Polyp Stromal | X X X X X X X |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + A + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + A + + + + +|
Deep Cervical, Carcinoma, Metastatic,| |
Thyroid Gland | X|
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + A + + M + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Thymus | + A + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + |
Carcinoma | |
Fibroadenoma | X X X X X |
Fibroadenoma, Multiple | X |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 7| 7| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 5| 8| 3| 3| 6| 3| 3| 3| 3| 4| 0| 8| 3| 0| 8|
| 5| 9| 0| 5| 6| 6| 6| 2| 6| 5| 2| 0| 6| 6| 7| 6| 6| 6| 6| 5| 9| 1| 6| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Leukemia | |
Mononuclear | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Carcinoma, Deep Invasion, | |
Metastatic, Pituitary Gland | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Nose | + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Lacrimal Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 4| 7| 7| 4| 2| 4| 7| | |
DAY ON TEST | 9| 3| 3| 5| 3| 3| 5| 4| 5| 3| | |
| 9| 6| 6| 0| 6| 6| 2| 6| 2| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 9 |
Adenocarcinoma | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 8 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 8 |
__________________________________________________________________________|____________|
Liver | + + + + + + + | 50 |
Leukemia Mononuclear | X X | 13 |
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Hemangiosarcoma | | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 21 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 48 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + | 50 |
Adenoma | | 1 |
Leukemia Mononuclear | X | 2 |
Medulla, Osteosarcoma, Metastatic, | | |
Uncertain Primary Site | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + | 47 |
Leukemia Mononuclear | | 1 |
Pheochromocytoma Benign | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M + + + | 38 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 4| 7| 7| 4| 2| 4| 7| | |
DAY ON TEST | 9| 3| 3| 5| 3| 3| 5| 4| 5| 3| | |
| 9| 6| 6| 0| 6| 6| 2| 6| 2| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Pars Distalis, Adenoma | X X X | 22 |
Pars Distalis, Carcinoma | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 50 |
C-Cell, Adenoma | X X X | 7 |
C-Cell, Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + | 12 |
Adenoma | | 1 |
Adenoma, Moderate | X | 1 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + | 49 |
Leukemia Mononuclear | X | 1 |
Osteosarcoma, Metastatic, Uncertain | | |
Primary Site | X | 1 |
Periovarian Tissue, Leukemia | | |
Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Oviduct | | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Polyp Stromal | X | 12 |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 8 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 49 |
Deep Cervical, Carcinoma, Metastatic,| | |
Thyroid Gland | | 1 |
Pancreatic, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + M M + + | 44 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + | 49 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 4| 7| 7| 4| 2| 4| 7| | |
DAY ON TEST | 9| 3| 3| 5| 3| 3| 5| 4| 5| 3| | |
| 9| 6| 6| 0| 6| 6| 2| 6| 2| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X | 12 |
Osteosarcoma, Metastatic, Uncertain | | |
Primary Site | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 27 |
Carcinoma | X X | 3 |
Fibroadenoma | | 12 |
Fibroadenoma, Multiple | X | 5 |
__________________________________________________________________________|____________|
Skin | + + | 12 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 3 |
Subcutaneous Tissue, Leukemia | | |
Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 9 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 50 |
Cerebrum, Carcinoma, Deep Invasion, | | |
Metastatic, Pituitary Gland | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 1 |
Leukemia Mononuclear | X | 6 |
__________________________________________________________________________|____________|
Nose | + + | 9 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 4| 7| 7| 4| 2| 4| 7| | |
DAY ON TEST | 9| 3| 3| 5| 3| 3| 5| 4| 5| 3| | |
| 9| 6| 6| 0| 6| 6| 2| 6| 2| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + | 50 |
Leukemia Mononuclear | X X | 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4| 4| 7| 6| 5| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 5| 3| 3| 5| 5| 2| 5| 0| 9| 4| 8| 3| 3| 1| 5| 4|
| 1| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 3| 0| 2| 2| 4| 4| 0| 0| 2| 2| 4| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.0125 G/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + M|
__________________________________________________________________________|
Intestine Large | + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + +|
Acinus, Adenoma | |
__________________________________________________________________________|
Salivary Glands | + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + +|
Leukemia Mononuclear | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + +|
Adenoma | |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + +|
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4| 4| 7| 6| 5| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 5| 3| 3| 5| 5| 2| 5| 0| 9| 4| 8| 3| 3| 1| 5| 4|
| 1| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 3| 0| 2| 2| 4| 4| 0| 0| 2| 2| 4| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.0125 G/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M|
Adenoma | |
Carcinoma | X X |
__________________________________________________________________________|
Ovary | + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Oviduct | + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + +|
Polyp Stromal | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + M + M|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Thymus | + + + M +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + + + +|
Fibroadenoma | X X X X X X X X X|
Fibroadenoma, Multiple | X X |
__________________________________________________________________________|
Skin | + + + + + +|
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Sarcoma, | |
Multiple | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + +|
Pons, Glioma NOS | X |
__________________________________________________________________________|
Spinal Cord | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Carcinoma, Metastatic, Thyroid Gland | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4| 4| 7| 6| 5| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 5| 3| 3| 5| 5| 2| 5| 0| 9| 4| 8| 3| 3| 1| 5| 4|
| 1| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 3| 0| 2| 2| 4| 4| 0| 0| 2| 2| 4| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.0125 G/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Leukemia Mononuclear | |
__________________________________________________________________________|
Nose | + + + + +|
__________________________________________________________________________|
Trachea | + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pelvis, Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + + + + M + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Papilloma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 3| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 5| 5| 3| 3| 6| 5| 5| 3| 3| 3| 3| 5| 3| 1| 1| 5| 4| 3| 3| 3| 3| 9|
| 2| 2| 2| 2| 0| 2| 2| 8| 0| 0| 2| 2| 2| 2| 0| 2| 6| 7| 2| 2| 2| 2| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.0125 G/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + |
__________________________________________________________________________|
Intestine Large | + + + A + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + A A |
__________________________________________________________________________|
Intestine Large, Colon | + + A A + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + A |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A A |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + |
__________________________________________________________________________|
Liver | + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Mesentery | + + + |
__________________________________________________________________________|
Pancreas | + + + |
Acinus, Adenoma | |
__________________________________________________________________________|
Salivary Glands | + + + |
__________________________________________________________________________|
Stomach | + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + |
Leukemia Mononuclear | X |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + |
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 3| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 5| 5| 3| 3| 6| 5| 5| 3| 3| 3| 3| 5| 3| 1| 1| 5| 4| 3| 3| 3| 3| 9|
| 2| 2| 2| 2| 0| 2| 2| 8| 0| 0| 2| 2| 2| 2| 0| 2| 6| 7| 2| 2| 2| 2| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.0125 G/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + |
Adenoma | X |
Carcinoma | X X |
__________________________________________________________________________|
Ovary | + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Oviduct | + |
__________________________________________________________________________|
Uterus | + + + |
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + M + + + +|
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Thymus | + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + M + + |
Fibroadenoma | X X X X X X |
Fibroadenoma, Multiple | X X X |
__________________________________________________________________________|
Skin | + + + |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Sarcoma, | |
Multiple | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + |
Pons, Glioma NOS | |
__________________________________________________________________________|
Spinal Cord | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + |
Alveolar/Bronchiolar Adenoma | |
Carcinoma, Metastatic, Thyroid Gland | X |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 3| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 5| 5| 3| 3| 6| 5| 5| 3| 3| 3| 3| 5| 3| 1| 1| 5| 4| 3| 3| 3| 3| 9|
| 2| 2| 2| 2| 0| 2| 2| 8| 0| 0| 2| 2| 2| 2| 0| 2| 6| 7| 2| 2| 2| 2| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.0125 G/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Leukemia Mononuclear | |
__________________________________________________________________________|
Nose | + + + |
__________________________________________________________________________|
Trachea | + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + +|
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pelvis, Leukemia Mononuclear | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Papilloma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 2| 9| | |
| 5| 5| 5| 5| 4| 5| 5| 5| 0| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
.0125 G/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 14 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 11 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 30 |
Leukemia Mononuclear | X X | 7 |
__________________________________________________________________________|____________|
Mesentery | + | 5 |
__________________________________________________________________________|____________|
Pancreas | + + + + + | 13 |
Acinus, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 12 |
__________________________________________________________________________|____________|
Stomach | + + + + | 14 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 14 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 13 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 13 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 15 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 15 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 15 |
Leukemia Mononuclear | X X | 3 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 14 |
Adenoma | | 1 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 11 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
Pars Distalis, Adenoma | X X X X | 26 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 12 |
C-Cell, Carcinoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 2| 9| | |
| 5| 5| 5| 5| 4| 5| 5| 5| 0| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
.0125 G/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + + + + | 17 |
Adenoma | | 1 |
Carcinoma | X | 5 |
__________________________________________________________________________|____________|
Ovary | + + + + | 15 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Oviduct | + + | 7 |
__________________________________________________________________________|____________|
Uterus | + + + + | 15 |
Polyp Stromal | X | 4 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 12 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 49 |
Pancreatic, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 10 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 20 |
Leukemia Mononuclear | X X | 7 |
__________________________________________________________________________|____________|
Thymus | M + + + | 11 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 29 |
Fibroadenoma | X | 16 |
Fibroadenoma, Multiple | | 5 |
__________________________________________________________________________|____________|
Skin | + + + + | 13 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Sarcoma, | | |
Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + M + | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 2| 9| | |
| 5| 5| 5| 5| 4| 5| 5| 5| 0| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
.0125 G/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Pons, Glioma NOS | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 17 |
Alveolar/Bronchiolar Adenoma | X | 1 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Nose | + + + + | 12 |
__________________________________________________________________________|____________|
Trachea | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 7 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
Pelvis, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
Papilloma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 4|
DAY ON TEST | 2| 2| 2| 4| 7| 3| 2| 2| 7| 5| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 5| 1|
| 9| 9| 9| 5| 1| 0| 9| 9| 9| 0| 0| 0| 0| 0| 1| 0| 0| 0| 3| 0| 0| 0| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
.025G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Mesentery | + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + M + + M + M M + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 4|
DAY ON TEST | 2| 2| 2| 4| 7| 3| 2| 2| 7| 5| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 5| 1|
| 9| 9| 9| 5| 1| 0| 9| 9| 9| 0| 0| 0| 0| 0| 1| 0| 0| 0| 3| 0| 0| 0| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
.025G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + +|
Adenoma | |
Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + M + + + + + + + + + +|
Mesothelioma Malignant | X |
Periovarian Tissue, Leukemia | |
Mononuclear | |
__________________________________________________________________________|
Oviduct | +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Polyp Stromal | X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Thymus | + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + +|
Fibroadenoma | X X X X X X |
Fibroadenoma, Multiple | X |
__________________________________________________________________________|
Skin | + + + + +|
Basal Cell Adenoma | X |
Sebaceous Gland, Adenoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Abdominal, Sarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 4|
DAY ON TEST | 2| 2| 2| 4| 7| 3| 2| 2| 7| 5| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 5| 1|
| 9| 9| 9| 5| 1| 0| 9| 9| 9| 0| 0| 0| 0| 0| 1| 0| 0| 0| 3| 0| 0| 0| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
.025G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Nose | + + M +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 2| 7| 6| 6| 4| 4| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 8| 5| 5| 3| 3| 0| 9| 5| 3| 3| 3| 5| 8| 3| 8| 6| 5| 5| 3| 3| 8| 7| 4|
| 0| 0| 7| 2| 0| 0| 0| 3| 5| 0| 1| 1| 1| 2| 2| 1| 1| 9| 0| 0| 1| 1| 8| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
.025G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + |
__________________________________________________________________________|
Intestine Large, Cecum | + |
__________________________________________________________________________|
Intestine Large, Colon | + |
Mesothelioma Malignant | |
__________________________________________________________________________|
Intestine Large, Rectum | M |
Mesothelioma Malignant | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + |
__________________________________________________________________________|
Intestine Small, Jejunum | M + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Mesentery | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + M + + + M +|
Leukemia Mononuclear | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + M + M M + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X |
Pars Distalis, Carcinoma | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X X X X |
C-Cell, Carcinoma | X X X|
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 2| 7| 6| 6| 4| 4| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 8| 5| 5| 3| 3| 0| 9| 5| 3| 3| 3| 5| 8| 3| 8| 6| 5| 5| 3| 3| 8| 7| 4|
| 0| 0| 7| 2| 0| 0| 0| 3| 5| 0| 1| 1| 1| 2| 2| 1| 1| 9| 0| 0| 1| 1| 8| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
.025G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + |
Adenoma | X |
Carcinoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
Periovarian Tissue, Leukemia | |
Mononuclear | |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Polyp Stromal | X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Thymus | + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + |
Fibroadenoma | X X X |
Fibroadenoma, Multiple | X |
__________________________________________________________________________|
Skin | + + |
Basal Cell Adenoma | |
Sebaceous Gland, Adenoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
__________________________________________________________________________|
Skeletal Muscle | |
Abdominal, Sarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 2| 7| 6| 6| 4| 4| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 8| 5| 5| 3| 3| 0| 9| 5| 3| 3| 3| 5| 8| 3| 8| 6| 5| 5| 3| 3| 8| 7| 4|
| 0| 0| 7| 2| 0| 0| 0| 3| 5| 0| 1| 1| 1| 2| 2| 1| 1| 9| 0| 0| 1| 1| 8| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
.025G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Nose | + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 5| 4| 4| | |
DAY ON TEST | 3| 3| 3| 2| 5| 3| 3| 2| 9| 5| | |
| 1| 1| 1| 3| 0| 1| 1| 6| 8| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
.025G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 9 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 7 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 7 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 7 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 11 |
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 28 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 49 |
Leukemia Mononuclear | X | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 48 |
Leukemia Mononuclear | X | 2 |
Pheochromocytoma Benign | X X | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M | 38 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 50 |
Pars Distalis, Adenoma | X X X X | 25 |
Pars Distalis, Carcinoma | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 5| 4| 4| | |
DAY ON TEST | 3| 3| 3| 2| 5| 3| 3| 2| 9| 5| | |
| 1| 1| 1| 3| 0| 1| 1| 6| 8| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
.025G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 50 |
Bilateral, C-Cell, Adenoma | | 1 |
C-Cell, Adenoma | X | 6 |
C-Cell, Carcinoma | | 3 |
Follicular Cell, Adenoma | | 2 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + | 9 |
Adenoma | | 1 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 49 |
Mesothelioma Malignant | | 1 |
Periovarian Tissue, Leukemia | | |
Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Oviduct | + + | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
Polyp Stromal | X | 9 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 7 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 50 |
Pancreatic, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + | 46 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 11 |
__________________________________________________________________________|____________|
Thymus | + + | 8 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + | 19 |
Fibroadenoma | X X | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 5| 4| 4| | |
DAY ON TEST | 3| 3| 3| 2| 5| 3| 3| 2| 9| 5| | |
| 1| 1| 1| 3| 0| 1| 1| 6| 8| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
.025G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Fibroadenoma, Multiple | | 2 |
__________________________________________________________________________|____________|
Skin | + + | 9 |
Basal Cell Adenoma | | 1 |
Sebaceous Gland, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 6 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Abdominal, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Carcinoma, Metastatic | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 7 |
__________________________________________________________________________|____________|
Nose | + + | 6 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | + | 3 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 11 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 3| 6| 4| 4| 7| 7| 5| 5| 4| 7| 7| 6| 7| 4| 7| 7| 7| 6| 4| 7| 7| 5| 4| 4|
DAY ON TEST | 2| 8| 4| 5| 5| 3| 3| 8| 6| 5| 3| 3| 7| 3| 5| 3| 3| 3| 5| 2| 3| 3| 2| 8| 4|
| 0| 0| 7| 6| 4| 4| 4| 7| 9| 4| 4| 4| 2| 4| 4| 6| 6| 6| 3| 6| 5| 7| 4| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
72 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + M + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Mesentery | + + + + + + |
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Acinus, Adenoma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
Extra Adrenal Tissue, Leukemia | |
Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pheochromocytoma Malignant | X X X X |
Pheochromocytoma Benign | X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 3| 6| 4| 4| 7| 7| 5| 5| 4| 7| 7| 6| 7| 4| 7| 7| 7| 6| 4| 7| 7| 5| 4| 4|
DAY ON TEST | 2| 8| 4| 5| 5| 3| 3| 8| 6| 5| 3| 3| 7| 3| 5| 3| 3| 3| 5| 2| 3| 3| 2| 8| 4|
| 0| 0| 7| 6| 4| 4| 4| 7| 9| 4| 4| 4| 2| 4| 4| 6| 6| 6| 3| 6| 5| 7| 4| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
72 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Carcinoma | |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
Serosa, Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + +|
Adenoma | |
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X |
Tunic, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + M + + M|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Sarcoma | |
Sarcoma, Poorly Differentiated | X|
__________________________________________________________________________|
Thymus | + + + + + + + M|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 3| 6| 4| 4| 7| 7| 5| 5| 4| 7| 7| 6| 7| 4| 7| 7| 7| 6| 4| 7| 7| 5| 4| 4|
DAY ON TEST | 2| 8| 4| 5| 5| 3| 3| 8| 6| 5| 3| 3| 7| 3| 5| 3| 3| 3| 5| 2| 3| 3| 2| 8| 4|
| 0| 0| 7| 6| 4| 4| 4| 7| 9| 4| 4| 4| 2| 4| 4| 6| 6| 6| 3| 6| 5| 7| 4| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
72 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M + + + + M M M|
Fibroadenoma | X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + +|
Basal Cell Adenoma | |
Keratoacanthoma | X |
Squamous Cell Carcinoma | |
Sebaceous Gland, Carcinoma | |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Nose | + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + +|
__________________________________________________________________________|
Harderian Gland | + +|
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Renal Tubule, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Serosa, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Mesothelioma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 2| 8| 3| 3| 0| 5| 5| 3| 3| 3| 7| 4| 3| 3| 5| 4| 7| 3| 3| 8| 5| 5|
| 7| 6| 6| 1| 1| 1| 6| 2| 6| 6| 7| 7| 7| 1| 9| 7| 7| 8| 2| 6| 7| 7| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
72 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + A + |
__________________________________________________________________________|
Intestine Large, Cecum | + A + |
__________________________________________________________________________|
Intestine Large, Colon | A + |
__________________________________________________________________________|
Intestine Large, Rectum | A + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + A + |
__________________________________________________________________________|
Intestine Small, Jejunum | A + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Mesentery | |
Leukemia Mononuclear | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Acinus, Adenoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + A + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
Extra Adrenal Tissue, Leukemia | |
Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + M + + + |
Leukemia Mononuclear | X |
Pheochromocytoma Malignant | X X |
Pheochromocytoma Benign | X X X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + |
Adenoma | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 2| 8| 3| 3| 0| 5| 5| 3| 3| 3| 7| 4| 3| 3| 5| 4| 7| 3| 3| 8| 5| 5|
| 7| 6| 6| 1| 1| 1| 6| 2| 6| 6| 7| 7| 7| 1| 9| 7| 7| 8| 2| 6| 7| 7| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
72 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Adenoma | X X X X X X X X |
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
Bilateral, C-Cell, Carcinoma | X |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + |
Serosa, Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + A + + + |
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + M + + + |
Adenoma | X X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X |
Tunic, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Sarcoma | X |
Sarcoma, Poorly Differentiated | |
__________________________________________________________________________|
Thymus | + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 2| 8| 3| 3| 0| 5| 5| 3| 3| 3| 7| 4| 3| 3| 5| 4| 7| 3| 3| 8| 5| 5|
| 7| 6| 6| 1| 1| 1| 6| 2| 6| 6| 7| 7| 7| 1| 9| 7| 7| 8| 2| 6| 7| 7| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
72 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + |
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + |
Basal Cell Adenoma | X |
Keratoacanthoma | |
Squamous Cell Carcinoma | X |
Sebaceous Gland, Carcinoma | |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Nose | A + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Renal Tubule, Carcinoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Serosa, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 4| 7| 7| 6| 6| 4| | |
DAY ON TEST | 9| 7| 2| 2| 5| 3| 3| 8| 5| 5| | |
| 1| 0| 5| 2| 4| 6| 7| 6| 9| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
72 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 13 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + | 11 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + | 47 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A A + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 7 |
__________________________________________________________________________|____________|
Mesentery | + | 7 |
Leukemia Mononuclear | X | 2 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Acinus, Adenoma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 40 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 50 |
Extra Adrenal Tissue, Leukemia | | |
Mononuclear | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 49 |
Leukemia Mononuclear | X | 2 |
Pheochromocytoma Malignant | X | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 4| 7| 7| 6| 6| 4| | |
DAY ON TEST | 9| 7| 2| 2| 5| 3| 3| 8| 5| 5| | |
| 1| 0| 5| 2| 4| 6| 7| 6| 9| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
72 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Benign | X X | 8 |
Bilateral, Pheochromocytoma Benign | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 50 |
Adenoma | X | 3 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 50 |
Pars Distalis, Adenoma | X X X X | 23 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 50 |
Bilateral, C-Cell, Carcinoma | | 1 |
C-Cell, Adenoma | | 4 |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 50 |
Serosa, Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 17 |
Adenoma | | 1 |
Carcinoma | X X | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 49 |
Adenoma | | 2 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 50 |
Bilateral, Interstitial Cell, Adenoma| X | 25 |
Interstitial Cell, Adenoma | X X X X X X | 17 |
Tunic, Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 11 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 50 |
Mediastinal, Leukemia Mononuclear | X | 3 |
Pancreatic, Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 4| 7| 7| 6| 6| 4| | |
DAY ON TEST | 9| 7| 2| 2| 5| 3| 3| 8| 5| 5| | |
| 1| 0| 5| 2| 4| 6| 7| 6| 9| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
72 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + | 49 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 49 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 6 |
Sarcoma | | 1 |
Sarcoma, Poorly Differentiated | | 1 |
__________________________________________________________________________|____________|
Thymus | + + M + + | 17 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M + + | 9 |
Fibroadenoma | X | 4 |
__________________________________________________________________________|____________|
Skin | + + M + | 20 |
Basal Cell Adenoma | | 1 |
Keratoacanthoma | X | 2 |
Squamous Cell Carcinoma | | 1 |
Sebaceous Gland, Carcinoma | X | 1 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 13 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 2 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Nose | + + + + | 12 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 4| 7| 7| 6| 6| 4| | |
DAY ON TEST | 9| 7| 2| 2| 5| 3| 3| 8| 5| 5| | |
| 1| 0| 5| 2| 4| 6| 7| 6| 9| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
72 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
Renal Tubule, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Serosa, Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 7 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 39
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 2| 7| 4| 4| 4| 7| 1| 7| 6| 4| 7| 7| 6| 5| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 8| 2| 6| 5| 5| 2| 4| 2| 3| 5| 2| 3| 1| 9| 6| 3| 3| 6| 5| 3| 3| 3| 3| 3| 5|
| 6| 9| 1| 6| 4| 9| 7| 9| 9| 6| 9| 0| 1| 7| 3| 0| 0| 8| 4| 5| 0| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.0125 G/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
Serosa, Mesothelioma Malignant | |
__________________________________________________________________________|
Mesentery | + + |
Mesothelioma Malignant | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + |
Acinus, Adenoma, Multiple | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + |
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | M M M + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Adenoma | X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + |
C-Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 2| 7| 4| 4| 4| 7| 1| 7| 6| 4| 7| 7| 6| 5| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 8| 2| 6| 5| 5| 2| 4| 2| 3| 5| 2| 3| 1| 9| 6| 3| 3| 6| 5| 3| 3| 3| 3| 3| 5|
| 6| 9| 1| 6| 4| 9| 7| 9| 9| 6| 9| 0| 1| 7| 3| 0| 0| 8| 4| 5| 0| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.0125 G/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Serosa, Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + |
Adenoma | |
Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X |
Tunic, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M M |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + |
Hemangiosarcoma | X |
Leukemia Mononuclear | X X X |
Sarcoma | X X |
__________________________________________________________________________|
Thymus | + + + + + M + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M M M M + |
__________________________________________________________________________|
Skin | + + + + + + + + + |
Basal Cell Adenoma | |
Squamous Cell Papilloma | |
Trichoepithelioma | |
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + |
Glioma NOS | |
Squamous Cell Carcinoma, Early | |
Invasion, Metastatic, Zymbal's | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 2| 7| 4| 4| 4| 7| 1| 7| 6| 4| 7| 7| 6| 5| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 8| 2| 6| 5| 5| 2| 4| 2| 3| 5| 2| 3| 1| 9| 6| 3| 3| 6| 5| 3| 3| 3| 3| 3| 5|
| 6| 9| 1| 6| 4| 9| 7| 9| 9| 6| 9| 0| 1| 7| 3| 0| 0| 8| 4| 5| 0| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.0125 G/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Gland | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + |
Leukemia Mononuclear | |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | |
__________________________________________________________________________|
Nose | + + + + + + + + |
Nares, Squamous Cell Papilloma | |
__________________________________________________________________________|
Trachea | + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Serosa, Mesothelioma Malignant | |
Transitional Epithelium, Carcinoma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 7| 7| 6| 6| 4| 7| 7| 6| 6| 4| 7| 6| 4| 4| 4| 5| 4| 5| 4| 2|
DAY ON TEST | 3| 7| 8| 8| 6| 3| 3| 8| 3| 5| 3| 3| 8| 4| 5| 3| 8| 6| 5| 5| 8| 5| 6| 5| 9|
| 3| 2| 8| 2| 0| 3| 3| 7| 9| 4| 3| 3| 6| 8| 4| 3| 1| 7| 6| 4| 1| 6| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.0125 G/ | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + M|
__________________________________________________________________________|
Intestine Large | + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + A|
Leukemia Mononuclear | X |
Serosa, Mesothelioma Malignant | X |
__________________________________________________________________________|
Mesentery | + + + + |
Mesothelioma Malignant | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + M|
Acinus, Adenoma, Multiple | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | X X |
Pheochromocytoma Benign | X X |
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + M|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + M M M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + A|
C-Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + M|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 7| 7| 6| 6| 4| 7| 7| 6| 6| 4| 7| 6| 4| 4| 4| 5| 4| 5| 4| 2|
DAY ON TEST | 3| 7| 8| 8| 6| 3| 3| 8| 3| 5| 3| 3| 8| 4| 5| 3| 8| 6| 5| 5| 8| 5| 6| 5| 9|
| 3| 2| 8| 2| 0| 3| 3| 7| 9| 4| 3| 3| 6| 8| 4| 3| 1| 7| 6| 4| 1| 6| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.0125 G/ | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Serosa, Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + +|
Adenoma | X X |
Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X |
Tunic, Mesothelioma Malignant | X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | M + M + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + +|
Hemangiosarcoma | |
Leukemia Mononuclear | X |
Sarcoma | |
__________________________________________________________________________|
Thymus | + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + +|
Basal Cell Adenoma | |
Squamous Cell Papilloma | |
Trichoepithelioma | X |
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + +|
Glioma NOS | X |
Squamous Cell Carcinoma, Early | |
Invasion, Metastatic, Zymbal's | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 7| 7| 6| 6| 4| 7| 7| 6| 6| 4| 7| 6| 4| 4| 4| 5| 4| 5| 4| 2|
DAY ON TEST | 3| 7| 8| 8| 6| 3| 3| 8| 3| 5| 3| 3| 8| 4| 5| 3| 8| 6| 5| 5| 8| 5| 6| 5| 9|
| 3| 2| 8| 2| 0| 3| 3| 7| 9| 4| 3| 3| 6| 8| 4| 3| 1| 7| 6| 4| 1| 6| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.0125 G/ | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Gland | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | X |
__________________________________________________________________________|
Nose | + + + + + + + + +|
Nares, Squamous Cell Papilloma | X |
__________________________________________________________________________|
Trachea | + + + + + + + A|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + A + + + A + + + +|
Serosa, Mesothelioma Malignant | X |
Transitional Epithelium, Carcinoma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X X X |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 0| 5| 0| 5| 3| 3| 3| 0| 0| | |
| 3| 8| 3| 8| 0| 3| 3| 3| 4| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.0125 G/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A | 18 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A | 19 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 19 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A | 18 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A | 18 |
__________________________________________________________________________|____________|
Liver | + + + + + | 31 |
Leukemia Mononuclear | | 4 |
Serosa, Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 8 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + | 22 |
Acinus, Adenoma, Multiple | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 20 |
__________________________________________________________________________|____________|
Stomach | + + + + + | 23 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 23 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 23 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 22 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 50 |
Pheochromocytoma Malignant | | 2 |
Pheochromocytoma Benign | X X | 7 |
Bilateral, Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 22 |
Adenoma | X | 3 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M | 12 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 50 |
Pars Distalis, Adenoma | X X X X X X | 17 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 20 |
C-Cell, Adenoma | X | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 0| 5| 0| 5| 3| 3| 3| 0| 0| | |
| 3| 8| 3| 8| 0| 3| 3| 3| 4| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.0125 G/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + | 20 |
Serosa, Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 24 |
Adenoma | | 2 |
Carcinoma | X | 3 |
__________________________________________________________________________|____________|
Prostate | M + + + | 19 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 25 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 50 |
Bilateral, Interstitial Cell, Adenoma| X X X X | 25 |
Interstitial Cell, Adenoma | X X X X X X | 17 |
Tunic, Mesothelioma Malignant | | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 20 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | | 2 |
Pancreatic, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M + | 14 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 49 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 29 |
Hemangiosarcoma | | 1 |
Leukemia Mononuclear | | 4 |
Sarcoma | | 2 |
__________________________________________________________________________|____________|
Thymus | + M M + | 17 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M M | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 26 |
Basal Cell Adenoma | X | 1 |
Squamous Cell Papilloma | X | 1 |
Trichoepithelioma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 19 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 0| 5| 0| 5| 3| 3| 3| 0| 0| | |
| 3| 8| 3| 8| 0| 3| 3| 3| 4| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.0125 G/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 20 |
Glioma NOS | | 1 |
Squamous Cell Carcinoma, Early | | |
Invasion, Metastatic, Zymbal's | | |
Gland | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + | 30 |
Leukemia Mononuclear | | 1 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Gland | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + | 21 |
Nares, Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + | 19 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 5 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 48 |
Serosa, Mesothelioma Malignant | | 1 |
Transitional Epithelium, Carcinoma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 4 |
Mesothelioma Malignant | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 5| 5| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 6| 5| 4| 4|
DAY ON TEST | 3| 3| 6| 1| 9| 5| 3| 2| 5| 5| 5| 3| 3| 1| 9| 3| 3| 3| 4| 5| 3| 4| 8| 6| 5|
| 3| 3| 2| 0| 2| 6| 3| 5| 3| 4| 6| 3| 3| 5| 5| 3| 3| 2| 1| 4| 4| 8| 8| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.025G/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + |
Serosa, Sarcoma, Metastatic | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Mesentery | + + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
Acinus, Adenoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Tongue | + |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 5| 5| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 6| 5| 4| 4|
DAY ON TEST | 3| 3| 6| 1| 9| 5| 3| 2| 5| 5| 5| 3| 3| 1| 9| 3| 3| 3| 4| 5| 3| 4| 8| 6| 5|
| 3| 3| 2| 0| 2| 6| 3| 5| 3| 4| 6| 3| 3| 5| 5| 3| 3| 2| 1| 4| 4| 8| 8| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.025G/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + |
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
C-Cell, Adenoma | X |
C-Cell, Adenoma, Mild | |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + |
Serosa, Sarcoma, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + |
Adenoma | X |
Carcinoma | X X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + |
Adenoma | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Mediastinal, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + M + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
Sarcoma | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 5| 5| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 6| 5| 4| 4|
DAY ON TEST | 3| 3| 6| 1| 9| 5| 3| 2| 5| 5| 5| 3| 3| 1| 9| 3| 3| 3| 4| 5| 3| 4| 8| 6| 5|
| 3| 3| 2| 0| 2| 6| 3| 5| 3| 4| 6| 3| 3| 5| 5| 3| 3| 2| 1| 4| 4| 8| 8| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.025G/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Thymus | + + + + + M + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + M + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + |
Basal Cell Adenoma | |
Keratoacanthoma | X X |
Keratoacanthoma, Multiple | |
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Sarcoma, | |
Metastatic, Uncertain Primary | |
Site | |
Subcutaneous Tissue, Schwannoma | |
Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
Abdominal, Sarcoma | |
Hindlimb, Sarcoma, Metastatic, | |
Uncertain Primary Site | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Astrocytoma Malignant | X |
Granular Cell Tumor Benign | X |
Leukemia Mononuclear | |
Cerebellum, Leukemia Mononuclear | X |
Cerebrum, Leukemia Mononuclear | X |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X X X |
Carcinoma, Metastatic, Zymbal's Gland| |
Leukemia Mononuclear | X X X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 5| 5| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 6| 5| 4| 4|
DAY ON TEST | 3| 3| 6| 1| 9| 5| 3| 2| 5| 5| 5| 3| 3| 1| 9| 3| 3| 3| 4| 5| 3| 4| 8| 6| 5|
| 3| 3| 2| 0| 2| 6| 3| 5| 3| 4| 6| 3| 3| 5| 5| 3| 3| 2| 1| 4| 4| 8| 8| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.025G/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + M + + + |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + M |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Sarcoma, Metastatic | |
Renal Tubule, Adenoma | X |
Transitional Epithelium, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 6| 7| 6| 5| 7| 7| 6| 5| 4| 7| 4| 4| 3| 3| 6| 6| 6| 4| 4|
DAY ON TEST | 3| 2| 7| 4| 5| 3| 1| 3| 4| 1| 3| 3| 9| 6| 3| 3| 8| 7| 6| 2| 8| 6| 5| 5| 5|
| 5| 8| 7| 6| 6| 5| 0| 4| 4| 2| 5| 4| 4| 1| 3| 4| 9| 5| 0| 7| 0| 7| 3| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.025G/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + |
Serosa, Sarcoma, Metastatic | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
Acinus, Adenoma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Pheochromocytoma Malignant | X X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 6| 7| 6| 5| 7| 7| 6| 5| 4| 7| 4| 4| 3| 3| 6| 6| 6| 4| 4|
DAY ON TEST | 3| 2| 7| 4| 5| 3| 1| 3| 4| 1| 3| 3| 9| 6| 3| 3| 8| 7| 6| 2| 8| 6| 5| 5| 5|
| 5| 8| 7| 6| 6| 5| 0| 4| 4| 2| 5| 4| 4| 1| 3| 4| 9| 5| 0| 7| 0| 7| 3| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.025G/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + M + + + + + + + M M + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X |
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + |
C-Cell, Adenoma | X |
C-Cell, Adenoma, Mild | X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + |
Serosa, Sarcoma, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + |
Adenoma | X |
Carcinoma | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + |
Adenoma | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + M + + + + |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 6| 7| 6| 5| 7| 7| 6| 5| 4| 7| 4| 4| 3| 3| 6| 6| 6| 4| 4|
DAY ON TEST | 3| 2| 7| 4| 5| 3| 1| 3| 4| 1| 3| 3| 9| 6| 3| 3| 8| 7| 6| 2| 8| 6| 5| 5| 5|
| 5| 8| 7| 6| 6| 5| 0| 4| 4| 2| 5| 4| 4| 1| 3| 4| 9| 5| 0| 7| 0| 7| 3| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.025G/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M M M M M + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + |
Basal Cell Adenoma | X |
Keratoacanthoma | X |
Keratoacanthoma, Multiple | X |
Squamous Cell Carcinoma | X |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Sarcoma, | |
Metastatic, Uncertain Primary | |
Site | |
Subcutaneous Tissue, Schwannoma | |
Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
Abdominal, Sarcoma | X |
Hindlimb, Sarcoma, Metastatic, | |
Uncertain Primary Site | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + |
Astrocytoma Malignant | |
Granular Cell Tumor Benign | |
Leukemia Mononuclear | X |
Cerebellum, Leukemia Mononuclear | |
Cerebrum, Leukemia Mononuclear | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | |
Carcinoma, Metastatic, Zymbal's Gland| X |
Leukemia Mononuclear | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 6| 7| 6| 5| 7| 7| 6| 5| 4| 7| 4| 4| 3| 3| 6| 6| 6| 4| 4|
DAY ON TEST | 3| 2| 7| 4| 5| 3| 1| 3| 4| 1| 3| 3| 9| 6| 3| 3| 8| 7| 6| 2| 8| 6| 5| 5| 5|
| 5| 8| 7| 6| 6| 5| 0| 4| 4| 2| 5| 4| 4| 1| 3| 4| 9| 5| 0| 7| 0| 7| 3| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.025G/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Sarcoma, Metastatic | |
Renal Tubule, Adenoma | |
Transitional Epithelium, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 5| 5| 4| 4| 4| | |
DAY ON TEST | 3| 3| 2| 7| 5| 1| 0| 9| 6| 5| | |
| 4| 4| 5| 5| 6| 2| 6| 2| 2| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
.025G/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 23 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 22 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 22 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 21 |
Serosa, Sarcoma, Metastatic | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 20 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 5 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | X | 1 |
__________________________________________________________________________|____________|
Mesentery | | 4 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | X | 1 |
Acinus, Adenoma | X X | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 37 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 57
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 5| 5| 4| 4| 4| | |
DAY ON TEST | 3| 3| 2| 7| 5| 1| 0| 9| 6| 5| | |
| 4| 4| 5| 5| 6| 2| 6| 2| 2| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
.025G/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X | 2 |
Pheochromocytoma Malignant | | 3 |
Pheochromocytoma Benign | X | 7 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 50 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 49 |
Leukemia Mononuclear | X | 1 |
Pars Distalis, Adenoma | X | 14 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 50 |
C-Cell, Adenoma | | 2 |
C-Cell, Adenoma, Mild | | 1 |
C-Cell, Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 50 |
Serosa, Sarcoma, Metastatic, | | |
Uncertain Primary Site | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 26 |
Adenoma | | 2 |
Carcinoma | | 2 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 50 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 50 |
Bilateral, Interstitial Cell, Adenoma| X X X X X | 35 |
Interstitial Cell, Adenoma | X X X | 11 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 21 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 58
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 5| 5| 4| 4| 4| | |
DAY ON TEST | 3| 3| 2| 7| 5| 1| 0| 9| 6| 5| | |
| 4| 4| 5| 5| 6| 2| 6| 2| 2| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
.025G/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Leukemia Mononuclear | X | 2 |
Pancreatic, Leukemia Mononuclear | X | 1 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + | 47 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 5 |
Sarcoma | | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + | 24 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M + | 12 |
__________________________________________________________________________|____________|
Skin | + + + + + | 28 |
Basal Cell Adenoma | | 1 |
Keratoacanthoma | | 3 |
Keratoacanthoma, Multiple | | 1 |
Squamous Cell Carcinoma | | 1 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Sarcoma, | | |
Metastatic, Uncertain Primary | | |
Site | X | 1 |
Subcutaneous Tissue, Schwannoma | | |
Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 20 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Abdominal, Sarcoma | | 1 |
Hindlimb, Sarcoma, Metastatic, | | |
Uncertain Primary Site | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 05043-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/10/97
Route: GAVAGE Time: 08:06:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 5| 5| 4| 4| 4| | |
DAY ON TEST | 3| 3| 2| 7| 5| 1| 0| 9| 6| 5| | |
| 4| 4| 5| 5| 6| 2| 6| 2| 2| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
.025G/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Astrocytoma Malignant | | 1 |
Granular Cell Tumor Benign | | 1 |
Leukemia Mononuclear | X | 2 |
Cerebellum, Leukemia Mononuclear | | 1 |
Cerebrum, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 3 |
Carcinoma, Metastatic, Zymbal's Gland| | 1 |
Leukemia Mononuclear | X | 5 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + | 21 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 3 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
Sarcoma, Metastatic | X | 1 |
Renal Tubule, Adenoma | | 1 |
Transitional Epithelium, Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
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