TDMS Study 05043-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/05/94
EXP: 05043 2,4-DIAMINOPHENOL DIHYDROCHLORIDE TIME: 17:53:59
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 60026
CONT: N01CP9561903 CAS: 137-09-7
PATHOLOGIST: S. WYAND S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/05/94
EXP: 05043 2,4-DIAMINOPHENOL DIHYDROCHLORIDE TIME: 17:53:59
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 60026
CONT: N01CP9561903 CAS: 137-09-7
PATHOLOGIST: S. WYAND S. EUSTIS
2,4-DIAMINOPHENOL DIHYDROCHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE 72 |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 27 CENSORED DEATHS 9 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 380 426 440 456 481 522 524 525 549 569 |
| 570 576 587 591 642 647 653 658 659 671 |
| 672 681 685 686 702 720 721 |
| CENSORED DEATHS |
| 454 454 454 454 454 454 454 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = .0125 G/KG 72 |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 27 CENSORED DEATHS 12 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 291 360 435 450 454 461 463 467 482 488 |
| 503 561 568 581 597 604 608 611 639 639 |
| 648 653 672 681 686 687 708 |
| CENSORED DEATHS |
| 147 286 454 454 454 454 456 456 456 456 |
| 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = .025G/KG72 |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 34 CENSORED DEATHS 10 TERMINAL 16 |
| |
| UNCENSORED DEATHS |
| 327 360 433 462 468 475 489 492 492 506 |
| 510 512 512 541 546 561 562 575 588 595 |
| 610 632 644 648 653 653 667 677 680 694 |
| 715 725 725 728 |
| CENSORED DEATHS |
| 454 454 454 454 456 456 456 456 456 456 |
| |
==================================================================================
2,4-DIAMINOPHENOL DIHYDROCHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE 72 | 100.0 100.0 100.0 100.0 98.3 91.1 85.2 73.3 63.4 47.5 |
| | |
| | |
|.0125 | 100.0 100.0 100.0 96.6 96.6 82.9 78.6 68.0 55.3 44.6 |
|G/KG 72 | |
| | |
|.025G/KG72 | 100.0 100.0 100.0 96.7 96.7 88.9 72.8 60.6 48.5 32.3 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 72 .0125 .025G/KG72 |
| G/KG 72 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 47.5% 44.6% 32.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.120 P=0.667 P=0.125 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 592.3 555.4 572.3 |
|NATURAL DEATHS (C) | (18.7) (21.1) (18.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 626.3 588.2 594.6 |
|(STANDARD ERROR) | (15.0) (18.6) (15.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
2,4-DIAMINOPHENOL DIHYDROCHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE 72 |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 20 CENSORED DEATHS 10 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 193 199 245 246 421 481 536 604 627 667 |
| 668 680 680 682 704 708 709 709 711 717 |
| CENSORED DEATHS |
| 450 450 450 452 452 452 452 452 452 452 |
| |
|--------------------------------------------------------------------------------|
| DOSE = .0125 G/KG 72 |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 18 CENSORED DEATHS 10 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 342 422 434 443 480 498 540 568 610 617 |
| 620 625 653 690 694 704 714 716 |
| CENSORED DEATHS |
| 450 450 450 450 450 452 452 452 452 452 |
| |
|--------------------------------------------------------------------------------|
| DOSE = .025G/KG 72 |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 18 CENSORED DEATHS 11 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 379 411 498 526 570 571 645 645 653 669 |
| 676 681 687 688 695 703 711 723 |
| CENSORED DEATHS |
| 282 450 450 450 450 450 450 450 452 452 |
| 452 |
| |
==================================================================================
2,4-DIAMINOPHENOL DIHYDROCHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE 72 | 100.0 100.0 93.3 93.3 91.7 89.6 87.6 85.6 83.5 61.1 |
| | |
| | |
|.0125 | 100.0 100.0 100.0 98.3 96.7 91.3 87.2 85.2 75.1 64.9 |
|G/KG 72 | |
| | |
|.025G/KG 72| 100.0 100.0 100.0 100.0 96.6 96.6 92.5 88.4 82.2 63.7 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 72 .0125 .025G/KG 72 |
| G/KG 72 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 61.1% 64.9% 63.7% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.772N P=0.871N P=0.843N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 559.4 576.1 618.4 |
|NATURAL DEATHS (C) | (42.8) (27.3) (24.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 626.2 636.8 642.0 |
|(STANDARD ERROR) | (19.9) (16.0) (16.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
2,4-DIAMINOPHENOL DIHYDROCHLORIDE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE 72 = 1
.0125 G/KG 72 = 2
.025G/KG72 = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1
| 2 3 2 1 131
| 31 21
| 213 1
90 + 22313 1
| 33
P | 2 2 1 1
E | 223 3 1 1
R 80 + 2 233 11
C | 2 2211
E | 3 3 221 1
N | 2 12 11
T 70 + 3 3 22 11
| 3 3
S | 33 22 2 1 1
U | 3 3 11
R 60 + 3 3 22 1 1
V | 3 3322
I | 332 2
V | 33 2 1 1 1
A 50 + 22
L | 3 33 2 21 1
| 33 2 2
| 3 3
40 + 3 3
| 33
|
| 3 3
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 20 obs hidden.
2,4-DIAMINOPHENOL DIHYDROCHLORIDE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE 72 = 1
.0125 G/KG 72 = 2
.025G/KG 72 = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 3
| 11 2 3 3 2
|
| 1 1 3 22 3
95 + 11 2 2 3 3
| 1 1 2 2
| 3 3
| 1 1 2
P 90 + 1 1
E | 2 2 3 3
R | 12 2 1
C |
E 85 + 2 12 1
N | 221 33 1
T | 3 3
|
S 80 + 131
U | 22
R | 2 2 33
V | 33
I 75 + 2 2
V | 1 1
A | 22
L | 211
70 + 33
| 22
| 322
| 3 3
65 + 2 2
| 113 3
|
| 1 1
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.
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