TDMS Study 05044-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
4-VINYL-1-CYCLOHEXENE DIEPOXIDE
NTP Experiment-Test: 05044-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/06/94
Route: DERMAL,SOLUTION Time: 19:22:53
Facility: Battelle Columbus Laboratory
Chemical CAS #: 106-87-6
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05044-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 09/06/94
Route: DERMAL,SOLUTION Time: 19:22:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/ML 25 MG/ML 50 MG/ML 100 MG/
ML
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund 3 3 8 29
Dead 3 7 7 9
Accident 1
Drowned 1 1
Survivors
Terminal Sacrifice 30 31 14 10
Moribund 7 7 15 2
Dead 4 1 6
Accidently Killed 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (48) (49) (48) (49)
Inflammation, Chronic Active 1 (2%)
Intestine Large, Colon (50) (50) (50) (50)
Amyloid Deposition 1 (2%)
Inflammation, Necrotizing 1 (2%)
Intestine Small, Duodenum (49) (50) (50) (50)
Inflammation, Necrotizing 1 (2%)
Intestine Small, Jejunum (50) (50) (50) (50)
Amyloid Deposition 1 (2%)
Necrosis, Coagulative 1 (2%)
Liver (50) (50) (50) (50)
Amyloid Deposition 1 (2%) 1 (2%)
Angiectasis 1 (2%) 1 (2%)
Basophilic Focus 1 (2%) 1 (2%)
Cyst 1 (2%) 2 (4%)
Degeneration, Cystic 2 (4%)
Erythrophagocytosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 3 (6%) 2 (4%)
Hepatodiaphragmatic Nodule 1 (2%)
Inclusion Body Intracytoplasmic 2 (4%) 2 (4%) 2 (4%) 1 (2%)
Inflammation, Chronic Active, Multifocal 6 (12%) 5 (10%)
Necrosis, Coagulative, Multifocal 2 (4%) 1 (2%) 4 (8%) 8 (16%)
Necrosis, Caseous, Multifocal 1 (2%)
Thrombosis 1 (2%) 5 (10%) 1 (2%)
Centrilobular, Degeneration, Hydropic 1 (2%)
Serosa, Fibrosis, Focal 1 (2%)
Sinusoid, Centrilobular, Dilatation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05044-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 09/06/94
Route: DERMAL,SOLUTION Time: 19:22:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/ML 25 MG/ML 50 MG/ML 100 MG/
ML
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mesentery (5) (4) (2)
Inflammation, Chronic 1 (20%) 1 (50%)
Inflammation, Subacute 1 (20%)
Necrosis 1 (20%) 1 (25%)
Pancreas (50) (49) (50) (50)
Ectopic Tissue 1 (2%)
Hypoplasia 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Acinus, Atrophy 4 (8%) 5 (10%) 3 (6%) 1 (2%)
Duct, Ectasia 1 (2%) 4 (8%)
Duct, Mineralization, Multifocal 1 (2%)
Salivary Glands (50) (49) (50) (50)
Inflammation, Multifocal, Subacute 2 (4%)
Necrosis, Coagulative 1 (2%)
Stomach, Forestomach (49) (50) (50) (50)
Acanthosis 6 (12%) 2 (4%)
Erosion 1 (2%)
Hyperkeratosis 2 (4%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Ulcer 6 (12%) 1 (2%) 3 (6%)
Stomach, Glandular (50) (49) (50) (50)
Hyperplasia 1 (2%)
Inflammation, Acute 4 (8%)
Ulcer 2 (4%)
Tooth (1) (1)
Gingiva, Abscess 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1) (2) (2)
Aorta, Bacterium 1 (50%) 2 (100%)
Aorta, Inflammation, Chronic Active 1 (100%) 1 (50%) 2 (100%)
Aorta, Mineralization 1 (100%)
Aorta, Thrombosis 1 (50%) 2 (100%)
Heart (50) (50) (50) (50)
Cardiomyopathy 1 (2%)
Atrium Left, Thrombosis 1 (2%)
Coronary Artery, Inflammation, Chronic 1 (2%) 1 (2%)
Myocardium, Inflammation, Chronic, Multifocal 3 (6%)
Myocardium, Inflammation, Focal, Subacute 1 (2%) 1 (2%)
Valve, Bacterium 1 (2%) 3 (6%) 1 (2%)
Valve, Inflammation, Subacute 1 (2%) 2 (4%)
Valve, Thrombosis 1 (2%) 3 (6%) 2 (4%)
Vein, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05044-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 09/06/94
Route: DERMAL,SOLUTION Time: 19:22:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/ML 25 MG/ML 50 MG/ML 100 MG/
ML
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (50) (50) (50)
Bilateral, Hyperplasia 1 (2%)
Bilateral, Capsule, Hyperplasia 1 (2%)
Capsule, Hyperplasia 49 (98%) 50 (100%) 47 (94%) 47 (94%)
Adrenal Gland, Cortex (50) (50) (50) (49)
Ectopic Tissue 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hyperplasia, Nodular 5 (10%) 3 (6%) 1 (2%) 2 (4%)
Inflammation, Chronic 1 (2%)
Inflammation, Subacute 2 (4%)
Adrenal Gland, Medulla (50) (49) (50) (48)
Hyperplasia, Nodular 3 (6%)
Islets, Pancreatic (49) (50) (49) (50)
Hyperplasia 2 (4%) 2 (4%) 2 (4%) 1 (2%)
Pituitary Gland (49) (48) (47) (45)
Pars Distalis, Hyperplasia, Nodular 4 (8%) 1 (2%) 4 (9%) 3 (7%)
Thyroid Gland (49) (49) (50) (50)
Cyst 1 (2%)
Follicle, Cyst 1 (2%)
Follicle, Hyperplasia, Nodular 14 (29%) 13 (27%) 5 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (1)
Duct, Dilatation 1 (100%)
Ovary (50) (49) (49) (50)
Atrophy 9 (18%) 11 (22%) 13 (27%) 8 (16%)
Congestion 1 (2%)
Cyst 20 (40%) 22 (45%) 16 (33%) 16 (32%)
Hemorrhage 2 (4%)
Hyperplasia, Tubular 1 (2%) 15 (31%) 17 (35%) 13 (26%)
Infiltration Cellular, Lymphocyte 1 (2%)
Necrosis, Acute 2 (4%)
Thrombosis 2 (4%) 1 (2%)
Bilateral, Atrophy 3 (6%) 32 (65%) 29 (59%) 39 (78%)
Bilateral, Cyst 4 (8%) 5 (10%) 10 (20%) 10 (20%)
Bilateral, Hyperplasia, Tubular 4 (8%) 20 (41%) 21 (43%) 21 (42%)
Periovarian Tissue, Inflammation, Subacute 1 (2%)
Uterus (50) (49) (49) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05044-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 09/06/94
Route: DERMAL,SOLUTION Time: 19:22:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/ML 25 MG/ML 50 MG/ML 100 MG/
ML
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 1 (2%)
Endometrium, Fibrosis 1 (2%)
Endometrium, Hyperplasia, Cystic 44 (88%) 36 (73%) 38 (78%) 21 (42%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Femoral, Myelofibrosis, Multifocal 1 (2%) 2 (4%) 2 (4%)
Femoral, Necrosis, Caseous 1 (2%)
Femoral, Thrombosis 1 (2%)
Sternal, Myelofibrosis, Multifocal 1 (2%) 12 (24%) 1 (2%)
Lymph Node (49) (49) (47) (50)
Mediastinal, Hyperplasia, Lymphoid 1 (2%)
Mediastinal, Infiltration Cellular,
Mononuclear Cell 1 (2%)
Mediastinal, Infiltration Cellular,
Polymorphonuclear 1 (2%)
Pancreatic, Infiltration Cellular,
Polymorphonuclear 1 (2%)
Renal, Infiltration Cellular,
Polymorphonuclear 1 (2%)
Lymph Node, Mandibular (48) (49) (47) (48)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%) 1 (2%)
Lymph Node, Mesenteric (6) (4) (6) (7)
Amyloid Deposition 1 (17%)
Hematopoietic Cell Proliferation 1 (17%) 1 (14%)
Infiltration Cellular, Polymorphonuclear 1 (25%) 2 (33%) 3 (43%)
Sinus, Ectasia 1 (17%) 2 (29%)
Spleen (50) (50) (50) (50)
Amyloid Deposition 2 (4%) 2 (4%)
Depletion Lymphoid 2 (4%) 4 (8%) 4 (8%) 1 (2%)
Hematopoietic Cell Proliferation 3 (6%) 7 (14%) 28 (56%) 30 (60%)
Hyperplasia, Lymphoid 1 (2%)
Thrombosis 1 (2%)
Thymus (42) (45) (33) (33)
Ectopic Thyroid 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (44) (41) (41) (39)
Cervical, Atypia Cytologic 1 (3%)
Inguinal, Hyperplasia, Cystic 4 (9%) 4 (10%) 3 (7%) 9 (23%)
Inguinal, Inflammation, Acute 1 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05044-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 09/06/94
Route: DERMAL,SOLUTION Time: 19:22:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/ML 25 MG/ML 50 MG/ML 100 MG/
ML
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Inguinal, Inflammation, Chronic 1 (2%) 1 (2%)
Skin (50) (50) (50) (50)
Abscess 1 (2%)
Acanthosis 4 (8%) 5 (10%) 4 (8%)
Edema 2 (4%)
Hyperkeratosis 1 (2%) 5 (10%) 2 (4%)
Inflammation, Chronic 3 (6%) 1 (2%)
Inflammation, Necrotizing 1 (2%) 6 (12%) 6 (12%)
Parasite Metazoan 1 (2%)
Back, Acanthosis 1 (2%) 5 (10%) 4 (8%)
Back, Hyperkeratosis 1 (2%) 4 (8%) 2 (4%)
Back, Inflammation, Necrotizing 5 (10%) 1 (2%)
Back, Parasite Metazoan 1 (2%)
Scapula, Abscess 2 (4%)
Scapula, Acanthosis 4 (8%) 31 (62%) 41 (82%) 36 (72%)
Scapula, Hyperkeratosis 1 (2%) 27 (54%) 29 (58%) 20 (40%)
Scapula, Inflammation, Chronic 2 (4%) 2 (4%)
Scapula, Inflammation, Necrotizing 2 (4%) 5 (10%) 15 (30%) 16 (32%)
Scapula, Parasite Metazoan 2 (4%)
Sebaceous Gland, Scapula, Hyperplasia 1 (2%)
Subcutaneous Tissue, Fibrosis 1 (2%) 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (2%)
Subcutaneous Tissue, Necrosis, Multifocal 1 (2%) 1 (2%)
Subcutaneous Tissue, Scapula, Necrosis,
Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (49) (50)
Humerus, Proliferation 1 (2%)
Skeletal Muscle (1) (2) (2)
Abdominal, Inflammation, Acute 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage, Multifocal 1 (2%)
Mineralization, Multifocal 28 (56%) 36 (72%) 24 (48%) 24 (48%)
Hypothalamus, Compression 3 (6%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05044-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 09/06/94
Route: DERMAL,SOLUTION Time: 19:22:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/ML 25 MG/ML 50 MG/ML 100 MG/
ML
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion, Diffuse 2 (4%) 1 (2%) 1 (2%)
Hemorrhage, Focal 1 (2%)
Hemorrhage, Multifocal 3 (6%) 1 (2%) 2 (4%) 2 (4%)
Inflammation, Focal, Suppurative 2 (4%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%) 1 (2%)
Artery, Inflammation, Subacute 1 (2%) 1 (2%)
Interstitium, Inflammation, Chronic 1 (2%)
Nose (50) (50) (50) (50)
Glands, Inflammation, Acute 1 (2%)
Nerve, Nares, Inflammation, Subacute 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (43) (46) (42) (45)
Hyperplasia 1 (2%)
Hyperplasia, Nodular 1 (2%)
Inflammation, Necrotizing 1 (2%)
Inflammation, Subacute 2 (5%) 3 (7%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Amyloid Deposition 1 (2%)
Inflammation, Multifocal, Subacute 1 (2%) 2 (4%)
Inflammation, Necrotizing 1 (2%) 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Renal Tubule, Bacterium 1 (2%) 1 (2%)
Renal Tubule, Casts Protein, Multifocal 1 (2%) 1 (2%)
Renal Tubule, Mineralization, Multifocal 1 (2%)
Renal Tubule, Necrosis, Coagulative,
Multifocal 1 (2%)
Urinary Bladder (49) (49) (48) (50)
Inflammation, Acute 2 (4%)
Wall, Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05044-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 09/06/94
Route: DERMAL,SOLUTION Time: 19:22:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/ML 25 MG/ML 50 MG/ML 100 MG/
ML
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund 3 4 27 30
Dead 6 11 17 20
Drowned 3 2
Survivors
Terminal Sacrifice 38 35 4
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (50) (50) (49)
Inflammation, Necrotizing 1 (2%)
Parasite Metazoan 1 (2%)
Intestine Large, Colon (50) (50) (50) (50)
Parasite Metazoan 1 (2%) 1 (2%) 1 (2%)
Intestine Large, Rectum (50) (48) (49) (48)
Parasite Metazoan 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Liver (50) (50) (50) (50)
Amyloid Deposition 1 (2%)
Basophilic Focus 2 (4%)
Cyst 3 (6%) 3 (6%) 4 (8%)
Cytomegaly, Multifocal 2 (4%)
Hematopoietic Cell Proliferation 1 (2%)
Inclusion Body Intracytoplasmic 1 (2%) 1 (2%) 2 (4%)
Inflammation, Chronic Active, Multifocal 1 (2%) 6 (12%) 7 (14%)
Inflammation, Diffuse, Subacute 1 (2%)
Necrosis, Coagulative, Focal 1 (2%) 1 (2%) 1 (2%)
Necrosis, Coagulative, Multifocal 1 (2%) 4 (8%) 5 (10%) 6 (12%)
Thrombosis 6 (12%) 2 (4%) 1 (2%) 2 (4%)
Sinusoid, Centrilobular, Dilatation 1 (2%)
Vein, Dilatation, Focal 1 (2%)
Mesentery (1) (1) (1)
Inflammation, Chronic 1 (100%)
Inflammation, Subacute 1 (100%)
Pancreas (49) (50) (50) (49)
Hyperplasia, Nodular 1 (2%)
Acinus, Atrophy 1 (2%) 2 (4%) 2 (4%) 2 (4%)
Duct, Ectasia 1 (2%)
Salivary Glands (50) (50) (50) (50)
Inflammation, Multifocal, Necrotizing 1 (2%)
Inflammation, Multifocal, Subacute 3 (6%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05044-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 09/06/94
Route: DERMAL,SOLUTION Time: 19:22:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/ML 25 MG/ML 50 MG/ML 100 MG/
ML
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Artery, Inflammation, Chronic 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Acanthosis 2 (4%) 1 (2%)
Hyperkeratosis 2 (4%) 1 (2%)
Ulcer 3 (6%)
Lamina Propria, Infiltration Cellular, Focal,
Histiocyte 1 (2%)
Stomach, Glandular (50) (50) (48) (50)
Hyperplasia 2 (4%)
Inflammation, Acute 3 (6%)
Inflammation, Necrotizing 1 (2%) 1 (2%)
Ulcer 4 (8%)
Serosa, Granuloma 1 (2%)
Tooth (4) (3) (1)
Peridontal Tissue, Incisor, Inflammation,
Chronic 2 (67%)
Peridontal Tissue, Molar, Abscess 1 (25%)
Peridontal Tissue, Molar, Inflammation,
Chronic 1 (33%) 1 (100%)
Pulp, Molar, Inflammation, Chronic 2 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1) (1)
Aorta, Bacterium 1 (100%) 1 (100%)
Aorta, Inflammation, Chronic Active 1 (100%) 1 (100%)
Aorta, Thrombosis 1 (100%) 1 (100%)
Renal Artery, Inflammation, Chronic 1 (100%)
Heart (50) (50) (50) (50)
Cardiomyopathy 1 (2%)
Dilatation 1 (2%)
Artery, Thrombosis 1 (2%)
Atrium Left, Dilatation 1 (2%)
Atrium Left, Thrombosis 1 (2%)
Coronary Artery, Inflammation, Chronic 1 (2%) 2 (4%)
Myocardium, Inflammation, Chronic, Focal 1 (2%) 3 (6%)
Myocardium, Inflammation, Chronic, Multifocal 1 (2%)
Myocardium, Inflammation, Focal, Subacute 1 (2%) 1 (2%)
Myocardium, Mineralization, Multifocal 1 (2%) 1 (2%)
Pericardium, Ectopic Thyroid 1 (2%)
Valve, Bacterium 2 (4%) 1 (2%)
Valve, Inflammation, Subacute 1 (2%) 2 (4%) 1 (2%)
Valve, Thrombosis 1 (2%) 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05044-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 09/06/94
Route: DERMAL,SOLUTION Time: 19:22:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/ML 25 MG/ML 50 MG/ML 100 MG/
ML
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (50) (49) (50)
Capsule, Hyperplasia 44 (88%) 42 (84%) 38 (78%) 44 (88%)
Adrenal Gland, Cortex (50) (49) (49) (50)
Hyperplasia, Focal, Nodular 1 (2%)
Hyperplasia, Nodular 27 (54%) 30 (61%) 5 (10%) 5 (10%)
Necrosis, Liquifactive 1 (2%)
Adrenal Gland, Medulla (50) (49) (48) (47)
Hyperplasia 1 (2%)
Necrosis, Liquifactive 1 (2%)
Islets, Pancreatic (48) (50) (47) (48)
Cytoplasmic Alteration 1 (2%)
Hyperplasia 22 (46%) 5 (10%) 3 (6%) 4 (8%)
Pituitary Gland (43) (47) (42) (38)
Pars Distalis, Hyperplasia 1 (2%)
Pars Distalis, Hyperplasia, Nodular 1 (2%) 1 (2%)
Thyroid Gland (49) (50) (49) (48)
Hyperplasia, Nodular 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Follicle, Hyperplasia, Nodular 12 (24%) 9 (18%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (49)
Granuloma Sperm 1 (2%)
Inflammation, Subacute 6 (12%) 13 (27%)
Preputial Gland (10) (4) (6) (1)
Abscess 6 (60%) 3 (75%) 2 (33%)
Inflammation, Chronic 1 (10%) 1 (25%) 1 (17%)
Duct, Dilatation 4 (40%) 1 (25%) 5 (83%) 1 (100%)
Prostate (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%) 1 (2%) 5 (10%) 6 (12%)
Seminal Vesicle (1)
Dilatation 1 (100%)
Testes (50) (50) (50) (50)
Infarct 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Seminiferous Tubule, Atrophy 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05044-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 09/06/94
Route: DERMAL,SOLUTION Time: 19:22:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/ML 25 MG/ML 50 MG/ML 100 MG/
ML
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (1) (1)
Polychromasia 1 (100%)
Bone Marrow (49) (50) (49) (49)
Femoral, Necrosis, Caseous 1 (2%)
Femoral, Thrombosis 1 (2%)
Myeloid Cell, Hyperplasia 1 (2%)
Lymph Node (49) (49) (45) (46)
Hyperplasia, Lymphoid 1 (2%)
Bronchial, Infiltration Cellular,
Polymorphonuclear 1 (2%)
Deep Cervical, Infiltration Cellular,
Polymorphonuclear 1 (2%)
Mediastinal, Infiltration Cellular,
Polymorphonuclear 2 (4%) 2 (4%)
Mediastinal, Infiltration Cellular,
Histiocyte 2 (4%)
Renal, Hyperplasia, Plasma Cell 1 (2%)
Renal, Infiltration Cellular,
Polymorphonuclear 1 (2%)
Lymph Node, Mandibular (48) (46) (43) (44)
Hematopoietic Cell Proliferation 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (2%) 3 (7%) 5 (11%)
Infiltration Cellular, Histiocyte 1 (2%)
Lymph Node, Mesenteric (5) (8) (13) (9)
Hematopoietic Cell Proliferation 1 (20%) 1 (13%) 1 (8%) 1 (11%)
Infiltration Cellular, Polymorphonuclear 1 (20%) 1 (13%) 10 (77%) 6 (67%)
Sinus, Ectasia 2 (40%) 1 (13%) 4 (31%) 3 (33%)
Spleen (49) (50) (50) (50)
Amyloid Deposition 1 (2%)
Depletion Lymphoid 4 (8%) 2 (4%) 8 (16%) 2 (4%)
Fibrosis 1 (2%)
Fibrosis, Focal 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 7 (14%) 31 (62%) 39 (78%)
Necrosis, Coagulative 1 (2%)
Thrombosis 1 (2%)
Subcapsular, Infiltration Cellular,
Multifocal, Histiocyte 1 (2%)
Thymus (40) (42) (27) (27)
Ectopic Parathyroid Gland 1 (2%)
Necrosis 1 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05044-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 09/06/94
Route: DERMAL,SOLUTION Time: 19:22:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/ML 25 MG/ML 50 MG/ML 100 MG/
ML
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Abscess 1 (2%) 1 (2%)
Acanthosis 5 (10%) 6 (12%) 5 (10%)
Cyst Epithelial Inclusion 1 (2%)
Edema 1 (2%) 1 (2%)
Hyperkeratosis 1 (2%) 2 (4%)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Necrotizing 6 (12%) 1 (2%)
Back, Acanthosis 6 (12%) 6 (12%) 2 (4%)
Back, Hyperkeratosis 1 (2%) 4 (8%) 4 (8%)
Back, Inflammation, Necrotizing 1 (2%)
Back, Parasite Metazoan 1 (2%)
Lymphatic, Dilatation 1 (2%)
Scapula, Acanthosis 1 (2%) 35 (70%) 38 (76%) 35 (70%)
Scapula, Hyperkeratosis 1 (2%) 12 (24%) 14 (28%) 21 (42%)
Scapula, Inflammation, Chronic 1 (2%)
Scapula, Inflammation, Chronic Active 1 (2%)
Scapula, Inflammation, Necrotizing 1 (2%) 4 (8%) 12 (24%) 15 (30%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (49) (50)
Artery, Femur, Thrombosis 1 (2%)
Cranium, Proliferation 1 (2%)
Tibia, Inflammation, Acute 1 (2%)
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NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Autolysis 1 (2%)
Hemorrhage, Multifocal 1 (2%) 1 (2%)
Mineralization, Multifocal 21 (42%) 30 (60%) 25 (50%) 22 (44%)
Hypothalamus, Compression 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion, Diffuse 3 (6%)
Hemorrhage, Focal 2 (4%) 2 (4%) 3 (6%)
Hemorrhage, Multifocal 2 (4%) 2 (4%) 1 (2%)
Inflammation, Focal, Suppurative 1 (2%)
Thrombosis 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05044-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 09/06/94
Route: DERMAL,SOLUTION Time: 19:22:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/ML 25 MG/ML 50 MG/ML 100 MG/
ML
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Alveolar Epithelium, Hyperplasia 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%) 1 (2%)
Bronchiole, Edema, Diffuse 1 (2%)
Interstitium, Inflammation, Chronic 2 (4%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (39) (42) (48) (42)
Hyperplasia, Nodular 2 (5%) 1 (2%) 1 (2%)
Inflammation, Chronic, Focal 1 (3%) 1 (2%)
Inflammation, Subacute 4 (8%) 5 (12%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Ectopic Tissue 1 (2%)
Hemorrhage, Multifocal 1 (2%)
Hydronephrosis 1 (2%)
Infarct 2 (4%) 1 (2%)
Inflammation, Multifocal, Subacute 2 (4%) 3 (6%)
Inflammation, Necrotizing 1 (2%) 1 (2%) 1 (2%)
Fat, Infiltration Cellular, Focal, Histiocyte 1 (2%)
Glomerulus, Inflammation, Proliferative 1 (2%)
Renal Tubule, Bacterium 1 (2%) 1 (2%)
Renal Tubule, Casts Protein, Multifocal 1 (2%)
Renal Tubule, Cyst 1 (2%) 1 (2%)
Urinary Bladder (50) (48) (49) (48)
Ectasia 1 (2%)
Thrombosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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