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https://ntp.niehs.nih.gov/go/1277

TDMS Study 05044-02 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE


NTP Experiment-Test: 05044-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/06/94
Route: DERMAL,SOLUTION                                                                                            Time: 19:22:53




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  106-87-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05044-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 19:22:53  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/ML      25 MG/ML     50 MG/ML     100 MG/                                   
                                                                                          ML                                        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                           3            3            8           29                                     
    Dead                                               3            7            7            9                                     
    Accident                                           1                                                                            
    Drowned                                            1            1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           31           14           10                                     
    Moribund                                           7            7           15            2                                     
    Dead                                               4            1            6                                                  
    Accidently Killed                                  1                                                                            
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (48)         (49)         (48)         (49)                                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Amyloid Deposition                               1 (2%)                                                                       
      Inflammation, Necrotizing                                                               1 (2%)                                
   Intestine Small, Duodenum                          (49)         (50)         (50)         (50)                                   
      Inflammation, Necrotizing                                                               1 (2%)                                
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Amyloid Deposition                               1 (2%)                                                                       
      Necrosis, Coagulative                            1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)                                   
      Amyloid Deposition                                                         1 (2%)       1 (2%)                                
      Angiectasis                                      1 (2%)                    1 (2%)                                             
      Basophilic Focus                                              1 (2%)                    1 (2%)                                
      Cyst                                             1 (2%)                    2 (4%)                                             
      Degeneration, Cystic                             2 (4%)                                                                       
      Erythrophagocytosis                              1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                    3 (6%)       2 (4%)                                
      Hepatodiaphragmatic Nodule                       1 (2%)                                                                       
      Inclusion Body Intracytoplasmic                  2 (4%)       2 (4%)       2 (4%)       1 (2%)                                
      Inflammation, Chronic Active, Multifocal                                   6 (12%)      5 (10%)                               
      Necrosis, Coagulative, Multifocal                2 (4%)       1 (2%)       4 (8%)       8 (16%)                               
      Necrosis, Caseous, Multifocal                                              1 (2%)                                             
      Thrombosis                                                    1 (2%)       5 (10%)      1 (2%)                                
      Centrilobular, Degeneration, Hydropic                         1 (2%)                                                          
      Serosa, Fibrosis, Focal                          1 (2%)                                                                       
      Sinusoid, Centrilobular, Dilatation                                        1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05044-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 19:22:53  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/ML      25 MG/ML     50 MG/ML     100 MG/                                   
                                                                                          ML                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (5)          (4)          (2)                                                 
      Inflammation, Chronic                            1 (20%)                   1 (50%)                                            
      Inflammation, Subacute                           1 (20%)                                                                      
      Necrosis                                         1 (20%)      1 (25%)                                                         
   Pancreas                                           (50)         (49)         (50)         (50)                                   
      Ectopic Tissue                                                             1 (2%)                                             
      Hypoplasia                                                                              1 (2%)                                
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Inflammation, Granulomatous                                                1 (2%)                                             
      Acinus, Atrophy                                  4 (8%)       5 (10%)      3 (6%)       1 (2%)                                
      Duct, Ectasia                                    1 (2%)       4 (8%)                                                          
      Duct, Mineralization, Multifocal                              1 (2%)                                                          
   Salivary Glands                                    (50)         (49)         (50)         (50)                                   
      Inflammation, Multifocal, Subacute                                         2 (4%)                                             
      Necrosis, Coagulative                                                                   1 (2%)                                
   Stomach, Forestomach                               (49)         (50)         (50)         (50)                                   
      Acanthosis                                       6 (12%)                                2 (4%)                                
      Erosion                                          1 (2%)                                                                       
      Hyperkeratosis                                   2 (4%)                                                                       
      Inflammation, Chronic Active                     1 (2%)                                 1 (2%)                                
      Ulcer                                            6 (12%)                   1 (2%)       3 (6%)                                
   Stomach, Glandular                                 (50)         (49)         (50)         (50)                                   
      Hyperplasia                                                                             1 (2%)                                
      Inflammation, Acute                                                                     4 (8%)                                
      Ulcer                                            2 (4%)                                                                       
   Tooth                                                           (1)                       (1)                                    
      Gingiva, Abscess                                                                        1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)          (1)          (2)          (2)                                    
      Aorta, Bacterium                                                           1 (50%)      2 (100%)                              
      Aorta, Inflammation, Chronic Active              1 (100%)                  1 (50%)      2 (100%)                              
      Aorta, Mineralization                                         1 (100%)                                                        
      Aorta, Thrombosis                                                          1 (50%)      2 (100%)                              
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                                1 (2%)                                                          
      Atrium Left, Thrombosis                                       1 (2%)                                                          
      Coronary Artery, Inflammation, Chronic                        1 (2%)       1 (2%)                                             
      Myocardium, Inflammation, Chronic, Multifocal                              3 (6%)                                             
      Myocardium, Inflammation, Focal, Subacute                                  1 (2%)       1 (2%)                                
      Valve, Bacterium                                 1 (2%)       3 (6%)       1 (2%)                                             
      Valve, Inflammation, Subacute                    1 (2%)       2 (4%)                                                          
      Valve, Thrombosis                                1 (2%)       3 (6%)       2 (4%)                                             
      Vein, Thrombosis                                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05044-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 19:22:53  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/ML      25 MG/ML     50 MG/ML     100 MG/                                   
                                                                                          ML                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (50)         (50)         (50)                                   
      Bilateral, Hyperplasia                                                                  1 (2%)                                
      Bilateral, Capsule, Hyperplasia                                            1 (2%)                                             
      Capsule, Hyperplasia                            49 (98%)     50 (100%)    47 (94%)     47 (94%)                               
   Adrenal Gland, Cortex                              (50)         (50)         (50)         (49)                                   
      Ectopic Tissue                                                                          1 (2%)                                
      Hematopoietic Cell Proliferation                                           1 (2%)       1 (2%)                                
      Hyperplasia, Nodular                             5 (10%)      3 (6%)       1 (2%)       2 (4%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
      Inflammation, Subacute                                                     2 (4%)                                             
   Adrenal Gland, Medulla                             (50)         (49)         (50)         (48)                                   
      Hyperplasia, Nodular                             3 (6%)                                                                       
   Islets, Pancreatic                                 (49)         (50)         (49)         (50)                                   
      Hyperplasia                                      2 (4%)       2 (4%)       2 (4%)       1 (2%)                                
   Pituitary Gland                                    (49)         (48)         (47)         (45)                                   
      Pars Distalis, Hyperplasia, Nodular              4 (8%)       1 (2%)       4 (9%)       3 (7%)                                
   Thyroid Gland                                      (49)         (49)         (50)         (50)                                   
      Cyst                                                                       1 (2%)                                             
      Follicle, Cyst                                   1 (2%)                                                                       
      Follicle, Hyperplasia, Nodular                  14 (29%)     13 (27%)      5 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (1)                                                                           
      Duct, Dilatation                                 1 (100%)                                                                     
   Ovary                                              (50)         (49)         (49)         (50)                                   
      Atrophy                                          9 (18%)     11 (22%)     13 (27%)      8 (16%)                               
      Congestion                                                                 1 (2%)                                             
      Cyst                                            20 (40%)     22 (45%)     16 (33%)     16 (32%)                               
      Hemorrhage                                                                              2 (4%)                                
      Hyperplasia, Tubular                             1 (2%)      15 (31%)     17 (35%)     13 (26%)                               
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Necrosis, Acute                                               2 (4%)                                                          
      Thrombosis                                                    2 (4%)       1 (2%)                                             
      Bilateral, Atrophy                               3 (6%)      32 (65%)     29 (59%)     39 (78%)                               
      Bilateral, Cyst                                  4 (8%)       5 (10%)     10 (20%)     10 (20%)                               
      Bilateral, Hyperplasia, Tubular                  4 (8%)      20 (41%)     21 (43%)     21 (42%)                               
      Periovarian Tissue, Inflammation, Subacute                                              1 (2%)                                
   Uterus                                             (50)         (49)         (49)         (50)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05044-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 19:22:53  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/ML      25 MG/ML     50 MG/ML     100 MG/                                   
                                                                                          ML                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Inflammation, Suppurative                                                               1 (2%)                                
      Endometrium, Fibrosis                                                                   1 (2%)                                
      Endometrium, Hyperplasia, Cystic                44 (88%)     36 (73%)     38 (78%)     21 (42%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Femoral, Myelofibrosis, Multifocal               1 (2%)       2 (4%)                    2 (4%)                                
      Femoral, Necrosis, Caseous                                                              1 (2%)                                
      Femoral, Thrombosis                                           1 (2%)                                                          
      Sternal, Myelofibrosis, Multifocal               1 (2%)      12 (24%)                   1 (2%)                                
   Lymph Node                                         (49)         (49)         (47)         (50)                                   
      Mediastinal, Hyperplasia, Lymphoid                                         1 (2%)                                             
      Mediastinal, Infiltration Cellular,                                                                                           
          Mononuclear Cell                                                       1 (2%)                                             
      Mediastinal, Infiltration Cellular,                                                                                           
          Polymorphonuclear                                                      1 (2%)                                             
      Pancreatic, Infiltration Cellular,                                                                                            
          Polymorphonuclear                                                      1 (2%)                                             
      Renal, Infiltration Cellular,                                                                                                 
          Polymorphonuclear                                                                   1 (2%)                                
   Lymph Node, Mandibular                             (48)         (49)         (47)         (48)                                   
      Infiltration Cellular, Polymorphonuclear                                                1 (2%)                                
      Infiltration Cellular, Histiocyte                1 (2%)                    1 (2%)                                             
   Lymph Node, Mesenteric                             (6)          (4)          (6)          (7)                                    
      Amyloid Deposition                               1 (17%)                                                                      
      Hematopoietic Cell Proliferation                                           1 (17%)      1 (14%)                               
      Infiltration Cellular, Polymorphonuclear                      1 (25%)      2 (33%)      3 (43%)                               
      Sinus, Ectasia                                   1 (17%)                                2 (29%)                               
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Amyloid Deposition                                                         2 (4%)       2 (4%)                                
      Depletion Lymphoid                               2 (4%)       4 (8%)       4 (8%)       1 (2%)                                
      Hematopoietic Cell Proliferation                 3 (6%)       7 (14%)     28 (56%)     30 (60%)                               
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Thrombosis                                                    1 (2%)                                                          
   Thymus                                             (42)         (45)         (33)         (33)                                   
      Ectopic Thyroid                                                            1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (44)         (41)         (41)         (39)                                   
      Cervical, Atypia Cytologic                                                              1 (3%)                                
      Inguinal, Hyperplasia, Cystic                    4 (9%)       4 (10%)      3 (7%)       9 (23%)                               
      Inguinal, Inflammation, Acute                                                           1 (3%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05044-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 19:22:53  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/ML      25 MG/ML     50 MG/ML     100 MG/                                   
                                                                                          ML                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Inguinal, Inflammation, Chronic                  1 (2%)                    1 (2%)                                             
   Skin                                               (50)         (50)         (50)         (50)                                   
      Abscess                                                                                 1 (2%)                                
      Acanthosis                                       4 (8%)                    5 (10%)      4 (8%)                                
      Edema                                            2 (4%)                                                                       
      Hyperkeratosis                                   1 (2%)                    5 (10%)      2 (4%)                                
      Inflammation, Chronic                                                      3 (6%)       1 (2%)                                
      Inflammation, Necrotizing                        1 (2%)                    6 (12%)      6 (12%)                               
      Parasite Metazoan                                1 (2%)                                                                       
      Back, Acanthosis                                 1 (2%)                    5 (10%)      4 (8%)                                
      Back, Hyperkeratosis                                          1 (2%)       4 (8%)       2 (4%)                                
      Back, Inflammation, Necrotizing                                            5 (10%)      1 (2%)                                
      Back, Parasite Metazoan                          1 (2%)                                                                       
      Scapula, Abscess                                                                        2 (4%)                                
      Scapula, Acanthosis                              4 (8%)      31 (62%)     41 (82%)     36 (72%)                               
      Scapula, Hyperkeratosis                          1 (2%)      27 (54%)     29 (58%)     20 (40%)                               
      Scapula, Inflammation, Chronic                   2 (4%)       2 (4%)                                                          
      Scapula, Inflammation, Necrotizing               2 (4%)       5 (10%)     15 (30%)     16 (32%)                               
      Scapula, Parasite Metazoan                       2 (4%)                                                                       
      Sebaceous Gland, Scapula, Hyperplasia                         1 (2%)                                                          
      Subcutaneous Tissue, Fibrosis                    1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                                                 1 (2%)                                             
      Subcutaneous Tissue, Necrosis, Multifocal        1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Scapula, Necrosis,                                                                                       
          Multifocal                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)         (50)                                   
      Humerus, Proliferation                                                     1 (2%)                                             
   Skeletal Muscle                                    (1)                       (2)          (2)                                    
      Abdominal, Inflammation, Acute                   1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hemorrhage, Multifocal                           1 (2%)                                                                       
      Mineralization, Multifocal                      28 (56%)     36 (72%)     24 (48%)     24 (48%)                               
      Hypothalamus, Compression                        3 (6%)       2 (4%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05044-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 19:22:53  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/ML      25 MG/ML     50 MG/ML     100 MG/                                   
                                                                                          ML                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion, Diffuse                              2 (4%)       1 (2%)       1 (2%)                                             
      Hemorrhage, Focal                                                          1 (2%)                                             
      Hemorrhage, Multifocal                           3 (6%)       1 (2%)       2 (4%)       2 (4%)                                
      Inflammation, Focal, Suppurative                                                        2 (4%)                                
      Alveolar Epithelium, Hyperplasia                 1 (2%)       1 (2%)                    1 (2%)                                
      Alveolus, Infiltration Cellular, Histiocyte      1 (2%)                                 1 (2%)                                
      Artery, Inflammation, Subacute                                1 (2%)                    1 (2%)                                
      Interstitium, Inflammation, Chronic              1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)         (50)                                   
      Glands, Inflammation, Acute                                                             1 (2%)                                
      Nerve, Nares, Inflammation, Subacute                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (43)         (46)         (42)         (45)                                   
      Hyperplasia                                      1 (2%)                                                                       
      Hyperplasia, Nodular                                                                    1 (2%)                                
      Inflammation, Necrotizing                                                               1 (2%)                                
      Inflammation, Subacute                                                     2 (5%)       3 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Amyloid Deposition                                                         1 (2%)                                             
      Inflammation, Multifocal, Subacute                                         1 (2%)       2 (4%)                                
      Inflammation, Necrotizing                        1 (2%)                    1 (2%)       1 (2%)                                
      Thrombosis                                       1 (2%)                                                                       
      Renal Tubule, Bacterium                                                    1 (2%)       1 (2%)                                
      Renal Tubule, Casts Protein, Multifocal                                    1 (2%)       1 (2%)                                
      Renal Tubule, Mineralization, Multifocal                                                1 (2%)                                
      Renal Tubule, Necrosis, Coagulative,                                                                                          
          Multifocal                                                                          1 (2%)                                
   Urinary Bladder                                    (49)         (49)         (48)         (50)                                   
      Inflammation, Acute                                                                     2 (4%)                                
      Wall, Inflammation, Chronic                                                1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05044-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 19:22:53  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/ML      25 MG/ML     50 MG/ML     100 MG/                                   
                                                                                          ML                                        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                           3            4           27           30                                     
    Dead                                               6           11           17           20                                     
    Drowned                                            3                         2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           35            4                                                  
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (50)         (50)         (49)                                   
      Inflammation, Necrotizing                                                               1 (2%)                                
      Parasite Metazoan                                             1 (2%)                                                          
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Parasite Metazoan                                1 (2%)       1 (2%)                    1 (2%)                                
   Intestine Large, Rectum                            (50)         (48)         (49)         (48)                                   
      Parasite Metazoan                                2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Amyloid Deposition                                                         1 (2%)                                             
      Basophilic Focus                                                           2 (4%)                                             
      Cyst                                             3 (6%)       3 (6%)       4 (8%)                                             
      Cytomegaly, Multifocal                           2 (4%)                                                                       
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Inclusion Body Intracytoplasmic                  1 (2%)       1 (2%)       2 (4%)                                             
      Inflammation, Chronic Active, Multifocal         1 (2%)                    6 (12%)      7 (14%)                               
      Inflammation, Diffuse, Subacute                                                         1 (2%)                                
      Necrosis, Coagulative, Focal                                  1 (2%)       1 (2%)       1 (2%)                                
      Necrosis, Coagulative, Multifocal                1 (2%)       4 (8%)       5 (10%)      6 (12%)                               
      Thrombosis                                       6 (12%)      2 (4%)       1 (2%)       2 (4%)                                
      Sinusoid, Centrilobular, Dilatation                                                     1 (2%)                                
      Vein, Dilatation, Focal                                       1 (2%)                                                          
   Mesentery                                          (1)          (1)                       (1)                                    
      Inflammation, Chronic                            1 (100%)                                                                     
      Inflammation, Subacute                                                                  1 (100%)                              
   Pancreas                                           (49)         (50)         (50)         (49)                                   
      Hyperplasia, Nodular                             1 (2%)                                                                       
      Acinus, Atrophy                                  1 (2%)       2 (4%)       2 (4%)       2 (4%)                                
      Duct, Ectasia                                                                           1 (2%)                                
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Inflammation, Multifocal, Necrotizing                                                   1 (2%)                                
      Inflammation, Multifocal, Subacute                                         3 (6%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05044-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 19:22:53  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/ML      25 MG/ML     50 MG/ML     100 MG/                                   
                                                                                          ML                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Artery, Inflammation, Chronic                    1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Acanthosis                                       2 (4%)                                 1 (2%)                                
      Hyperkeratosis                                   2 (4%)                                 1 (2%)                                
      Ulcer                                            3 (6%)                                                                       
      Lamina Propria, Infiltration Cellular, Focal,                                                                                 
           Histiocyte                                  1 (2%)                                                                       
   Stomach, Glandular                                 (50)         (50)         (48)         (50)                                   
      Hyperplasia                                                                             2 (4%)                                
      Inflammation, Acute                                                                     3 (6%)                                
      Inflammation, Necrotizing                        1 (2%)                                 1 (2%)                                
      Ulcer                                                                                   4 (8%)                                
      Serosa, Granuloma                                1 (2%)                                                                       
   Tooth                                              (4)          (3)                       (1)                                    
      Peridontal Tissue, Incisor, Inflammation,                                                                                     
           Chronic                                                  2 (67%)                                                         
      Peridontal Tissue, Molar, Abscess                1 (25%)                                                                      
      Peridontal Tissue, Molar, Inflammation,                                                                                       
          Chronic                                                   1 (33%)                   1 (100%)                              
      Pulp, Molar, Inflammation, Chronic               2 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (1)          (1)          (1)                                    
      Aorta, Bacterium                                                           1 (100%)     1 (100%)                              
      Aorta, Inflammation, Chronic Active                                        1 (100%)     1 (100%)                              
      Aorta, Thrombosis                                                          1 (100%)     1 (100%)                              
      Renal Artery, Inflammation, Chronic                           1 (100%)                                                        
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                                                          1 (2%)                                
      Dilatation                                                                              1 (2%)                                
      Artery, Thrombosis                                            1 (2%)                                                          
      Atrium Left, Dilatation                                       1 (2%)                                                          
      Atrium Left, Thrombosis                                       1 (2%)                                                          
      Coronary Artery, Inflammation, Chronic           1 (2%)       2 (4%)                                                          
      Myocardium, Inflammation, Chronic, Focal         1 (2%)                                 3 (6%)                                
      Myocardium, Inflammation, Chronic, Multifocal                 1 (2%)                                                          
      Myocardium, Inflammation, Focal, Subacute                     1 (2%)                    1 (2%)                                
      Myocardium, Mineralization, Multifocal           1 (2%)                    1 (2%)                                             
      Pericardium, Ectopic Thyroid                     1 (2%)                                                                       
      Valve, Bacterium                                                           2 (4%)       1 (2%)                                
      Valve, Inflammation, Subacute                                 1 (2%)       2 (4%)       1 (2%)                                
      Valve, Thrombosis                                             1 (2%)       3 (6%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05044-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 19:22:53  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/ML      25 MG/ML     50 MG/ML     100 MG/                                   
                                                                                          ML                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (50)         (49)         (50)                                   
      Capsule, Hyperplasia                            44 (88%)     42 (84%)     38 (78%)     44 (88%)                               
   Adrenal Gland, Cortex                              (50)         (49)         (49)         (50)                                   
      Hyperplasia, Focal, Nodular                                                1 (2%)                                             
      Hyperplasia, Nodular                            27 (54%)     30 (61%)      5 (10%)      5 (10%)                               
      Necrosis, Liquifactive                                                     1 (2%)                                             
   Adrenal Gland, Medulla                             (50)         (49)         (48)         (47)                                   
      Hyperplasia                                      1 (2%)                                                                       
      Necrosis, Liquifactive                                                     1 (2%)                                             
   Islets, Pancreatic                                 (48)         (50)         (47)         (48)                                   
      Cytoplasmic Alteration                                        1 (2%)                                                          
      Hyperplasia                                     22 (46%)      5 (10%)      3 (6%)       4 (8%)                                
   Pituitary Gland                                    (43)         (47)         (42)         (38)                                   
      Pars Distalis, Hyperplasia                                    1 (2%)                                                          
      Pars Distalis, Hyperplasia, Nodular              1 (2%)       1 (2%)                                                          
   Thyroid Gland                                      (49)         (50)         (49)         (48)                                   
      Hyperplasia, Nodular                                          1 (2%)       1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
      Follicle, Hyperplasia, Nodular                  12 (24%)      9 (18%)      2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (49)                                   
      Granuloma Sperm                                               1 (2%)                                                          
      Inflammation, Subacute                                                     6 (12%)     13 (27%)                               
   Preputial Gland                                    (10)         (4)          (6)          (1)                                    
      Abscess                                          6 (60%)      3 (75%)      2 (33%)                                            
      Inflammation, Chronic                            1 (10%)      1 (25%)      1 (17%)                                            
      Duct, Dilatation                                 4 (40%)      1 (25%)      5 (83%)      1 (100%)                              
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                     1 (2%)       1 (2%)       5 (10%)      6 (12%)                               
   Seminal Vesicle                                    (1)                                                                           
      Dilatation                                       1 (100%)                                                                     
   Testes                                             (50)         (50)         (50)         (50)                                   
      Infarct                                          1 (2%)                                                                       
      Inflammation, Chronic, Focal                                  1 (2%)                                                          
      Seminiferous Tubule, Atrophy                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05044-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 19:22:53  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/ML      25 MG/ML     50 MG/ML     100 MG/                                   
                                                                                          ML                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)                                    (1)                                    
      Polychromasia                                    1 (100%)                                                                     
   Bone Marrow                                        (49)         (50)         (49)         (49)                                   
      Femoral, Necrosis, Caseous                                                              1 (2%)                                
      Femoral, Thrombosis                              1 (2%)                                                                       
      Myeloid Cell, Hyperplasia                                                               1 (2%)                                
   Lymph Node                                         (49)         (49)         (45)         (46)                                   
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Bronchial, Infiltration Cellular,                                                                                             
          Polymorphonuclear                                                      1 (2%)                                             
      Deep Cervical, Infiltration Cellular,                                                                                         
          Polymorphonuclear                                                                   1 (2%)                                
      Mediastinal, Infiltration Cellular,                                                                                           
          Polymorphonuclear                                                      2 (4%)       2 (4%)                                
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                                          2 (4%)                                
      Renal, Hyperplasia, Plasma Cell                                            1 (2%)                                             
      Renal, Infiltration Cellular,                                                                                                 
          Polymorphonuclear                                                      1 (2%)                                             
   Lymph Node, Mandibular                             (48)         (46)         (43)         (44)                                   
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Infiltration Cellular, Polymorphonuclear         1 (2%)                    3 (7%)       5 (11%)                               
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
   Lymph Node, Mesenteric                             (5)          (8)          (13)         (9)                                    
      Hematopoietic Cell Proliferation                 1 (20%)      1 (13%)      1 (8%)       1 (11%)                               
      Infiltration Cellular, Polymorphonuclear         1 (20%)      1 (13%)     10 (77%)      6 (67%)                               
      Sinus, Ectasia                                   2 (40%)      1 (13%)      4 (31%)      3 (33%)                               
   Spleen                                             (49)         (50)         (50)         (50)                                   
      Amyloid Deposition                                            1 (2%)                                                          
      Depletion Lymphoid                               4 (8%)       2 (4%)       8 (16%)      2 (4%)                                
      Fibrosis                                                                   1 (2%)                                             
      Fibrosis, Focal                                  1 (2%)       1 (2%)                                                          
      Hematopoietic Cell Proliferation                 2 (4%)       7 (14%)     31 (62%)     39 (78%)                               
      Necrosis, Coagulative                                                      1 (2%)                                             
      Thrombosis                                       1 (2%)                                                                       
      Subcapsular, Infiltration Cellular,                                                                                           
          Multifocal, Histiocyte                       1 (2%)                                                                       
   Thymus                                             (40)         (42)         (27)         (27)                                   
      Ectopic Parathyroid Gland                                     1 (2%)                                                          
      Necrosis                                                                                1 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05044-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 19:22:53  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/ML      25 MG/ML     50 MG/ML     100 MG/                                   
                                                                                          ML                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Abscess                                          1 (2%)                    1 (2%)                                             
      Acanthosis                                                    5 (10%)      6 (12%)      5 (10%)                               
      Cyst Epithelial Inclusion                                                               1 (2%)                                
      Edema                                                         1 (2%)       1 (2%)                                             
      Hyperkeratosis                                                1 (2%)       2 (4%)                                             
      Inflammation, Acute                                                        1 (2%)       1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                 1 (2%)                                
      Inflammation, Necrotizing                                                  6 (12%)      1 (2%)                                
      Back, Acanthosis                                              6 (12%)      6 (12%)      2 (4%)                                
      Back, Hyperkeratosis                                          1 (2%)       4 (8%)       4 (8%)                                
      Back, Inflammation, Necrotizing                                                         1 (2%)                                
      Back, Parasite Metazoan                          1 (2%)                                                                       
      Lymphatic, Dilatation                                                                   1 (2%)                                
      Scapula, Acanthosis                              1 (2%)      35 (70%)     38 (76%)     35 (70%)                               
      Scapula, Hyperkeratosis                          1 (2%)      12 (24%)     14 (28%)     21 (42%)                               
      Scapula, Inflammation, Chronic                                1 (2%)                                                          
      Scapula, Inflammation, Chronic Active                                      1 (2%)                                             
      Scapula, Inflammation, Necrotizing               1 (2%)       4 (8%)      12 (24%)     15 (30%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)         (50)                                   
      Artery, Femur, Thrombosis                                                               1 (2%)                                
      Cranium, Proliferation                           1 (2%)                                                                       
      Tibia, Inflammation, Acute                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Autolysis                                                                               1 (2%)                                
      Hemorrhage, Multifocal                           1 (2%)                                 1 (2%)                                
      Mineralization, Multifocal                      21 (42%)     30 (60%)     25 (50%)     22 (44%)                               
      Hypothalamus, Compression                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion, Diffuse                              3 (6%)                                                                       
      Hemorrhage, Focal                                2 (4%)                    2 (4%)       3 (6%)                                
      Hemorrhage, Multifocal                           2 (4%)                    2 (4%)       1 (2%)                                
      Inflammation, Focal, Suppurative                 1 (2%)                                                                       
      Thrombosis                                                                 1 (2%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05044-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  4-VINYL-1-CYCLOHEXENE DIEPOXIDE                              Date: 09/06/94  
Route: DERMAL,SOLUTION                                                                                            Time: 19:22:53  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/ML      25 MG/ML     50 MG/ML     100 MG/                                   
                                                                                          ML                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolar Epithelium, Hyperplasia                                                        1 (2%)                                
      Alveolus, Infiltration Cellular, Histiocyte                   1 (2%)                    1 (2%)                                
      Bronchiole, Edema, Diffuse                       1 (2%)                                                                       
      Interstitium, Inflammation, Chronic                           2 (4%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (39)         (42)         (48)         (42)                                   
      Hyperplasia, Nodular                             2 (5%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic, Focal                     1 (3%)                                 1 (2%)                                
      Inflammation, Subacute                                                     4 (8%)       5 (12%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Ectopic Tissue                                   1 (2%)                                                                       
      Hemorrhage, Multifocal                           1 (2%)                                                                       
      Hydronephrosis                                   1 (2%)                                                                       
      Infarct                                                       2 (4%)       1 (2%)                                             
      Inflammation, Multifocal, Subacute                                         2 (4%)       3 (6%)                                
      Inflammation, Necrotizing                        1 (2%)                    1 (2%)       1 (2%)                                
      Fat, Infiltration Cellular, Focal, Histiocyte    1 (2%)                                                                       
      Glomerulus, Inflammation, Proliferative          1 (2%)                                                                       
      Renal Tubule, Bacterium                          1 (2%)                    1 (2%)                                             
      Renal Tubule, Casts Protein, Multifocal          1 (2%)                                                                       
      Renal Tubule, Cyst                               1 (2%)                    1 (2%)                                             
   Urinary Bladder                                    (50)         (48)         (49)         (48)                                   
      Ectasia                                                                    1 (2%)                                             
      Thrombosis                                       1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
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