TDMS Study 05044-02 Pathology Tables
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
Facility: Battelle Columbus Laboratory
Chemical CAS #: 106-87-6
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7|
DAY ON TEST | 2| 5| 2| 2| 2| 2| 6| 2| 2| 9| 3| 3| 3| 3| 1| 0| 3| 3| 3| 0| 2| 3| 9| 3| 1|
| 9| 1| 9| 9| 9| 9| 4| 9| 9| 3| 0| 0| 0| 0| 9| 4| 0| 0| 0| 0| 1| 1| 7| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + M + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Necrosis, Coagulative | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | X |
Degeneration, Cystic | 2 |
Erythrophagocytosis | 3 |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X |
Inclusion Body Intracytoplasmic | 1 |
Necrosis, Coagulative, Multifocal | 2 |
Serosa, Fibrosis, Focal | |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Chronic | 2 |
Inflammation, Subacute | 2 |
Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Acinus, Atrophy | 1 3 4 3 |
Duct, Ectasia | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Erosion | |
Hyperkeratosis | 1 |
Inflammation, Chronic Active | |
Ulcer | 1 1 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7|
DAY ON TEST | 2| 5| 2| 2| 2| 2| 6| 2| 2| 9| 3| 3| 3| 3| 1| 0| 3| 3| 3| 0| 2| 3| 9| 3| 1|
| 9| 1| 9| 9| 9| 9| 4| 9| 9| 3| 0| 0| 0| 0| 9| 4| 0| 0| 0| 0| 1| 1| 7| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Valve, Bacterium | |
Valve, Inflammation, Subacute | |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 2 2 3 2 2 2 1 2 2 2 2 3 2 2 3 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M M + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Nodular | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Follicle, Cyst | |
Follicle, Hyperplasia, Nodular | 3 1 1 2 3 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 |
Cyst | X X X X X X X X X |
Hyperplasia, Tubular | 3 |
Bilateral, Atrophy | |
Bilateral, Cyst | X |
Bilateral, Hyperplasia, Tubular | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Endometrium, Hyperplasia, Cystic | 4 3 4 3 4 2 1 4 4 3 4 1 4 2 4 4 4 2 2 4 2 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7|
DAY ON TEST | 2| 5| 2| 2| 2| 2| 6| 2| 2| 9| 3| 3| 3| 3| 1| 0| 3| 3| 3| 0| 2| 3| 9| 3| 1|
| 9| 1| 9| 9| 9| 9| 4| 9| 9| 3| 0| 0| 0| 0| 9| 4| 0| 0| 0| 0| 1| 1| 7| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Sternal, Myelofibrosis, Multifocal | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + M + + + + +|
Infiltration Cellular, Histiocyte | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Amyloid Deposition | |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 |
Hematopoietic Cell Proliferation | 1 2|
__________________________________________________________________________|
Thymus | + M + + + + M + + + + + + + + + + + + M M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + M + + + M + + + M + + + + + + + M + + + +|
Inguinal, Hyperplasia, Cystic | 4 3 |
Inguinal, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 2 1 |
Edema | 4 |
Hyperkeratosis | 1 |
Inflammation, Necrotizing | 1 |
Parasite Metazoan | X |
Back, Acanthosis | 1 |
Back, Parasite Metazoan | X |
Scapula, Acanthosis | 1 1 2 |
Scapula, Hyperkeratosis | 1 |
Scapula, Inflammation, Chronic | 1 1 |
Scapula, Inflammation, Necrotizing | 3 |
Scapula, Parasite Metazoan | X |
Subcutaneous Tissue, Fibrosis | |
Subcutaneous Tissue, Necrosis, | |
Multifocal | 3 |
Subcutaneous Tissue, Scapula, | |
Necrosis, Multifocal | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Abdominal, Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Multifocal | |
Mineralization, Multifocal | 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7|
DAY ON TEST | 2| 5| 2| 2| 2| 2| 6| 2| 2| 9| 3| 3| 3| 3| 1| 0| 3| 3| 3| 0| 2| 3| 9| 3| 1|
| 9| 1| 9| 9| 9| 9| 4| 9| 9| 3| 0| 0| 0| 0| 9| 4| 0| 0| 0| 0| 1| 1| 7| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hypothalamus, Compression | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Diffuse | |
Hemorrhage, Multifocal | 1 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2|
Interstitium, Inflammation, Chronic | 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + M + M + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | 1 |
Thrombosis | X |
__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 5| 0| 5| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 6| 3| 7| 5| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 6| 9| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 9| 9| 3| 6| 3| 0|
| 1| 1| 1| 1| 1| 1| 4| 4| 3| 1| 2| 5| 5| 2| 2| 7| 2| 2| 2| 8| 2| 2| 9| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + M + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + M + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | |
Degeneration, Cystic | 2 |
Erythrophagocytosis | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | |
Inclusion Body Intracytoplasmic | 1 |
Necrosis, Coagulative, Multifocal | 2 |
Serosa, Fibrosis, Focal | 1 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic | |
Inflammation, Subacute | |
Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + M + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 1 4 4 3 |
Erosion | 3 |
Hyperkeratosis | 1 |
Inflammation, Chronic Active | 2 |
Ulcer | 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 5| 0| 5| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 6| 3| 7| 5| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 6| 9| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 9| 9| 3| 6| 3| 0|
| 1| 1| 1| 1| 1| 1| 4| 4| 3| 1| 2| 5| 5| 2| 2| 7| 2| 2| 2| 8| 2| 2| 9| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Valve, Bacterium | X |
Valve, Inflammation, Subacute | 4 |
Valve, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 1 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Nodular | 3 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X |
Follicle, Hyperplasia, Nodular | 2 1 2 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | +|
Duct, Dilatation | 2|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 |
Cyst | X X X X X X X X X X X |
Hyperplasia, Tubular | |
Bilateral, Atrophy | 4 4 4 |
Bilateral, Cyst | X X X|
Bilateral, Hyperplasia, Tubular | 2 2 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Endometrium, Hyperplasia, Cystic | 4 3 3 4 4 4 4 4 1 3 2 3 2 4 3 4 2 2 2 4 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis, Multifocal | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 5| 0| 5| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 6| 3| 7| 5| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 6| 9| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 9| 9| 3| 6| 3| 0|
| 1| 1| 1| 1| 1| 1| 4| 4| 3| 1| 2| 5| 5| 2| 2| 7| 2| 2| 2| 8| 2| 2| 9| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Sternal, Myelofibrosis, Multifocal | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Amyloid Deposition | 3 |
Sinus, Ectasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3|
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + M M M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Inguinal, Hyperplasia, Cystic | 1 2 |
Inguinal, Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Edema | 3|
Hyperkeratosis | |
Inflammation, Necrotizing | |
Parasite Metazoan | |
Back, Acanthosis | |
Back, Parasite Metazoan | |
Scapula, Acanthosis | 1 |
Scapula, Hyperkeratosis | |
Scapula, Inflammation, Chronic | |
Scapula, Inflammation, Necrotizing | 1 |
Scapula, Parasite Metazoan | X |
Subcutaneous Tissue, Fibrosis | 2 |
Subcutaneous Tissue, Necrosis, | |
Multifocal | |
Subcutaneous Tissue, Scapula, | |
Necrosis, Multifocal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Abdominal, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Multifocal | 1 |
Mineralization, Multifocal | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 5| 0| 5| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 6| 3| 7| 5| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 6| 9| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 9| 9| 3| 6| 3| 0|
| 1| 1| 1| 1| 1| 1| 4| 4| 3| 1| 2| 5| 5| 2| 2| 7| 2| 2| 2| 8| 2| 2| 9| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hypothalamus, Compression | 4 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Diffuse | 3 2 |
Hemorrhage, Multifocal | 2 3 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Interstitium, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | M + + + + + + M + + + + M + + + + + + + + + + I +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | |
Thrombosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 8| 9| 8| 9| 9| 8| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Gallbladder | | 48 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
Amyloid Deposition | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 50 |
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 50 |
Amyloid Deposition | | 1 2.0|
Necrosis, Coagulative | | 1 4.0|
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis | | 1 2.0|
Cyst | | 1 |
Degeneration, Cystic | | 2 2.0|
Erythrophagocytosis | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | | 1 |
Inclusion Body Intracytoplasmic | | 2 1.0|
Necrosis, Coagulative, Multifocal | | 2 2.0|
Serosa, Fibrosis, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Subacute | | 1 2.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Inflammation, Chronic | | 1 3.0|
Acinus, Atrophy | | 4 2.8|
Duct, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 49 |
Acanthosis | | 6 2.7|
Erosion | | 1 3.0|
Hyperkeratosis | | 2 1.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 8| 9| 8| 9| 9| 8| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | | 6 1.3|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Ulcer | | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Heart | | 50 |
Valve, Bacterium | | 1 |
Valve, Inflammation, Subacute | | 1 4.0|
Valve, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
Capsule, Hyperplasia | | 49 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Hyperplasia, Nodular | | 5 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Hyperplasia, Nodular | | 3 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 45 |
__________________________________________________________________________|____________|
Pituitary Gland | | 49 |
Pars Distalis, Hyperplasia, Nodular | | 4 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 49 |
Follicle, Cyst | | 1 |
Follicle, Hyperplasia, Nodular | | 14 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
Duct, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | | 50 |
Atrophy | | 9 4.0|
Cyst | | 20 |
Hyperplasia, Tubular | | 1 3.0|
Bilateral, Atrophy | | 3 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 8| 9| 8| 9| 9| 8| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Bilateral, Cyst | | 4 |
Bilateral, Hyperplasia, Tubular | | 4 2.3|
__________________________________________________________________________|____________|
Uterus | | 50 |
Inflammation, Chronic Active | | 1 3.0|
Endometrium, Hyperplasia, Cystic | | 44 3.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Femoral, Myelofibrosis, Multifocal | | 1 2.0|
Sternal, Myelofibrosis, Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | | 49 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 48 |
Infiltration Cellular, Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 6 |
Amyloid Deposition | | 1 3.0|
Sinus, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Depletion Lymphoid | | 2 3.0|
Hematopoietic Cell Proliferation | | 3 1.7|
__________________________________________________________________________|____________|
Thymus | | 42 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 44 |
Inguinal, Hyperplasia, Cystic | | 4 2.5|
Inguinal, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Skin | | 50 |
Acanthosis | | 4 1.3|
Edema | | 2 3.5|
Hyperkeratosis | | 1 1.0|
Inflammation, Necrotizing | | 1 1.0|
Parasite Metazoan | | 1 |
Back, Acanthosis | | 1 1.0|
Back, Parasite Metazoan | | 1 |
Scapula, Acanthosis | | 4 1.3|
Scapula, Hyperkeratosis | | 1 1.0|
Scapula, Inflammation, Chronic | | 2 1.0|
Scapula, Inflammation, Necrotizing | | 2 2.0|
Scapula, Parasite Metazoan | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 8| 9| 8| 9| 9| 8| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Subcutaneous Tissue, Fibrosis | | 1 2.0|
Subcutaneous Tissue, Necrosis, | | |
Multifocal | | 1 3.0|
Subcutaneous Tissue, Scapula, | | |
Necrosis, Multifocal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Abdominal, Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Hemorrhage, Multifocal | | 1 1.0|
Mineralization, Multifocal | | 28 1.0|
Hypothalamus, Compression | | 3 3.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion, Diffuse | | 2 2.5|
Hemorrhage, Multifocal | | 3 2.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Interstitium, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Nose | | 50 |
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 43 |
Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Inflammation, Necrotizing | | 1 1.0|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 2| 7| 7| 1| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 2| 0| 9| 2| 2| 5| 2| 2| 2| 2| 1| 2| 3| 3| 1| 3| 0| 3| 3| 0| 0| 3| 3| 4|
| 7| 9| 8| 6| 9| 9| 6| 9| 9| 9| 9| 1| 9| 0| 0| 5| 0| 9| 0| 0| 4| 9| 0| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
25 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Inclusion Body Intracytoplasmic | |
Necrosis, Coagulative, Multifocal | |
Thrombosis | X |
Centrilobular, Degeneration, Hydropic| 3 |
__________________________________________________________________________|
Mesentery | + + |
Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 |
Duct, Ectasia | 4 |
Duct, Mineralization, Multifocal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 |
Atrium Left, Thrombosis | X |
Coronary Artery, Inflammation, | |
Chronic | 1 |
Valve, Bacterium | X X X |
Valve, Inflammation, Subacute | 3 4 |
Valve, Thrombosis | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 1 2 2 1 3 2 2 2 2 1 3 2 3 2 3 2 3 2 3 3 2 2 3 3 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 2| 7| 7| 1| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 2| 0| 9| 2| 2| 5| 2| 2| 2| 2| 1| 2| 3| 3| 1| 3| 0| 3| 3| 0| 0| 3| 3| 4|
| 7| 9| 8| 6| 9| 9| 6| 9| 9| 9| 9| 1| 9| 0| 0| 5| 0| 9| 0| 0| 4| 9| 0| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
25 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia, Nodular | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Parathyroid Gland | M + + M + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Nodular | 2 |
__________________________________________________________________________|
Thyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Hyperplasia, Nodular | 2 2 3 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + M|
Atrophy | 4 4 |
Cyst | X X X X X X X X X X X |
Hyperplasia, Tubular | 2 3 4 1 |
Necrosis, Acute | 3 |
Thrombosis | X |
Bilateral, Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 |
Bilateral, Cyst | X X X X X |
Bilateral, Hyperplasia, Tubular | 2 1 2 1 2 1 3 1 2 2 2 2 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 1 3 1 4 1 2 2 3 2 3 4 1 3 2 2 2 2 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis, Multifocal | |
Femoral, Thrombosis | |
Sternal, Myelofibrosis, Multifocal | 2 1 2 2 2 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + |
Infiltration Cellular, | |
Polymorphonuclear | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 2 2 3 2 4 3|
Hyperplasia, Lymphoid | 3 |
Thrombosis | |
__________________________________________________________________________|
Thymus | + + + M + + M + + + + + + + + + + + + + + M + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 2| 7| 7| 1| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 2| 0| 9| 2| 2| 5| 2| 2| 2| 2| 1| 2| 3| 3| 1| 3| 0| 3| 3| 0| 0| 3| 3| 4|
| 7| 9| 8| 6| 9| 9| 6| 9| 9| 9| 9| 1| 9| 0| 0| 5| 0| 9| 0| 0| 4| 9| 0| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
25 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | M + + M + + + + + + + + + + M + + + + + + + + M +|
Inguinal, Hyperplasia, Cystic | 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Back, Hyperkeratosis | 1 |
Scapula, Acanthosis | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 |
Scapula, Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1|
Scapula, Inflammation, Chronic | 1 |
Scapula, Inflammation, Necrotizing | 1 |
Sebaceous Gland, Scapula, Hyperplasia| |
Subcutaneous Tissue, Necrosis, | |
Multifocal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Hypothalamus, Compression | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Diffuse | 4 |
Hemorrhage, Multifocal | 2 |
Alveolar Epithelium, Hyperplasia | |
Artery, Inflammation, Subacute | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | M + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + M + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 4| 7| 5| 4| 4|
DAY ON TEST | 3| 3| 3| 7| 0| 3| 2| 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 5| 5| 5|
| 1| 1| 1| 6| 9| 1| 2| 1| 1| 1| 1| 2| 5| 7| 2| 2| 2| 2| 2| 2| 7| 2| 3| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
25 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + M + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | 3 |
Inclusion Body Intracytoplasmic | 1 1 |
Necrosis, Coagulative, Multifocal | 2 |
Thrombosis | |
Centrilobular, Degeneration, Hydropic| |
__________________________________________________________________________|
Mesentery | + + |
Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + A |
Acinus, Atrophy | 4 3 |
Duct, Ectasia | 4 4 |
Duct, Mineralization, Multifocal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + M |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | |
Atrium Left, Thrombosis | |
Coronary Artery, Inflammation, | |
Chronic | |
Valve, Bacterium | |
Valve, Inflammation, Subacute | |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + |
Capsule, Hyperplasia | 2 2 3 2 2 3 2 3 3 3 3 2 2 2 3 2 4 2 2 2 1 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 4| 7| 5| 4| 4|
DAY ON TEST | 3| 3| 3| 7| 0| 3| 2| 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 5| 5| 5|
| 1| 1| 1| 6| 9| 1| 2| 1| 1| 1| 1| 2| 5| 7| 2| 2| 2| 2| 2| 2| 7| 2| 3| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
25 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia, Nodular | 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Hyperplasia, Nodular | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + |
Follicle, Hyperplasia, Nodular | 2 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + |
Atrophy | 4 4 4 4 4 4 4 4 4 |
Cyst | X X X X X X X X X X X |
Hyperplasia, Tubular | 2 1 1 1 1 2 3 3 1 1 1 |
Necrosis, Acute | 4 |
Thrombosis | X |
Bilateral, Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 |
Bilateral, Cyst | |
Bilateral, Hyperplasia, Tubular | 1 1 2 1 4 1 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + M + + + |
Endometrium, Hyperplasia, Cystic | 2 1 2 2 3 3 2 3 2 1 2 2 2 2 4 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + |
Femoral, Myelofibrosis, Multifocal | 1 1 |
Femoral, Thrombosis | X |
Sternal, Myelofibrosis, Multifocal | 2 2 2 1 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
Infiltration Cellular, | |
Polymorphonuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + |
Depletion Lymphoid | 3 3 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | |
Thrombosis | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 4| 7| 5| 4| 4|
DAY ON TEST | 3| 3| 3| 7| 0| 3| 2| 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 5| 5| 5|
| 1| 1| 1| 6| 9| 1| 2| 1| 1| 1| 1| 2| 5| 7| 2| 2| 2| 2| 2| 2| 7| 2| 3| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
25 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + M M + + M |
Inguinal, Hyperplasia, Cystic | 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + |
Back, Hyperkeratosis | |
Scapula, Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 |
Scapula, Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Scapula, Inflammation, Chronic | 1 |
Scapula, Inflammation, Necrotizing | 1 1 1 2 |
Sebaceous Gland, Scapula, Hyperplasia| 2 |
Subcutaneous Tissue, Necrosis, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + |
Mineralization, Multifocal | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Hypothalamus, Compression | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + |
Congestion, Diffuse | |
Hemorrhage, Multifocal | |
Alveolar Epithelium, Hyperplasia | 2 |
Artery, Inflammation, Subacute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + M + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 3| 5| 5| 5| 5| 5| 5| 2| | |
| 8| 9| 1| 8| 9| 8| 8| 8| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
25 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 50 |
__________________________________________________________________________|____________|
Gallbladder | + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 49 |
__________________________________________________________________________|____________|
Intestine Small | + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 50 |
__________________________________________________________________________|____________|
Liver | + + | 50 |
Basophilic Focus | | 1 3.0|
Inclusion Body Intracytoplasmic | | 2 1.0|
Necrosis, Coagulative, Multifocal | | 1 2.0|
Thrombosis | | 1 |
Centrilobular, Degeneration, Hydropic| | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + | 49 |
Acinus, Atrophy | 1 | 5 2.0|
Duct, Ectasia | 4 | 4 4.0|
Duct, Mineralization, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + | 49 |
__________________________________________________________________________|____________|
Stomach | + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 49 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + | 50 |
Cardiomyopathy | | 1 3.0|
Atrium Left, Thrombosis | | 1 |
Coronary Artery, Inflammation, | | |
Chronic | | 1 1.0|
Valve, Bacterium | | 3 |
Valve, Inflammation, Subacute | | 2 3.5|
Valve, Thrombosis | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 3| 5| 5| 5| 5| 5| 5| 2| | |
| 8| 9| 1| 8| 9| 8| 8| 8| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
25 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + | 50 |
Capsule, Hyperplasia | 1 2 | 50 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + | 50 |
Hyperplasia, Nodular | | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + | 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 50 |
Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M M | 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + M | 48 |
Pars Distalis, Hyperplasia, Nodular | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + | 49 |
Follicle, Hyperplasia, Nodular | | 13 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + | 49 |
Atrophy | | 11 4.0|
Cyst | | 22 |
Hyperplasia, Tubular | | 15 1.8|
Necrosis, Acute | | 2 3.5|
Thrombosis | | 2 |
Bilateral, Atrophy | | 32 4.0|
Bilateral, Cyst | | 5 |
Bilateral, Hyperplasia, Tubular | | 20 1.7|
__________________________________________________________________________|____________|
Uterus | + + | 49 |
Endometrium, Hyperplasia, Cystic | 3 | 36 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 50 |
Femoral, Myelofibrosis, Multifocal | | 2 1.0|
Femoral, Thrombosis | | 1 |
Sternal, Myelofibrosis, Multifocal | | 12 1.6|
__________________________________________________________________________|____________|
Lymph Node | + I | 49 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + I | 49 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 3| 5| 5| 5| 5| 5| 5| 2| | |
| 8| 9| 1| 8| 9| 8| 8| 8| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
25 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Infiltration Cellular, | | |
Polymorphonuclear | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + | 50 |
Depletion Lymphoid | 2 3 | 4 2.8|
Hematopoietic Cell Proliferation | | 7 2.6|
Hyperplasia, Lymphoid | | 1 3.0|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Thymus | + M | 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M | 41 |
Inguinal, Hyperplasia, Cystic | | 4 1.5|
__________________________________________________________________________|____________|
Skin | + + | 50 |
Back, Hyperkeratosis | | 1 1.0|
Scapula, Acanthosis | | 31 1.1|
Scapula, Hyperkeratosis | 1 | 27 1.0|
Scapula, Inflammation, Chronic | | 2 1.0|
Scapula, Inflammation, Necrotizing | | 5 1.2|
Sebaceous Gland, Scapula, Hyperplasia| | 1 2.0|
Subcutaneous Tissue, Necrosis, | | |
Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 50 |
Mineralization, Multifocal | 1 | 36 1.0|
Hypothalamus, Compression | | 2 3.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + | 50 |
Congestion, Diffuse | | 1 4.0|
Hemorrhage, Multifocal | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Artery, Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 3| 5| 5| 5| 5| 5| 5| 2| | |
| 8| 9| 1| 8| 9| 8| 8| 8| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
25 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | M + | 46 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 50 |
__________________________________________________________________________|____________|
Urinary Bladder | + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 4| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 5| 6| 0| 7| 5| 7| 7| 7| 4| 4| 0| 5| 5| 7|
DAY ON TEST | 0| 7| 2| 0| 6| 2| 2| 2| 8| 0| 3| 7| 8| 0| 3| 7| 3| 1| 3| 9| 6| 4| 8| 7| 0|
| 2| 9| 9| 0| 6| 9| 9| 9| 4| 5| 0| 9| 9| 3| 0| 2| 0| 9| 0| 5| 4| 5| 4| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2|
Angiectasis | |
Cyst | |
Hematopoietic Cell Proliferation | 1 1 |
Inclusion Body Intracytoplasmic | 1 |
Inflammation, Chronic Active, | |
Multifocal | 1 1 1 1|
Necrosis, Coagulative, Multifocal | 2 2|
Necrosis, Caseous, Multifocal | 2 |
Thrombosis | X |
Sinusoid, Centrilobular, Dilatation | 2 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Inflammation, Chronic | 3 |
Inflammation, Granulomatous | |
Acinus, Atrophy | 1 1 1|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Multifocal, Subacute | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Bacterium | |
Aorta, Inflammation, Chronic Active | |
Aorta, Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Coronary Artery, Inflammation, | |
Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 4| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 5| 6| 0| 7| 5| 7| 7| 7| 4| 4| 0| 5| 5| 7|
DAY ON TEST | 0| 7| 2| 0| 6| 2| 2| 2| 8| 0| 3| 7| 8| 0| 3| 7| 3| 1| 3| 9| 6| 4| 8| 7| 0|
| 2| 9| 9| 0| 6| 9| 9| 9| 4| 5| 0| 9| 9| 3| 0| 2| 0| 9| 0| 5| 4| 5| 4| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Myocardium, Inflammation, Chronic, | |
Multifocal | 1 1 |
Myocardium, Inflammation, Focal, | |
Subacute | 2|
Valve, Bacterium | |
Valve, Thrombosis | X|
Vein, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Capsule, Hyperplasia | |
Capsule, Hyperplasia | 2 1 2 3 2 4 4 2 2 3 2 3 3 1 2 3 2 2 1 2 3 1 2 2 1|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 |
Hyperplasia, Nodular | |
Inflammation, Subacute | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Nodular | 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Follicle, Hyperplasia, Nodular | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + M + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 |
Congestion | |
Cyst | X X X X X X X X X X|
Hyperplasia, Tubular | 2 3 3 1 1 1 3 3 2 |
Infiltration Cellular, Lymphocyte | |
Thrombosis | |
Bilateral, Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 3|
Bilateral, Cyst | X X X X |
Bilateral, Hyperplasia, Tubular | 1 2 2 3 2 3 2 1 3|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 1 1 2 1 2 3 2 2 2 4 3 2 1 4 3 1 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 4| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 5| 6| 0| 7| 5| 7| 7| 7| 4| 4| 0| 5| 5| 7|
DAY ON TEST | 0| 7| 2| 0| 6| 2| 2| 2| 8| 0| 3| 7| 8| 0| 3| 7| 3| 1| 3| 9| 6| 4| 8| 7| 0|
| 2| 9| 9| 0| 6| 9| 9| 9| 4| 5| 0| 9| 9| 3| 0| 2| 0| 9| 0| 5| 4| 5| 4| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + M + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Infiltration Cellular, | |
Mononuclear Cell | 2 |
Mediastinal, Infiltration Cellular, | |
Polymorphonuclear | 1 |
Pancreatic, Infiltration Cellular, | |
Polymorphonuclear | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + + + +|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + +|
Hematopoietic Cell Proliferation | 2 |
Infiltration Cellular, | |
Polymorphonuclear | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2|
Depletion Lymphoid | 3 3 2 |
Hematopoietic Cell Proliferation | 3 1 4 4 2 3 4 3 1 4 4 3|
__________________________________________________________________________|
Thymus | M M M M M + + + M + + + M + + + M + M M + + + M M|
Ectopic Thyroid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + M + + + + + + M M + + +|
Inguinal, Hyperplasia, Cystic | 3 2 |
Inguinal, Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 1 |
Hyperkeratosis | 1 1 1 |
Inflammation, Chronic | |
Inflammation, Necrotizing | 3 3 |
Back, Acanthosis | 1 1 2 |
Back, Hyperkeratosis | 1 1 1 |
Back, Inflammation, Necrotizing | 1 3 2|
Scapula, Acanthosis | 2 2 1 1 1 1 1 1 2 2 1 3 2 2 2 1 1 1 1|
Scapula, Hyperkeratosis | 2 1 1 1 1 1 1 1 1 1 1 1 1 2|
Scapula, Inflammation, Necrotizing | 2 2 1 3 3 3 3 1 2 1 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + I + + + + + + + + + + + + +|
Humerus, Proliferation | 4 |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 4| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 5| 6| 0| 7| 5| 7| 7| 7| 4| 4| 0| 5| 5| 7|
DAY ON TEST | 0| 7| 2| 0| 6| 2| 2| 2| 8| 0| 3| 7| 8| 0| 3| 7| 3| 1| 3| 9| 6| 4| 8| 7| 0|
| 2| 9| 9| 0| 6| 9| 9| 9| 4| 5| 0| 9| 9| 3| 0| 2| 0| 9| 0| 5| 4| 5| 4| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Hypothalamus, Compression | 4 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Diffuse | 2 |
Hemorrhage, Focal | 1 |
Hemorrhage, Multifocal | 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + I + + + M + + + + + + + + + + + M + + + + + +|
Inflammation, Subacute | 2 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Inflammation, Multifocal, Subacute | |
Inflammation, Necrotizing | |
Renal Tubule, Bacterium | |
Renal Tubule, Casts Protein, | |
Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + + + + + +|
Wall, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 5| 7| 0| 7| 4| 4| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 4| 6|
DAY ON TEST | 6| 3| 4| 3| 3| 2| 9| 2| 0| 2| 5| 3| 6| 3| 3| 8| 2| 2| 3| 6| 9| 7| 3| 9| 0|
| 9| 1| 8| 1| 0| 4| 4| 6| 4| 5| 2| 6| 6| 1| 2| 3| 6| 6| 2| 6| 8| 7| 2| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
50 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Angiectasis | 3 |
Cyst | X X |
Hematopoietic Cell Proliferation | 2 |
Inclusion Body Intracytoplasmic | 3 |
Inflammation, Chronic Active, | |
Multifocal | 1 2 |
Necrosis, Coagulative, Multifocal | 2 3 |
Necrosis, Caseous, Multifocal | |
Thrombosis | X X X X |
Sinusoid, Centrilobular, Dilatation | |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
Inflammation, Chronic | |
Inflammation, Granulomatous | 3 |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Multifocal, Subacute | 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + +|
Aorta, Bacterium | X|
Aorta, Inflammation, Chronic Active | 2 |
Aorta, Thrombosis | X|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Coronary Artery, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 5| 7| 0| 7| 4| 4| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 4| 6|
DAY ON TEST | 6| 3| 4| 3| 3| 2| 9| 2| 0| 2| 5| 3| 6| 3| 3| 8| 2| 2| 3| 6| 9| 7| 3| 9| 0|
| 9| 1| 8| 1| 0| 4| 4| 6| 4| 5| 2| 6| 6| 1| 2| 3| 6| 6| 2| 6| 8| 7| 2| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
50 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Myocardium, Inflammation, Chronic, | |
Multifocal | 1 |
Myocardium, Inflammation, Focal, | |
Subacute | |
Valve, Bacterium | X |
Valve, Thrombosis | X |
Vein, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Capsule, Hyperplasia | 2 |
Capsule, Hyperplasia | 4 3 3 4 2 2 2 2 2 2 2 4 2 2 2 3 3 3 2 3 3 3|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Nodular | 1 |
Inflammation, Subacute | 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + M + M + + + + + M + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | M + + + + + M + + + + + + + M + + + + + + + + + +|
Pars Distalis, Hyperplasia, Nodular | 1 3 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Follicle, Hyperplasia, Nodular | 2 3 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 |
Congestion | 3 |
Cyst | X X X X X X|
Hyperplasia, Tubular | 3 3 2 1 2 4 2 2 |
Infiltration Cellular, Lymphocyte | 4 |
Thrombosis | X |
Bilateral, Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Bilateral, Cyst | X X X X X X |
Bilateral, Hyperplasia, Tubular | 3 2 3 2 3 2 2 1 3 2 2 3|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 1 2 2 2 2 3 2 1 3 3 4 1 2 1 1 2 1 4 2 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 5| 7| 0| 7| 4| 4| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 4| 6|
DAY ON TEST | 6| 3| 4| 3| 3| 2| 9| 2| 0| 2| 5| 3| 6| 3| 3| 8| 2| 2| 3| 6| 9| 7| 3| 9| 0|
| 9| 1| 8| 1| 0| 4| 4| 6| 4| 5| 2| 6| 6| 1| 2| 3| 6| 6| 2| 6| 8| 7| 2| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
50 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + M M + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | 4 |
Mediastinal, Infiltration Cellular, | |
Mononuclear Cell | |
Mediastinal, Infiltration Cellular, | |
Polymorphonuclear | |
Pancreatic, Infiltration Cellular, | |
Polymorphonuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M M + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | +|
Hematopoietic Cell Proliferation | |
Infiltration Cellular, | |
Polymorphonuclear | 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2|
Depletion Lymphoid | 2 |
Hematopoietic Cell Proliferation | 2 2 3 2 4 2 3 4 4 4 2 2 4 3 3 2|
__________________________________________________________________________|
Thymus | M + + + + + M + + M + + + + + + + + + M + + M + +|
Ectopic Thyroid | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + M + + + M + + M + + + + + + + + M M + +|
Inguinal, Hyperplasia, Cystic | 2 |
Inguinal, Inflammation, Chronic | 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 |
Hyperkeratosis | 1 1 |
Inflammation, Chronic | 2 1 2 |
Inflammation, Necrotizing | 3 2 3 4|
Back, Acanthosis | 2 2 |
Back, Hyperkeratosis | 1 |
Back, Inflammation, Necrotizing | 1 3 |
Scapula, Acanthosis | 1 2 2 2 1 3 1 1 1 1 1 2 2 2 1 1 1 1 2 2 1 3|
Scapula, Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Scapula, Inflammation, Necrotizing | 1 3 2 1 3|
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Humerus, Proliferation | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 5| 7| 0| 7| 4| 4| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 4| 6|
DAY ON TEST | 6| 3| 4| 3| 3| 2| 9| 2| 0| 2| 5| 3| 6| 3| 3| 8| 2| 2| 3| 6| 9| 7| 3| 9| 0|
| 9| 1| 8| 1| 0| 4| 4| 6| 4| 5| 2| 6| 6| 1| 2| 3| 6| 6| 2| 6| 8| 7| 2| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
50 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 1 1 1 1 1 1 1 1 1 1 |
Hypothalamus, Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Diffuse | |
Hemorrhage, Focal | |
Hemorrhage, Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + I + + I + + + + + + I + + I M +|
Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Inflammation, Multifocal, Subacute | 2 |
Inflammation, Necrotizing | 4 |
Renal Tubule, Bacterium | X |
Renal Tubule, Casts Protein, | |
Multifocal | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Wall, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 8| 9| 9| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Gallbladder | | 48 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 50 |
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 50 |
__________________________________________________________________________|____________|
Liver | | 50 |
Amyloid Deposition | | 1 2.0|
Angiectasis | | 1 3.0|
Cyst | | 2 |
Hematopoietic Cell Proliferation | | 3 1.3|
Inclusion Body Intracytoplasmic | | 2 2.0|
Inflammation, Chronic Active, | | |
Multifocal | | 6 1.2|
Necrosis, Coagulative, Multifocal | | 4 2.3|
Necrosis, Caseous, Multifocal | | 1 2.0|
Thrombosis | | 5 |
Sinusoid, Centrilobular, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Ectopic Tissue | | 1 |
Inflammation, Chronic | | 1 3.0|
Inflammation, Granulomatous | | 1 3.0|
Acinus, Atrophy | | 3 1.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
Inflammation, Multifocal, Subacute | | 2 1.5|
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
Aorta, Bacterium | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 8| 9| 9| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Aorta, Inflammation, Chronic Active | | 1 2.0|
Aorta, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Heart | | 50 |
Coronary Artery, Inflammation, | | |
Chronic | | 1 1.0|
Myocardium, Inflammation, Chronic, | | |
Multifocal | | 3 1.0|
Myocardium, Inflammation, Focal, | | |
Subacute | | 1 2.0|
Valve, Bacterium | | 1 |
Valve, Thrombosis | | 2 |
Vein, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
Bilateral, Capsule, Hyperplasia | | 1 2.0|
Capsule, Hyperplasia | | 47 2.4|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia, Nodular | | 1 1.0|
Inflammation, Subacute | | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 44 |
__________________________________________________________________________|____________|
Pituitary Gland | | 47 |
Pars Distalis, Hyperplasia, Nodular | | 4 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Cyst | | 1 |
Follicle, Hyperplasia, Nodular | | 5 2.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 49 |
Atrophy | | 13 4.0|
Congestion | | 1 3.0|
Cyst | | 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 8| 9| 9| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia, Tubular | | 17 2.2|
Infiltration Cellular, Lymphocyte | | 1 4.0|
Thrombosis | | 1 |
Bilateral, Atrophy | | 29 4.0|
Bilateral, Cyst | | 10 |
Bilateral, Hyperplasia, Tubular | | 21 2.2|
__________________________________________________________________________|____________|
Uterus | | 49 |
Endometrium, Hyperplasia, Cystic | | 38 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
__________________________________________________________________________|____________|
Lymph Node | | 47 |
Mediastinal, Hyperplasia, Lymphoid | | 1 4.0|
Mediastinal, Infiltration Cellular, | | |
Mononuclear Cell | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Polymorphonuclear | | 1 1.0|
Pancreatic, Infiltration Cellular, | | |
Polymorphonuclear | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 47 |
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 6 |
Hematopoietic Cell Proliferation | | 1 2.0|
Infiltration Cellular, | | |
Polymorphonuclear | | 2 2.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Amyloid Deposition | | 2 2.0|
Depletion Lymphoid | | 4 2.5|
Hematopoietic Cell Proliferation | | 28 2.9|
__________________________________________________________________________|____________|
Thymus | | 33 |
Ectopic Thyroid | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 41 |
Inguinal, Hyperplasia, Cystic | | 3 2.3|
Inguinal, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Skin | | 50 |
Acanthosis | | 5 1.0|
Hyperkeratosis | | 5 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 8| 9| 9| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 3 1.7|
Inflammation, Necrotizing | | 6 3.0|
Back, Acanthosis | | 5 1.6|
Back, Hyperkeratosis | | 4 1.0|
Back, Inflammation, Necrotizing | | 5 2.0|
Scapula, Acanthosis | | 41 1.5|
Scapula, Hyperkeratosis | | 29 1.1|
Scapula, Inflammation, Necrotizing | | 15 2.1|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 49 |
Humerus, Proliferation | | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Mineralization, Multifocal | | 24 1.0|
Hypothalamus, Compression | | 2 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion, Diffuse | | 1 2.0|
Hemorrhage, Focal | | 1 1.0|
Hemorrhage, Multifocal | | 2 1.5|
__________________________________________________________________________|____________|
Nose | | 50 |
__________________________________________________________________________|____________|
Trachea | | 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 42 |
Inflammation, Subacute | | 2 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Amyloid Deposition | | 1 2.0|
Inflammation, Multifocal, Subacute | | 1 2.0|
Inflammation, Necrotizing | | 1 4.0|
Renal Tubule, Bacterium | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 8| 9| 9| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Casts Protein, | | |
Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 48 |
Wall, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 5| 5| 4| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 4| 5| 1| 5| 5| 5| 4| 3| 5| 5|
DAY ON TEST | 3| 0| 7| 4| 7| 3| 5| 4| 6| 9| 9| 3| 5| 7| 6| 6| 4| 8| 9| 9| 9| 7| 8| 9| 5|
| 2| 3| 4| 9| 6| 5| 8| 1| 2| 3| 3| 5| 0| 8| 2| 4| 1| 6| 3| 3| 3| 4| 8| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
100 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Basophilic Focus | 2 |
Hematopoietic Cell Proliferation | 2 3 |
Inclusion Body Intracytoplasmic | |
Inflammation, Chronic Active, | |
Multifocal | 1 1 3 |
Necrosis, Coagulative, Multifocal | 3 1 2 1 1 3 |
Thrombosis | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypoplasia | |
Acinus, Atrophy | 1|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 3 |
Inflammation, Chronic Active | 2 |
Ulcer | 1 1 1|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Acute | 1 2 |
__________________________________________________________________________|
Tooth | |
Gingiva, Abscess | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Aorta, Bacterium | X X |
Aorta, Inflammation, Chronic Active | 4 4 |
Aorta, Thrombosis | X X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Focal, | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 5| 5| 4| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 4| 5| 1| 5| 5| 5| 4| 3| 5| 5|
DAY ON TEST | 3| 0| 7| 4| 7| 3| 5| 4| 6| 9| 9| 3| 5| 7| 6| 6| 4| 8| 9| 9| 9| 7| 8| 9| 5|
| 2| 3| 4| 9| 6| 5| 8| 1| 2| 3| 3| 5| 0| 8| 2| 4| 1| 6| 3| 3| 3| 4| 8| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
100 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Subacute | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Hyperplasia | 3 |
Capsule, Hyperplasia | 2 2 2 2 1 2 2 3 1 2 3 1 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
Hematopoietic Cell Proliferation | |
Hyperplasia, Nodular | 2 1 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + M + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + I + + I + M + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Nodular | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 |
Cyst | X X X X X X X X X|
Hemorrhage | 4 |
Hyperplasia, Tubular | 3 3 3 2 4 2 2 2 1 2 |
Bilateral, Atrophy | 4 4 4 3 4 4 4 4 4 4 2 4 4 4 4 4 4 4|
Bilateral, Cyst | 2 X X X |
Bilateral, Hyperplasia, Tubular | 3 2 2 2 1 2|
Periovarian Tissue, Inflammation, | |
Subacute | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Endometrium, Fibrosis | 2 |
Endometrium, Hyperplasia, Cystic | 2 1 2 3 2 2 4 2 3 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis, Multifocal | 3 1|
Femoral, Necrosis, Caseous | |
Sternal, Myelofibrosis, Multifocal | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 5| 5| 4| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 4| 5| 1| 5| 5| 5| 4| 3| 5| 5|
DAY ON TEST | 3| 0| 7| 4| 7| 3| 5| 4| 6| 9| 9| 3| 5| 7| 6| 6| 4| 8| 9| 9| 9| 7| 8| 9| 5|
| 2| 3| 4| 9| 6| 5| 8| 1| 2| 3| 3| 5| 0| 8| 2| 4| 1| 6| 3| 3| 3| 4| 8| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
100 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Infiltration Cellular, | |
Polymorphonuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, | |
Polymorphonuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + +|
Hematopoietic Cell Proliferation | |
Infiltration Cellular, | |
Polymorphonuclear | 4 1|
Sinus, Ectasia | 3|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Depletion Lymphoid | 3 |
Hematopoietic Cell Proliferation | 4 4 4 4 1 3 2 3 4 4 4 4 4 2 3 |
__________________________________________________________________________|
Thymus | + M + + M + M + M M + + M + + + + + M + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + M + + + M + + M M M + + + + + + M|
Cervical, Atypia Cytologic | 3 |
Inguinal, Hyperplasia, Cystic | 3 1 2 2 2 |
Inguinal, Inflammation, Acute | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Acanthosis | 1 2 |
Hyperkeratosis | 1 1 |
Inflammation, Chronic | |
Inflammation, Necrotizing | 3 2 |
Back, Acanthosis | 2 2 |
Back, Hyperkeratosis | |
Back, Inflammation, Necrotizing | 3 |
Scapula, Abscess | 3 3 |
Scapula, Acanthosis | 1 2 3 1 1 2 2 3 1 2 2 2 3 1 2 2 2 1 2 2|
Scapula, Hyperkeratosis | 1 1 2 1 1 1 1 1 2 1 1 2|
Scapula, Inflammation, Necrotizing | 2 3 4 3 1 2 2 3 4 2 3 3|
Subcutaneous Tissue, Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 5| 5| 4| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 4| 5| 1| 5| 5| 5| 4| 3| 5| 5|
DAY ON TEST | 3| 0| 7| 4| 7| 3| 5| 4| 6| 9| 9| 3| 5| 7| 6| 6| 4| 8| 9| 9| 9| 7| 8| 9| 5|
| 2| 3| 4| 9| 6| 5| 8| 1| 2| 3| 3| 5| 0| 8| 2| 4| 1| 6| 3| 3| 3| 4| 8| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
100 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Multifocal | 3 1 |
Inflammation, Focal, Suppurative | 2 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Artery, Inflammation, Subacute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Inflammation, Acute | 2 |
Nerve, Nares, Inflammation, Subacute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + M + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia, Nodular | |
Inflammation, Necrotizing | 1 |
Inflammation, Subacute | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Multifocal, Subacute | 2 2 |
Inflammation, Necrotizing | |
Renal Tubule, Bacterium | |
Renal Tubule, Casts Protein, | |
Multifocal | 2 |
Renal Tubule, Mineralization, | |
Multifocal | 1 |
Renal Tubule, Necrosis, Coagulative, | |
Multifocal | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 5| 5| 5| 5| 4| 5| 0| 5| 5| 5| 4| 5| 4| 5|
DAY ON TEST | 8| 7| 4| 9| 5| 7| 7| 1| 9| 4| 0| 5| 2| 9| 9| 9| 2| 0| 9| 7| 7| 3| 9| 9| 9|
| 7| 9| 4| 3| 8| 9| 9| 9| 9| 4| 7| 0| 3| 3| 3| 9| 3| 2| 3| 8| 9| 1| 3| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
100 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Basophilic Focus | |
Hematopoietic Cell Proliferation | |
Inclusion Body Intracytoplasmic | 1 |
Inflammation, Chronic Active, | |
Multifocal | 2 1 |
Necrosis, Coagulative, Multifocal | 2 2 |
Thrombosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypoplasia | 4 |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Coagulative | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Acute | 2 1 |
__________________________________________________________________________|
Tooth | + |
Gingiva, Abscess | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Bacterium | |
Aorta, Inflammation, Chronic Active | |
Aorta, Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Focal, | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 5| 5| 5| 5| 4| 5| 0| 5| 5| 5| 4| 5| 4| 5|
DAY ON TEST | 8| 7| 4| 9| 5| 7| 7| 1| 9| 4| 0| 5| 2| 9| 9| 9| 2| 0| 9| 7| 7| 3| 9| 9| 9|
| 7| 9| 4| 3| 8| 9| 9| 9| 9| 4| 7| 0| 3| 3| 3| 9| 3| 2| 3| 8| 9| 1| 3| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
100 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Subacute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Hyperplasia | |
Capsule, Hyperplasia | 3 2 2 2 3 3 2 2 2 1 2 1 2 3 2 2 2 1 2 1 2 3 2 4 3|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Nodular | |
Inflammation, Chronic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + M M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + I + + + + + + + + + + M + +|
Pars Distalis, Hyperplasia, Nodular | 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Cyst | X X X X X X X |
Hemorrhage | 3 |
Hyperplasia, Tubular | 1 4 2 |
Bilateral, Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Bilateral, Cyst | X X X X X X|
Bilateral, Hyperplasia, Tubular | 2 2 2 1 3 4 2 1 3 1 2 2 2 2 2|
Periovarian Tissue, Inflammation, | |
Subacute | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
Endometrium, Fibrosis | |
Endometrium, Hyperplasia, Cystic | 1 1 4 2 2 1 1 2 2 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis, Multifocal | |
Femoral, Necrosis, Caseous | 4 |
Sternal, Myelofibrosis, Multifocal | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 5| 5| 5| 5| 4| 5| 0| 5| 5| 5| 4| 5| 4| 5|
DAY ON TEST | 8| 7| 4| 9| 5| 7| 7| 1| 9| 4| 0| 5| 2| 9| 9| 9| 2| 0| 9| 7| 7| 3| 9| 9| 9|
| 7| 9| 4| 3| 8| 9| 9| 9| 9| 4| 7| 0| 3| 3| 3| 9| 3| 2| 3| 8| 9| 1| 3| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
100 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Infiltration Cellular, | |
Polymorphonuclear | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, | |
Polymorphonuclear | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
Hematopoietic Cell Proliferation | 2 |
Infiltration Cellular, | |
Polymorphonuclear | 3 |
Sinus, Ectasia | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 |
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 3 4 3 4 4 3 2 3 3 4 2 2 4 2 3 |
__________________________________________________________________________|
Thymus | M + + + + M + M + M + M + + + M + + + M + + M M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M I + M + M + + + + + + + + +|
Cervical, Atypia Cytologic | |
Inguinal, Hyperplasia, Cystic | 2 1 2 4 |
Inguinal, Inflammation, Acute | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Acanthosis | 1 1 |
Hyperkeratosis | |
Inflammation, Chronic | 3 |
Inflammation, Necrotizing | 3 3 3 3 |
Back, Acanthosis | 1 1 |
Back, Hyperkeratosis | 1 1 |
Back, Inflammation, Necrotizing | |
Scapula, Abscess | |
Scapula, Acanthosis | 2 2 2 2 2 3 2 1 1 2 2 1 2 1 3 1 |
Scapula, Hyperkeratosis | 2 1 1 1 1 1 1 1 |
Scapula, Inflammation, Necrotizing | 3 2 3 2 |
Subcutaneous Tissue, Fibrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 5| 5| 5| 5| 4| 5| 0| 5| 5| 5| 4| 5| 4| 5|
DAY ON TEST | 8| 7| 4| 9| 5| 7| 7| 1| 9| 4| 0| 5| 2| 9| 9| 9| 2| 0| 9| 7| 7| 3| 9| 9| 9|
| 7| 9| 4| 3| 8| 9| 9| 9| 9| 4| 7| 0| 3| 3| 3| 9| 3| 2| 3| 8| 9| 1| 3| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
100 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Multifocal | |
Inflammation, Focal, Suppurative | 3 |
Alveolar Epithelium, Hyperplasia | 1|
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Artery, Inflammation, Subacute | 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Inflammation, Acute | |
Nerve, Nares, Inflammation, Subacute | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | M + + + + + + + + + I + + + + + + + + I + + + + +|
Hyperplasia, Nodular | 1 |
Inflammation, Necrotizing | |
Inflammation, Subacute | 3 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Multifocal, Subacute | |
Inflammation, Necrotizing | 4 |
Renal Tubule, Bacterium | X |
Renal Tubule, Casts Protein, | |
Multifocal | |
Renal Tubule, Mineralization, | |
Multifocal | |
Renal Tubule, Necrosis, Coagulative, | |
Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 4 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 8| 9| 9| 8| 8| 9| 9| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
100 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Gallbladder | | 49 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
Inflammation, Necrotizing | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 50 |
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
Inflammation, Necrotizing | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 50 |
__________________________________________________________________________|____________|
Liver | | 50 |
Amyloid Deposition | | 1 2.0|
Basophilic Focus | | 1 2.0|
Hematopoietic Cell Proliferation | | 2 2.5|
Inclusion Body Intracytoplasmic | | 1 1.0|
Inflammation, Chronic Active, | | |
Multifocal | | 5 1.6|
Necrosis, Coagulative, Multifocal | | 8 1.9|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 50 |
Hypoplasia | | 1 4.0|
Acinus, Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
Necrosis, Coagulative | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Acanthosis | | 2 2.0|
Inflammation, Chronic Active | | 1 2.0|
Ulcer | | 3 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Hyperplasia | | 1 2.0|
Inflammation, Acute | | 4 1.5|
__________________________________________________________________________|____________|
Tooth | | 1 |
Gingiva, Abscess | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 8| 9| 9| 8| 8| 9| 9| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
100 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Aorta, Bacterium | | 2 |
Aorta, Inflammation, Chronic Active | | 2 4.0|
Aorta, Thrombosis | | 2 |
__________________________________________________________________________|____________|
Heart | | 50 |
Myocardium, Inflammation, Focal, | | |
Subacute | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
Bilateral, Hyperplasia | | 1 3.0|
Capsule, Hyperplasia | | 47 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 49 |
Ectopic Tissue | | 1 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Nodular | | 2 1.5|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 45 |
__________________________________________________________________________|____________|
Pituitary Gland | | 45 |
Pars Distalis, Hyperplasia, Nodular | | 3 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 50 |
Atrophy | | 8 4.0|
Cyst | | 16 |
Hemorrhage | | 2 3.5|
Hyperplasia, Tubular | | 13 2.4|
Bilateral, Atrophy | | 39 3.9|
Bilateral, Cyst | | 10 2.0|
Bilateral, Hyperplasia, Tubular | | 21 2.0|
Periovarian Tissue, Inflammation, | | |
Subacute | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 8| 9| 9| 8| 8| 9| 9| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
100 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 1 4.0|
Endometrium, Fibrosis | | 1 2.0|
Endometrium, Hyperplasia, Cystic | | 21 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Femoral, Myelofibrosis, Multifocal | | 2 2.0|
Femoral, Necrosis, Caseous | | 1 4.0|
Sternal, Myelofibrosis, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Renal, Infiltration Cellular, | | |
Polymorphonuclear | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 48 |
Infiltration Cellular, | | |
Polymorphonuclear | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 7 |
Hematopoietic Cell Proliferation | | 1 2.0|
Infiltration Cellular, | | |
Polymorphonuclear | | 3 2.7|
Sinus, Ectasia | | 2 3.5|
__________________________________________________________________________|____________|
Spleen | | 50 |
Amyloid Deposition | | 2 1.5|
Depletion Lymphoid | | 1 3.0|
Hematopoietic Cell Proliferation | | 30 3.2|
__________________________________________________________________________|____________|
Thymus | | 33 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 39 |
Cervical, Atypia Cytologic | | 1 3.0|
Inguinal, Hyperplasia, Cystic | | 9 2.1|
Inguinal, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Skin | | 50 |
Abscess | | 1 3.0|
Acanthosis | | 4 1.3|
Hyperkeratosis | | 2 1.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Necrotizing | | 6 2.8|
Back, Acanthosis | | 4 1.5|
Back, Hyperkeratosis | | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 8| 9| 9| 8| 8| 9| 9| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
100 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Back, Inflammation, Necrotizing | | 1 3.0|
Scapula, Abscess | | 2 3.0|
Scapula, Acanthosis | | 36 1.8|
Scapula, Hyperkeratosis | | 20 1.2|
Scapula, Inflammation, Necrotizing | | 16 2.6|
Subcutaneous Tissue, Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Mineralization, Multifocal | | 24 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Hemorrhage, Multifocal | | 2 2.0|
Inflammation, Focal, Suppurative | | 2 2.5|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Artery, Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Glands, Inflammation, Acute | | 1 2.0|
Nerve, Nares, Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 45 |
Hyperplasia, Nodular | | 1 1.0|
Inflammation, Necrotizing | | 1 1.0|
Inflammation, Subacute | | 3 2.7|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Inflammation, Multifocal, Subacute | | 2 2.0|
Inflammation, Necrotizing | | 1 4.0|
Renal Tubule, Bacterium | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 8| 9| 9| 8| 8| 9| 9| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
100 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Casts Protein, | | |
Multifocal | | 1 2.0|
Renal Tubule, Mineralization, | | |
Multifocal | | 1 1.0|
Renal Tubule, Necrosis, Coagulative, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
Inflammation, Acute | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 7| 2| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5|
DAY ON TEST | 2| 1| 8| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7|
| 9| 5| 7| 9| 9| 9| 9| 9| 9| 9| 4| 0| 8| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Cytomegaly, Multifocal | 2 |
Inclusion Body Intracytoplasmic | 2 |
Inflammation, Chronic Active, | |
Multifocal | 1 |
Necrosis, Coagulative, Multifocal | 2|
Thrombosis | X X X X|
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 1 |
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Hyperkeratosis | 1 |
Ulcer | 1 1 1 |
Lamina Propria, Infiltration | |
Cellular, Focal, Histiocyte | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | |
Serosa, Granuloma | |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Molar, Abscess | |
Pulp, Molar, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Coronary Artery, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 7| 2| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5|
DAY ON TEST | 2| 1| 8| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7|
| 9| 5| 7| 9| 9| 9| 9| 9| 9| 9| 4| 0| 8| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Chronic | 1 |
Myocardium, Inflammation, Chronic, | |
Focal | |
Myocardium, Mineralization, | |
Multifocal | |
Pericardium, Ectopic Thyroid | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 3 2 2 3 2 3 2 2 2 2 2 2 2 2 2 3 2 3 2 3 3 2 2 2 1|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 2 2 1 1 2 1 1 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 1 1 2 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + M + + + + + I + +|
__________________________________________________________________________|
Pituitary Gland | M M + + + + + + + + + + + + + + M + + + + + + + M|
Pars Distalis, Hyperplasia, Nodular | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Hyperplasia, Nodular | 1 3 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + |
Abscess | 4 3 3 3 |
Inflammation, Chronic | 3 |
Duct, Dilatation | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2|
__________________________________________________________________________|
Seminal Vesicle | |
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Polychromasia | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Thrombosis | |
__________________________________________________________________________|
Lymph Node | + + + + + M + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 7| 2| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5|
DAY ON TEST | 2| 1| 8| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7|
| 9| 5| 7| 9| 9| 9| 9| 9| 9| 9| 4| 0| 8| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 |
Infiltration Cellular, | |
Polymorphonuclear | 1 |
Infiltration Cellular, Histiocyte | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | |
Hematopoietic Cell Proliferation | |
Infiltration Cellular, | |
Polymorphonuclear | |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + I + + + + + + +|
Depletion Lymphoid | 3 |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 2 2 |
Thrombosis | |
Subcapsular, Infiltration Cellular, | |
Multifocal, Histiocyte | 2 |
__________________________________________________________________________|
Thymus | + M + I M + + + M + + + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M + M M M M M M + M M M M M M M + M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Inflammation, Chronic | 1 |
Back, Parasite Metazoan | |
Scapula, Acanthosis | 1 |
Scapula, Hyperkeratosis | |
Scapula, Inflammation, Necrotizing | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Proliferation | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Multifocal | |
Mineralization, Multifocal | 1 1 1 1 1 1 1 1 1|
Hypothalamus, Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Diffuse | 3 2 |
Hemorrhage, Focal | |
Hemorrhage, Multifocal | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 7| 2| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5|
DAY ON TEST | 2| 1| 8| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7|
| 9| 5| 7| 9| 9| 9| 9| 9| 9| 9| 4| 0| 8| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Focal, Suppurative | 1 |
Bronchiole, Edema, Diffuse | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + M + + + M + + + + + + M + + + M + + M + + + +|
Hyperplasia, Nodular | |
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
Hemorrhage, Multifocal | |
Hydronephrosis | |
Inflammation, Necrotizing | 2|
Fat, Infiltration Cellular, Focal, | |
Histiocyte | 2 |
Glomerulus, Inflammation, | |
Proliferative | 3 |
Renal Tubule, Bacterium | X|
Renal Tubule, Casts Protein, | |
Multifocal | 3 |
Renal Tubule, Cyst | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 4| 7| 7| 7| 7| 7| 0| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 0| 3| 3|
| 1| 1| 1| 1| 1| 2| 1| 9| 1| 1| 1| 1| 2| 2| 2| 5| 5| 2| 2| 2| 2| 2| 4| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + M + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Cytomegaly, Multifocal | 1 |
Inclusion Body Intracytoplasmic | |
Inflammation, Chronic Active, | |
Multifocal | |
Necrosis, Coagulative, Multifocal | |
Thrombosis | X X |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia, Nodular | |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Hyperkeratosis | 1 |
Ulcer | |
Lamina Propria, Infiltration | |
Cellular, Focal, Histiocyte | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | 2 |
Serosa, Granuloma | 3 |
__________________________________________________________________________|
Tooth | + + +|
Peridontal Tissue, Molar, Abscess | 3 |
Pulp, Molar, Inflammation, Chronic | 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Coronary Artery, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 4| 7| 7| 7| 7| 7| 0| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 0| 3| 3|
| 1| 1| 1| 1| 1| 2| 1| 9| 1| 1| 1| 1| 2| 2| 2| 5| 5| 2| 2| 2| 2| 2| 4| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Chronic | |
Myocardium, Inflammation, Chronic, | |
Focal | 1 |
Myocardium, Mineralization, | |
Multifocal | 1 |
Pericardium, Ectopic Thyroid | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 3 2 2 2 1 2 2 2 2 2 2 2 2 2 2 3 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 2 1 2 1 2 2 2 1 2 3 3 2 3 2 3 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia | 1 1 1 1 2 1 2 2 1 2 1 1 2 2|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + M + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + I + + + I + + + + + + + M +|
Pars Distalis, Hyperplasia, Nodular | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Hyperplasia, Nodular | 1 2 2 1 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + |
Abscess | 3 3 |
Inflammation, Chronic | |
Duct, Dilatation | 4 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | +|
Dilatation | 4|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Polychromasia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + I + + + + + + + + + + + + + +|
Femoral, Thrombosis | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 4| 7| 7| 7| 7| 7| 0| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 0| 3| 3|
| 1| 1| 1| 1| 1| 2| 1| 9| 1| 1| 1| 1| 2| 2| 2| 5| 5| 2| 2| 2| 2| 2| 4| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hematopoietic Cell Proliferation | |
Infiltration Cellular, | |
Polymorphonuclear | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
Hematopoietic Cell Proliferation | 2 |
Infiltration Cellular, | |
Polymorphonuclear | 1 |
Sinus, Ectasia | 4 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 3 3 |
Fibrosis, Focal | 3|
Hematopoietic Cell Proliferation | |
Thrombosis | X |
Subcapsular, Infiltration Cellular, | |
Multifocal, Histiocyte | |
__________________________________________________________________________|
Thymus | + + M + + M + + M + + + + + + + M + + + + + I + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M M M M + + M M M M M M M M M M M M M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Inflammation, Chronic | |
Back, Parasite Metazoan | X |
Scapula, Acanthosis | |
Scapula, Hyperkeratosis | 1 |
Scapula, Inflammation, Necrotizing | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Proliferation | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Multifocal | 1 |
Mineralization, Multifocal | 1 1 1 2 1 1 1 1 1 1 1 2|
Hypothalamus, Compression | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Diffuse | 3 |
Hemorrhage, Focal | 1 1 |
Hemorrhage, Multifocal | 2 2 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 0| 4| 7| 7| 7| 7| 7| 0| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 0| 3| 3|
| 1| 1| 1| 1| 1| 2| 1| 9| 1| 1| 1| 1| 2| 2| 2| 5| 5| 2| 2| 2| 2| 2| 4| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Focal, Suppurative | |
Bronchiole, Edema, Diffuse | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | M + M + + M + M + + + + M I + + + + + + + + + + +|
Hyperplasia, Nodular | 2 3 |
Inflammation, Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Hemorrhage, Multifocal | 1 |
Hydronephrosis | 4 |
Inflammation, Necrotizing | |
Fat, Infiltration Cellular, Focal, | |
Histiocyte | |
Glomerulus, Inflammation, | |
Proliferative | |
Renal Tubule, Bacterium | |
Renal Tubule, Casts Protein, | |
Multifocal | |
Renal Tubule, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | X |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 8| 9| 8| 9| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Gallbladder | | 47 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 50 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 50 |
__________________________________________________________________________|____________|
Liver | | 50 |
Cyst | | 3 |
Cytomegaly, Multifocal | | 2 1.5|
Inclusion Body Intracytoplasmic | | 1 2.0|
Inflammation, Chronic Active, | | |
Multifocal | | 1 1.0|
Necrosis, Coagulative, Multifocal | | 1 2.0|
Thrombosis | | 6 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | | 49 |
Hyperplasia, Nodular | | 1 1.0|
Acinus, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
Artery, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Acanthosis | | 2 1.0|
Hyperkeratosis | | 2 1.0|
Ulcer | | 3 1.0|
Lamina Propria, Infiltration | | |
Cellular, Focal, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Inflammation, Necrotizing | | 1 2.0|
Serosa, Granuloma | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 4 |
Peridontal Tissue, Molar, Abscess | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 8| 9| 8| 9| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Pulp, Molar, Inflammation, Chronic | | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Coronary Artery, Inflammation, | | |
Chronic | | 1 1.0|
Myocardium, Inflammation, Chronic, | | |
Focal | | 1 1.0|
Myocardium, Mineralization, | | |
Multifocal | | 1 1.0|
Pericardium, Ectopic Thyroid | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
Capsule, Hyperplasia | | 44 2.2|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Hyperplasia, Nodular | | 27 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 48 |
Hyperplasia | | 22 1.4|
__________________________________________________________________________|____________|
Parathyroid Gland | | 44 |
__________________________________________________________________________|____________|
Pituitary Gland | | 43 |
Pars Distalis, Hyperplasia, Nodular | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 49 |
Follicle, Hyperplasia, Nodular | | 12 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 50 |
__________________________________________________________________________|____________|
Preputial Gland | | 10 |
Abscess | | 6 3.2|
Inflammation, Chronic | | 1 3.0|
Duct, Dilatation | | 4 3.5|
__________________________________________________________________________|____________|
Prostate | | 50 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 8| 9| 8| 9| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Testes | | 50 |
Infarct | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
Polychromasia | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | | 49 |
Femoral, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 49 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 48 |
Hematopoietic Cell Proliferation | | 1 1.0|
Infiltration Cellular, | | |
Polymorphonuclear | | 1 1.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 5 |
Hematopoietic Cell Proliferation | | 1 2.0|
Infiltration Cellular, | | |
Polymorphonuclear | | 1 1.0|
Sinus, Ectasia | | 2 4.0|
__________________________________________________________________________|____________|
Spleen | | 49 |
Depletion Lymphoid | | 4 3.0|
Fibrosis, Focal | | 1 3.0|
Hematopoietic Cell Proliferation | | 2 2.0|
Thrombosis | | 1 |
Subcapsular, Infiltration Cellular, | | |
Multifocal, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | | 40 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 9 |
__________________________________________________________________________|____________|
Skin | | 50 |
Abscess | | 1 4.0|
Inflammation, Chronic | | 1 1.0|
Back, Parasite Metazoan | | 1 |
Scapula, Acanthosis | | 1 1.0|
Scapula, Hyperkeratosis | | 1 1.0|
Scapula, Inflammation, Necrotizing | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 8| 9| 8| 9| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Cranium, Proliferation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Hemorrhage, Multifocal | | 1 1.0|
Mineralization, Multifocal | | 21 1.1|
Hypothalamus, Compression | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion, Diffuse | | 3 2.7|
Hemorrhage, Focal | | 2 1.0|
Hemorrhage, Multifocal | | 2 2.0|
Inflammation, Focal, Suppurative | | 1 1.0|
Bronchiole, Edema, Diffuse | | 1 2.0|
__________________________________________________________________________|____________|
Nose | | 50 |
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 39 |
Hyperplasia, Nodular | | 2 2.5|
Inflammation, Chronic, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Ectopic Tissue | | 1 |
Hemorrhage, Multifocal | | 1 1.0|
Hydronephrosis | | 1 4.0|
Inflammation, Necrotizing | | 1 2.0|
Fat, Infiltration Cellular, Focal, | | |
Histiocyte | | 1 2.0|
Glomerulus, Inflammation, | | |
Proliferative | | 1 3.0|
Renal Tubule, Bacterium | | 1 |
Renal Tubule, Casts Protein, | | |
Multifocal | | 1 3.0|
Renal Tubule, Cyst | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 8| 9| 8| 9| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
Thrombosis | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 0| 6| 7| 6| 5| 7| 7| 7| 6| 7| 5| 3|
DAY ON TEST | 2| 2| 2| 2| 2| 9| 1| 2| 2| 3| 3| 3| 3| 3| 5| 3| 9| 9| 3| 3| 3| 5| 3| 2| 8|
| 9| 9| 9| 9| 9| 4| 4| 9| 9| 0| 0| 0| 0| 0| 4| 0| 8| 0| 0| 0| 0| 3| 0| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
25 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + M +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Inclusion Body Intracytoplasmic | |
Necrosis, Coagulative, Focal | 3 |
Necrosis, Coagulative, Multifocal | 2 |
Thrombosis | X X |
Vein, Dilatation, Focal | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + |
Peridontal Tissue, Incisor, | |
Inflammation, Chronic | 2 |
Peridontal Tissue, Molar, | |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | +|
Renal Artery, Inflammation, Chronic | 3|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Thrombosis | X|
Atrium Left, Dilatation | |
Atrium Left, Thrombosis | |
Coronary Artery, Inflammation, | |
Chronic | 2 2|
Myocardium, Inflammation, Chronic, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 0| 6| 7| 6| 5| 7| 7| 7| 6| 7| 5| 3|
DAY ON TEST | 2| 2| 2| 2| 2| 9| 1| 2| 2| 3| 3| 3| 3| 3| 5| 3| 9| 9| 3| 3| 3| 5| 3| 2| 8|
| 9| 9| 9| 9| 9| 4| 4| 9| 9| 0| 0| 0| 0| 0| 4| 0| 8| 0| 0| 0| 0| 3| 0| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
25 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Myocardium, Inflammation, Focal, | |
Subacute | 1 |
Valve, Inflammation, Subacute | |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 3 2 2 2 3 2 1 1 3 2 2 1 1 2 3 2 1 2 1 1|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 2 2 1 3 3 3 2 2 2 2 2 2 2 2 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | |
Hyperplasia | 1 1 |
__________________________________________________________________________|
Parathyroid Gland | I + + + + + + + + + + + + M + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | |
Pars Distalis, Hyperplasia, Nodular | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | |
Inflammation, Chronic | |
Follicle, Hyperplasia, Nodular | 2 2 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Preputial Gland | |
Abscess | |
Inflammation, Chronic | |
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + M + + + + + + + + M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 0| 6| 7| 6| 5| 7| 7| 7| 6| 7| 5| 3|
DAY ON TEST | 2| 2| 2| 2| 2| 9| 1| 2| 2| 3| 3| 3| 3| 3| 5| 3| 9| 9| 3| 3| 3| 5| 3| 2| 8|
| 9| 9| 9| 9| 9| 4| 4| 9| 9| 0| 0| 0| 0| 0| 4| 0| 8| 0| 0| 0| 0| 3| 0| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
25 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 1 |
Infiltration Cellular, | |
Polymorphonuclear | 2 |
Sinus, Ectasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Depletion Lymphoid | 4 |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 2 4 2 1 1 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M M + + M + + M M + + +|
Ectopic Parathyroid Gland | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M M M M M M M M + M M M M M + + M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 1 |
Edema | |
Hyperkeratosis | 1 |
Back, Acanthosis | 1 2 2 1 |
Back, Hyperkeratosis | 1 |
Scapula, Acanthosis | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 3 |
Scapula, Hyperkeratosis | 1 1 1 1 2 |
Scapula, Inflammation, Chronic | |
Scapula, Inflammation, Necrotizing | 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Interstitium, Inflammation, Chronic | 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + M + + + + M + + M + + + + + + + + + + +|
Hyperplasia, Nodular | 2 |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 0| 6| 7| 6| 5| 7| 7| 7| 6| 7| 5| 3|
DAY ON TEST | 2| 2| 2| 2| 2| 9| 1| 2| 2| 3| 3| 3| 3| 3| 5| 3| 9| 9| 3| 3| 3| 5| 3| 2| 8|
| 9| 9| 9| 9| 9| 4| 4| 9| 9| 0| 0| 0| 0| 0| 4| 0| 8| 0| 0| 0| 0| 3| 0| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
25 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 7| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 3| 0| 3|
| 3| 0| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1| 1| 2| 2| 2| 0| 2| 2| 1| 2| 2| 2| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
25 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + M + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inclusion Body Intracytoplasmic | 2 |
Necrosis, Coagulative, Focal | |
Necrosis, Coagulative, Multifocal | 3 2 2 |
Thrombosis | |
Vein, Dilatation, Focal | 1 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Incisor, | |
Inflammation, Chronic | 3 |
Peridontal Tissue, Molar, | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Renal Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Thrombosis | |
Atrium Left, Dilatation | 4 |
Atrium Left, Thrombosis | X |
Coronary Artery, Inflammation, | |
Chronic | |
Myocardium, Inflammation, Chronic, | |
Multifocal | 1 |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 7| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 3| 0| 3|
| 3| 0| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1| 1| 2| 2| 2| 0| 2| 2| 1| 2| 2| 2| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
25 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Myocardium, Inflammation, Focal, | |
Subacute | |
Valve, Inflammation, Subacute | 1 |
Valve, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 3 2 2 2 3 2 2 3 2 2 2 3 2 3 2 2 3 3 2 3 3 3|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 2 2 2 2 1 2 1 1 3 2 2 2 2 3|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 3 |
Hyperplasia | 1 2 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + M + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M M M + + + +|
Pars Distalis, Hyperplasia | 3 |
Pars Distalis, Hyperplasia, Nodular | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 2 |
Inflammation, Chronic | 3 |
Follicle, Hyperplasia, Nodular | 2 2 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + |
Abscess | 3 3 3 |
Inflammation, Chronic | 1 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 7| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 3| 0| 3|
| 3| 0| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1| 1| 2| 2| 2| 0| 2| 2| 1| 2| 2| 2| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
25 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | |
Infiltration Cellular, | |
Polymorphonuclear | |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Depletion Lymphoid | 4 |
Fibrosis, Focal | 1 |
Hematopoietic Cell Proliferation | 4 |
__________________________________________________________________________|
Thymus | + + + + M + + + I + + + + + + + + + + + + + + M +|
Ectopic Parathyroid Gland | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + + M + M M M + M M M + M M M + M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 |
Edema | 3 |
Hyperkeratosis | |
Back, Acanthosis | 2 1 |
Back, Hyperkeratosis | |
Scapula, Acanthosis | 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 3 1 1 1|
Scapula, Hyperkeratosis | 2 1 1 1 1 1 1|
Scapula, Inflammation, Chronic | 1 |
Scapula, Inflammation, Necrotizing | 1 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
Interstitium, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + M + + + + M + M + + + + + +|
Hyperplasia, Nodular | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 7| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 2| 3| 3| 3| 0| 3|
| 3| 0| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1| 1| 2| 2| 2| 0| 2| 2| 1| 2| 2| 2| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
25 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 1 |
__________________________________________________________________________|
Urinary Bladder | M + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 8| 8| 9| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
25 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Gallbladder | | 49 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 48 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 50 |
__________________________________________________________________________|____________|
Liver | | 50 |
Cyst | | 3 |
Inclusion Body Intracytoplasmic | | 1 2.0|
Necrosis, Coagulative, Focal | | 1 3.0|
Necrosis, Coagulative, Multifocal | | 4 2.3|
Thrombosis | | 2 |
Vein, Dilatation, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 50 |
Acinus, Atrophy | | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
__________________________________________________________________________|____________|
Tooth | | 3 |
Peridontal Tissue, Incisor, | | |
Inflammation, Chronic | | 2 2.5|
Peridontal Tissue, Molar, | | |
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Renal Artery, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Heart | | 50 |
Artery, Thrombosis | | 1 |
Atrium Left, Dilatation | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 8| 8| 9| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
25 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Atrium Left, Thrombosis | | 1 |
Coronary Artery, Inflammation, | | |
Chronic | | 2 2.0|
Myocardium, Inflammation, Chronic, | | |
Multifocal | | 1 1.0|
Myocardium, Inflammation, Focal, | | |
Subacute | | 1 1.0|
Valve, Inflammation, Subacute | | 1 1.0|
Valve, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
Capsule, Hyperplasia | | 42 2.2|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 49 |
Hyperplasia, Nodular | | 30 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
Cytoplasmic Alteration | | 1 3.0|
Hyperplasia | | 5 1.6|
__________________________________________________________________________|____________|
Parathyroid Gland | | 44 |
__________________________________________________________________________|____________|
Pituitary Gland | | 47 |
Pars Distalis, Hyperplasia | | 1 3.0|
Pars Distalis, Hyperplasia, Nodular | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Hyperplasia, Nodular | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
Follicle, Hyperplasia, Nodular | | 9 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 50 |
Granuloma Sperm | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | | 4 |
Abscess | | 3 3.0|
Inflammation, Chronic | | 1 1.0|
Duct, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 8| 8| 9| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
25 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Testes | | 50 |
Inflammation, Chronic, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
__________________________________________________________________________|____________|
Lymph Node | | 49 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 46 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 8 |
Hematopoietic Cell Proliferation | | 1 1.0|
Infiltration Cellular, | | |
Polymorphonuclear | | 1 2.0|
Sinus, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Amyloid Deposition | | 1 2.0|
Depletion Lymphoid | | 2 4.0|
Fibrosis, Focal | | 1 1.0|
Hematopoietic Cell Proliferation | | 7 2.4|
__________________________________________________________________________|____________|
Thymus | | 42 |
Ectopic Parathyroid Gland | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 11 |
__________________________________________________________________________|____________|
Skin | | 50 |
Acanthosis | | 5 1.0|
Edema | | 1 3.0|
Hyperkeratosis | | 1 1.0|
Back, Acanthosis | | 6 1.5|
Back, Hyperkeratosis | | 1 1.0|
Scapula, Acanthosis | | 35 1.2|
Scapula, Hyperkeratosis | | 12 1.2|
Scapula, Inflammation, Chronic | | 1 1.0|
Scapula, Inflammation, Necrotizing | | 4 1.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 8| 8| 9| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
25 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Mineralization, Multifocal | | 30 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
Interstitium, Inflammation, Chronic | | 2 1.0|
__________________________________________________________________________|____________|
Nose | | 50 |
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 42 |
Hyperplasia, Nodular | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Infarct | | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 5| 6| 6| 4| 6| 7| 7| 7| 6| 6| 4| 5| 7| 6| 6| 6| 6| 6| 0| 6| 7| 6| 6| 6| 0|
DAY ON TEST | 6| 8| 9| 1| 5| 1| 2| 2| 8| 3| 3| 2| 1| 4| 0| 7| 8| 9| 0| 7| 0| 9| 8| 1| 0|
| 4| 7| 6| 1| 2| 1| 9| 6| 9| 5| 6| 7| 1| 3| 4| 8| 7| 5| 4| 2| 7| 8| 8| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Basophilic Focus | |
Cyst | X |
Inclusion Body Intracytoplasmic | 2 |
Inflammation, Chronic Active, | |
Multifocal | 2 2 3 |
Necrosis, Coagulative, Focal | 2 |
Necrosis, Coagulative, Multifocal | 2 4 |
Thrombosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Multifocal, Subacute | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Bacterium | |
Aorta, Inflammation, Chronic Active | |
Aorta, Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Mineralization, | |
Multifocal | |
Valve, Bacterium | |
Valve, Inflammation, Subacute | |
Valve, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 3 1 1 2 2 2 1 1 2 2 1 1 1 3 2 3 1 |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 5| 6| 6| 4| 6| 7| 7| 7| 6| 6| 4| 5| 7| 6| 6| 6| 6| 6| 0| 6| 7| 6| 6| 6| 0|
DAY ON TEST | 6| 8| 9| 1| 5| 1| 2| 2| 8| 3| 3| 2| 1| 4| 0| 7| 8| 9| 0| 7| 0| 9| 8| 1| 0|
| 4| 7| 6| 1| 2| 1| 9| 6| 9| 5| 6| 7| 1| 3| 4| 8| 7| 5| 4| 2| 7| 8| 8| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Nodular | 2 |
Hyperplasia, Nodular | 1 |
Necrosis, Liquifactive | 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + + + + + + + +|
Necrosis, Liquifactive | 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + M + + M M + + + M +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 1 |
Follicle, Hyperplasia, Nodular | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 2 2 |
__________________________________________________________________________|
Preputial Gland | + + |
Abscess | 2 |
Inflammation, Chronic | |
Duct, Dilatation | 3 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + M + + + + + + + + + + + + + M + + + + + M|
Bronchial, Infiltration Cellular, | |
Polymorphonuclear | |
Mediastinal, Infiltration Cellular, | |
Polymorphonuclear | |
Renal, Hyperplasia, Plasma Cell | 3 |
Renal, Infiltration Cellular, | |
Polymorphonuclear | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + M + + + + + M|
Infiltration Cellular, | |
Polymorphonuclear | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Hematopoietic Cell Proliferation | 2 |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 5| 6| 6| 4| 6| 7| 7| 7| 6| 6| 4| 5| 7| 6| 6| 6| 6| 6| 0| 6| 7| 6| 6| 6| 0|
DAY ON TEST | 6| 8| 9| 1| 5| 1| 2| 2| 8| 3| 3| 2| 1| 4| 0| 7| 8| 9| 0| 7| 0| 9| 8| 1| 0|
| 4| 7| 6| 1| 2| 1| 9| 6| 9| 5| 6| 7| 1| 3| 4| 8| 7| 5| 4| 2| 7| 8| 8| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, | |
Polymorphonuclear | 2 3 1 |
Sinus, Ectasia | 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 4 4 4|
Fibrosis | |
Hematopoietic Cell Proliferation | 4 3 4 4 3 3 4 4 4 2 3 4 3 4 1 3 4 3 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Thymus | M + I + + M + M M + M + M M M + + + + M M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Acanthosis | 2 1 |
Edema | 3 |
Hyperkeratosis | 1 1 |
Inflammation, Acute | |
Inflammation, Necrotizing | 4 4 3 |
Back, Acanthosis | 2 1 2 2 |
Back, Hyperkeratosis | 1 1 1 |
Scapula, Acanthosis | 2 2 3 1 2 2 3 2 3 2 2 2 2 1 2 2 2 2 3 3 |
Scapula, Hyperkeratosis | 1 1 1 1 1 1 1 |
Scapula, Inflammation, Chronic Active| 2 |
Scapula, Inflammation, Necrotizing | 3 2 4 2 1 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 1 1 |
Hemorrhage, Multifocal | 1 |
Thrombosis | X |
Interstitium, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 5| 6| 6| 4| 6| 7| 7| 7| 6| 6| 4| 5| 7| 6| 6| 6| 6| 6| 0| 6| 7| 6| 6| 6| 0|
DAY ON TEST | 6| 8| 9| 1| 5| 1| 2| 2| 8| 3| 3| 2| 1| 4| 0| 7| 8| 9| 0| 7| 0| 9| 8| 1| 0|
| 4| 7| 6| 1| 2| 1| 9| 6| 9| 5| 6| 7| 1| 3| 4| 8| 7| 5| 4| 2| 7| 8| 8| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 3 |
Inflammation, Subacute | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Inflammation, Multifocal, Subacute | 3 |
Inflammation, Necrotizing | |
Renal Tubule, Bacterium | |
Renal Tubule, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 6| 5| 0| 6| 6| 0| 6| 5| 6| 7| 7| 7| 6| 7| 5| 7| 5| 6| 6| 5| 4| 4| 0| 2| 4|
DAY ON TEST | 1| 4| 0| 8| 2| 4| 2| 2| 2| 0| 2| 2| 2| 2| 9| 2| 7| 2| 8| 2| 5| 5| 3| 4| 5|
| 4| 3| 4| 4| 5| 2| 5| 0| 5| 8| 3| 9| 5| 9| 4| 9| 2| 5| 7| 3| 9| 8| 0| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
50 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + M + M + M + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + M + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + |
Amyloid Deposition | 3 |
Basophilic Focus | 3 3 |
Cyst | X X X |
Inclusion Body Intracytoplasmic | |
Inflammation, Chronic Active, | |
Multifocal | 3 3 2 |
Necrosis, Coagulative, Focal | |
Necrosis, Coagulative, Multifocal | 4 1 2 |
Thrombosis | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + |
Acinus, Atrophy | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Multifocal, Subacute | 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Bacterium | X |
Aorta, Inflammation, Chronic Active | 3 |
Aorta, Thrombosis | X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + |
Myocardium, Mineralization, | |
Multifocal | 2 |
Valve, Bacterium | X |
Valve, Inflammation, Subacute | 2 |
Valve, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + |
Capsule, Hyperplasia | 1 2 1 2 1 1 1 1 1 4 3 3 2 3 1 1 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 6| 5| 0| 6| 6| 0| 6| 5| 6| 7| 7| 7| 6| 7| 5| 7| 5| 6| 6| 5| 4| 4| 0| 2| 4|
DAY ON TEST | 1| 4| 0| 8| 2| 4| 2| 2| 2| 0| 2| 2| 2| 2| 9| 2| 7| 2| 8| 2| 5| 5| 3| 4| 5|
| 4| 3| 4| 4| 5| 2| 5| 0| 5| 8| 3| 9| 5| 9| 4| 9| 2| 5| 7| 3| 9| 8| 0| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
50 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Focal, Nodular | |
Hyperplasia, Nodular | 2 2 1 1 |
Necrosis, Liquifactive | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + |
Necrosis, Liquifactive | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + M + + + + M + + + + + + + + + + M |
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M M M + M + + + + + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + M + M |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + M |
Hyperplasia, Nodular | |
Follicle, Hyperplasia, Nodular | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Subacute | 1 3 2 |
__________________________________________________________________________|
Preputial Gland | + + + |
Abscess | 4 |
Inflammation, Chronic | |
Duct, Dilatation | 4 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 3 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + |
Seminiferous Tubule, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + M + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + M + + + + + + + + + M + |
Bronchial, Infiltration Cellular, | |
Polymorphonuclear | 3 |
Mediastinal, Infiltration Cellular, | |
Polymorphonuclear | 3 3 |
Renal, Hyperplasia, Plasma Cell | |
Renal, Infiltration Cellular, | |
Polymorphonuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + M + + M + |
Infiltration Cellular, | |
Polymorphonuclear | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + |
Hematopoietic Cell Proliferation | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 6| 5| 0| 6| 6| 0| 6| 5| 6| 7| 7| 7| 6| 7| 5| 7| 5| 6| 6| 5| 4| 4| 0| 2| 4|
DAY ON TEST | 1| 4| 0| 8| 2| 4| 2| 2| 2| 0| 2| 2| 2| 2| 9| 2| 7| 2| 8| 2| 5| 5| 3| 4| 5|
| 4| 3| 4| 4| 5| 2| 5| 0| 5| 8| 3| 9| 5| 9| 4| 9| 2| 5| 7| 3| 9| 8| 0| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
50 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, | |
Polymorphonuclear | 3 3 3 2 2 3 3 |
Sinus, Ectasia | 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + |
Depletion Lymphoid | 2 4 |
Fibrosis | 1 |
Hematopoietic Cell Proliferation | 3 4 3 4 3 3 4 2 3 3 3 4 |
Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Thymus | + M + M M + M + + + M + + + M + M M + M M + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M M M M M M M M + M M + M M M + M + M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + |
Abscess | 3 |
Acanthosis | 2 1 3 |
Edema | |
Hyperkeratosis | |
Inflammation, Acute | 3 |
Inflammation, Necrotizing | 1 4 4 |
Back, Acanthosis | 2 2 |
Back, Hyperkeratosis | 1 |
Scapula, Acanthosis | 2 1 2 2 2 2 2 2 1 3 3 2 2 2 3 2 |
Scapula, Hyperkeratosis | 1 1 1 1 1 1 |
Scapula, Inflammation, Chronic Active| |
Scapula, Inflammation, Necrotizing | 1 3 3 3 4 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + M + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + |
Mineralization, Multifocal | 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + |
Hemorrhage, Focal | |
Hemorrhage, Multifocal | 1 |
Thrombosis | |
Interstitium, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + M |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 6| 5| 0| 6| 6| 0| 6| 5| 6| 7| 7| 7| 6| 7| 5| 7| 5| 6| 6| 5| 4| 4| 0| 2| 4|
DAY ON TEST | 1| 4| 0| 8| 2| 4| 2| 2| 2| 0| 2| 2| 2| 2| 9| 2| 7| 2| 8| 2| 5| 5| 3| 4| 5|
| 4| 3| 4| 4| 5| 2| 5| 0| 5| 8| 3| 9| 5| 9| 4| 9| 2| 5| 7| 3| 9| 8| 0| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
50 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + M + M + + + + + |
Hyperplasia, Nodular | |
Inflammation, Subacute | 2 2 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + |
Infarct | 3 |
Inflammation, Multifocal, Subacute | 3 |
Inflammation, Necrotizing | 3 |
Renal Tubule, Bacterium | X |
Renal Tubule, Cyst | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + |
Ectasia | |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 0| 4| 2| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 0| 5| 1| 5| 5| 5| 5| 5| 5| | |
| 5| 4| 9| 8| 8| 9| 8| 9| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + | 46 |
__________________________________________________________________________|____________|
Intestine Large | + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 49 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + M + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + M | 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + | 50 |
Amyloid Deposition | | 1 3.0|
Basophilic Focus | | 2 3.0|
Cyst | | 4 |
Inclusion Body Intracytoplasmic | 2 | 2 2.0|
Inflammation, Chronic Active, | | |
Multifocal | | 6 2.5|
Necrosis, Coagulative, Focal | | 1 2.0|
Necrosis, Coagulative, Multifocal | | 5 2.6|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + | 50 |
Acinus, Atrophy | | 2 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + | 50 |
Inflammation, Multifocal, Subacute | | 3 2.0|
__________________________________________________________________________|____________|
Stomach | + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Bacterium | | 1 |
Aorta, Inflammation, Chronic Active | | 1 3.0|
Aorta, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Heart | + + + | 50 |
Myocardium, Mineralization, | | |
Multifocal | | 1 2.0|
Valve, Bacterium | X | 2 |
Valve, Inflammation, Subacute | 4 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 0| 4| 2| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 0| 5| 1| 5| 5| 5| 5| 5| 5| | |
| 5| 4| 9| 8| 8| 9| 8| 9| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Valve, Thrombosis | X | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + | 49 |
Capsule, Hyperplasia | 2 1 | 38 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + | 49 |
Hyperplasia, Focal, Nodular | | 1 2.0|
Hyperplasia, Nodular | | 5 1.4|
Necrosis, Liquifactive | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + | 48 |
Necrosis, Liquifactive | | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 47 |
Hyperplasia | | 3 1.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + | 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 42 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 49 |
Hyperplasia, Nodular | | 1 1.0|
Follicle, Hyperplasia, Nodular | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + | 50 |
Inflammation, Subacute | | 6 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + | 6 |
Abscess | | 2 3.0|
Inflammation, Chronic | 3 | 1 3.0|
Duct, Dilatation | 3 | 5 3.2|
__________________________________________________________________________|____________|
Prostate | + + + | 50 |
Inflammation, Chronic Active | | 5 2.4|
__________________________________________________________________________|____________|
Testes | + + + | 50 |
Seminiferous Tubule, Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 45 |
Bronchial, Infiltration Cellular, | | |
Polymorphonuclear | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 0| 4| 2| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 0| 5| 1| 5| 5| 5| 5| 5| 5| | |
| 5| 4| 9| 8| 8| 9| 8| 9| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Infiltration Cellular, | | |
Polymorphonuclear | | 2 3.0|
Renal, Hyperplasia, Plasma Cell | | 1 3.0|
Renal, Infiltration Cellular, | | |
Polymorphonuclear | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 43 |
Infiltration Cellular, | | |
Polymorphonuclear | | 3 1.7|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 13 |
Hematopoietic Cell Proliferation | | 1 2.0|
Infiltration Cellular, | | |
Polymorphonuclear | | 10 2.5|
Sinus, Ectasia | | 4 3.0|
__________________________________________________________________________|____________|
Spleen | + + + | 50 |
Depletion Lymphoid | 4 4 | 8 3.6|
Fibrosis | | 1 1.0|
Hematopoietic Cell Proliferation | 1 | 31 3.2|
Necrosis, Coagulative | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M M + | 27 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M | 5 |
__________________________________________________________________________|____________|
Skin | + + + | 50 |
Abscess | | 1 3.0|
Acanthosis | 1 | 6 1.7|
Edema | | 1 3.0|
Hyperkeratosis | | 2 1.0|
Inflammation, Acute | | 1 3.0|
Inflammation, Necrotizing | | 6 3.3|
Back, Acanthosis | | 6 1.8|
Back, Hyperkeratosis | | 4 1.0|
Scapula, Acanthosis | 1 1 | 38 2.1|
Scapula, Hyperkeratosis | 1 | 14 1.0|
Scapula, Inflammation, Chronic Active| | 1 2.0|
Scapula, Inflammation, Necrotizing | | 12 2.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 0| 4| 2| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 3| 0| 5| 1| 5| 5| 5| 5| 5| 5| | |
| 5| 4| 9| 8| 8| 9| 8| 9| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 50 |
Mineralization, Multifocal | | 25 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + | 50 |
Hemorrhage, Focal | | 2 1.0|
Hemorrhage, Multifocal | | 2 1.0|
Thrombosis | | 1 |
Interstitium, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 48 |
Hyperplasia, Nodular | | 1 3.0|
Inflammation, Subacute | | 4 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 50 |
Infarct | | 1 3.0|
Inflammation, Multifocal, Subacute | | 2 3.0|
Inflammation, Necrotizing | | 1 3.0|
Renal Tubule, Bacterium | | 1 |
Renal Tubule, Cyst | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 49 |
Ectasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 4| 4| 0| 4| 5| 4| 5| 4| 4| 5| 3| 5| 5| 4| 4| 5| 5| 5| 4| 5|
DAY ON TEST | 1| 7| 1| 7| 7| 5| 8| 2| 6| 7| 9| 7| 1| 5| 0| 7| 2| 4| 2| 9| 5| 5| 1| 7| 3|
| 6| 9| 5| 9| 7| 0| 6| 9| 6| 2| 3| 7| 9| 1| 6| 6| 2| 4| 9| 8| 8| 0| 0| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
100 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + M + + + + + + + + +|
Inflammation, Necrotizing | 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + M + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Inflammation, Chronic Active, | |
Multifocal | 2 1 1 |
Inflammation, Diffuse, Subacute | |
Necrosis, Coagulative, Focal | |
Necrosis, Coagulative, Multifocal | 3 1 2 1 |
Thrombosis | |
Sinusoid, Centrilobular, Dilatation | 3 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Subacute | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + M + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Multifocal, Necrotizing| 2 |
Inflammation, Multifocal, Subacute | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Acute | 3 1 2 |
Inflammation, Necrotizing | 1 |
Ulcer | 3 |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Molar, | |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 4| 4| 0| 4| 5| 4| 5| 4| 4| 5| 3| 5| 5| 4| 4| 5| 5| 5| 4| 5|
DAY ON TEST | 1| 7| 1| 7| 7| 5| 8| 2| 6| 7| 9| 7| 1| 5| 0| 7| 2| 4| 2| 9| 5| 5| 1| 7| 3|
| 6| 9| 5| 9| 7| 0| 6| 9| 6| 2| 3| 7| 9| 1| 6| 6| 2| 4| 9| 8| 8| 0| 0| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
100 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Bacterium | X |
Aorta, Inflammation, Chronic Active | 2 |
Aorta, Thrombosis | X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 |
Dilatation | 3 |
Myocardium, Inflammation, Chronic, | |
Focal | |
Myocardium, Inflammation, Focal, | |
Subacute | |
Valve, Bacterium | X |
Valve, Inflammation, Subacute | 2 |
Valve, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 1 2 1 1 2 2 1 2 2 2 1 2 1 1 2 1 1 2 2 1 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + M + + + + + + + + I + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + M + + M + + + + M + + + M + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + M + M M M + M + + M|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 2 2 3 4 4 1 |
__________________________________________________________________________|
Preputial Gland | + |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + I|
Femoral, Necrosis, Caseous | |
Myeloid Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 4| 4| 0| 4| 5| 4| 5| 4| 4| 5| 3| 5| 5| 4| 4| 5| 5| 5| 4| 5|
DAY ON TEST | 1| 7| 1| 7| 7| 5| 8| 2| 6| 7| 9| 7| 1| 5| 0| 7| 2| 4| 2| 9| 5| 5| 1| 7| 3|
| 6| 9| 5| 9| 7| 0| 6| 9| 6| 2| 3| 7| 9| 1| 6| 6| 2| 4| 9| 8| 8| 0| 0| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
100 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + M + M|
Deep Cervical, Infiltration Cellular,| |
Polymorphonuclear | 2 |
Mediastinal, Infiltration Cellular, | |
Polymorphonuclear | 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + M + M|
Infiltration Cellular, | |
Polymorphonuclear | 2 1 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Hematopoietic Cell Proliferation | 2 |
Infiltration Cellular, | |
Polymorphonuclear | 3 1 3 |
Sinus, Ectasia | 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 4 2 4 3 2 4 2 3 4 4 4 4 4 4 4 4 4 3 3 4|
__________________________________________________________________________|
Thymus | + M M + M + + + + + M + M M + + + + + M M + M M +|
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + M M M M M M M M M M M + M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Cyst Epithelial Inclusion | X |
Inflammation, Acute | |
Inflammation, Chronic | |
Inflammation, Necrotizing | |
Back, Acanthosis | 3 |
Back, Hyperkeratosis | 1 1 |
Back, Inflammation, Necrotizing | 4 |
Lymphatic, Dilatation | |
Scapula, Acanthosis | 2 3 2 2 1 2 1 1 2 2 3 2 2 2|
Scapula, Hyperkeratosis | 2 2 1 1 2 1 2 2 1 2 |
Scapula, Inflammation, Necrotizing | 2 2 1 2 3 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Femur, Thrombosis | |
Tibia, Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 4| 4| 0| 4| 5| 4| 5| 4| 4| 5| 3| 5| 5| 4| 4| 5| 5| 5| 4| 5|
DAY ON TEST | 1| 7| 1| 7| 7| 5| 8| 2| 6| 7| 9| 7| 1| 5| 0| 7| 2| 4| 2| 9| 5| 5| 1| 7| 3|
| 6| 9| 5| 9| 7| 0| 6| 9| 6| 2| 3| 7| 9| 1| 6| 6| 2| 4| 9| 8| 8| 0| 0| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
100 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Autolysis | |
Hemorrhage, Multifocal | 1 |
Mineralization, Multifocal | 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 1 1 |
Hemorrhage, Multifocal | 2 |
Thrombosis | X |
Alveolar Epithelium, Hyperplasia | 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Interstitium, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + M + M M + + M + + + +|
Inflammation, Chronic, Focal | |
Inflammation, Subacute | 1 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Multifocal, Subacute | 2 |
Inflammation, Necrotizing | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 3| 5| 4| 5| 5| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 1| 1| 9| 6| 0| 1| 9| 8| 0| 7| 2| 2| 1| 3| 7| 7| 6| 0| 6| 5| 5| 5| 5| 5| 4|
| 5| 4| 9| 5| 5| 5| 3| 0| 8| 2| 0| 3| 6| 4| 9| 6| 5| 9| 5| 9| 9| 8| 8| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
100 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Inflammation, Chronic Active, | |
Multifocal | 2 2 3 4 |
Inflammation, Diffuse, Subacute | 3 |
Necrosis, Coagulative, Focal | |
Necrosis, Coagulative, Multifocal | 1 1 |
Thrombosis | X |
Sinusoid, Centrilobular, Dilatation | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Subacute | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Multifocal, Necrotizing| |
Inflammation, Multifocal, Subacute | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Acute | |
Inflammation, Necrotizing | |
Ulcer | 3 2 |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Molar, | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 3| 5| 4| 5| 5| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 1| 1| 9| 6| 0| 1| 9| 8| 0| 7| 2| 2| 1| 3| 7| 7| 6| 0| 6| 5| 5| 5| 5| 5| 4|
| 5| 4| 9| 5| 5| 5| 3| 0| 8| 2| 0| 3| 6| 4| 9| 6| 5| 9| 5| 9| 9| 8| 8| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
100 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Bacterium | |
Aorta, Inflammation, Chronic Active | |
Aorta, Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Dilatation | |
Myocardium, Inflammation, Chronic, | |
Focal | 1 1 1 |
Myocardium, Inflammation, Focal, | |
Subacute | 1 |
Valve, Bacterium | |
Valve, Inflammation, Subacute | |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 1 1 2 1 3 1 1 1 2 1 1 2 2 1 2 2 2 1 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Parathyroid Gland | M M + M + + + + + + + M + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | M I + M + + + + + + + + + + + M + + + M|
__________________________________________________________________________|
Thyroid Gland | M + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + M|
Inflammation, Subacute | 3 4 2 2 3 |
__________________________________________________________________________|
Preputial Gland | |
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 2 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Femoral, Necrosis, Caseous | 4 |
Myeloid Cell, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 3| 5| 4| 5| 5| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 1| 1| 9| 6| 0| 1| 9| 8| 0| 7| 2| 2| 1| 3| 7| 7| 6| 0| 6| 5| 5| 5| 5| 5| 4|
| 5| 4| 9| 5| 5| 5| 3| 0| 8| 2| 0| 3| 6| 4| 9| 6| 5| 9| 5| 9| 9| 8| 8| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
100 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + M|
Deep Cervical, Infiltration Cellular,| |
Polymorphonuclear | |
Mediastinal, Infiltration Cellular, | |
Polymorphonuclear | 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + M|
Infiltration Cellular, | |
Polymorphonuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
Hematopoietic Cell Proliferation | |
Infiltration Cellular, | |
Polymorphonuclear | 2 3 2 |
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 2 |
Hematopoietic Cell Proliferation | 3 3 3 4 4 4 4 4 3 4 4 4 3 4 4 4 |
__________________________________________________________________________|
Thymus | M + M M + M M + M M + + M M M + + M + M|
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M + M M M M M M M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Cyst Epithelial Inclusion | |
Inflammation, Acute | 2 |
Inflammation, Chronic | 1 |
Inflammation, Necrotizing | |
Back, Acanthosis | 1 |
Back, Hyperkeratosis | 1 1|
Back, Inflammation, Necrotizing | |
Lymphatic, Dilatation | 4 |
Scapula, Acanthosis | 1 1 2 2 2 2 2 1 2 2 1 3 3 3 3 3 2 2 |
Scapula, Hyperkeratosis | 1 1 2 1 2 2 1 1 1 |
Scapula, Inflammation, Necrotizing | 2 2 4 2 3 2 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Artery, Femur, Thrombosis | X |
Tibia, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
_____________________________________________________________________________________________________________________
| 3| 5| 4| 5| 5| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 1| 1| 9| 6| 0| 1| 9| 8| 0| 7| 2| 2| 1| 3| 7| 7| 6| 0| 6| 5| 5| 5| 5| 5| 4|
| 5| 4| 9| 5| 5| 5| 3| 0| 8| 2| 0| 3| 6| 4| 9| 6| 5| 9| 5| 9| 9| 8| 8| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
100 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Autolysis | 3 |
Hemorrhage, Multifocal | |
Mineralization, Multifocal | 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 1 |
Hemorrhage, Multifocal | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Interstitium, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + I + + + + + + + + M + + + M|
Inflammation, Chronic, Focal | 2 |
Inflammation, Subacute | 3 2 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Multifocal, Subacute | 2 3 |
Inflammation, Necrotizing | |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + + + + + + A + +|
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 2| 2| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 0| 0| 5| 5| 5| | |
| 9| 1| 8| 2| 8| 4| 4| 2| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
100 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 49 |
Inflammation, Necrotizing | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 48 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + | 50 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Inflammation, Chronic Active, | | |
Multifocal | | 7 2.1|
Inflammation, Diffuse, Subacute | | 1 3.0|
Necrosis, Coagulative, Focal | 1 | 1 1.0|
Necrosis, Coagulative, Multifocal | | 6 1.5|
Thrombosis | X | 2 |
Sinusoid, Centrilobular, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 49 |
Acinus, Atrophy | | 2 1.0|
Duct, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 50 |
Inflammation, Multifocal, Necrotizing| | 1 2.0|
Inflammation, Multifocal, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
Acanthosis | | 1 2.0|
Hyperkeratosis | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 50 |
Hyperplasia | | 2 1.5|
Inflammation, Acute | | 3 2.0|
Inflammation, Necrotizing | | 1 1.0|
Ulcer | 1 | 4 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 2| 2| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 0| 0| 5| 5| 5| | |
| 9| 1| 8| 2| 8| 4| 4| 2| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
100 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Molar, | | |
Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Bacterium | | 1 |
Aorta, Inflammation, Chronic Active | | 1 2.0|
Aorta, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + | 50 |
Cardiomyopathy | | 1 3.0|
Dilatation | | 1 3.0|
Myocardium, Inflammation, Chronic, | | |
Focal | | 3 1.0|
Myocardium, Inflammation, Focal, | | |
Subacute | | 1 1.0|
Valve, Bacterium | | 1 |
Valve, Inflammation, Subacute | | 1 2.0|
Valve, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 50 |
Capsule, Hyperplasia | 1 2 2 1 1 | 44 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 50 |
Hyperplasia, Nodular | | 5 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 47 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 48 |
Hyperplasia | | 4 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + | 38 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 38 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + | 49 |
Inflammation, Subacute | 2 | 13 2.6|
__________________________________________________________________________|____________|
Preputial Gland | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 2| 2| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 0| 0| 5| 5| 5| | |
| 9| 1| 8| 2| 8| 4| 4| 2| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
100 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Duct, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + | 50 |
Inflammation, Chronic Active | | 6 2.2|
__________________________________________________________________________|____________|
Testes | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 49 |
Femoral, Necrosis, Caseous | | 1 4.0|
Myeloid Cell, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + M + + + | 46 |
Deep Cervical, Infiltration Cellular,| | |
Polymorphonuclear | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Polymorphonuclear | | 2 2.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + | 44 |
Infiltration Cellular, | | |
Polymorphonuclear | 1 | 5 1.6|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 9 |
Hematopoietic Cell Proliferation | | 1 2.0|
Infiltration Cellular, | | |
Polymorphonuclear | | 6 2.3|
Sinus, Ectasia | | 3 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + | 50 |
Depletion Lymphoid | | 2 2.5|
Hematopoietic Cell Proliferation | 4 2 4 | 39 3.6|
__________________________________________________________________________|____________|
Thymus | + + + + M | 27 |
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M | 4 |
__________________________________________________________________________|____________|
Skin | + + + + + | 50 |
Acanthosis | 2 1 1 | 5 1.2|
Cyst Epithelial Inclusion | | 1 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Necrotizing | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 2| 2| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 0| 0| 5| 5| 5| | |
| 9| 1| 8| 2| 8| 4| 4| 2| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
100 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Back, Acanthosis | | 2 2.0|
Back, Hyperkeratosis | | 4 1.0|
Back, Inflammation, Necrotizing | | 1 4.0|
Lymphatic, Dilatation | | 1 4.0|
Scapula, Acanthosis | 2 2 2 | 35 2.0|
Scapula, Hyperkeratosis | 1 1 | 21 1.4|
Scapula, Inflammation, Necrotizing | 1 3 | 15 2.1|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 50 |
Artery, Femur, Thrombosis | | 1 |
Tibia, Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 50 |
Autolysis | | 1 3.0|
Hemorrhage, Multifocal | | 1 1.0|
Mineralization, Multifocal | 1 | 22 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 50 |
Hemorrhage, Focal | | 3 1.0|
Hemorrhage, Multifocal | | 1 2.0|
Thrombosis | | 1 |
Alveolar Epithelium, Hyperplasia | | 1 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Interstitium, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + | 42 |
Inflammation, Chronic, Focal | | 1 2.0|
Inflammation, Subacute | | 5 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 50 |
Inflammation, Multifocal, Subacute | | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 05044-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:51:59
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 2| 2| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 0| 0| 5| 5| 5| | |
| 9| 1| 8| 2| 8| 4| 4| 2| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
100 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Necrotizing | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
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