TDMS Study 05044-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/06/94
EXP: 05044 4-VINYL-1-CYCLOHEXENE DIEPOXIDE TIME: 19:52:34
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DERMAL,SOLUTION NTP C#: 60139A
CONT: N01-CP-95653 CAS: 106-87-6
PATHOLOGIST: M. RYAN
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/06/94
EXP: 05044 4-VINYL-1-CYCLOHEXENE DIEPOXIDE TIME: 19:52:34
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DERMAL,SOLUTION NTP C#: 60139A
CONT: N01-CP-95653 CAS: 106-87-6
PATHOLOGIST: M. RYAN
4-VINYL-1-CYCLOHEXENE DIEPOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/ML |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 9 CENSORED DEATHS 13 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 4 5 215 495 574 587 600 612 639 |
| CENSORED DEATHS |
| 438 458 458 458 458 458 458 459 459 459 |
| 459 624 624 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 25 MG/ML |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 15 CENSORED DEATHS 10 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 14 30 38 381 470 481 525 590 609 653 |
| 654 673 694 698 721 |
| CENSORED DEATHS |
| 458 458 458 458 459 459 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/ML |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 44 CENSORED DEATHS 12 TERMINAL 4 |
| |
| UNCENSORED DEATHS |
| 4 4 4 4 30 218 244 411 435 436 |
| 520 523 543 564 572 594 604 613 614 625 |
| 625 625 625 625 635 643 652 672 678 684 |
| 687 687 687 688 689 695 696 698 707 708 |
| 711 711 723 726 |
| CENSORED DEATHS |
| 42 458 458 458 458 458 459 459 459 459 |
| 459 527 |
| |
==================================================================================
4-VINYL-1-CYCLOHEXENE DIEPOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 100 MG/ ML |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 50 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 29 204 204 315 376 376 416 419 429 449 |
| 450 451 451 452 452 466 477 480 486 493 |
| 493 498 499 505 506 508 509 510 514 515 |
| 515 516 520 522 523 534 536 544 550 558 |
| 565 565 565 572 572 577 577 579 579 579 |
| CENSORED DEATHS |
| 458 458 458 458 458 459 459 459 459 459 |
| |
==================================================================================
4-VINYL-1-CYCLOHEXENE DIEPOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/ML | 96.7 96.7 95.0 95.0 95.0 95.0 92.9 86.7 82.5 82.5 |
| | |
| | |
|25 MG/ML | 95.0 95.0 95.0 95.0 93.3 89.3 87.2 85.2 79.1 71.0 |
| | |
| | |
|50 MG/ML | 91.7 91.7 88.3 88.3 86.6 83.2 76.7 68.0 46.0 8.8 |
| | |
| | |
|100 MG/ ML | 98.3 98.3 95.0 93.3 86.7 68.6 25.7 0.0 0.0 0.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/ML 25 MG/ML 50 MG/ML 100 MG/ M|
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 82.5% 71.0% 8.8% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.306 P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 414.6 482.1 541.8 479.6 |
|NATURAL DEATHS (C) | (88.3) (65.6) (33.7) (14.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 628.4 622.2 531.8 476.1 |
|(STANDARD ERROR) | (21.8) (23.0) (27.1) (12.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
4-VINYL-1-CYCLOHEXENE DIEPOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 593 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/ML |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 6 CENSORED DEATHS 12 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 392 451 451 500 534 569 |
| CENSORED DEATHS |
| 64 437 458 458 458 458 458 459 459 459 |
| 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 25 MG/ML |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 10 CENSORED DEATHS 11 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 31 196 217 415 428 457 515 553 556 576 |
| CENSORED DEATHS |
| 458 458 458 458 458 459 459 459 459 459 |
| 477 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/ML |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 15 CENSORED DEATHS 10 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 3 4 45 402 436 452 464 495 497 566 |
| 569 572 579 579 584 |
| CENSORED DEATHS |
| 458 458 458 458 458 459 459 459 459 459 |
| |
==================================================================================
4-VINYL-1-CYCLOHEXENE DIEPOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 593 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 100 MG/ ML |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 38 CENSORED DEATHS 10 TERMINAL 12 |
| |
| UNCENSORED DEATHS |
| 2 162 186 376 388 407 431 444 449 464 |
| 474 474 487 495 499 499 503 519 523 523 |
| 532 535 535 541 541 544 550 550 550 558 |
| 558 562 578 578 579 579 579 579 |
| CENSORED DEATHS |
| 458 458 458 458 458 459 459 459 459 459 |
| |
==================================================================================
4-VINYL-1-CYCLOHEXENE DIEPOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 593 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 593 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/ML | 100.0 100.0 100.0 100.0 98.3 94.9 90.6 88.5 88.5 88.5 |
| | |
| | |
|25 MG/ML | 98.3 98.3 95.0 95.0 93.3 90.0 87.9 81.6 81.6 81.6 |
| | |
| | |
|50 MG/ML | 95.0 95.0 95.0 95.0 93.3 88.0 83.9 71.6 71.6 71.6 |
| | |
| | |
|100 MG/ ML | 98.3 96.7 95.0 95.0 90.0 78.8 49.8 24.9 24.9 24.9 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/ML 25 MG/ML 50 MG/ML 100 MG/ M|
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 88.5% 81.6% 71.6% 24.9% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.417 P=0.061 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 482.8 394.4 416.5 482.4 |
|NATURAL DEATHS (C) | (26.2) (58.4) (55.5) (20.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 548.2 535.6 526.5 500.6 |
|(STANDARD ERROR) | (11.4) (14.0) (17.1) (14.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
4-VINYL-1-CYCLOHEXENE DIEPOXIDE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/ML = 1
25 MG/ML = 2
50 MG/ML = 3
100 MG/ ML = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 112 4
| 12 22 41
| 2 41 4 2 1
| 3 3 3 4 4 2 22 1 1
90 + 3 3 4 4 2 2 1 1 1
| 3 34 43 2 21 1
| 4 4 2 21 1
| 3 3 2 1 2 1
80 + 3 3 2 2
| 3 3 2 2
| 4 4 33
| 4 4 3 3 2 2
P 70 + 3 3 2 2
E | 444 33
R |
C | 44 3 3
E 60 +
N | 44
T |
| 33
S 50 + 33
U | 44 3 3
R | 3 33
V | 33
I 40 + 33
V | 4 4
A |
L | 4 4
30 +
| 44 33
| 44
| 444 33
20 + 33
|
| 44
| 3 3
10 + 44 3 3
|
|
|
0 + 4
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 13 obs hidden.
4-VINYL-1-CYCLOHEXENE DIEPOXIDE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/ML = 1
25 MG/ML = 2
50 MG/ML = 3
100 MG/ ML = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 13 2 1
| 3 2 3 4 42 2 1 1
| 3 4 2 4 3 2 1 1
| 4 4 3 42 23 32 1 1
90 + 4 4 323 2 1 1
| 4 4 4 3 3 2 2 1 1
| 4 4 3 223
| 44 23 32 2
P 80 + 4 4
E | 44 33
R | 4 4
C | 33 3
E 70 +
N | 4 4
T |
| 44
S 60 + 44
U |
R | 44
V |
I 50 + 4 4
V |
A |
L | 44
40 + 44
| 4 4
|
|
30 +
|
| 4 4
|
20 +
|
---+------------+------------+------------+------------+------------+------------+------------+------------+------------+--
0 10 20 30 40 50 60 70 80 90
WEEK
NOTE: 13 obs hidden.
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