TDMS Study 05044-01 Pathology Tables
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
Facility: Battelle Columbus Laboratory
Chemical CAS #: 106-87-6
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 4| 4| 6| 4| 7| 4| 4| 2| 4| 4| 4| 4| 4| 8| 2| 4| 4| 4| 0| 4| 4| 1| 4|
| 3| 6| 3| 3| 2| 3| 7| 3| 3| 9| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| 4| 4| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + A + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + A + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + M + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X |
Fatty Change | 1 1 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Acute, Necrotizing | |
Bile Duct, Hyperplasia | 1 |
Centrilobular, Necrosis | 2 |
Hepatocyte, Regeneration | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Acute, Necrotizing | 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + A + I + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Metaplasia | 1 |
Acinus, Atrophy | 1 1 1 1 2 2 1 3 2 4 2 |
Acinus, Hyperplasia | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Inflammation, Suppurative | |
Necrosis | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ulcer | 2 4 3 |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | 2 |
Inflammation, Chronic Active | |
Mineralization | |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 4| 4| 6| 4| 7| 4| 4| 2| 4| 4| 4| 4| 4| 8| 2| 4| 4| 4| 0| 4| 4| 1| 4|
| 3| 6| 3| 3| 2| 3| 7| 3| 3| 9| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| 4| 4| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Dysplasia | 2 |
Peridontal Tissue, Inflammation, | |
Suppurative | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 1 2 2 2 2 1 1 1 1 2 2 2 2 1 2 1 2 1 1 2 1 1 2 1|
Inflammation, Suppurative | |
Mineralization | |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 1 3 1 1 1 2 1 1 1 1 2 2 2 1|
Hypertrophy | 2 2 2 |
Necrosis | 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + I + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M M + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + M + +|
Cyst | |
Pars Distalis, Hyperplasia | 2 2 1 2 1 1 2 1 3 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + A + + + + + + + + + + + + + + + + + + A +|
Inflammation, Chronic Active | |
C-Cell, Hyperplasia | 2 2 2 2 2 1 1 1 2 1 1 1 1 2 1 3 2 1|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + + + + + + + + + + + + M + M + + + +|
Hyperplasia | 3 1 2 3 2 |
Inflammation, Chronic Active | 3 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Vagina | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 4| 4| 6| 4| 7| 4| 4| 2| 4| 4| 4| 4| 4| 8| 2| 4| 4| 4| 0| 4| 4| 1| 4|
| 3| 6| 3| 3| 2| 3| 7| 3| 3| 9| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| 4| 4| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | 1 2 3 4 |
Femoral, Myelofibrosis | |
Femoral, Necrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
Edema | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
__________________________________________________________________________|
Thymus | + M M + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 1 3 2 2 2 1 3 3 3 3 2 3 4 3 3 3 3 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | 3 |
Back, Acanthosis | |
Hair Follicle, Inflammation, Chronic | 2 |
Scapula, Acanthosis | 2 1 |
Scapula, Inflammation, Acute, | |
Necrotizing | 3 |
Sebaceous Gland, Scapula, Hypertrophy| 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | |
Femur, Fibrous Osteodystrophy | |
Mandible, Fibrous Osteodystrophy | |
Tarsal, Hyperostosis | |
Tarsal, Inflammation, Chronic Active | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X |
Infarct | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 4| 4| 6| 4| 7| 4| 4| 2| 4| 4| 4| 4| 4| 8| 2| 4| 4| 4| 0| 4| 4| 1| 4|
| 3| 6| 3| 3| 2| 3| 7| 3| 3| 9| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| 4| 4| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mineralization | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Thrombosis | X |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Degeneration | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Inflammation, Suppurative | |
Mineralization | |
Nephropathy, Chronic | 2 3 1 1 2 2 1 2 2 2 2 2 1 3 1 2 2 1 2 1 2 3 3 2|
Renal Tubule, Hyperplasia | 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 2| 6| 6| 7| 6| 7| 6| 6|
DAY ON TEST | 2| 4| 4| 2| 4| 1| 2| 4| 2| 4| 1| 4| 8| 9| 4| 4| 0| 2| 9| 3| 4| 0| 4| 0| 4|
| 5| 4| 4| 6| 4| 4| 5| 4| 5| 4| 9| 4| 6| 8| 4| 4| 9| 6| 8| 5| 4| 4| 4| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X|
Fatty Change | 3 2 4 2 2 1 3|
Hepatodiaphragmatic Nodule | X |
Inflammation, Acute, Necrotizing | 1 |
Bile Duct, Hyperplasia | 2 3 2 2 1 1|
Centrilobular, Necrosis | 4 3 2 2 |
Hepatocyte, Regeneration | 3 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Acute, Necrotizing | |
Inflammation, Chronic Active | 3 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Metaplasia | |
Acinus, Atrophy | 2 1 2 1 1 1 1 2|
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Suppurative | 1 |
Necrosis | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2|
Ulcer | 3 3 |
Epithelium, Hyperplasia | 1 2 2 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | 2 2 2 |
Inflammation, Chronic Active | 2 2 |
Mineralization | 3 |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 2| 6| 6| 7| 6| 7| 6| 6|
DAY ON TEST | 2| 4| 4| 2| 4| 1| 2| 4| 2| 4| 1| 4| 8| 9| 4| 4| 0| 2| 9| 3| 4| 0| 4| 0| 4|
| 5| 4| 4| 6| 4| 4| 5| 4| 5| 4| 9| 4| 6| 8| 4| 4| 9| 6| 8| 5| 4| 4| 4| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Dysplasia | |
Peridontal Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 1 2 1 1 2 1 1 2 2 2 1 2 2 1 2 2 2 1 2 1 2|
Inflammation, Suppurative | 2 |
Mineralization | 1 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 1 1 1 1 2 2 2 2 2 2 1 2 2 1 2 2 2 1|
Hypertrophy | 1 |
Necrosis | |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Cyst | X |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + A + + + + + + + + + + + + + + + A + + +|
Inflammation, Chronic Active | 1 |
C-Cell, Hyperplasia | 3 2 2 1 2 2 1 1 2 2 2 2 1 2 2 1 1 2 1|
Follicular Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + M + + + + + + + + + M +|
Hyperplasia | 1 |
Inflammation, Chronic Active | 2 4 2 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Vagina | + + +|
Inflammation, Suppurative | 2 3 3|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 2| 6| 6| 7| 6| 7| 6| 6|
DAY ON TEST | 2| 4| 4| 2| 4| 1| 2| 4| 2| 4| 1| 4| 8| 9| 4| 4| 0| 2| 9| 3| 4| 0| 4| 0| 4|
| 5| 4| 4| 6| 4| 4| 5| 4| 5| 4| 9| 4| 6| 8| 4| 4| 9| 6| 8| 5| 4| 4| 4| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | |
Femoral, Myelofibrosis | 2 2 2 |
Femoral, Necrosis | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + |
Edema | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 2 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + M + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 3 3 4 2 2 2 3 3 3 3 3 2 1 4 2 3 2 3 3 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | |
Back, Acanthosis | 1 |
Hair Follicle, Inflammation, Chronic | |
Scapula, Acanthosis | 1 1 |
Scapula, Inflammation, Acute, | |
Necrotizing | |
Sebaceous Gland, Scapula, Hypertrophy| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | X |
Femur, Fibrous Osteodystrophy | X |
Mandible, Fibrous Osteodystrophy | X |
Tarsal, Hyperostosis | X |
Tarsal, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X X X|
Infarct | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 2| 6| 6| 7| 6| 7| 6| 6|
DAY ON TEST | 2| 4| 4| 2| 4| 1| 2| 4| 2| 4| 1| 4| 8| 9| 4| 4| 0| 2| 9| 3| 4| 0| 4| 0| 4|
| 5| 4| 4| 6| 4| 4| 5| 4| 5| 4| 9| 4| 6| 8| 4| 4| 9| 6| 8| 5| 4| 4| 4| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mineralization | 2 |
__________________________________________________________________________|
Nose | + + + + + + M + + + + + + + + + + + + + + + + + +|
Mucosa, Thrombosis | X |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Degeneration | 2 3 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | X |
Inflammation, Suppurative | 2 |
Mineralization | 2 |
Nephropathy, Chronic | 3 2 3 2 1 1 2 2 4 2 2 1 2 2 2 1 2 2 2 1 2 1 2|
Renal Tubule, Hyperplasia | 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 9| 8| 9| 8| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 47 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 48 |
Inflammation, Suppurative | | 1 2.0|
Parasite Metazoan | | 5 |
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
Inflammation, Acute, Necrotizing | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 49 |
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus | | 38 |
Fatty Change | | 9 2.1|
Hepatodiaphragmatic Nodule | | 3 |
Inflammation, Acute, Necrotizing | | 1 1.0|
Bile Duct, Hyperplasia | | 7 1.7|
Centrilobular, Necrosis | | 5 2.6|
Hepatocyte, Regeneration | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Inflammation, Acute, Necrotizing | | 1 1.0|
Inflammation, Chronic Active | | 3 2.3|
__________________________________________________________________________|____________|
Pancreas | | 48 |
Inflammation, Chronic Active | | 2 2.0|
Metaplasia | | 1 1.0|
Acinus, Atrophy | | 19 1.6|
Acinus, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
Atrophy | | 1 3.0|
Inflammation, Suppurative | | 1 1.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Inflammation, Chronic Active | | 2 2.5|
Ulcer | | 5 3.0|
Epithelium, Hyperplasia | | 5 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 9| 8| 9| 8| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Acute, Necrotizing | | 4 2.0|
Inflammation, Chronic Active | | 2 2.0|
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | 2 |
Dysplasia | | 1 2.0|
Peridontal Tissue, Inflammation, | | |
Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Degeneration, Chronic | | 45 1.5|
Inflammation, Suppurative | | 1 2.0|
Mineralization | | 1 1.0|
Atrium, Thrombosis | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Hyperplasia | | 38 1.6|
Hypertrophy | | 4 1.8|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Hyperplasia | | 9 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 48 |
Hyperplasia | | 2 3.5|
__________________________________________________________________________|____________|
Parathyroid Gland | | 47 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | | 47 |
Cyst | | 1 |
Pars Distalis, Hyperplasia | | 19 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | | 46 |
Inflammation, Chronic Active | | 1 1.0|
C-Cell, Hyperplasia | | 37 1.6|
Follicular Cell, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 9| 8| 9| 8| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 45 |
Hyperplasia | | 6 2.0|
Inflammation, Chronic Active | | 8 2.4|
__________________________________________________________________________|____________|
Ovary | | 50 |
Cyst | | 4 |
__________________________________________________________________________|____________|
Uterus | | 50 |
__________________________________________________________________________|____________|
Vagina | | 3 |
Inflammation, Suppurative | | 3 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 3 |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Femoral, Hyperplasia, Reticulum Cell | | 4 2.5|
Femoral, Myelofibrosis | | 3 2.0|
Femoral, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 3 |
Edema | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Fibrosis | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | | 44 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 50 |
Hyperplasia, Cystic | | 41 2.7|
__________________________________________________________________________|____________|
Skin | | 50 |
Inflammation, Acute, Necrotizing | | 1 3.0|
Back, Acanthosis | | 1 1.0|
Hair Follicle, Inflammation, Chronic | | 1 2.0|
Scapula, Acanthosis | | 4 1.3|
Scapula, Inflammation, Acute, | | |
Necrotizing | | 1 3.0|
Sebaceous Gland, Scapula, Hypertrophy| | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Cranium, Fibrous Osteodystrophy | | 1 |
Femur, Fibrous Osteodystrophy | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 9| 8| 9| 8| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Mandible, Fibrous Osteodystrophy | | 1 |
Tarsal, Hyperostosis | | 1 |
Tarsal, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Compression | | 12 |
Infarct | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Inflammation, Chronic Active | | 4 1.3|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Nose | | 49 |
Mucosa, Thrombosis | | 2 |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 2.5|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 5 |
Degeneration | | 4 2.8|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Bacterium | | 1 |
Inflammation, Suppurative | | 1 2.0|
Mineralization | | 1 2.0|
Nephropathy, Chronic | | 47 1.9|
Renal Tubule, Hyperplasia | | 6 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 6| 6| 6| 5| 6| 7| 4| 7| 7| 6| 6| 5| 6| 7| 7| 6| 7| 6| 6|
DAY ON TEST | 7| 4| 0| 1| 4| 4| 7| 1| 2| 8| 0| 4| 1| 4| 3| 6| 3| 7| 7| 4| 4| 0| 4| 3| 1|
| 1| 3| 2| 8| 3| 3| 0| 3| 5| 4| 9| 3| 0| 3| 9| 1| 7| 2| 6| 3| 3| 8| 3| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Degeneration, Cystic | |
Eosinophilic Focus | |
Fatty Change | 2 2 2 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Focal | 3 |
Inflammation, Acute, Necrotizing | |
Inflammation, Chronic Active | 1 1 |
Bile Duct, Hyperplasia | 2 1 2 1 1 |
Centrilobular, Necrosis | 2 1 |
__________________________________________________________________________|
Mesentery | + + |
Artery, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + A + + + + + + +|
Focal Cellular Change | |
Inflammation, Chronic Active | |
Acinus, Atrophy | 1 2 2 1 2 2 1 1 1 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 2 |
Epithelium, Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Suppurative | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 6| 6| 6| 5| 6| 7| 4| 7| 7| 6| 6| 5| 6| 7| 7| 6| 7| 6| 6|
DAY ON TEST | 7| 4| 0| 1| 4| 4| 7| 1| 2| 8| 0| 4| 1| 4| 3| 6| 3| 7| 7| 4| 4| 0| 4| 3| 1|
| 1| 3| 2| 8| 3| 3| 0| 3| 5| 4| 9| 3| 0| 3| 9| 1| 7| 2| 6| 3| 3| 8| 3| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 1 1 2 2 1 2 1 1 1 2 1 1 2 2 1 1 1 1 2 2 1 1|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 1 1 1 1 2 2 2 1 1 1 2 1 |
Hypertrophy | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + A + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 1 2 2 2 2 2 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
C-Cell, Hyperplasia | 1 1 2 2 1 1 1 2 1 2 1 2 1 1 1 1 1|
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Acute, Necrotizing | 3 |
Inflammation, Chronic Active | |
Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + I + + + + + + + + + +|
Cyst | X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation, Chronic Active | |
Prolapse | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | |
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 6| 6| 6| 5| 6| 7| 4| 7| 7| 6| 6| 5| 6| 7| 7| 6| 7| 6| 6|
DAY ON TEST | 7| 4| 0| 1| 4| 4| 7| 1| 2| 8| 0| 4| 1| 4| 3| 6| 3| 7| 7| 4| 4| 0| 4| 3| 1|
| 1| 3| 2| 8| 3| 3| 0| 3| 5| 4| 9| 3| 0| 3| 9| 1| 7| 2| 6| 3| 3| 8| 3| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inflammation, Acute, Necrotizing | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
__________________________________________________________________________|
Thymus | M + M + + + M + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + I + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 2 2 1 2 1 3 2 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Back, Acanthosis | 1 |
Scapula, Acanthosis | 1 1 3 2 1 1 1 1 1 2 2 1 2 3 2 |
Scapula, Cyst Epithelial Inclusion | X |
Scapula, Inflammation, Acute, | |
Necrotizing | 1 |
Scapula, Inflammation, Chronic Active| |
Sebaceous Gland, Scapula, Hypertrophy| 1 2 1 1 1 1 2 2 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Degeneration | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Nephropathy, Chronic | 1 3 1 2 2 2 1 2 2 1 1 3 2 2 2 1 1 1 2 3 2 3 2 2|
Cortex, Atrophy, Focal | 3 |
Pelvis, Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 6| 6| 6| 5| 6| 7| 4| 7| 7| 6| 6| 5| 6| 7| 7| 6| 7| 6| 6|
DAY ON TEST | 7| 4| 0| 1| 4| 4| 7| 1| 2| 8| 0| 4| 1| 4| 3| 6| 3| 7| 7| 4| 4| 0| 4| 3| 1|
| 1| 3| 2| 8| 3| 3| 0| 3| 5| 4| 9| 3| 0| 3| 9| 1| 7| 2| 6| 3| 3| 8| 3| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 5| 7| 1| 6| 5| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 8| 4| 7| 4| 4| 0| 4| 4| 4| 4| 4| 1| 5| 3| 4| 6| 1| 9| 4|
| 3| 3| 3| 4| 4| 2| 7| 4| 1| 4| 4| 0| 4| 4| 4| 4| 4| 2| 6| 4| 4| 6| 9| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
50 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + M + + + + + + + + + + + + + + + + A +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + M + + + + +|
Parasite Metazoan | X X X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + M + + + + + + A + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X|
Clear Cell Focus | |
Degeneration, Cystic | 1 |
Eosinophilic Focus | X |
Fatty Change | 1 1 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Focal | |
Inflammation, Acute, Necrotizing | 2 |
Inflammation, Chronic Active | 1 2 |
Bile Duct, Hyperplasia | 1 2 1 1 1 |
Centrilobular, Necrosis | 3 1 1 |
__________________________________________________________________________|
Mesentery | |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + M A +|
Focal Cellular Change | X |
Inflammation, Chronic Active | 3 |
Acinus, Atrophy | 1 1 2 1 2 4 1 1|
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | 1 1 |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 5| 7| 1| 6| 5| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 8| 4| 7| 4| 4| 0| 4| 4| 4| 4| 4| 1| 5| 3| 4| 6| 1| 9| 4|
| 3| 3| 3| 4| 4| 2| 7| 4| 1| 4| 4| 0| 4| 4| 4| 4| 4| 2| 6| 4| 4| 6| 9| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
50 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 2 1 2 1 1 1 2 1 2 2 2 1 2 1 2 2 2 2|
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + A A +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + A A +|
Hyperplasia | 1 2 1 2 2 2 1 4 2 1 2 2 1 2 |
Hypertrophy | 3 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + A A +|
Hyperplasia | 1 2 2 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + M M + + M + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 3 2 3 2 3 2 3 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + A A +|
Inflammation, Chronic Active | |
C-Cell, Hyperplasia | 1 1 1 3 1 2 2 1 2 1 1 1 2 1 1 2 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2|
Inflammation, Acute, Necrotizing | |
Inflammation, Chronic Active | 3 3 |
Duct, Hyperplasia | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Inflammation, Chronic Active | 4 4 |
Prolapse | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + A +|
Femoral, Hyperplasia, Reticulum Cell | 3 2 2 1 3 |
Femoral, Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 5| 7| 1| 6| 5| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 8| 4| 7| 4| 4| 0| 4| 4| 4| 4| 4| 1| 5| 3| 4| 6| 1| 9| 4|
| 3| 3| 3| 4| 4| 2| 7| 4| 1| 4| 4| 0| 4| 4| 4| 4| 4| 2| 6| 4| 4| 6| 9| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
50 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inflammation, Acute, Necrotizing | 3|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + M + + M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 1 2 2 1 1 1 1 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Back, Acanthosis | 1 1 1 |
Scapula, Acanthosis | 2 2 1 2 1 1 2 2 1 2 2 1 2 1 1 1 1 2|
Scapula, Cyst Epithelial Inclusion | |
Scapula, Inflammation, Acute, | |
Necrotizing | |
Scapula, Inflammation, Chronic Active| 1 |
Sebaceous Gland, Scapula, Hypertrophy| 2 1 2 1 1 1 1 2 2 2 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 2 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Suppurative | 1 1|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Degeneration | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Nephropathy, Chronic | 2 2 2 2 2 1 1 2 2 1 1 3 2 3 2 3 2 2 2 3 3|
Cortex, Atrophy, Focal | |
Pelvis, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 5| 7| 1| 6| 5| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 8| 4| 7| 4| 4| 0| 4| 4| 4| 4| 4| 1| 5| 3| 4| 6| 1| 9| 4|
| 3| 3| 3| 4| 4| 2| 7| 4| 1| 4| 4| 0| 4| 4| 4| 4| 4| 2| 6| 4| 4| 6| 9| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
50 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 8| 9| 9| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 47 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 48 |
Parasite Metazoan | | 7 |
__________________________________________________________________________|____________|
Intestine Small | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 48 |
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus | | 32 |
Clear Cell Focus | | 2 |
Degeneration, Cystic | | 1 1.0|
Eosinophilic Focus | | 1 |
Fatty Change | | 5 1.6|
Hepatodiaphragmatic Nodule | | 2 |
Hyperplasia, Focal | | 1 3.0|
Inflammation, Acute, Necrotizing | | 1 2.0|
Inflammation, Chronic Active | | 4 1.3|
Bile Duct, Hyperplasia | | 10 1.3|
Centrilobular, Necrosis | | 5 1.6|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Artery, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | | 47 |
Focal Cellular Change | | 1 |
Inflammation, Chronic Active | | 1 3.0|
Acinus, Atrophy | | 17 1.5|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
Focal Cellular Change | | 1 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 48 |
Inflammation, Chronic Active | | 3 2.0|
Epithelium, Hyperplasia | | 4 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | | 48 |
Inflammation, Acute, Necrotizing | | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 8| 9| 9| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Inflammation, | | |
Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Degeneration, Chronic | | 40 1.5|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 48 |
Hyperplasia | | 29 1.6|
Hypertrophy | | 1 3.0|
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 48 |
Hyperplasia | | 10 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 43 |
__________________________________________________________________________|____________|
Pituitary Gland | | 49 |
Pars Distalis, Hyperplasia | | 20 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | | 48 |
Inflammation, Chronic Active | | 1 2.0|
C-Cell, Hyperplasia | | 33 1.4|
Follicular Cell, Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 50 |
Hyperplasia | | 3 2.0|
Inflammation, Acute, Necrotizing | | 1 3.0|
Inflammation, Chronic Active | | 2 3.0|
Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | | 49 |
Cyst | | 5 |
__________________________________________________________________________|____________|
Uterus | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 8| 9| 9| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Dilatation | | 1 3.0|
Inflammation, Chronic Active | | 2 4.0|
Prolapse | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 49 |
Femoral, Hyperplasia, Reticulum Cell | | 5 2.2|
Femoral, Myelofibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
Inflammation, Acute, Necrotizing | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Fibrosis | | 2 2.0|
__________________________________________________________________________|____________|
Thymus | | 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 49 |
Hyperplasia, Cystic | | 20 1.6|
__________________________________________________________________________|____________|
Skin | | 50 |
Back, Acanthosis | | 4 1.0|
Scapula, Acanthosis | | 33 1.5|
Scapula, Cyst Epithelial Inclusion | | 1 |
Scapula, Inflammation, Acute, | | |
Necrotizing | | 1 1.0|
Scapula, Inflammation, Chronic Active| | 1 1.0|
Sebaceous Gland, Scapula, Hypertrophy| | 20 1.4|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Compression | | 7 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Inflammation, Chronic Active | | 4 1.5|
Alveolar Epithelium, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Nose | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 8| 9| 9| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mucosa, Inflammation, Suppurative | | 2 1.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Degeneration | | 2 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Amyloid Deposition | | 1 2.0|
Nephropathy, Chronic | | 45 1.9|
Cortex, Atrophy, Focal | | 1 3.0|
Pelvis, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 7| 7| 5| 6| 5| 5| 6| 6| 4| 3| 6| 6| 6| 7| 6| 7| 5| 4| 6| 6| 6| 7| 6| 7| 5|
DAY ON TEST | 4| 4| 0| 8| 4| 2| 9| 5| 6| 9| 9| 2| 6| 4| 8| 4| 1| 0| 4| 0| 4| 4| 1| 4| 6|
| 3| 3| 8| 4| 2| 4| 4| 4| 0| 6| 0| 0| 1| 3| 1| 3| 9| 3| 0| 1| 8| 3| 9| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
100 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MG/ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A A + + + + + + + + A + A + + + + + + + A|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + A + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A A + A + + + + + + + + A + + + + + A + A|
Inflammation, Acute, Necrotizing | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + A + A + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X|
Fatty Change | |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Acute, Necrotizing | 2 |
Inflammation, Chronic Active | 3 |
Bile Duct, Hyperplasia | 2 1 1 1 1 1 1 |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + A + +|
Inflammation, Acute | 1 |
Acinus, Atrophy | 2 1 1 1 3 1 1 1 |
__________________________________________________________________________|
Pharynx | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Duct, Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | 4 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | |
Gingiva, Hyperplasia, Squamous | |
Peridontal Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 2 2 2 1 1 2 1 2 2 2 1 1 2 1 1 2 1|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 7| 7| 5| 6| 5| 5| 6| 6| 4| 3| 6| 6| 6| 7| 6| 7| 5| 4| 6| 6| 6| 7| 6| 7| 5|
DAY ON TEST | 4| 4| 0| 8| 4| 2| 9| 5| 6| 9| 9| 2| 6| 4| 8| 4| 1| 0| 4| 0| 4| 4| 1| 4| 6|
| 3| 3| 8| 4| 2| 4| 4| 4| 0| 6| 0| 0| 1| 3| 1| 3| 9| 3| 0| 1| 8| 3| 9| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
100 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MG/ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 1 1 1 1 2 2 2 2 2 1 2 1|
Hypertrophy | 2 1 |
Necrosis | 1 |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + I + + + + + + + + + + + + + A + +|
Pars Distalis, Degeneration, Focal | |
Pars Distalis, Hyperplasia | 3 2 1 3 3 3 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + A + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 1 2 1 1 2 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
Inflammation, Acute, Necrotizing | 4 3 |
Inflammation, Chronic Active | |
Duct, Hyperplasia | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Prolapse | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + A + +|
Femoral, Hyperplasia, Reticulum Cell | 1 1 1 |
Femoral, Necrosis | 2 |
Femoral, Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hematopoietic Cell | |
Proliferation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 7| 7| 5| 6| 5| 5| 6| 6| 4| 3| 6| 6| 6| 7| 6| 7| 5| 4| 6| 6| 6| 7| 6| 7| 5|
DAY ON TEST | 4| 4| 0| 8| 4| 2| 9| 5| 6| 9| 9| 2| 6| 4| 8| 4| 1| 0| 4| 0| 4| 4| 1| 4| 6|
| 3| 3| 8| 4| 2| 4| 4| 4| 0| 6| 0| 0| 1| 3| 1| 3| 9| 3| 0| 1| 8| 3| 9| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
100 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MG/ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | |
Edema | |
__________________________________________________________________________|
Spleen | + + + + A + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage, Chronic | |
__________________________________________________________________________|
Thymus | + + + + A + M + + + M + + + + + + + I M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 1 1 3 1 2 1 2 3 1 3 2 2 2 2 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Back, Acanthosis | 1 1 1 1 1 |
Back, Sebaceous Gland, Hypertrophy | 1 1 1 1 1 1 1 1 |
Scapula, Acanthosis | 2 2 2 2 1 3 2 2 1 2 3 2 3 2 2 2 3 2 2 2 2|
Scapula, Inflammation, Acute, | |
Necrotizing | 1 |
Sebaceous Gland, Scapula, Hypertrophy| 2 2 2 1 2 1 1 1 1 1 1 1 2 2 2 1 2 2 2 1 2 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Infarct | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 2 |
Mediastinum, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + A + +|
Hyperplasia, Squamous | |
Mucosa, Inflammation, Suppurative | 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + A + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Metaplasia, Squamous | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 7| 7| 5| 6| 5| 5| 6| 6| 4| 3| 6| 6| 6| 7| 6| 7| 5| 4| 6| 6| 6| 7| 6| 7| 5|
DAY ON TEST | 4| 4| 0| 8| 4| 2| 9| 5| 6| 9| 9| 2| 6| 4| 8| 4| 1| 0| 4| 0| 4| 4| 1| 4| 6|
| 3| 3| 8| 4| 2| 4| 4| 4| 0| 6| 0| 0| 1| 3| 1| 3| 9| 3| 0| 1| 8| 3| 9| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
100 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MG/ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Degeneration | 2 |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + A + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 2 2 2 1 1 1 1 2 2 1 1 1 1 2 1 1 1 1 1 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + + + + + +|
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 6| 5| 4| 6| 7| 7| 7| 6| 4| 6| 7| 7| 6| 6| 6| 7| 7| 6| 4|
DAY ON TEST | 9| 7| 9| 4| 4| 4| 1| 6| 1| 8| 4| 4| 4| 9| 0| 3| 4| 4| 7| 2| 8| 4| 4| 7| 9|
| 6| 6| 8| 8| 3| 4| 2| 4| 0| 9| 4| 4| 4| 5| 4| 5| 4| 4| 0| 0| 9| 4| 4| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
100 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MG/ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + M + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + A + + + + + +|
Inflammation, Acute, Necrotizing | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Fatty Change | 3 |
Hepatodiaphragmatic Nodule | |
Inflammation, Acute, Necrotizing | 1 |
Inflammation, Chronic Active | 1|
Bile Duct, Hyperplasia | 2 1 1 1 1 1 1 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Acinus, Atrophy | 1 1 2 2 1 2 1 1 1|
__________________________________________________________________________|
Pharynx | + |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Duct, Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + + |
Gingiva, Hyperplasia, Squamous | 2 |
Peridontal Tissue, Inflammation, | |
Suppurative | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 2 2 2 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1|
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 6| 5| 4| 6| 7| 7| 7| 6| 4| 6| 7| 7| 6| 6| 6| 7| 7| 6| 4|
DAY ON TEST | 9| 7| 9| 4| 4| 4| 1| 6| 1| 8| 4| 4| 4| 9| 0| 3| 4| 4| 7| 2| 8| 4| 4| 7| 9|
| 6| 6| 8| 8| 3| 4| 2| 4| 0| 9| 4| 4| 4| 5| 4| 5| 4| 4| 0| 0| 9| 4| 4| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
100 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MG/ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 2 2 1 2 2 2 1 2 1 2 2 1 1 1 3 1 1|
Hypertrophy | |
Necrosis | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Degeneration, Focal | 2 |
Pars Distalis, Hyperplasia | 2 2 3 2 2 1 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 1 1 1 1 2 1 1 1 2 2 1|
Follicular Cell, Hyperplasia | 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia | 1 3 |
Inflammation, Acute, Necrotizing | |
Inflammation, Chronic Active | 1 1 1 1 3 |
Duct, Hyperplasia | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Prolapse | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | 1 2 1|
Femoral, Necrosis | |
Femoral, Myeloid Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hematopoietic Cell | |
Proliferation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 6| 5| 4| 6| 7| 7| 7| 6| 4| 6| 7| 7| 6| 6| 6| 7| 7| 6| 4|
DAY ON TEST | 9| 7| 9| 4| 4| 4| 1| 6| 1| 8| 4| 4| 4| 9| 0| 3| 4| 4| 7| 2| 8| 4| 4| 7| 9|
| 6| 6| 8| 8| 3| 4| 2| 4| 0| 9| 4| 4| 4| 5| 4| 5| 4| 4| 0| 0| 9| 4| 4| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
100 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MG/ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + +|
Edema | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 3 |
Hemorrhage, Chronic | 4 |
__________________________________________________________________________|
Thymus | + + M + M + + + + + + + + + + + + + + M M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 2 2 2 3 1 1 1 2 1 1 1 2 2 1 1 2 1 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
Back, Acanthosis | 2 1 1 1 1 1 |
Back, Sebaceous Gland, Hypertrophy | 1 1 2 2 1 1 1 |
Scapula, Acanthosis | 1 3 3 2 2 1 1 1 2 1 1 3 2 3 3 3 2 2 2 3 2|
Scapula, Inflammation, Acute, | |
Necrotizing | |
Sebaceous Gland, Scapula, Hypertrophy| 1 2 2 1 1 2 1 1 1 1 2 2 2 2 2 2 2 1 1 2 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X|
Infarct | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 1 |
Mediastinum, Inflammation, Chronic | |
Active | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 1 |
Mucosa, Inflammation, Suppurative | 1 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 6| 5| 4| 6| 7| 7| 7| 6| 4| 6| 7| 7| 6| 6| 6| 7| 7| 6| 4|
DAY ON TEST | 9| 7| 9| 4| 4| 4| 1| 6| 1| 8| 4| 4| 4| 9| 0| 3| 4| 4| 7| 2| 8| 4| 4| 7| 9|
| 6| 6| 8| 8| 3| 4| 2| 4| 0| 9| 4| 4| 4| 5| 4| 5| 4| 4| 0| 0| 9| 4| 4| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
100 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MG/ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | + + |
Inflammation, Chronic | 2 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 1 1 2 1 1 1 1 1 2 2 1 2 1 1 2 2 1 3 1 1 1 2 3|
__________________________________________________________________________|
Urinary Bladder | + + + + M + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 8| 8| 9| 9| 8| 9| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
100 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MG/ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 45 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 48 |
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 48 |
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 42 |
Inflammation, Acute, Necrotizing | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 45 |
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis | | 1 2.0|
Basophilic Focus | | 35 |
Fatty Change | | 1 3.0|
Hepatodiaphragmatic Nodule | | 3 |
Inflammation, Acute, Necrotizing | | 2 1.5|
Inflammation, Chronic Active | | 2 2.0|
Bile Duct, Hyperplasia | | 14 1.1|
Centrilobular, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | | 48 |
Inflammation, Acute | | 1 1.0|
Acinus, Atrophy | | 17 1.4|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
Atrophy | | 1 2.0|
Duct, Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Inflammation, Acute, Necrotizing | | 1 4.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | 2 |
Gingiva, Hyperplasia, Squamous | | 1 2.0|
Peridontal Tissue, Inflammation, | | |
Suppurative | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 8| 8| 9| 9| 8| 9| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
100 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MG/ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Degeneration, Chronic | | 35 1.4|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Hyperplasia | | 34 1.6|
Hypertrophy | | 2 1.5|
Necrosis | | 1 1.0|
Vacuolization Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Hyperplasia | | 6 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | | 48 |
Pars Distalis, Degeneration, Focal | | 1 2.0|
Pars Distalis, Hyperplasia | | 15 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | | 49 |
C-Cell, Hyperplasia | | 23 1.3|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 49 |
Hyperplasia | | 4 1.5|
Inflammation, Acute, Necrotizing | | 2 3.5|
Inflammation, Chronic Active | | 5 1.4|
Duct, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Ovary | | 50 |
Cyst | | 9 |
__________________________________________________________________________|____________|
Uterus | | 50 |
Prolapse | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 8| 8| 9| 9| 8| 9| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
100 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MG/ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | | 49 |
Femoral, Hyperplasia, Reticulum Cell | | 6 1.2|
Femoral, Necrosis | | 1 2.0|
Femoral, Myeloid Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Mediastinal, Hematopoietic Cell | | |
Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
Hematopoietic Cell Proliferation | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 2 |
Edema | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | | 49 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | 3 2.3|
Hemorrhage, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | | 41 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 50 |
Hyperplasia, Cystic | | 37 1.7|
__________________________________________________________________________|____________|
Skin | | 50 |
Inflammation, Chronic Active | | 1 4.0|
Back, Acanthosis | | 11 1.1|
Back, Sebaceous Gland, Hypertrophy | | 15 1.1|
Scapula, Acanthosis | | 42 2.1|
Scapula, Inflammation, Acute, | | |
Necrotizing | | 1 1.0|
Sebaceous Gland, Scapula, Hypertrophy| | 43 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Compression | | 5 |
Infarct | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 8| 8| 9| 9| 8| 9| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
100 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MG/ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Inflammation, Chronic Active | | 6 1.5|
Mediastinum, Inflammation, Chronic | | |
Active | | 1 3.0|
__________________________________________________________________________|____________|
Nose | | 49 |
Hyperplasia, Squamous | | 1 1.0|
Mucosa, Inflammation, Suppurative | | 3 1.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 3 1.3|
__________________________________________________________________________|____________|
Trachea | | 49 |
Inflammation, Chronic Active | | 1 2.0|
Metaplasia, Squamous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Degeneration | | 2 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Inflammation, Chronic | | 2 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 49 |
Nephropathy, Chronic | | 46 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | | 48 |
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 6| 5| 6| 7| 6| 6| 6| 5| 5| 7| 4| 6| 6| 7| 5| 7| 7| 7| 6| 6| 6| 7| 5| 5| 6|
DAY ON TEST | 8| 7| 1| 4| 0| 7| 7| 0| 0| 4| 7| 2| 0| 3| 0| 4| 1| 4| 8| 0| 0| 4| 2| 5| 8|
| 2| 1| 9| 3| 2| 3| 3| 4| 9| 3| 0| 0| 8| 0| 9| 3| 2| 4| 2| 7| 2| 4| 5| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2|
Parasite Metazoan | X |
Thrombosis | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +|
Mineralization | 2 2 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2|
Mineralization | |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + M + + + + + +|
Inflammation, Acute, Necrotizing | 2 3 3 |
Thrombosis | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X |
Degeneration, Cystic | 2 2 2 |
Fatty Change | 1 2 2 |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic Active | 2 |
Bile Duct, Hyperplasia | 3 1 2 1 2 2 2 1 2|
Centrilobular, Necrosis | 2 3 1 1 3 1 |
__________________________________________________________________________|
Mesentery | + + + +|
Inflammation, Acute, Necrotizing | |
Inflammation, Chronic Active | 3 3|
Artery, Mineralization | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Acinus, Atrophy | 1 2 2 1 3 1 2 3 1 2 |
Acinus, Hyperplasia | 2 1 |
Artery, Mineralization | |
__________________________________________________________________________|
Pharynx | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Artery, Mineralization | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 6| 5| 6| 7| 6| 6| 6| 5| 5| 7| 4| 6| 6| 7| 5| 7| 7| 7| 6| 6| 6| 7| 5| 5| 6|
DAY ON TEST | 8| 7| 1| 4| 0| 7| 7| 0| 0| 4| 7| 2| 0| 3| 0| 4| 1| 4| 8| 0| 0| 4| 2| 5| 8|
| 2| 1| 9| 3| 2| 3| 3| 4| 9| 3| 0| 0| 8| 0| 9| 3| 2| 4| 2| 7| 2| 4| 5| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
Mineralization | 3 4 |
Ulcer | 2 4 2 1 4 |
Epithelium, Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | 2 2 1 3 1 1 2|
Mineralization | 4 3 1 4 |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Suppurative | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Aorta, Mineralization | 3 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 2 2 2 2 2 1 2 2 2 1 2 2 2 1 2 2 2 2 3 2 1 1 2 1|
Mineralization | 3 2 3 |
Atrium, Thrombosis | X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 1 1 2 1 3 2 1|
Hypertrophy | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 1 3 2 1 1 2 2 2 1 2 2 3 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 3 3 3 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 3 2 2 3 3 1 1 2 3 3 2 2 3|
Pars Distalis, Mineralization | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
C-Cell, Hyperplasia | 1 2 1 1 1 1 1 2 1 1 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ductus Deferens | + |
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 6| 5| 6| 7| 6| 6| 6| 5| 5| 7| 4| 6| 6| 7| 5| 7| 7| 7| 6| 6| 6| 7| 5| 5| 6|
DAY ON TEST | 8| 7| 1| 4| 0| 7| 7| 0| 0| 4| 7| 2| 0| 3| 0| 4| 1| 4| 8| 0| 0| 4| 2| 5| 8|
| 2| 1| 9| 3| 2| 3| 3| 4| 9| 3| 0| 0| 8| 0| 9| 3| 2| 4| 2| 7| 2| 4| 5| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 2 2 3 2 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + M + + +|
Inflammation, Chronic Active | 2 3 2 3 2 4 2 1 1 2 2 3 2 2 1 1 2|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | X |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 |
Seminiferous Tubule, Atrophy | 4 3 2 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 3 3|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Edema | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 3 |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + I + + + + + + + M + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 3 1 2 3 1 1 3 1 2 1 2 3 2 2 2 3 3 3 |
Mineralization | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Inflammation, Acute, Necrotizing | 3 2|
Mineralization | |
Scapula, Inflammation, Acute, | |
Necrotizing | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | 4 X X X X X |
Femur, Fibrous Osteodystrophy | 4 X X X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 6| 5| 6| 7| 6| 6| 6| 5| 5| 7| 4| 6| 6| 7| 5| 7| 7| 7| 6| 6| 6| 7| 5| 5| 6|
DAY ON TEST | 8| 7| 1| 4| 0| 7| 7| 0| 0| 4| 7| 2| 0| 3| 0| 4| 1| 4| 8| 0| 0| 4| 2| 5| 8|
| 2| 1| 9| 3| 2| 3| 3| 4| 9| 3| 0| 0| 8| 0| 9| 3| 2| 4| 2| 7| 2| 4| 5| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Infarct | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 1 2 3 |
Mineralization | 3 2 1 |
Thrombosis | X |
Artery, Mediastinum, Mineralization | 4 3 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Suppurative | 2 1 2 2 1 4 3 1 3 2 3 1 2 |
Mucosa, Thrombosis | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Septum, Necrosis | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Degeneration | 4 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 3 3 |
Nephropathy, Chronic | 4 2 2 2 2 3 4 1 1 3 1 3 2 3 2 2 4 3 2 4 3 4 1 2 4|
Pelvis, Inflammation, Suppurative | 3 |
Renal Tubule, Cytoplasmic Alteration | 2 |
Renal Tubule, Hyperplasia | 2 |
Renal Tubule, Necrosis | 3 |
__________________________________________________________________________|
Urethra | + |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hemorrhage | |
Inflammation, Suppurative | 1 |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 6| 6| 6| 4| 6| 7| 5| 7| 5| 6| 5| 4| 6| 6| 3| 5| 6| 5| 7| 5| 5| 5| 7| 6| 5|
DAY ON TEST | 8| 0| 4| 5| 6| 4| 3| 0| 8| 6| 4| 5| 9| 9| 7| 8| 1| 4| 3| 9| 8| 4| 4| 6| 9|
| 5| 7| 7| 8| 7| 4| 6| 7| 4| 9| 2| 8| 6| 0| 9| 2| 9| 8| 6| 6| 5| 8| 4| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A A + + A + + + + A + + + + + + + + +|
Inflammation, Suppurative | |
Parasite Metazoan | |
Thrombosis | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +|
Mineralization | 4 3 3 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + + + + + A + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Mineralization | 3 3 |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | 1 |
Thrombosis | |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + A + + + A + A + + A + + + + + + + + +|
Inflammation, Acute, Necrotizing | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + M + A + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X |
Degeneration, Cystic | 2 1 1 1 |
Fatty Change | 1 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic Active | |
Bile Duct, Hyperplasia | 2 1 2 2 2 3 1 1 2 1 4 |
Centrilobular, Necrosis | 4 2 2 2 1|
__________________________________________________________________________|
Mesentery | + + +|
Inflammation, Acute, Necrotizing | 3|
Inflammation, Chronic Active | |
Artery, Mineralization | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Acinus, Atrophy | 1 2 2 3 2 2 1 2 3 1 2 1 2 |
Acinus, Hyperplasia | |
Artery, Mineralization | 3 |
__________________________________________________________________________|
Pharynx | + + |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Artery, Mineralization | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 6| 6| 6| 4| 6| 7| 5| 7| 5| 6| 5| 4| 6| 6| 3| 5| 6| 5| 7| 5| 5| 5| 7| 6| 5|
DAY ON TEST | 8| 0| 4| 5| 6| 4| 3| 0| 8| 6| 4| 5| 9| 9| 7| 8| 1| 4| 3| 9| 8| 4| 4| 6| 9|
| 5| 7| 7| 8| 7| 4| 6| 7| 4| 9| 2| 8| 6| 0| 9| 2| 9| 8| 6| 6| 5| 8| 4| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2 |
Mineralization | 3 3 4 3 |
Ulcer | 2 1 4|
Epithelium, Hyperplasia | 1 3 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | 3 2 2 2|
Mineralization | 3 4 4 4 3 3 |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Suppurative | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + |
Aorta, Mineralization | 4 3 4 3 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 2 3 2 3 3 2 3 2 1 2 3 3 2 2 2 1 1 1 1 1 2|
Mineralization | 2 3 3 4 3 2 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 2 2 2 1 2 1 2 2 1 |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 2 2 1 1 2 2 1 2 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 2 3 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 3 4 3 3 2 1 2 3 1 |
Pars Distalis, Mineralization | 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + A + + + A + + + + + + + + + + + + + +|
Mineralization | |
C-Cell, Hyperplasia | 1 1 1 2 1 1 1 1 2 2 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ductus Deferens | + |
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 6| 6| 6| 4| 6| 7| 5| 7| 5| 6| 5| 4| 6| 6| 3| 5| 6| 5| 7| 5| 5| 5| 7| 6| 5|
DAY ON TEST | 8| 0| 4| 5| 6| 4| 3| 0| 8| 6| 4| 5| 9| 9| 7| 8| 1| 4| 3| 9| 8| 4| 4| 6| 9|
| 5| 7| 7| 8| 7| 4| 6| 7| 4| 9| 2| 8| 6| 0| 9| 2| 9| 8| 6| 6| 5| 8| 4| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic Active | 1 2 1 4 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 4 2 4 1 2 3 3 2 2 1 2 2 3 1 3|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
Interstitial Cell, Hyperplasia | 1 1 1 1|
Seminiferous Tubule, Atrophy | 3 3 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Edema | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 3 1 3 1 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + M + M + A M I + + + + M + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + M M + + M + + M + + + + + +|
Hyperplasia, Cystic | 2 2 2 2 2 2 1 2 2 1 3 2 3 3 3|
Mineralization | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Inflammation, Acute, Necrotizing | 1 |
Mineralization | 3 |
Scapula, Inflammation, Acute, | |
Necrotizing | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | X X X X X X X |
Femur, Fibrous Osteodystrophy | X X X X X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 6| 6| 6| 4| 6| 7| 5| 7| 5| 6| 5| 4| 6| 6| 3| 5| 6| 5| 7| 5| 5| 5| 7| 6| 5|
DAY ON TEST | 8| 0| 4| 5| 6| 4| 3| 0| 8| 6| 4| 5| 9| 9| 7| 8| 1| 4| 3| 9| 8| 4| 4| 6| 9|
| 5| 7| 7| 8| 7| 4| 6| 7| 4| 9| 2| 8| 6| 0| 9| 2| 9| 8| 6| 6| 5| 8| 4| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Infarct | 3 3 2 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 3 3 2 1 4 |
Mineralization | 3 3 3 3 2 2 |
Thrombosis | |
Artery, Mediastinum, Mineralization | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Suppurative | 3 2 2 3 2 2 1 1 |
Mucosa, Thrombosis | X |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 3 2 |
Septum, Necrosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Degeneration | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 4 4 4 3 3 |
Nephropathy, Chronic | 4 4 4 1 4 3 2 4 2 3 2 1 4 4 1 2 2 1 3 2 2 2 3 2 3|
Pelvis, Inflammation, Suppurative | 1 |
Renal Tubule, Cytoplasmic Alteration | 2 |
Renal Tubule, Hyperplasia | 2 |
Renal Tubule, Necrosis | |
__________________________________________________________________________|
Urethra | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Inflammation, Suppurative | 1 |
Mineralization | 2 2 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 8| 8| 9| 8| 9| 9| 9| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 45 |
Inflammation, Suppurative | | 1 2.0|
Parasite Metazoan | | 1 |
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 48 |
Mineralization | | 5 2.8|
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 48 |
Inflammation, Suppurative | | 1 2.0|
Mineralization | | 2 3.0|
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Small | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 48 |
Inflammation, Acute, Necrotizing | | 4 2.3|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 44 |
Inflammation, Acute, Necrotizing | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 46 |
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus | | 15 |
Degeneration, Cystic | | 7 1.6|
Fatty Change | | 5 1.4|
Hepatodiaphragmatic Nodule | | 1 |
Inflammation, Chronic Active | | 1 2.0|
Bile Duct, Hyperplasia | | 20 1.9|
Centrilobular, Necrosis | | 11 2.0|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Inflammation, Acute, Necrotizing | | 1 3.0|
Inflammation, Chronic Active | | 2 3.0|
Artery, Mineralization | | 4 2.8|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Inflammation, Chronic Active | | 1 3.0|
Acinus, Atrophy | | 23 1.8|
Acinus, Hyperplasia | | 2 1.5|
Artery, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Pharynx | | 2 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 8| 8| 9| 8| 9| 9| 9| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
Inflammation, Suppurative | | 1 2.0|
Artery, Mineralization | | 2 2.5|
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Inflammation, Chronic Active | | 1 2.0|
Mineralization | | 6 3.3|
Ulcer | | 8 2.5|
Epithelium, Hyperplasia | | 6 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Inflammation, Acute, Necrotizing | | 11 1.9|
Mineralization | | 10 3.3|
__________________________________________________________________________|____________|
Tooth | | 2 |
Peridontal Tissue, Inflammation, | | |
Suppurative | | 2 3.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 7 |
Aorta, Mineralization | | 7 3.4|
__________________________________________________________________________|____________|
Heart | | 50 |
Degeneration, Chronic | | 45 1.9|
Mineralization | | 9 2.8|
Atrium, Thrombosis | | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Hyperplasia | | 23 1.7|
Hypertrophy | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Hyperplasia | | 28 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 49 |
Hyperplasia | | 14 2.6|
__________________________________________________________________________|____________|
Pituitary Gland | | 50 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | | 23 2.3|
Pars Distalis, Mineralization | | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 8| 8| 9| 8| 9| 9| 9| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | | 48 |
Mineralization | | 1 3.0|
C-Cell, Hyperplasia | | 28 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ductus Deferens | | 2 |
Mineralization | | 2 3.0|
__________________________________________________________________________|____________|
Epididymis | | 50 |
__________________________________________________________________________|____________|
Preputial Gland | | 49 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic Active | | 11 2.2|
__________________________________________________________________________|____________|
Prostate | | 49 |
Inflammation, Chronic Active | | 34 2.1|
__________________________________________________________________________|____________|
Testes | | 50 |
Thrombosis | | 1 |
Interstitial Cell, Hyperplasia | | 9 1.0|
Seminiferous Tubule, Atrophy | | 9 3.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 7 |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Femoral, Myelofibrosis | | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 7 |
Edema | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Fibrosis | | 8 2.1|
Hematopoietic Cell Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | | 41 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 45 |
Hyperplasia, Cystic | | 34 2.1|
Mineralization | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 8| 8| 9| 8| 9| 9| 9| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | | 50 |
Abscess | | 2 3.5|
Inflammation, Acute, Necrotizing | | 3 2.0|
Mineralization | | 1 3.0|
Scapula, Inflammation, Acute, | | |
Necrotizing | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Cranium, Fibrous Osteodystrophy | | 13 4.0|
Femur, Fibrous Osteodystrophy | | 13 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Compression | | 7 |
Infarct | | 4 2.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Inflammation, Chronic Active | | 11 2.4|
Mineralization | | 9 2.4|
Thrombosis | | 1 |
Artery, Mediastinum, Mineralization | | 3 3.3|
__________________________________________________________________________|____________|
Nose | | 50 |
Mucosa, Inflammation, Suppurative | | 21 2.0|
Mucosa, Thrombosis | | 1 |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 3 2.3|
Septum, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 7 |
Degeneration | | 3 3.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Mineralization | | 9 3.3|
Nephropathy, Chronic | | 50 2.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 8| 8| 9| 8| 9| 9| 9| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Pelvis, Inflammation, Suppurative | | 2 2.0|
Renal Tubule, Cytoplasmic Alteration | | 2 2.0|
Renal Tubule, Hyperplasia | | 2 2.0|
Renal Tubule, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 49 |
Hemorrhage | | 1 4.0|
Inflammation, Suppurative | | 2 1.0|
Mineralization | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 6| 0| 6| 5| 5| 6| 6| 6| 5| 4| 7| 6| 7| 6| 7| 6| 6| 3| 6| 7| 7| 6| 7| 6| 6|
DAY ON TEST | 7| 7| 6| 9| 3| 6| 4| 8| 7| 8| 4| 7| 0| 0| 1| 1| 4| 8| 9| 3| 2| 8| 4| 7| 4|
| 5| 9| 8| 6| 8| 2| 2| 8| 1| 9| 3| 6| 4| 9| 2| 1| 7| 7| 5| 6| 2| 9| 3| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 2 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | 3 2 |
Mineralization | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + M + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X |
Degeneration, Cystic | 2 4 2 2 |
Eosinophilic Focus | X |
Fatty Change | 1 2 2 2 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Acute, Necrotizing | 2 3 |
Thrombosis | X |
Bile Duct, Hyperplasia | 2 3 1 3 2 3 1 2 1 2 1 1 1 3 2 2 1 1 3 |
Centrilobular, Necrosis | 3 1 |
Hepatocyte, Regeneration | |
__________________________________________________________________________|
Mesentery | + + + |
Artery, Mineralization | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 3 1 2 2 1 2 1 2 2 1|
__________________________________________________________________________|
Pharynx | + + |
Inflammation, Suppurative | 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 2 2 1 1 |
Mineralization | 2 |
Ulcer | 4 3 |
Epithelium, Hyperplasia | 3 2 2 3 2 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | |
Mineralization | 3 3 3 2 3 2 4 2|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 6| 0| 6| 5| 5| 6| 6| 6| 5| 4| 7| 6| 7| 6| 7| 6| 6| 3| 6| 7| 7| 6| 7| 6| 6|
DAY ON TEST | 7| 7| 6| 9| 3| 6| 4| 8| 7| 8| 4| 7| 0| 0| 1| 1| 4| 8| 9| 3| 2| 8| 4| 7| 4|
| 5| 9| 8| 6| 8| 2| 2| 8| 1| 9| 3| 6| 4| 9| 2| 1| 7| 7| 5| 6| 2| 9| 3| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + + |
Dysplasia | 1 |
Peridontal Tissue, Inflammation, | |
Suppurative | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + +|
Aneurysm | X |
Aorta, Mineralization | 3 4 2|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 3 2 2 1 1 2 1 1 1 1 1 1 2 3 2 2 1 2 3 3 1 3|
Inflammation, Suppurative | 2 1|
Mineralization | 2 2 2 3 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 2 2 3 2 1 1 1 1 2 2 1|
Necrosis | 3 1 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 2 2 2 2 3 4|
Hypertrophy | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 3 3 3 |
Pars Distalis, Mineralization | 2 |
Pars Distalis, Necrosis | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Pigmentation, Lipofuscin | |
C-Cell, Hyperplasia | 1 2 1 1 1 1 1 1 1 2 2 1 1|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 6| 0| 6| 5| 5| 6| 6| 6| 5| 4| 7| 6| 7| 6| 7| 6| 6| 3| 6| 7| 7| 6| 7| 6| 6|
DAY ON TEST | 7| 7| 6| 9| 3| 6| 4| 8| 7| 8| 4| 7| 0| 0| 1| 1| 4| 8| 9| 3| 2| 8| 4| 7| 4|
| 5| 9| 8| 6| 8| 2| 2| 8| 1| 9| 3| 6| 4| 9| 2| 1| 7| 7| 5| 6| 2| 9| 3| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 2 2 1 2 1 2 |
Duct, Hyperplasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 1 1 1 1 1 4 1 4 2 3 4 1 |
__________________________________________________________________________|
Seminal Vesicle | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Interstitial Cell, Hyperplasia | 1 2 |
Seminiferous Tubule, Atrophy | 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + |
Edema | 3 2 |
Hemorrhage | 3 |
Inflammation, Acute, Necrotizing | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 3 1 |
Hematopoietic Cell Proliferation | 3 |
Hemorrhage, Chronic | |
Necrosis | 3 |
__________________________________________________________________________|
Thymus | + + + M + + + + M + + M + I + + + + + + + + + M +|
Inflammation, Acute, Necrotizing | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia, Cystic | 2 2 1 2 3 2 2 1 2 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Acute, Necrotizing | 1 |
Back, Acanthosis | 1 1 |
Back, Inflammation, Acute, | |
Necrotizing | 1 |
Back, Sebaceous Gland, Hypertrophy | 1 |
Scapula, Acanthosis | 1 1 1 2 1 1 1 2 1 1 2 1 1 1 1 1 1 1|
Scapula, Cyst Epithelial Inclusion | X |
Scapula, Hypertrophy | 1 1 |
Sebaceous Gland, Hypertrophy | 1 |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 6| 0| 6| 5| 5| 6| 6| 6| 5| 4| 7| 6| 7| 6| 7| 6| 6| 3| 6| 7| 7| 6| 7| 6| 6|
DAY ON TEST | 7| 7| 6| 9| 3| 6| 4| 8| 7| 8| 4| 7| 0| 0| 1| 1| 4| 8| 9| 3| 2| 8| 4| 7| 4|
| 5| 9| 8| 6| 8| 2| 2| 8| 1| 9| 3| 6| 4| 9| 2| 1| 7| 7| 5| 6| 2| 9| 3| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Sebaceous Gland, Scapula, Hypertrophy| 1 2 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | X X X X X X X X|
Femur, Fibrous Osteodystrophy | X X X X X X X X|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X |
Infarct | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Inflammation, Chronic Active | 2 2 1 1 2 2 4 2 2|
Mineralization | 2 2 2 2 2|
Alveolar Epithelium, Hyperplasia | 1 2 |
Artery, Mediastinum, Mineralization | 2 3 3 3 2|
Mediastinum, Inflammation, Chronic | |
Active | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Suppurative | 2 1 3 2 4 4 1 1 1|
Mucosa, Thrombosis | X |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + M + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Degeneration | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Mineralization | 3 3 2 3 2|
Nephropathy, Chronic | 4 4 3 2 2 4 4 2 2 3 3 3 4 4 2 3 2 1 3 4 4 3 3 4|
Pelvis, Inflammation, Suppurative | 1 2 2 1 |
Renal Tubule, Hyperplasia | 2 2 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 7| 3| 5| 7| 5| 4| 6| 7| 6| 7| 6| 3| 7| 4| 6| 7| 6| 5| 5| 7| 7| 7| 6| 6| 4|
DAY ON TEST | 3| 7| 6| 4| 4| 0| 7| 3| 7| 4| 8| 8| 4| 6| 2| 4| 8| 3| 7| 4| 4| 1| 1| 3| 5|
| 0| 3| 9| 3| 2| 4| 6| 6| 4| 3| 9| 9| 4| 7| 6| 4| 9| 8| 6| 4| 4| 8| 3| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
50 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + |
Mineralization | 3 |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + |
Mineralization | 3 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute, Necrotizing | 2 1 3 |
Mineralization | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute, Necrotizing | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | X X X X X X X |
Degeneration, Cystic | 1 2 1 |
Eosinophilic Focus | |
Fatty Change | 2 1 |
Hepatodiaphragmatic Nodule | |
Inflammation, Acute, Necrotizing | 2 |
Thrombosis | |
Bile Duct, Hyperplasia | 1 1 1 2 1 2 2 1 1 1 1 1 2 2 3 2 2 2 1 3 |
Centrilobular, Necrosis | 1 2 3 3 3 2 4 |
Hepatocyte, Regeneration | 4 |
__________________________________________________________________________|
Mesentery | + + + |
Artery, Mineralization | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + |
Acinus, Atrophy | 2 2 2 1 2 1 1 1 1 1 2 |
__________________________________________________________________________|
Pharynx | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + |
Necrosis | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 2 1 |
Mineralization | 4 3 |
Ulcer | 1 4 3 4 |
Epithelium, Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute, Necrotizing | 1 1 2 |
Mineralization | 2 4 3 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 7| 3| 5| 7| 5| 4| 6| 7| 6| 7| 6| 3| 7| 4| 6| 7| 6| 5| 5| 7| 7| 7| 6| 6| 4|
DAY ON TEST | 3| 7| 6| 4| 4| 0| 7| 3| 7| 4| 8| 8| 4| 6| 2| 4| 8| 3| 7| 4| 4| 1| 1| 3| 5|
| 0| 3| 9| 3| 2| 4| 6| 6| 4| 3| 9| 9| 4| 7| 6| 4| 9| 8| 6| 4| 4| 8| 3| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
50 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + + + |
Dysplasia | |
Peridontal Tissue, Inflammation, | |
Suppurative | 2 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aneurysm | |
Aorta, Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + |
Degeneration, Chronic | 2 2 2 2 3 2 2 2 4 2 1 2 2 2 1 2 2 2 1 3 |
Inflammation, Suppurative | |
Mineralization | 2 2 3 |
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 2 2 1 2 2 2 1 1 |
Necrosis | 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 3 3 1 2 1 1 1 1 2 2 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + M + + + + + + + + + M + |
Hyperplasia | 2 1 3 3 2 |
Hypertrophy | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Hyperplasia | 1 1 3 3 3 2 |
Pars Distalis, Mineralization | |
Pars Distalis, Necrosis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + |
Mineralization | |
Pigmentation, Lipofuscin | 3 |
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 7| 3| 5| 7| 5| 4| 6| 7| 6| 7| 6| 3| 7| 4| 6| 7| 6| 5| 5| 7| 7| 7| 6| 6| 4|
DAY ON TEST | 3| 7| 6| 4| 4| 0| 7| 3| 7| 4| 8| 8| 4| 6| 2| 4| 8| 3| 7| 4| 4| 1| 1| 3| 5|
| 0| 3| 9| 3| 2| 4| 6| 6| 4| 3| 9| 9| 4| 7| 6| 4| 9| 8| 6| 4| 4| 8| 3| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
50 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + M + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 2 3 3 3 2 1 |
Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 3 2 2 2 3 3 2 4 3 3 2 1 2 2 1 2 |
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + |
Cyst | |
Interstitial Cell, Hyperplasia | 1 2 1 1 |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + |
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute, Necrotizing | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Edema | 3 2 |
Hemorrhage | |
Inflammation, Acute, Necrotizing | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + |
Fibrosis | 2 1 2 4 2 |
Hematopoietic Cell Proliferation | |
Hemorrhage, Chronic | 4 |
Necrosis | 2 4 |
__________________________________________________________________________|
Thymus | M M + + + M + + + + + + + + + + + + M + + + + + |
Inflammation, Acute, Necrotizing | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Cystic | 2 3 2 1 2 2 2 2 1 1 2 2 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + |
Acanthosis | 1 1 |
Inflammation, Acute, Necrotizing | |
Back, Acanthosis | 2 2 1 2 |
Back, Inflammation, Acute, | |
Necrotizing | |
Back, Sebaceous Gland, Hypertrophy | 2 1 1 |
Scapula, Acanthosis | 1 1 1 1 1 1 2 1 1 1 1 2 2 2 2 1 2 1 2 2 |
Scapula, Cyst Epithelial Inclusion | |
Scapula, Hypertrophy | |
Sebaceous Gland, Hypertrophy | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 7| 3| 5| 7| 5| 4| 6| 7| 6| 7| 6| 3| 7| 4| 6| 7| 6| 5| 5| 7| 7| 7| 6| 6| 4|
DAY ON TEST | 3| 7| 6| 4| 4| 0| 7| 3| 7| 4| 8| 8| 4| 6| 2| 4| 8| 3| 7| 4| 4| 1| 1| 3| 5|
| 0| 3| 9| 3| 2| 4| 6| 6| 4| 3| 9| 9| 4| 7| 6| 4| 9| 8| 6| 4| 4| 8| 3| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
50 MG/ML | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Sebaceous Gland, Scapula, Hypertrophy| 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + |
Cranium, Fibrous Osteodystrophy | X X X X |
Femur, Fibrous Osteodystrophy | X X X X |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + |
Compression | X X X X |
Infarct | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + |
Infarct | 3 |
Inflammation, Chronic Active | 3 2 2 2 1 2 |
Mineralization | 2 3 |
Alveolar Epithelium, Hyperplasia | 2 |
Artery, Mediastinum, Mineralization | 3 |
Mediastinum, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + |
Mucosa, Inflammation, Suppurative | 2 2 1 |
Mucosa, Thrombosis | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Degeneration | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + |
Hydronephrosis | 4 |
Mineralization | 3 4 |
Nephropathy, Chronic | 3 2 4 3 2 2 4 4 3 2 4 2 3 2 2 4 2 2 2 2 3 3 3 2 |
Pelvis, Inflammation, Suppurative | 2 |
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| | |
| 9| 8| 8| 9| 7| 8| 9| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 48 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 49 |
Mineralization | | 3 2.7|
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 48 |
Mineralization | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small | + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 50 |
Inflammation, Acute, Necrotizing | | 5 2.2|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 49 |
Inflammation, Acute, Necrotizing | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 49 |
__________________________________________________________________________|____________|
Liver | + | 50 |
Basophilic Focus | | 15 |
Degeneration, Cystic | | 7 2.0|
Eosinophilic Focus | | 1 |
Fatty Change | | 6 1.7|
Hepatodiaphragmatic Nodule | | 1 |
Inflammation, Acute, Necrotizing | | 3 2.3|
Thrombosis | | 1 |
Bile Duct, Hyperplasia | | 39 1.7|
Centrilobular, Necrosis | | 9 2.4|
Hepatocyte, Regeneration | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | | 6 |
Artery, Mineralization | | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | + | 50 |
Acinus, Atrophy | | 24 1.5|
__________________________________________________________________________|____________|
Pharynx | | 2 |
Inflammation, Suppurative | | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + | 50 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 50 |
Inflammation, Chronic Active | 2 | 10 1.6|
Mineralization | | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| | |
| 9| 8| 8| 9| 7| 8| 9| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | | 6 3.2|
Epithelium, Hyperplasia | | 10 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 50 |
Inflammation, Acute, Necrotizing | | 3 1.3|
Mineralization | | 11 2.8|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | 5 |
Dysplasia | | 1 1.0|
Peridontal Tissue, Inflammation, | | |
Suppurative | | 4 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 5 |
Aneurysm | | 1 |
Aorta, Mineralization | | 4 3.0|
__________________________________________________________________________|____________|
Heart | + | 50 |
Degeneration, Chronic | | 42 1.9|
Inflammation, Suppurative | | 2 1.5|
Mineralization | | 7 2.3|
Atrium, Thrombosis | | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + | 50 |
Hyperplasia | | 24 1.6|
Necrosis | | 3 2.0|
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + | 50 |
Hyperplasia | | 28 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + | 45 |
Hyperplasia | | 14 2.4|
Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + | 50 |
Pars Distalis, Hyperplasia | | 10 2.4|
Pars Distalis, Mineralization | | 1 2.0|
Pars Distalis, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| | |
| 9| 8| 8| 9| 7| 8| 9| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Mineralization | | 1 1.0|
Pigmentation, Lipofuscin | | 1 3.0|
C-Cell, Hyperplasia | 1 | 30 1.1|
Follicular Cell, Hyperplasia | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + | 50 |
__________________________________________________________________________|____________|
Preputial Gland | + | 49 |
Inflammation, Chronic Active | 2 | 16 2.0|
Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + | 50 |
Inflammation, Chronic Active | 2 | 32 2.2|
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
__________________________________________________________________________|____________|
Testes | + | 50 |
Cyst | | 1 |
Interstitial Cell, Hyperplasia | 2 | 7 1.4|
Seminiferous Tubule, Atrophy | | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + | 50 |
Femoral, Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 49 |
Inflammation, Acute, Necrotizing | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 10 |
Edema | | 4 2.5|
Hemorrhage | | 1 3.0|
Inflammation, Acute, Necrotizing | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + | 50 |
Fibrosis | | 8 2.3|
Hematopoietic Cell Proliferation | | 1 3.0|
Hemorrhage, Chronic | | 1 4.0|
Necrosis | | 3 3.0|
__________________________________________________________________________|____________|
Thymus | M | 40 |
Inflammation, Acute, Necrotizing | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| | |
| 9| 8| 8| 9| 7| 8| 9| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 48 |
Hyperplasia, Cystic | | 25 1.9|
__________________________________________________________________________|____________|
Skin | + | 50 |
Acanthosis | | 2 1.0|
Inflammation, Acute, Necrotizing | | 1 1.0|
Back, Acanthosis | | 6 1.5|
Back, Inflammation, Acute, | | |
Necrotizing | | 1 1.0|
Back, Sebaceous Gland, Hypertrophy | | 4 1.3|
Scapula, Acanthosis | 1 | 39 1.3|
Scapula, Cyst Epithelial Inclusion | | 1 |
Scapula, Hypertrophy | | 2 1.0|
Sebaceous Gland, Hypertrophy | | 1 1.0|
Sebaceous Gland, Scapula, Hypertrophy| | 28 1.1|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 50 |
Cranium, Fibrous Osteodystrophy | | 12 |
Femur, Fibrous Osteodystrophy | | 12 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 50 |
Compression | | 7 |
Infarct | | 2 2.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 50 |
Infarct | | 1 3.0|
Inflammation, Chronic Active | | 15 2.0|
Mineralization | | 7 2.1|
Alveolar Epithelium, Hyperplasia | | 3 1.7|
Artery, Mediastinum, Mineralization | | 6 2.7|
Mediastinum, Inflammation, Chronic | | |
Active | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + | 50 |
Mucosa, Inflammation, Suppurative | | 12 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| | |
| 9| 8| 8| 9| 7| 8| 9| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
50 MG/ML | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mucosa, Thrombosis | | 1 |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 2.5|
__________________________________________________________________________|____________|
Trachea | + | 49 |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Degeneration | | 2 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 50 |
Hydronephrosis | | 1 4.0|
Mineralization | | 7 2.9|
Nephropathy, Chronic | 2 | 49 2.9|
Pelvis, Inflammation, Suppurative | | 5 1.6|
Renal Tubule, Hyperplasia | | 6 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + | 50 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 4| 6| 6| 5| 5| 6| 3| 5| 5| 6| 5| 6| 3| 6| 6| 6| 7| 6| 5| 6| 6|
DAY ON TEST | 1| 0| 2| 9| 4| 8| 1| 9| 7| 1| 9| 9| 0| 4| 6| 9| 5| 6| 0| 3| 1| 6| 9| 5| 2|
| 2| 9| 8| 1| 1| 4| 8| 3| 7| 2| 4| 0| 3| 2| 8| 1| 0| 8| 9| 8| 8| 8| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
100 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MG/ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | |
__________________________________________________________________________|
Intestine Large | + + A + A + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + A + + + A + + + + + + + A + + + + + + A A|
Inflammation, Suppurative | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + A + A + + + A + + + + + + M A + + + + + + A A|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + A + + + + + + + + + + + + + + + + + + A +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + A + A + + + A + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + A + + + A + + + + + + + A + + + + + + + +|
Inflammation, Acute, Necrotizing | |
__________________________________________________________________________|
Intestine Small, Ileum | + + A + A + + + A + + + M + + + A + + + + + + A A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + A + + + A + + + + + + + A + + + + + + A A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X |
Degeneration, Cystic | 2 |
Fatty Change | 1|
Hepatodiaphragmatic Nodule | X |
Inflammation, Acute, Necrotizing | 2 2 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 1 2 1 2 2 1 1|
Centrilobular, Necrosis | 2 2 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Acute, Necrotizing | 2 |
Inflammation, Chronic Active | |
Artery, Mineralization | |
__________________________________________________________________________|
Pancreas | + + A + A + + + A + + + + + + + A + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic Active | |
Acinus, Atrophy | 3 1 3 2 2 2 2 2 1 1 1|
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Mineralization | |
Ulcer | 4 4 2 2 4 |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | 1 |
Mineralization | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 4| 6| 6| 5| 5| 6| 3| 5| 5| 6| 5| 6| 3| 6| 6| 6| 7| 6| 5| 6| 6|
DAY ON TEST | 1| 0| 2| 9| 4| 8| 1| 9| 7| 1| 9| 9| 0| 4| 6| 9| 5| 6| 0| 3| 1| 6| 9| 5| 2|
| 2| 9| 8| 1| 1| 4| 8| 3| 7| 2| 4| 0| 3| 2| 8| 1| 0| 8| 9| 8| 8| 8| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
100 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MG/ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 2 1 2 1 1 2 2 2 2 2 1 1 1 1 1 1 2 2 1 2 2 2 1 2|
Inflammation, Suppurative | |
Mineralization | |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 2 1 1 2 2 1 2 2 2 2 1|
Necrosis | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 1 1 3 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + A + A + + + + + + + + + + + A + + + + + + + +|
Hyperplasia | 2 3 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + A + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 2 3 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + A + + + A + + + + + + + A + + + + + + A A|
C-Cell, Hyperplasia | 2 1 1 1 1 1 1 1 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ductus Deferens | |
Mineralization | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + M + + + +|
Mineralization | |
__________________________________________________________________________|
Penis | + |
Inflammation, Acute, Necrotizing | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic Active | 2 |
Duct, Hyperplasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 1 4 2 2 2 2 2 1 2 1 2 1 1 3 1 4 1 1|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 4| 6| 6| 5| 5| 6| 3| 5| 5| 6| 5| 6| 3| 6| 6| 6| 7| 6| 5| 6| 6|
DAY ON TEST | 1| 0| 2| 9| 4| 8| 1| 9| 7| 1| 9| 9| 0| 4| 6| 9| 5| 6| 0| 3| 1| 6| 9| 5| 2|
| 2| 9| 8| 1| 1| 4| 8| 3| 7| 2| 4| 0| 3| 2| 8| 1| 0| 8| 9| 8| 8| 8| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
100 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MG/ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Interstitial Cell, Hyperplasia | 1 1 1 2 1 1 |
Seminiferous Tubule, Atrophy | 3 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 3 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + |
__________________________________________________________________________|
Spleen | + + + + A + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Amyloid Deposition | |
Fibrosis | 2 2 2 2|
Hematopoietic Cell Proliferation | 3 |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + M I + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + M + + + M M + + + M + + +|
Hyperplasia, Cystic | 2 2 2 3 3 1 2 3 3 3 3 2 2 1 1 2 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Cyst Epithelial Inclusion, Multiple | X |
Inflammation, Acute, Necrotizing | 2 3 |
Back, Acanthosis | 1 2 2 2 1 |
Back, Sebaceous Gland, Hypertrophy | 1 2 2 2 |
Scapula, Acanthosis | 2 2 3 3 1 2 1 2 2 1 3 2 1 2 2 2 2 2 2 2 3|
Scapula, Cyst Epithelial Inclusion | X |
Scapula, Inflammation, Acute, | |
Necrotizing | |
Sebaceous Gland, Hypertrophy | 1 |
Sebaceous Gland, Scapula, Hypertrophy| 2 1 3 3 1 1 1 1 2 1 2 2 2 2 1 2 2 1 1 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | |
Femur, Fibrous Osteodystrophy | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 4| 6| 6| 5| 5| 6| 3| 5| 5| 6| 5| 6| 3| 6| 6| 6| 7| 6| 5| 6| 6|
DAY ON TEST | 1| 0| 2| 9| 4| 8| 1| 9| 7| 1| 9| 9| 0| 4| 6| 9| 5| 6| 0| 3| 1| 6| 9| 5| 2|
| 2| 9| 8| 1| 1| 4| 8| 3| 7| 2| 4| 0| 3| 2| 8| 1| 0| 8| 9| 8| 8| 8| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
100 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MG/ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Infarct | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Inflammation, Chronic Active | |
Mineralization | 1 |
Thrombosis | X |
Pleura, Inflammation, Suppurative | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Suppurative | 2 2 3 3 2 2 2|
Mucosa, Thrombosis | X |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 4 |
Septum, Necrosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + A A|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Degeneration | 3 3 3 3 |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + A + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Nephropathy, Chronic | 2 1 1 3 3 2 1 2 3 1 2 2 3 2 2 1 2 1 2 3 3 2 2 2|
Pelvis, Inflammation, Suppurative | 3 2 2 |
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 2| 5| 5| 6| 5| 7| 5| 7| 7| 6| 5| 6| 6| 6| 5| 6| 6| 6| 7| 7| 5| 5| 4| 7| 6|
DAY ON TEST | 4| 5| 9| 6| 5| 4| 4| 4| 2| 1| 5| 8| 6| 1| 4| 6| 3| 8| 4| 4| 9| 6| 7| 4| 8|
| 2| 0| 5| 8| 8| 0| 3| 3| 5| 3| 0| 6| 2| 2| 8| 5| 5| 7| 3| 4| 1| 8| 8| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
100 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MG/ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | 3 |
__________________________________________________________________________|
Intestine Large | + + A + + + + + + + A + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + A + + + A + + + + + + + A + +|
Inflammation, Suppurative | 2 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + A + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + A + + + A + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Inflammation, Acute, Necrotizing | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + M + A + + + A A + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X|
Degeneration, Cystic | 3 2 |
Fatty Change | 2 |
Hepatodiaphragmatic Nodule | |
Inflammation, Acute, Necrotizing | |
Bile Duct, Cyst | X |
Bile Duct, Hyperplasia | 1 2 1 2 1 1 2 2 2 2 2 1 |
Centrilobular, Necrosis | 2 3 2 2 1 3 |
__________________________________________________________________________|
Mesentery | + + + + +|
Inflammation, Acute, Necrotizing | 4|
Inflammation, Chronic Active | 3 |
Artery, Mineralization | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +|
Inflammation, Acute | 2|
Inflammation, Chronic Active | 1 |
Acinus, Atrophy | 2 1 3 1 1 1 3 1 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + + M|
Inflammation, Chronic Active | 3 |
Mineralization | 3 |
Ulcer | 3 2 1 |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +|
Inflammation, Acute, Necrotizing | 1 3 1 2|
Mineralization | 4 3 3 1 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 2| 5| 5| 6| 5| 7| 5| 7| 7| 6| 5| 6| 6| 6| 5| 6| 6| 6| 7| 7| 5| 5| 4| 7| 6|
DAY ON TEST | 4| 5| 9| 6| 5| 4| 4| 4| 2| 1| 5| 8| 6| 1| 4| 6| 3| 8| 4| 4| 9| 6| 7| 4| 8|
| 2| 0| 5| 8| 8| 0| 3| 3| 5| 3| 0| 6| 2| 2| 8| 5| 5| 7| 3| 4| 1| 8| 8| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
100 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MG/ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Aorta, Mineralization | 3 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 1 1 1 1 3 1 3 2 2 3 1 1 3 2 1 2 2 1 2 2 1 1 2 1|
Inflammation, Suppurative | 2 3 2 |
Mineralization | 3 1 2 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 2 1 2 1 1 1 2 1 2 3 1 1 2 1|
Necrosis | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 2 1 2 2 3 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hyperplasia | 3 3 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + M M + + + + M + + + + + + + + + +|
Hyperplasia | 3 2 3 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + A + + + A + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 2 2 1 1 1 1 1 1|
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ductus Deferens | + |
Mineralization | 3 |
__________________________________________________________________________|
Epididymis | + I + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
__________________________________________________________________________|
Penis | |
Inflammation, Acute, Necrotizing | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
Inflammation, Chronic Active | 3 3 3 1 1 1 3 1 |
Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 3 1 1 3 1 1 2 2 1 2 4 2 1 1 4 1 1 2 1|
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 2| 5| 5| 6| 5| 7| 5| 7| 7| 6| 5| 6| 6| 6| 5| 6| 6| 6| 7| 7| 5| 5| 4| 7| 6|
DAY ON TEST | 4| 5| 9| 6| 5| 4| 4| 4| 2| 1| 5| 8| 6| 1| 4| 6| 3| 8| 4| 4| 9| 6| 7| 4| 8|
| 2| 0| 5| 8| 8| 0| 3| 3| 5| 3| 0| 6| 2| 2| 8| 5| 5| 7| 3| 4| 1| 8| 8| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
100 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MG/ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Interstitial Cell, Hyperplasia | 2 1 2 2 2 1 2 1|
Seminiferous Tubule, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Amyloid Deposition | 3|
Fibrosis | 2 2 2 |
Hematopoietic Cell Proliferation | |
Necrosis | 3 1 3 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + I + + + M + + M + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + M + I + + + + + + + + +|
Hyperplasia, Cystic | 2 2 3 2 2 2 1 3 2 3 2 3 3 1 2 3 3 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Cyst Epithelial Inclusion, Multiple | |
Inflammation, Acute, Necrotizing | |
Back, Acanthosis | 1 2 1 |
Back, Sebaceous Gland, Hypertrophy | 1 1 2 2 |
Scapula, Acanthosis | 2 2 2 2 1 2 2 2 1 2 2 3 3 2 2 1 1 1 2|
Scapula, Cyst Epithelial Inclusion | |
Scapula, Inflammation, Acute, | |
Necrotizing | 2 |
Sebaceous Gland, Hypertrophy | |
Sebaceous Gland, Scapula, Hypertrophy| 1 2 2 1 1 2 2 1 1 2 2 2 2 2 1 1 2 2 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | X X X X |
Femur, Fibrous Osteodystrophy | X X X X |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + M + + + + + + + + + + + + + +|
Compression | X X X X |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
_____________________________________________________________________________________________________________________
| 2| 5| 5| 6| 5| 7| 5| 7| 7| 6| 5| 6| 6| 6| 5| 6| 6| 6| 7| 7| 5| 5| 4| 7| 6|
DAY ON TEST | 4| 5| 9| 6| 5| 4| 4| 4| 2| 1| 5| 8| 6| 1| 4| 6| 3| 8| 4| 4| 9| 6| 7| 4| 8|
| 2| 0| 5| 8| 8| 0| 3| 3| 5| 3| 0| 6| 2| 2| 8| 5| 5| 7| 3| 4| 1| 8| 8| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
100 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MG/ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Infarct | 3 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 |
Inflammation, Chronic Active | 1 |
Mineralization | 2 |
Thrombosis | |
Pleura, Inflammation, Suppurative | 3 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + M + + + + + + + + + + + + + +|
Mucosa, Inflammation, Suppurative | 1 3 1 4 1 1 |
Mucosa, Thrombosis | X X |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 3 |
Septum, Necrosis | 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Degeneration | 2 3 |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 1 1 2 |
Nephropathy, Chronic | 1 2 2 2 3 4 2 2 3 2 2 2 2 3 1 4 4 3 2 4 2 2 2 3 3|
Pelvis, Inflammation, Suppurative | 1 |
Renal Tubule, Hyperplasia | 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 8| 9| 8| 9| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
100 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MG/ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 49 |
Inflammation, Acute, Necrotizing | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | | 44 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 40 |
Inflammation, Suppurative | | 1 2.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 40 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 44 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small | | 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 45 |
Inflammation, Acute, Necrotizing | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 37 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 42 |
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus | | 10 |
Degeneration, Cystic | | 3 2.3|
Fatty Change | | 2 1.5|
Hepatodiaphragmatic Nodule | | 1 |
Inflammation, Acute, Necrotizing | | 2 2.0|
Bile Duct, Cyst | | 1 |
Bile Duct, Hyperplasia | | 19 1.5|
Centrilobular, Necrosis | | 8 2.1|
__________________________________________________________________________|____________|
Mesentery | | 6 |
Inflammation, Acute, Necrotizing | | 2 3.0|
Inflammation, Chronic Active | | 1 3.0|
Artery, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | | 45 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic Active | | 1 1.0|
Acinus, Atrophy | | 19 1.7|
Acinus, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach | | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 47 |
Inflammation, Chronic Active | | 2 2.5|
Mineralization | | 1 3.0|
Ulcer | | 8 2.8|
Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 8| 9| 8| 9| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
100 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MG/ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | | 48 |
Inflammation, Acute, Necrotizing | | 5 1.6|
Mineralization | | 4 2.8|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
Aorta, Mineralization | | 2 3.0|
__________________________________________________________________________|____________|
Heart | | 50 |
Degeneration, Chronic | | 48 1.6|
Inflammation, Suppurative | | 3 2.3|
Mineralization | | 3 2.0|
Atrium, Thrombosis | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Hyperplasia | | 31 1.5|
Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Hyperplasia | | 20 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 46 |
Hyperplasia | | 5 2.6|
__________________________________________________________________________|____________|
Parathyroid Gland | | 45 |
Hyperplasia | | 4 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | | 48 |
Pars Distalis, Hyperplasia | | 11 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | | 43 |
C-Cell, Hyperplasia | | 22 1.1|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ductus Deferens | | 1 |
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Epididymis | | 48 |
Mineralization | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 8| 9| 8| 9| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
100 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MG/ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Penis | | 1 |
Inflammation, Acute, Necrotizing | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | | 50 |
Hyperplasia | | 3 2.7|
Inflammation, Chronic Active | | 9 2.0|
Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | | 50 |
Inflammation, Chronic Active | | 41 1.8|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Testes | | 50 |
Interstitial Cell, Hyperplasia | | 14 1.4|
Seminiferous Tubule, Atrophy | | 4 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | | 49 |
Femoral, Myelofibrosis | | 4 2.8|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
Edema | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 3 |
__________________________________________________________________________|____________|
Spleen | | 49 |
Abscess | | 1 4.0|
Amyloid Deposition | | 1 3.0|
Fibrosis | | 7 2.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Necrosis | | 3 2.3|
__________________________________________________________________________|____________|
Thymus | | 42 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 42 |
Hyperplasia, Cystic | | 36 2.2|
__________________________________________________________________________|____________|
Skin | | 50 |
Acanthosis | | 1 1.0|
Cyst Epithelial Inclusion, Multiple | | 1 |
Inflammation, Acute, Necrotizing | | 2 2.5|
Back, Acanthosis | | 8 1.5|
Back, Sebaceous Gland, Hypertrophy | | 8 1.6|
Scapula, Acanthosis | | 40 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 8| 9| 8| 9| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
100 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MG/ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Scapula, Cyst Epithelial Inclusion | | 1 |
Scapula, Inflammation, Acute, | | |
Necrotizing | | 1 2.0|
Sebaceous Gland, Hypertrophy | | 1 1.0|
Sebaceous Gland, Scapula, Hypertrophy| | 39 1.6|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Cranium, Fibrous Osteodystrophy | | 4 |
Femur, Fibrous Osteodystrophy | | 4 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 49 |
Compression | | 11 |
Infarct | | 3 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Infarct | | 1 3.0|
Inflammation, Chronic Active | | 1 1.0|
Mineralization | | 2 1.5|
Thrombosis | | 1 |
Pleura, Inflammation, Suppurative | | 2 3.5|
__________________________________________________________________________|____________|
Nose | | 49 |
Mucosa, Inflammation, Suppurative | | 13 2.1|
Mucosa, Thrombosis | | 3 |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 4 3.0|
Septum, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Trachea | | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 6 |
Degeneration | | 6 2.8|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05044-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-VINYL-1-CYCLOHEXENE DIEPOXIDE Date: 05/05/97
Route: DERMAL,SOLUTION Time: 07:22:56
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 9| 8| 9| 8| 9| 8| 9| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
100 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MG/ML | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 49 |
Mineralization | | 5 1.8|
Nephropathy, Chronic | | 49 2.2|
Pelvis, Inflammation, Suppurative | | 4 2.0|
Renal Tubule, Hyperplasia | | 4 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
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