TDMS Study 05044-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/06/94
EXP: 05044 4-VINYL-1-CYCLOHEXENE DIEPOXIDE TIME: 11:49:18
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DERMAL,SOLUTION NTP C#: 60139A
CONT: N01-CP-95653 CAS: 106-87-6
PATHOLOGIST: S. GRUMBEIN S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/06/94
EXP: 05044 4-VINYL-1-CYCLOHEXENE DIEPOXIDE TIME: 11:49:18
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DERMAL,SOLUTION NTP C#: 60139A
CONT: N01-CP-95653 CAS: 106-87-6
PATHOLOGIST: S. GRUMBEIN S. EUSTIS
4-VINYL-1-CYCLOHEXENE DIEPOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 743 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/ML |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 43 CENSORED DEATHS 10 TERMINAL 7 |
| |
| UNCENSORED DEATHS |
| 379 458 458 470 504 509 509 525 536 542 |
| 548 548 550 571 582 584 585 591 596 602 |
| 602 607 607 608 619 619 620 647 667 669 |
| 669 673 673 682 682 682 685 690 696 707 |
| 712 730 736 |
| CENSORED DEATHS |
| 458 458 458 458 458 459 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/ML |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 42 CENSORED DEATHS 10 TERMINAL 8 |
| |
| UNCENSORED DEATHS |
| 79 373 387 389 404 427 467 489 538 538 |
| 542 569 571 576 596 609 611 613 626 638 |
| 642 642 647 662 668 674 674 675 676 676 |
| 688 689 689 689 695 704 712 718 722 730 |
| 736 736 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 MG/ ML |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 45 CENSORED DEATHS 11 TERMINAL 4 |
| |
| UNCENSORED DEATHS |
| 242 350 394 441 478 543 548 550 550 558 |
| 568 568 577 590 591 591 593 595 609 609 |
| 612 612 612 613 618 628 629 635 638 642 |
| 659 662 665 668 668 668 684 685 686 687 |
| 691 691 718 725 740 |
| CENSORED DEATHS |
| 458 458 458 458 458 459 459 459 459 459 |
| 503 |
| |
==================================================================================
4-VINYL-1-CYCLOHEXENE DIEPOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 743 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 743 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/ML | 100.0 100.0 100.0 100.0 98.3 93.0 80.9 58.6 44.5 14.1 |
| | |
| | |
|50 MG/ML | 98.3 98.3 98.3 98.3 91.7 88.0 79.8 71.6 53.2 16.4 |
| | |
| | |
|100 MG/ ML | 100.0 100.0 98.3 96.7 95.0 91.3 89.2 64.3 33.2 8.3 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/ML 50 MG/ML 100 MG/ ML |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 14.1% 16.4% 8.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.524 P=0.487N P=0.590 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 603.0 599.7 601.8 |
|NATURAL DEATHS (C) | (12.6) (20.4) (14.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 595.3 595.2 585.7 |
|(STANDARD ERROR) | (13.3) (17.5) (14.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
4-VINYL-1-CYCLOHEXENE DIEPOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 743 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/ML |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 23 CENSORED DEATHS 10 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 226 383 425 586 602 604 609 609 626 635 |
| 646 662 677 698 698 714 715 719 721 725 |
| 725 729 736 |
| CENSORED DEATHS |
| 458 458 458 458 458 459 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/ML |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 27 CENSORED DEATHS 10 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 166 410 471 487 534 542 571 572 584 591 |
| 600 602 608 609 612 613 618 619 625 637 |
| 638 656 661 670 676 718 739 |
| CENSORED DEATHS |
| 458 458 458 458 459 459 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 MG/ ML |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 35 CENSORED DEATHS 10 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| 396 403 404 410 460 494 508 519 524 542 |
| 562 564 601 612 619 620 620 635 640 648 |
| 648 654 661 670 675 676 681 684 689 689 |
| 690 694 695 696 698 |
| CENSORED DEATHS |
| 458 458 458 458 458 459 459 459 459 459 |
| |
==================================================================================
4-VINYL-1-CYCLOHEXENE DIEPOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 743 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 743 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/ML | 100.0 100.0 98.3 98.3 95.0 95.0 95.0 88.9 76.8 54.6 |
| | |
| | |
|50 MG/ML | 100.0 98.3 98.3 98.3 96.7 94.7 88.6 76.5 54.4 46.3 |
| | |
| | |
|100 MG/ ML | 100.0 100.0 100.0 100.0 93.3 91.3 81.2 75.1 54.8 30.4 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/ML 50 MG/ML 100 MG/ ML |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 54.6% 46.3% 30.4% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.007 P=0.262 P=0.005 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 629.1 586.3 599.5 |
|NATURAL DEATHS (C) | (26.4) (21.1) (16.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 651.9 625.1 611.9 |
|(STANDARD ERROR) | (16.5) (16.4) (15.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
4-VINYL-1-CYCLOHEXENE DIEPOXIDE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/ML = 1
50 MG/ML = 2
100 MG/ ML = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1
| 2 3 3 2 123 1
| 3 3 1 1
| 2 2 2 3 13 1 3
90 + 2 2 11 33
| 2 2 1 1
| 2 1 1
| 1133
80 + 113 2
| 33
| 1 12 3
| 121 22
P 70 + 22
E | 1 1
R | 1132 2
C | 2 2
E 60 + 33
N | 11 22
T | 2 2
| 131 22
S 50 + 33 22
U | 1 1
R | 33 1 1
V | 33
I 40 + 3 3 2 2
V | 11
A | 11
L | 33 22
30 + 22
| 3 11 222
| 11 22
| 11 2 2
20 + 33 11 22
| 1 122
| 3 3 111
| 33
10 + 3 3
| 33
|
|
0 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 19 obs hidden.
4-VINYL-1-CYCLOHEXENE DIEPOXIDE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/ML = 1
50 MG/ML = 2
100 MG/ ML = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1 3
| 2 1 1 332 1 2
| 33 1 2 2 1
| 3 3 23 2 1 1
90 + 3 3 22 11
| 3 3 2 2
P | 2 2 1 1
E | 3 3 2 2 11
R 80 + 3 3 22 1 1 1
C | 3 22 1 1
E | 3 3 1 1
N | 223
T 70 + 1 1
| 22 3 11
S | 2233
U | 2233 11
R 60 + 2233
V | 2 2 2 1 11
I | 22 11
V | 22
A 50 + 2 2
L | 33 2 22
| 33
|
40 +
| 33
|
|
30 + 3 3
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 18 obs hidden.
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