TDMS Study 05049-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
DICHLORVOS
NTP Experiment-Test: 05049-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/07/94
Route: GAVAGE Time: 05:32:15
Facility: Southern Research Institute
Chemical CAS #: 62-73-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:32:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 20.0 40.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 15 5 9
Accident 6 5 2
Dead 3 11 5
Survivors
Terminal Sacrifice 25 29 34
Dead 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (48) (50)
Diverticulum 1 (2%)
Necrosis 1 (2%)
Muscularis, Inflammation, Chronic 1 (2%)
Gallbladder (33) (41) (45)
Cyst 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%)
Intestine Large (49) (50) (50)
Cecum, Hyperplasia, Lymphoid 2 (4%)
Cecum, Mucosa, Necrosis 1 (2%)
Intestine Small (46) (49) (48)
Duodenum, Amyloid Deposition 1 (2%)
Duodenum, Hyperplasia, Re Cell 1 (2%)
Ileum, Amyloid Deposition 3 (6%)
Jejunum, Amyloid Deposition 2 (4%)
Jejunum, Fibrosis 1 (2%)
Jejunum, Inflammation, Suppurative 1 (2%)
Jejunum, Necrosis 1 (2%)
Jejunum, Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) 3 (6%)
Jejunum, Peyer's Patch, Hyperplasia,
Mononuclear Cell 1 (2%)
Mucosa, Ileum, Dysplasia 1 (2%)
Submucosa, Ileum, Infiltration Cellular,
Plasma Cell 1 (2%)
Liver (50) (50) (50)
Angiectasis 1 (2%)
Clear Cell Focus 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 8 (16%) 5 (10%) 3 (6%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Inflammation, Chronic 15 (30%) 5 (10%) 13 (26%)
Inflammation, Chronic Active 2 (4%) 3 (6%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:32:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 20.0 40.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Suppurative 1 (2%)
Bile Duct, Cyst 1 (2%) 1 (2%)
Hepatocyte, Cytoplasmic Alteration 1 (2%) 1 (2%)
Hepatocyte, Karyomegaly 1 (2%) 1 (2%) 1 (2%)
Hepatocyte, Necrosis 5 (10%) 8 (16%) 5 (10%)
Hepatocyte, Vacuolization Cytoplasmic 4 (8%) 2 (4%) 4 (8%)
Kupffer Cell, Hyperplasia 3 (6%) 5 (10%) 4 (8%)
Kupffer Cell, Pigmentation 3 (6%)
Mesentery (13) (10) (7)
Inflammation, Chronic 1 (8%) 2 (20%)
Inflammation, Chronic Active 1 (10%)
Inflammation, Suppurative 5 (38%) 2 (20%) 1 (14%)
Artery, Hypertrophy 1 (8%)
Artery, Inflammation, Chronic 2 (15%)
Fat, Inflammation, Chronic Active 1 (14%)
Fat, Mineralization 3 (43%)
Fat, Necrosis, Focal 1 (8%) 1 (10%) 4 (57%)
Pancreas (47) (49) (49)
Atrophy 2 (4%) 1 (2%)
Cytoplasmic Alteration 1 (2%) 1 (2%)
Hyperplasia, Focal 1 (2%)
Infarct 1 (2%)
Inflammation, Chronic 4 (9%) 3 (6%) 1 (2%)
Acinus, Vacuolization Cytoplasmic 1 (2%)
Salivary Glands (49) (50) (50)
Inflammation, Chronic 5 (10%) 6 (12%) 7 (14%)
Inflammation, Suppurative 1 (2%)
Stomach (49) (49) (50)
Forestomach, Cyst 1 (2%)
Forestomach, Diverticulum 1 (2%) 1 (2%)
Forestomach, Erosion 1 (2%)
Forestomach, Foreign Body 1 (2%)
Forestomach, Hyperplasia, Focal 6 (12%) 6 (12%) 5 (10%)
Forestomach, Inflammation, Acute 1 (2%)
Forestomach, Inflammation, Chronic 1 (2%)
Forestomach, Inflammation, Chronic Active 2 (4%) 2 (4%)
Forestomach, Inflammation, Suppurative 2 (4%)
Forestomach, Mineralization 1 (2%)
Forestomach, Mucosa, Hyperplasia, Focal 1 (2%)
Glandular, Atrophy 1 (2%)
Glandular, Cyst 2 (4%)
Glandular, Edema 1 (2%)
Glandular, Erosion 1 (2%)
Glandular, Hemorrhage 1 (2%)
Glandular, Inflammation, Chronic 1 (2%)
Glandular, Inflammation, Suppurative 3 (6%) 1 (2%)
Glandular, Metaplasia, Squamous 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:32:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 20.0 40.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Glandular, Mineralization 5 (10%) 1 (2%)
Glandular, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1) (1)
Inflammation, Chronic, Multiple 1 (100%)
Inflammation, Chronic Active, Multiple 1 (100%)
Aorta, Mineralization 1 (100%)
Heart (50) (50) (50)
Thrombosis 2 (4%)
Artery, Mineralization 1 (2%)
Coronary Artery, Inflammation, Chronic 2 (4%)
Coronary Artery, Media, Hypertrophy 1 (2%)
Endocardium, Inflammation, Chronic Active 1 (2%)
Endocardium, Inflammation, Suppurative 1 (2%)
Myocardium, Angiectasis 1 (2%)
Myocardium, Fibrosis 3 (6%)
Myocardium, Inflammation, Chronic 2 (4%) 1 (2%)
Myocardium, Inflammation, Chronic Active 2 (4%) 1 (2%)
Myocardium, Inflammation, Suppurative 3 (6%)
Myocardium, Mineralization 1 (2%)
Pericardium, Inflammation, Chronic Active 1 (2%)
Pericardium, Inflammation, Suppurative 1 (2%)
Valve, Inflammation, Suppurative 1 (2%)
Ventricle, Embolus Bacterial 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (49) (50)
Hematopoietic Cell Proliferation 2 (4%) 2 (4%)
Cortex, Cyst 1 (2%)
Cortex, Degeneration, Fatty 4 (8%) 2 (4%) 2 (4%)
Cortex, Developmental Malformation 1 (2%) 3 (6%)
Cortex, Hyperplasia, Focal 1 (2%) 1 (2%)
Cortex, Necrosis 1 (2%) 1 (2%)
Cortex, Vacuolization Cytoplasmic 1 (2%)
Medulla, Angiectasis 1 (2%)
Medulla, Vacuolization Cytoplasmic 1 (2%)
Spindle Cell, Hyperplasia 40 (80%) 43 (88%) 48 (96%)
Islets, Pancreatic (46) (49) (49)
Hyperplasia 7 (14%)
Parathyroid Gland (46) (43) (41)
Cyst 3 (7%) 3 (7%)
Ectopic Thymus 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:32:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 20.0 40.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pituitary Gland (45) (45) (44)
Angiectasis 1 (2%) 2 (4%) 6 (14%)
Pars Distalis, Angiectasis 2 (4%) 2 (5%)
Pars Distalis, Cyst 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 13 (29%) 11 (24%) 13 (30%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (49) (48) (50)
Infiltration Cellular, Lymphocyte 2 (4%) 4 (8%) 2 (4%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Ultimobranchial Cyst 1 (2%)
Follicle, Dilatation 6 (12%) 8 (17%) 8 (16%)
Follicle, Hyperplasia 1 (2%)
Follicular Cell, Hyperplasia 5 (10%) 6 (13%) 6 (12%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (7) (2)
Foreign Body 6 (86%) 2 (100%)
Hemorrhage 1 (50%)
Inflammation, Chronic Active 1 (50%)
Inflammation, Suppurative 6 (86%) 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (46) (47) (49)
Amyloid Deposition 1 (2%)
Angiectasis 2 (4%)
Cyst 18 (39%) 16 (34%) 19 (39%)
Hemorrhage 3 (7%) 1 (2%) 7 (14%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 7 (15%) 5 (11%) 2 (4%)
Mineralization 1 (2%)
Oviduct (1) (1)
Inflammation, Chronic 1 (100%)
Uterus (50) (50) (50)
Angiectasis 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Hydrometra 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Cystic 40 (80%) 41 (82%) 45 (90%)
Hyperplasia, Cystic, Multiple 1 (2%)
Hyperplasia, Glandular 1 (2%) 2 (4%)
Inflammation, Chronic 2 (4%) 1 (2%)
Inflammation, Suppurative 8 (16%) 13 (26%) 7 (14%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:32:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 20.0 40.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Endometrium, Edema 1 (2%)
Endometrium, Vacuolization Cytoplasmic 1 (2%)
Mucosa, Metaplasia, Squamous 1 (2%) 2 (4%)
Vagina (1) (1)
Hyperplasia, Squamous 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Hyperplasia 14 (28%) 10 (20%) 2 (4%)
Hyperplasia, Reticulum Cell 1 (2%) 1 (2%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Myelofibrosis 1 (2%)
Lymph Node (48) (49) (49)
Bronchial, Inflammation, Suppurative 1 (2%)
Iliac, Hematopoietic Cell Proliferation 1 (2%)
Iliac, Hyperplasia, Lymphoid 1 (2%)
Iliac, Hyperplasia, Plasma Cell 1 (2%) 3 (6%)
Inguinal, Hyperplasia, Lymphoid 1 (2%)
Lymphatic, Mandibular, Ectasia 1 (2%)
Mandibular, Hyperplasia, Histiocytic 1 (2%)
Mandibular, Hyperplasia, Lymphoid 1 (2%) 2 (4%) 4 (8%)
Mandibular, Hyperplasia, Plasma Cell 3 (6%) 1 (2%) 1 (2%)
Mandibular, Necrosis, Diffuse 1 (2%)
Mandibular, Pigmentation 2 (4%) 3 (6%)
Mediastinal, Angiectasis 1 (2%)
Mediastinal, Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Mediastinal, Hemorrhage 1 (2%)
Mediastinal, Hyperplasia, Histiocytic 1 (2%) 1 (2%) 1 (2%)
Mediastinal, Hyperplasia, Plasma Cell 2 (4%)
Mediastinal, Inflammation, Suppurative 1 (2%)
Mesenteric, Angiectasis 1 (2%) 1 (2%)
Mesenteric, Atrophy 1 (2%)
Mesenteric, Hematopoietic Cell Proliferation 3 (6%) 2 (4%) 1 (2%)
Mesenteric, Hemorrhage 7 (15%) 5 (10%) 4 (8%)
Mesenteric, Hyperplasia, Histiocytic 1 (2%) 1 (2%) 2 (4%)
Mesenteric, Hyperplasia, Lymphoid 2 (4%) 3 (6%)
Mesenteric, Hyperplasia, Plasma Cell 1 (2%) 1 (2%)
Mesenteric, Infiltration Cellular,
Polymorphonuclear 1 (2%)
Mesenteric, Inflammation, Granulomatous 1 (2%)
Mesenteric, Lymphatic, Ectasia 1 (2%)
Pancreatic, Hyperplasia, Lymphoid 2 (4%)
Pancreatic, Necrosis 1 (2%)
Renal, Hematopoietic Cell Proliferation 1 (2%)
Renal, Hyperplasia, Lymphoid 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:32:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 20.0 40.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Renal, Hyperplasia, Plasma Cell 4 (8%) 1 (2%) 1 (2%)
Renal, Inflammation, Suppurative 1 (2%)
Spleen (48) (49) (50)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation Granulocytic 8 (17%) 8 (16%) 2 (4%)
Hematopoietic Cell Proliferation Erythrocytic 9 (19%) 8 (16%) 7 (14%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 4 (8%) 4 (8%) 7 (14%)
Hyperplasia, Megakaryocyte 1 (2%)
Necrosis 1 (2%)
Red Pulp, Pigmentation 1 (2%)
Thymus (41) (43) (45)
Atrophy 2 (5%) 4 (9%) 2 (4%)
Cyst 2 (5%) 3 (7%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Mineralization 1 (2%)
Necrosis, Diffuse 2 (5%)
Medulla, Hyperplasia, Mononuclear Cell 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (48) (49)
Hyperplasia, Cystic 12 (25%) 7 (15%) 9 (18%)
Hyperplasia, Lobular 1 (2%)
Skin (50) (49) (50)
Acanthosis 1 (2%) 2 (4%) 3 (6%)
Exudate 1 (2%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 1 (2%)
Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Hyperostosis 15 (30%) 15 (30%) 14 (28%)
Necrosis 1 (2%)
Cranium, Hyperostosis 1 (2%)
Skeletal Muscle (4) (2) (1)
Inflammation, Chronic 1 (25%)
Inflammation, Chronic Active 1 (50%)
Mineralization 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:32:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 20.0 40.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Cerebellum, Degeneration, Multifocal 1 (2%)
Cerebellum, Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Cerebellum, Infiltration Cellular, Lymphocyte 2 (4%)
Cerebrum, Hemorrhage 1 (2%) 1 (2%)
Cerebrum, Infiltration Cellular, Lymphocyte 1 (2%)
Hippocampus, Necrosis 1 (2%)
Meninges, Infiltration Cellular, Lymphocyte 2 (4%)
Meninges, Infiltration Cellular,
Polymorphonuclear 1 (2%)
Thalamus, Degeneration 1 (2%)
Thalamus, Hemorrhage 1 (2%) 1 (2%)
Thalamus, Infiltration Cellular, Lymphocyte 1 (2%)
Thalamus, Mineralization 24 (48%) 25 (50%) 18 (36%)
Vein, Adventitia, Infiltration Cellular,
Lymphocyte 1 (2%) 1 (2%)
Ventricle, Hydrocephalus 1 (2%)
Ventricle, Mineralization 1 (2%)
Peripheral Nerve (41) (49) (45)
Degeneration 1 (2%) 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Adenomatosis 1 (2%)
Bacterium 1 (2%)
Hemorrhage 1 (2%)
Infiltration Cellular, Histiocyte 2 (4%) 2 (4%) 2 (4%)
Inflammation, Chronic 24 (48%) 17 (34%) 19 (38%)
Inflammation, Suppurative 2 (4%) 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Artery, Inflammation, Suppurative 1 (2%)
Artery, Mineralization 1 (2%)
Interstitium, Edema 3 (6%) 2 (4%)
Pleura, Inflammation, Chronic 1 (2%)
Pleura, Inflammation, Chronic Active 1 (2%)
Pleura, Inflammation, Suppurative 8 (16%) 2 (4%)
Nose (43) (44) (47)
Foreign Body 1 (2%) 4 (9%) 2 (4%)
Fungus 1 (2%) 1 (2%)
Hemorrhage 3 (6%)
Inflammation, Chronic 4 (9%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:32:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 20.0 40.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation, Chronic Active 3 (7%)
Inflammation, Suppurative 26 (60%) 29 (66%) 33 (70%)
Mucosa, Atrophy 1 (2%)
Mucosa, Necrosis 1 (2%)
Submucosa, Hyperplasia, Lymphoid 2 (4%)
Trachea (49) (49) (49)
Foreign Body 2 (4%)
Glands, Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (2)
Middle Ear, Inflammation, Suppurative 2 (100%)
Harderian Gland (3) (3) (3)
Infiltration Cellular, Lymphocyte 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50)
Casts 12 (24%) 10 (20%) 7 (14%)
Cyst 1 (2%) 2 (4%)
Glomerulosclerosis 1 (2%) 2 (4%)
Hydronephrosis 1 (2%)
Infarct 1 (2%) 2 (4%)
Inflammation, Chronic 30 (61%) 24 (48%) 26 (52%)
Inflammation, Suppurative 1 (2%) 2 (4%) 1 (2%)
Metaplasia, Osseous 2 (4%) 3 (6%) 1 (2%)
Pigmentation 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Artery, Media, Hypertrophy 1 (2%)
Glomerulus, Inflammation, Chronic Active 1 (2%)
Renal Tubule, Atrophy 3 (6%) 1 (2%) 5 (10%)
Renal Tubule, Degeneration 1 (2%)
Renal Tubule, Dilatation 1 (2%)
Renal Tubule, Mineralization 2 (4%)
Renal Tubule, Regeneration 8 (16%) 5 (10%) 6 (12%)
Urinary Bladder (44) (45) (49)
Edema 1 (2%)
Inflammation, Chronic 19 (43%) 13 (29%) 13 (27%)
Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:32:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 10.0 20.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 9 6 8
Moribund 5 17 13
Accident 1
Survivors
Terminal Sacrifice 35 27 29
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (40) (35) (37)
Amyloid Deposition 1 (3%)
Concretion 2 (5%)
Hemorrhage 1 (3%)
Inflammation, Suppurative 1 (3%) 1 (3%)
Intestine Large (49) (50) (49)
Cecum, Hyperplasia, Lymphoid 2 (4%)
Cecum, Mucosa, Fibrosis 1 (2%)
Cecum, Serosa, Ectopic Tissue 1 (2%)
Intestine Small (48) (50) (49)
Duodenum, Ulcer 1 (2%)
Ileum, Peyer's Patch, Hyperplasia, Lymphoid 3 (6%) 2 (4%) 3 (6%)
Mucosa, Ileum, Dysplasia 1 (2%)
Serosa, Jejunum, Cyst 1 (2%)
Serosa, Jejunum, Inflammation, Granulomatous 1 (2%)
Liver (50) (50) (50)
Amyloid Deposition 1 (2%)
Angiectasis 1 (2%)
Clear Cell Focus 2 (4%) 1 (2%) 2 (4%)
Eosinophilic Focus 1 (2%)
Hematopoietic Cell Proliferation 3 (6%) 3 (6%) 4 (8%)
Hyperplasia, Focal 1 (2%)
Inflammation, Chronic 2 (4%) 3 (6%) 5 (10%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
Bile Duct, Cyst 1 (2%)
Hepatocyte, Anisokaryosis 1 (2%)
Hepatocyte, Cytomegaly 2 (4%)
Hepatocyte, Cytoplasmic Alteration 2 (4%)
Hepatocyte, Karyomegaly 3 (6%) 2 (4%) 2 (4%)
Hepatocyte, Necrosis 3 (6%) 4 (8%) 3 (6%)
Hepatocyte, Vacuolization Cytoplasmic 7 (14%) 6 (12%) 10 (20%)
Kupffer Cell, Hyperplasia 3 (6%) 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:32:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 10.0 20.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Kupffer Cell, Pigmentation 3 (6%) 1 (2%)
Vein, Thrombosis 1 (2%)
Vein, Adventitia, Fibrosis 1 (2%)
Mesentery (5) (6) (8)
Fibrosis 1 (13%)
Hemorrhage 1 (17%)
Inflammation, Suppurative 1 (20%)
Mineralization 1 (17%) 1 (13%)
Artery, Inflammation, Chronic 1 (13%)
Artery, Necrosis 1 (17%)
Artery, Thrombosis 1 (17%)
Fat, Necrosis, Focal 1 (20%) 3 (50%) 3 (38%)
Pancreas (50) (48) (48)
Atrophy 1 (2%) 1 (2%)
Atypia Cellular, Focal 1 (2%)
Cyst 2 (4%)
Hyperplasia, Focal 1 (2%)
Inflammation, Chronic 1 (2%) 2 (4%) 2 (4%)
Inflammation, Suppurative 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Salivary Glands (50) (50) (50)
Inflammation, Chronic 13 (26%) 8 (16%) 8 (16%)
Stomach (50) (50) (50)
Forestomach, Cyst 1 (2%)
Forestomach, Hyperplasia 10 (20%) 5 (10%) 9 (18%)
Forestomach, Inflammation, Chronic 3 (6%) 1 (2%) 1 (2%)
Forestomach, Inflammation, Chronic Active 4 (8%) 2 (4%) 2 (4%)
Forestomach, Inflammation, Suppurative 1 (2%)
Forestomach, Mineralization 1 (2%) 1 (2%)
Forestomach, Ulcer 2 (4%)
Forestomach, Mucosa, Hyperplasia 1 (2%)
Glandular, Cyst 1 (2%) 1 (2%)
Glandular, Dysplasia 2 (4%)
Glandular, Erosion 2 (4%)
Glandular, Inflammation, Chronic Active 1 (2%)
Glandular, Inflammation, Suppurative 3 (6%) 2 (4%)
Glandular, Metaplasia, Squamous 1 (2%)
Glandular, Mineralization 2 (4%) 3 (6%) 3 (6%)
Tooth (7) (10) (4)
Developmental Malformation 4 (57%) 10 (100%) 3 (75%)
Foreign Body 1 (10%)
Peridontal Tissue, Fibrosis 1 (14%)
Peridontal Tissue, Inflammation, Chronic
Active 2 (29%) 1 (10%)
Peridontal Tissue, Inflammation, Suppurative 1 (14%) 2 (20%)
Pulp, Inflammation, Suppurative 2 (20%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:32:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 10.0 20.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (3) (1)
Inflammation, Chronic Active 1 (33%) 1 (100%)
Aorta, Embolus Bacterial 2 (67%)
Aorta, Inflammation, Chronic Active 1 (33%)
Heart (50) (50) (50)
Embolus Bacterial 1 (2%)
Thrombosis 1 (2%)
Coronary Artery, Inflammation, Chronic 2 (4%) 1 (2%)
Coronary Artery, Inflammation, Chronic Active 1 (2%)
Coronary Artery, Inflammation, Suppurative 1 (2%)
Coronary Artery, Necrosis, Fibrinoid 1 (2%)
Endocardium, Inflammation, Chronic 1 (2%)
Epicardium, Fibrosis 1 (2%)
Epicardium, Inflammation, Chronic 1 (2%)
Myocardium, Fibrosis 1 (2%)
Myocardium, Inflammation, Chronic 1 (2%) 2 (4%)
Myocardium, Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (48) (50) (49)
Developmental Malformation 1 (2%) 1 (2%) 2 (4%)
Cortex, Atrophy 1 (2%)
Cortex, Hyperplasia 1 (2%)
Cortex, Hyperplasia, Focal 2 (4%) 4 (8%) 1 (2%)
Cortex, Infiltration Cellular, Lymphocyte 1 (2%)
Cortex, Vacuolization Cytoplasmic 2 (4%)
Medulla, Hyperplasia 2 (4%) 1 (2%) 2 (4%)
Spindle Cell, Hyperplasia 27 (56%) 27 (54%) 21 (43%)
Islets, Pancreatic (50) (47) (48)
Dysplasia 1 (2%)
Hyperplasia 15 (30%) 13 (28%) 7 (15%)
Infiltration Cellular, Lymphocyte 1 (2%)
Parathyroid Gland (28) (40) (43)
Crystals 1 (2%)
Cyst 1 (3%) 2 (5%)
Infiltration Cellular, Lymphocyte 1 (4%) 1 (2%)
Pituitary Gland (40) (44) (40)
Pars Distalis, Cyst 3 (8%) 4 (9%)
Pars Distalis, Hyperplasia 2 (5%) 1 (3%)
Thyroid Gland (45) (50) (49)
Infiltration Cellular, Lymphocyte 1 (2%)
Mineralization 1 (2%)
Follicle, Crystals 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:32:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 10.0 20.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Follicle, Dilatation 5 (11%) 3 (6%) 3 (6%)
Follicular Cell, Hyperplasia 4 (9%) 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2) (2) (1)
Foreign Body 1 (50%)
Hemorrhage 1 (50%) 1 (50%)
Inflammation, Suppurative 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (2) (1)
Dilatation 1 (50%) 1 (100%)
Epididymis (50) (49) (49)
Fibrosis 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Preputial Gland (20) (14) (11)
Ectasia 14 (70%) 12 (86%) 5 (45%)
Inflammation, Chronic 10 (50%) 6 (43%) 7 (64%)
Inflammation, Chronic Active 1 (5%)
Inflammation, Suppurative 9 (45%) 3 (21%) 5 (45%)
Prostate (47) (49) (49)
Dilatation 1 (2%)
Inflammation, Chronic 7 (15%) 4 (8%) 2 (4%)
Inflammation, Suppurative 4 (9%) 3 (6%) 1 (2%)
Seminal Vesicle (5) (5) (5)
Amyloid Deposition 1 (20%)
Dilatation 1 (20%) 1 (20%)
Fibrosis 2 (40%) 1 (20%) 2 (40%)
Inflammation, Chronic 1 (20%) 1 (20%)
Inflammation, Chronic Active 1 (20%)
Inflammation, Suppurative 2 (40%) 3 (60%)
Pigmentation 1 (20%)
Testes (50) (50) (49)
Artery, Mineralization 1 (2%)
Seminiferous Tubule, Atrophy 3 (6%) 7 (14%) 2 (4%)
Seminiferous Tubule, Mineralization 4 (8%) 4 (8%) 3 (6%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:32:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 10.0 20.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Congestion 1 (2%)
Hyperplasia 9 (18%) 7 (14%) 10 (20%)
Hyperplasia, Histiocytic 1 (2%)
Pigmentation 1 (2%)
Lymph Node (47) (48) (50)
Iliac, Hyperplasia, Plasma Cell 1 (2%)
Inguinal, Fibrosis 1 (2%)
Inguinal, Hyperplasia, Histiocytic 2 (4%) 1 (2%) 2 (4%)
Inguinal, Hyperplasia, Plasma Cell 1 (2%) 2 (4%)
Inguinal, Infiltration Cellular,
Polymorphonuclear 1 (2%)
Inguinal, Pigmentation 4 (8%) 4 (8%)
Lymphatic, Mandibular, Ectasia 1 (2%)
Mandibular, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Mandibular, Hyperplasia, Plasma Cell 1 (2%) 2 (4%) 5 (10%)
Mandibular, Pigmentation 2 (4%)
Mesenteric, Angiectasis 2 (4%) 1 (2%)
Mesenteric, Atrophy 1 (2%) 1 (2%) 1 (2%)
Mesenteric, Congestion 1 (2%)
Mesenteric, Hematopoietic Cell Proliferation 4 (9%) 6 (13%) 4 (8%)
Mesenteric, Hemorrhage 19 (40%) 14 (29%) 14 (28%)
Mesenteric, Hyperplasia, Histiocytic 1 (2%) 1 (2%)
Mesenteric, Hyperplasia, Lymphoid 1 (2%) 3 (6%)
Mesenteric, Hyperplasia, Plasma Cell 1 (2%) 1 (2%)
Mesenteric, Infiltration Cellular, Mast Cell 1 (2%)
Mesenteric, Infiltration Cellular,
Megakaryocyte 1 (2%)
Mesenteric, Infiltration Cellular,
Polymorphonuclear 1 (2%)
Mesenteric, Lymphatic, Ectasia 2 (4%)
Renal, Hemorrhage 1 (2%)
Renal, Hyperplasia, Histiocytic 1 (2%)
Renal, Hyperplasia, Plasma Cell 1 (2%)
Renal, Lymphatic, Ectasia 1 (2%)
Spleen (49) (49) (49)
Hematopoietic Cell Proliferation Granulocytic 2 (4%) 4 (8%) 5 (10%)
Hematopoietic Cell Proliferation Erythrocytic 10 (20%) 10 (20%) 9 (18%)
Hyperplasia, Lymphoid 2 (4%) 3 (6%) 1 (2%)
Hyperplasia, Megakaryocyte 1 (2%)
Hyperplasia, Plasma Cell 1 (2%)
Necrosis, Focal 1 (2%)
Lymphoid Follicle, Atrophy 1 (2%)
Thymus (35) (32) (36)
Atrophy 1 (3%)
Cyst 3 (9%) 7 (22%) 7 (19%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:32:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 10.0 20.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (49) (50)
Acanthosis 12 (24%) 16 (33%) 17 (34%)
Acanthosis, Multiple 1 (2%)
Edema 3 (6%) 1 (2%)
Erosion 2 (4%)
Exudate 1 (2%) 1 (2%) 2 (4%)
Fibrosis 3 (6%) 3 (6%) 1 (2%)
Foreign Body 1 (2%)
Fungus 1 (2%) 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Chronic 4 (8%) 7 (14%) 7 (14%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 3 (6%)
Inflammation, Chronic Active, Multiple 1 (2%)
Inflammation, Granulomatous 2 (4%) 2 (4%)
Inflammation, Suppurative 1 (2%) 3 (6%) 1 (2%)
Ulcer 1 (2%) 2 (4%) 6 (12%)
Lymphatic, Angiectasis 1 (2%)
Sebaceous Gland, Hyperplasia 1 (2%)
Subcutaneous Tissue, Fibrosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (47)
Dysplasia 2 (4%)
Necrosis 1 (2%) 1 (2%)
Proliferation 1 (2%)
Skeletal Muscle (5) (1) (4)
Foreign Body 1 (25%)
Hemorrhage 1 (25%)
Inflammation, Chronic 2 (40%) 1 (100%) 1 (25%)
Inflammation, Chronic Active 1 (20%)
Inflammation, Granulomatous 1 (25%)
Inflammation, Suppurative 2 (40%) 1 (25%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Cerebrum, Vacuolization Cytoplasmic 1 (2%)
Hippocampus, Infiltration Cellular,
Lymphocyte 1 (2%)
Thalamus, Mineralization 20 (40%) 26 (52%) 25 (50%)
Venule, Infiltration Cellular, Lymphocyte 1 (2%)
Peripheral Nerve (40) (50) (42)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:32:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 10.0 20.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Degeneration 1 (2%) 1 (2%)
Inflammation, Chronic 1 (3%) 2 (5%)
Inflammation, Subacute 4 (10%) 2 (5%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Hemorrhage 1 (2%) 3 (6%)
Infiltration Cellular, Eosinophil 1 (2%)
Infiltration Cellular, Histiocyte 3 (6%) 8 (16%) 5 (10%)
Inflammation, Chronic 27 (54%) 10 (20%) 17 (34%)
Inflammation, Suppurative 1 (2%) 2 (4%) 9 (18%)
Thrombosis 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 4 (8%)
Artery, Mineralization 1 (2%)
Bronchus, Foreign Body 1 (2%)
Capillary, Infiltration Cellular,
Polymorphonuclear 1 (2%)
Glands, Ectasia 1 (2%)
Interstitium, Edema 4 (8%) 4 (8%) 3 (6%)
Pleura, Inflammation, Suppurative 1 (2%)
Nose (46) (50) (48)
Fungus 2 (4%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 16 (35%) 5 (10%) 16 (33%)
Glands, Cyst 1 (2%)
Mucosa, Metaplasia, Squamous 1 (2%)
Trachea (49) (50) (49)
Hemorrhage 1 (2%)
Submucosa, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Cornea, Hyperplasia 1 (100%)
Cornea, Inflammation, Chronic Active 1 (100%)
Harderian Gland (6) (3) (8)
Cyst 1 (13%)
Inflammation, Chronic 1 (17%) 1 (13%)
Lacrimal Gland (1)
Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:32:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 10.0 20.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Amyloid Deposition 1 (2%)
Bacterium 1 (2%) 1 (2%)
Calculus Micro Observation Only 1 (2%)
Casts 5 (10%) 11 (22%) 5 (10%)
Congestion 1 (2%)
Cyst 3 (6%) 8 (16%) 2 (4%)
Glomerulosclerosis 4 (8%) 3 (6%)
Hydronephrosis 1 (2%) 1 (2%)
Infarct 1 (2%) 1 (2%)
Inflammation, Chronic 29 (58%) 27 (54%) 26 (52%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 3 (6%) 2 (4%) 3 (6%)
Metaplasia, Osseous 1 (2%) 2 (4%)
Cortex, Necrosis 1 (2%)
Renal Tubule, Atrophy 2 (4%) 4 (8%) 4 (8%)
Renal Tubule, Degeneration 1 (2%)
Renal Tubule, Dilatation 2 (4%)
Renal Tubule, Mineralization 2 (4%) 3 (6%) 1 (2%)
Renal Tubule, Regeneration 26 (52%) 24 (48%) 22 (44%)
Renal Tubule, Vacuolization Cytoplasmic 1 (2%)
Urethra (2)
Angiectasis 1 (50%)
Inflammation, Chronic Active 1 (50%)
Inflammation, Suppurative 1 (50%)
Urinary Bladder (50) (48) (49)
Angiectasis 1 (2%)
Calculus Gross Observation 1 (2%)
Calculus Micro Observation Only 2 (4%)
Edema 1 (2%)
Fibrosis 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic 4 (8%) 4 (8%) 2 (4%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Mineralization 1 (2%)
Mucosa, Hyperplasia 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
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