TDMS Study 05049-02 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
DICHLORVOS
NTP Experiment-Test: 05049-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/07/94
Route: GAVAGE Time: 05:40:06
Facility: Southern Research Institute
Chemical CAS #: 62-73-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:40:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 20.0 40.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund 15 5 9
Accident 6 5 2
Dead 3 11 5
Survivors
Terminal Sacrifice 25 29 34
Dead 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large (49) (50) (50)
Intestine Small (46) (49) (48)
Jejunum, Fibrous Histiocytoma 1 (2%)
Liver (50) (50) (50)
Fibrous Histiocytoma 1 (2%)
Hemangiosarcoma, Multiple 1 (2%)
Hepatocellular Carcinoma 4 (8%) 3 (6%) 3 (6%)
Hepatocellular Adenoma 2 (4%) 1 (2%) 4 (8%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Mesentery (13) (10) (7)
Fibrous Histiocytoma, Multiple 1 (8%)
Pancreas (47) (49) (49)
Adenoma 1 (2%)
Fibrous Histiocytoma 1 (2%)
Salivary Glands (49) (50) (50)
Stomach (49) (49) (50)
Fibrous Histiocytoma 1 (2%)
Forestomach, Squamous Cell Carcinoma 2 (4%)
Forestomach, Squamous Cell Papilloma 5 (10%) 6 (12%) 18 (36%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:40:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 20.0 40.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (49) (50)
Medulla, Pheochromocytoma Benign 4 (8%) 1 (2%)
Islets, Pancreatic (46) (49) (49)
Adenoma 1 (2%)
Pituitary Gland (45) (45) (44)
Pars Distalis, Adenoma 11 (24%) 6 (13%) 6 (14%)
Pars Distalis, Carcinoma 1 (2%)
Pars Intermedia, Adenoma 2 (4%) 1 (2%)
Thyroid Gland (49) (48) (50)
Follicular Cell, Adenocarcinoma 1 (2%)
Follicular Cell, Adenoma 3 (6%) 4 (8%) 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (7) (2)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (46) (47) (49)
Cystadenoma 2 (4%)
Oviduct (1) (1)
Uterus (50) (50) (50)
Carcinoma 1 (2%)
Hemangiosarcoma 1 (2%)
Leiomyosarcoma 1 (2%)
Polyp Stromal 2 (4%)
Sarcoma Stromal 1 (2%) 1 (2%)
Vagina (1) (1)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Hemangiosarcoma 1 (2%) 1 (2%)
Lymph Node (48) (49) (49)
Adenocarcinoma, Metastatic, Thyroid Gland 1 (2%)
Spleen (48) (49) (50)
Hemangiosarcoma 1 (2%)
Thymus (41) (43) (45)
Fibrous Histiocytoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:40:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 20.0 40.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (48) (49)
Adenocarcinoma 2 (4%)
Skin (50) (49) (50)
Sebaceous Gland, Adenoma 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Hemangiosarcoma 1 (2%)
Osteosarcoma 1 (2%) 1 (2%)
Skeletal Muscle (4) (2) (1)
Fibrous Histiocytoma 1 (25%)
Hemangiosarcoma 1 (25%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Meningioma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 3 (6%) 5 (10%)
Alveolar/Bronchiolar Carcinoma 2 (4%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%) 1 (2%)
Nose (43) (44) (47)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3) (3) (3)
Adenoma 1 (33%) 3 (100%) 3 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50)
Ureter (1)
Urinary Bladder (44) (45) (49)
Page 4
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:40:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 20.0 40.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Lymphoma Malignant Histiocytic 2 (4%) 2 (4%)
Lymphoma Malignant Lymphocytic 5 (10%) 2 (4%)
Lymphoma Malignant Mixed 8 (16%) 9 (18%) 7 (14%)
Lymphoma Malignant Undifferentiated Cell 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:40:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 20.0 40.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 37 26 37
Total Primary Neoplasms 73 40 68
Total Animals with Benign Neoplasms 26 17 32
Total Benign Neoplasms 34 25 43
Total Animals with Malignant Neoplasms 24 15 18
Total Malignant Neoplasms 39 15 25
Total Animals with Metastatic Neoplasms 1 1 1
Total Metastatic Neoplasm 1 1 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:40:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 10.0 20.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Dead 9 6 8
Moribund 5 17 13
Accident 1
Survivors
Terminal Sacrifice 35 27 29
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large (49) (50) (49)
Cecum, Carcinoma 1 (2%)
Intestine Small (48) (50) (49)
Duodenum, Adenocarcinoma 1 (2%) 1 (2%) 1 (2%)
Duodenum, Polyp Adenomatous 1 (2%)
Jejunum, Adenocarcinoma 1 (2%)
Liver (50) (50) (50)
Hemangiosarcoma 1 (2%)
Hemangiosarcoma, Multiple 2 (4%)
Hepatocellular Carcinoma 7 (14%) 13 (26%) 8 (16%)
Hepatocellular Carcinoma, Multiple 3 (6%) 3 (6%) 2 (4%)
Hepatocellular Adenoma 5 (10%) 3 (6%) 8 (16%)
Hepatocellular Adenoma, Multiple 2 (4%) 3 (6%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 1 (2%)
Mesentery (5) (6) (8)
Hemangioma 1 (20%)
Hemangiosarcoma 1 (17%)
Pancreas (50) (48) (48)
Salivary Glands (50) (50) (50)
Stomach (50) (50) (50)
Forestomach, Squamous Cell Papilloma 1 (2%) 5 (10%)
Forestomach, Squamous Cell Papilloma,
Multiple 1 (2%)
Glandular, Carcinoid Tumor Malignant 1 (2%)
Tooth (7) (10) (4)
Neoplasm NOS 1 (25%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:40:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 10.0 20.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (48) (50) (49)
Cortex, Adenoma 1 (2%)
Medulla, Pheochromocytoma Malignant 1 (2%)
Medulla, Pheochromocytoma Benign 2 (4%) 5 (10%) 1 (2%)
Islets, Pancreatic (50) (47) (48)
Pituitary Gland (40) (44) (40)
Pars Distalis, Adenoma 1 (2%) 1 (3%)
Thyroid Gland (45) (50) (49)
Follicular Cell, Adenoma 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (49) (49)
Preputial Gland (20) (14) (11)
Hemangiosarcoma 1 (5%)
Testes (50) (50) (49)
Interstitial Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Hemangiosarcoma 2 (4%)
Lymph Node (47) (48) (50)
Mandibular, Sarcoma 1 (2%) 1 (2%)
Spleen (49) (49) (49)
Hemangiosarcoma 1 (2%)
Thymus (35) (32) (36)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:40:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 10.0 20.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (49) (50)
Basal Cell Carcinoma 1 (2%)
Keratoacanthoma, Multiple 1 (2%)
Papilloma 1 (2%)
Plasma Cell Tumor Malignant 1 (2%)
Subcutaneous Tissue, Fibroma 4 (8%) 2 (4%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 4 (8%) 4 (8%)
Subcutaneous Tissue, Fibrosarcoma, Multiple 4 (8%) 4 (8%) 3 (6%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%) 2 (4%)
Subcutaneous Tissue, Sarcoma, Multiple 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant,
Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 9 (18%) 13 (26%) 8 (16%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) 2 (4%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Hepatocellular Carcinoma, Metastatic 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 3 (6%) 1 (2%) 3 (6%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 1 (2%)
Sarcoma 1 (2%)
Nose (46) (50) (48)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:40:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 10.0 20.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (6) (3) (8)
Adenoma 5 (83%) 3 (100%) 5 (63%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Sarcoma 1 (2%)
Urinary Bladder (50) (48) (49)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Lymphoma Malignant Histiocytic 1 (2%)
Lymphoma Malignant Lymphocytic 1 (2%) 1 (2%) 1 (2%)
Lymphoma Malignant Mixed 6 (12%) 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05049-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 05:40:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 10.0 20.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 37 41 37
Total Primary Neoplasms 60 77 68
Total Animals with Benign Neoplasms 24 26 28
Total Benign Neoplasms 30 32 38
Total Animals with Malignant Neoplasms 24 31 23
Total Malignant Neoplasms 30 45 29
Total Animals with Metastatic Neoplasms 4 1 4
Total Metastatic Neoplasm 4 1 5
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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