TDMS Study 05049-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst DICHLORVOS DATE: 09/07/94
EXPERIMENT: 05049 TEST: 02 TIME: 05:49:49
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-28024 ROUTE: GAVAGE NTP C#: 00113B
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 62-73-7
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst DICHLORVOS DATE: 09/07/94
EXPERIMENT: 05049 TEST: 02 TIME: 05:49:49
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-28024 ROUTE: GAVAGE NTP C#: 00113B
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 62-73-7
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst DICHLORVOS DATE: 09/07/94
EXPERIMENT: 05049 TEST: 02 TIME: 05:49:49
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-28024 ROUTE: GAVAGE NTP C#: 00113B
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 62-73-7
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF DICHLORVOS
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Skin: Subcutaneous Tissue Fibroma
Stomach, Forestomach Squamous Cell Carcinoma or Papilloma Squamous
Squamous Cell Papilloma
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Stomach, Forestomach Squamous Cell Carcinoma or Papilloma Squamous
Squamous Cell Papilloma
All Organs Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.0 20.0 | VEHICLE 20.0 40.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/48 (4%) 5/50 (10%) 1/49 (2%) | 4/50 (8%) 1/49 (2%) 0/50 (0%) |
|ADJUSTED (b) | 6.1% 12.7% 2.4% | 14.8% 3.4% 0.0% |
|TERMINAL (d) | 2/33 (6%) 1/27 (4%) 0/29 (0%) | 3/26 (12%) 1/29 (3%) 0/34 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 559 578 | 724 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.445N P=0.201 P=0.527N | P=0.014N* P=0.151N P=0.036N* |
|INCIDENTAL TUMOR | P=0.234N P=0.395 P=0.425N | P=0.018N* P=0.170N P=0.045N* |
|LOGISTIC REGRESSION | P=0.405N P=0.226 P=0.492N | P=0.015N* P=0.158N P=0.036N* |
|COCHRAN-ARMITAGE | P=0.402N | P=0.026N* |
|FISHER EXACT | P=0.235 P=0.492N | P=0.187N P=0.059N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/48 (4%) 5/50 (10%) 2/49 (4%) | 4/50 (8%) 1/49 (2%) 0/50 (0%) |
|ADJUSTED (b) | 6.1% 12.7% 5.7% | 14.8% 3.4% 0.0% |
|TERMINAL (d) | 2/33 (6%) 1/27 (4%) 1/29 (3%) | 3/26 (12%) 1/29 (3%) 0/34 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 559 578 | 724 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.545 P=0.201 P=0.661 | P=0.014N* P=0.151N P=0.036N* |
|INCIDENTAL TUMOR | P=0.418N P=0.395 P=0.652N | P=0.018N* P=0.170N P=0.045N* |
|LOGISTIC REGRESSION | P=0.574N P=0.226 P=0.691N | P=0.015N* P=0.158N P=0.036N* |
|COCHRAN-ARMITAGE | P=0.574N | P=0.026N* |
|FISHER EXACT | P=0.235 P=0.684N | P=0.187N P=0.059N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.0 20.0 | VEHICLE 20.0 40.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 5.4% 0.0% | 3.8% 0.0% 2.1% |
|TERMINAL (d) | 0/35 (0%) 0/27 (0%) 0/29 (0%) | 1/26 (4%) 0/29 (0%) 0/34 (0%) |
|FIRST INCIDENCE (DAYS) | --- 624 --- | 729 (T) --- 520 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.638 P=0.236 (e) | P=0.626N P=0.478N P=0.718N |
|INCIDENTAL TUMOR | P=0.592N P=0.500 (e) | P=0.591N P=0.478N P=0.684N |
|LOGISTIC REGRESSION | P=0.667 P=0.225 (e) | P=0.668 P=0.478N P=0.761 |
|COCHRAN-ARMITAGE | P=0.669 | P=0.669N |
|FISHER EXACT | P=0.247 (e) | P=0.500N P=0.753N |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 3/50 (6%) 5/50 (10%) | 1/50 (2%) 3/50 (6%) 3/50 (6%) |
|ADJUSTED (b) | 13.4% 9.8% 14.6% | 3.8% 10.3% 7.2% |
|TERMINAL (d) | 4/35 (11%) 1/27 (4%) 3/29 (10%) | 1/26 (4%) 3/29 (10%) 1/34 (3%) |
|FIRST INCIDENCE (DAYS) | 541 694 578 | 729 (T) 729 (T) 534 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.483 P=0.464N P=0.548 | P=0.329 P=0.344 P=0.385 |
|INCIDENTAL TUMOR | P=0.566N P=0.274N P=0.602N | P=0.299 P=0.344 P=0.328 |
|LOGISTIC REGRESSION | P=0.564 P=0.337N P=0.627 | P=0.272 P=0.344 P=0.313 |
|COCHRAN-ARMITAGE | P=0.571N | P=0.238 |
|FISHER EXACT | P=0.357N P=0.630N | P=0.309 P=0.309 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.0 20.0 | VEHICLE 20.0 40.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Intestine Small |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.9% 7.4% 3.4% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/35 (3%) 2/27 (7%) 1/29 (3%) | 0/26 (0%) 0/29 (0%) 0/34 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 729 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.557 P=0.409 P=0.720 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.557 P=0.409 P=0.720 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.557 P=0.409 P=0.720 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.622N | (e) |
|FISHER EXACT | P=0.500 P=0.753N | (e) (e) |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.9% 4.5% 0.0% | 3.8% 0.0% 0.0% |
|TERMINAL (d) | 1/35 (3%) 0/27 (0%) 0/29 (0%) | 1/26 (4%) 0/29 (0%) 0/34 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 514 --- | 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.386N P=0.486 P=0.538N | P=0.235N P=0.478N P=0.446N |
|INCIDENTAL TUMOR | P=0.305N P=0.515 P=0.538N | P=0.235N P=0.478N P=0.446N |
|LOGISTIC REGRESSION | P=0.368N P=0.463 P=0.538N | P=0.235N P=0.478N P=0.446N |
|COCHRAN-ARMITAGE | P=0.360N | P=0.269N |
|FISHER EXACT | P=0.500 P=0.500N | P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.0 20.0 | VEHICLE 20.0 40.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 3/50 (6%) 11/50 (22%) | 2/50 (4%) 1/50 (2%) 4/50 (8%) |
|ADJUSTED (b) | 20.0% 11.1% 36.0% | 7.2% 3.4% 10.9% |
|TERMINAL (d) | 7/35 (20%) 3/27 (11%) 10/29 (34%) | 1/26 (4%) 1/29 (3%) 3/34 (9%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 578 | 707 729 (T) 624 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.080 P=0.277N P=0.107 | P=0.337 P=0.475N P=0.459 |
|INCIDENTAL TUMOR | P=0.092 P=0.277N P=0.128 | P=0.269 P=0.508N P=0.357 |
|LOGISTIC REGRESSION | P=0.093 P=0.277N P=0.134 | P=0.295 P=0.489N P=0.401 |
|COCHRAN-ARMITAGE | P=0.157 | P=0.238 |
|FISHER EXACT | P=0.159N P=0.218 | P=0.500N P=0.339 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 16/50 (32%) 10/50 (20%) | 4/50 (8%) 3/50 (6%) 3/50 (6%) |
|ADJUSTED (b) | 25.9% 40.0% 25.1% | 12.7% 9.1% 7.5% |
|TERMINAL (d) | 7/35 (20%) 6/27 (22%) 3/29 (10%) | 2/26 (8%) 2/29 (7%) 0/34 (0%) |
|FIRST INCIDENCE (DAYS) | 543 534 505 | 452 551 656 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.420 P=0.087 P=0.491 | P=0.322N P=0.463N P=0.392N |
|INCIDENTAL TUMOR | P=0.295N P=0.317 P=0.380N | P=0.403N P=0.488N P=0.468N |
|LOGISTIC REGRESSION | P=0.324N P=0.137 P=0.598N | P=0.396N P=0.493N P=0.484N |
|COCHRAN-ARMITAGE | P=0.547 | P=0.421N |
|FISHER EXACT | P=0.127 P=0.598N | P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.0 20.0 | VEHICLE 20.0 40.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 16/50 (32%) 18/50 (36%) 20/50 (40%) | 6/50 (12%) 4/50 (8%) 7/50 (14%) |
|ADJUSTED (b) | 41.8% 45.8% 52.3% | 19.2% 12.4% 17.6% |
|TERMINAL (d) | 13/35 (37%) 8/27 (30%) 12/29 (41%) | 3/26 (12%) 3/29 (10%) 3/34 (9%) |
|FIRST INCIDENCE (DAYS) | 543 534 505 | 452 551 624 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.128 P=0.245 P=0.141 | P=0.525N P=0.330N P=0.559N |
|INCIDENTAL TUMOR | P=0.359 P=0.587N P=0.351 | P=0.477 P=0.366N P=0.540 |
|LOGISTIC REGRESSION | P=0.229 P=0.471 P=0.253 | P=0.497 P=0.358N P=0.558 |
|COCHRAN-ARMITAGE | P=0.233 | P=0.437 |
|FISHER EXACT | P=0.417 P=0.266 | P=0.370N P=0.500 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 16/50 (32%) 18/50 (36%) 20/50 (40%) | 6/50 (12%) 4/50 (8%) 7/50 (14%) |
|ADJUSTED (b) | 41.8% 45.8% 52.3% | 19.2% 12.4% 17.6% |
|TERMINAL (d) | 13/35 (37%) 8/27 (30%) 12/29 (41%) | 3/26 (12%) 3/29 (10%) 3/34 (9%) |
|FIRST INCIDENCE (DAYS) | 543 534 505 | 452 551 624 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.128 P=0.245 P=0.141 | P=0.525N P=0.330N P=0.559N |
|INCIDENTAL TUMOR | P=0.359 P=0.587N P=0.351 | P=0.477 P=0.366N P=0.540 |
|LOGISTIC REGRESSION | P=0.229 P=0.471 P=0.253 | P=0.497 P=0.358N P=0.558 |
|COCHRAN-ARMITAGE | P=0.233 | P=0.437 |
|FISHER EXACT | P=0.417 P=0.266 | P=0.370N P=0.500 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.0 20.0 | VEHICLE 20.0 40.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/50 (18%) 14/50 (28%) 9/50 (18%) | 1/50 (2%) 3/50 (6%) 5/50 (10%) |
|ADJUSTED (b) | 24.7% 44.1% 27.0% | 3.7% 9.4% 14.7% |
|TERMINAL (d) | 8/35 (23%) 10/27 (37%) 6/29 (21%) | 0/26 (0%) 2/29 (7%) 5/34 (15%) |
|FIRST INCIDENCE (DAYS) | 543 637 573 | 724 632 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.375 P=0.064 P=0.463 | P=0.127 P=0.339 P=0.173 |
|INCIDENTAL TUMOR | P=0.506 P=0.151 P=0.603N | P=0.094 P=0.301 P=0.155 |
|LOGISTIC REGRESSION | P=0.492 P=0.171 P=0.573 | P=0.106 P=0.313 P=0.160 |
|COCHRAN-ARMITAGE | P=0.549N | P=0.070 |
|FISHER EXACT | P=0.171 P=0.602N | P=0.309 P=0.102 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 2/50 (4%) | 2/50 (4%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 2.6% 6.8% 6.9% | 6.4% 0.0% 2.9% |
|TERMINAL (d) | 0/35 (0%) 1/27 (4%) 2/29 (7%) | 1/26 (4%) 0/29 (0%) 1/34 (3%) |
|FIRST INCIDENCE (DAYS) | 590 714 729 (T) | 602 --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.336 P=0.465 P=0.447 | P=0.301N P=0.231N P=0.419N |
|INCIDENTAL TUMOR | P=0.404 P=0.712 P=0.562 | P=0.363N P=0.228N P=0.516N |
|LOGISTIC REGRESSION | P=0.377 P=0.509 P=0.497 | P=0.335N P=0.234N P=0.469N |
|COCHRAN-ARMITAGE | P=0.390 | P=0.360N |
|FISHER EXACT | P=0.500 P=0.500 | P=0.247N P=0.500N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.0 20.0 | VEHICLE 20.0 40.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 15/50 (30%) 10/50 (20%) | 3/50 (6%) 3/50 (6%) 6/50 (12%) |
|ADJUSTED (b) | 26.6% 45.9% 30.1% | 9.8% 9.4% 17.6% |
|TERMINAL (d) | 8/35 (23%) 10/27 (37%) 7/29 (24%) | 1/26 (4%) 2/29 (7%) 6/34 (18%) |
|FIRST INCIDENCE (DAYS) | 543 637 573 | 602 632 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.368 P=0.074 P=0.452 | P=0.294 P=0.627N P=0.381 |
|INCIDENTAL TUMOR | P=0.527 P=0.224 P=0.564N | P=0.213 P=0.659N P=0.303 |
|LOGISTIC REGRESSION | P=0.498 P=0.194 P=0.576 | P=0.242 P=0.654N P=0.325 |
|COCHRAN-ARMITAGE | P=0.547N | P=0.178 |
|FISHER EXACT | P=0.178 P=0.598N | P=0.661N P=0.243 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 7.2% 0.0% 0.0% |
|TERMINAL (d) | 0/35 (0%) 0/27 (0%) 0/29 (0%) | 1/26 (4%) 0/29 (0%) 0/34 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 707 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.075N P=0.228N P=0.186N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.094N P=0.258N P=0.224N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.080N P=0.231N P=0.198N |
|COCHRAN-ARMITAGE | (e) | P=0.095N |
|FISHER EXACT | (e) (e) | P=0.247N P=0.247N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.0 20.0 | VEHICLE 20.0 40.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 2/46 (4%) 0/47 (0%) 0/49 (0%) |
|ADJUSTED (b) | | 8.0% 0.0% 0.0% |
|TERMINAL (d) | | 2/25 (8%) 0/27 (0%) 0/33 (0%) |
|FIRST INCIDENCE (DAYS) | | 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.072N P=0.221N P=0.179N |
|INCIDENTAL TUMOR | | P=0.072N P=0.221N P=0.179N |
|LOGISTIC REGRESSION | | P=0.072N P=0.221N P=0.179N |
|COCHRAN-ARMITAGE | | P=0.090N |
|FISHER EXACT | | P=0.242N P=0.232N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/40 (0%) 1/44 (2%) 1/40 (3%) | 11/45 (24%) 6/45 (13%) 6/44 (14%) |
|ADJUSTED (b) | 0.0% 4.0% 3.8% | 37.6% 22.2% 19.4% |
|TERMINAL (d) | 0/30 (0%) 1/25 (4%) 1/26 (4%) | 8/25 (32%) 6/27 (22%) 6/31 (19%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 729 (T) | 427 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.304 P=0.464 P=0.471 | P=0.041N* P=0.108N P=0.060N |
|INCIDENTAL TUMOR | P=0.304 P=0.464 P=0.471 | P=0.050N P=0.121N P=0.077N |
|LOGISTIC REGRESSION | P=0.304 P=0.464 P=0.471 | P=0.072N P=0.153N P=0.111N |
|COCHRAN-ARMITAGE | P=0.329 | P=0.112N |
|FISHER EXACT | P=0.524 P=0.500 | P=0.141N P=0.152N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.0 20.0 | VEHICLE 20.0 40.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/40 (0%) 1/44 (2%) 1/40 (3%) | 12/45 (27%) 6/45 (13%) 6/44 (14%) |
|ADJUSTED (b) | 0.0% 4.0% 3.8% | 41.2% 22.2% 19.4% |
|TERMINAL (d) | 0/30 (0%) 1/25 (4%) 1/26 (4%) | 9/25 (36%) 6/27 (22%) 6/31 (19%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 729 (T) | 427 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.304 P=0.464 P=0.471 | P=0.022N* P=0.067N P=0.034N* |
|INCIDENTAL TUMOR | P=0.304 P=0.464 P=0.471 | P=0.027N* P=0.076N P=0.045N* |
|LOGISTIC REGRESSION | P=0.304 P=0.464 P=0.471 | P=0.042N* P=0.102N P=0.069N |
|COCHRAN-ARMITAGE | P=0.329 | P=0.071N |
|FISHER EXACT | P=0.524 P=0.500 | P=0.093N P=0.102N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/40 (0%) 0/44 (0%) 0/40 (0%) | 2/45 (4%) 1/45 (2%) 0/44 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 8.0% 3.7% 0.0% |
|TERMINAL (d) | 0/30 (0%) 0/25 (0%) 0/26 (0%) | 2/25 (8%) 1/27 (4%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 729 (T) 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.110N P=0.473N P=0.192N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.110N P=0.473N P=0.192N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.110N P=0.473N P=0.192N |
|COCHRAN-ARMITAGE | (e) | P=0.145N |
|FISHER EXACT | (e) (e) | P=0.500N P=0.253N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.0 20.0 | VEHICLE 20.0 40.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 3.7% 5.5% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/35 (0%) 1/27 (4%) 0/29 (0%) | 0/26 (0%) 0/29 (0%) 0/34 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 579 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.125 P=0.448 P=0.220 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.228 P=0.448 P=0.464 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.142 P=0.448 P=0.234 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.142 | (e) |
|FISHER EXACT | P=0.500 P=0.247 | (e) (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 0/50 (0%) 3/50 (6%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 13.8% 0.0% 10.3% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 4/35 (11%) 0/27 (0%) 3/29 (10%) | 0/26 (0%) 0/29 (0%) 0/34 (0%) |
|FIRST INCIDENCE (DAYS) | 690 --- 729 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.336N P=0.058N P=0.465N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.319N P=0.023N* P=0.449N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.308N P=0.036N* P=0.434N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.252N | (e) |
|FISHER EXACT | P=0.028N* P=0.357N | (e) (e) |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.0 20.0 | VEHICLE 20.0 40.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 8/50 (16%) 7/50 (14%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 16.6% 23.9% 20.9% | 0.0% 0.0% 2.3% |
|TERMINAL (d) | 5/35 (14%) 4/27 (15%) 5/29 (17%) | 0/26 (0%) 0/29 (0%) 0/34 (0%) |
|FIRST INCIDENCE (DAYS) | 690 616 422 | --- --- 624 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.326 P=0.265 P=0.386 | P=0.300 (e) P=0.540 |
|INCIDENTAL TUMOR | P=0.467 P=0.521 P=0.442 | P=0.175 (e) P=0.362 |
|LOGISTIC REGRESSION | P=0.429 P=0.408 P=0.487 | P=0.266 (e) P=0.495 |
|COCHRAN-ARMITAGE | P=0.443 | P=0.269 |
|FISHER EXACT | P=0.387 P=0.500 | (e) P=0.500 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 2.5% 0.0% | 0.0% 0.0% 5.0% |
|TERMINAL (d) | 0/35 (0%) 0/27 (0%) 0/29 (0%) | 0/26 (0%) 0/29 (0%) 1/34 (3%) |
|FIRST INCIDENCE (DAYS) | --- 624 --- | --- --- 520 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.722 P=0.510 (e) | P=0.118 (e) P=0.282 |
|INCIDENTAL TUMOR | P=0.613N P=0.638 (e) | P=0.139 (e) P=0.316 |
|LOGISTIC REGRESSION | P=0.726 P=0.479 (e) | P=0.092 (e) P=0.229 |
|COCHRAN-ARMITAGE | P=0.731 | P=0.095 |
|FISHER EXACT | P=0.500 (e) | (e) P=0.247 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.0 20.0 | VEHICLE 20.0 40.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 9/50 (18%) 10/50 (20%) 10/50 (20%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 24.9% 28.7% 29.0% | 0.0% 0.0% 2.3% |
|TERMINAL (d) | 8/35 (23%) 5/27 (19%) 7/29 (24%) | 0/26 (0%) 0/29 (0%) 0/34 (0%) |
|FIRST INCIDENCE (DAYS) | 690 511 422 | --- --- 624 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.313 P=0.336 P=0.358 | P=0.300 (e) P=0.540 |
|INCIDENTAL TUMOR | P=0.431 P=0.554 P=0.402 | P=0.175 (e) P=0.362 |
|LOGISTIC REGRESSION | P=0.442 P=0.537 P=0.486 | P=0.266 (e) P=0.495 |
|COCHRAN-ARMITAGE | P=0.450 | P=0.269 |
|FISHER EXACT | P=0.500 P=0.500 | (e) P=0.500 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 10/50 (20%) 8/50 (16%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 19.4% 28.7% 22.5% | 0.0% 0.0% 2.3% |
|TERMINAL (d) | 6/35 (17%) 5/27 (19%) 5/29 (17%) | 0/26 (0%) 0/29 (0%) 0/34 (0%) |
|FIRST INCIDENCE (DAYS) | 690 511 422 | --- --- 624 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.328 P=0.187 P=0.385 | P=0.300 (e) P=0.540 |
|INCIDENTAL TUMOR | P=0.455 P=0.368 P=0.435 | P=0.175 (e) P=0.362 |
|LOGISTIC REGRESSION | P=0.445 P=0.328 P=0.496 | P=0.266 (e) P=0.495 |
|COCHRAN-ARMITAGE | P=0.447 | P=0.269 |
|FISHER EXACT | P=0.298 P=0.500 | (e) P=0.500 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.0 20.0 | VEHICLE 20.0 40.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.9% 5.6% 2.1% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/35 (3%) 1/27 (4%) 0/29 (0%) | 0/26 (0%) 0/29 (0%) 0/34 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 511 466 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.592 P=0.452 P=0.745 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.589 P=0.407 P=0.740 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.610 P=0.494 P=0.758 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.622N | (e) |
|FISHER EXACT | P=0.500 P=0.753N | (e) (e) |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 0.0% 5.9% |
|TERMINAL (d) | 0/35 (0%) 0/27 (0%) 0/29 (0%) | 0/26 (0%) 0/29 (0%) 2/34 (6%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.125 (e) P=0.299 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.125 (e) P=0.299 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.125 (e) P=0.299 |
|COCHRAN-ARMITAGE | (e) | P=0.095 |
|FISHER EXACT | (e) (e) | (e) P=0.247 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 02 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.0 20.0 | VEHICLE 20.0 40.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 5/50 (10%) | 5/50 (10%) 6/50 (12%) 19/50 (38%) |
|ADJUSTED (b) | 2.9% 3.2% 17.2% | 17.4% 18.1% 47.5% |
|TERMINAL (d) | 1/35 (3%) 0/27 (0%) 5/29 (17%) | 3/26 (12%) 4/29 (14%) 14/34 (41%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 714 729 (T) | 669 442 520 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.033 * P=0.718 P=0.064 | P=0.004 ** P=0.556 P=0.011 * |
|INCIDENTAL TUMOR | P=0.029 * P=0.645N P=0.064 | P=0.001 ** P=0.494 P=0.003 ** |
|LOGISTIC REGRESSION | P=0.032 * P=0.753 P=0.064 | P<0.001 ** P=0.515 P=0.003 ** |
|COCHRAN-ARMITAGE | P=0.049 * | P<0.001 ** |
|FISHER EXACT | P=0.753N P=0.102 | P=0.500 P<0.001 ** |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 5/50 (10%) | 5/50 (10%) 6/50 (12%) 18/50 (36%) |
|ADJUSTED (b) | 2.9% 3.2% 17.2% | 17.4% 18.1% 44.9% |
|TERMINAL (d) | 1/35 (3%) 0/27 (0%) 5/29 (17%) | 3/26 (12%) 4/29 (14%) 13/34 (38%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 714 729 (T) | 669 442 520 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.033 * P=0.718 P=0.064 | P=0.006 ** P=0.556 P=0.016 * |
|INCIDENTAL TUMOR | P=0.029 * P=0.645N P=0.064 | P=0.002 ** P=0.494 P=0.005 ** |
|LOGISTIC REGRESSION | P=0.032 * P=0.753 P=0.064 | P=0.002 ** P=0.515 P=0.004 ** |
|COCHRAN-ARMITAGE | P=0.049 * | P<0.001 ** |
|FISHER EXACT | P=0.753N P=0.102 | P=0.500 P=0.002 ** |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 02 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.0 20.0 | VEHICLE 20.0 40.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/45 (0%) 3/50 (6%) 0/49 (0%) | 3/49 (6%) 4/48 (8%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 9.6% 0.0% | 8.7% 14.3% 8.2% |
|TERMINAL (d) | 0/31 (0%) 2/27 (7%) 0/29 (0%) | 1/26 (4%) 4/28 (14%) 2/34 (6%) |
|FIRST INCIDENCE (DAYS) | --- 616 --- | 582 729 (T) 656 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.621 P=0.112 (e) | P=0.454N P=0.523 P=0.562N |
|INCIDENTAL TUMOR | P=0.582N P=0.142 (e) | P=0.550N P=0.529 P=0.612 |
|LOGISTIC REGRESSION | P=0.625N P=0.146 (e) | P=0.520N P=0.498 P=0.635N |
|COCHRAN-ARMITAGE | P=0.618N | P=0.568N |
|FISHER EXACT | P=0.142 (e) | P=0.488 P=0.651N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/45 (0%) 3/50 (6%) 0/49 (0%) | 4/49 (8%) 4/48 (8%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 9.6% 0.0% | 12.3% 14.3% 8.2% |
|TERMINAL (d) | 0/31 (0%) 2/27 (7%) 0/29 (0%) | 2/26 (8%) 4/28 (14%) 2/34 (6%) |
|FIRST INCIDENCE (DAYS) | --- 616 --- | 582 729 (T) 656 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.621 P=0.112 (e) | P=0.301N P=0.618N P=0.385N |
|INCIDENTAL TUMOR | P=0.582N P=0.142 (e) | P=0.382N P=0.613N P=0.532N |
|LOGISTIC REGRESSION | P=0.625N P=0.146 (e) | P=0.360N P=0.643 P=0.457N |
|COCHRAN-ARMITAGE | P=0.618N | P=0.413N |
|FISHER EXACT | P=0.142 (e) | P=0.631 P=0.489N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 02 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.0 20.0 | VEHICLE 20.0 40.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | | 6.7% 0.0% 0.0% |
|TERMINAL (d) | | 0/26 (0%) 0/29 (0%) 0/34 (0%) |
|FIRST INCIDENCE (DAYS) | | 693 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.079N P=0.236N P=0.194N |
|INCIDENTAL TUMOR | | P=0.114N P=0.298N P=0.262N |
|LOGISTIC REGRESSION | | P=0.084N P=0.232N P=0.210N |
|COCHRAN-ARMITAGE | | P=0.095N |
|FISHER EXACT | | P=0.247N P=0.247N |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 3/50 (6%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | | 10.3% 0.0% 2.9% |
|TERMINAL (d) | | 1/26 (4%) 0/29 (0%) 1/34 (3%) |
|FIRST INCIDENCE (DAYS) | | 693 --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.132N P=0.116N P=0.227N |
|INCIDENTAL TUMOR | | P=0.166N P=0.145N P=0.280N |
|LOGISTIC REGRESSION | | P=0.142N P=0.115N P=0.247N |
|COCHRAN-ARMITAGE | | P=0.176N |
|FISHER EXACT | | P=0.121N P=0.309N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 02 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.0 20.0 | VEHICLE 20.0 40.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 3/50 (6%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 5.7% 7.3% 0.0% | 3.8% 0.0% 5.0% |
|TERMINAL (d) | 2/35 (6%) 0/27 (0%) 0/29 (0%) | 1/26 (4%) 0/29 (0%) 1/34 (3%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 514 --- | 729 (T) --- 520 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.243N P=0.458 P=0.280N | P=0.421 P=0.478N P=0.575 |
|INCIDENTAL TUMOR | P=0.168N P=0.613 P=0.280N | P=0.450 P=0.478N P=0.608 |
|LOGISTIC REGRESSION | P=0.202N P=0.490 P=0.280N | P=0.373 P=0.478N P=0.514 |
|COCHRAN-ARMITAGE | P=0.202N | P=0.360 |
|FISHER EXACT | P=0.500 P=0.247N | P=0.500N P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 3/50 (6%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 8.6% 7.3% 0.0% | 3.8% 0.0% 5.0% |
|TERMINAL (d) | 3/35 (9%) 0/27 (0%) 0/29 (0%) | 1/26 (4%) 0/29 (0%) 1/34 (3%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 514 --- | 729 (T) --- 520 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.135N P=0.604 P=0.156N | P=0.421 P=0.478N P=0.575 |
|INCIDENTAL TUMOR | P=0.087N P=0.591N P=0.156N | P=0.450 P=0.478N P=0.608 |
|LOGISTIC REGRESSION | P=0.100N P=0.662N P=0.156N | P=0.373 P=0.478N P=0.514 |
|COCHRAN-ARMITAGE | P=0.101N | P=0.360 |
|FISHER EXACT | P=0.661N P=0.121N | P=0.500N P=0.500 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 02 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.0 20.0 | VEHICLE 20.0 40.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 2/50 (4%) 4/50 (8%) | 16/50 (32%) 11/50 (22%) 9/50 (18%) |
|ADJUSTED (b) | 17.8% 7.4% 10.3% | 42.6% 30.8% 24.6% |
|TERMINAL (d) | 4/35 (11%) 2/27 (7%) 0/29 (0%) | 6/26 (23%) 6/29 (21%) 7/34 (21%) |
|FIRST INCIDENCE (DAYS) | 527 729 (T) 578 | 452 568 654 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.250N P=0.127N P=0.333N | P=0.024N* P=0.171N P=0.031N* |
|INCIDENTAL TUMOR | P=0.096N P=0.093N P=0.098N | P=0.063N P=0.188N P=0.082N |
|LOGISTIC REGRESSION | P=0.188N P=0.074N P=0.262N | P=0.037N* P=0.168N P=0.050N* |
|COCHRAN-ARMITAGE | P=0.187N | P=0.064N |
|FISHER EXACT | P=0.080N P=0.262N | P=0.184N P=0.083N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 2/50 (4%) 4/50 (8%) | 16/50 (32%) 11/50 (22%) 9/50 (18%) |
|ADJUSTED (b) | 17.8% 7.4% 10.3% | 42.6% 30.8% 24.6% |
|TERMINAL (d) | 4/35 (11%) 2/27 (7%) 0/29 (0%) | 6/26 (23%) 6/29 (21%) 7/34 (21%) |
|FIRST INCIDENCE (DAYS) | 527 729 (T) 578 | 452 568 654 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.250N P=0.127N P=0.333N | P=0.024N* P=0.171N P=0.031N* |
|INCIDENTAL TUMOR | P=0.096N P=0.093N P=0.098N | P=0.063N P=0.188N P=0.082N |
|LOGISTIC REGRESSION | P=0.188N P=0.074N P=0.262N | P=0.037N* P=0.168N P=0.050N* |
|COCHRAN-ARMITAGE | P=0.187N | P=0.064N |
|FISHER EXACT | P=0.080N P=0.262N | P=0.184N P=0.083N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 02 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.0 20.0 | VEHICLE 20.0 40.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 24/50 (48%) 26/50 (52%) 28/50 (56%) | 26/50 (52%) 17/50 (34%) 32/50 (64%) |
|ADJUSTED (b) | 62.9% 67.5% 74.8% | 71.6% 52.2% 72.3% |
|TERMINAL (d) | 21/35 (60%) 15/27 (56%) 20/29 (69%) | 16/26 (62%) 14/29 (48%) 22/34 (65%) |
|FIRST INCIDENCE (DAYS) | 541 559 573 | 427 442 520 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.078 P=0.142 P=0.084 | P=0.530N P=0.031N* P=0.507N |
|INCIDENTAL TUMOR | P=0.227 P=0.534 P=0.238 | P=0.309 P=0.033N* P=0.308 |
|LOGISTIC REGRESSION | P=0.186 P=0.504 P=0.215 | P=0.283 P=0.034N* P=0.328 |
|COCHRAN-ARMITAGE | P=0.242 | P=0.136 |
|FISHER EXACT | P=0.421 P=0.274 | P=0.053N P=0.156 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 24/50 (48%) 31/50 (62%) 23/50 (46%) | 24/50 (48%) 15/50 (30%) 18/50 (36%) |
|ADJUSTED (b) | 55.7% 68.8% 53.0% | 60.6% 39.9% 41.4% |
|TERMINAL (d) | 16/35 (46%) 14/27 (52%) 10/29 (34%) | 11/26 (42%) 8/29 (28%) 9/34 (26%) |
|FIRST INCIDENCE (DAYS) | 527 511 422 | 452 551 520 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.385 P=0.067 P=0.441 | P=0.045N* P=0.056N P=0.051N |
|INCIDENTAL TUMOR | P=0.185N P=0.363 P=0.237N | P=0.132N P=0.042N* P=0.151N |
|LOGISTIC REGRESSION | P=0.189N P=0.137 P=0.497N | P=0.097N P=0.028N* P=0.121N |
|COCHRAN-ARMITAGE | P=0.460N | P=0.129N |
|FISHER EXACT | P=0.114 P=0.500N | P=0.050N P=0.156N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 02 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.0 20.0 | VEHICLE 20.0 40.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 37/50 (74%) 41/50 (82%) 37/50 (74%) | 37/50 (74%) 26/50 (52%) 37/50 (74%) |
|ADJUSTED (b) | 84.1% 88.8% 85.6% | 90.1% 67.3% 80.3% |
|TERMINAL (d) | 28/35 (80%) 22/27 (81%) 23/29 (79%) | 22/26 (85%) 17/29 (59%) 25/34 (74%) |
|FIRST INCIDENCE (DAYS) | 527 511 422 | 427 442 520 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.199 P=0.066 P=0.229 | P=0.112N P=0.020N* P=0.103N |
|INCIDENTAL TUMOR | P=0.372N P=0.503 P=0.456N | P=0.316N P=0.007N** P=0.313N |
|LOGISTIC REGRESSION | P=0.512N P=0.417 P=0.566N | P=0.270N P=0.007N** P=0.265N |
|COCHRAN-ARMITAGE | P=0.547 | P=0.542 |
|FISHER EXACT | P=0.235 P=0.590N | P=0.019N* P=0.590N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
--multipart-boundary
Content-type: text/plain
Range: bytes 139039-139039/139039
--multipart-boundary--