TDMS Study 05049-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/07/94
EXP: 05049 DICHLORVOS TIME: 05:51:43
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 00113B
CONT: N01-ES-28024 CAS: 62-73-7
PATHOLOGIST: J. HEATH S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/07/94
EXP: 05049 DICHLORVOS TIME: 05:51:43
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 00113B
CONT: N01-ES-28024 CAS: 62-73-7
PATHOLOGIST: J. HEATH S. EUSTIS
DICHLORVOS
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 1 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 70 105 212 402 527 541 543 550 579 585 |
| 590 634 690 694 |
| CENSORED DEATHS |
| 8 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10.0 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 511 514 534 551 556 559 578 589 616 616 |
| 624 637 638 645 668 669 672 694 694 714 |
| 724 727 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 20.0 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 2 210 422 466 505 533 565 573 578 578 |
| 578 578 578 579 619 634 635 637 640 668 |
| 727 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DICHLORVOS
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 98.0 95.9 93.9 93.9 91.8 91.8 85.7 77.6 75.5 71.4 |
|CONTROL | |
| | |
|10.0 | 100.0 100.0 100.0 100.0 100.0 100.0 94.0 84.0 72.0 54.0 |
|MG/KG | |
| | |
|20.0 | 98.0 98.0 96.0 96.0 94.0 92.0 88.0 72.0 62.0 58.0 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 10.0 20.0 |
| CONTROL MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 71.4% 54.0% 58.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.218 P=0.206 P=0.266 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 480.1 628.6 538.3 |
|NATURAL DEATHS (C) | (54.9) (14.5) (35.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 644.9 682.8 648.9 |
|(STANDARD ERROR) | (25.4) ( 9.7) (19.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DICHLORVOS
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 6 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 427 452 568 579 582 601 602 611 625 633 |
| 646 668 669 693 706 707 709 724 |
| CENSORED DEATHS |
| 7 8 9 9 9 10 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 20.0 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 5 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 442 511 551 568 575 576 589 590 632 638 |
| 656 667 667 669 699 703 |
| CENSORED DEATHS |
| 1 2 4 6 7 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 40.0 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 2 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 368 520 534 623 624 634 640 654 656 672 |
| 676 708 709 709 |
| CENSORED DEATHS |
| 7 8 |
| |
==================================================================================
DICHLORVOS
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 100.0 95.5 95.5 84.1 75.0 59.1 |
|CONTROL | |
| | |
|20.0 | 100.0 100.0 100.0 100.0 100.0 97.8 95.6 82.2 75.6 64.4 |
|MG/KG | |
| | |
|40.0 | 100.0 100.0 100.0 100.0 97.9 97.9 93.8 93.8 81.3 70.8 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 20.0 40.0 |
| CONTROL MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 59.1% 64.4% 70.8% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.271N P=0.840N P=0.296N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 622.3 608.3 623.4 |
|NATURAL DEATHS (C) | (19.5) (17.8) (24.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 604.2 617.9 670.6 |
|(STANDARD ERROR) | (32.9) (30.8) (21.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DICHLORVOS
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
10.0 MG/KG = 2
20.0 MG/KG = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 13 1 2
|
| 3 1 1 3 22
| 1 31 3 2 2
95 +
| 1 1 3 3 2 2
| 3 3 22
| 1 1
90 + 3 131
|
| 3 23 2
| 11 332 2
P 85 +
E | 1 31 2 2
R |
C | 11
E 80 + 1 1 2 2
N |
T | 1 21
| 22
S 75 + 1 1
U | 22 11
R | 3 3 2 2
V | 1 1
I 70 + 3 3
V |
A |
L | 2 2
65 +
| 33
| 3 3 2 2
|
60 + 3 2 2
|
| 3 3
|
55 +
| 2 2
|
|
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.
DICHLORVOS
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
20.0 MG/KG = 2
40.0 MG/KG = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 1 2
|
| 3 1 2 1 2 3
| 3 3
95 + 1 2 2 1
| 3 2 11 3
|
| 211 33
90 + 33
| 1 1
P | 33
E | 2 2
R 85 + 3 3
C | 1 1
E | 2 2
N | 1 1 3 3
T 80 + 112
| 33
S | 1212 3 3
U |
R 75 + 12 1
V |
I |
V | 3 3
A 70 + 1 1
L | 2 121
|
| 22
65 + 2 2
| 11
|
| 1 1
60 +
| 1 1
|
|
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 6 obs hidden.
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