TDMS Study 05049-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
DICHLORVOS
NTP Experiment-Test: 05049-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/07/94
Route: GAVAGE Time: 02:52:19
Facility: Southern Research Institute
Chemical CAS #: 62-73-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05049-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 02:52:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 4.0 8.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Dead 4 3 5
Accident 1
Moribund 14 21 19
Survivors
Terminal Sacrifice 31 26 26
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large (50) (49) (50)
Rectum, Leiomyosarcoma 1 (2%)
Intestine Small (50) (49) (50)
Jejunum, Leiomyoma 1 (2%)
Liver (50) (50) (50)
Hepatocellular Carcinoma 1 (2%)
Neoplastic Nodule 1 (2%)
Mesentery (10) (12) (7)
Pancreas (50) (47) (50)
Adenoma 1 (2%) 1 (2%) 4 (8%)
Pharynx (1) (2)
Squamous Cell Carcinoma 1 (50%)
Salivary Glands (49) (50) (49)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Stomach (50) (49) (50)
Forestomach, Squamous Cell Papilloma 1 (2%)
Tongue (3) (1) (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (50) (50)
Pheochromocytoma Benign 1 (2%)
Cortex, Adenoma 1 (2%) 4 (8%)
Medulla, Pheochromocytoma Malignant 2 (4%)
Medulla, Pheochromocytoma Benign 4 (8%) 1 (2%) 2 (4%)
Page 2
NTP Experiment-Test: 05049-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 02:52:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 4.0 8.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Medulla, Pheochromocytoma Benign, Multiple 2 (4%)
Islets, Pancreatic (50) (48) (50)
Adenoma 1 (2%) 2 (4%) 1 (2%)
Parathyroid Gland (49) (47) (45)
Adenoma 1 (2%)
Pituitary Gland (50) (49) (50)
Pars Distalis, Adenoma 27 (54%) 19 (39%) 19 (38%)
Pars Distalis, Carcinoma 1 (2%) 2 (4%) 4 (8%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%)
Pars Intermedia, Carcinoma 1 (2%)
Thyroid Gland (50) (49) (50)
C-Cell, Adenoma 4 (8%) 7 (14%) 5 (10%)
C-Cell, Adenoma, Multiple 1 (2%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (44) (43) (41)
Adenoma 3 (7%) 1 (2%) 3 (7%)
Carcinoma 1 (2%)
Ovary (50) (50) (50)
Granulosa Cell Tumor 2 (4%)
Leiomyosarcoma 1 (2%)
Uterus (50) (50) (50)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Leiomyoma 1 (2%)
Leiomyosarcoma 1 (2%)
Polyp Stromal 15 (30%) 14 (28%) 13 (26%)
Sarcoma Stromal 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (2) (2) (3)
Bone Marrow (50) (49) (50)
Lymph Node (50) (50) (50)
Spleen (50) (50) (50)
Thymus (39) (39) (39)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05049-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 02:52:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 4.0 8.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (49)
Adenoma 1 (2%)
Carcinoma 2 (4%) 2 (4%)
Fibroadenoma 9 (18%) 13 (26%) 13 (27%)
Fibroadenoma, Multiple 6 (12%) 3 (6%)
Skin (50) (48) (48)
Basal Cell Carcinoma 1 (2%)
Keratoacanthoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%) 1 (2%)
Sebaceous Gland, Carcinoma 2 (4%)
Subcutaneous Tissue, Fibroma 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1)
Squamous Cell Carcinoma, Metastatic, Lung 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Oligodendroglioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Nose (50) (49) (47)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Adenoma 1 (2%)
Urinary Bladder (50) (49) (50)
Page 4
NTP Experiment-Test: 05049-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 02:52:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 4.0 8.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont
Papilloma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 17 (34%) 21 (42%) 23 (46%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05049-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 02:52:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 4.0 8.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 47 46 46
Total Primary Neoplasms 97 108 111
Total Animals with Benign Neoplasms 40 40 39
Total Benign Neoplasms 70 75 75
Total Animals with Malignant Neoplasms 23 32 30
Total Malignant Neoplasms 25 33 36
Total Animals with Metastatic Neoplasms 1 2
Total Metastatic Neoplasm 1 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 2
Total Uncertain Neoplasms 2
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05049-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 02:52:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 4.0 8.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund 14 17 18
Dead 4 3 4
Accident 1 5 4
Survivors
Terminal Sacrifice 31 25 24
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large (50) (49) (50)
Cecum, Lipoma 1 (2%)
Colon, Polyp Adenomatous 1 (2%)
Intestine Small (50) (50) (50)
Sarcoma, Metastatic, Mesentery 1 (2%)
Liver (50) (50) (50)
Hepatocellular Carcinoma 1 (2%) 1 (2%) 1 (2%)
Neoplastic Nodule 2 (4%) 1 (2%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Mesentery (9) (7) (8)
Sarcoma 1 (11%)
Pancreas (50) (49) (50)
Adenoma 14 (28%) 18 (37%) 17 (34%)
Adenoma, Multiple 2 (4%) 7 (14%) 13 (26%)
Pharynx (1) (2) (1)
Palate, Fibrosarcoma 1 (100%)
Salivary Glands (48) (48) (49)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Stomach (50) (49) (50)
Forestomach, Fibrosarcoma 1 (2%)
Forestomach, Squamous Cell Papilloma 2 (4%) 1 (2%)
Glandular, Adenoma 1 (2%)
Tongue (1) (2)
Squamous Cell Papilloma 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (49)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05049-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 02:52:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 4.0 8.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (50) (50)
Cortex, Adenoma 1 (2%) 1 (2%)
Medulla, Pheochromocytoma Malignant 2 (4%) 5 (10%) 4 (8%)
Medulla, Pheochromocytoma Malignant, Multiple 1 (2%)
Medulla, Pheochromocytoma Benign 13 (26%) 12 (24%) 12 (24%)
Medulla, Pheochromocytoma Benign, Multiple 8 (16%) 4 (8%) 2 (4%)
Islets, Pancreatic (50) (48) (50)
Adenoma 6 (12%) 5 (10%) 3 (6%)
Adenoma, Multiple 1 (2%) 2 (4%)
Parathyroid Gland (45) (46) (47)
Adenoma 1 (2%) 1 (2%)
Pituitary Gland (50) (48) (49)
Pars Distalis, Adenoma 9 (18%) 11 (23%) 7 (14%)
Pars Distalis, Carcinoma 1 (2%) 2 (4%)
Pars Intermedia, Adenoma 2 (4%)
Thyroid Gland (49) (49) (49)
C-Cell, Adenoma 6 (12%) 9 (18%) 7 (14%)
C-Cell, Adenoma, Multiple 1 (2%)
C-Cell, Carcinoma, Multiple 1 (2%)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (48) (46) (45)
Adenoma 2 (4%) 4 (9%) 3 (7%)
Carcinoma 1 (2%) 3 (7%)
Prostate (50) (50) (49)
Adenoma 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Seminal Vesicle (3) (4) (2)
Testes (50) (50) (50)
Interstitial Cell, Adenoma 29 (58%) 18 (36%) 19 (38%)
Interstitial Cell, Adenoma, Multiple 16 (32%) 28 (56%) 27 (54%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05049-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 02:52:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 4.0 8.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Lymph Node (50) (50) (50)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Spleen (49) (50) (50)
Fibrosarcoma 1 (2%)
Thymus (34) (29) (34)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (46) (44) (46)
Fibroadenoma 6 (13%) 1 (2%) 2 (4%)
Skin (49) (49) (49)
Basal Cell Adenoma 1 (2%)
Basal Cell Carcinoma 1 (2%) 2 (4%)
Carcinosarcoma 1 (2%)
Keratoacanthoma 3 (6%) 4 (8%) 1 (2%)
Squamous Cell Papilloma 3 (6%) 3 (6%) 2 (4%)
Trichoepithelioma 1 (2%)
Subcutaneous Tissue, Fibroma 7 (14%) 6 (12%) 4 (8%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 2 (4%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (48)
Astrocytoma Malignant 1 (2%) 1 (2%)
Granular Cell Tumor Benign 1 (2%)
Oligodendroglioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49)
Alveolar/Bronchiolar Adenoma 3 (6%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Neoplasm NOS, Metastatic 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Page 9
NTP Experiment-Test: 05049-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 02:52:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 4.0 8.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Adrenal Gland 1 (2%)
Nose (49) (49) (47)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (2) (28)
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Hamartoma 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (50) (50) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 11 (22%) 20 (40%) 21 (42%)
Lymphoma Malignant Histiocytic 1 (2%)
Lymphoma Malignant Lymphocytic 1 (2%)
Mesothelioma Malignant 3 (6%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05049-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DICHLORVOS Date: 09/07/94
Route: GAVAGE Time: 02:52:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 4.0 8.0
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 49 50
Total Primary Neoplasms 163 174 173
Total Animals with Benign Neoplasms 49 49 49
Total Benign Neoplasms 135 140 130
Total Animals with Malignant Neoplasms 25 29 32
Total Malignant Neoplasms 28 34 43
Total Animals with Metastatic Neoplasms 2 1 1
Total Metastatic Neoplasm 3 1 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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