TDMS Study 05049-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst DICHLORVOS DATE: 09/07/94
EXPERIMENT: 05049 TEST: 01 TIME: 03:04:20
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-28024 ROUTE: GAVAGE NTP C#: 00113B
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 62-73-7
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst DICHLORVOS DATE: 09/07/94
EXPERIMENT: 05049 TEST: 01 TIME: 03:04:20
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-28024 ROUTE: GAVAGE NTP C#: 00113B
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 62-73-7
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst DICHLORVOS DATE: 09/07/94
EXPERIMENT: 05049 TEST: 01 TIME: 03:04:20
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-28024 ROUTE: GAVAGE NTP C#: 00113B
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 62-73-7
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF DICHLORVOS
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Lung Alveolar/Bronchiolar Adenoma
Pancreas Adenoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
Malignant Tumors
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma or Adenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Skin: Subcutaneous Tissue Neurofibrosarcoma, Fibrosarcoma, Sarcoma,
Neurofibroma, or Fibroma
All Organs Malignant Tumors
====================================================================================================
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 4.0 8.0 | VEHICLE 4.0 8.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 0/50 (0%) | 1/50 (2%) 4/50 (8%) 0/50 (0%) |
|ADJUSTED (b) | 3.0% 4.0% 0.0% | 3.2% 12.5% 0.0% |
|TERMINAL (d) | 0/31 (0%) 1/25 (4%) 0/24 (0%) | 1/31 (3%) 2/26 (8%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 727 729 (T) --- | 729 (T) 656 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.411N P=0.705 P=0.555N | P=0.491N P=0.150 P=0.535N |
|INCIDENTAL TUMOR | P=0.351N P=0.756 P=0.452N | P=0.490N P=0.167 P=0.535N |
|LOGISTIC REGRESSION | P=0.409N P=0.696 P=0.546N | P=0.456N P=0.163 P=0.535N |
|COCHRAN-ARMITAGE | P=0.347N | P=0.426N |
|FISHER EXACT | P=0.753N P=0.500N | P=0.181 P=0.500N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 21/50 (42%) 16/50 (32%) 14/50 (28%) | 4/50 (8%) 1/50 (2%) 4/50 (8%) |
|ADJUSTED (b) | 57.6% 48.2% 43.8% | 10.8% 3.8% 14.7% |
|TERMINAL (d) | 16/31 (52%) 9/25 (36%) 8/24 (33%) | 2/31 (6%) 1/26 (4%) 3/26 (12%) |
|FIRST INCIDENCE (DAYS) | 595 561 564 | 602 729 (T) 727 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.283N P=0.472N P=0.321N | P=0.522 P=0.225N P=0.550 |
|INCIDENTAL TUMOR | P=0.129N P=0.322N P=0.166N | P=0.569 P=0.205N P=0.603 |
|LOGISTIC REGRESSION | P=0.121N P=0.332N P=0.145N | P=0.563 P=0.187N P=0.600 |
|COCHRAN-ARMITAGE | P=0.084N | P=0.569N |
|FISHER EXACT | P=0.204N P=0.104N | P=0.181N P=0.643N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 4.0 8.0 | VEHICLE 4.0 8.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 6/50 (12%) 4/50 (8%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 5.2% 22.9% 14.0% | 0.0% 0.0% 7.7% |
|TERMINAL (d) | 0/31 (0%) 5/25 (20%) 2/24 (8%) | 0/31 (0%) 0/26 (0%) 2/26 (8%) |
|FIRST INCIDENCE (DAYS) | 657 695 692 | --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.187 P=0.076 P=0.260 | P=0.091 (e) P=0.200 |
|INCIDENTAL TUMOR | P=0.251 P=0.112 P=0.369 | P=0.091 (e) P=0.200 |
|LOGISTIC REGRESSION | P=0.231 P=0.090 P=0.317 | P=0.091 (e) P=0.200 |
|COCHRAN-ARMITAGE | P=0.279 | P=0.106 |
|FISHER EXACT | P=0.134 P=0.339 | (e) P=0.247 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 22/50 (44%) 21/50 (42%) 18/50 (36%) | 4/50 (8%) 1/50 (2%) 6/50 (12%) |
|ADJUSTED (b) | 58.8% 62.6% 53.8% | 10.8% 3.8% 22.1% |
|TERMINAL (d) | 16/31 (52%) 13/25 (52%) 10/24 (42%) | 2/31 (6%) 1/26 (4%) 5/26 (19%) |
|FIRST INCIDENCE (DAYS) | 595 561 564 | 602 729 (T) 727 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.505 P=0.325 P=0.558 | P=0.231 P=0.225N P=0.273 |
|INCIDENTAL TUMOR | P=0.340N P=0.491 P=0.367N | P=0.263 P=0.205N P=0.313 |
|LOGISTIC REGRESSION | P=0.336N P=0.461 P=0.356N | P=0.257 P=0.187N P=0.309 |
|COCHRAN-ARMITAGE | P=0.243N | P=0.307 |
|FISHER EXACT | P=0.500N P=0.270N | P=0.181N P=0.370 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 4.0 8.0 | VEHICLE 4.0 8.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Brain |
| Oligodendroglioma, Glioma, or Astrocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 1/48 (2%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.4% 0.0% 4.2% | 3.2% 0.0% 0.0% |
|TERMINAL (d) | 1/31 (3%) 0/25 (0%) 1/24 (4%) | 1/31 (3%) 0/26 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 606 --- 729 (T) | 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.403N P=0.269N P=0.559N | P=0.302N P=0.535N P=0.535N |
|INCIDENTAL TUMOR | P=0.365N P=0.263N P=0.513N | P=0.302N P=0.535N P=0.535N |
|LOGISTIC REGRESSION | P=0.364N P=0.223N P=0.513N | P=0.302N P=0.535N P=0.535N |
|COCHRAN-ARMITAGE | P=0.363N | P=0.274N |
|FISHER EXACT | P=0.247N P=0.515N | P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/48 (4%) 4/46 (9%) 3/45 (7%) | 3/44 (7%) 1/43 (2%) 3/41 (7%) |
|ADJUSTED (b) | 5.4% 13.8% 11.2% | 8.2% 4.3% 11.6% |
|TERMINAL (d) | 1/30 (3%) 2/23 (9%) 2/23 (9%) | 1/29 (3%) 1/23 (4%) 2/23 (9%) |
|FIRST INCIDENCE (DAYS) | 587 426 660 | 646 729 (T) 721 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.330 P=0.255 P=0.422 | P=0.530 P=0.364N P=0.578 |
|INCIDENTAL TUMOR | P=0.335 P=0.348 P=0.484 | P=0.539 P=0.280N P=0.581 |
|LOGISTIC REGRESSION | P=0.367 P=0.358 P=0.466 | P=0.552 P=0.315N P=0.601 |
|COCHRAN-ARMITAGE | P=0.380 | P=0.584 |
|FISHER EXACT | P=0.318 P=0.469 | P=0.317N P=0.628 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 4.0 8.0 | VEHICLE 4.0 8.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/48 (2%) 0/46 (0%) 3/45 (7%) | 0/44 (0%) 0/43 (0%) 1/41 (2%) |
|ADJUSTED (b) | 3.3% 0.0% 9.5% | 0.0% 0.0% 4.3% |
|TERMINAL (d) | 1/30 (3%) 0/23 (0%) 1/23 (4%) | 0/29 (0%) 0/23 (0%) 1/23 (4%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 652 | --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.164 P=0.553N P=0.253 | P=0.261 (e) P=0.454 |
|INCIDENTAL TUMOR | P=0.199 P=0.553N P=0.316 | P=0.261 (e) P=0.454 |
|LOGISTIC REGRESSION | P=0.180 P=0.553N P=0.282 | P=0.261 (e) P=0.454 |
|COCHRAN-ARMITAGE | P=0.180 | P=0.280 |
|FISHER EXACT | P=0.511N P=0.284 | (e) P=0.482 |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/48 (6%) 4/46 (9%) 6/45 (13%) | 3/44 (7%) 1/43 (2%) 4/41 (10%) |
|ADJUSTED (b) | 8.7% 13.8% 19.9% | 8.2% 4.3% 15.8% |
|TERMINAL (d) | 2/30 (7%) 2/23 (9%) 3/23 (13%) | 1/29 (3%) 1/23 (4%) 3/23 (13%) |
|FIRST INCIDENCE (DAYS) | 587 426 652 | 646 729 (T) 721 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.135 P=0.390 P=0.173 | P=0.348 P=0.364N P=0.403 |
|INCIDENTAL TUMOR | P=0.149 P=0.490 P=0.240 | P=0.348 P=0.280N P=0.400 |
|LOGISTIC REGRESSION | P=0.159 P=0.514 P=0.209 | P=0.362 P=0.315N P=0.420 |
|COCHRAN-ARMITAGE | P=0.165 | P=0.401 |
|FISHER EXACT | P=0.476 P=0.211 | P=0.317N P=0.460 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 4.0 8.0 | VEHICLE 4.0 8.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 6/48 (13%) 5/50 (10%) | 1/50 (2%) 2/48 (4%) 1/50 (2%) |
|ADJUSTED (b) | 18.1% 19.3% 17.1% | 2.6% 6.6% 3.8% |
|TERMINAL (d) | 5/31 (16%) 2/25 (8%) 3/24 (13%) | 0/31 (0%) 1/26 (4%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 646 645 623 | 692 701 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.542 P=0.473 P=0.610 | P=0.557 P=0.467 P=0.715 |
|INCIDENTAL TUMOR | P=0.477N P=0.582 P=0.574N | P=0.564 P=0.498 P=0.720 |
|LOGISTIC REGRESSION | P=0.485N P=0.539 P=0.545N | P=0.588 P=0.475 P=0.744 |
|COCHRAN-ARMITAGE | P=0.445N | P=0.618 |
|FISHER EXACT | P=0.591 P=0.500N | P=0.485 P=0.753N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 6.5% 4.2% | 0.0% 0.0% 3.8% |
|TERMINAL (d) | 0/31 (0%) 1/25 (4%) 1/24 (4%) | 0/31 (0%) 0/26 (0%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | --- 645 729 (T) | --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.301 P=0.206 P=0.449 | P=0.268 (e) P=0.465 |
|INCIDENTAL TUMOR | P=0.329 P=0.234 P=0.449 | P=0.268 (e) P=0.465 |
|LOGISTIC REGRESSION | P=0.339 P=0.230 P=0.449 | P=0.268 (e) P=0.465 |
|COCHRAN-ARMITAGE | P=0.353 | P=0.290 |
|FISHER EXACT | P=0.247 P=0.500 | (e) P=0.500 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 4.0 8.0 | VEHICLE 4.0 8.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 2/50 (4%) | 0/50 (0%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 3.0% 10.4% 8.3% | 0.0% 2.9% 3.8% |
|TERMINAL (d) | 0/31 (0%) 2/25 (8%) 2/24 (8%) | 0/31 (0%) 0/26 (0%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 727 645 729 (T) | --- 704 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.306 P=0.239 P=0.409 | P=0.302 P=0.489 P=0.465 |
|INCIDENTAL TUMOR | P=0.357 P=0.296 P=0.469 | P=0.298 P=0.531 P=0.465 |
|LOGISTIC REGRESSION | P=0.349 P=0.263 P=0.407 | P=0.311 P=0.491 P=0.465 |
|COCHRAN-ARMITAGE | P=0.394 | P=0.335 |
|FISHER EXACT | P=0.309 P=0.500 | P=0.500 P=0.500 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 2/50 (4%) | 0/50 (0%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 3.0% 10.4% 8.3% | 0.0% 2.9% 3.8% |
|TERMINAL (d) | 0/31 (0%) 2/25 (8%) 2/24 (8%) | 0/31 (0%) 0/26 (0%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 727 645 729 (T) | --- 704 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.306 P=0.239 P=0.409 | P=0.302 P=0.489 P=0.465 |
|INCIDENTAL TUMOR | P=0.357 P=0.296 P=0.469 | P=0.298 P=0.531 P=0.465 |
|LOGISTIC REGRESSION | P=0.349 P=0.263 P=0.407 | P=0.311 P=0.491 P=0.465 |
|COCHRAN-ARMITAGE | P=0.394 | P=0.335 |
|FISHER EXACT | P=0.309 P=0.500 | P=0.500 P=0.500 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 4.0 8.0 | VEHICLE 4.0 8.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 3/49 (6%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 11.2% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/25 (0%) 2/23 (9%) | 0/31 (0%) 0/26 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 660 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.033 * (e) P=0.088 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.036 * (e) P=0.101 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.037 * (e) P=0.104 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.041 * | (e) |
|FISHER EXACT | (e) P=0.117 | (e) (e) |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 2/50 (4%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 4.9% 7.7% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/25 (0%) 0/24 (0%) | 0/31 (0%) 2/26 (8%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 677 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.237N P=0.649 P=0.287N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.225N P=0.691 P=0.276N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.204N P=0.677 P=0.234N |
|COCHRAN-ARMITAGE | (e) | P=0.187N |
|FISHER EXACT | (e) (e) | P=0.691N P=0.247N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 4.0 8.0 | VEHICLE 4.0 8.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 2/50 (4%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 4.9% 7.7% 3.8% |
|TERMINAL (d) | 0/31 (0%) 0/25 (0%) 0/24 (0%) | 0/31 (0%) 2/26 (8%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 677 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.471N P=0.649 P=0.568N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.464N P=0.691 P=0.563N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.434N P=0.677 P=0.517N |
|COCHRAN-ARMITAGE | (e) | P=0.401N |
|FISHER EXACT | (e) (e) | P=0.691N P=0.500N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 1/50 (2%) 2/50 (4%) | 9/50 (18%) 19/50 (38%) 16/50 (32%) |
|ADJUSTED (b) | 17.4% 3.2% 6.2% | 24.5% 62.4% 45.6% |
|TERMINAL (d) | 4/31 (13%) 0/25 (0%) 0/24 (0%) | 6/31 (19%) 15/26 (58%) 8/26 (31%) |
|FIRST INCIDENCE (DAYS) | 646 684 660 | 547 545 582 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.117N P=0.105N P=0.218N | P=0.030 * P=0.007 ** P=0.047 * |
|INCIDENTAL TUMOR | P=0.061N P=0.066N P=0.134N | P=0.049 * P=0.010 ** P=0.077 |
|LOGISTIC REGRESSION | P=0.078N P=0.078N P=0.154N | P=0.045 * P=0.015 * P=0.070 |
|COCHRAN-ARMITAGE | P=0.066N | P=0.070 |
|FISHER EXACT | P=0.056N P=0.134N | P=0.022 * P=0.083 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 4.0 8.0 | VEHICLE 4.0 8.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 1/50 (2%) 2/50 (4%) | 9/50 (18%) 19/50 (38%) 17/50 (34%) |
|ADJUSTED (b) | 17.4% 3.2% 6.2% | 24.5% 62.4% 48.6% |
|TERMINAL (d) | 4/31 (13%) 0/25 (0%) 0/24 (0%) | 6/31 (19%) 15/26 (58%) 9/26 (35%) |
|FIRST INCIDENCE (DAYS) | 646 684 660 | 547 545 582 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.117N P=0.105N P=0.218N | P=0.019 * P=0.007 ** P=0.030 * |
|INCIDENTAL TUMOR | P=0.061N P=0.066N P=0.134N | P=0.030 * P=0.010 ** P=0.049 * |
|LOGISTIC REGRESSION | P=0.078N P=0.078N P=0.154N | P=0.028 * P=0.015 * P=0.044 * |
|COCHRAN-ARMITAGE | P=0.066N | P=0.046 * |
|FISHER EXACT | P=0.056N P=0.134N | P=0.022 * P=0.055 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 1/50 (2%) 2/50 (4%) | 11/50 (22%) 20/50 (40%) 17/50 (34%) |
|ADJUSTED (b) | 17.4% 3.2% 6.2% | 28.2% 65.8% 48.6% |
|TERMINAL (d) | 4/31 (13%) 0/25 (0%) 0/24 (0%) | 6/31 (19%) 16/26 (62%) 9/26 (35%) |
|FIRST INCIDENCE (DAYS) | 646 684 660 | 547 545 582 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.117N P=0.105N P=0.218N | P=0.049 * P=0.015 * P=0.074 |
|INCIDENTAL TUMOR | P=0.061N P=0.066N P=0.134N | P=0.074 P=0.022 * P=0.112 |
|LOGISTIC REGRESSION | P=0.078N P=0.078N P=0.154N | P=0.072 P=0.028 * P=0.113 |
|COCHRAN-ARMITAGE | P=0.066N | P=0.111 |
|FISHER EXACT | P=0.056N P=0.134N | P=0.041 * P=0.133 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 4.0 8.0 | VEHICLE 4.0 8.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 4.2% | 0.0% 0.0% 5.8% |
|TERMINAL (d) | 0/31 (0%) 0/25 (0%) 1/24 (4%) | 0/31 (0%) 0/26 (0%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | --- --- 729 (T) | --- --- 383 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.257 (e) P=0.449 | P=0.100 (e) P=0.220 |
|INCIDENTAL TUMOR | P=0.257 (e) P=0.449 | P=0.132 (e) P=0.291 |
|LOGISTIC REGRESSION | P=0.257 (e) P=0.449 | P=0.106 (e) P=0.320 |
|COCHRAN-ARMITAGE | P=0.290 | P=0.106 |
|FISHER EXACT | (e) P=0.500 | (e) P=0.247 |
|=================================================================================================================================|
| |
|Ovary |
| Granulosa Cell Tumor |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | | 5.5% 0.0% 0.0% |
|TERMINAL (d) | | 1/31 (3%) 0/26 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | | 646 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.116N P=0.267N P=0.279N |
|INCIDENTAL TUMOR | | P=0.110N P=0.241N P=0.280N |
|LOGISTIC REGRESSION | | P=0.095N P=0.238N P=0.237N |
|COCHRAN-ARMITAGE | | P=0.094N |
|FISHER EXACT | | P=0.247N P=0.247N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 4.0 8.0 | VEHICLE 4.0 8.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Pancreas |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 16/50 (32%) 25/49 (51%) 30/50 (60%) | 1/50 (2%) 1/47 (2%) 4/50 (8%) |
|ADJUSTED (b) | 45.2% 80.0% 82.5% | 3.2% 4.0% 12.5% |
|TERMINAL (d) | 12/31 (39%) 19/25 (76%) 18/24 (75%) | 1/31 (3%) 1/25 (4%) 2/26 (8%) |
|FIRST INCIDENCE (DAYS) | 653 533 564 | 729 (T) 729 (T) 631 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.006 ** P<0.001 ** | P=0.085 P=0.714 P=0.140 |
|INCIDENTAL TUMOR | P<0.001 ** P=0.013 * P=0.001 ** | P=0.138 P=0.714 P=0.226 |
|LOGISTIC REGRESSION | P<0.001 ** P=0.007 ** P=0.001 ** | P=0.102 P=0.714 P=0.171 |
|COCHRAN-ARMITAGE | P=0.003 ** | P=0.111 |
|FISHER EXACT | P=0.043 * P=0.004 ** | P=0.737 P=0.181 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/50 (18%) 11/48 (23%) 7/49 (14%) | 27/50 (54%) 19/49 (39%) 19/50 (38%) |
|ADJUSTED (b) | 26.0% 31.6% 22.8% | 63.7% 54.3% 58.3% |
|TERMINAL (d) | 6/31 (19%) 4/24 (17%) 4/24 (17%) | 16/31 (52%) 11/26 (42%) 13/26 (50%) |
|FIRST INCIDENCE (DAYS) | 674 426 592 | 547 545 486 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.539N P=0.235 P=0.572N | P=0.228N P=0.258N P=0.265N |
|INCIDENTAL TUMOR | P=0.372N P=0.458 P=0.447N | P=0.114N P=0.117N P=0.151N |
|LOGISTIC REGRESSION | P=0.373N P=0.386 P=0.454N | P=0.098N P=0.115N P=0.124N |
|COCHRAN-ARMITAGE | P=0.382N | P=0.063N |
|FISHER EXACT | P=0.362 P=0.410N | P=0.094N P=0.080N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 4.0 8.0 | VEHICLE 4.0 8.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/48 (0%) 2/49 (4%) | 1/50 (2%) 2/49 (4%) 4/50 (8%) |
|ADJUSTED (b) | 2.0% 0.0% 6.4% | 2.9% 7.7% 11.5% |
|TERMINAL (d) | 0/31 (0%) 0/24 (0%) 1/24 (4%) | 0/31 (0%) 2/26 (8%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 393 --- 621 | 711 729 (T) 557 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.364 P=0.500N P=0.473 | P=0.105 P=0.434 P=0.160 |
|INCIDENTAL TUMOR | P=0.415 P=0.318N P=0.550 | P=0.113 P=0.477 P=0.172 |
|LOGISTIC REGRESSION | P=0.403 P=0.386 P=0.541 | P=0.119 P=0.470 P=0.189 |
|COCHRAN-ARMITAGE | P=0.379 | P=0.123 |
|FISHER EXACT | P=0.510N P=0.492 | P=0.492 P=0.181 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 11/48 (23%) 9/49 (18%) | 28/50 (56%) 21/49 (43%) 23/50 (46%) |
|ADJUSTED (b) | 27.5% 31.6% 28.4% | 64.8% 60.4% 64.6% |
|TERMINAL (d) | 6/31 (19%) 4/24 (17%) 5/24 (21%) | 16/31 (52%) 13/26 (50%) 14/26 (54%) |
|FIRST INCIDENCE (DAYS) | 393 426 592 | 547 545 486 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.466 P=0.318 P=0.520 | P=0.439N P=0.337N P=0.481N |
|INCIDENTAL TUMOR | P=0.457N P=0.599N P=0.529N | P=0.284N P=0.166N P=0.340N |
|LOGISTIC REGRESSION | P=0.452N P=0.535 P=0.517N | P=0.252N P=0.165N P=0.289N |
|COCHRAN-ARMITAGE | P=0.481N | P=0.177N |
|FISHER EXACT | P=0.458 P=0.520N | P=0.134N P=0.212N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 4.0 8.0 | VEHICLE 4.0 8.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/48 (0%) 0/49 (0%) | 0/50 (0%) 1/49 (2%) 1/50 (2%) |
|ADJUSTED (b) | 4.4% 0.0% 0.0% | 0.0% 3.8% 2.5% |
|TERMINAL (d) | 0/31 (0%) 0/24 (0%) 0/24 (0%) | 0/31 (0%) 1/26 (4%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 576 --- --- | --- 729 (T) 630 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.108N P=0.269N P=0.258N | P=0.310 P=0.465 P=0.486 |
|INCIDENTAL TUMOR | P=0.072N P=0.221N P=0.184N | P=0.397 P=0.465 P=0.638 |
|LOGISTIC REGRESSION | P=0.080N P=0.191N P=0.216N | P=0.337 P=0.465 P=0.537 |
|COCHRAN-ARMITAGE | P=0.097N | P=0.335 |
|FISHER EXACT | P=0.258N P=0.253N | P=0.495 P=0.500 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/48 (0%) 0/49 (0%) | 1/50 (2%) 1/49 (2%) 1/50 (2%) |
|ADJUSTED (b) | 4.4% 0.0% 0.0% | 2.0% 3.8% 2.5% |
|TERMINAL (d) | 0/31 (0%) 0/24 (0%) 0/24 (0%) | 0/31 (0%) 1/26 (4%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 576 --- --- | 404 729 (T) 630 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.108N P=0.269N P=0.258N | P=0.620 P=0.736 P=0.750 |
|INCIDENTAL TUMOR | P=0.072N P=0.221N P=0.184N | P=0.535N P=0.737N P=0.599N |
|LOGISTIC REGRESSION | P=0.080N P=0.191N P=0.216N | P=0.611N P=0.704N P=0.658N |
|COCHRAN-ARMITAGE | P=0.097N | P=0.647 |
|FISHER EXACT | P=0.258N P=0.253N | P=0.747 P=0.753N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 4.0 8.0 | VEHICLE 4.0 8.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Prostate |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/49 (0%) | |
|ADJUSTED (b) | 6.0% 4.0% 0.0% | |
|TERMINAL (d) | 1/31 (3%) 1/25 (4%) 0/24 (0%) | |
|FIRST INCIDENCE (DAYS) | 719 729 (T) --- | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.204N P=0.588N P=0.302N | |
|INCIDENTAL TUMOR | P=0.166N P=0.530N P=0.240N | |
|LOGISTIC REGRESSION | P=0.191N P=0.592N P=0.276N | |
|COCHRAN-ARMITAGE | P=0.150N | |
|FISHER EXACT | P=0.500N P=0.253N | |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 4.0% 7.9% | 0.0% 0.0% 3.8% |
|TERMINAL (d) | 0/31 (0%) 1/25 (4%) 1/24 (4%) | 0/31 (0%) 0/26 (0%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 719 | --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.110 P=0.457 P=0.181 | P=0.268 (e) P=0.465 |
|INCIDENTAL TUMOR | P=0.134 P=0.457 P=0.236 | P=0.268 (e) P=0.465 |
|LOGISTIC REGRESSION | P=0.117 P=0.457 P=0.197 | P=0.268 (e) P=0.465 |
|COCHRAN-ARMITAGE | P=0.147 | P=0.290 |
|FISHER EXACT | P=0.500 P=0.247 | (e) P=0.500 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 4.0 8.0 | VEHICLE 4.0 8.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 4/50 (8%) 1/50 (2%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 9.7% 12.5% 2.8% | 3.2% 0.0% 0.0% |
|TERMINAL (d) | 3/31 (10%) 2/25 (8%) 0/24 (0%) | 1/31 (3%) 0/26 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 607 667 | 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.347N P=0.410 P=0.381N | P=0.302N P=0.535N P=0.535N |
|INCIDENTAL TUMOR | P=0.283N P=0.416 P=0.353N | P=0.302N P=0.535N P=0.535N |
|LOGISTIC REGRESSION | P=0.283N P=0.459 P=0.338N | P=0.302N P=0.535N P=0.535N |
|COCHRAN-ARMITAGE | P=0.268N | P=0.274N |
|FISHER EXACT | P=0.500 P=0.309N | P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 3/50 (6%) 2/50 (4%) | 1/50 (2%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 8.4% 12.0% 6.2% | 3.2% 3.8% 3.8% |
|TERMINAL (d) | 2/31 (6%) 3/25 (12%) 1/24 (4%) | 1/31 (3%) 1/26 (4%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 576 729 (T) 564 | 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.520N P=0.569 P=0.577N | P=0.596 P=0.723 P=0.723 |
|INCIDENTAL TUMOR | P=0.465N P=0.578 P=0.497N | P=0.596 P=0.723 P=0.723 |
|LOGISTIC REGRESSION | P=0.430N P=0.620 P=0.478N | P=0.596 P=0.723 P=0.723 |
|COCHRAN-ARMITAGE | P=0.421N | P=0.647 |
|FISHER EXACT | P=0.661N P=0.500N | P=0.753N P=0.753N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 4.0 8.0 | VEHICLE 4.0 8.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Basal Cell Carcinoma, or Basal Cell Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 3/50 (6%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 2.0% 4.0% 11.9% | 0.0% 0.0% 3.8% |
|TERMINAL (d) | 0/31 (0%) 1/25 (4%) 2/24 (8%) | 0/31 (0%) 0/26 (0%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 522 729 (T) 719 | --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.161 P=0.727 P=0.236 | P=0.268 (e) P=0.465 |
|INCIDENTAL TUMOR | P=0.194 P=0.677N P=0.318 | P=0.268 (e) P=0.465 |
|LOGISTIC REGRESSION | P=0.210 P=0.722N P=0.315 | P=0.268 (e) P=0.465 |
|COCHRAN-ARMITAGE | P=0.213 | P=0.290 |
|FISHER EXACT | P=0.753N P=0.309 | (e) P=0.500 |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 8/50 (16%) 6/50 (12%) | 2/50 (4%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 19.6% 27.7% 19.9% | 6.5% 3.8% 7.7% |
|TERMINAL (d) | 5/31 (16%) 6/25 (24%) 3/24 (13%) | 2/31 (6%) 1/26 (4%) 2/26 (8%) |
|FIRST INCIDENCE (DAYS) | 522 607 564 | 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.503 P=0.356 P=0.586 | P=0.558 P=0.562N P=0.631 |
|INCIDENTAL TUMOR | P=0.501N P=0.423 P=0.521N | P=0.558 P=0.562N P=0.631 |
|LOGISTIC REGRESSION | P=0.472N P=0.467 P=0.492N | P=0.558 P=0.562N P=0.631 |
|COCHRAN-ARMITAGE | P=0.453N | P=0.608N |
|FISHER EXACT | P=0.500 P=0.500N | P=0.500N P=0.691N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 4.0 8.0 | VEHICLE 4.0 8.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 6/50 (12%) 4/50 (8%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 18.5% 20.6% 16.7% | 0.0% 0.0% 7.7% |
|TERMINAL (d) | 4/31 (13%) 4/25 (16%) 4/24 (17%) | 0/31 (0%) 0/26 (0%) 2/26 (8%) |
|FIRST INCIDENCE (DAYS) | 576 644 729 (T) | --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.349N P=0.599 P=0.390N | P=0.091 (e) P=0.200 |
|INCIDENTAL TUMOR | P=0.269N P=0.582N P=0.314N | P=0.091 (e) P=0.200 |
|LOGISTIC REGRESSION | P=0.245N P=0.522N P=0.272N | P=0.091 (e) P=0.200 |
|COCHRAN-ARMITAGE | P=0.220N | P=0.106 |
|FISHER EXACT | P=0.500N P=0.262N | (e) P=0.247 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 2/50 (4%) | 0/50 (0%) 3/50 (6%) 1/50 (2%) |
|ADJUSTED (b) | 6.5% 0.0% 8.3% | 0.0% 9.0% 3.8% |
|TERMINAL (d) | 2/31 (6%) 0/25 (0%) 2/24 (8%) | 0/31 (0%) 0/26 (0%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 729 (T) | --- 695 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.562 P=0.286N P=0.600 | P=0.317 P=0.107 P=0.465 |
|INCIDENTAL TUMOR | P=0.562 P=0.286N P=0.600 | P=0.306 P=0.143 P=0.465 |
|LOGISTIC REGRESSION | P=0.562 P=0.286N P=0.600 | P=0.091 P=0.112 P=0.465 |
|COCHRAN-ARMITAGE | P=0.610N | P=0.362 |
|FISHER EXACT | P=0.247N P=0.691N | P=0.121 P=0.500 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 4.0 8.0 | VEHICLE 4.0 8.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 9/50 (18%) 6/50 (12%) 6/50 (12%) | 0/50 (0%) 3/50 (6%) 3/50 (6%) |
|ADJUSTED (b) | 24.6% 20.6% 25.0% | 0.0% 9.0% 11.5% |
|TERMINAL (d) | 6/31 (19%) 4/25 (16%) 6/24 (25%) | 0/31 (0%) 0/26 (0%) 3/26 (12%) |
|FIRST INCIDENCE (DAYS) | 576 644 729 (T) | --- 695 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.390N P=0.429N P=0.458N | P=0.076 P=0.107 P=0.091 |
|INCIDENTAL TUMOR | P=0.313N P=0.379N P=0.388N | P=0.069 P=0.143 P=0.091 |
|LOGISTIC REGRESSION | P=0.276N P=0.323N P=0.324N | P=0.019 * P=0.112 P=0.091 |
|COCHRAN-ARMITAGE | P=0.233N | P=0.099 |
|FISHER EXACT | P=0.288N P=0.288N | P=0.121 P=0.121 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Schwannoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 6.5% 2.1% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/31 (6%) 0/25 (0%) 0/24 (0%) | 0/31 (0%) 0/26 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 477 --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.184N P=0.555N P=0.296N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.148N P=0.431N P=0.296N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.131N P=0.453N P=0.296N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.147N | (e) |
|FISHER EXACT | P=0.500N P=0.247N | (e) (e) |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 4.0 8.0 | VEHICLE 4.0 8.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 6.5% 4.0% 0.0% | 0.0% 3.8% 0.0% |
|TERMINAL (d) | 2/31 (6%) 1/25 (4%) 0/24 (0%) | 0/31 (0%) 1/26 (4%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) --- | --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.197N P=0.575N P=0.296N | P=0.698 P=0.465 (e) |
|INCIDENTAL TUMOR | P=0.197N P=0.575N P=0.296N | P=0.698 P=0.465 (e) |
|LOGISTIC REGRESSION | P=0.197N P=0.575N P=0.296N | P=0.698 P=0.465 (e) |
|COCHRAN-ARMITAGE | P=0.147N | P=0.726 |
|FISHER EXACT | P=0.500N P=0.247N | P=0.500 (e) |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 45/50 (90%) 46/50 (92%) 46/50 (92%) | |
|ADJUSTED (b) | 97.8% 100.0% 97.8% | |
|TERMINAL (d) | 30/31 (97%) 25/25 (100%) 23/24 (96%) | |
|FIRST INCIDENCE (DAYS) | 522 468 461 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.069 P=0.078 P=0.079 | |
|INCIDENTAL TUMOR | P=0.279 P=0.208 P=0.362 | |
|LOGISTIC REGRESSION | P=0.323 P=0.185 P=0.427 | |
|COCHRAN-ARMITAGE | P=0.431 | |
|FISHER EXACT | P=0.500 P=0.500 | |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 4.0 8.0 | VEHICLE 4.0 8.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/49 (12%) 9/49 (18%) 8/49 (16%) | 5/50 (10%) 7/49 (14%) 5/50 (10%) |
|ADJUSTED (b) | 18.3% 28.4% 24.8% | 14.8% 21.8% 15.3% |
|TERMINAL (d) | 5/31 (16%) 4/25 (16%) 3/23 (13%) | 4/31 (13%) 3/26 (12%) 2/26 (8%) |
|FIRST INCIDENCE (DAYS) | 674 653 623 | 596 656 631 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.200 P=0.175 P=0.243 | P=0.447 P=0.295 P=0.525 |
|INCIDENTAL TUMOR | P=0.334 P=0.241 P=0.389 | P=0.509 P=0.345 P=0.626 |
|LOGISTIC REGRESSION | P=0.290 P=0.212 P=0.353 | P=0.517 P=0.341 P=0.610 |
|COCHRAN-ARMITAGE | P=0.333 | P=0.556 |
|FISHER EXACT | P=0.288 P=0.387 | P=0.365 P=0.630N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/49 (12%) 10/49 (20%) 8/49 (16%) | 5/50 (10%) 8/49 (16%) 5/50 (10%) |
|ADJUSTED (b) | 18.3% 31.8% 24.8% | 14.8% 25.2% 15.3% |
|TERMINAL (d) | 5/31 (16%) 5/25 (20%) 3/23 (13%) | 4/31 (13%) 4/26 (15%) 2/26 (8%) |
|FIRST INCIDENCE (DAYS) | 674 653 623 | 596 656 631 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.193 P=0.114 P=0.243 | P=0.436 P=0.202 P=0.525 |
|INCIDENTAL TUMOR | P=0.323 P=0.160 P=0.389 | P=0.497 P=0.240 P=0.626 |
|LOGISTIC REGRESSION | P=0.284 P=0.138 P=0.353 | P=0.505 P=0.239 P=0.610 |
|COCHRAN-ARMITAGE | P=0.332 | P=0.550 |
|FISHER EXACT | P=0.207 P=0.387 | P=0.264 P=0.630N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 4.0 8.0 | VEHICLE 4.0 8.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 15/50 (30%) 14/50 (28%) 13/50 (26%) |
|ADJUSTED (b) | | 39.8% 43.5% 34.7% |
|TERMINAL (d) | | 10/31 (32%) 9/26 (35%) 4/26 (15%) |
|FIRST INCIDENCE (DAYS) | | 582 556 582 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.534 P=0.499 P=0.579N |
|INCIDENTAL TUMOR | | P=0.373N P=0.576 P=0.369N |
|LOGISTIC REGRESSION | | P=0.423N P=0.560N P=0.434N |
|COCHRAN-ARMITAGE | | P=0.372N |
|FISHER EXACT | | P=0.500N P=0.412N |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | | 0.0% 0.0% 5.0% |
|TERMINAL (d) | | 0/31 (0%) 0/26 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | | --- --- 587 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.098 (e) P=0.218 |
|INCIDENTAL TUMOR | | P=0.138 (e) P=0.290 |
|LOGISTIC REGRESSION | | P=0.110 (e) P=0.281 |
|COCHRAN-ARMITAGE | | P=0.106 |
|FISHER EXACT | | (e) P=0.247 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 4.0 8.0 | VEHICLE 4.0 8.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 15/50 (30%) 14/50 (28%) 14/50 (28%) |
|ADJUSTED (b) | | 39.8% 43.5% 36.2% |
|TERMINAL (d) | | 10/31 (32%) 9/26 (35%) 4/26 (15%) |
|FIRST INCIDENCE (DAYS) | | 582 556 582 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.454 P=0.499 P=0.499 |
|INCIDENTAL TUMOR | | P=0.437N P=0.576 P=0.427N |
|LOGISTIC REGRESSION | | P=0.501N P=0.560N P=0.507N |
|COCHRAN-ARMITAGE | | P=0.457N |
|FISHER EXACT | | P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 11/50 (22%) 20/50 (40%) 21/50 (42%) | 17/50 (34%) 21/50 (42%) 23/50 (46%) |
|ADJUSTED (b) | 31.7% 59.0% 57.1% | 39.1% 53.2% 56.8% |
|TERMINAL (d) | 8/31 (26%) 12/25 (48%) 9/24 (38%) | 7/31 (23%) 9/26 (35%) 9/26 (35%) |
|FIRST INCIDENCE (DAYS) | 595 607 610 | 532 519 546 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.006 ** P=0.012 * P=0.008 ** | P=0.082 P=0.186 P=0.100 |
|INCIDENTAL TUMOR | P=0.018 * P=0.019 * P=0.026 * | P=0.169 P=0.262 P=0.202 |
|LOGISTIC REGRESSION | P=0.011 * P=0.016 * P=0.016 * | P=0.146 P=0.231 P=0.176 |
|COCHRAN-ARMITAGE | P=0.022 * | P=0.131 |
|FISHER EXACT | P=0.041 * P=0.026 * | P=0.268 P=0.154 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 4.0 8.0 | VEHICLE 4.0 8.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 6.2% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/25 (0%) 1/24 (4%) | 0/31 (0%) 0/26 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 564 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.096 (e) P=0.210 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.119 (e) P=0.253 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.108 (e) P=0.253 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.106 | (e) |
|FISHER EXACT | (e) P=0.247 | (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 6.2% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/25 (0%) 1/24 (4%) | 0/31 (0%) 0/26 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 564 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.096 (e) P=0.210 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.119 (e) P=0.253 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.108 (e) P=0.253 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.106 | (e) |
|FISHER EXACT | (e) P=0.247 | (e) (e) |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 24
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 4.0 8.0 | VEHICLE 4.0 8.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 8.7% 7.3% 2.4% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/31 (6%) 1/25 (4%) 0/24 (0%) | 0/31 (0%) 0/26 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 651 691 623 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.287N P=0.591N P=0.361N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.225N P=0.528N P=0.294N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.236N P=0.549N P=0.300N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.227N | (e) |
|FISHER EXACT | P=0.500N P=0.309N | (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 49/50 (98%) 49/50 (98%) 49/50 (98%) | 40/50 (80%) 40/50 (80%) 39/50 (78%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 88.7% 93.0% 90.6% |
|TERMINAL (d) | 31/31 (100%) 25/25 (100%) 24/24 (100%) | 26/31 (84%) 23/26 (88%) 22/26 (85%) |
|FIRST INCIDENCE (DAYS) | 522 426 461 | 547 545 486 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.094 P=0.108 P=0.100 | P=0.225 P=0.228 P=0.266 |
|INCIDENTAL TUMOR | P=0.560 P=0.500 P=0.667 | P=0.429 P=0.356 P=0.550 |
|LOGISTIC REGRESSION | P=0.672 P=0.500 P=0.764 | P=0.432 P=0.393 P=0.518 |
|COCHRAN-ARMITAGE | P=0.647 | P=0.456N |
|FISHER EXACT | P=0.753N P=0.753N | P=0.598N P=0.500N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 25
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 4.0 8.0 | VEHICLE 4.0 8.0 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 25/50 (50%) 29/50 (58%) 32/50 (64%) | 23/50 (46%) 32/50 (64%) 30/50 (60%) |
|ADJUSTED (b) | 59.0% 79.7% 75.3% | 48.6% 73.8% 67.6% |
|TERMINAL (d) | 14/31 (45%) 18/25 (72%) 14/24 (58%) | 8/31 (26%) 15/26 (58%) 12/26 (46%) |
|FIRST INCIDENCE (DAYS) | 393 477 564 | 404 446 383 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.028 * P=0.085 P=0.041 * | P=0.060 P=0.049 * P=0.081 |
|INCIDENTAL TUMOR | P=0.086 P=0.199 P=0.141 | P=0.112 P=0.050 * P=0.167 |
|LOGISTIC REGRESSION | P=0.066 P=0.170 P=0.100 | P=0.121 P=0.042 * P=0.181 |
|COCHRAN-ARMITAGE | P=0.095 | P=0.089 |
|FISHER EXACT | P=0.274 P=0.113 | P=0.054 P=0.115 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 50/50 (100%) 49/50 (98%) 50/50 (100%) | 47/50 (94%) 46/50 (92%) 46/50 (92%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 94.0% 95.8% 93.9% |
|TERMINAL (d) | 31/31 (100%) 25/25 (100%) 24/24 (100%) | 28/31 (90%) 24/26 (92%) 23/26 (88%) |
|FIRST INCIDENCE (DAYS) | 393 426 461 | 404 446 383 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.098 P=0.142 P=0.106 | P=0.220 P=0.267 P=0.253 |
|INCIDENTAL TUMOR | P=0.758 P=0.718N (e) | P=0.387N P=0.581 P=0.469N |
|LOGISTIC REGRESSION | P=0.535N P=0.517N (e) | P=0.501N P=0.662N P=0.502N |
|COCHRAN-ARMITAGE | P=0.726N | P=0.425N |
|FISHER EXACT | P=0.500N P=1.000N | P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05049 TEST: 01 PAGE 26
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DICHLORVOS
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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