TDMS Study 05049-01 Pathology Tables
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
Facility: Southern Research Institute
Chemical CAS #: 62-73-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 0| 0| 1| 3| 3| 1| 3| 3| 3| 3| 5| 9| 9| 3| 3| 0| 3| 3| 3| 3| 4| 8| 3| 3| 3|
| 2| 8| 1| 4| 4| 4| 4| 4| 4| 4| 1| 2| 5| 4| 4| 2| 4| 4| 4| 5| 7| 2| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + I + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cecum, Parasite Metazoan | 2|
Colon, Parasite Metazoan | 2 2 2|
Rectum, Parasite Metazoan | 2 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic | 2 2 2 2 1 1 1 |
Inflammation, Chronic Active | |
Inflammation, Granulomatous | 2 2 |
Mixed Cell Focus | |
Bile Duct, Hyperplasia | 3 3 2 2 2 2 4 2 2 3 1 1 2 3 |
Hepatocyte, Atrophy, Multifocal | 3 |
Hepatocyte, Cytoplasmic Alteration | 3 |
Hepatocyte, Hyperplasia, Nodular | |
Hepatocyte, Necrosis, Multifocal | 3 |
Hepatocyte, Vacuolization Cytoplasmic| 2 3 3 3 |
Kupffer Cell, Hyperplasia | |
Kupffer Cell, Pigmentation | 2 2 4 3 |
Portal, Fibrosis | 2 2 2 1 4 2 2 3 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Mineralization | 3 3 |
Fat, Necrosis, Focal | 4 4 2 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
Cyst | X |
Cytoplasmic Alteration | |
Hyperplasia | |
__________________________________________________________________________|
Pharynx | + |
Palate, Inflammation, Suppurative | 3 |
Palate, Necrosis | 3 |
__________________________________________________________________________|
Salivary Glands | + + M + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Diverticulum | |
Forestomach, Edema | 3 |
Forestomach, Inflammation, Chronic | |
Active | 3 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 0| 0| 1| 3| 3| 1| 3| 3| 3| 3| 5| 9| 9| 3| 3| 0| 3| 3| 3| 3| 4| 8| 3| 3| 3|
| 2| 8| 1| 4| 4| 4| 4| 4| 4| 4| 1| 2| 5| 4| 4| 2| 4| 4| 4| 5| 7| 2| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Forestomach, Ulcer | 3 3 3 |
Forestomach, Mucosa, Dysplasia | |
Forestomach, Mucosa, Hyperplasia | 2 3 3 2 |
Glandular, Dysplasia | |
Glandular, Edema | 3 |
Glandular, Erosion | 3 2 |
Glandular, Mineralization | 2 2 |
Glandular, Ulcer | 3 |
__________________________________________________________________________|
Tongue | + |
Inflammation, Suppurative | |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Fibrosis | 3 2 2 2 2 2 2 2 2 3 3|
Myocardium, Inflammation, Chronic | 2 3 3 |
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Infiltration Cellular, Eosinophil | 2 |
Inflammation, Chronic | 2 3 |
Cortex, Congestion | |
Cortex, Cyst | X |
Cortex, Hyperplasia | |
Cortex, Necrosis | 3 |
Cortex, Pigmentation | 3 |
Cortex, Vacuolization Cytoplasmic | 2 2 2 |
Medulla, Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X X X X X X X X |
Pars Distalis, Hyperplasia | 2 2 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 3 3 2 2 2 3 2 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 0| 0| 1| 3| 3| 1| 3| 3| 3| 3| 5| 9| 9| 3| 3| 0| 3| 3| 3| 3| 4| 8| 3| 3| 3|
| 2| 8| 1| 4| 4| 4| 4| 4| 4| 4| 1| 2| 5| 4| 4| 2| 4| 4| 4| 5| 7| 2| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + M + + M + + + + + + + + + + + + + + +|
Ectasia | 3 4 |
Hyperplasia | 4 4 |
Inflammation, Suppurative | 2 2 2 3 2|
Metaplasia, Squamous | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Hydrometra | 2 |
Inflammation, Suppurative | 2 2 |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Vagina | + + + |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
Hyperplasia, Reticulum Cell | 2 1 3 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Hyperplasia, Lymphoid | |
Axillary, Inflammation, Suppurative | |
Axillary, Lymphatic, Ectasia | |
Bronchial, Hemorrhage | 2 |
Bronchial, Infiltration Cellular, | |
Mast Cell | 3 |
Lymphatic, Mandibular, Ectasia | 2 |
Mandibular, Hyperplasia, Plasma Cell | 2 3 |
Mediastinal, Erythrophagocytosis | 3 3 |
Mediastinal, Hemorrhage | 2 3 |
Mediastinal, Hyperplasia, Plasma Cell| |
Mediastinal, Infiltration Cellular, | |
Mast Cell | 3 |
Mediastinal, Pigmentation | 2 3 3 2 3 3 3 |
Mesenteric, Atrophy | |
Mesenteric, Erythrophagocytosis | |
Mesenteric, Hemorrhage | 3 |
Mesenteric, Hyperplasia, Histiocytic | |
Mesenteric, Infiltration Cellular, | |
Mast Cell | 3 3 |
Mesenteric, Pigmentation | |
Pancreatic, Hyperplasia, Histiocytic | 3 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 0| 0| 1| 3| 3| 1| 3| 3| 3| 3| 5| 9| 9| 3| 3| 0| 3| 3| 3| 3| 4| 8| 3| 3| 3|
| 2| 8| 1| 4| 4| 4| 4| 4| 4| 4| 1| 2| 5| 4| 4| 2| 4| 4| 4| 5| 7| 2| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Erythrophagocytosis | |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Granulocytic | 3 3 |
Hematopoietic Cell Proliferation | |
Erythrocytic | 2 3 |
Pigmentation, Hemosiderin | 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + M + + + M + M M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 3 3 1 2 2 2 2 2 3 1 2 4 2 2 2 4 1 1|
Hyperplasia, Lobular | |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
Inflammation, Chronic | |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 2 |
Degeneration, Multiple | 3 2 3 2 |
Hydrocephalus | 2 |
Cerebrum, Degeneration | 1 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | 2 |
Edema, Diffuse | 3 |
Fibrosis | 2 |
Foreign Body | 4 |
Hemorrhage | 3 3|
Infiltration Cellular, Histiocyte | 2 2 2 1 2 1 2 1 2 2 1 1 1 1 1 1 1 1 1 4|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 0| 0| 1| 3| 3| 1| 3| 3| 3| 3| 5| 9| 9| 3| 3| 0| 3| 3| 3| 3| 4| 8| 3| 3| 3|
| 2| 8| 1| 4| 4| 4| 4| 4| 4| 4| 1| 2| 5| 4| 4| 2| 4| 4| 4| 5| 7| 2| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic | |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Fungus | |
Lumen, Inflammation, Suppurative | |
Mucosa, Metaplasia, Squamous | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 2 |
Submucosa, Inflammation, Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + M |
Cataract | 4 |
Retina, Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 2 |
Inflammation, Suppurative | 2 |
Nephropathy | 1 2 1 1 1 1 1 1 2 2 1 1 1 1 1 1|
Pelvis, Mineralization | 1 2 1 2 2 1 1 2 |
Renal Tubule, Mineralization | 2 1 1 1 |
Renal Tubule, Necrosis | 4 |
Renal Tubule, Pigmentation | 3 2 2 3 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Chronic | |
Mucosa, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 4| 3| 3| 7| 3| 3| 3| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 1| 3| 3| |
| 4| 2| 6| 5| 5| 7| 5| 5| 5| 5| 6| 1| 5| 5| 5| 5| 5| 5| 5| 4| 2| 4| 1| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cecum, Parasite Metazoan | 2 | 2 2.0|
Colon, Parasite Metazoan | 2 2 | 5 2.0|
Rectum, Parasite Metazoan | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 2 | 3 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X| 32 |
Clear Cell Focus | | 1 |
Hematopoietic Cell Proliferation | 2 2 | 3 2.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Inflammation, Chronic | 3 | 8 1.8|
Inflammation, Chronic Active | 1 | 1 1.0|
Inflammation, Granulomatous | 1 2 2 2 4 2 1 2 3 | 11 2.1|
Mixed Cell Focus | X | 1 |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 1 1 2 1 2 | 27 2.0|
Hepatocyte, Atrophy, Multifocal | 3 2 2 2 | 5 2.4|
Hepatocyte, Cytoplasmic Alteration | | 1 3.0|
Hepatocyte, Hyperplasia, Nodular | 3 3 | 2 3.0|
Hepatocyte, Necrosis, Multifocal | 1 | 2 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 4 2 | 6 2.8|
Kupffer Cell, Hyperplasia | 2 | 1 2.0|
Kupffer Cell, Pigmentation | | 4 2.8|
Portal, Fibrosis | 1 2 1 2 2 | 13 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 10 |
Fat, Mineralization | 3 4 | 4 3.3|
Fat, Necrosis, Focal | 3 4 4 4 | 9 3.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 2 | 5 1.6|
Cyst | | 1 |
Cytoplasmic Alteration | 2 | 1 2.0|
Hyperplasia | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Palate, Inflammation, Suppurative | | 1 3.0|
Palate, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectopic Tissue | 2 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 4| 3| 3| 7| 3| 3| 3| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 1| 3| 3| |
| 4| 2| 6| 5| 5| 7| 5| 5| 5| 5| 6| 1| 5| 5| 5| 5| 5| 5| 5| 4| 2| 4| 1| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Forestomach, Diverticulum | X | 1 |
Forestomach, Edema | | 1 3.0|
Forestomach, Inflammation, Chronic | | |
Active | | 1 3.0|
Forestomach, Ulcer | 3 4 | 5 3.2|
Forestomach, Mucosa, Dysplasia | 3 | 1 3.0|
Forestomach, Mucosa, Hyperplasia | 3 | 5 2.6|
Glandular, Dysplasia | 2 | 1 2.0|
Glandular, Edema | | 1 3.0|
Glandular, Erosion | 3 | 3 2.7|
Glandular, Mineralization | 2 3 2 | 5 2.2|
Glandular, Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | + + | 3 |
Inflammation, Suppurative | 2 | 1 2.0|
Epithelium, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Tooth | + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myocardium, Fibrosis | 3 3 2 2 2 3 2 2| 19 2.3|
Myocardium, Inflammation, Chronic | 1 2 2 1 2| 8 2.0|
Myocardium, Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Infiltration Cellular, Eosinophil | | 1 2.0|
Inflammation, Chronic | | 2 2.5|
Cortex, Congestion | 4 | 1 4.0|
Cortex, Cyst | X | 2 |
Cortex, Hyperplasia | 4 2 2 2 2| 5 2.4|
Cortex, Necrosis | | 1 3.0|
Cortex, Pigmentation | | 1 3.0|
Cortex, Vacuolization Cytoplasmic | 4 1 2 2 2 2 | 9 2.1|
Medulla, Hyperplasia, Focal | 2 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 4| 3| 3| 7| 3| 3| 3| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 1| 3| 3| |
| 4| 2| 6| 5| 5| 7| 5| 5| 5| 5| 6| 1| 5| 5| 5| 5| 5| 5| 5| 4| 2| 4| 1| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 1 3 | 2 2.0|
Pars Distalis, Cyst | X X X X X X X X | 17 |
Pars Distalis, Hyperplasia | 2 | 4 2.0|
Pars Intermedia, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 3.0|
Ultimobranchial Cyst | X X | 2 |
C-Cell, Hyperplasia | 2 2 2 1 3 3 | 15 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + + + M + + + + + + + + + + + + + + + + M + +| 44 |
Ectasia | 3 4 | 4 3.5|
Hyperplasia | 2 | 3 3.3|
Inflammation, Suppurative | 2 2 3 | 8 2.3|
Metaplasia, Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 6 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 3 | 2 3.0|
Hydrometra | 2 3 | 3 2.3|
Inflammation, Suppurative | | 2 2.0|
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Vagina | + | 4 |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 3 2.7|
Hyperplasia, Reticulum Cell | 3 3 3 2 4 | 8 2.6|
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Hyperplasia, Lymphoid | 3 | 1 3.0|
Axillary, Inflammation, Suppurative | 3 | 1 3.0|
Axillary, Lymphatic, Ectasia | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 4| 3| 3| 7| 3| 3| 3| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 1| 3| 3| |
| 4| 2| 6| 5| 5| 7| 5| 5| 5| 5| 6| 1| 5| 5| 5| 5| 5| 5| 5| 4| 2| 4| 1| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Bronchial, Hemorrhage | 3 | 2 2.5|
Bronchial, Infiltration Cellular, | | |
Mast Cell | | 1 3.0|
Lymphatic, Mandibular, Ectasia | | 1 2.0|
Mandibular, Hyperplasia, Plasma Cell | 3 3 | 4 2.8|
Mediastinal, Erythrophagocytosis | 3 | 3 3.0|
Mediastinal, Hemorrhage | 3 3 3 | 5 2.8|
Mediastinal, Hyperplasia, Plasma Cell| 3 | 1 3.0|
Mediastinal, Infiltration Cellular, | | |
Mast Cell | | 1 3.0|
Mediastinal, Pigmentation | 3 3 3| 10 2.8|
Mesenteric, Atrophy | 4 3 3 | 3 3.3|
Mesenteric, Erythrophagocytosis | 4 | 1 4.0|
Mesenteric, Hemorrhage | 2 | 2 2.5|
Mesenteric, Hyperplasia, Histiocytic | 2 | 1 2.0|
Mesenteric, Infiltration Cellular, | | |
Mast Cell | | 2 3.0|
Mesenteric, Pigmentation | 3 | 1 3.0|
Pancreatic, Hyperplasia, Histiocytic | | 1 3.0|
Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 4.0|
Erythrophagocytosis | 3 | 1 3.0|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | |
Granulocytic | 3 | 3 3.0|
Hematopoietic Cell Proliferation | | |
Erythrocytic | 3 2 2 3 3 | 7 2.6|
Pigmentation, Hemosiderin | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | M M + M + + + + + + + + + + + M + + M + + + + M +| 39 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 4 2 3 2 3 2 3 2 2 3 3 2 2 2 2 1 4 2 3 2 1| 41 2.3|
Hyperplasia, Lobular | 2 3 | 2 2.5|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 4 | 2 3.0|
Hyperkeratosis | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 4| 3| 3| 7| 3| 3| 3| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 1| 3| 3| |
| 4| 2| 6| 5| 5| 7| 5| 5| 5| 5| 6| 1| 5| 5| 5| 5| 5| 5| 5| 4| 2| 4| 1| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 2 2.0|
Degeneration, Multiple | 3 3 3 | 7 2.7|
Hydrocephalus | | 1 2.0|
Cerebrum, Degeneration | 1 | 2 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenomatosis | 1 3 | 3 2.0|
Edema, Diffuse | | 1 3.0|
Fibrosis | | 1 2.0|
Foreign Body | | 1 4.0|
Hemorrhage | 3 | 3 3.0|
Infiltration Cellular, Histiocyte | 2 1 2 1 2 1 1 1 2 1 1 1 1 1 1| 35 1.4|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Fungus | 2 3 | 2 2.5|
Lumen, Inflammation, Suppurative | 3 3 1 | 3 2.3|
Mucosa, Metaplasia, Squamous | X 2 | 2 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 3 2.0|
Submucosa, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + M | 2 |
Cataract | 3 | 2 3.5|
Retina, Atrophy | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 4| 3| 3| 7| 3| 3| 3| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 1| 3| 3| |
| 4| 2| 6| 5| 5| 7| 5| 5| 5| 5| 6| 1| 5| 5| 5| 5| 5| 5| 5| 4| 2| 4| 1| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 4 1.8|
Inflammation, Suppurative | | 1 2.0|
Nephropathy | 3 1 1 1 1 2 1 2 1 2 1 2 2 1 2 1 1 1| 34 1.3|
Pelvis, Mineralization | 2 1 2 2 1 | 13 1.5|
Renal Tubule, Mineralization | | 4 1.3|
Renal Tubule, Necrosis | | 1 4.0|
Renal Tubule, Pigmentation | 2 | 8 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 3| 5| 5| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 8| 5| 6| 4| 2| 8| 2| 2| 2| 3| 8| 2| 2| 3| 3| 7| 3| 3| 3| 3| 8| 7| 3| 3| 2|
| 3| 7| 7| 2| 9| 2| 9| 9| 9| 0| 6| 7| 7| 0| 0| 2| 0| 0| 0| 0| 7| 7| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
8.0 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cecum, Parasite Metazoan | |
Colon, Parasite Metazoan | 1 2 2 |
Colon, Serosa, Cyst | |
Rectum, Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
Jejunum, Developmental Malformation | X |
Jejunum, Hemorrhage | |
Jejunum, Hyperplasia, Re Cell | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X |
Developmental Malformation | X X |
Inflammation, Chronic | 2 1 2 2 2 |
Inflammation, Granulomatous | 2 2 3 3 1 1 1 |
Mixed Cell Focus | |
Bile Duct, Hyperplasia | 2 3 2 2 2 3 4|
Capsule, Fibrosis | 2 |
Hepatocyte, Atrophy, Multifocal | 3 3 3 3 2 2|
Hepatocyte, Hyperplasia, Nodular | |
Hepatocyte, Necrosis, Multifocal | 1 |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
Hepatocyte, Centrilobular, Necrosis | 2 |
Kupffer Cell, Pigmentation | 4 3|
Portal, Fibrosis | 2 2 |
__________________________________________________________________________|
Mesentery | + + + +|
Ectopic Tissue | |
Fat, Fibrosis | 3 |
Fat, Mineralization | 3 3 3|
Fat, Necrosis, Focal | 3 4 3 4|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 2 1 3 3 1|
__________________________________________________________________________|
Pharynx | + |
Palate, Inflammation, Suppurative | |
Palate, Necrosis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + M + +|
Ectopic Tissue | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Inflammation, | |
Suppurative | 2 |
Forestomach, Ulcer | 3 |
Forestomach, Mucosa, Dysplasia | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 3| 5| 5| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 8| 5| 6| 4| 2| 8| 2| 2| 2| 3| 8| 2| 2| 3| 3| 7| 3| 3| 3| 3| 8| 7| 3| 3| 2|
| 3| 7| 7| 2| 9| 2| 9| 9| 9| 0| 6| 7| 7| 0| 0| 2| 0| 0| 0| 0| 7| 7| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
8.0 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Forestomach, Mucosa, Hyperplasia | 2 2 |
Glandular, Erosion | 3 4 |
Glandular, Mineralization | 2 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Fibrosis | 2 2 2 3 2 3 2 |
Myocardium, Inflammation, Chronic | 1 1 |
Myocardium, Pigmentation | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 3 |
Cortex, Congestion | 3 |
Cortex, Cytoplasmic Alteration, | |
Diffuse | 4 |
Cortex, Hematocyst | |
Cortex, Hyperplasia | 3 2 |
Cortex, Necrosis | 2 |
Cortex, Vacuolization Cytoplasmic | 2 2 2 2 3 3 |
Extra Adrenal Tissue, Developmental | |
Malformation | |
Medulla, Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + M + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 4 |
Pars Distalis, Cyst | X X X X X X X X|
Pars Distalis, Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + M + + + + + + + + M M + + + + M M + + + + + +|
Dysplasia | |
Ectasia | 3 3 |
Hyperplasia | 4 3 |
Inflammation, Chronic | |
Inflammation, Suppurative | 2 2 4 3 |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 3| 5| 5| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 8| 5| 6| 4| 2| 8| 2| 2| 2| 3| 8| 2| 2| 3| 3| 7| 3| 3| 3| 3| 8| 7| 3| 3| 2|
| 3| 7| 7| 2| 9| 2| 9| 9| 9| 0| 6| 7| 7| 0| 0| 2| 0| 0| 0| 0| 7| 7| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
8.0 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 4 4 |
Cyst | X |
Hydrometra | 2 2 |
Hyperplasia, Cystic | |
Hyperplasia, Glandular | |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 2 |
Prolapse | |
Endometrium, Dysplasia | 2 |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Vagina | + + + + M M M|
Abscess | 3 |
Cyst | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 |
Hyperplasia, Reticulum Cell | 4 1 |
Myelofibrosis | 2 3|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Plasma Cell | |
Lymphatic, Mandibular, Ectasia | 3 |
Mandibular, Hyperplasia, Histiocytic | 3 |
Mandibular, Hyperplasia, Plasma Cell | 3 3 2 3 |
Mandibular, Infiltration Cellular, | |
Mast Cell | 2 |
Mediastinal, Erythrophagocytosis | 2 |
Mediastinal, Hemorrhage | 3 2 3 2 2 |
Mediastinal, Hyperplasia, Histiocytic| 3 |
Mediastinal, Pigmentation | 3 2 3 3 3 |
Mesenteric, Atrophy | 3 3 3 |
Mesenteric, Hemorrhage | 4 |
Mesenteric, Hyperplasia, Lymphoid | |
Mesenteric, Infiltration Cellular, | |
Mast Cell | |
Mesenteric, Lymphatic, Ectasia | 3 |
Pancreatic, Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2|
Hematopoietic Cell Proliferation | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 3| 5| 5| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 8| 5| 6| 4| 2| 8| 2| 2| 2| 3| 8| 2| 2| 3| 3| 7| 3| 3| 3| 3| 8| 7| 3| 3| 2|
| 3| 7| 7| 2| 9| 2| 9| 9| 9| 0| 6| 7| 7| 0| 0| 2| 0| 0| 0| 0| 7| 7| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
8.0 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Granulocytic | 2 |
Hematopoietic Cell Proliferation | |
Erythrocytic | 2 2 2 2 2 4 |
Hemorrhage | 4 |
Necrosis | 4 4 |
Pigmentation, Hemosiderin | 4 2 3 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + M + + + M + M + + + + + M M M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia, Cystic | 2 2 2 2 4 3 2 2 2 1 3 2 3 2 |
Hyperplasia, Lobular | 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Inflammation, Chronic | 2 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 2 3 |
Degeneration, Multiple | 3 3 |
Cerebrum, Degeneration | 2 1 |
Thalamus, Degeneration | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | 1 |
Infiltration Cellular, Histiocyte | 1 2 2 1 3 2 2 3 3 2 2 2 2 1 2 3 2 2 2 2 3 2|
Inflammation, Suppurative | 1 |
Mineralization | 1 |
__________________________________________________________________________|
Nose | M + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Foreign Body | 3 2 |
Lumen, Fungus | 3 2 |
Lumen, Inflammation, Suppurative | 3 2 2 |
Nasopharyngeal Duct, Inflammation, | |
Suppurative | |
Submucosa, Inflammation, Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 3| 5| 5| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 8| 5| 6| 4| 2| 8| 2| 2| 2| 3| 8| 2| 2| 3| 3| 7| 3| 3| 3| 3| 8| 7| 3| 3| 2|
| 3| 7| 7| 2| 9| 2| 9| 9| 9| 0| 6| 7| 7| 0| 0| 2| 0| 0| 0| 0| 7| 7| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
8.0 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + M |
Cataract | 4 |
Retinal Detachment | 3 |
Retina, Atrophy | 3 |
__________________________________________________________________________|
Harderian Gland | + |
Hemorrhage | 3 |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | 2 |
Nephropathy | 2 1 1 2 1 1 1 1 1 3 1 1 1 1 2 1 1 |
Pelvis, Mineralization | 2 1 3 1 1 1 1 1 |
Pelvis, Epithelium, Hyperplasia | |
Renal Tubule, Mineralization | |
Renal Tubule, Pigmentation | 2 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 7| 3| 3| 2| 0| 3| 7| 2| 3| |
| 1| 0| 0| 0| 0| 6| 0| 0| 0| 0| 1| 2| 0| 0| 0| 1| 7| 0| 0| 1| 9| 1| 8| 1| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
8.0 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cecum, Parasite Metazoan | 2 | 1 2.0|
Colon, Parasite Metazoan | 2 2 2 2 2 | 8 1.9|
Colon, Serosa, Cyst | X | 1 |
Rectum, Parasite Metazoan | 2 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Jejunum, Developmental Malformation | | 1 |
Jejunum, Hemorrhage | 2 | 1 2.0|
Jejunum, Hyperplasia, Re Cell | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | X X X X X X X | 24 |
Clear Cell Focus | | 2 |
Developmental Malformation | | 2 |
Inflammation, Chronic | 2 | 6 1.8|
Inflammation, Granulomatous | 2 1 2 2 1 1 | 13 1.7|
Mixed Cell Focus | X | 1 |
Bile Duct, Hyperplasia | 2 1 2 2 2 2 2 2 2 2| 17 2.2|
Capsule, Fibrosis | | 1 2.0|
Hepatocyte, Atrophy, Multifocal | 2 2 3 2 3 | 11 2.5|
Hepatocyte, Hyperplasia, Nodular | 2 3 2 | 3 2.3|
Hepatocyte, Necrosis, Multifocal | 3 | 2 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 3 2 2 | 5 2.4|
Hepatocyte, Centrilobular, Necrosis | | 1 2.0|
Kupffer Cell, Pigmentation | | 2 3.5|
Portal, Fibrosis | 2 | 3 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 7 |
Ectopic Tissue | X | 1 |
Fat, Fibrosis | | 1 3.0|
Fat, Mineralization | | 3 3.0|
Fat, Necrosis, Focal | 4 3 | 6 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 4 2 1 2 2 2 1| 15 2.1|
__________________________________________________________________________|____________|
Pharynx | + | 2 |
Palate, Inflammation, Suppurative | 4 | 1 4.0|
Palate, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectopic Tissue | X| 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 7| 3| 3| 2| 0| 3| 7| 2| 3| |
| 1| 0| 0| 0| 0| 6| 0| 0| 0| 0| 1| 2| 0| 0| 0| 1| 7| 0| 0| 1| 9| 1| 8| 1| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
8.0 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Forestomach, Inflammation, | | |
Suppurative | | 1 2.0|
Forestomach, Ulcer | 4 4 | 3 3.7|
Forestomach, Mucosa, Dysplasia | 3 1 | 2 2.0|
Forestomach, Mucosa, Hyperplasia | 3 2 2 2 | 6 2.2|
Glandular, Erosion | | 2 3.5|
Glandular, Mineralization | 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myocardium, Fibrosis | 2 2| 9 2.2|
Myocardium, Inflammation, Chronic | 1 | 3 1.0|
Myocardium, Pigmentation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | | 1 3.0|
Cortex, Congestion | | 1 3.0|
Cortex, Cytoplasmic Alteration, | | |
Diffuse | | 1 4.0|
Cortex, Hematocyst | X | 1 |
Cortex, Hyperplasia | 3 3 2 3 3 | 7 2.7|
Cortex, Necrosis | | 1 2.0|
Cortex, Vacuolization Cytoplasmic | 2 2 2 3 3 2| 12 2.3|
Extra Adrenal Tissue, Developmental | | |
Malformation | X | 1 |
Medulla, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + M| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 4 2 2 | 6 2.7|
Pars Distalis, Cyst | X X X X X X X X | 16 |
Pars Distalis, Hyperplasia | 1 3 | 6 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 1 2 2 3 3 | 10 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 7| 3| 3| 2| 0| 3| 7| 2| 3| |
| 1| 0| 0| 0| 0| 6| 0| 0| 0| 0| 1| 2| 0| 0| 0| 1| 7| 0| 0| 1| 9| 1| 8| 1| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
8.0 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + + + + M + + + + + + M + + + + + + + + + + +| 41 |
Dysplasia | 3 | 1 3.0|
Ectasia | 2| 3 2.7|
Hyperplasia | 3 4 2 | 5 3.2|
Inflammation, Chronic | 3| 1 3.0|
Inflammation, Suppurative | 3 4 4 | 7 3.1|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X | 6 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 4 3 3 | 6 3.5|
Cyst | | 1 |
Hydrometra | 2 | 3 2.0|
Hyperplasia, Cystic | 2 3 | 2 2.5|
Hyperplasia, Glandular | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
Prolapse | X | 1 |
Endometrium, Dysplasia | | 1 2.0|
Mucosa, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Vagina | + + + | 7 |
Abscess | | 1 3.0|
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 3 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 2.5|
Hyperplasia, Reticulum Cell | 3 4 2 | 5 2.8|
Myelofibrosis | 2 2 2 | 5 2.2|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hyperplasia, Plasma Cell | 2 | 1 2.0|
Lymphatic, Mandibular, Ectasia | 2 | 2 2.5|
Mandibular, Hyperplasia, Histiocytic | | 1 3.0|
Mandibular, Hyperplasia, Plasma Cell | 3 3 2 | 7 2.7|
Mandibular, Infiltration Cellular, | | |
Mast Cell | | 1 2.0|
Mediastinal, Erythrophagocytosis | | 1 2.0|
Mediastinal, Hemorrhage | 3 | 6 2.5|
Mediastinal, Hyperplasia, Histiocytic| | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 7| 3| 3| 2| 0| 3| 7| 2| 3| |
| 1| 0| 0| 0| 0| 6| 0| 0| 0| 0| 1| 2| 0| 0| 0| 1| 7| 0| 0| 1| 9| 1| 8| 1| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
8.0 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Pigmentation | 3 3 3 3 3 | 10 2.9|
Mesenteric, Atrophy | 3 3 | 5 3.0|
Mesenteric, Hemorrhage | 2 | 2 3.0|
Mesenteric, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mesenteric, Infiltration Cellular, | | |
Mast Cell | 2 | 1 2.0|
Mesenteric, Lymphatic, Ectasia | 4 | 2 3.5|
Pancreatic, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | |
Granulocytic | 3 | 2 2.5|
Hematopoietic Cell Proliferation | | |
Erythrocytic | 2 2 2 | 9 2.2|
Hemorrhage | | 1 4.0|
Necrosis | | 2 4.0|
Pigmentation, Hemosiderin | 3 | 4 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + M + M + + + + M M + + + +| 39 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis | 2 | 1 2.0|
Hyperplasia, Cystic | 4 2 2 2 2 2 2 2 3 2 3 1 2 2 2 3 2 2 3 3 2| 35 2.3|
Hyperplasia, Lobular | 3 | 3 3.0|
__________________________________________________________________________|____________|
Skin | M + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
Acanthosis | 2 | 2 2.5|
Inflammation, Chronic | | 1 2.0|
Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | I + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperostosis | | 2 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 4 | 4 3.0|
Degeneration, Multiple | 2 3 3| 5 2.8|
Cerebrum, Degeneration | 2 2 | 4 1.8|
Thalamus, Degeneration | 2 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 7| 3| 3| 2| 0| 3| 7| 2| 3| |
| 1| 0| 0| 0| 0| 6| 0| 0| 0| 0| 1| 2| 0| 0| 0| 1| 7| 0| 0| 1| 9| 1| 8| 1| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
8.0 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenomatosis | 2 3 | 3 2.0|
Infiltration Cellular, Histiocyte | 3 2 2 2 2 2 2 2 2 2 2 2 3 3 1 2 2 3 2 1 3 1 1 2| 46 2.1|
Inflammation, Suppurative | 2 | 2 1.5|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Nose | M + M + + + + + + + + + + + + + + + + + + + + + +| 47 |
Lumen, Foreign Body | | 2 2.5|
Lumen, Fungus | 2 | 3 2.3|
Lumen, Inflammation, Suppurative | 2 | 4 2.3|
Nasopharyngeal Duct, Inflammation, | | |
Suppurative | 3 | 1 3.0|
Submucosa, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Cataract | | 1 4.0|
Retinal Detachment | | 1 3.0|
Retina, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X| 1 |
Inflammation, Chronic | 3 2 | 3 2.3|
Nephropathy | 3 1 2 2 2 1 1 1 1 1 1 1 1 1 1 1 1 2| 35 1.3|
Pelvis, Mineralization | 1 1 1 2 2 1 2 1 1 1| 18 1.3|
Pelvis, Epithelium, Hyperplasia | 2 | 1 2.0|
Renal Tubule, Mineralization | 1 2 1 | 3 1.3|
Renal Tubule, Pigmentation | 2 | 5 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 8| 3| 3| 9| 0| 3| 3| 3| 9| 3| 3| 3| 3| 5| 3| 3| 3| 3| 4| 0| 3| 3| 2|
| 5| 8| 4| 3| 3| 5| 9| 3| 3| 3| 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 6| 6| 3| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
4.0 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Colon, Mineralization | 3 |
Colon, Parasite Metazoan | 1 |
Rectum, Parasite Metazoan | 2 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duodenum, Ectopic Tissue | X |
Duodenum, Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X |
Developmental Malformation | X |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic | 2 2 |
Inflammation, Chronic Active | 2 |
Inflammation, Granulomatous | 2 2 2 2 1 2 |
Bile Duct, Hyperplasia | 3 2 2 2 2 2 1 2 3 2 2 2 2 1 1 1 2|
Hepatocyte, Atrophy, Multifocal | 3 2 2 2 2 2|
Hepatocyte, Cytoplasmic Alteration | 2 |
Hepatocyte, Hyperplasia, Nodular | 3 3 2 |
Hepatocyte, Necrosis, Multifocal | 3 2 3 |
Hepatocyte, Vacuolization Cytoplasmic| 2 3 |
Kupffer Cell, Pigmentation | |
Portal, Fibrosis | 2 1 2 3 1 |
Vein, Thrombosis | X |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Inflammation, Granulomatous | 3 |
Inflammation, Suppurative | 2 |
Fat, Hemorrhage | 3 |
Fat, Mineralization | 3 |
Fat, Necrosis, Focal | 3 3 2 3 3 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + M + +|
Atrophy | 1 1 3 2 |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parotid Gland, Hyperplasia, Focal | |
Parotid Gland, Vacuolization | |
Cytoplasmic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Edema | 3 |
Forestomach, Foreign Body | 3|
Forestomach, Granuloma | 4|
Forestomach, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 8| 3| 3| 9| 0| 3| 3| 3| 9| 3| 3| 3| 3| 5| 3| 3| 3| 3| 4| 0| 3| 3| 2|
| 5| 8| 4| 3| 3| 5| 9| 3| 3| 3| 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 6| 6| 3| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
4.0 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Forestomach, Ulcer | 3 2 |
Forestomach, Mucosa, Hyperplasia | 2 2 |
Glandular, Dysplasia | |
Glandular, Erosion | 2 1 |
Glandular, Inflammation, Suppurative | 2 |
Glandular, Mineralization | 1 1 2 2 1 2 2 3|
Glandular, Ulcer | |
__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
Myocardium, Fibrosis | 2 2 2 3 2 2 2 |
Myocardium, Hemorrhage | |
Myocardium, Inflammation, Chronic | 2 1 1 2 |
Myocardium, Pigmentation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic | 2 |
Cortex, Hyperplasia | |
Cortex, Vacuolization Cytoplasmic | 2 3 3 3 2|
Extra Adrenal Tissue, Developmental | |
Malformation | X X |
Medulla, Hyperplasia, Focal | 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 |
Pars Distalis, Cyst | X X X X X X X X X X X |
Pars Distalis, Hyperplasia | 3 2 2 2 |
Pars Distalis, Pigmentation | |
Pars Intermedia, Infiltration | |
Cellular | 3 |
Pars Nervosa, Hemorrhage | |
Pars Nervosa, Infiltration Cellular | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 8| 3| 3| 9| 0| 3| 3| 3| 9| 3| 3| 3| 3| 5| 3| 3| 3| 3| 4| 0| 3| 3| 2|
| 5| 8| 4| 3| 3| 5| 9| 3| 3| 3| 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 6| 6| 3| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
4.0 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + M + + M + + + + + + + + + M + + + +|
Ectasia | 3 2 |
Hyperplasia | 1 |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 2 2 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4|
Atrophy | |
Cyst | X X X X |
Hydrometra | |
Hyperplasia, Cystic | 2 |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Vagina | + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia | 3 |
Hyperplasia, Reticulum Cell | 4 3 2 4 2 |
Myelofibrosis | 4 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Hyperplasia, Lymphoid | 2 |
Mandibular, Hyperplasia, Plasma Cell | 3 2 |
Mediastinal, Hemorrhage | 2 2 2 |
Mediastinal, Pigmentation | 3 3 3 3 3 |
Mesenteric, Atrophy | 3 |
Mesenteric, Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Fibrosis | 3 2 |
Hematopoietic Cell Proliferation | |
Erythrocytic | 4 3 2 3 |
Necrosis | 3 |
Pigmentation, Hemosiderin | 3 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + M + + + + M M + M + + M + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 1 2 2 2 3 2 2 3 2 2 2 2 2 2 3 1 2 3 2 2 3 2 2|
Hyperplasia, Lobular | 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 8| 3| 3| 9| 0| 3| 3| 3| 9| 3| 3| 3| 3| 5| 3| 3| 3| 3| 4| 0| 3| 3| 2|
| 5| 8| 4| 3| 3| 5| 9| 3| 3| 3| 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 6| 6| 3| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
4.0 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + M + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Cyst Epithelial Inclusion | X |
Exudate | 1 |
Hyperkeratosis | |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Hemorrhage | |
Hyperostosis | |
Hyperplasia | |
Necrosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Degeneration, Multiple | 2 3 2|
Hydrocephalus | |
Cerebrum, Degeneration | 1 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | 1 |
Infiltration Cellular, Histiocyte | 2 1 2 2 2 2 2 2 2 2 3 3 2 2 1 1 2 1 3 2 2 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Foreign Body | |
Lumen, Fungus | |
Lumen, Inflammation, Suppurative | 2 2 |
Mucosa, Metaplasia, Squamous | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Submucosa, Inflammation, Chronic | 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 |
Cataract | 3 2 3 3 3 3 2 3 3 3 3 2 3 3 3 2 3 3 3|
Hemorrhage | 3 4 |
Cornea, Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 8| 3| 3| 9| 0| 3| 3| 3| 9| 3| 3| 3| 3| 5| 3| 3| 3| 3| 4| 0| 3| 3| 2|
| 5| 8| 4| 3| 3| 5| 9| 3| 3| 3| 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 6| 6| 3| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
4.0 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Cornea, Mineralization | 1 |
Retina, Atrophy | 3 3 3 3 3 3 3 3 3 4 3 3 3 3 3 3 3 3 3|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 |
Inflammation, Chronic | 2 |
Nephropathy | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 3 1|
Pelvis, Mineralization | 1 1 1 2 1 2 1 1 1 1 2 |
Pelvis, Epithelium, Hyperplasia | 2 |
Renal Tubule, Mineralization | 1 1 1 2 1 |
Renal Tubule, Pigmentation | 2 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 0| 5| 6| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 5| 0| 3| 3| 3| 5| 1| 0| 3| 3| 4| 0| 3| 3| 3| 9| 9| 5| 0| 3| 1| 0| 3| 3| 2| |
| 5| 8| 3| 3| 3| 6| 8| 9| 3| 3| 5| 9| 3| 3| 3| 8| 6| 6| 1| 3| 9| 4| 3| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
4.0 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Colon, Mineralization | | 1 3.0|
Colon, Parasite Metazoan | | 1 1.0|
Rectum, Parasite Metazoan | 2 | 3 2.0|
__________________________________________________________________________|____________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Duodenum, Ectopic Tissue | | 1 |
Duodenum, Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X | 27 |
Clear Cell Focus | X X X | 6 |
Developmental Malformation | X | 2 |
Hematopoietic Cell Proliferation | | 1 2.0|
Inflammation, Chronic | 1 1 2 2 2 | 7 1.7|
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Granulomatous | 2 1 2 2 | 10 1.8|
Bile Duct, Hyperplasia | 2 2 2 3 1 3 3 3 2 3 1 2| 29 2.0|
Hepatocyte, Atrophy, Multifocal | 3 2 3 3 3 3| 12 2.5|
Hepatocyte, Cytoplasmic Alteration | | 1 2.0|
Hepatocyte, Hyperplasia, Nodular | 2 3| 5 2.6|
Hepatocyte, Necrosis, Multifocal | | 3 2.7|
Hepatocyte, Vacuolization Cytoplasmic| 3 4 2 3 3 | 7 2.9|
Kupffer Cell, Pigmentation | 3 | 1 3.0|
Portal, Fibrosis | 1 1 2 2 3 1 2 1 | 13 1.7|
Vein, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + + | 12 |
Inflammation, Granulomatous | 3 | 2 3.0|
Inflammation, Suppurative | | 1 2.0|
Fat, Hemorrhage | | 1 3.0|
Fat, Mineralization | | 1 3.0|
Fat, Necrosis, Focal | 4 4 4 3 4 | 12 3.2|
__________________________________________________________________________|____________|
Pancreas | A + + + + + + + + + + + + + + + + M + + + + + + +| 47 |
Atrophy | 2 2 | 6 1.8|
Hyperplasia | 1 | 3 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parotid Gland, Hyperplasia, Focal | 2 | 1 2.0|
Parotid Gland, Vacuolization | | |
Cytoplasmic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 0| 5| 6| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 5| 0| 3| 3| 3| 5| 1| 0| 3| 3| 4| 0| 3| 3| 3| 9| 9| 5| 0| 3| 1| 0| 3| 3| 2| |
| 5| 8| 3| 3| 3| 6| 8| 9| 3| 3| 5| 9| 3| 3| 3| 8| 6| 6| 1| 3| 9| 4| 3| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
4.0 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Forestomach, Edema | 3 4 2 | 4 3.0|
Forestomach, Foreign Body | | 1 3.0|
Forestomach, Granuloma | | 1 4.0|
Forestomach, Inflammation, | | |
Suppurative | 2 | 1 2.0|
Forestomach, Ulcer | 4 3 4 4 | 6 3.3|
Forestomach, Mucosa, Hyperplasia | 3 3 1 3 | 6 2.3|
Glandular, Dysplasia | 1 | 1 1.0|
Glandular, Erosion | 2 1 | 4 1.5|
Glandular, Inflammation, Suppurative | | 1 2.0|
Glandular, Mineralization | 3 1 2| 11 1.8|
Glandular, Ulcer | 3 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Tongue | | 1 |
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | X | 1 |
Myocardium, Fibrosis | 3 2 2 2 3 2 1 2 2 2 2 | 18 2.1|
Myocardium, Hemorrhage | 1 | 1 1.0|
Myocardium, Inflammation, Chronic | 2 2 2 1 1 | 9 1.6|
Myocardium, Pigmentation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Cortex, Hyperplasia | 3 | 1 3.0|
Cortex, Vacuolization Cytoplasmic | 3 1 2 1 1 2 2 2 2 1 2 3| 17 2.1|
Extra Adrenal Tissue, Developmental | | |
Malformation | | 2 |
Medulla, Hyperplasia, Focal | | 2 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | A + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + M + +| 47 |
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 2 2 | 4 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 0| 5| 6| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 5| 0| 3| 3| 3| 5| 1| 0| 3| 3| 4| 0| 3| 3| 3| 9| 9| 5| 0| 3| 1| 0| 3| 3| 2| |
| 5| 8| 3| 3| 3| 6| 8| 9| 3| 3| 5| 9| 3| 3| 3| 8| 6| 6| 1| 3| 9| 4| 3| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
4.0 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Cyst | X X X X X X X X| 19 |
Pars Distalis, Hyperplasia | 2 | 5 2.2|
Pars Distalis, Pigmentation | 3 | 1 3.0|
Pars Intermedia, Infiltration | | |
Cellular | | 1 3.0|
Pars Nervosa, Hemorrhage | 2 | 1 2.0|
Pars Nervosa, Infiltration Cellular | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 1 2 2 1 2 | 9 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + + + + + + + + + + + + + M + + + M + + + + +| 43 |
Ectasia | 3 2 3 | 5 2.6|
Hyperplasia | 2 4 | 3 2.3|
Inflammation, Chronic | 4 | 2 3.0|
Inflammation, Suppurative | 4 4 | 6 2.7|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 4 4 4 | 4 4.0|
Atrophy | 3 | 1 3.0|
Cyst | X | 5 |
Hydrometra | 2 | 1 2.0|
Hyperplasia, Cystic | 2 2 2 2 2| 6 2.0|
Mucosa, Hyperplasia | 3| 1 3.0|
__________________________________________________________________________|____________|
Vagina | + + | 8 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 3.0|
Hyperplasia | | 1 3.0|
Hyperplasia, Reticulum Cell | | 5 3.0|
Myelofibrosis | | 2 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mandibular, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 0| 5| 6| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 5| 0| 3| 3| 3| 5| 1| 0| 3| 3| 4| 0| 3| 3| 3| 9| 9| 5| 0| 3| 1| 0| 3| 3| 2| |
| 5| 8| 3| 3| 3| 6| 8| 9| 3| 3| 5| 9| 3| 3| 3| 8| 6| 6| 1| 3| 9| 4| 3| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
4.0 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mandibular, Hyperplasia, Plasma Cell | 3 3 2 | 5 2.6|
Mediastinal, Hemorrhage | 3 2 | 5 2.2|
Mediastinal, Pigmentation | 3 3 3 | 8 3.0|
Mesenteric, Atrophy | 3 3 3 | 4 3.0|
Mesenteric, Hemorrhage | 4 2 | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Developmental Malformation | | 1 |
Fibrosis | 3 3 2 | 5 2.6|
Hematopoietic Cell Proliferation | | |
Erythrocytic | 3 2 3 | 7 2.9|
Necrosis | | 1 3.0|
Pigmentation, Hemosiderin | 3 3 | 5 3.0|
__________________________________________________________________________|____________|
Thymus | M M + + + + + + + + + + + + + + M M M + + + + + +| 39 |
Atrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2| 43 2.1|
Hyperplasia, Lobular | 3 3 | 5 3.0|
__________________________________________________________________________|____________|
Skin | I + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Acanthosis | 3 | 1 3.0|
Cyst Epithelial Inclusion | | 1 |
Exudate | | 1 1.0|
Hyperkeratosis | 2 | 1 2.0|
Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Developmental Malformation | X | 1 |
Hemorrhage | 4 | 1 4.0|
Hyperostosis | 3 | 1 3.0|
Hyperplasia | 4 | 1 4.0|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 3 3 3 3 | 5 3.0|
Degeneration, Multiple | 3 3 1 2 | 7 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 0| 5| 6| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 5| 0| 3| 3| 3| 5| 1| 0| 3| 3| 4| 0| 3| 3| 3| 9| 9| 5| 0| 3| 1| 0| 3| 3| 2| |
| 5| 8| 3| 3| 3| 6| 8| 9| 3| 3| 5| 9| 3| 3| 3| 8| 6| 6| 1| 3| 9| 4| 3| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
4.0 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Hydrocephalus | 2 | 1 2.0|
Cerebrum, Degeneration | 1 | 2 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + M + + + + + M + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenomatosis | | 1 1.0|
Infiltration Cellular, Histiocyte | 2 1 1 2 1 1 2 1 2 1 2 1 2 2 1 2 | 39 1.8|
__________________________________________________________________________|____________|
Nose | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lumen, Foreign Body | 2 | 1 2.0|
Lumen, Fungus | 2 | 1 2.0|
Lumen, Inflammation, Suppurative | 2 2 | 4 2.0|
Mucosa, Metaplasia, Squamous | 3 | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
Submucosa, Inflammation, Chronic | | 3 2.0|
__________________________________________________________________________|____________|
Trachea | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + M + + M +| 23 |
Angiectasis | | 2 2.5|
Cataract | 3 3 2 2| 23 2.7|
Hemorrhage | | 2 3.5|
Cornea, Inflammation, Chronic | | 1 1.0|
Cornea, Mineralization | | 1 1.0|
Retina, Atrophy | 3 3 3 3| 23 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 1 3.0|
Inflammation, Chronic | 1 | 2 1.5|
Nephropathy | 1 1 1 1 1 1 2 2 2 1 1 2 1 2 1 1 1 1 1| 38 1.2|
Pelvis, Mineralization | 2 2 2 1 2 2 3 2 | 19 1.6|
Pelvis, Epithelium, Hyperplasia | | 1 2.0|
Renal Tubule, Mineralization | 1 2 1 2 1 2 1| 12 1.3|
Renal Tubule, Pigmentation | 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mucosa, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 2| 9| 1| 3| 3| 3| 3| 3| 3| 3| 8| 5| 5| 3| 3| 5| 3| 3| 3| 3|
| 6| 4| 4| 4| 4| 2| 5| 9| 4| 4| 4| 4| 4| 4| 4| 7| 3| 7| 4| 4| 1| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cecum, Parasite Metazoan | 1 1 |
Colon, Mineralization | |
Colon, Parasite Metazoan | 1 2 2 2 2 |
Rectum, Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
Jejunum, Inflammation, Chronic | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 2 2 |
Basophilic Focus | X X X |
Clear Cell Focus | |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | 2 2 2 |
Bile Duct, Hyperplasia | 2 1 3 2 4 3 3 2 2 3 3 1 2 3 3 2 2 3 3 2 4 2 1 4|
Hepatocyte, Atrophy, Multifocal | 2 2 2 3|
Hepatocyte, Hyperplasia, Nodular | 3 |
Hepatocyte, Necrosis, Multifocal | 2 2 |
Hepatocyte, Vacuolization Cytoplasmic| 3 2 2 1 |
Hepatocyte, Centrilobular, Necrosis | 2 |
Portal, Fibrosis | 2 2 2 2 2 2 2 1 2 2 1 2|
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Chronic Active | |
Pigmentation | 3 |
Fat, Necrosis, Focal | 3 4 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 1 4 2 2 2 1 3|
Cyst | X |
Hyperplasia | 2 2 3 3 2 |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Pharynx | + |
Palate, Hyperplasia | 3 |
Palate, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Inflammation, Chronic | |
Forestomach, Inflammation, Chronic | |
Active | 3 |
Forestomach, Mineralization | 4 |
Forestomach, Ulcer | |
Forestomach, Mucosa, Hyperplasia | 3 2 2 3 3|
Glandular, Cyst | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 2| 9| 1| 3| 3| 3| 3| 3| 3| 3| 8| 5| 5| 3| 3| 5| 3| 3| 3| 3|
| 6| 4| 4| 4| 4| 2| 5| 9| 4| 4| 4| 4| 4| 4| 4| 7| 3| 7| 4| 4| 1| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Glandular, Erosion | 2 3 |
Glandular, Mineralization | 2 2 |
__________________________________________________________________________|
Tooth | + |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Hypertrophy | 3 |
Inflammation, Chronic Active | 2 |
Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | X |
Artery, Mineralization | |
Myocardium, Fibrosis | 3 3 2 2 3 2 2 2 3 2 2 2 2 3 2 2|
Myocardium, Inflammation, Chronic | 3 2 2 1 1 |
Myocardium, Inflammation, Chronic | |
Active | |
Myocardium, Metaplasia, Osseous | 2 |
Myocardium, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Cortex, Cyst | |
Cortex, Fibrosis | 3 |
Cortex, Hematocyst | X X |
Cortex, Hyperplasia | 2 |
Cortex, Inflammation, Suppurative | |
Cortex, Vacuolization Cytoplasmic | |
Extra Adrenal Tissue, Developmental | |
Malformation | X|
Medulla, Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hyperplasia | 2 3 1 |
Pars Intermedia, Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2|
Follicle, Dilatation | 2 |
Follicle, Pigmentation | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 2| 9| 1| 3| 3| 3| 3| 3| 3| 3| 8| 5| 5| 3| 3| 5| 3| 3| 3| 3|
| 6| 4| 4| 4| 4| 2| 5| 9| 4| 4| 4| 4| 4| 4| 4| 7| 3| 7| 4| 4| 1| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + M + + + + + + + M + + + + + + + +|
Cyst | X |
Hyperplasia | 3 2 4 4 |
Inflammation, Chronic | 3 2 2 3 3 3 3 3 3 |
Inflammation, Suppurative | 4 4 2 2 3 3 2 3 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | 3 2 2 |
Fibrosis | |
Inflammation, Chronic | |
Inflammation, Suppurative | 3 3 2 2 2 2 2|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | 3 3 3 |
Seminiferous Tubule, Mineralization | 2 2 2 2 3 2 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 2 |
Hyperplasia, Reticulum Cell | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hemorrhage | |
Inguinal, Lymphatic, Ectasia | |
Lymphatic, Mandibular, Ectasia | |
Mandibular, Hyperplasia, Plasma Cell | 2 3 2 3 |
Mandibular, Metaplasia, Osseous | 4 |
Mediastinal, Atrophy | |
Mediastinal, Erythrophagocytosis | 3 3 |
Mediastinal, Hemorrhage | 2 2 2 3 |
Mediastinal, Hyperplasia, Plasma Cell| |
Mediastinal, Pigmentation | 2 3 |
Mediastinal, Lymphatic, Ectasia | |
Mesenteric, Atrophy | 3 3 |
Mesenteric, Hematopoietic Cell | |
Proliferation | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 2| 9| 1| 3| 3| 3| 3| 3| 3| 3| 8| 5| 5| 3| 3| 5| 3| 3| 3| 3|
| 6| 4| 4| 4| 4| 2| 5| 9| 4| 4| 4| 4| 4| 4| 4| 7| 3| 7| 4| 4| 1| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesenteric, Hyperplasia, Histiocytic | 2 |
Mesenteric, Hyperplasia, Plasma Cell | 2 |
Mesenteric, Necrosis | 2 |
Mesenteric, Lymphatic, Ectasia | |
Pancreatic, Hyperplasia, Lymphoid | |
Pancreatic, Pigmentation | 3|
Pancreatic, Lymphatic, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + M + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 2 |
Congestion | 2 |
Degeneration, Fatty | 4 |
Fibrosis | 3 2 3|
Hematopoietic Cell Proliferation | |
Granulocytic | |
Hematopoietic Cell Proliferation | |
Erythrocytic | 3 2 2 |
Hyperplasia, Histiocytic | |
Pigmentation, Hemosiderin | |
Lymphatic, Ectasia | 3 |
__________________________________________________________________________|
Thymus | + + M + + + + + + + M + + + M + + M + + + M + M M|
Cyst | X X X |
Ectopic Parathyroid Gland | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + I + + + + + M + + + + + + + + + + M + +|
Hyperplasia, Cystic | 3 2 2 1 2 3 2 |
Hyperplasia, Lobular | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X X |
Foreign Body | |
Inflammation, Chronic Active | 2 |
Inflammation, Granulomatous | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 |
Hyperostosis | 3 X |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 2| 9| 1| 3| 3| 3| 3| 3| 3| 3| 8| 5| 5| 3| 3| 5| 3| 3| 3| 3|
| 6| 4| 4| 4| 4| 2| 5| 9| 4| 4| 4| 4| 4| 4| 4| 7| 3| 7| 4| 4| 1| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Degeneration, Multiple | 4 |
Cerebrum, Degeneration | |
Thalamus, Hemorrhage | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mast Cell | |
Infiltration Cellular, Lymphocyte, | |
Polymorphonuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | 2 3 4 3 |
Edema, Diffuse | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic | 2 |
Inflammation, Granulomatous | 3 3 3 |
Inflammation, Suppurative | |
Artery, Mineralization | 2 2 |
Parenchyma, Mineralization | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Foreign Body | |
Lumen, Fungus | 3 3 |
Lumen, Inflammation, Suppurative | 3 3 |
Mucosa, Hyperplasia | |
Mucosa, Inflammation, Chronic | 3 |
Mucosa, Necrosis | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3|
Submucosa, Inflammation, Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | |
Retina, Atrophy | 2 |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 2 |
Inflammation, Chronic | 1 3 3 3 3 3 3 3 3 2 3 3 2 2 3 4|
Inflammation, Suppurative | 1 1 |
Nephropathy | 2 3 3 3 1 2 2 3 3 3 2 3 3 3 2 2 2 4 3 2 1 2 2 3 3|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 2| 9| 1| 3| 3| 3| 3| 3| 3| 3| 8| 5| 5| 3| 3| 5| 3| 3| 3| 3|
| 6| 4| 4| 4| 4| 2| 5| 9| 4| 4| 4| 4| 4| 4| 4| 7| 3| 7| 4| 4| 1| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Papilla, Necrosis | |
Pelvis, Mineralization | 1 |
Renal Tubule, Dilatation | |
Renal Tubule, Mineralization | 1 1 |
Renal Tubule, Pigmentation | 3 |
__________________________________________________________________________|
Ureter | |
Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 8| 0| 3| 3| 3| 0| 1| 3| 3| 3| 9| 1| 3| 2| 3| 1| 3| 3| 3| 3| 4| 7| 2| 3| 3| |
| 7| 5| 4| 3| 4| 6| 9| 3| 3| 3| 3| 5| 3| 8| 2| 7| 4| 4| 4| 4| 6| 4| 7| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cecum, Parasite Metazoan | 2 2 | 4 1.5|
Colon, Mineralization | 4 | 1 4.0|
Colon, Parasite Metazoan | 2 2 2 4| 9 2.1|
Rectum, Parasite Metazoan | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Jejunum, Inflammation, Chronic | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 4 2.3|
Basophilic Focus | X X X X X X X X X X X X X| 16 |
Clear Cell Focus | X X X X| 4 |
Eosinophilic Focus | X | 1 |
Hematopoietic Cell Proliferation | 2 2 | 2 2.0|
Inflammation, Chronic | 2 3 2 2 2| 8 2.1|
Bile Duct, Hyperplasia | 2 2 3 3 3 2 2 2 3 4 2 3 2 3 2 2 2 2 2 2 2 3 3| 47 2.5|
Hepatocyte, Atrophy, Multifocal | 3 2 | 6 2.3|
Hepatocyte, Hyperplasia, Nodular | | 1 3.0|
Hepatocyte, Necrosis, Multifocal | 2 | 3 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 3 2 | 7 2.3|
Hepatocyte, Centrilobular, Necrosis | 2 3 | 3 2.3|
Portal, Fibrosis | 2 2 2 2 3 2 3 2 1 2 1 2 | 24 1.9|
__________________________________________________________________________|____________|
Mesentery | + + + + | 9 |
Inflammation, Chronic Active | 3 | 1 3.0|
Pigmentation | | 1 3.0|
Fat, Necrosis, Focal | 2 | 3 3.0|
Fat, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 3 1 3 4 3 2 2| 17 2.4|
Cyst | | 1 |
Hyperplasia | 1 3 3 2 | 9 2.3|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Palate, Hyperplasia | | 1 3.0|
Palate, Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + I + + + + + + + M + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Forestomach, Inflammation, Chronic | 2 | 1 2.0|
Forestomach, Inflammation, Chronic | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 8| 0| 3| 3| 3| 0| 1| 3| 3| 3| 9| 1| 3| 2| 3| 1| 3| 3| 3| 3| 4| 7| 2| 3| 3| |
| 7| 5| 4| 3| 4| 6| 9| 3| 3| 3| 3| 5| 3| 8| 2| 7| 4| 4| 4| 4| 6| 4| 7| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Active | | 1 3.0|
Forestomach, Mineralization | 4 | 2 4.0|
Forestomach, Ulcer | 4 3 | 2 3.5|
Forestomach, Mucosa, Hyperplasia | 3 2 2 2 | 9 2.4|
Glandular, Cyst | X | 1 |
Glandular, Erosion | 4 2 | 4 2.8|
Glandular, Mineralization | 2 2 4 2 3 3 2 3 | 10 2.5|
__________________________________________________________________________|____________|
Tooth | + | 2 |
Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 4 |
Hypertrophy | 3 | 2 3.0|
Inflammation, Chronic Active | 3 | 2 2.5|
Mineralization | 4 | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | X | 2 |
Artery, Mineralization | 2 | 1 2.0|
Myocardium, Fibrosis | 3 2 1 2 3 3 2 3 3 3 2 2 2 2 2 2 2 3 2 3| 36 2.3|
Myocardium, Inflammation, Chronic | 2 2 2 1 | 9 1.8|
Myocardium, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
Myocardium, Metaplasia, Osseous | | 1 2.0|
Myocardium, Mineralization | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Cortex, Cyst | X X | 2 |
Cortex, Fibrosis | | 1 3.0|
Cortex, Hematocyst | X | 3 |
Cortex, Hyperplasia | 2 3 | 3 2.3|
Cortex, Inflammation, Suppurative | 1 | 1 1.0|
Cortex, Vacuolization Cytoplasmic | 2 2 2 | 3 2.0|
Extra Adrenal Tissue, Developmental | | |
Malformation | X X | 3 |
Medulla, Hyperplasia | 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + M M| 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 8| 0| 3| 3| 3| 0| 1| 3| 3| 3| 9| 1| 3| 2| 3| 1| 3| 3| 3| 3| 4| 7| 2| 3| 3| |
| 7| 5| 4| 3| 4| 6| 9| 3| 3| 3| 3| 5| 3| 8| 2| 7| 4| 4| 4| 4| 6| 4| 7| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 3 | 1 3.0|
Pars Distalis, Cyst | | 4 |
Pars Distalis, Hyperplasia | 1 1| 5 1.6|
Pars Intermedia, Cyst | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 2 2 2 2 2| 7 2.0|
Follicle, Dilatation | | 1 2.0|
Follicle, Pigmentation | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | | 1 |
Hyperplasia | 4 2 3 3 3 | 9 3.1|
Inflammation, Chronic | 3 2 3 3 2 3 2 | 16 2.7|
Inflammation, Suppurative | 4 4 3 4 4 2 2| 16 3.1|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Corpora Amylacea | 2 2 3| 6 2.3|
Fibrosis | 3 4 | 2 3.5|
Inflammation, Chronic | 4 | 1 4.0|
Inflammation, Suppurative | 2 2 4 3 2 2 2 3 2 2| 17 2.4|
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + +| 3 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | 2 2 | 2 2.0|
Seminiferous Tubule, Atrophy | 3 4 2 | 6 3.0|
Seminiferous Tubule, Mineralization | 2 3 2 2 3 3 2 2 3| 17 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia | 3 | 2 2.5|
Hyperplasia, Reticulum Cell | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 8| 0| 3| 3| 3| 0| 1| 3| 3| 3| 9| 1| 3| 2| 3| 1| 3| 3| 3| 3| 4| 7| 2| 3| 3| |
| 7| 5| 4| 3| 4| 6| 9| 3| 3| 3| 3| 5| 3| 8| 2| 7| 4| 4| 4| 4| 6| 4| 7| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hemorrhage | 3 | 1 3.0|
Inguinal, Lymphatic, Ectasia | 3 | 1 3.0|
Lymphatic, Mandibular, Ectasia | 2 3 3 2| 4 2.5|
Mandibular, Hyperplasia, Plasma Cell | 2 3 3 3 | 8 2.6|
Mandibular, Metaplasia, Osseous | | 1 4.0|
Mediastinal, Atrophy | 3 | 1 3.0|
Mediastinal, Erythrophagocytosis | | 2 3.0|
Mediastinal, Hemorrhage | 3 2 | 6 2.3|
Mediastinal, Hyperplasia, Plasma Cell| 3 | 1 3.0|
Mediastinal, Pigmentation | 3 | 3 2.7|
Mediastinal, Lymphatic, Ectasia | 2 | 1 2.0|
Mesenteric, Atrophy | 3 | 3 3.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation | 2 | 1 2.0|
Mesenteric, Hyperplasia, Histiocytic | | 1 2.0|
Mesenteric, Hyperplasia, Plasma Cell | | 1 2.0|
Mesenteric, Necrosis | | 1 2.0|
Mesenteric, Lymphatic, Ectasia | 2 2 | 2 2.0|
Pancreatic, Hyperplasia, Lymphoid | 2 | 1 2.0|
Pancreatic, Pigmentation | | 1 3.0|
Pancreatic, Lymphatic, Ectasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 | 4 2.8|
Congestion | | 1 2.0|
Degeneration, Fatty | | 1 4.0|
Fibrosis | 3 | 4 2.8|
Hematopoietic Cell Proliferation | | |
Granulocytic | 3 | 1 3.0|
Hematopoietic Cell Proliferation | | |
Erythrocytic | 4 2 2 2 3 2 | 9 2.4|
Hyperplasia, Histiocytic | 3 | 1 3.0|
Pigmentation, Hemosiderin | 4 3 | 2 3.5|
Lymphatic, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M + M + M + + + + + + M + + + M M M M + + M + + +| 34 |
Cyst | X X | 5 |
Ectopic Parathyroid Gland | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 8| 0| 3| 3| 3| 0| 1| 3| 3| 3| 9| 1| 3| 2| 3| 1| 3| 3| 3| 3| 4| 7| 2| 3| 3| |
| 7| 5| 4| 3| 4| 6| 9| 3| 3| 3| 3| 5| 3| 8| 2| 7| 4| 4| 4| 4| 6| 4| 7| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 46 |
Hyperplasia, Cystic | 2 1 1 4 3 3 3 3 3 | 16 2.4|
Hyperplasia, Lobular | 4 | 1 4.0|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Cyst Epithelial Inclusion | | 2 |
Foreign Body | 3 | 1 3.0|
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Granulomatous | 3 | 1 3.0|
Inflammation, Suppurative | 2 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 | 2 2.0|
Hyperostosis | | 2 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 3 | 2 3.0|
Degeneration, Multiple | 3 2 | 3 3.0|
Cerebrum, Degeneration | 2 | 1 2.0|
Thalamus, Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mast Cell | 2| 1 2.0|
Infiltration Cellular, Lymphocyte, | | |
Polymorphonuclear | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenomatosis | 2 | 5 2.8|
Edema, Diffuse | 3 | 1 3.0|
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 2 1 1 1 3 2 2 1 1 2 1 2 | 28 1.3|
Inflammation, Chronic | | 1 2.0|
Inflammation, Granulomatous | 3 | 4 3.0|
Inflammation, Suppurative | 2 3 | 2 2.5|
Artery, Mineralization | | 2 2.0|
Parenchyma, Mineralization | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 8| 0| 3| 3| 3| 0| 1| 3| 3| 3| 9| 1| 3| 2| 3| 1| 3| 3| 3| 3| 4| 7| 2| 3| 3| |
| 7| 5| 4| 3| 4| 6| 9| 3| 3| 3| 3| 5| 3| 8| 2| 7| 4| 4| 4| 4| 6| 4| 7| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Lumen, Foreign Body | 2 3 | 2 2.5|
Lumen, Fungus | 4 3 | 4 3.3|
Lumen, Inflammation, Suppurative | 2 2 2 4 2 3 | 8 2.6|
Mucosa, Hyperplasia | 2 | 1 2.0|
Mucosa, Inflammation, Chronic | | 1 3.0|
Mucosa, Necrosis | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 2 2.5|
Submucosa, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Cataract | 2 | 1 2.0|
Retina, Atrophy | 4 | 2 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | 4 | 3 2.7|
Inflammation, Chronic | 3 3 2 3 3 3 3 3 2 2 2 2 3 2 | 30 2.7|
Inflammation, Suppurative | 1 1 2 2 | 6 1.3|
Nephropathy | 2 4 3 2 3 1 3 3 3 2 2 2 3 2 2 2 3 2 3 2 2 2 3 3 2| 50 2.5|
Papilla, Necrosis | 3 | 1 3.0|
Pelvis, Mineralization | | 1 1.0|
Renal Tubule, Dilatation | 3 | 1 3.0|
Renal Tubule, Mineralization | 2 1 4 1 1 2 | 8 1.6|
Renal Tubule, Pigmentation | 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Ureter | + | 1 |
Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 6| 0| 1| 2| 2| 6| 7| 2| 2| 2| 5| 2| 2| 2| 2| 6| 7| 9| 1| 2| 6| 0| 2| 2| 2|
| 7| 0| 4| 9| 9| 2| 0| 7| 9| 9| 2| 9| 9| 9| 9| 1| 4| 5| 9| 9| 7| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
8.0 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cecum, Fibrosis | 3 |
Cecum, Mineralization | |
Cecum, Parasite Metazoan | |
Colon, Edema | |
Colon, Inflammation, Chronic Active | |
Rectum, Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duodenum, Erosion | |
Duodenum, Inflammation, Chronic | |
Duodenum, Inflammation, Suppurative | 2 |
Muscularis, Jejunum, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X X X X X|
Clear Cell Focus | X X X|
Cyst Multilocular | X X X X X |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 3 3 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 |
Inflammation, Granulomatous | 2 |
Mixed Cell Focus | X |
Bile Duct, Hyperplasia | 1 3 3 2 2 2 2 2 2 2 2 2 2 3 2 3 3 1 3 2|
Hepatocyte, Atrophy, Multifocal | 2 2 3 3 |
Hepatocyte, Hyperplasia, Nodular | 2 |
Hepatocyte, Necrosis, Multifocal | 1 |
Hepatocyte, Vacuolization Cytoplasmic| 3 3 2 3 2 3 3 2 3 2 |
Hepatocyte, Centrilobular, Necrosis | |
Portal, Fibrosis | 2 3 2 2 1 3 2 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Mineralization | |
Fat, Inflammation, Granulomatous | 4 |
Fat, Necrosis, Focal | 4 4 2 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 2 4 3 2 4 1 2|
Hyperplasia | 3 3 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + I + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Edema | |
Forestomach, Erosion | 3 |
Forestomach, Fibrosis | 3 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 6| 0| 1| 2| 2| 6| 7| 2| 2| 2| 5| 2| 2| 2| 2| 6| 7| 9| 1| 2| 6| 0| 2| 2| 2|
| 7| 0| 4| 9| 9| 2| 0| 7| 9| 9| 2| 9| 9| 9| 9| 1| 4| 5| 9| 9| 7| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
8.0 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Forestomach, Inflammation, Chronic | |
Forestomach, Inflammation, Chronic | |
Active | 3 |
Forestomach, Mineralization | |
Forestomach, Perforation | |
Forestomach, Ulcer | 4 2 |
Forestomach, Mucosa, Hyperplasia | 3 |
Glandular, Erosion | |
Glandular, Inflammation, Chronic | |
Active | |
Glandular, Mineralization | 2 2 |
Glandular, Ulcer | |
__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Inflammation, Chronic Active | 3 3 |
Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + M + + + + + + + + + +|
Thrombosis | X |
Myocardium, Fibrosis | 2 3 2 2 3 3 3 3 2 3 2 2 2 3 3 3 2 2 3|
Myocardium, Inflammation, Chronic | 3 |
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Hyperplasia | |
Cortex, Vacuolization Cytoplasmic | 2 2 1 2 2 2 2|
Extra Adrenal Tissue, Developmental | |
Malformation | X X |
Medulla, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M M + + + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | |
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia | |
Pars Distalis, Necrosis | 3 |
Pars Intermedia, Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 6| 0| 1| 2| 2| 6| 7| 2| 2| 2| 5| 2| 2| 2| 2| 6| 7| 9| 1| 2| 6| 0| 2| 2| 2|
| 7| 0| 4| 9| 9| 2| 0| 7| 9| 9| 2| 9| 9| 9| 9| 1| 4| 5| 9| 9| 7| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
8.0 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Ultimobranchial Cyst | X X |
C-Cell, Hyperplasia | 1 2 1 1 2 1 1 3|
Follicle, Dilatation | 3 3 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Ectasia | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + M M + + + + + + + M M + + + + + + + + +|
Ectasia | 2 |
Hyperplasia | 3 4 2 4 2 |
Inflammation, Chronic | 3 3 2 3 2 2 |
Inflammation, Suppurative | 3 3 4 3 3 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | |
Edema | |
Inflammation, Chronic | 2 2 |
Inflammation, Suppurative | 2 2 2 1 1 3 2 3|
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 |
Hemorrhage | 4 |
Necrosis | 4 |
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | 4 |
Seminiferous Tubule, Mineralization | 2 3 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Hyperplasia, Plasma Cell | 3 |
Bronchial, Pigmentation | |
Inguinal, Hyperplasia, Plasma Cell | 4 |
Inguinal, Lymphatic, Ectasia | 3 |
Lumbar, Lymphatic, Ectasia | 4 |
Lymphatic, Mandibular, Ectasia | 3 2 4 |
Mandibular, Hyperplasia, Plasma Cell | 3 2 3 |
Mediastinal, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 6| 0| 1| 2| 2| 6| 7| 2| 2| 2| 5| 2| 2| 2| 2| 6| 7| 9| 1| 2| 6| 0| 2| 2| 2|
| 7| 0| 4| 9| 9| 2| 0| 7| 9| 9| 2| 9| 9| 9| 9| 1| 4| 5| 9| 9| 7| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
8.0 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Erythrophagocytosis | 3 |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Pigmentation | 3 |
Mediastinal, Lymphatic, Ectasia | 3 |
Mesenteric, Atrophy | 3 3 3 |
Mesenteric, Hemorrhage | |
Mesenteric, Hyperplasia, Lymphoid | 3 |
Mesenteric, Lymphatic, Ectasia | 3|
Renal, Pigmentation | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | |
Granulocytic | 2 3 |
Hematopoietic Cell Proliferation | |
Erythrocytic | 2 2 3 |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Thymus | + M + + + + M M + + M M M M M + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 3 3 2 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + M +|
Acanthosis | |
Cyst Epithelial Inclusion | |
Exudate | |
Hyperkeratosis | |
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Multiple | 3 |
Necrosis | |
Cerebellum, Mineralization | |
Cerebrum, Degeneration | |
Cerebrum, Hemorrhage | 3 |
Cerebrum, Necrosis | 3 |
Thalamus, Degeneration | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 6| 0| 1| 2| 2| 6| 7| 2| 2| 2| 5| 2| 2| 2| 2| 6| 7| 9| 1| 2| 6| 0| 2| 2| 2|
| 7| 0| 4| 9| 9| 2| 0| 7| 9| 9| 2| 9| 9| 9| 9| 1| 4| 5| 9| 9| 7| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
8.0 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + M + + + + + + + + + +|
Adenomatosis | |
Edema, Diffuse | |
Foreign Body | 2 3 |
Hemorrhage | 3 |
Infiltration Cellular, Histiocyte | 1 2 1 1 1 1 3 2 2 2 2 1 |
Inflammation, Granulomatous | 2 3 |
__________________________________________________________________________|
Nose | + + + + + M M + + + + + + + + M + + + + + + + + +|
Lumen, Fungus | 3 |
Lumen, Inflammation, Suppurative | 1 3 1 2 |
Mucosa, Hyperplasia | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Submucosa, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + M + + + + + + + + + +|
Lumen, Exudate | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Middle Ear, Inflammation, Suppurative| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cataract | 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Retinal Detachment | |
Synechia | 3 |
Retina, Atrophy | 3 3 3 3 3 3 3 3 3 3 3 4 3 4 3 3 3 4 4|
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Chronic | 3 3 3 2 3 3 2 3 2 3 2 2 2 3|
Inflammation, Suppurative | 1 1 1 1 |
Nephropathy | 3 3 2 3 2 1 2 3 3 2 3 2 3 2 2 1 2 2 1 2 3 2 2 3|
Renal Tubule, Mineralization | 1 |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 2| 3| 2| 2| 2| 1| 6| 9| 2| 2| 9| 2| 9| 2| 2| 6| 2| 1| 2| 2| 2| 7| 2| 2| 2| |
| 3| 8| 9| 9| 9| 0| 0| 2| 9| 9| 2| 1| 2| 9| 9| 4| 3| 7| 9| 9| 3| 4| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
8.0 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + + M M + + + M + + + I + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cecum, Fibrosis | | 1 3.0|
Cecum, Mineralization | 3 | 1 3.0|
Cecum, Parasite Metazoan | 2 | 1 2.0|
Colon, Edema | 2 | 1 2.0|
Colon, Inflammation, Chronic Active | 3 | 1 3.0|
Rectum, Parasite Metazoan | 2 2 1 | 4 1.8|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duodenum, Erosion | 3 | 1 3.0|
Duodenum, Inflammation, Chronic | 2 | 1 2.0|
Duodenum, Inflammation, Suppurative | | 1 2.0|
Muscularis, Jejunum, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 2 3.0|
Basophilic Focus | X X X X | 10 |
Clear Cell Focus | X X X | 6 |
Cyst Multilocular | | 5 |
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Hemorrhage | | 2 3.0|
Inflammation, Chronic | 2 2 2 2 | 4 2.0|
Inflammation, Chronic Active | | 1 1.0|
Inflammation, Granulomatous | 2 | 2 2.0|
Mixed Cell Focus | | 1 |
Bile Duct, Hyperplasia | 2 2 3 2 2 1 2 2 2 2 1 2 2 1 4 3 3 3 2 2 1 2 2| 43 2.1|
Hepatocyte, Atrophy, Multifocal | 3 3 2 2 2| 9 2.4|
Hepatocyte, Hyperplasia, Nodular | 3 3 | 3 2.7|
Hepatocyte, Necrosis, Multifocal | | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 4 3 2 1 3 3 | 19 2.5|
Hepatocyte, Centrilobular, Necrosis | 2 | 1 2.0|
Portal, Fibrosis | 1 1 1 3 2 3 1| 15 1.9|
__________________________________________________________________________|____________|
Mesentery | + + + + | 8 |
Mineralization | 2 | 1 2.0|
Fat, Inflammation, Granulomatous | | 1 4.0|
Fat, Necrosis, Focal | 3 3 | 6 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 4 2 2 2 2 2 3| 18 2.3|
Hyperplasia | 3 2 2 2 2 3 2 | 9 2.4|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 2| 3| 2| 2| 2| 1| 6| 9| 2| 2| 9| 2| 9| 2| 2| 6| 2| 1| 2| 2| 2| 7| 2| 2| 2| |
| 3| 8| 9| 9| 9| 0| 0| 2| 9| 9| 2| 1| 2| 9| 9| 4| 3| 7| 9| 9| 3| 4| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
8.0 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Forestomach, Edema | 2 | 1 2.0|
Forestomach, Erosion | 2 | 2 2.5|
Forestomach, Fibrosis | | 1 3.0|
Forestomach, Inflammation, Chronic | 2 2| 2 2.0|
Forestomach, Inflammation, Chronic | | |
Active | | 1 3.0|
Forestomach, Mineralization | 2 | 1 2.0|
Forestomach, Perforation | X | 1 |
Forestomach, Ulcer | | 2 3.0|
Forestomach, Mucosa, Hyperplasia | 2 2 3 3 3| 6 2.7|
Glandular, Erosion | 3 | 1 3.0|
Glandular, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
Glandular, Mineralization | 2 3 | 4 2.3|
Glandular, Ulcer | 4 3 | 2 3.5|
__________________________________________________________________________|____________|
Tongue | + + | 2 |
Epithelium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 3 |
Inflammation, Chronic Active | 3 | 3 3.0|
Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Thrombosis | X X | 3 |
Myocardium, Fibrosis | 2 2 3 3 2 2 3 2 3 3 2 2 2 2 2 2 3 | 36 2.4|
Myocardium, Inflammation, Chronic | 1 2 | 3 2.0|
Myocardium, Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cortex, Hyperplasia | 2 | 1 2.0|
Cortex, Vacuolization Cytoplasmic | 2 2 1 2 3 3 | 13 2.0|
Extra Adrenal Tissue, Developmental | | |
Malformation | | 2 |
Medulla, Hyperplasia | 3 | 4 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 2| 3| 2| 2| 2| 1| 6| 9| 2| 2| 9| 2| 9| 2| 2| 6| 2| 1| 2| 2| 2| 7| 2| 2| 2| |
| 3| 8| 9| 9| 9| 0| 0| 2| 9| 9| 2| 1| 2| 9| 9| 4| 3| 7| 9| 9| 3| 4| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
8.0 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Angiectasis | | 1 2.0|
Pars Distalis, Angiectasis | 2 | 1 2.0|
Pars Distalis, Cyst | X X | 2 |
Pars Distalis, Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia | 2 3 1 | 3 2.0|
Pars Distalis, Necrosis | | 1 3.0|
Pars Intermedia, Cyst | X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ultimobranchial Cyst | | 2 |
C-Cell, Hyperplasia | 2 1 1 | 11 1.5|
Follicle, Dilatation | 2 3 | 4 2.8|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Ectasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 45 |
Ectasia | | 1 2.0|
Hyperplasia | | 5 3.0|
Inflammation, Chronic | 2 2 2 3 2 3 | 12 2.4|
Inflammation, Suppurative | 2 3 2 4 | 10 3.1|
__________________________________________________________________________|____________|
Prostate | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Corpora Amylacea | 3 3 3 | 3 3.0|
Edema | 4 | 1 4.0|
Inflammation, Chronic | | 2 2.0|
Inflammation, Suppurative | 2 2 2 4 3 2 2 3 2 | 17 2.2|
Epithelium, Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 2 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 4.0|
Hemorrhage | | 1 4.0|
Necrosis | | 1 4.0|
Interstitial Cell, Hyperplasia | 2 | 1 2.0|
Seminiferous Tubule, Atrophy | 3 3 | 3 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 2| 3| 2| 2| 2| 1| 6| 9| 2| 2| 9| 2| 9| 2| 2| 6| 2| 1| 2| 2| 2| 7| 2| 2| 2| |
| 3| 8| 9| 9| 9| 0| 0| 2| 9| 9| 2| 1| 2| 9| 9| 4| 3| 7| 9| 9| 3| 4| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
8.0 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Seminiferous Tubule, Mineralization | 3 2 2 3 1 2 2 | 14 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 3.0|
Hyperplasia, Reticulum Cell | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Hyperplasia, Plasma Cell | | 1 3.0|
Bronchial, Pigmentation | 3 | 1 3.0|
Inguinal, Hyperplasia, Plasma Cell | | 1 4.0|
Inguinal, Lymphatic, Ectasia | | 1 3.0|
Lumbar, Lymphatic, Ectasia | | 1 4.0|
Lymphatic, Mandibular, Ectasia | 2 3 2 3| 7 2.7|
Mandibular, Hyperplasia, Plasma Cell | 3 3 3 | 6 2.8|
Mediastinal, Atrophy | | 1 4.0|
Mediastinal, Erythrophagocytosis | | 1 3.0|
Mediastinal, Hemorrhage | 3 2 2 | 3 2.3|
Mediastinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mediastinal, Pigmentation | 3 3 | 3 3.0|
Mediastinal, Lymphatic, Ectasia | | 1 3.0|
Mesenteric, Atrophy | 4 3 | 5 3.2|
Mesenteric, Hemorrhage | 2 | 1 2.0|
Mesenteric, Hyperplasia, Lymphoid | | 1 3.0|
Mesenteric, Lymphatic, Ectasia | | 1 3.0|
Renal, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | | |
Granulocytic | 3 | 3 2.7|
Hematopoietic Cell Proliferation | | |
Erythrocytic | 2 2 3 2 2 | 8 2.3|
Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + I M M M M M M + + + + + + + I + + + + + + + +| 34 |
Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + M + + + + + + + + + + + + M + M + + + +| 46 |
Hyperplasia, Cystic | 3 2 4 2 3 4 | 12 2.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 2| 3| 2| 2| 2| 1| 6| 9| 2| 2| 9| 2| 9| 2| 2| 6| 2| 1| 2| 2| 2| 7| 2| 2| 2| |
| 3| 8| 9| 9| 9| 0| 0| 2| 9| 9| 2| 1| 2| 9| 9| 4| 3| 7| 9| 9| 3| 4| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
8.0 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Acanthosis | 2 3 4 | 3 3.0|
Cyst Epithelial Inclusion | X | 1 |
Exudate | 2 3 4 | 3 3.0|
Hyperkeratosis | 4 | 1 4.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Inflammation, Suppurative | 3 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Degeneration, Multiple | 2 3 2 | 4 2.5|
Necrosis | 2 | 1 2.0|
Cerebellum, Mineralization | 3 | 1 3.0|
Cerebrum, Degeneration | 2 | 1 2.0|
Cerebrum, Hemorrhage | | 1 3.0|
Cerebrum, Necrosis | | 1 3.0|
Thalamus, Degeneration | 2 | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + I + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenomatosis | 2 2 2| 3 2.0|
Edema, Diffuse | 3 | 1 3.0|
Foreign Body | | 2 2.5|
Hemorrhage | 2 | 2 2.5|
Infiltration Cellular, Histiocyte | 2 1 2 1 1 1 2 1 2 2 2 2 1 2 1 2 1| 29 1.6|
Inflammation, Granulomatous | 1 | 3 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Lumen, Fungus | | 1 3.0|
Lumen, Inflammation, Suppurative | 2 3 2 | 7 2.0|
Mucosa, Hyperplasia | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 | 1 3.0|
Submucosa, Inflammation, Chronic | 3 | 2 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 2| 3| 2| 2| 2| 1| 6| 9| 2| 2| 9| 2| 9| 2| 2| 6| 2| 1| 2| 2| 2| 7| 2| 2| 2| |
| 3| 8| 9| 9| 9| 0| 0| 2| 9| 9| 2| 1| 2| 9| 9| 4| 3| 7| 9| 9| 3| 4| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
8.0 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Lumen, Exudate | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
Middle Ear, Inflammation, Suppurative| 3 | 1 3.0|
__________________________________________________________________________|____________|
Eye | + + + + + + + + +| 28 |
Angiectasis | | 1 3.0|
Cataract | 1 2 3 3 2 2| 25 2.8|
Retinal Detachment | X | 1 |
Synechia | | 1 3.0|
Retina, Atrophy | 3 3 4 2 3 3 4 3 3| 28 3.2|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 1 2.0|
Inflammation, Chronic | 2 3 3 2 3 2 2 2 2 3 4 2 2| 27 2.5|
Inflammation, Suppurative | 2 1 1 1 | 8 1.1|
Nephropathy | 2 3 2 3 2 3 2 2 2 3 3 3 2 2 2 1 2 2 1 2 2 4 3 3 2| 49 2.3|
Renal Tubule, Mineralization | 1 2 1 1 1 | 6 1.2|
Renal Tubule, Pigmentation | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 4| 5| 7| 7|
DAY ON TEST | 0| 4| 6| 8| 3| 7| 3| 3| 3| 3| 2| 1| 8| 3| 3| 5| 3| 3| 3| 3| 0| 7| 1| 3| 3|
| 7| 5| 4| 4| 0| 7| 0| 0| 0| 0| 6| 8| 8| 0| 0| 8| 0| 0| 3| 3| 4| 7| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
4.0 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cecum, Erosion | |
Colon, Parasite Metazoan | 2 2 2 2 |
Rectum, Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duodenum, Mucosa, Hyperplasia | |
Ileum, Mineralization | |
Ileum, Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X |
Clear Cell Focus | X X X X |
Cyst Multilocular | X X |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic | 2 |
Inflammation, Granulomatous | |
Bile Duct, Hyperplasia | 3 3 2 4 2 2 4 2 1 2 3 2 2 2 3 2 2 3 3 2|
Hepatocyte, Atrophy, Multifocal | 3 2 2 2 2 |
Hepatocyte, Hyperplasia, Nodular | 3 2 2 2 |
Hepatocyte, Necrosis, Multifocal | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 3 4 3 2 4 |
Portal, Fibrosis | 3 2 1 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Ectopic Tissue | |
Fat, Fibrosis | |
Fat, Inflammation, Granulomatous | 3 |
Fat, Inflammation, Suppurative | 2 |
Fat, Necrosis, Focal | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + A + +|
Atrophy | 1 2 2 1 1 2 1|
Hyperplasia | 2 2 3 2 |
__________________________________________________________________________|
Pharynx | + |
Palate, Ulcer | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + M + +|
Atrophy | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Diverticulum | X |
Forestomach, Edema | 3 |
Forestomach, Inflammation, Chronic | |
Forestomach, Inflammation, | |
Suppurative | 2 |
Forestomach, Mineralization | |
Forestomach, Necrosis | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 4| 5| 7| 7|
DAY ON TEST | 0| 4| 6| 8| 3| 7| 3| 3| 3| 3| 2| 1| 8| 3| 3| 5| 3| 3| 3| 3| 0| 7| 1| 3| 3|
| 7| 5| 4| 4| 0| 7| 0| 0| 0| 0| 6| 8| 8| 0| 0| 8| 0| 0| 3| 3| 4| 7| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
4.0 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Forestomach, Perforation | X |
Forestomach, Ulcer | 4 |
Forestomach, Mucosa, Dysplasia | |
Forestomach, Mucosa, Hyperplasia | 4 2 3 1 2 |
Glandular, Erosion | 3 3 |
Glandular, Hemorrhage | |
Glandular, Mineralization | 3 1 2 3 2|
Glandular, Necrosis | |
Glandular, Ulcer | |
__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Hypertrophy | 3 |
Inflammation, Chronic Active | 3 2 |
Mineralization | |
Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Fibrosis | 2 3 2 2 2 3 2 2 2 2 2 2 3 3 3 3 3 2 2 2|
Myocardium, Inflammation, Chronic | 1 1 2 |
Myocardium, Inflammation, Chronic | |
Active | 2 |
Myocardium, Metaplasia, Osseous | |
Myocardium, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 |
Pigmentation | 4 |
Cortex, Cyst | |
Cortex, Hematocyst | X |
Cortex, Hyperplasia | 2 |
Cortex, Necrosis | 4 |
Cortex, Vacuolization Cytoplasmic | 2 2 3 2 2|
Extra Adrenal Tissue, Developmental | |
Malformation | |
Medulla, Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + A + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + M + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Pars Distalis, Angiectasis | 2 |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 4| 5| 7| 7|
DAY ON TEST | 0| 4| 6| 8| 3| 7| 3| 3| 3| 3| 2| 1| 8| 3| 3| 5| 3| 3| 3| 3| 0| 7| 1| 3| 3|
| 7| 5| 4| 4| 0| 7| 0| 0| 0| 0| 6| 8| 8| 0| 0| 8| 0| 0| 3| 3| 4| 7| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
4.0 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 3 2 2 |
Pars Intermedia, Angiectasis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 3 |
Follicle, Pigmentation | 2 2|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + M + + + + + + + + + + + + M M M + + +|
Ectasia | 4 3 3 |
Hyperplasia | 2 |
Inflammation, Chronic | 2 3 2 2 2 2 3 |
Inflammation, Suppurative | 4 2 2 2 4|
Metaplasia, Squamous | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | |
Foreign Body | |
Inflammation, Granulomatous | |
Inflammation, Suppurative | 3 4 1 2 3 2 1 1 3 2 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + |
Fibrosis | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 3 3 4|
Seminiferous Tubule, Mineralization | 3 3 2 2 2 2 2 2 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 2|
Hyperplasia, Reticulum Cell | 1 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphatic, Mandibular, Ectasia | 3 3 |
Mandibular, Hyperplasia, Lymphoid | |
Mandibular, Hyperplasia, Plasma Cell | 2 2 |
Mediastinal, Erythrophagocytosis | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 4| 5| 7| 7|
DAY ON TEST | 0| 4| 6| 8| 3| 7| 3| 3| 3| 3| 2| 1| 8| 3| 3| 5| 3| 3| 3| 3| 0| 7| 1| 3| 3|
| 7| 5| 4| 4| 0| 7| 0| 0| 0| 0| 6| 8| 8| 0| 0| 8| 0| 0| 3| 3| 4| 7| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
4.0 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Hemorrhage | 3 3 |
Mediastinal, Hyperplasia, Histiocytic| |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 3 |
Mediastinal, Pigmentation | 3 |
Mediastinal, Lymphatic, Ectasia | |
Mesenteric, Atrophy | 3 |
Mesenteric, Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Fibrosis | 3 3 |
Hematopoietic Cell Proliferation | |
Granulocytic | 2 3|
Hematopoietic Cell Proliferation | |
Erythrocytic | 2 3 2 2 2 2|
Necrosis | 4 |
Pigmentation, Hemosiderin | |
Lymphatic, Ectasia | 2 |
__________________________________________________________________________|
Thymus | M + + + + + + M M + I M + + + M + + M + + + M + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + M + M + + + + + + + + M M|
Angiectasis | 4 |
Hyperplasia, Cystic | 2 3 2 2 1 1 |
Hyperplasia, Lobular | |
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + M +|
Acanthosis | 3 |
Cyst Epithelial Inclusion | X |
Edema | |
Hyperkeratosis | 2 |
Inflammation, Chronic | |
Inflammation, Suppurative | 3 |
Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Necrosis | |
__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 4| 5| 7| 7|
DAY ON TEST | 0| 4| 6| 8| 3| 7| 3| 3| 3| 3| 2| 1| 8| 3| 3| 5| 3| 3| 3| 3| 0| 7| 1| 3| 3|
| 7| 5| 4| 4| 0| 7| 0| 0| 0| 0| 6| 8| 8| 0| 0| 8| 0| 0| 3| 3| 4| 7| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
4.0 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
Degeneration, Multiple | 1 3 |
Cerebrum, Degeneration | 1 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | 2 |
Edema, Diffuse | |
Foreign Body | 4 3 2 3 |
Hemorrhage | 3 |
Infiltration Cellular, Histiocyte | 1 2 2 1 3 1 1 1 1 1 1 1 1 2|
Inflammation, Chronic | |
Inflammation, Granulomatous | 2 |
Metaplasia, Osseous | |
Pigmentation | 3 |
Artery, Media, Hypertrophy | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + M + + + +|
Lumen, Foreign Body | |
Lumen, Fungus | 3 |
Lumen, Hemorrhage | 2 |
Lumen, Inflammation, Suppurative | 2 |
Mucosa, Metaplasia, Squamous | 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Nasopharyngeal Duct, Foreign Body | |
Nasopharyngeal Duct, Inflammation, | |
Suppurative | |
Submucosa, Inflammation, Chronic | 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + M |
Cataract | 3 |
Retina, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic | 3 3 3 2 2 2 3 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 4| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 4| 5| 7| 7|
DAY ON TEST | 0| 4| 6| 8| 3| 7| 3| 3| 3| 3| 2| 1| 8| 3| 3| 5| 3| 3| 3| 3| 0| 7| 1| 3| 3|
| 7| 5| 4| 4| 0| 7| 0| 0| 0| 0| 6| 8| 8| 0| 0| 8| 0| 0| 3| 3| 4| 7| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
4.0 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Suppurative | 2 1 |
Nephropathy | 1 2 3 1 4 2 3 3 2 2 3 1 1 3 2 2 2 2 2 1 1 1 3 2|
Pelvis, Mineralization | |
Pelvis, Epithelium, Hyperplasia | |
Renal Tubule, Mineralization | 1 2 1 1|
Renal Tubule, Pigmentation | 2 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 8| 5| 3| 3| 4| 9| 3| 3| 3| 6| 3| 9| 9| 3| 6| 4| 3| 3| 3| 7| 9| 3| 3| 3| |
| 3| 6| 3| 3| 3| 4| 5| 3| 3| 3| 8| 4| 5| 8| 3| 1| 5| 3| 3| 3| 9| 1| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
4.0 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cecum, Erosion | 3 | 1 3.0|
Colon, Parasite Metazoan | 2 1 | 6 1.8|
Rectum, Parasite Metazoan | 2 2 2| 4 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duodenum, Mucosa, Hyperplasia | 4 | 1 4.0|
Ileum, Mineralization | 3 | 1 3.0|
Ileum, Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 3 3| 3 3.0|
Basophilic Focus | X X X X X X X| 12 |
Clear Cell Focus | X X X| 7 |
Cyst Multilocular | X X X X | 6 |
Hematopoietic Cell Proliferation | | 1 2.0|
Inflammation, Chronic | 2 2 2 2 1 | 6 1.8|
Inflammation, Granulomatous | 2 | 1 2.0|
Bile Duct, Hyperplasia | 2 2 2 1 3 3 2 2 2 4 2 4 2 4 2 2 2 2 3| 39 2.4|
Hepatocyte, Atrophy, Multifocal | 3 2 2 | 8 2.3|
Hepatocyte, Hyperplasia, Nodular | 3 2 | 6 2.3|
Hepatocyte, Necrosis, Multifocal | | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 3 3 2 3 2 | 13 2.8|
Portal, Fibrosis | 2 2 1 1 3 3 1 | 14 1.9|
__________________________________________________________________________|____________|
Mesentery | + + | 7 |
Ectopic Tissue | X | 1 |
Fat, Fibrosis | 3 | 1 3.0|
Fat, Inflammation, Granulomatous | | 1 3.0|
Fat, Inflammation, Suppurative | 3 | 2 2.5|
Fat, Necrosis, Focal | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 4 1 2 3 2 2 | 14 1.9|
Hyperplasia | 2 3 2 3 2| 9 2.3|
__________________________________________________________________________|____________|
Pharynx | + | 2 |
Palate, Ulcer | 3 | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
Forestomach, Diverticulum | | 1 |
Forestomach, Edema | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 8| 5| 3| 3| 4| 9| 3| 3| 3| 6| 3| 9| 9| 3| 6| 4| 3| 3| 3| 7| 9| 3| 3| 3| |
| 3| 6| 3| 3| 3| 4| 5| 3| 3| 3| 8| 4| 5| 8| 3| 1| 5| 3| 3| 3| 9| 1| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
4.0 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Forestomach, Inflammation, Chronic | 2 | 1 2.0|
Forestomach, Inflammation, | | |
Suppurative | | 1 2.0|
Forestomach, Mineralization | 3 2 | 2 2.5|
Forestomach, Necrosis | 4 | 1 4.0|
Forestomach, Perforation | X | 2 |
Forestomach, Ulcer | 3 4 | 3 3.7|
Forestomach, Mucosa, Dysplasia | 1 | 1 1.0|
Forestomach, Mucosa, Hyperplasia | 3 4 2 | 8 2.6|
Glandular, Erosion | 2 | 3 2.7|
Glandular, Hemorrhage | 3 | 1 3.0|
Glandular, Mineralization | 3 2 2 1 | 9 2.1|
Glandular, Necrosis | 3 | 1 3.0|
Glandular, Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 4 |
Hypertrophy | 3 | 2 3.0|
Inflammation, Chronic Active | 3 | 3 2.7|
Mineralization | 2 | 1 2.0|
Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myocardium, Fibrosis | 2 3 2 2 2 2 3 2 2 2 3 3 2 2 3 2 3 3| 38 2.4|
Myocardium, Inflammation, Chronic | 2 2 2 1 1 2| 9 1.6|
Myocardium, Inflammation, Chronic | | |
Active | 2 | 2 2.0|
Myocardium, Metaplasia, Osseous | 2 | 1 2.0|
Myocardium, Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 4.0|
Pigmentation | | 1 4.0|
Cortex, Cyst | X | 1 |
Cortex, Hematocyst | | 1 |
Cortex, Hyperplasia | 2 3 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 8| 5| 3| 3| 4| 9| 3| 3| 3| 6| 3| 9| 9| 3| 6| 4| 3| 3| 3| 7| 9| 3| 3| 3| |
| 3| 6| 3| 3| 3| 4| 5| 3| 3| 3| 8| 4| 5| 8| 3| 1| 5| 3| 3| 3| 9| 1| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
4.0 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Cortex, Necrosis | | 1 4.0|
Cortex, Vacuolization Cytoplasmic | 2 2 2 | 8 2.1|
Extra Adrenal Tissue, Developmental | | |
Malformation | X X | 2 |
Medulla, Hyperplasia | 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + I + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Angiectasis | 3| 2 2.5|
Pars Distalis, Cyst | X X X X | 5 |
Pars Distalis, Hyperplasia | 1 | 4 2.0|
Pars Intermedia, Angiectasis | 2| 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ultimobranchial Cyst | X X | 2 |
C-Cell, Hyperplasia | 1 1 | 4 1.8|
Follicle, Pigmentation | | 2 2.0|
Follicular Cell, Hyperplasia | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Ectasia | 2 4 3 | 6 3.2|
Hyperplasia | 4 3 | 3 3.0|
Inflammation, Chronic | 2 3 2 3 3 2 2 2 2| 16 2.3|
Inflammation, Suppurative | 2 2 3 4 3 2 2 2| 13 2.6|
Metaplasia, Squamous | | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Corpora Amylacea | 2 3 2 2| 4 2.3|
Foreign Body | 2 | 1 2.0|
Inflammation, Granulomatous | 4 | 1 4.0|
Inflammation, Suppurative | 2 2 2 3 3 3 4 2| 18 2.4|
Epithelium, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 4 |
Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 8| 5| 3| 3| 4| 9| 3| 3| 3| 6| 3| 9| 9| 3| 6| 4| 3| 3| 3| 7| 9| 3| 3| 3| |
| 3| 6| 3| 3| 3| 4| 5| 3| 3| 3| 8| 4| 5| 8| 3| 1| 5| 3| 3| 3| 9| 1| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
4.0 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Seminiferous Tubule, Atrophy | 3 2 3 | 6 3.0|
Seminiferous Tubule, Mineralization | 2 2 3 2 2 2 2 3 2 3| 20 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Hyperplasia | 3 | 2 2.5|
Hyperplasia, Reticulum Cell | | 1 1.0|
Myelofibrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphatic, Mandibular, Ectasia | 3 2 | 4 2.8|
Mandibular, Hyperplasia, Lymphoid | 3 3 | 2 3.0|
Mandibular, Hyperplasia, Plasma Cell | 3 3 3 2 2 | 7 2.4|
Mediastinal, Erythrophagocytosis | 3 3 4 | 3 3.3|
Mediastinal, Hemorrhage | 3 4 | 4 3.3|
Mediastinal, Hyperplasia, Histiocytic| 3 | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 3.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Mediastinal, Pigmentation | 4 3 | 3 3.3|
Mediastinal, Lymphatic, Ectasia | 3 3 | 2 3.0|
Mesenteric, Atrophy | 3 | 2 3.0|
Mesenteric, Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 3 3 | 3 2.7|
Fibrosis | 2 3 3 2 | 6 2.7|
Hematopoietic Cell Proliferation | | |
Granulocytic | | 2 2.5|
Hematopoietic Cell Proliferation | | |
Erythrocytic | 3 2 | 8 2.3|
Necrosis | 3 | 2 3.5|
Pigmentation, Hemosiderin | 3 | 1 3.0|
Lymphatic, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M M M + M M M M + M + + + I M M M M + + + + + + +| 29 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 8| 5| 3| 3| 4| 9| 3| 3| 3| 6| 3| 9| 9| 3| 6| 4| 3| 3| 3| 7| 9| 3| 3| 3| |
| 3| 6| 3| 3| 3| 4| 5| 3| 3| 3| 8| 4| 5| 8| 3| 1| 5| 3| 3| 3| 9| 1| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
4.0 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + + M +| 44 |
Angiectasis | | 1 4.0|
Hyperplasia, Cystic | 1 2 2 2 1 1 2 | 13 1.7|
Hyperplasia, Lobular | 3 | 1 3.0|
Inflammation, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 2 2 2 | 4 2.3|
Cyst Epithelial Inclusion | | 1 |
Edema | 2 | 1 2.0|
Hyperkeratosis | 3 2 | 3 2.3|
Inflammation, Chronic | 3 3 3 | 3 3.0|
Inflammation, Suppurative | 2 | 2 2.5|
Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Inflammation, Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 1 2.0|
Degeneration, Multiple | 3 3 2 3 3 4 | 8 2.8|
Cerebrum, Degeneration | | 1 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + M + M + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenomatosis | 3 2 2 | 4 2.3|
Edema, Diffuse | 2 3 | 2 2.5|
Foreign Body | 2 2 | 6 2.7|
Hemorrhage | | 1 3.0|
Infiltration Cellular, Histiocyte | 1 1 1 2 1 3 1 1 1 1 1 1 1| 27 1.3|
Inflammation, Chronic | 2 3 | 2 2.5|
Inflammation, Granulomatous | 3 | 2 2.5|
Metaplasia, Osseous | 1 | 1 1.0|
Pigmentation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05049-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DICHLORVOS Date: 05/06/97
Route: GAVAGE Time: 11:18:24
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 8| 5| 3| 3| 4| 9| 3| 3| 3| 6| 3| 9| 9| 3| 6| 4| 3| 3| 3| 7| 9| 3| 3| 3| |
| 3| 6| 3| 3| 3| 4| 5| 3| 3| 3| 8| 4| 5| 8| 3| 1| 5| 3| 3| 3| 9| 1| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
4.0 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Artery, Media, Hypertrophy | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lumen, Foreign Body | 3 | 1 3.0|
Lumen, Fungus | | 1 3.0|
Lumen, Hemorrhage | | 1 2.0|
Lumen, Inflammation, Suppurative | 3 2 | 3 2.3|
Mucosa, Metaplasia, Squamous | | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 2 2.0|
Nasopharyngeal Duct, Foreign Body | 3 | 1 3.0|
Nasopharyngeal Duct, Inflammation, | | |
Suppurative | 2 | 1 2.0|
Submucosa, Inflammation, Chronic | 2 | 3 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | M| |
__________________________________________________________________________|____________|
Eye | + M | 2 |
Cataract | | 1 3.0|
Retina, Atrophy | 2 | 2 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Inflammation, Chronic | 2 3 2 2 2 2 3 3 2 2 4 4 3 3 2 3 2 2| 30 2.5|
Inflammation, Suppurative | 1 1 2 2 | 6 1.5|
Nephropathy | 1 2 2 2 3 3 3 2 3 2 1 3 3 3 3 2 1 4 3 3 4 2 3 2 2| 49 2.3|
Pelvis, Mineralization | 2 | 1 2.0|
Pelvis, Epithelium, Hyperplasia | 3 | 1 3.0|
Renal Tubule, Mineralization | 1 1 2 1 1 1 1 1| 12 1.2|
Renal Tubule, Pigmentation | 2 | 3 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
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