TDMS Study 05052-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
2,4-DICHLOROPHENOL
NTP Experiment-Test: 05052-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/07/94
Route: DOSED FEED Time: 23:47:53
Facility: Battelle Columbus Laboratory
Chemical CAS #: 120-83-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05052-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 23:47:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 4 10 5
Moribund 1 2
Survivors
Terminal Sacrifice 45 40 43
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (46) (45)
Mucosa, Cyst 1 (2%)
Intestine Small (48) (2) (47)
Ileum, Peyer's Patch, Inflammation, Acute,
Focal 1 (2%)
Jejunum, Peyer's Patch, Hyperplasia, Diffuse,
Lymphoid 1 (50%)
Jejunum, Peyer's Patch, Hyperplasia,
Lymphoid, Multifocal 1 (2%)
Liver (50) (6) (50)
Basophilic Focus, Multiple 1 (2%)
Basophilic Focus, Single 2 (4%) 2 (4%)
Clear Cell Focus 1 (2%)
Eosinophilic Focus, Single 1 (17%)
Hematopoietic Cell Proliferation, Multifocal 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%)
Inflammation, Granulomatous, Multifocal 1 (2%)
Inflammation, Multifocal, Subacute 1 (2%)
Hepatocyte, Hyperplasia, Focal 1 (2%)
Hepatocyte, Inflammation, Acute, Focal 2 (4%)
Hepatocyte, Inflammation, Multifocal,
Necrotizing, Subacute 1 (2%)
Hepatocyte, Necrosis, Acute, Diffuse 1 (2%)
Hepatocyte, Necrosis, Acute, Multifocal 1 (17%) 2 (4%)
Hepatocyte, Nuclear Alteration, Focal 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic, Focal 1 (2%) 1 (17%)
Kupffer Cell, Pigmentation, Multifocal 1 (2%)
Left Lateral Lobe, Angiectasis, Focal 1 (2%)
Mesentery (47) (1) (48)
Inflammation, Acute, Multifocal 1 (2%)
Inflammation, Multifocal, Subacute 1 (2%)
Thrombosis 1 (2%)
Fat, Necrosis, Chronic, Focal 1 (100%)
Fat, Necrosis, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05052-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 23:47:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (49) (47)
Cyst, Multifocal 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%)
Acinus, Atrophy, Diffuse 1 (2%) 1 (2%)
Acinus, Atrophy, Focal 1 (2%) 1 (2%)
Acinus, Atrophy, Multifocal 1 (2%) 2 (4%)
Pharynx (1)
Palate, Epithelium, Hyperplasia 1 (100%)
Salivary Glands (49) (47)
Infiltration Cellular, Focal, Lymphocyte 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%)
Stomach (49) (14) (48)
Forestomach, Erosion, Focal 1 (2%)
Forestomach, Epithelium, Hyperplasia, Focal 10 (20%) 10 (71%) 4 (8%)
Mucosa, Glandular, Mineralization, Diffuse 1 (2%)
Tooth (48) (44)
Peridontal Tissue, Inflammation, Acute, Focal 1 (2%) 1 (2%)
Peridontal Tissue, Inflammation, Focal,
Granulomatous 1 (2%)
Peridontal Tissue, Inflammation, Focal,
Necrotizing 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (1) (50)
Myocardium, Mineralization, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (1) (50)
Cortex, Focal Cellular Change 3 (6%)
Cortex, Hyperplasia, Focal 2 (4%)
Medulla, Hyperplasia, Focal 2 (4%)
Medulla, Hypertrophy 1 (2%)
Spindle Cell, Hyperplasia, Diffuse 45 (92%) 47 (94%)
Spindle Cell, Hyperplasia, Multifocal 1 (2%) 1 (2%)
Subcapsular, Cyst 1 (2%)
Parathyroid Gland (39) (38)
Cyst 1 (3%)
Hyperplasia, Focal 1 (3%)
Pituitary Gland (49) (48)
Pars Distalis, Angiectasis, Focal 1 (2%) 1 (2%)
Pars Distalis, Cyst 1 (2%)
Pars Distalis, Hyperplasia, Focal 3 (6%) 3 (6%)
Pars Distalis, Hyperplasia, Multifocal 3 (6%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05052-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 23:47:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Intermedia, Hyperplasia, Focal 2 (4%)
Thyroid Gland (49) (47)
Ectopic Tissue 1 (2%)
Follicle, Cyst 2 (4%)
Follicle, Cyst, Multiple 1 (2%) 1 (2%)
Follicle, Inflammation, Focal, Granulomatous 1 (2%)
Follicle, Inflammation, Multifocal, Subacute 1 (2%)
Follicular Cell, Hyperplasia, Cystic, Focal 1 (2%)
Follicular Cell, Hyperplasia, Multifocal 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (48) (22) (48)
Angiectasis, Diffuse 1 (2%)
Cyst 1 (2%)
Hyperplasia, Focal 1 (2%)
Bilateral, Abscess, Chronic Active,
Multifocal 1 (2%) 1 (5%)
Bilateral, Periovarian Tissue, Cyst 1 (2%) 2 (9%) 2 (4%)
Follicle, Cyst 2 (4%) 2 (9%) 5 (10%)
Left, Abscess, Chronic, Focal 2 (9%)
Left, Follicle, Cyst 2 (4%) 1 (5%) 1 (2%)
Periovarian Tissue, Cyst 1 (2%) 3 (14%) 5 (10%)
Periovarian Tissue, Right, Cyst 4 (8%) 6 (27%) 2 (4%)
Periovarian Tissue, Left, Cyst 3 (6%) 4 (18%) 3 (6%)
Right, Abscess, Chronic Active, Single 1 (5%)
Right, Follicle, Cyst 1 (2%) 1 (5%)
Uterus (49) (40) (49)
Hyperplasia, Cystic, Diffuse, Glandular 1 (2%)
Endometrium, Angiectasis 1 (2%)
Endometrium, Angiectasis, Focal 1 (2%)
Endometrium, Hyperplasia, Cystic, Diffuse,
Glandular 48 (98%) 38 (95%) 44 (90%)
Endometrium, Inflammation, Focal, Suppurative 1 (3%)
Endometrium, Metaplasia, Squamous 1 (2%) 1 (2%)
Lumen, Dilatation 3 (6%) 1 (2%)
Lumen, Dilatation, Diffuse 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05052-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 23:47:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50)
Femoral, Hyperplasia, Diffuse, Neutrophil 1 (2%)
Lymph Node (48) (9) (46)
Bronchial, Hyperplasia, Diffuse, Lymphoid 1 (2%)
Lumbar, Hyperplasia, Diffuse, Lymphoid 1 (11%)
Lumbar, Sinus, Ectasia, Focal 1 (2%)
Mandibular, Hyperplasia, Diffuse, Lymphoid 1 (2%)
Mediastinal, Hyperplasia, Diffuse, Lymphoid 1 (2%)
Mediastinal, Pigmentation, Diffuse 1 (2%)
Mesenteric, Angiectasis, Diffuse 5 (10%)
Mesenteric, Angiectasis, Multifocal 1 (11%)
Mesenteric, Hyperplasia, Diffuse, Lymphoid 1 (11%)
Renal, Hyperplasia, Diffuse, Lymphoid 1 (11%) 1 (2%)
Spleen (49) (9) (49)
Inflammation, Chronic 1 (11%)
Capsule, Inflammation, Acute, Diffuse 1 (2%)
Lymphoid Follicle, Depletion Lymphoid,
Diffuse 2 (4%) 1 (2%)
Lymphoid Follicle, Hyperplasia, Diffuse,
Lymphoid 2 (4%) 1 (11%) 4 (8%)
Lymphoid Follicle, Hyperplasia, Lymphoid 1 (2%)
Lymphoid Follicle, Hyperplasia, Lymphoid,
Multifocal 1 (2%) 1 (2%)
Red Pulp, Angiectasis, Multifocal 1 (2%)
Red Pulp, Hematopoietic Cell Proliferation,
Diffuse 4 (8%) 2 (22%) 2 (4%)
Thymus (47) (1) (42)
Atrophy, Diffuse 1 (2%)
Depletion Lymphoid, Diffuse 2 (4%) 1 (2%)
Medulla, Hyperplasia, Diffuse, Lymphoid 2 (5%)
Thymocyte, Necrosis, Acute, Diffuse 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (48) (1) (49)
Face, Subcutaneous Tissue, Inflammation,
Focal, Granulomatous 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (2) (50)
Cranium, Myelofibrosis 2 (4%)
Cranium, Myelofibrosis, Focal 1 (2%)
Cranium, Myelofibrosis, Multifocal 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05052-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 23:47:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - CONT
Cranium, Femur, Myelofibrosis, Diffuse 2 (4%)
Cranium, Femur, Myelofibrosis, Multifocal 7 (14%)
Femur, Myelofibrosis, Diffuse 2 (4%) 1 (2%)
Femur, Myelofibrosis, Focal 4 (8%) 5 (10%)
Femur, Myelofibrosis, Multifocal 19 (38%) 12 (24%)
Vertebra, Myelofibrosis, Multifocal 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (48)
Compression, Focal 1 (2%) 1 (2%)
Meninges, Infiltration Cellular, Multifocal,
Lymphocyte 3 (6%) 1 (2%)
Thalamus, Mineralization 4 (8%) 3 (6%)
Third Ventricle, Infiltration Cellular,
Multifocal, Lymphocyte 1 (2%)
Spinal Cord (1)
Thoracic, Hemorrhage, Acute, Focal 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (1) (50)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%) 1 (2%)
Inflammation, Focal, Granulomatous 1 (2%)
Inflammation, Focal, Subacute 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 3 (6%) 3 (6%)
Interstitium, Inflammation, Focal, Subacute 1 (2%)
Mediastinum, Infiltration Cellular,
Multifocal, Lymphocyte 1 (2%)
Vein, Intima, Mineralization, Focal 1 (2%)
Nose (48) (44)
Mucosa, Inflammation, Acute, Multifocal 1 (2%)
Submucosa, Glands, Ectasia, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Developmental Malformation 1 (100%)
Harderian Gland (35) (2) (41)
Hyperplasia, Focal 1 (3%) 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05052-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 23:47:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50)
Infiltration Cellular, Multifocal, Lymphocyte 4 (8%)
Capsule, Inflammation, Diffuse, Subacute 1 (2%)
Capsule, Inflammation, Multifocal, Subacute 1 (2%)
Cortex, Infarct, Chronic 1 (2%)
Cortex, Metaplasia, Focal, Osseous 1 (2%)
Glomerulus, Inflammation, Diffuse, Subacute,
Membranoproliferative 1 (2%)
Glomerulus, Inflammation, Diffuse,
Proliferative 1 (2%)
Interstitial Tissue, Inflammation, Multifocal 1 (2%)
Renal Tubule, Casts Protein, Diffuse 1 (2%)
Renal Tubule, Cytoplasmic Alteration, Diffuse 1 (2%)
Renal Tubule, Cytoplasmic Alteration,
Multifocal 1 (2%)
Renal Tubule, Degeneration 1 (2%)
Renal Tubule, Degeneration, Diffuse 1 (2%)
Renal Tubule, Inflammation, Multifocal,
Necrotizing, Subacute 1 (2%)
Renal Tubule, Necrosis, Acute, Multifocal 1 (2%)
Renal Tubule, Pigmentation, Diffuse 1 (2%)
Renal Tubule, Regeneration, Focal 3 (6%)
Renal Tubule, Regeneration, Multifocal 2 (4%) 7 (14%)
Urinary Bladder (48) (47)
Serosa, Inflammation, Acute, Multifocal 1 (2%)
Submucosa, Infiltration Cellular, Multifocal,
Lymphocyte 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05052-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 23:47:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 12 14 12
Moribund 5 4 3
Drowned 4
Survivors
Terminal Sacrifice 33 32 31
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large (48) (1) (45)
Colon, Parasite Metazoan, Single 1 (2%) 1 (2%)
Intestine Small (44) (1) (41)
Thrombosis, Acute, Multifocal 1 (2%)
Jejunum, Peyer's Patch, Hyperplasia,
Lymphoid, Multifocal 1 (2%)
Liver (50) (49) (48)
Basophilic Focus, Multiple 1 (2%) 1 (2%)
Basophilic Focus, Single 2 (4%) 1 (2%) 2 (4%)
Inflammation, Granulomatous, Multifocal 1 (2%)
Inflammation, Multifocal, Subacute 1 (2%) 1 (2%)
Bile Duct, Hyperplasia, Multifocal 1 (2%)
Caudate Lobe, Necrosis, Chronic Active, Focal 1 (2%)
Hepatocyte, Cytomegaly 1 (2%)
Hepatocyte, Cytomegaly, Diffuse 1 (2%)
Hepatocyte, Cytomegaly, Multifocal 1 (2%)
Hepatocyte, Necrosis, Acute, Diffuse 3 (6%)
Hepatocyte, Necrosis, Acute, Focal 1 (2%)
Hepatocyte, Necrosis, Acute, Multifocal 2 (4%) 6 (12%)
Hepatocyte, Necrosis, Coagulative,
Multifocal, Subacute 1 (2%)
Hepatocyte, Nuclear Alteration, Diffuse 2 (4%)
Hepatocyte, Nuclear Alteration, Focal 15 (30%) 27 (55%) 18 (38%)
Hepatocyte, Nuclear Alteration, Multifocal 2 (4%) 3 (6%)
Hepatocyte, Syncytial Alteration, Diffuse 11 (22%) 33 (67%) 42 (88%)
Hepatocyte, Vacuolization Cytoplasmic, Focal 1 (2%)
Sinusoid, Infiltration Cellular, Diffuse,
Polymorphonuclear 1 (2%)
Mesentery (21) (1) (37)
Fat, Necrosis, Acute, Diffuse 1 (3%)
Fat, Necrosis, Multifocal 1 (100%)
Pancreas (49) (45)
Acinus, Atrophy, Focal 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05052-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 23:47:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Salivary Glands (50) (49)
Periductular, Infiltration Cellular,
Multifocal, Lymphocyte 1 (2%)
Stomach (48) (6) (46)
Forestomach, Epithelium, Hyperplasia, Focal 5 (10%) 6 (100%) 4 (9%)
Glandular, Dysplasia, Focal 1 (2%)
Glandular, Inflammation, Acute, Focal 1 (2%)
Tooth (40) (34)
Peridontal Tissue, Inflammation, Acute, Focal 2 (5%) 1 (3%)
Peridontal Tissue, Inflammation, Acute,
Multifocal 2 (5%) 1 (3%)
Peridontal Tissue, Inflammation, Chronic
Active, Focal 6 (15%)
Peridontal Tissue, Inflammation, Chronic
Active, Multifocal 1 (3%) 2 (6%)
Peridontal Tissue, Inflammation, Focal,
Subacute 1 (3%)
Pulp, Inflammation, Acute, Focal 3 (8%)
Pulp, Inflammation, Acute, Focal, Necrotizing 1 (3%)
Pulp, Necrosis, Acute, Diffuse 1 (3%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (1) (50)
Myocardium, Inflammation, Acute, Focal,
Suppurative 1 (2%)
Myocardium, Inflammation, Acute, Multifocal 1 (2%)
Myocardium, Inflammation, Chronic, Focal 1 (2%)
Myocardium, Inflammation, Multifocal,
Subacute 1 (2%)
Ventricle Right, Necrosis, Chronic, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (45)
Accessory Adrenal Cortical Nodule 1 (2%)
Accessory Adrenal Cortical Nodule, Focal 1 (2%)
Cortex, Degeneration, Fatty, Focal 1 (2%)
Cortex, Focal Cellular Change 4 (8%) 4 (9%)
Cortex, Focal Cellular Change, Multifocal 1 (2%) 2 (4%)
Cortex, Hyperplasia, Focal 3 (6%) 1 (2%)
Cortex, Hypertrophy 3 (7%)
Medulla, Hyperplasia, Focal 1 (2%) 1 (2%)
Spindle Cell, Hyperplasia, Focal 1 (2%)
Spindle Cell, Hyperplasia, Multifocal 7 (14%) 5 (11%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05052-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 23:47:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Parathyroid Gland (38) (35)
Infiltration Cellular, Focal, Lymphocyte 1 (3%)
Pituitary Gland (45) (47)
Pars Distalis, Inflammation, Acute, Focal 1 (2%)
Thyroid Gland (50) (48)
Follicle, Cyst, Multiple 2 (4%)
Follicle, Cyst, Single 5 (10%) 2 (4%)
Follicular Cell, Hyperplasia, Focal 1 (2%)
Follicular Cell, Hyperplasia, Multifocal 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (4) (20)
Wall, Inflammation, Acute, Multifocal 1 (25%)
Epididymis (48) (48)
Granuloma Sperm, Focal 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Epithelium, Inflammation, Diffuse,
Necrotizing 1 (2%)
Penis (5) (4) (2)
Inflammation, Acute, Focal 1 (20%) 1 (50%)
Preputial Gland (10) (5) (9)
Abscess, Chronic, Focal 3 (30%) 1 (20%) 1 (11%)
Abscess, Focal, Subacute 1 (11%)
Bilateral, Abscess, Chronic 2 (20%)
Bilateral, Inflammation, Granulomatous,
Multifocal, Suppurative 1 (10%)
Duct, Ectasia, Focal 1 (10%) 1 (20%) 2 (22%)
Duct, Ectasia, Multifocal 1 (10%) 1 (20%) 3 (33%)
Left, Abscess, Chronic, Focal 1 (20%)
Right, Abscess, Chronic, Focal 1 (10%)
Right, Abscess, Chronic Active, Focal 1 (20%)
Prostate (48) (49) (49)
Dilatation 1 (2%) 1 (2%)
Dilatation, Diffuse 2 (4%) 1 (2%)
Granuloma, Focal 1 (2%)
Inflammation, Acute, Diffuse 1 (2%) 1 (2%)
Inflammation, Acute, Multifocal 5 (10%)
Inflammation, Acute, Multifocal, Suppurative 1 (2%)
Inflammation, Multifocal, Necrotizing,
Subacute 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05052-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 23:47:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Artery, Inflammation, Chronic, Multifocal 1 (2%)
Seminal Vesicle (17) (2) (15)
Dilatation 3 (20%)
Dilatation, Diffuse 2 (100%)
Inflammation, Acute, Focal 1 (6%)
Lumen, Dilatation 2 (13%)
Lumen, Dilatation, Diffuse 1 (6%) 1 (7%)
Parenchyma, Inflammation, Acute, Multifocal 1 (7%)
Serosa, Inflammation, Acute, Diffuse 1 (7%)
Testes (48) (1) (48)
Germinal Epithelium, Atrophy, Diffuse 1 (2%)
Germinal Epithelium, Atrophy, Focal 1 (2%)
Germinal Epithelium, Atrophy, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (12) (6)
Leukocytosis 1 (8%)
Neutrophilia 1 (17%)
Bone Marrow (50) (49)
Femoral, Hyperplasia, Diffuse, Neutrophil 1 (2%) 1 (2%)
Femoral, Hypoplasia, Focal 1 (2%)
Femoral, Thrombosis, Focal, Subacute 1 (2%)
Lymph Node (48) (11) (47)
Inguinal, Hyperplasia, Diffuse, Lymphoid 1 (2%)
Inguinal, Infiltration Cellular, Diffuse,
Plasma Cell 1 (2%)
Lumbar, Hemorrhage, Acute, Diffuse 1 (2%)
Lumbar, Hyperplasia, Diffuse, Plasma Cell 1 (2%)
Lumbar, Infiltration Cellular, Diffuse,
Plasma Cell 1 (2%)
Lumbar, Infiltration Cellular, Diffuse,
Polymorphonuclear 1 (2%)
Lumbar, Infiltration Cellular, Focal, Plasma
Cell 1 (9%)
Mandibular, Depletion Lymphoid, Diffuse 4 (9%)
Mandibular, Hematopoietic Cell Proliferation,
Diffuse 1 (2%)
Mandibular, Hyperplasia, Diffuse, Lymphoid 1 (2%) 1 (2%)
Mandibular, Infiltration Cellular, Diffuse,
Plasma Cell 3 (6%) 1 (2%)
Mediastinal, Depletion Lymphoid, Diffuse 1 (2%)
Mesenteric, Angiectasis, Diffuse 10 (21%) 4 (36%) 3 (6%)
Mesenteric, Angiectasis, Multifocal 1 (2%) 1 (9%) 1 (2%)
Mesenteric, Erythrophagocytosis, Diffuse 1 (2%)
Mesenteric, Hematopoietic Cell Proliferation,
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05052-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 23:47:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Diffuse 5 (10%) 1 (9%)
Mesenteric, Inflammation, Chronic 1 (2%)
Pancreatic, Angiectasis, Diffuse 1 (2%)
Pancreatic, Angiectasis, Multifocal 2 (18%)
Pancreatic, Hematopoietic Cell Proliferation,
Diffuse 2 (18%)
Pancreatic, Inflammation, Acute, Diffuse 1 (2%)
Spleen (49) (46) (47)
Inflammation, Acute, Multifocal 1 (2%)
Capsule, Fibrosis, Focal 1 (2%)
Lymphoid Follicle, Depletion Lymphoid,
Multifocal 1 (2%) 4 (9%) 10 (21%)
Lymphoid Follicle, Hyperplasia, Diffuse 1 (2%)
Lymphoid Follicle, Hyperplasia, Diffuse,
Lymphoid 1 (2%)
Lymphoid Follicle, Hyperplasia, Focal,
Lymphoid 1 (2%)
Lymphoid Follicle, Necrosis, Acute,
Multifocal 1 (2%)
Red Pulp, Angiectasis, Multifocal 1 (2%)
Red Pulp, Hematopoietic Cell Proliferation,
Diffuse 10 (20%) 11 (24%) 3 (6%)
Red Pulp, Infiltration Cellular, Focal,
Plasma Cell 1 (2%)
Thymus (38) (38)
Depletion Lymphoid, Diffuse 3 (8%) 2 (5%)
Cortex, Cyst, Single 1 (3%)
Medulla, Cyst, Multiple 1 (3%)
Thymocyte, Necrosis, Acute, Diffuse 1 (3%) 8 (21%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (21) (49)
Acanthosis, Diffuse 1 (2%)
Acanthosis, Focal 1 (2%)
Hyperkeratosis, Diffuse 1 (2%)
Inflammation, Acute, Focal 1 (2%)
Inflammation, Focal, Subacute 1 (2%)
Necrosis, Acute, Diffuse 1 (2%)
Abdominal, Inflammation, Chronic, Focal 1 (2%)
Abdominal, Ulcer, Acute, Focal 1 (2%)
Abdominal, Ulcer, Acute, Multifocal 2 (4%)
Back, Acanthosis, Focal 2 (4%)
Back, Alopecia, Focal 1 (5%)
Back, Fibrosis, Diffuse 2 (4%)
Back, Fibrosis, Focal 1 (2%) 5 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05052-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 23:47:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Back, Fibrosis, Multifocal 1 (2%)
Back, Hyperplasia, Diffuse,
Pseudoepitheliomatous 1 (2%)
Back, Inflammation, Chronic, Diffuse 1 (2%)
Back, Inflammation, Chronic Active, Diffuse 1 (2%)
Back, Ulcer, Acute, Diffuse 1 (2%)
Back, Ulcer, Acute, Focal 3 (6%) 2 (4%)
Back, Ulcer, Acute, Multifocal 1 (2%)
Back, Ulcer, Chronic Active, Focal 1 (2%)
Back, Ulcer, Chronic Active, Multifocal 2 (4%) 1 (2%)
Dermis, Fibrosis, Focal 1 (2%)
Dermis, Inflammation, Focal, Subacute 1 (2%)
Face, Ulcer, Chronic Active, Multifocal 1 (2%)
Face, Subcutaneous Tissue, Granuloma, Focal 1 (2%)
Face, Subcutaneous Tissue, Inflammation,
Chronic Active, Focal 1 (2%)
Hindlimb, Subcutaneous Tissue, Inflammation,
Chronic, Focal, Granulomatous 1 (2%)
Neck, Subcutaneous Tissue, Inflammation,
Acute, Focal 1 (2%)
Prepuce, Inflammation, Acute, Focal 1 (5%)
Prepuce, Inflammation, Acute, Focal,
Necrotizing 2 (10%)
Prepuce, Inflammation, Acute, Multifocal 1 (2%)
Prepuce, Inflammation, Acute, Multifocal,
Necrotizing 1 (5%)
Prepuce, Inflammation, Chronic, Focal,
Necrotizing 1 (5%) 1 (2%)
Prepuce, Inflammation, Chronic Active, Focal 1 (2%)
Prepuce, Inflammation, Focal, Granulomatous,
Necrotizing 2 (10%)
Prepuce, Ulcer, Acute, Focal 1 (2%)
Right, Inflammation, Chronic Active, Focal 1 (2%)
Subcutaneous Tissue, Granuloma, Focal 1 (2%)
Subcutaneous Tissue, Granuloma, Multiple 1 (2%)
Subcutaneous Tissue, Inflammation, Acute,
Diffuse 1 (2%)
Subcutaneous Tissue, Inflammation, Acute,
Focal 1 (2%) 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic,
Diffuse 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic,
Focal 1 (2%)
Subcutaneous Tissue, Inflammation, Focal,
Granulomatous 1 (2%) 3 (6%)
Thoracic, Fibrosis, Focal 1 (2%)
Thoracic, Inflammation, Chronic Active,
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05052-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 23:47:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Diffuse 1 (5%)
Thoracic, Inflammation, Chronic Active, Focal 1 (2%)
Thoracic, Ulcer, Chronic Active, Multifocal 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (39) (50)
Hyperostosis 1 (3%) 1 (2%)
Bilateral, Joint, Tarsal, Arthrosis, Chronic 31 (62%) 33 (85%) 18 (36%)
Bilateral, Joint, Tarsal, Metaplasia,
Diffuse, Osseous 1 (3%)
Bilateral, Joint, Tarsal, Metaplasia,
Multifocal, Osseous 1 (2%)
Joint, Right, Tarsal, Inflammation, Chronic
Active, Diffuse 1 (2%)
Joint, Left, Tarsal, Metaplasia, Multifocal,
Osseous 1 (2%)
Joint, Tarsal, Arthrosis, Chronic 1 (3%)
Joint, Phalanges, Inflammation, Chronic
Active, Focal 1 (3%)
Unilateral, Joint, Tarsal, Arthrosis, Chronic 9 (18%) 1 (3%) 11 (22%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (1) (50)
Hemorrhage, Acute, Multifocal 1 (100%)
Cerebellum, Perivascular Cuffing, Focal 1 (2%)
Cerebrum, Inflammation, Acute, Focal 1 (2%)
Fourth Ventricle, Lateral Ventricle,
Hydrocephalus 1 (2%)
Lateral Ventricle, Hydrocephalus 1 (2%)
Meninges, Perivascular Cuffing, Focal 1 (2%)
Meninges, Perivascular Cuffing, Multifocal 1 (2%)
Thalamus, Mineralization 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (4) (50)
Edema, Multifocal, Subacute 1 (2%)
Foreign Body, Multifocal 5 (10%)
Hemorrhage, Diffuse, Subacute 1 (2%)
Infarct, Acute, Multifocal 1 (25%)
Infiltration Cellular, Diffuse, Histiocyte 1 (2%)
Infiltration Cellular, Focal, Histiocyte 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05052-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 23:47:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation, Acute, Multifocal 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 6 (12%) 3 (6%)
Capillary, Infiltration Cellular, Acute,
Diffuse, Polymorphonuclear 1 (2%)
Capillary, Infiltration Cellular, Diffuse,
Polymorphonuclear 1 (2%)
Diaphragmatic Lobe, Right, Edema, Focal,
Subacute 1 (2%)
Interstitium, Infiltration Cellular, Acute,
Diffuse, Polymorphonuclear 1 (2%)
Interstitium, Inflammation, Acute, Diffuse 1 (2%)
Interstitium, Inflammation, Acute, Multifocal 1 (2%)
Interstitium, Inflammation, Multifocal,
Subacute 1 (2%)
Mediastinum, Infiltration Cellular,
Multifocal, Lymphocyte 1 (2%)
Peribronchial, Infiltration Cellular,
Multifocal, Lymphocyte 1 (2%)
Right, Edema, Chronic, Diffuse 1 (2%)
Nose (43) (34)
Mucosa, Inflammation, Acute 1 (2%)
Mucosa, Inflammation, Acute, Multifocal 2 (5%)
Nasolacrimal Duct, Inflammation, Acute,
Multifocal 1 (2%)
Septum, Inflammation, Acute, Focal 1 (3%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1)
Atrophy 1 (100%)
Harderian Gland (44) (3) (30)
Hyperplasia, Focal 1 (33%)
Bilateral, Hyperplasia, Multifocal 1 (3%)
Right, Hyperplasia, Focal 1 (3%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (6) (49)
Inflammation, Acute, Multifocal 2 (4%)
Inflammation, Chronic, Focal 1 (2%)
Inflammation, Multifocal, Subacute 1 (17%)
Bilateral, Infarct, Acute, Multifocal 1 (17%)
Bilateral, Inflammation, Acute, Multifocal,
Suppurative 1 (17%) 1 (2%)
Bilateral, Inflammation, Chronic, Multifocal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05052-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 23:47:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Cortex, Cyst, Focal 1 (2%)
Cortex, Infarct, Chronic, Focal 1 (2%)
Cortex, Inflammation, Acute, Focal 1 (2%)
Cortex, Metaplasia, Focal, Osseous 1 (2%)
Cortex, Renal Tubule, Necrosis, Acute,
Multifocal 1 (2%)
Corticomedullary Junction, Angiectasis,
Multifocal 1 (2%)
Corticomedullary Junction, Metaplasia, Focal,
Osseous 1 (2%)
Corticomedullary Junction, Mineralization,
Multifocal 4 (8%)
Corticomedullary Junction, Thrombosis,
Chronic, Focal 1 (2%)
Corticomedullary Junction, Renal Tubule,
Mineralization, Multifocal 1 (17%)
Left, Inflammation, Chronic Active, Diffuse 1 (2%)
Pelvis, Inflammation, Acute, Diffuse 1 (17%)
Pelvis, Inflammation, Acute, Multifocal,
Suppurative 1 (2%)
Pelvis, Mineralization, Focal 1 (2%)
Renal Tubule, Cytoplasmic Alteration,
Multifocal 1 (2%)
Renal Tubule, Dilatation, Diffuse 2 (33%) 2 (4%)
Renal Tubule, Dilatation, Focal 1 (2%)
Renal Tubule, Necrosis, Acute, Diffuse 1 (17%)
Renal Tubule, Necrosis, Diffuse, Subacute 1 (2%)
Renal Tubule, Regeneration, Focal 3 (6%) 4 (8%)
Renal Tubule, Regeneration, Multifocal 8 (16%) 4 (8%)
Right, Atrophy 1 (17%)
Right, Inflammation, Chronic Active, Diffuse 1 (17%)
Urethra (2)
Concretion, Focal 2 (100%)
Transitional Epithelium, Necrosis, Acute,
Focal 1 (50%)
Urinary Bladder (48) (3) (46)
Calculus Gross Observation 1 (33%)
Lumen, Ectasia 2 (67%)
Mucosa, Necrosis, Focal, Single 1 (2%)
Serosa, Inflammation, Acute, Multifocal 1 (2%)
Submucosa, Inflammation, Acute, Diffuse 1 (2%) 1 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 112867-112867/112867
--multipart-boundary--