TDMS Study 05052-02 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
2,4-DICHLOROPHENOL
NTP Experiment-Test: 05052-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/07/94
Route: DOSED FEED Time: 23:50:15
Facility: Battelle Columbus Laboratory
Chemical CAS #: 120-83-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05052-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 23:50:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Dead 4 10 5
Moribund 1 2
Survivors
Terminal Sacrifice 45 40 43
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (46) (45)
Papilloma 1 (2%)
Intestine Small (48) (2) (47)
Liver (50) (6) (50)
Hepatocellular Carcinoma 2 (4%) 1 (2%)
Hepatocellular Adenoma 2 (33%)
Mesentery (47) (1) (48)
Liposarcoma, Metastatic, Skin 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Pancreas (49) (47)
Salivary Glands (49) (47)
Stomach (49) (14) (48)
Forestomach, Squamous Cell Carcinoma 1 (2%)
Forestomach, Squamous Cell Papilloma 3 (6%) 3 (21%)
Glandular, Hepatocellular Carcinoma,
Metastatic 1 (2%)
Tooth (48) (44)
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CARDIOVASCULAR SYSTEM
Heart (50) (1) (50)
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ENDOCRINE SYSTEM
Adrenal Gland (49) (1) (50)
Sarcoma, Metastatic, Skin 1 (2%)
Medulla, Pheochromocytoma Benign 2 (4%) 2 (4%)
Spindle Cell, Adenoma 1 (2%) 2 (4%)
Islets, Pancreatic (49) (47)
Adenoma 1 (2%)
Pituitary Gland (49) (48)
Page 2
NTP Experiment-Test: 05052-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 23:50:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pars Distalis, Adenocarcinoma 1 (2%)
Pars Distalis, Adenoma 4 (8%) 3 (6%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (49) (47)
Follicular Cell, Adenoma 1 (2%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (48) (22) (48)
Choriocarcinoma 1 (2%)
Cystadenoma 1 (2%)
Granulosa Cell Tumor 1 (5%) 1 (2%)
Uterus (49) (40) (49)
Polyp Stromal 2 (4%) 2 (5%) 1 (2%)
Sarcoma 1 (2%)
Sarcoma Stromal 1 (2%)
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HEMATOPOIETIC SYSTEM
Blood (13) (7)
Bone Marrow (50) (50)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Lymph Node (48) (9) (46)
Sarcoma, Metastatic, Skin 1 (2%)
Spleen (49) (9) (49)
Hemangiosarcoma 1 (2%)
Liposarcoma, Metastatic, Skin 1 (2%)
Thymus (47) (1) (42)
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INTEGUMENTARY SYSTEM
Mammary Gland (19) (1) (29)
Adenocarcinoma 1 (5%)
Basosquamous Tumor Benign 1 (100%)
Skin (48) (1) (49)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Liposarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05052-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 23:50:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (2) (50)
Skeletal Muscle (2) (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (48)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (1) (50)
Adenocarcinoma, Metastatic, Harderian Gland 1 (2%)
Alveolar/Bronchiolar Adenoma 2 (4%) 1 (100%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Liposarcoma, Metastatic, Skin 1 (2%)
Nose (48) (44)
Adenocarcinoma, Metastatic, Harderian Gland 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
Schwannoma Malignant 1 (100%)
Harderian Gland (35) (2) (41)
Adenocarcinoma 1 (2%)
Adenoma 1 (3%) 2 (5%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50)
Urinary Bladder (48) (47)
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SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Lymphoma Malignant Histiocytic 3 (6%)
Lymphoma Malignant Lymphocytic 6 (12%) 3 (6%) 1 (2%)
Lymphoma Malignant Mixed 2 (4%) 3 (6%) 2 (4%)
Lymphoma Malignant Undifferentiated Cell 1 (2%) 1 (2%)
Mesothelioma Benign 1 (2%)
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 05052-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 23:50:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(50) *(50) *(50)
____________________________________________________________________________________________________________________________________
Page 5
NTP Experiment-Test: 05052-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 23:50:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 26 14 22
Total Primary Neoplasms 38 16 28
Total Animals with Benign Neoplasms 16 8 10
Total Benign Neoplasms 19 9 15
Total Animals with Malignant Neoplasms 16 6 12
Total Malignant Neoplasms 19 6 12
Total Animals with Metastatic Neoplasms 3 3
Total Metastatic Neoplasm 3 8
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1
Total Uncertain Neoplasms 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05052-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 23:50:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Dead 12 14 12
Moribund 5 4 3
Drowned 4
Survivors
Terminal Sacrifice 33 32 31
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (42) (40)
Intestine Large (48) (1) (45)
Intestine Small (44) (1) (41)
Liver (50) (49) (48)
Hemangiosarcoma 1 (2%) 1 (2%)
Hemangiosarcoma, Multiple 1 (2%)
Hepatocellular Carcinoma 5 (10%) 7 (14%) 3 (6%)
Hepatocellular Carcinoma, Trabecular,
Multiple 1 (2%)
Hepatocellular Carcinoma, Multiple 1 (2%)
Hepatocellular Adenoma 3 (6%) 5 (10%) 6 (13%)
Hepatocellular Adenoma, Multiple 1 (2%)
Mesentery (21) (1) (37)
Pancreas (49) (45)
Salivary Glands (50) (49)
Stomach (48) (6) (46)
Forestomach, Squamous Cell Carcinoma 1 (2%)
Forestomach, Squamous Cell Papilloma 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (1) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (100%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05052-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 23:50:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (45)
Medulla, Pheochromocytoma Benign 1 (2%)
Spindle Cell, Adenoma 1 (2%) 1 (2%)
Thyroid Gland (50) (48)
Follicular Cell, Adenoma 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
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GENITAL SYSTEM
Epididymis (48) (48)
Penis (5) (4) (2)
Sarcoma 1 (20%)
Preputial Gland (10) (5) (9)
Sarcoma 1 (10%)
Prostate (48) (49) (49)
Testes (48) (1) (48)
Interstitial Cell, Adenoma 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (48) (11) (47)
Sarcoma, Metastatic, Skin 1 (2%)
Spleen (49) (46) (47)
Hemangiosarcoma 1 (2%)
Thymus (38) (38)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (21) (49)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%) 5 (24%) 2 (4%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 5 (24%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma, Multiple 1 (2%)
Subcutaneous Tissue, Leiomyosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 5 (10%) 3 (14%) 1 (2%)
Subcutaneous Tissue, Sarcoma, Multiple 2 (4%) 1 (5%)
Tail, Subcutaneous Tissue, Sarcoma 1 (5%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05052-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 23:50:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
Fibrosarcoma, Metastatic, Skin 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (1) (50)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (4) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 3 (6%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (25%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (25%) 2 (4%)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (25%)
Fibrosarcoma, Metastatic, Skin 1 (25%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (44) (3) (30)
Adenocarcinoma 1 (2%)
Adenoma 2 (5%) 2 (67%) 4 (13%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (6) (49)
Fibrosarcoma, Metastatic, Skin 1 (17%)
Urinary Bladder (48) (3) (46)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Lymphoma Malignant Histiocytic 1 (2%) 2 (4%)
Lymphoma Malignant Lymphocytic 1 (2%) 3 (6%)
Lymphoma Malignant Mixed 2 (4%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 9
NTP Experiment-Test: 05052-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 23:50:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 29 29 24
Total Primary Neoplasms 39 37 33
Total Animals with Benign Neoplasms 11 13 16
Total Benign Neoplasms 13 14 21
Total Animals with Malignant Neoplasms 21 21 10
Total Malignant Neoplasms 26 23 12
Total Animals with Metastatic Neoplasms 1 2
Total Metastatic Neoplasm 1 5
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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