TDMS Study 05052-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus 2,4-DICHLOROPHENOL DATE: 09/08/94
EXPERIMENT: 05052 TEST: 02 TIME: 00:04:30
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-38068 ROUTE: DOSED FEED NTP C#: C55345
PATHOLOGIST: S. EUSTIS G. DILL CAS: 120-83-2
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus 2,4-DICHLOROPHENOL DATE: 09/08/94
EXPERIMENT: 05052 TEST: 02 TIME: 00:04:30
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-38068 ROUTE: DOSED FEED NTP C#: C55345
PATHOLOGIST: S. EUSTIS G. DILL CAS: 120-83-2
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus 2,4-DICHLOROPHENOL DATE: 09/08/94
EXPERIMENT: 05052 TEST: 02 TIME: 00:04:30
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-38068 ROUTE: DOSED FEED NTP C#: C55345
PATHOLOGIST: S. EUSTIS G. DILL CAS: 120-83-2
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF 2,4-DICHLOROPHENOL
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Lung Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Skin: Subcutaneous Tissue Neurofibrosarcoma, Fibrosarcoma, or Sarcoma
Sarcoma
Stomach, Forestomach Squamous Cell Carcinoma or Papilloma Squamous
All Organs Malignant Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Stomach, Forestomach Squamous Cell Carcinoma or Papilloma Squamous
All Organs Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/08/94 EXPERIMENT: 05052 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 5000 PPM 10000 |
| | PPM | PPM |
|=================================================================================================================================|
| |
|Adrenal Gland: Non-medullary, Non-cortical |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 0/0 (0%) 1/45 (2%) | 1/49 (2%) 0/1 (0%) 2/50 (4%) |
|ADJUSTED (b) | 3.0% 0.0% 3.2% | 2.2% 0.0% 4.7% |
|TERMINAL (d) | 1/33 (3%) 0/0 1/31 (3%) | 1/45 (2%) 0/0 2/43 (5%) |
|FIRST INCIDENCE (DAYS) | 727 (T) --- 727 (T) | 728 (T) --- 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.622 (e) P=0.748 | P=0.370 (e) P=0.484 |
|INCIDENTAL TUMOR | P=0.622 (e) P=0.748 | P=0.370 (e) P=0.484 |
|LOGISTIC REGRESSION | P=0.622 (e) P=0.748 | P=0.370 (e) P=0.484 |
|COCHRAN-ARMITAGE | P=0.617 | P=0.391 |
|FISHER EXACT | P=1.000N P=0.731 | P=0.980N P=0.508 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/0 (0%) 1/45 (2%) | 2/49 (4%) 0/1 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 3.2% | 4.4% 0.0% 4.7% |
|TERMINAL (d) | 0/33 (0%) 0/0 1/31 (3%) | 2/45 (4%) 0/0 2/43 (5%) |
|FIRST INCIDENCE (DAYS) | --- --- 727 (T) | 728 (T) --- 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.298 (e) P=0.488 | P=0.582 (e) P=0.678 |
|INCIDENTAL TUMOR | P=0.298 (e) P=0.488 | P=0.582 (e) P=0.678 |
|LOGISTIC REGRESSION | P=0.298 (e) P=0.488 | P=0.582 (e) P=0.678 |
|COCHRAN-ARMITAGE | P=0.293 | P=0.593N |
|FISHER EXACT | (e) P=0.479 | P=0.960N P=0.684N |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05052 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 5000 PPM 10000 |
| | PPM | PPM |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 4/50 (8%) | 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 6.1% 6.3% 12.9% | 2.2% 0.0% 4.7% |
|TERMINAL (d) | 2/33 (6%) 2/32 (6%) 4/31 (13%) | 1/45 (2%) 0/40 (0%) 2/43 (5%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 727 (T) 727 (T) | 728 (T) --- 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.227 P=0.685 P=0.307 | P=0.351 P=0.523N P=0.484 |
|INCIDENTAL TUMOR | P=0.227 P=0.685 P=0.307 | P=0.351 P=0.523N P=0.484 |
|LOGISTIC REGRESSION | P=0.227 P=0.685 P=0.307 | P=0.351 P=0.523N P=0.484 |
|COCHRAN-ARMITAGE | P=0.252 | P=0.360 |
|FISHER EXACT | P=0.691N P=0.339 | P=0.500N P=0.500 |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 2/50 (4%) 4/50 (8%) | 1/50 (2%) 0/50 (0%) 3/50 (6%) |
|ADJUSTED (b) | 9.1% 6.3% 12.9% | 2.2% 0.0% 6.8% |
|TERMINAL (d) | 3/33 (9%) 2/32 (6%) 4/31 (13%) | 1/45 (2%) 0/40 (0%) 2/43 (5%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 727 (T) 727 (T) | 728 (T) --- 697 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.385 P=0.514N P=0.465 | P=0.173 P=0.523N P=0.293 |
|INCIDENTAL TUMOR | P=0.385 P=0.514N P=0.465 | P=0.124 P=0.523N P=0.207 |
|LOGISTIC REGRESSION | P=0.385 P=0.514N P=0.465 | P=0.166 P=0.523N P=0.287 |
|COCHRAN-ARMITAGE | P=0.417 | P=0.176 |
|FISHER EXACT | P=0.500N P=0.500 | P=0.500N P=0.309 |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05052 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 5000 PPM 10000 |
| | PPM | PPM |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/49 (4%) 0/48 (0%) | 0/50 (0%) 0/6 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.5% 5.2% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/33 (0%) 1/32 (3%) 0/31 (0%) | 0/45 (0%) 0/5 (0%) 0/43 (0%) |
|FIRST INCIDENCE (DAYS) | 682 476 --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.410N P=0.476 P=0.551N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.260N P=0.745 P=0.814N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.351N P=0.490 P=0.526N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.371N | (e) |
|FISHER EXACT | P=0.492 P=0.510N | (e) (e) |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 5/49 (10%) 6/48 (13%) | 0/50 (0%) 2/6 (33%) 0/50 (0%) |
|ADJUSTED (b) | 12.1% 15.6% 19.4% | 0.0% 40.0% 0.0% |
|TERMINAL (d) | 4/33 (12%) 5/32 (16%) 6/31 (19%) | 0/45 (0%) 2/5 (40%) 0/43 (0%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 727 (T) 727 (T) | --- 728 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.267 P=0.480 P=0.327 | P=0.631 P<0.001 ** (e) |
|INCIDENTAL TUMOR | P=0.267 P=0.480 P=0.327 | P=0.631 P<0.001 ** (e) |
|LOGISTIC REGRESSION | P=0.267 P=0.480 P=0.327 | P=0.631 P<0.001 ** (e) |
|COCHRAN-ARMITAGE | P=0.285 | P=0.643 |
|FISHER EXACT | P=0.487 P=0.344 | P=0.010 ** (e) |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05052 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 5000 PPM 10000 |
| | PPM | PPM |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 7/49 (14%) 3/48 (6%) | 2/50 (4%) 0/6 (0%) 1/50 (2%) |
|ADJUSTED (b) | 18.6% 18.7% 9.4% | 4.4% 0.0% 2.3% |
|TERMINAL (d) | 4/33 (12%) 3/32 (9%) 2/31 (6%) | 2/45 (4%) 0/5 (0%) 1/43 (2%) |
|FIRST INCIDENCE (DAYS) | 605 665 675 | 728 (T) --- 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.203N P=0.567 P=0.222N | P=0.397N P=0.763N P=0.516N |
|INCIDENTAL TUMOR | P=0.457N P=0.517 P=0.445N | P=0.397N P=0.763N P=0.516N |
|LOGISTIC REGRESSION | P=0.401N P=0.567 P=0.242N | P=0.397N P=0.763N P=0.516N |
|COCHRAN-ARMITAGE | P=0.151N | P=0.382N |
|FISHER EXACT | P=0.597 P=0.176N | P=0.795N P=0.500N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 12/49 (24%) 9/48 (19%) | 2/50 (4%) 2/6 (33%) 1/50 (2%) |
|ADJUSTED (b) | 27.0% 32.7% 28.1% | 4.4% 40.0% 2.3% |
|TERMINAL (d) | 7/33 (21%) 8/32 (25%) 8/31 (26%) | 2/45 (4%) 2/5 (40%) 1/43 (2%) |
|FIRST INCIDENCE (DAYS) | 605 665 675 | 728 (T) 728 (T) 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.541 P=0.364 P=0.592N | P=0.427N P=0.029 * P=0.516N |
|INCIDENTAL TUMOR | P=0.302 P=0.315 P=0.405 | P=0.427N P=0.029 * P=0.516N |
|LOGISTIC REGRESSION | P=0.430 P=0.352 P=0.494 | P=0.427N P=0.029 * P=0.516N |
|COCHRAN-ARMITAGE | P=0.492N | P=0.407N |
|FISHER EXACT | P=0.384 P=0.540N | P=0.053 P=0.500N |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05052 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 5000 PPM 10000 |
| | PPM | PPM |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 12/49 (24%) 9/48 (19%) | 2/50 (4%) 2/6 (33%) 1/50 (2%) |
|ADJUSTED (b) | 27.0% 32.7% 28.1% | 4.4% 40.0% 2.3% |
|TERMINAL (d) | 7/33 (21%) 8/32 (25%) 8/31 (26%) | 2/45 (4%) 2/5 (40%) 1/43 (2%) |
|FIRST INCIDENCE (DAYS) | 605 665 675 | 728 (T) 728 (T) 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.541 P=0.364 P=0.592N | P=0.427N P=0.029 * P=0.516N |
|INCIDENTAL TUMOR | P=0.302 P=0.315 P=0.405 | P=0.427N P=0.029 * P=0.516N |
|LOGISTIC REGRESSION | P=0.430 P=0.352 P=0.494 | P=0.427N P=0.029 * P=0.516N |
|COCHRAN-ARMITAGE | P=0.492N | P=0.407N |
|FISHER EXACT | P=0.384 P=0.540N | P=0.053 P=0.500N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/4 (25%) 3/50 (6%) | 2/50 (4%) 1/1 (100%) 2/50 (4%) |
|ADJUSTED (b) | 6.1% 100.0% 9.7% | 4.4% 100.0% 4.7% |
|TERMINAL (d) | 2/33 (6%) 1/1 (100%) 3/31 (10%) | 2/45 (4%) 1/1 (100%) 2/43 (5%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 727 (T) 727 (T) | 728 (T) 728 (T) 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.385 P=0.073 P=0.471 | P=0.571 P=0.039 * P=0.678 |
|INCIDENTAL TUMOR | P=0.385 P=0.073 P=0.471 | P=0.571 P=0.039 * P=0.678 |
|LOGISTIC REGRESSION | P=0.385 P=0.073 P=0.471 | P=0.571 P=0.039 * P=0.678 |
|COCHRAN-ARMITAGE | P=0.415 | P=0.591 |
|FISHER EXACT | P=0.210 P=0.500 | P=0.059 P=0.691N |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05052 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 5000 PPM 10000 |
| | PPM | PPM |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/4 (25%) 2/50 (4%) | 1/50 (2%) 0/1 (0%) 0/50 (0%) |
|ADJUSTED (b) | 3.0% 2.8% 6.5% | 2.1% 0.0% 0.0% |
|TERMINAL (d) | 1/33 (3%) 0/1 (0%) 2/31 (6%) | 0/45 (0%) 0/1 (0%) 0/43 (0%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 681 727 (T) | 668 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.359 P=0.502 P=0.478 | P=0.285N P=0.527N P=0.517N |
|INCIDENTAL TUMOR | P=0.286 P=0.229 P=0.478 | P=0.500N (e) P=0.718N |
|LOGISTIC REGRESSION | P=0.324 P=0.148 P=0.478 | P=0.267N (e) P=0.465N |
|COCHRAN-ARMITAGE | P=0.397 | P=0.307N |
|FISHER EXACT | P=0.144 P=0.500 | P=0.980N P=0.500N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 2/4 (50%) 5/50 (10%) | 3/50 (6%) 1/1 (100%) 2/50 (4%) |
|ADJUSTED (b) | 9.1% 100.0% 16.1% | 6.4% 100.0% 4.7% |
|TERMINAL (d) | 3/33 (9%) 1/1 (100%) 5/31 (16%) | 2/45 (4%) 1/1 (100%) 2/43 (5%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 681 727 (T) | 668 728 (T) 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.260 P=0.063 P=0.320 | P=0.439N P=0.523 P=0.524N |
|INCIDENTAL TUMOR | P=0.219 P=0.007 ** P=0.320 | P=0.519N P=0.039 * P=0.608N |
|LOGISTIC REGRESSION | P=0.207 P=0.009 ** P=0.320 | P=0.437N P=0.051 P=0.516N |
|COCHRAN-ARMITAGE | P=0.305 | P=0.416N |
|FISHER EXACT | P=0.039 * P=0.357 | P=0.078 P=0.500N |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05052 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 5000 PPM 10000 |
| | PPM | PPM |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/45 (0%) 0/0 (0%) 0/47 (0%) | 4/49 (8%) 0/0 (0%) 3/48 (6%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 8.9% 0.0% 7.0% |
|TERMINAL (d) | 0/29 (0%) 0/0 0/30 (0%) | 4/45 (9%) 0/0 3/43 (7%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 728 (T) --- 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.447N (e) P=0.525N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.447N (e) P=0.525N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.447N (e) P=0.525N |
|COCHRAN-ARMITAGE | (e) | P=0.433N |
|FISHER EXACT | (e) (e) | P=1.000N P=0.512N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/45 (0%) 0/0 (0%) 0/47 (0%) | 4/49 (8%) 0/0 (0%) 4/48 (8%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 8.9% 0.0% 9.3% |
|TERMINAL (d) | 0/29 (0%) 0/0 0/30 (0%) | 4/45 (9%) 0/0 4/43 (9%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 728 (T) --- 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.547 (e) P=0.619 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.547 (e) P=0.619 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.547 (e) P=0.619 |
|COCHRAN-ARMITAGE | (e) | P=0.561 |
|FISHER EXACT | (e) (e) | P=1.000N P=0.631 |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05052 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 5000 PPM 10000 |
| | PPM | PPM |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 5/50 (10%) 3/50 (6%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 6.1% 15.6% 9.7% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/33 (6%) 5/32 (16%) 3/31 (10%) | 0/45 (0%) 0/40 (0%) 0/43 (0%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 727 (T) 727 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.387 P=0.201 P=0.471 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.387 P=0.201 P=0.471 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.387 P=0.201 P=0.471 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.421 | (e) |
|FISHER EXACT | P=0.218 P=0.500 | (e) (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 5/50 (10%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.6% 13.3% 3.2% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/33 (0%) 2/32 (6%) 1/31 (3%) | 0/45 (0%) 0/40 (0%) 0/43 (0%) |
|FIRST INCIDENCE (DAYS) | 687 510 727 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.535 P=0.099 P=0.731 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.532 P=0.154 P=0.629 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.562 P=0.103 P=0.724 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.594 | (e) |
|FISHER EXACT | P=0.102 P=0.753N | (e) (e) |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05052 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 5000 PPM 10000 |
| | PPM | PPM |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 14/50 (28%) 5/50 (10%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 24.1% 36.1% 16.1% | 0.0% 0.0% 2.1% |
|TERMINAL (d) | 3/33 (9%) 8/32 (25%) 5/31 (16%) | 0/45 (0%) 0/40 (0%) 0/43 (0%) |
|FIRST INCIDENCE (DAYS) | 651 510 727 (T) | --- --- 549 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.215N P=0.220 P=0.211N | P=0.263 (e) P=0.488 |
|INCIDENTAL TUMOR | P=0.389N P=0.206 P=0.502N | P=0.315 (e) P=0.581 |
|LOGISTIC REGRESSION | P=0.209N P=0.221 P=0.219N | P=0.350 (e) P=0.669 |
|COCHRAN-ARMITAGE | P=0.127N | P=0.269 |
|FISHER EXACT | P=0.241 P=0.131N | (e) P=0.500 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 8/50 (16%) 10/50 (20%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 19.1% 25.5% 6.5% | 0.0% 0.0% 2.1% |
|TERMINAL (d) | 1/33 (3%) 4/32 (13%) 2/31 (6%) | 0/45 (0%) 0/40 (0%) 0/43 (0%) |
|FIRST INCIDENCE (DAYS) | 651 510 727 (T) | --- --- 549 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.106N P=0.356 P=0.092N | P=0.263 (e) P=0.488 |
|INCIDENTAL TUMOR | P=0.221N P=0.368 P=0.312N | P=0.315 (e) P=0.581 |
|LOGISTIC REGRESSION | P=0.172N P=0.261 P=0.071N | P=0.350 (e) P=0.669 |
|COCHRAN-ARMITAGE | P=0.053N | P=0.269 |
|FISHER EXACT | P=0.398 P=0.046N* | (e) P=0.500 |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05052 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 5000 PPM 10000 |
| | PPM | PPM |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 5/50 (10%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 16.9% 13.7% 3.2% | 0.0% 0.0% 2.1% |
|TERMINAL (d) | 1/33 (3%) 2/32 (6%) 1/31 (3%) | 0/45 (0%) 0/40 (0%) 0/43 (0%) |
|FIRST INCIDENCE (DAYS) | 651 547 727 (T) | --- --- 549 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.050N* P=0.432N P=0.063N | P=0.263 (e) P=0.488 |
|INCIDENTAL TUMOR | P=0.147N P=0.486N P=0.209N | P=0.315 (e) P=0.581 |
|LOGISTIC REGRESSION | P=0.034N* P=0.483N P=0.115N | P=0.350 (e) P=0.669 |
|COCHRAN-ARMITAGE | P=0.025N* | P=0.269 |
|FISHER EXACT | P=0.380N P=0.030N* | (e) P=0.500 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 3/50 (6%) | 4/50 (8%) 3/50 (6%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 9.7% | 8.9% 7.5% 0.0% |
|TERMINAL (d) | 0/33 (0%) 0/32 (0%) 3/31 (10%) | 4/45 (9%) 3/40 (8%) 0/43 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 727 (T) | 728 (T) 728 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.033 * (e) P=0.110 | P=0.057N P=0.564N P=0.069N |
|INCIDENTAL TUMOR | P=0.033 * (e) P=0.110 | P=0.057N P=0.564N P=0.069N |
|LOGISTIC REGRESSION | P=0.033 * (e) P=0.110 | P=0.057N P=0.564N P=0.069N |
|COCHRAN-ARMITAGE | P=0.037 * | P=0.049N* |
|FISHER EXACT | (e) P=0.121 | P=0.500N P=0.059N |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05052 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 5000 PPM 10000 |
| | PPM | PPM |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) | 3/50 (6%) 3/50 (6%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 6.5% | 6.7% 7.5% 0.0% |
|TERMINAL (d) | 0/33 (0%) 0/32 (0%) 2/31 (6%) | 3/45 (7%) 3/40 (8%) 0/43 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 727 (T) | 728 (T) 728 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.090 (e) P=0.224 | P=0.113N P=0.608 P=0.130N |
|INCIDENTAL TUMOR | P=0.090 (e) P=0.224 | P=0.113N P=0.608 P=0.130N |
|LOGISTIC REGRESSION | P=0.090 (e) P=0.224 | P=0.113N P=0.608 P=0.130N |
|COCHRAN-ARMITAGE | P=0.095 | P=0.101N |
|FISHER EXACT | (e) P=0.247 | P=0.661N P=0.121N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/0 (0%) 0/48 (0%) | 1/49 (2%) 0/0 (0%) 0/47 (0%) |
|ADJUSTED (b) | 6.1% 0.0% 0.0% | 2.2% 0.0% 0.0% |
|TERMINAL (d) | 2/33 (6%) 0/0 0/31 (0%) | 1/45 (2%) 0/0 0/43 (0%) |
|FIRST INCIDENCE (DAYS) | 727 (T) --- --- | 728 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.153N (e) P=0.252N | P=0.317N (e) P=0.509N |
|INCIDENTAL TUMOR | P=0.153N (e) P=0.252N | P=0.317N (e) P=0.509N |
|LOGISTIC REGRESSION | P=0.153N (e) P=0.252N | P=0.317N (e) P=0.509N |
|COCHRAN-ARMITAGE | P=0.149N | P=0.315N |
|FISHER EXACT | P=1.000N P=0.258N | P=1.000N P=0.510N |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05052 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 5000 PPM 10000 |
| | PPM | PPM |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 2/50 (4%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | | 4.4% 5.0% 2.3% |
|TERMINAL (d) | | 2/45 (4%) 2/40 (5%) 1/43 (2%) |
|FIRST INCIDENCE (DAYS) | | 728 (T) 728 (T) 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.409N P=0.652 P=0.516N |
|INCIDENTAL TUMOR | | P=0.409N P=0.652 P=0.516N |
|LOGISTIC REGRESSION | | P=0.409N P=0.652 P=0.516N |
|COCHRAN-ARMITAGE | | P=0.390N |
|FISHER EXACT | | P=0.691N P=0.500N |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 2/50 (4%) 2/50 (4%) 2/50 (4%) |
|ADJUSTED (b) | | 4.4% 5.0% 4.7% |
|TERMINAL (d) | | 2/45 (4%) 2/40 (5%) 2/43 (5%) |
|FIRST INCIDENCE (DAYS) | | 728 (T) 728 (T) 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.581 P=0.652 P=0.678 |
|INCIDENTAL TUMOR | | P=0.581 P=0.652 P=0.678 |
|LOGISTIC REGRESSION | | P=0.581 P=0.652 P=0.678 |
|COCHRAN-ARMITAGE | | P=0.601 |
|FISHER EXACT | | P=0.691N P=0.691N |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05052 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 5000 PPM 10000 |
| | PPM | PPM |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.5% 5.2% 0.0% | 2.2% 0.0% 0.0% |
|TERMINAL (d) | 0/33 (0%) 1/32 (3%) 0/31 (0%) | 1/45 (2%) 0/40 (0%) 0/43 (0%) |
|FIRST INCIDENCE (DAYS) | 682 476 --- | 728 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.410N P=0.476 P=0.551N | P=0.280N P=0.523N P=0.509N |
|INCIDENTAL TUMOR | P=0.240N P=0.745 P=0.739N | P=0.280N P=0.523N P=0.509N |
|LOGISTIC REGRESSION | P=0.343N P=0.509 P=0.519N | P=0.280N P=0.523N P=0.509N |
|COCHRAN-ARMITAGE | P=0.360N | P=0.269N |
|FISHER EXACT | P=0.500 P=0.500N | P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.5% 5.2% 0.0% | 2.2% 0.0% 0.0% |
|TERMINAL (d) | 0/33 (0%) 1/32 (3%) 0/31 (0%) | 1/45 (2%) 0/40 (0%) 0/43 (0%) |
|FIRST INCIDENCE (DAYS) | 682 476 --- | 728 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.410N P=0.476 P=0.551N | P=0.280N P=0.523N P=0.509N |
|INCIDENTAL TUMOR | P=0.240N P=0.745 P=0.739N | P=0.280N P=0.523N P=0.509N |
|LOGISTIC REGRESSION | P=0.343N P=0.509 P=0.519N | P=0.280N P=0.523N P=0.509N |
|COCHRAN-ARMITAGE | P=0.360N | P=0.269N |
|FISHER EXACT | P=0.500 P=0.500N | P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05052 TEST: 02 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 5000 PPM 10000 |
| | PPM | PPM |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 3/50 (6%) 4/50 (8%) | 12/50 (24%) 6/50 (12%) 4/50 (8%) |
|ADJUSTED (b) | 7.2% 8.2% 11.1% | 26.1% 14.1% 9.3% |
|TERMINAL (d) | 1/33 (3%) 2/32 (6%) 2/31 (6%) | 11/45 (24%) 4/40 (10%) 4/43 (9%) |
|FIRST INCIDENCE (DAYS) | 575 469 394 | 679 616 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.354 P=0.637 P=0.423 | P=0.025N* P=0.156N P=0.036N* |
|INCIDENTAL TUMOR | P=0.452 P=0.669N P=0.429 | P=0.029N* P=0.133N P=0.046N* |
|LOGISTIC REGRESSION | P=0.456 P=0.653N P=0.539 | P=0.022N* P=0.118N P=0.036N* |
|COCHRAN-ARMITAGE | P=0.421 | P=0.017N* |
|FISHER EXACT | P=0.661N P=0.500 | P=0.096N P=0.027N* |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 3/50 (6%) 4/50 (8%) | 12/50 (24%) 6/50 (12%) 4/50 (8%) |
|ADJUSTED (b) | 7.2% 8.2% 11.1% | 26.1% 14.1% 9.3% |
|TERMINAL (d) | 1/33 (3%) 2/32 (6%) 2/31 (6%) | 11/45 (24%) 4/40 (10%) 4/43 (9%) |
|FIRST INCIDENCE (DAYS) | 575 469 394 | 679 616 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.354 P=0.637 P=0.423 | P=0.025N* P=0.156N P=0.036N* |
|INCIDENTAL TUMOR | P=0.452 P=0.669N P=0.429 | P=0.029N* P=0.133N P=0.046N* |
|LOGISTIC REGRESSION | P=0.456 P=0.653N P=0.539 | P=0.022N* P=0.118N P=0.036N* |
|COCHRAN-ARMITAGE | P=0.421 | P=0.017N* |
|FISHER EXACT | P=0.661N P=0.500 | P=0.096N P=0.027N* |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05052 TEST: 02 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 5000 PPM 10000 |
| | PPM | PPM |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 11/50 (22%) 13/50 (26%) 16/50 (32%) | 16/50 (32%) 8/50 (16%) 10/50 (20%) |
|ADJUSTED (b) | 33.3% 40.6% 51.6% | 35.6% 20.0% 23.3% |
|TERMINAL (d) | 11/33 (33%) 13/32 (41%) 16/31 (52%) | 16/45 (36%) 8/40 (20%) 10/43 (23%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 727 (T) 727 (T) | 728 (T) 728 (T) 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.089 P=0.363 P=0.112 | P=0.116N P=0.090N P=0.153N |
|INCIDENTAL TUMOR | P=0.089 P=0.363 P=0.112 | P=0.116N P=0.090N P=0.153N |
|LOGISTIC REGRESSION | P=0.089 P=0.363 P=0.112 | P=0.116N P=0.090N P=0.153N |
|COCHRAN-ARMITAGE | P=0.154 | P=0.094N |
|FISHER EXACT | P=0.408 P=0.184 | P=0.050N P=0.127N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 21/50 (42%) 21/50 (42%) 10/50 (20%) | 16/50 (32%) 6/50 (12%) 12/50 (24%) |
|ADJUSTED (b) | 45.1% 47.4% 28.7% | 34.0% 14.1% 25.0% |
|TERMINAL (d) | 8/33 (24%) 9/32 (28%) 7/31 (23%) | 14/45 (31%) 4/40 (10%) 7/43 (16%) |
|FIRST INCIDENCE (DAYS) | 561 469 394 | 668 616 445 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.073N P=0.487 P=0.069N | P=0.255N P=0.035N* P=0.314N |
|INCIDENTAL TUMOR | P=0.108N P=0.570 P=0.217N | P=0.252N P=0.024N* P=0.270N |
|LOGISTIC REGRESSION | P=0.069N P=0.515 P=0.077N | P=0.187N P=0.020N* P=0.215N |
|COCHRAN-ARMITAGE | P=0.014N* | P=0.202N |
|FISHER EXACT | P=0.580N P=0.015N* | P=0.014N* P=0.252N |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05052 TEST: 02 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 5000 PPM 10000 |
| | PPM | PPM |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 29/50 (58%) 29/50 (58%) 24/50 (48%) | 26/50 (52%) 14/50 (28%) 22/50 (44%) |
|ADJUSTED (b) | 62.7% 65.7% 70.3% | 55.3% 33.2% 45.8% |
|TERMINAL (d) | 16/33 (48%) 17/32 (53%) 21/31 (68%) | 24/45 (53%) 12/40 (30%) 17/43 (40%) |
|FIRST INCIDENCE (DAYS) | 561 469 394 | 668 616 445 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.407N P=0.472 P=0.423N | P=0.316N P=0.041N* P=0.364N |
|INCIDENTAL TUMOR | P=0.439 P=0.541 P=0.350 | P=0.321N P=0.031N* P=0.330N |
|LOGISTIC REGRESSION | P=0.477 P=0.487 P=0.517N | P=0.283N P=0.025N* P=0.298N |
|COCHRAN-ARMITAGE | P=0.183N | P=0.239N |
|FISHER EXACT | P=0.580N P=0.212N | P=0.012N* P=0.274N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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