TDMS Study 05052-02 Pathology Tables
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
Facility: Battelle Columbus Laboratory
Chemical CAS #: 120-83-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 8| 8| 8| 8| 8| 7| 9| 9| 9| 9| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | I + + + + + + + + + + M + + + + + + + M + + + + +|
Mucosa, Cyst | X|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + M + + + + + + + + + + + + +|
Ileum, Peyer's Patch, Inflammation, | |
Acute, Focal | |
Jejunum, Peyer's Patch, Hyperplasia, | |
Lymphoid, Multifocal | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X |
Basophilic Focus, Single | X X|
Hematopoietic Cell Proliferation, | |
Multifocal | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Inflammation, Multifocal, Subacute | 1 |
Hepatocyte, Hyperplasia, Focal | |
Hepatocyte, Inflammation, Acute, | |
Focal | |
Hepatocyte, Inflammation, Multifocal,| |
Necrotizing, Subacute | 2 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | 2 |
Kupffer Cell, Pigmentation, | |
Multifocal | |
Left Lateral Lobe, Angiectasis, Focal| 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Multifocal, Subacute | 2 |
Thrombosis | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + A + + + + + + + + + + + + +|
Cyst, Multifocal | |
Acinus, Atrophy, Diffuse | |
Acinus, Atrophy, Focal | 2 |
Acinus, Atrophy, Multifocal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + A + + + + + + + + + + + + +|
Forestomach, Erosion, Focal | |
Forestomach, Epithelium, Hyperplasia,| |
Focal | 4 2 4 4 4 4 |
Mucosa, Glandular, Mineralization, | |
Diffuse | 3 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 8| 8| 8| 8| 8| 7| 9| 9| 9| 9| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Peridontal Tissue, Inflammation, | |
Acute, Focal | 3 |
Peridontal Tissue, Inflammation, | |
Focal, Granulomatous | |
Peridontal Tissue, Inflammation, | |
Focal, Necrotizing | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Mineralization, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + A + + + + + + + + + + + + +|
Cortex, Focal Cellular Change | 2 2 |
Cortex, Hyperplasia, Focal | 2 1 |
Medulla, Hyperplasia, Focal | 3 2 |
Medulla, Hypertrophy | |
Spindle Cell, Hyperplasia, Diffuse | 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2|
Spindle Cell, Hyperplasia, Multifocal| 2 |
Subcapsular, Cyst | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + M M + M M M + M + + + + + + + + +|
Cyst | |
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | |
Pars Distalis, Hyperplasia, Focal | 3 2 1 |
Pars Distalis, Hyperplasia, | |
Multifocal | 2 2 |
Pars Intermedia, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + I + + + + + + + + + + + + +|
Ectopic Tissue | |
Follicle, Cyst, Multiple | X |
Follicular Cell, Hyperplasia, | |
Multifocal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + I + + + + + + + + + A + + + + + + + + + + + + +|
Angiectasis, Diffuse | |
Cyst | X |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 8| 8| 8| 8| 8| 7| 9| 9| 9| 9| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Bilateral, Abscess, Chronic Active, | |
Multifocal | 4 |
Bilateral, Periovarian Tissue, Cyst | X |
Follicle, Cyst | |
Left, Follicle, Cyst | X X |
Periovarian Tissue, Cyst | |
Periovarian Tissue, Right, Cyst | |
Periovarian Tissue, Left, Cyst | X |
Right, Follicle, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + A + + + + + + + + + + + + +|
Endometrium, Angiectasis, Focal | |
Endometrium, Hyperplasia, Cystic, | |
Diffuse, Glandular | 3 3 3 3 4 2 2 3 3 2 3 2 3 3 3 3 3 3 2 3 3 2 3 3|
Endometrium, Metaplasia, Squamous | |
Lumen, Dilatation | |
Lumen, Dilatation, Diffuse | |
Lumen, Dilatation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + M + + + + + + M + + + + + + + + + + + + +|
Bronchial, Hyperplasia, Diffuse, | |
Lymphoid | 3 |
Lumbar, Sinus, Ectasia, Focal | 3 |
Mediastinal, Pigmentation, Diffuse | |
Mesenteric, Angiectasis, Diffuse | 2 2 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + A + + + + + + + + + + + + +|
Lymphoid Follicle, Depletion | |
Lymphoid, Diffuse | 2 2 |
Lymphoid Follicle, Hyperplasia, | |
Diffuse, Lymphoid | 3 |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 3 |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid, Multifocal | 2 |
Red Pulp, Angiectasis, Multifocal | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + A M + + + + + + + + + + + +|
Atrophy, Diffuse | |
Depletion Lymphoid, Diffuse | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 8| 8| 8| 8| 8| 7| 9| 9| 9| 9| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + M + + + M + M + M M M M M M M M + M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + M + + + + + + + + + + + + +|
Face, Subcutaneous Tissue, | |
Inflammation, Focal, | |
Granulomatous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Myelofibrosis, Multifocal | 2 |
Femur, Myelofibrosis, Diffuse | 3 4 |
Femur, Myelofibrosis, Focal | 1 |
Femur, Myelofibrosis, Multifocal | 2 2 2 2 2 2 1 3 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression, Focal | 4 |
Meninges, Infiltration Cellular, | |
Multifocal, Lymphocyte | 2 2 |
Thalamus, Mineralization | 1 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Inflammation, Focal, Granulomatous | 1 |
Inflammation, Focal, Subacute | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 1 1 |
Mediastinum, Infiltration Cellular, | |
Multifocal, Lymphocyte | 3 |
Vein, Intima, Mineralization, Focal | |
__________________________________________________________________________|
Nose | + + + + + M + + + + + + M + + + + + + + + + + + +|
Mucosa, Inflammation, Acute, | |
Multifocal | 2 |
Submucosa, Glands, Ectasia, | |
Multifocal | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + A + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Developmental Malformation | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 8| 8| 8| 8| 8| 7| 9| 9| 9| 9| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + A + + + + + + + + + + + + +|
Capsule, Inflammation, Multifocal, | |
Subacute | 2 |
Cortex, Infarct, Chronic | |
Cortex, Metaplasia, Focal, Osseous | 2 |
Glomerulus, Inflammation, Diffuse, | |
Proliferative | 3 |
Renal Tubule, Casts Protein, Diffuse | 2 |
Renal Tubule, Cytoplasmic Alteration,| |
Diffuse | |
Renal Tubule, Cytoplasmic Alteration,| |
Multifocal | |
Renal Tubule, Degeneration, Diffuse | 3 |
Renal Tubule, Degeneration | |
Renal Tubule, Regeneration, Focal | 2 |
Renal Tubule, Regeneration, | |
Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + A + + +| 46 |
Mucosa, Cyst | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 |
Ileum, Peyer's Patch, Inflammation, | | |
Acute, Focal | 2 | 1 2.0|
Jejunum, Peyer's Patch, Hyperplasia, | | |
Lymphoid, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus, Multiple | | 1 |
Basophilic Focus, Single | | 2 |
Hematopoietic Cell Proliferation, | | |
Multifocal | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
Inflammation, Multifocal, Subacute | | 1 1.0|
Hepatocyte, Hyperplasia, Focal | 2 | 1 2.0|
Hepatocyte, Inflammation, Acute, | | |
Focal | 1 1 | 2 1.0|
Hepatocyte, Inflammation, Multifocal,| | |
Necrotizing, Subacute | | 1 2.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | | 1 2.0|
Kupffer Cell, Pigmentation, | | |
Multifocal | 2 | 1 2.0|
Left Lateral Lobe, Angiectasis, Focal| | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Multifocal, Subacute | | 1 2.0|
Thrombosis | X | 1 |
Fat, Necrosis, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst, Multifocal | 3 | 1 3.0|
Acinus, Atrophy, Diffuse | 4 | 1 4.0|
Acinus, Atrophy, Focal | | 1 2.0|
Acinus, Atrophy, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Forestomach, Erosion, Focal | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Forestomach, Epithelium, Hyperplasia,| | |
Focal | 4 2 4 4 | 10 3.6|
Mucosa, Glandular, Mineralization, | | |
Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Peridontal Tissue, Inflammation, | | |
Acute, Focal | | 1 3.0|
Peridontal Tissue, Inflammation, | | |
Focal, Granulomatous | 3 | 1 3.0|
Peridontal Tissue, Inflammation, | | |
Focal, Necrotizing | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myocardium, Mineralization, | | |
Multifocal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cortex, Focal Cellular Change | 1 | 3 1.7|
Cortex, Hyperplasia, Focal | | 2 1.5|
Medulla, Hyperplasia, Focal | | 2 2.5|
Medulla, Hypertrophy | 1 | 1 1.0|
Spindle Cell, Hyperplasia, Diffuse | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2| 45 2.0|
Spindle Cell, Hyperplasia, Multifocal| | 1 2.0|
Subcapsular, Cyst | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + M + + + + + + + M + + + + + + M + + +| 39 |
Cyst | X | 1 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis, Focal | 2 | 1 2.0|
Pars Distalis, Hyperplasia, Focal | | 3 2.0|
Pars Distalis, Hyperplasia, | | |
Multifocal | 2 | 3 2.0|
Pars Intermedia, Hyperplasia, Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectopic Tissue | X | 1 |
Follicle, Cyst, Multiple | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Hyperplasia, | | |
Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis, Diffuse | 2 | 1 2.0|
Cyst | | 1 |
Bilateral, Abscess, Chronic Active, | | |
Multifocal | | 1 4.0|
Bilateral, Periovarian Tissue, Cyst | | 1 |
Follicle, Cyst | X X | 2 |
Left, Follicle, Cyst | | 2 |
Periovarian Tissue, Cyst | X | 1 |
Periovarian Tissue, Right, Cyst | X X X X | 4 |
Periovarian Tissue, Left, Cyst | X X | 3 |
Right, Follicle, Cyst | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Endometrium, Angiectasis, Focal | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic, | | |
Diffuse, Glandular | 2 2 2 3 2 2 2 3 3 3 3 3 3 3 3 3 2 3 3 3 2 2 3 2| 48 2.7|
Endometrium, Metaplasia, Squamous | 2 | 1 2.0|
Lumen, Dilatation | X X | 2 |
Lumen, Dilatation, Diffuse | 3 | 1 3.0|
Lumen, Dilatation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + +| 13 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Bronchial, Hyperplasia, Diffuse, | | |
Lymphoid | | 1 3.0|
Lumbar, Sinus, Ectasia, Focal | | 1 3.0|
Mediastinal, Pigmentation, Diffuse | 2 | 1 2.0|
Mesenteric, Angiectasis, Diffuse | 2 3 | 5 2.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoid Follicle, Depletion | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoid, Diffuse | | 2 2.0|
Lymphoid Follicle, Hyperplasia, | | |
Diffuse, Lymphoid | 3 | 2 3.0|
Lymphoid Follicle, Hyperplasia, | | |
Lymphoid | | 1 3.0|
Lymphoid Follicle, Hyperplasia, | | |
Lymphoid, Multifocal | | 1 2.0|
Red Pulp, Angiectasis, Multifocal | 2 | 1 2.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | 3 3 | 4 2.8|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
Atrophy, Diffuse | 3 | 1 3.0|
Depletion Lymphoid, Diffuse | 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M + M M M M M M M M + M M + M + M + + M + M +| 19 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 |
Face, Subcutaneous Tissue, | | |
Inflammation, Focal, | | |
Granulomatous | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Myelofibrosis, Multifocal | | 1 2.0|
Femur, Myelofibrosis, Diffuse | | 2 3.5|
Femur, Myelofibrosis, Focal | 1 2 2 | 4 1.5|
Femur, Myelofibrosis, Multifocal | 3 2 2 2 2 2 2 2 2 2| 19 2.1|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression, Focal | | 1 4.0|
Meninges, Infiltration Cellular, | | |
Multifocal, Lymphocyte | 2 | 3 2.0|
Thalamus, Mineralization | 1 | 4 1.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Focal, Granulomatous | | 1 1.0|
Inflammation, Focal, Subacute | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 3 1.7|
Mediastinum, Infiltration Cellular, | | |
Multifocal, Lymphocyte | | 1 3.0|
Vein, Intima, Mineralization, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Mucosa, Inflammation, Acute, | | |
Multifocal | | 1 2.0|
Submucosa, Glands, Ectasia, | | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 1 |
Developmental Malformation | X | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + +| 35 |
Hyperplasia, Focal | 1| 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Inflammation, Multifocal, | | |
Subacute | | 1 2.0|
Cortex, Infarct, Chronic | 2 | 1 2.0|
Cortex, Metaplasia, Focal, Osseous | | 1 2.0|
Glomerulus, Inflammation, Diffuse, | | |
Proliferative | | 1 3.0|
Renal Tubule, Casts Protein, Diffuse | | 1 2.0|
Renal Tubule, Cytoplasmic Alteration,| | |
Diffuse | 3 | 1 3.0|
Renal Tubule, Cytoplasmic Alteration,| | |
Multifocal | 2 | 1 2.0|
Renal Tubule, Degeneration, Diffuse | | 1 3.0|
Renal Tubule, Degeneration | 1 | 1 1.0|
Renal Tubule, Regeneration, Focal | 1 1 | 3 1.3|
Renal Tubule, Regeneration, | | |
Multifocal | 2 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 2| 6| 5| 6| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 6| 7| 4| 9| 9| 3| 3|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| 0| 0| 9| 8| 2| 0| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Small | |
Jejunum, Peyer's Patch, Hyperplasia, | |
Diffuse, Lymphoid | |
__________________________________________________________________________|
Liver | + + + A |
Eosinophilic Focus, Single | |
Hepatocyte, Necrosis, Acute, | |
Multifocal | |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis, Chronic, Focal | |
__________________________________________________________________________|
Pharynx | + |
Palate, Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + |
Forestomach, Epithelium, Hyperplasia,| |
Focal | 4 4 4 4 4 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + |
Bilateral, Abscess, Chronic Active, | |
Multifocal | 4 |
Bilateral, Periovarian Tissue, Cyst | X |
Follicle, Cyst | X X |
Left, Abscess, Chronic, Focal | 3 |
Left, Follicle, Cyst | |
Periovarian Tissue, Cyst | X X X |
Periovarian Tissue, Right, Cyst | X X X X |
Periovarian Tissue, Left, Cyst | X |
Right, Abscess, Chronic Active, | |
Single | 3 |
Right, Follicle, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + A + + +|
Endometrium, Hyperplasia, Cystic, | |
Diffuse, Glandular | 3 2 3 3 3 3 2 3 3 3 2 3 2 3 3 3 3 3 3|
Endometrium, Inflammation, Focal, | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 2| 6| 5| 6| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 6| 7| 4| 9| 9| 3| 3|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| 0| 0| 9| 8| 2| 0| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Suppurative | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + A + |
Lumbar, Hyperplasia, Diffuse, | |
Lymphoid | |
Mesenteric, Angiectasis, Multifocal | 2 |
Mesenteric, Hyperplasia, Diffuse, | |
Lymphoid | 2 |
Renal, Hyperplasia, Diffuse, Lymphoid| 2 |
__________________________________________________________________________|
Spleen | + + + + A |
Inflammation, Chronic | |
Lymphoid Follicle, Hyperplasia, | |
Diffuse, Lymphoid | 3 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 2 |
__________________________________________________________________________|
Thymus | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + |
__________________________________________________________________________|
Skin | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | I + |
Vertebra, Myelofibrosis, Multifocal | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Spinal Cord | |
Thoracic, Hemorrhage, Acute, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 0| 3| 1| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 3| 0| 0| 0| 0| 0| 0| 8| 0| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
5000 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Small | + + | 2 |
Jejunum, Peyer's Patch, Hyperplasia, | | |
Diffuse, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + +| 6 |
Eosinophilic Focus, Single | X | 1 |
Hepatocyte, Necrosis, Acute, | | |
Multifocal | 3| 1 3.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis, Chronic, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Palate, Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + | 14 |
Forestomach, Epithelium, Hyperplasia,| | |
Focal | 4 4 2 4 | 10 3.8|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | +| 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | +| 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 22 |
Bilateral, Abscess, Chronic Active, | | |
Multifocal | | 1 4.0|
Bilateral, Periovarian Tissue, Cyst | X | 2 |
Follicle, Cyst | | 2 |
Left, Abscess, Chronic, Focal | 3 | 2 3.0|
Left, Follicle, Cyst | X | 1 |
Periovarian Tissue, Cyst | | 3 |
Periovarian Tissue, Right, Cyst | X X | 6 |
Periovarian Tissue, Left, Cyst | X X X | 4 |
Right, Abscess, Chronic Active, | | |
Single | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 0| 3| 1| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 3| 0| 0| 0| 0| 0| 0| 8| 0| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
5000 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Right, Follicle, Cyst | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 40 |
Endometrium, Hyperplasia, Cystic, | | |
Diffuse, Glandular | 3 3 3 3 3 3 2 2 2 3 3 2 3 3 3 3 3 3 2 | 38 2.8|
Endometrium, Inflammation, Focal, | | |
Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + +| 9 |
Lumbar, Hyperplasia, Diffuse, | | |
Lymphoid | 2 | 1 2.0|
Mesenteric, Angiectasis, Multifocal | | 1 2.0|
Mesenteric, Hyperplasia, Diffuse, | | |
Lymphoid | | 1 2.0|
Renal, Hyperplasia, Diffuse, Lymphoid| | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + +| 9 |
Inflammation, Chronic | 4 | 1 4.0|
Lymphoid Follicle, Hyperplasia, | | |
Diffuse, Lymphoid | | 1 3.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | 3| 2 2.5|
__________________________________________________________________________|____________|
Thymus | +| 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 1 |
__________________________________________________________________________|____________|
Skin | +| 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 2 |
Vertebra, Myelofibrosis, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | +| 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Thoracic, Hemorrhage, Acute, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 0| 3| 1| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 3| 0| 0| 0| 0| 0| 0| 8| 0| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
5000 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2|
| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10000 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + A + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + A + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + A + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Single | X X |
Clear Cell Focus | |
Inflammation, Granulomatous, | |
Multifocal | 2 |
Hepatocyte, Necrosis, Acute, Diffuse | |
Hepatocyte, Necrosis, Acute, | |
Multifocal | 3 |
Hepatocyte, Nuclear Alteration, Focal| 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Multifocal | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + M + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Acinus, Atrophy, Diffuse | 3 |
Acinus, Atrophy, Focal | |
Acinus, Atrophy, Multifocal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + M + + + M + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 3 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
__________________________________________________________________________|
Stomach | + + + + + + A + + + + + + + + + + + + + + + + + +|
Forestomach, Epithelium, Hyperplasia,| |
Focal | 3 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + +|
Peridontal Tissue, Inflammation, | |
Acute, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spindle Cell, Hyperplasia, Diffuse | 2 2 2 2 2 2 2 2 3 2 3 2 2 2 2 2 2 2 2 2 3 3 2|
Spindle Cell, Hyperplasia, Multifocal| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + M + + + + M + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2|
| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10000 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cyst | X|
Pars Distalis, Hyperplasia, Focal | 2 |
Pars Distalis, Hyperplasia, | |
Multifocal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X|
Follicle, Cyst, Multiple | |
Follicle, Inflammation, Focal, | |
Granulomatous | 2 |
Follicle, Inflammation, Multifocal, | |
Subacute | 2 |
Follicular Cell, Hyperplasia, Cystic,| |
Focal | |
Follicular Cell, Hyperplasia, | |
Multifocal | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + A + + + A + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Bilateral, Periovarian Tissue, Cyst | X X |
Follicle, Cyst | X X|
Left, Follicle, Cyst | X |
Periovarian Tissue, Cyst | X X X |
Periovarian Tissue, Right, Cyst | |
Periovarian Tissue, Left, Cyst | X X X |
__________________________________________________________________________|
Uterus | + + + + + + A + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic, Diffuse, | |
Glandular | 3 |
Endometrium, Angiectasis | 3 |
Endometrium, Hyperplasia, Cystic, | |
Diffuse, Glandular | 2 3 2 2 3 3 3 2 1 2 3 2 2 3 3 2 2 3 2 3 3 2|
Endometrium, Metaplasia, Squamous | |
Lumen, Dilatation, Diffuse | 4 |
Lumen, Dilatation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Diffuse, | |
Neutrophil | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2|
| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10000 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mandibular, Hyperplasia, Diffuse, | |
Lymphoid | |
Mediastinal, Hyperplasia, Diffuse, | |
Lymphoid | |
Renal, Hyperplasia, Diffuse, Lymphoid| |
__________________________________________________________________________|
Spleen | + + + + + + A + + + + + + + + + + + + + + + + + +|
Capsule, Inflammation, Acute, Diffuse| 2 |
Lymphoid Follicle, Depletion | |
Lymphoid, Diffuse | |
Lymphoid Follicle, Hyperplasia, | |
Diffuse, Lymphoid | 2 2 3 |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid, Multifocal | 2 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 2 |
__________________________________________________________________________|
Thymus | + + + + M + M + + + M + + + + + + M + + + + + + +|
Depletion Lymphoid, Diffuse | |
Medulla, Hyperplasia, Diffuse, | |
Lymphoid | 2 |
Thymocyte, Necrosis, Acute, Diffuse | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + M + + + M + M M M M + M + M + M M M + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Myelofibrosis, Focal | |
Cranium, Myelofibrosis | 2 2 |
Cranium, Myelofibrosis, Multifocal | |
Cranium, Femur, Myelofibrosis, | |
Diffuse | |
Cranium, Femur, Myelofibrosis, | |
Multifocal | |
Femur, Myelofibrosis, Diffuse | 2 |
Femur, Myelofibrosis, Focal | 2 2 2 1 |
Femur, Myelofibrosis, Multifocal | 2 2 2 2 3 2 2 2 3 1 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + M + + + + + + + + + + + + + + + + + +|
Compression, Focal | |
Meninges, Infiltration Cellular, | |
Multifocal, Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2|
| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10000 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Thalamus, Mineralization | 2 2|
Third Ventricle, Infiltration | |
Cellular, Multifocal, Lymphocyte | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Interstitium, Inflammation, Focal, | |
Subacute | 2 |
__________________________________________________________________________|
Nose | + + + + + + M + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 3 3 |
Capsule, Inflammation, Diffuse, | |
Subacute | 2 |
Glomerulus, Inflammation, Diffuse, | |
Subacute, Membranoproliferative | |
Interstitial Tissue, Inflammation, | |
Multifocal | 2 |
Renal Tubule, Inflammation, | |
Multifocal, Necrotizing, Subacute| |
Renal Tubule, Necrosis, Acute, | |
Multifocal | |
Renal Tubule, Pigmentation, Diffuse | |
Renal Tubule, Regeneration, | |
Multifocal | 1 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + A + + + A + + + + + + + + + + + + + +|
Serosa, Inflammation, Acute, | |
Multifocal | 1 |
Submucosa, Infiltration Cellular, | |
Multifocal, Lymphocyte | 3 2 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 4| 6| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 4| 1| 2| |
| 8| 8| 8| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 5| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
10000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + A + + + + + + + + + + + + + A A +| 45 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus, Single | | 2 |
Clear Cell Focus | X | 1 |
Inflammation, Granulomatous, | | |
Multifocal | | 1 2.0|
Hepatocyte, Necrosis, Acute, Diffuse | 1 | 1 1.0|
Hepatocyte, Necrosis, Acute, | | |
Multifocal | 1 | 2 2.0|
Hepatocyte, Nuclear Alteration, Focal| | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Acute, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + M + + + + + + + + + + + + + + M +| 47 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 1 2.0|
Acinus, Atrophy, Diffuse | | 1 3.0|
Acinus, Atrophy, Focal | 2 | 1 2.0|
Acinus, Atrophy, Multifocal | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + M +| 47 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 3.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
Forestomach, Epithelium, Hyperplasia,| | |
Focal | 3 2 2 | 4 2.5|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + +| 44 |
Peridontal Tissue, Inflammation, | | |
Acute, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Spindle Cell, Hyperplasia, Diffuse | 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 47 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 4| 6| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 4| 1| 2| |
| 8| 8| 8| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 5| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
10000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Spindle Cell, Hyperplasia, Multifocal| 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + M + + + + + + + + + + + + + + M +| 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + M + + M + + + + M + + + + M M M M| 38 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
Pars Distalis, Angiectasis, Focal | 2 | 1 2.0|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia, Focal | 2 3 | 3 2.3|
Pars Distalis, Hyperplasia, | | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M M +| 47 |
Follicle, Cyst | X | 2 |
Follicle, Cyst, Multiple | X | 1 |
Follicle, Inflammation, Focal, | | |
Granulomatous | | 1 2.0|
Follicle, Inflammation, Multifocal, | | |
Subacute | | 1 2.0|
Follicular Cell, Hyperplasia, Cystic,| | |
Focal | 2 | 1 2.0|
Follicular Cell, Hyperplasia, | | |
Multifocal | 2 2 | 4 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Focal | 3 | 1 3.0|
Bilateral, Periovarian Tissue, Cyst | | 2 |
Follicle, Cyst | X X X | 5 |
Left, Follicle, Cyst | | 1 |
Periovarian Tissue, Cyst | X X | 5 |
Periovarian Tissue, Right, Cyst | X X | 2 |
Periovarian Tissue, Left, Cyst | | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Cystic, Diffuse, | | |
Glandular | | 1 3.0|
Endometrium, Angiectasis | | 1 3.0|
Endometrium, Hyperplasia, Cystic, | | |
Diffuse, Glandular | 2 3 3 3 2 3 2 3 2 2 3 2 2 3 3 3 2 3 2 2 1 2| 44 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 4| 6| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 4| 1| 2| |
| 8| 8| 8| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 5| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
10000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Endometrium, Metaplasia, Squamous | 2 | 1 2.0|
Lumen, Dilatation, Diffuse | | 1 4.0|
Lumen, Dilatation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + | 7 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Hyperplasia, Diffuse, | | |
Neutrophil | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + M + + + + + + + + + + + + + M M +| 46 |
Mandibular, Hyperplasia, Diffuse, | | |
Lymphoid | 3 | 1 3.0|
Mediastinal, Hyperplasia, Diffuse, | | |
Lymphoid | 3 | 1 3.0|
Renal, Hyperplasia, Diffuse, Lymphoid| 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Inflammation, Acute, Diffuse| | 1 2.0|
Lymphoid Follicle, Depletion | | |
Lymphoid, Diffuse | 3 | 1 3.0|
Lymphoid Follicle, Hyperplasia, | | |
Diffuse, Lymphoid | 3 | 4 2.5|
Lymphoid Follicle, Hyperplasia, | | |
Lymphoid, Multifocal | | 1 2.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | 3 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + + + + M + + + + M M +| 42 |
Depletion Lymphoid, Diffuse | 2| 1 2.0|
Medulla, Hyperplasia, Diffuse, | | |
Lymphoid | 3 | 2 2.5|
Thymocyte, Necrosis, Acute, Diffuse | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + M M + M + + + + M + + + + + M + M M M M| 29 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Myelofibrosis, Focal | 4 | 1 4.0|
Cranium, Myelofibrosis | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 4| 6| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 4| 1| 2| |
| 8| 8| 8| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 5| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
10000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Cranium, Myelofibrosis, Multifocal | 2 | 1 2.0|
Cranium, Femur, Myelofibrosis, | | |
Diffuse | 2 2 | 2 2.0|
Cranium, Femur, Myelofibrosis, | | |
Multifocal | 4 3 2 2 2 2 2| 7 2.4|
Femur, Myelofibrosis, Diffuse | | 1 2.0|
Femur, Myelofibrosis, Focal | 2 | 5 1.8|
Femur, Myelofibrosis, Multifocal | 2 2 | 12 2.1|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Compression, Focal | 3 | 1 3.0|
Meninges, Infiltration Cellular, | | |
Multifocal, Lymphocyte | 2 | 1 2.0|
Thalamus, Mineralization | 2 | 3 2.0|
Third Ventricle, Infiltration | | |
Cellular, Multifocal, Lymphocyte | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 2 | 3 2.0|
Interstitium, Inflammation, Focal, | | |
Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + M + + + + + + + + + M + + + M M +| 44 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + A + + + + + + + + + + + + + M M +| 46 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + +| 41 |
Hyperplasia, Focal | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Multifocal, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 4| 6| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 4| 1| 2| |
| 8| 8| 8| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 5| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
10000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Lymphocyte | 2 2 | 4 2.5|
Capsule, Inflammation, Diffuse, | | |
Subacute | | 1 2.0|
Glomerulus, Inflammation, Diffuse, | | |
Subacute, Membranoproliferative | 3| 1 3.0|
Interstitial Tissue, Inflammation, | | |
Multifocal | | 1 2.0|
Renal Tubule, Inflammation, | | |
Multifocal, Necrotizing, Subacute| 2 | 1 2.0|
Renal Tubule, Necrosis, Acute, | | |
Multifocal | 2 | 1 2.0|
Renal Tubule, Pigmentation, Diffuse | 2 | 1 2.0|
Renal Tubule, Regeneration, | | |
Multifocal | 1 2 2| 7 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
Serosa, Inflammation, Acute, | | |
Multifocal | | 1 1.0|
Submucosa, Infiltration Cellular, | | |
Multifocal, Lymphocyte | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 6| 2| 6| 2| 2| 2| 8| 5| 2| 2| 2| 8| 8| 2| 9| 2| 2| 7| 2| 7| 2| 2| 1| 2|
| 7| 0| 7| 1| 7| 7| 7| 7| 1| 7| 7| 7| 2| 2| 7| 0| 7| 7| 5| 7| 8| 7| 7| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + + + + + + + + + + + + + + + + A + + A +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + A + + + + + +|
Colon, Parasite Metazoan, Single | |
__________________________________________________________________________|
Intestine Large, Cecum | + M + + + + + + + + + M M + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A M +|
__________________________________________________________________________|
Intestine Large, Rectum | + M + M + + + + + + M M + + A + +|
__________________________________________________________________________|
Intestine Small | + A + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis, Acute, Multifocal | 3 |
Jejunum, Peyer's Patch, Hyperplasia, | |
Lymphoid, Multifocal | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + M M + + + + + + + + M + M M + +|
__________________________________________________________________________|
Intestine Small, Ileum | + M + + + + + + + + + M + + M + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X |
Basophilic Focus, Single | |
Inflammation, Granulomatous, | |
Multifocal | |
Bile Duct, Hyperplasia, Multifocal | |
Hepatocyte, Necrosis, Acute, | |
Multifocal | 2 2 |
Hepatocyte, Necrosis, Coagulative, | |
Multifocal, Subacute | |
Hepatocyte, Nuclear Alteration, | |
Diffuse | |
Hepatocyte, Nuclear Alteration, Focal| 1 1 1 1 1 1 2 2 2 |
Hepatocyte, Nuclear Alteration, | |
Multifocal | 1 |
Hepatocyte, Syncytial Alteration, | |
Diffuse | 1 1 1 1 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Epithelium, Hyperplasia,| |
Focal | 4 4 2 4 |
Glandular, Dysplasia, Focal | 2 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + +|
Peridontal Tissue, Inflammation, | |
Acute, Focal | |
Peridontal Tissue, Inflammation, | |
Acute, Multifocal | 2 |
Peridontal Tissue, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 6| 2| 6| 2| 2| 2| 8| 5| 2| 2| 2| 8| 8| 2| 9| 2| 2| 7| 2| 7| 2| 2| 1| 2|
| 7| 0| 7| 1| 7| 7| 7| 7| 1| 7| 7| 7| 2| 2| 7| 0| 7| 7| 5| 7| 8| 7| 7| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Chronic Active, Focal | 3 2 3 |
Peridontal Tissue, Inflammation, | |
Chronic Active, Multifocal | 2 |
Pulp, Inflammation, Acute, Focal | 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Chronic, | |
Focal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Degeneration, Fatty, Focal | 2 |
Cortex, Focal Cellular Change | X X |
Cortex, Focal Cellular Change, | |
Multifocal | |
Cortex, Hyperplasia, Focal | 2 |
Medulla, Hyperplasia, Focal | |
Spindle Cell, Hyperplasia, Multifocal| 2 2 3 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M M + + + + + + M + + + + M + M + + + + + M M|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + M + M|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst, Single | X X X X |
Follicular Cell, Hyperplasia, Focal | |
Follicular Cell, Hyperplasia, | |
Multifocal | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Wall, Inflammation, Acute, Multifocal| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm, Focal | |
Inflammation, Chronic, Focal | 1 |
__________________________________________________________________________|
Penis | + |
Inflammation, Acute, Focal | |
__________________________________________________________________________|
Preputial Gland | + + + + |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 6| 2| 6| 2| 2| 2| 8| 5| 2| 2| 2| 8| 8| 2| 9| 2| 2| 7| 2| 7| 2| 2| 1| 2|
| 7| 0| 7| 1| 7| 7| 7| 7| 1| 7| 7| 7| 2| 2| 7| 0| 7| 7| 5| 7| 8| 7| 7| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Abscess, Chronic, Focal | 4 3 |
Bilateral, Abscess, Chronic | |
Bilateral, Inflammation, | |
Granulomatous, Multifocal, | |
Suppurative | 3 |
Duct, Ectasia, Focal | 3 |
Duct, Ectasia, Multifocal | |
Right, Abscess, Chronic, Focal | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Diffuse | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + |
Inflammation, Acute, Focal | |
Lumen, Dilatation, Diffuse | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy, Focal | 2 |
Germinal Epithelium, Atrophy, | |
Multifocal | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + |
Leukocytosis | 3 |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Diffuse, | |
Neutrophil | |
Femoral, Hypoplasia, Focal | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Diffuse, | |
Lymphoid | |
Inguinal, Infiltration Cellular, | |
Diffuse, Plasma Cell | |
Lumbar, Hemorrhage, Acute, Diffuse | 3 |
Lumbar, Hyperplasia, Diffuse, Plasma | |
Cell | |
Lumbar, Infiltration Cellular, | |
Diffuse, Plasma Cell | 2 |
Lumbar, Infiltration Cellular, | |
Diffuse, Polymorphonuclear | 2 |
Mandibular, Hematopoietic Cell | |
Proliferation, Diffuse | 2 |
Mandibular, Hyperplasia, Diffuse, | |
Lymphoid | 2 |
Mandibular, Infiltration Cellular, | |
Diffuse, Plasma Cell | 2 3 2 |
Mesenteric, Angiectasis, Diffuse | 3 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 6| 2| 6| 2| 2| 2| 8| 5| 2| 2| 2| 8| 8| 2| 9| 2| 2| 7| 2| 7| 2| 2| 1| 2|
| 7| 0| 7| 1| 7| 7| 7| 7| 1| 7| 7| 7| 2| 2| 7| 0| 7| 7| 5| 7| 8| 7| 7| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesenteric, Angiectasis, Multifocal | |
Mesenteric, Erythrophagocytosis, | |
Diffuse | 2|
Mesenteric, Hematopoietic Cell | |
Proliferation, Diffuse | 2 2 2|
Pancreatic, Inflammation, Acute, | |
Diffuse | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | M M M M M M M|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M + + M M M|
__________________________________________________________________________|
Lymph Node, Mesenteric | M + M + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Fibrosis, Focal | |
Lymphoid Follicle, Depletion | |
Lymphoid, Multifocal | |
Lymphoid Follicle, Hyperplasia, | |
Diffuse, Lymphoid | |
Lymphoid Follicle, Hyperplasia, | |
Focal, Lymphoid | 3 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 3 2 3 4 3 3 |
Red Pulp, Infiltration Cellular, | |
Focal, Plasma Cell | |
__________________________________________________________________________|
Thymus | + + + M + + + + M + + + M + + M + + + + + + + M +|
Depletion Lymphoid, Diffuse | 3 2 3 |
Thymocyte, Necrosis, Acute, Diffuse | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Diffuse | |
Acanthosis, Focal | |
Hyperkeratosis, Diffuse | |
Inflammation, Acute, Focal | |
Inflammation, Focal, Subacute | 1 |
Back, Fibrosis, Diffuse | 3 |
Back, Fibrosis, Focal | |
Back, Hyperplasia, Diffuse, | |
Pseudoepitheliomatous | |
Back, Inflammation, Chronic, Diffuse | |
Back, Inflammation, Chronic Active, | |
Diffuse | 2 |
Back, Ulcer, Acute, Diffuse | 3 |
Back, Ulcer, Acute, Focal | 3 2 |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 6| 2| 6| 2| 2| 2| 8| 5| 2| 2| 2| 8| 8| 2| 9| 2| 2| 7| 2| 7| 2| 2| 1| 2|
| 7| 0| 7| 1| 7| 7| 7| 7| 1| 7| 7| 7| 2| 2| 7| 0| 7| 7| 5| 7| 8| 7| 7| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Back, Ulcer, Chronic Active, Focal | 3 |
Back, Ulcer, Chronic Active, | |
Multifocal | 3 |
Dermis, Fibrosis, Focal | |
Dermis, Inflammation, Focal, Subacute| |
Face, Ulcer, Chronic Active, | |
Multifocal | |
Face, Subcutaneous Tissue, | |
Inflammation, Chronic Active, | |
Focal | 2 |
Neck, Subcutaneous Tissue, | |
Inflammation, Acute, Focal | 2 |
Prepuce, Ulcer, Acute, Focal | |
Right, Inflammation, Chronic Active, | |
Focal | 3 |
Subcutaneous Tissue, Inflammation, | |
Acute, Focal | |
Subcutaneous Tissue, Inflammation, | |
Chronic, Diffuse | |
Subcutaneous Tissue, Inflammation, | |
Focal, Granulomatous | 2 |
Thoracic, Fibrosis, Focal | |
Thoracic, Ulcer, Chronic Active, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Joint, Tarsal, Arthrosis, | |
Chronic | 2 3 3 3 3 3 2 3 2 3 3 3 3 3 3|
Joint, Right, Tarsal, Inflammation, | |
Chronic Active, Diffuse | 3 |
Unilateral, Joint, Tarsal, Arthrosis,| |
Chronic | 2 3 3 3 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Perivascular Cuffing, | |
Focal | |
Meninges, Perivascular Cuffing, Focal| |
Meninges, Perivascular Cuffing, | |
Multifocal | |
Thalamus, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 6| 2| 6| 2| 2| 2| 8| 5| 2| 2| 2| 8| 8| 2| 9| 2| 2| 7| 2| 7| 2| 2| 1| 2|
| 7| 0| 7| 1| 7| 7| 7| 7| 1| 7| 7| 7| 2| 2| 7| 0| 7| 7| 5| 7| 8| 7| 7| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Diffuse, Subacute | |
Infiltration Cellular, Diffuse, | |
Histiocyte | |
Infiltration Cellular, Focal, | |
Histiocyte | 1|
Inflammation, Acute, Multifocal | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 1 3 2 2|
Capillary, Infiltration Cellular, | |
Acute, Diffuse, | |
Polymorphonuclear | 3 |
Capillary, Infiltration Cellular, | |
Diffuse, Polymorphonuclear | 2 |
Interstitium, Inflammation, | |
Multifocal, Subacute | |
Right, Edema, Chronic, Diffuse | 4 |
__________________________________________________________________________|
Nose | + + + M + + + + + + + + + + + M + + M + + + + + +|
Mucosa, Inflammation, Acute | |
Mucosa, Inflammation, Acute, | |
Multifocal | 2 |
Nasolacrimal Duct, Inflammation, | |
Acute, Multifocal | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Cyst, Focal | |
Cortex, Infarct, Chronic, Focal | 2|
Cortex, Inflammation, Acute, Focal | 1 |
Corticomedullary Junction, | |
Angiectasis, Multifocal | 2 |
Corticomedullary Junction, | |
Thrombosis, Chronic, Focal | |
Left, Inflammation, Chronic Active, | |
Diffuse | |
Renal Tubule, Dilatation, Focal | |
Renal Tubule, Necrosis, Diffuse, | |
Subacute | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 6| 2| 6| 2| 2| 2| 8| 5| 2| 2| 2| 8| 8| 2| 9| 2| 2| 7| 2| 7| 2| 2| 1| 2|
| 7| 0| 7| 1| 7| 7| 7| 7| 1| 7| 7| 7| 2| 2| 7| 0| 7| 7| 5| 7| 8| 7| 7| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Regeneration, Focal | |
Renal Tubule, Regeneration, | |
Multifocal | 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + + + +|
Submucosa, Inflammation, Acute, | |
Diffuse | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 7| 6| 7| |
DAY ON TEST | 0| 2| 1| 2| 2| 2| 8| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 0| 2| |
| 7| 7| 7| 7| 7| 7| 9| 7| 8| 0| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 8| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + M + + + A M + + + + + + + + + A + + + + + M +| 42 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
Colon, Parasite Metazoan, Single | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + + + M M M | 17 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + M + + | 22 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + + + M M M | 16 |
__________________________________________________________________________|____________|
Intestine Small | A + A + + + A + + + + + + + + + + M + + + + + M +| 44 |
Thrombosis, Acute, Multifocal | | 1 3.0|
Jejunum, Peyer's Patch, Hyperplasia, | | |
Lymphoid, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + M M M | 16 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + M M M | 18 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + M + M | 21 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus, Multiple | | 1 |
Basophilic Focus, Single | X X | 2 |
Inflammation, Granulomatous, | | |
Multifocal | 3 | 1 3.0|
Bile Duct, Hyperplasia, Multifocal | 2 | 1 2.0|
Hepatocyte, Necrosis, Acute, | | |
Multifocal | | 2 2.0|
Hepatocyte, Necrosis, Coagulative, | | |
Multifocal, Subacute | 3 | 1 3.0|
Hepatocyte, Nuclear Alteration, | | |
Diffuse | 1 1 | 2 1.0|
Hepatocyte, Nuclear Alteration, Focal| 1 1 1 1 1 1 | 15 1.2|
Hepatocyte, Nuclear Alteration, | | |
Multifocal | 1 | 2 1.0|
Hepatocyte, Syncytial Alteration, | | |
Diffuse | 1 1 1 1 1 1 | 11 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + A + + + + + + + + + + M + + + + + + +| 48 |
Forestomach, Epithelium, Hyperplasia,| | |
Focal | 4 | 5 3.6|
Glandular, Dysplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + +| 40 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 7| 6| 7| |
DAY ON TEST | 0| 2| 1| 2| 2| 2| 8| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 0| 2| |
| 7| 7| 7| 7| 7| 7| 9| 7| 8| 0| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 8| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Peridontal Tissue, Inflammation, | | |
Acute, Focal | 1 1 | 2 1.0|
Peridontal Tissue, Inflammation, | | |
Acute, Multifocal | 3 | 2 2.5|
Peridontal Tissue, Inflammation, | | |
Chronic Active, Focal | 2 3 3 | 6 2.7|
Peridontal Tissue, Inflammation, | | |
Chronic Active, Multifocal | | 1 2.0|
Pulp, Inflammation, Acute, Focal | 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myocardium, Inflammation, Chronic, | | |
Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Cortex, Degeneration, Fatty, Focal | | 1 2.0|
Cortex, Focal Cellular Change | X X | 4 |
Cortex, Focal Cellular Change, | | |
Multifocal | X | 1 |
Cortex, Hyperplasia, Focal | 2 3 | 3 2.3|
Medulla, Hyperplasia, Focal | 2 | 1 2.0|
Spindle Cell, Hyperplasia, Multifocal| 2 2 3 1 | 7 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + M + + | 17 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + M + + | 17 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + M + + + + + M M + + M + + + +| 38 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + I + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Cyst, Single | X | 5 |
Follicular Cell, Hyperplasia, Focal | 1 | 1 1.0|
Follicular Cell, Hyperplasia, | | |
Multifocal | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 7| 6| 7| |
DAY ON TEST | 0| 2| 1| 2| 2| 2| 8| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 0| 2| |
| 7| 7| 7| 7| 7| 7| 9| 7| 8| 0| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 8| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + + | 4 |
Wall, Inflammation, Acute, Multifocal| 2 | 1 2.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + M + + + M + + +| 48 |
Granuloma Sperm, Focal | 2 | 1 2.0|
Inflammation, Chronic, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Penis | + + M + +| 5 |
Inflammation, Acute, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + M + | 10 |
Abscess, Chronic, Focal | 4 | 3 3.7|
Bilateral, Abscess, Chronic | 3 3 | 2 3.0|
Bilateral, Inflammation, | | |
Granulomatous, Multifocal, | | |
Suppurative | | 1 3.0|
Duct, Ectasia, Focal | | 1 3.0|
Duct, Ectasia, Multifocal | 2 | 1 2.0|
Right, Abscess, Chronic, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + M M + + + + + + +| 48 |
Inflammation, Acute, Diffuse | 4 | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | A + + + + + + + + + + + +| 17 |
Inflammation, Acute, Focal | 2 | 1 2.0|
Lumen, Dilatation, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + M + + + M + + +| 48 |
Germinal Epithelium, Atrophy, Focal | | 1 2.0|
Germinal Epithelium, Atrophy, | | |
Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + M | 12 |
Leukocytosis | | 1 3.0|
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Hyperplasia, Diffuse, | | |
Neutrophil | 3 | 1 3.0|
Femoral, Hypoplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | M + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
Inguinal, Hyperplasia, Diffuse, | | |
Lymphoid | 3 | 1 3.0|
Inguinal, Infiltration Cellular, | | |
Diffuse, Plasma Cell | 3 | 1 3.0|
Lumbar, Hemorrhage, Acute, Diffuse | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 7| 6| 7| |
DAY ON TEST | 0| 2| 1| 2| 2| 2| 8| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 0| 2| |
| 7| 7| 7| 7| 7| 7| 9| 7| 8| 0| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 8| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Hyperplasia, Diffuse, Plasma | | |
Cell | 1 | 1 1.0|
Lumbar, Infiltration Cellular, | | |
Diffuse, Plasma Cell | | 1 2.0|
Lumbar, Infiltration Cellular, | | |
Diffuse, Polymorphonuclear | | 1 2.0|
Mandibular, Hematopoietic Cell | | |
Proliferation, Diffuse | | 1 2.0|
Mandibular, Hyperplasia, Diffuse, | | |
Lymphoid | | 1 2.0|
Mandibular, Infiltration Cellular, | | |
Diffuse, Plasma Cell | | 3 2.3|
Mesenteric, Angiectasis, Diffuse | 3 2 3 2 2 | 10 2.3|
Mesenteric, Angiectasis, Multifocal | 2 | 1 2.0|
Mesenteric, Erythrophagocytosis, | | |
Diffuse | | 1 2.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation, Diffuse | 2 2 | 5 2.0|
Pancreatic, Inflammation, Acute, | | |
Diffuse | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M M M M | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + M + + | 20 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M M M M | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + M M M | 7 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Capsule, Fibrosis, Focal | 2 | 1 2.0|
Lymphoid Follicle, Depletion | | |
Lymphoid, Multifocal | 2 | 1 2.0|
Lymphoid Follicle, Hyperplasia, | | |
Diffuse, Lymphoid | 2 | 1 2.0|
Lymphoid Follicle, Hyperplasia, | | |
Focal, Lymphoid | | 1 3.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | 2 2 3 2 | 10 2.7|
Red Pulp, Infiltration Cellular, | | |
Focal, Plasma Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + M M + + + + + M M + + M M + + + + + + M + + +| 38 |
Depletion Lymphoid, Diffuse | | 3 2.7|
Thymocyte, Necrosis, Acute, Diffuse | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 7| 6| 7| |
DAY ON TEST | 0| 2| 1| 2| 2| 2| 8| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 0| 2| |
| 7| 7| 7| 7| 7| 7| 9| 7| 8| 0| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 8| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M + M M M M| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis, Diffuse | 2 | 1 2.0|
Acanthosis, Focal | 1 | 1 1.0|
Hyperkeratosis, Diffuse | 2 | 1 2.0|
Inflammation, Acute, Focal | 1 | 1 1.0|
Inflammation, Focal, Subacute | | 1 1.0|
Back, Fibrosis, Diffuse | 3 | 2 3.0|
Back, Fibrosis, Focal | 3 | 1 3.0|
Back, Hyperplasia, Diffuse, | | |
Pseudoepitheliomatous | 3 | 1 3.0|
Back, Inflammation, Chronic, Diffuse | 3 | 1 3.0|
Back, Inflammation, Chronic Active, | | |
Diffuse | | 1 2.0|
Back, Ulcer, Acute, Diffuse | | 1 3.0|
Back, Ulcer, Acute, Focal | 2 | 3 2.3|
Back, Ulcer, Chronic Active, Focal | | 1 3.0|
Back, Ulcer, Chronic Active, | | |
Multifocal | 3 | 2 3.0|
Dermis, Fibrosis, Focal | 2 | 1 2.0|
Dermis, Inflammation, Focal, Subacute| 1 | 1 1.0|
Face, Ulcer, Chronic Active, | | |
Multifocal | 3 | 1 3.0|
Face, Subcutaneous Tissue, | | |
Inflammation, Chronic Active, | | |
Focal | | 1 2.0|
Neck, Subcutaneous Tissue, | | |
Inflammation, Acute, Focal | | 1 2.0|
Prepuce, Ulcer, Acute, Focal | 3 | 1 3.0|
Right, Inflammation, Chronic Active, | | |
Focal | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Acute, Focal | 2 | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic, Diffuse | 2 | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Focal, Granulomatous | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 7| 6| 7| |
DAY ON TEST | 0| 2| 1| 2| 2| 2| 8| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 0| 2| |
| 7| 7| 7| 7| 7| 7| 9| 7| 8| 0| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 8| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Thoracic, Fibrosis, Focal | 3 | 1 3.0|
Thoracic, Ulcer, Chronic Active, | | |
Multifocal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Joint, Tarsal, Arthrosis, | | |
Chronic | 2 3 2 3 3 3 2 3 3 3 2 3 2 3 3 3| 31 2.7|
Joint, Right, Tarsal, Inflammation, | | |
Chronic Active, Diffuse | | 1 3.0|
Unilateral, Joint, Tarsal, Arthrosis,| | |
Chronic | 3 3 3 | 9 2.7|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cerebellum, Perivascular Cuffing, | | |
Focal | 2 | 1 2.0|
Meninges, Perivascular Cuffing, Focal| 1 | 1 1.0|
Meninges, Perivascular Cuffing, | | |
Multifocal | 2 | 1 2.0|
Thalamus, Mineralization | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Diffuse, Subacute | 2 | 1 2.0|
Infiltration Cellular, Diffuse, | | |
Histiocyte | 2 | 1 2.0|
Infiltration Cellular, Focal, | | |
Histiocyte | | 1 1.0|
Inflammation, Acute, Multifocal | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 6 1.8|
Capillary, Infiltration Cellular, | | |
Acute, Diffuse, | | |
Polymorphonuclear | | 1 3.0|
Capillary, Infiltration Cellular, | | |
Diffuse, Polymorphonuclear | | 1 2.0|
Interstitium, Inflammation, | | |
Multifocal, Subacute | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 0| 7| 6| 7| |
DAY ON TEST | 0| 2| 1| 2| 2| 2| 8| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 0| 2| |
| 7| 7| 7| 7| 7| 7| 9| 7| 8| 0| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 8| 5| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Right, Edema, Chronic, Diffuse | | 1 4.0|
__________________________________________________________________________|____________|
Nose | M + + + + + + + + + + + + + + + + M + + + M + M +| 43 |
Mucosa, Inflammation, Acute | 2 | 1 2.0|
Mucosa, Inflammation, Acute, | | |
Multifocal | 2 | 2 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + M | 1 |
Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + +| 44 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Cortex, Cyst, Focal | X | 1 |
Cortex, Infarct, Chronic, Focal | | 1 2.0|
Cortex, Inflammation, Acute, Focal | | 1 1.0|
Corticomedullary Junction, | | |
Angiectasis, Multifocal | | 1 2.0|
Corticomedullary Junction, | | |
Thrombosis, Chronic, Focal | 3 | 1 3.0|
Left, Inflammation, Chronic Active, | | |
Diffuse | 3 | 1 3.0|
Renal Tubule, Dilatation, Focal | 1 | 1 1.0|
Renal Tubule, Necrosis, Diffuse, | | |
Subacute | 3 | 1 3.0|
Renal Tubule, Regeneration, Focal | 2 2 1 | 3 1.7|
Renal Tubule, Regeneration, | | |
Multifocal | 2 2 2 2 2 | 8 1.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
Submucosa, Inflammation, Acute, | | |
Diffuse | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 4| 6| 1| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 2| 2| 2| 8| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 6| 5| 0| 2| 7| 2| 2| 1| 2|
| 9| 3| 9| 9| 9| 2| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| 7| 5| 9| 6| 4| 9| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Large | + |
__________________________________________________________________________|
Intestine Small | A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + A + + + + + +|
Basophilic Focus, Single | |
Inflammation, Multifocal, Subacute | 1 |
Caudate Lobe, Necrosis, Chronic | |
Active, Focal | |
Hepatocyte, Cytomegaly, Diffuse | |
Hepatocyte, Cytomegaly | |
Hepatocyte, Cytomegaly, Multifocal | |
Hepatocyte, Necrosis, Acute, | |
Multifocal | 2 1 4 |
Hepatocyte, Nuclear Alteration, Focal| 1 1 1 1 2 1 1 2 1 1 2 1 2|
Hepatocyte, Nuclear Alteration, | |
Multifocal | 1 1 |
Hepatocyte, Syncytial Alteration, | |
Diffuse | 1 2 2 2 2 1 2 2 1 1 2 2 1 1 1 1 1 2 1 2|
Sinusoid, Infiltration Cellular, | |
Diffuse, Polymorphonuclear | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis, Multifocal | |
__________________________________________________________________________|
Stomach | + + + |
Forestomach, Epithelium, Hyperplasia,| |
Focal | 4 4 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Penis | + + M |
__________________________________________________________________________|
Preputial Gland | + + + |
Abscess, Chronic, Focal | 4 |
Duct, Ectasia, Focal | 4 |
Duct, Ectasia, Multifocal | |
Left, Abscess, Chronic, Focal | |
Right, Abscess, Chronic Active, Focal| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation, Diffuse | 3 3 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 4| 6| 1| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 2| 2| 2| 8| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 6| 5| 0| 2| 7| 2| 2| 1| 2|
| 9| 3| 9| 9| 9| 2| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| 7| 5| 9| 6| 4| 9| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Dilatation | 3 |
Inflammation, Multifocal, | |
Necrotizing, Subacute | |
Artery, Inflammation, Chronic, | |
Multifocal | |
__________________________________________________________________________|
Seminal Vesicle | + + |
Dilatation, Diffuse | 3 3 |
__________________________________________________________________________|
Testes | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Lumbar, Infiltration Cellular, Focal,| |
Plasma Cell | 2 |
Mesenteric, Angiectasis, Diffuse | 2 2 |
Mesenteric, Angiectasis, Multifocal | |
Mesenteric, Hematopoietic Cell | |
Proliferation, Diffuse | 2 |
Pancreatic, Angiectasis, Multifocal | 2 2 |
Pancreatic, Hematopoietic Cell | |
Proliferation, Diffuse | 3 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + A + + + + A +|
Lymphoid Follicle, Depletion | |
Lymphoid, Multifocal | 1 3 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 2 3 2 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + |
Back, Alopecia, Focal | |
Prepuce, Inflammation, Acute, Focal | |
Prepuce, Inflammation, Acute, Focal, | |
Necrotizing | 3 3 |
Prepuce, Inflammation, Acute, | |
Multifocal, Necrotizing | 3 |
Prepuce, Inflammation, Chronic, | |
Focal, Necrotizing | 4 |
Prepuce, Inflammation, Focal, | |
Granulomatous, Necrotizing | 3 3 |
Thoracic, Inflammation, Chronic | |
Active, Diffuse | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + M + + + M + + + + + + M M M + M M + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 4| 6| 1| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 2| 2| 2| 8| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 6| 5| 0| 2| 7| 2| 2| 1| 2|
| 9| 3| 9| 9| 9| 2| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| 7| 5| 9| 6| 4| 9| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Hyperostosis | 3 |
Bilateral, Joint, Tarsal, Arthrosis, | |
Chronic | 3 3 3 2 3 2 2 3 2 2 2 2 2 2 |
Bilateral, Joint, Tarsal, Metaplasia,| |
Diffuse, Osseous | |
Joint, Tarsal, Arthrosis, Chronic | 2 |
Joint, Phalanges, Inflammation, | |
Chronic Active, Focal | 3 |
Unilateral, Joint, Tarsal, Arthrosis,| |
Chronic | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + |
Hemorrhage, Acute, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + |
Infarct, Acute, Multifocal | 4 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + |
Inflammation, Multifocal, Subacute | 3 |
Bilateral, Infarct, Acute, Multifocal| 4 |
Bilateral, Inflammation, Acute, | |
Multifocal, Suppurative | |
Corticomedullary Junction, Renal | |
Tubule, Mineralization, | |
Multifocal | 2 |
Pelvis, Inflammation, Acute, Diffuse | 2 |
Renal Tubule, Dilatation, Diffuse | 2 |
Renal Tubule, Necrosis, Acute, | |
Diffuse | |
Right, Atrophy | |
Right, Inflammation, Chronic Active, | |
Diffuse | |
__________________________________________________________________________|
Urethra | + |
Concretion, Focal | 3 |
Transitional Epithelium, Necrosis, | |
Acute, Focal | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 4| 6| 1| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 2| 2| 2| 8| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 6| 5| 0| 2| 7| 2| 2| 1| 2|
| 9| 3| 9| 9| 9| 2| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| 7| 5| 9| 6| 4| 9| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + A A |
Calculus Gross Observation | X |
Lumen, Ectasia | 3 |
Submucosa, Inflammation, Acute, | |
Diffuse | 2 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 6| 7| 6| 7| 7| 7| 7| 5| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 5| 4| 8| 3| 1| 3| 6| 3| 3| 3| 3| 1| 8| |
| 8| 0| 0| 0| 0| 0| 5| 0| 0| 0| 0| 0| 1| 7| 1| 0| 0| 0| 8| 0| 0| 0| 0| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
5000 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large | | 1 |
__________________________________________________________________________|____________|
Intestine Small | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus, Single | X | 1 |
Inflammation, Multifocal, Subacute | | 1 1.0|
Caudate Lobe, Necrosis, Chronic | | |
Active, Focal | 4 | 1 4.0|
Hepatocyte, Cytomegaly, Diffuse | 3 | 1 3.0|
Hepatocyte, Cytomegaly | 3 | 1 3.0|
Hepatocyte, Cytomegaly, Multifocal | 3 | 1 3.0|
Hepatocyte, Necrosis, Acute, | | |
Multifocal | 2 2 1 | 6 2.0|
Hepatocyte, Nuclear Alteration, Focal| 1 1 1 1 2 1 1 1 1 1 1 1 2 1| 27 1.2|
Hepatocyte, Nuclear Alteration, | | |
Multifocal | 1 | 3 1.0|
Hepatocyte, Syncytial Alteration, | | |
Diffuse | 2 2 1 1 1 1 2 1 1 1 1 1 1 | 33 1.4|
Sinusoid, Infiltration Cellular, | | |
Diffuse, Polymorphonuclear | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + | 6 |
Forestomach, Epithelium, Hyperplasia,| | |
Focal | 4 4 4 | 6 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Penis | + + | 4 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 5 |
Abscess, Chronic, Focal | | 1 4.0|
Duct, Ectasia, Focal | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 6| 7| 6| 7| 7| 7| 7| 5| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 5| 4| 8| 3| 1| 3| 6| 3| 3| 3| 3| 1| 8| |
| 8| 0| 0| 0| 0| 0| 5| 0| 0| 0| 0| 0| 1| 7| 1| 0| 0| 0| 8| 0| 0| 0| 0| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
5000 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Duct, Ectasia, Multifocal | 3 | 1 3.0|
Left, Abscess, Chronic, Focal | 3 | 1 3.0|
Right, Abscess, Chronic Active, Focal| 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Dilatation, Diffuse | | 2 3.0|
Dilatation | | 1 3.0|
Inflammation, Multifocal, | | |
Necrotizing, Subacute | 3 | 1 3.0|
Artery, Inflammation, Chronic, | | |
Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 2 |
Dilatation, Diffuse | | 2 3.0|
__________________________________________________________________________|____________|
Testes | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | M | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 11 |
Lumbar, Infiltration Cellular, Focal,| | |
Plasma Cell | | 1 2.0|
Mesenteric, Angiectasis, Diffuse | 2 2 | 4 2.0|
Mesenteric, Angiectasis, Multifocal | 2 | 1 2.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation, Diffuse | | 1 2.0|
Pancreatic, Angiectasis, Multifocal | | 2 2.0|
Pancreatic, Hematopoietic Cell | | |
Proliferation, Diffuse | | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + A + + + + + +| 46 |
Lymphoid Follicle, Depletion | | |
Lymphoid, Multifocal | 2 2 | 4 2.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | 2 3 2 3 2 2| 11 2.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + +| 21 |
Back, Alopecia, Focal | 2 | 1 2.0|
Prepuce, Inflammation, Acute, Focal | 3 | 1 3.0|
Prepuce, Inflammation, Acute, Focal, | | |
Necrotizing | | 2 3.0|
Prepuce, Inflammation, Acute, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 6| 7| 6| 7| 7| 7| 7| 5| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 5| 4| 8| 3| 1| 3| 6| 3| 3| 3| 3| 1| 8| |
| 8| 0| 0| 0| 0| 0| 5| 0| 0| 0| 0| 0| 1| 7| 1| 0| 0| 0| 8| 0| 0| 0| 0| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
5000 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Multifocal, Necrotizing | | 1 3.0|
Prepuce, Inflammation, Chronic, | | |
Focal, Necrotizing | | 1 4.0|
Prepuce, Inflammation, Focal, | | |
Granulomatous, Necrotizing | | 2 3.0|
Thoracic, Inflammation, Chronic | | |
Active, Diffuse | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + M + + + + + + + + M +| 39 |
Hyperostosis | | 1 3.0|
Bilateral, Joint, Tarsal, Arthrosis, | | |
Chronic | 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2| 33 2.2|
Bilateral, Joint, Tarsal, Metaplasia,| | |
Diffuse, Osseous | 2| 1 2.0|
Joint, Tarsal, Arthrosis, Chronic | | 1 2.0|
Joint, Phalanges, Inflammation, | | |
Chronic Active, Focal | | 1 3.0|
Unilateral, Joint, Tarsal, Arthrosis,| | |
Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 1 |
Hemorrhage, Acute, Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 4 |
Infarct, Acute, Multifocal | | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Hyperplasia, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 6 |
Inflammation, Multifocal, Subacute | | 1 3.0|
Bilateral, Infarct, Acute, Multifocal| | 1 4.0|
Bilateral, Inflammation, Acute, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 6| 7| 6| 7| 7| 7| 7| 5| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 5| 4| 8| 3| 1| 3| 6| 3| 3| 3| 3| 1| 8| |
| 8| 0| 0| 0| 0| 0| 5| 0| 0| 0| 0| 0| 1| 7| 1| 0| 0| 0| 8| 0| 0| 0| 0| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
5000 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Multifocal, Suppurative | 3 | 1 3.0|
Corticomedullary Junction, Renal | | |
Tubule, Mineralization, | | |
Multifocal | | 1 2.0|
Pelvis, Inflammation, Acute, Diffuse | | 1 2.0|
Renal Tubule, Dilatation, Diffuse | 2 | 2 2.0|
Renal Tubule, Necrosis, Acute, | | |
Diffuse | 1 | 1 1.0|
Right, Atrophy | 4 | 1 4.0|
Right, Inflammation, Chronic Active, | | |
Diffuse | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urethra | + | 2 |
Concretion, Focal | 3 | 2 3.0|
Transitional Epithelium, Necrosis, | | |
Acute, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + | 3 |
Calculus Gross Observation | | 1 |
Lumen, Ectasia | 3 | 2 3.0|
Submucosa, Inflammation, Acute, | | |
Diffuse | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 7| 4| 4|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 1| 1| 2| 1| 1|
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10000 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + A + + + + + A + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + A + + + + + + + + + +|
Colon, Parasite Metazoan, Single | 1 |
__________________________________________________________________________|
Intestine Large, Cecum | M M M M|
__________________________________________________________________________|
Intestine Large, Colon | + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M M M M|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + A + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | M M M|
__________________________________________________________________________|
Intestine Small, Ileum | M M M|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + A + + + + + + + + + +|
Basophilic Focus, Multiple | X |
Basophilic Focus, Single | X X |
Inflammation, Multifocal, Subacute | |
Hepatocyte, Necrosis, Acute, Diffuse | 1 2 2 |
Hepatocyte, Necrosis, Acute, Focal | |
Hepatocyte, Nuclear Alteration, Focal| 2 1 1 1 1 1 1 |
Hepatocyte, Syncytial Alteration, | |
Diffuse | 3 2 2 1 2 2 1 2 3 3 2 2 1 1 2 2 2 2 1 1 2|
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + |
Fat, Necrosis, Acute, Diffuse | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +|
Acinus, Atrophy, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periductular, Infiltration Cellular, | |
Multifocal, Lymphocyte | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + A + + + + + + + + + +|
Forestomach, Epithelium, Hyperplasia,| |
Focal | 4 4 |
Glandular, Inflammation, Acute, Focal| |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + |
Peridontal Tissue, Inflammation, | |
Acute, Focal | 2 |
Peridontal Tissue, Inflammation, | |
Acute, Multifocal | 3 |
Peridontal Tissue, Inflammation, | |
Chronic Active, Multifocal | 2 3 |
Peridontal Tissue, Inflammation, | |
Focal, Subacute | |
Pulp, Inflammation, Acute, Focal, | |
Necrotizing | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 7| 4| 4|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 1| 1| 2| 1| 1|
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10000 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Pulp, Necrosis, Acute, Diffuse | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Acute, | |
Focal, Suppurative | |
Myocardium, Inflammation, Acute, | |
Multifocal | |
Myocardium, Inflammation, Multifocal,| |
Subacute | |
Ventricle Right, Necrosis, Chronic, | |
Focal | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + A + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Accessory Adrenal Cortical Nodule, | |
Focal | |
Cortex, Focal Cellular Change | X X |
Cortex, Focal Cellular Change, | |
Multifocal | X X |
Cortex, Hyperplasia, Focal | |
Cortex, Hypertrophy | 3 2 |
Medulla, Hyperplasia, Focal | 2 |
Spindle Cell, Hyperplasia, Focal | 2 |
Spindle Cell, Hyperplasia, Multifocal| 2 2 3 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + M + + + + + + + M + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + I + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Inflammation, Acute, | |
Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + + + + +|
Follicle, Cyst, Multiple | X |
Follicle, Cyst, Single | X X |
Follicular Cell, Hyperplasia, | |
Multifocal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 7| 4| 4|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 1| 1| 2| 1| 1|
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10000 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Inflammation, Diffuse, | |
Necrotizing | |
__________________________________________________________________________|
Penis | |
Inflammation, Acute, Focal | |
__________________________________________________________________________|
Preputial Gland | + + + +|
Abscess, Chronic, Focal | 4 |
Abscess, Focal, Subacute | 3|
Duct, Ectasia, Focal | 3 3 |
Duct, Ectasia, Multifocal | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation, Diffuse | |
Dilatation | |
Granuloma, Focal | |
Inflammation, Acute, Diffuse | |
Inflammation, Acute, Multifocal | |
Inflammation, Acute, Multifocal, | |
Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + |
Dilatation | |
Lumen, Dilatation, Diffuse | |
Lumen, Dilatation | |
Parenchyma, Inflammation, Acute, | |
Multifocal | |
Serosa, Inflammation, Acute, Diffuse | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy, Diffuse| 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
Neutrophilia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Diffuse, | |
Neutrophil | 3 |
Femoral, Thrombosis, Focal, Subacute | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + A + + + + + + M + + +|
Mandibular, Depletion Lymphoid, | |
Diffuse | 2 3 |
Mandibular, Hyperplasia, Diffuse, | |
Lymphoid | 2 |
Mandibular, Infiltration Cellular, | |
Diffuse, Plasma Cell | 2 |
Mediastinal, Depletion Lymphoid, | |
Diffuse | 2 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 7| 4| 4|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 1| 1| 2| 1| 1|
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10000 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesenteric, Angiectasis, Diffuse | 2 |
Mesenteric, Angiectasis, Multifocal | |
Mesenteric, Inflammation, Chronic | |
Pancreatic, Angiectasis, Diffuse | |
__________________________________________________________________________|
Lymph Node, Bronchial | M M M|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M|
__________________________________________________________________________|
Lymph Node, Mesenteric | M M M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Multifocal | |
Lymphoid Follicle, Depletion | |
Lymphoid, Multifocal | 2 2 2|
Lymphoid Follicle, Hyperplasia, | |
Diffuse | |
Lymphoid Follicle, Necrosis, Acute, | |
Multifocal | 2 |
Red Pulp, Angiectasis, Multifocal | 1 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Diffuse | 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + M + + M + M + + + + + + + +|
Depletion Lymphoid, Diffuse | 2 |
Cortex, Cyst, Single | X |
Medulla, Cyst, Multiple | X |
Thymocyte, Necrosis, Acute, Diffuse | 4 4 4 4|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Acute, Diffuse | 3 |
Abdominal, Inflammation, Chronic, | |
Focal | |
Abdominal, Ulcer, Acute, Focal | |
Abdominal, Ulcer, Acute, Multifocal | 3 |
Back, Acanthosis, Focal | 2 |
Back, Fibrosis, Focal | 2 3 |
Back, Fibrosis, Multifocal | 3 |
Back, Ulcer, Acute, Focal | 2 |
Back, Ulcer, Acute, Multifocal | 2 |
Back, Ulcer, Chronic Active, | |
Multifocal | |
Face, Subcutaneous Tissue, Granuloma,| |
Focal | 2 |
Hindlimb, Subcutaneous Tissue, | |
Inflammation, Chronic, Focal, | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 7| 4| 4|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 1| 1| 2| 1| 1|
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10000 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Granulomatous | 3 |
Prepuce, Inflammation, Acute, | |
Multifocal | |
Prepuce, Inflammation, Chronic, | |
Focal, Necrotizing | |
Prepuce, Inflammation, Chronic | |
Active, Focal | |
Subcutaneous Tissue, Granuloma, Focal| 2|
Subcutaneous Tissue, Granuloma, | |
Multiple | 1 |
Subcutaneous Tissue, Inflammation, | |
Acute, Diffuse | 2 |
Subcutaneous Tissue, Inflammation, | |
Acute, Focal | |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | |
Subcutaneous Tissue, Inflammation, | |
Focal, Granulomatous | 2 |
Thoracic, Inflammation, Chronic | |
Active, Focal | |
Thoracic, Ulcer, Chronic Active, | |
Multifocal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | X |
Bilateral, Joint, Tarsal, Arthrosis, | |
Chronic | 2 2 2 3 3 3 3 3 3 2 |
Bilateral, Joint, Tarsal, Metaplasia,| |
Multifocal, Osseous | |
Joint, Left, Tarsal, Metaplasia, | |
Multifocal, Osseous | |
Unilateral, Joint, Tarsal, Arthrosis,| |
Chronic | 3 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Inflammation, Acute, Focal | |
Fourth Ventricle, Lateral Ventricle, | |
Hydrocephalus | 3 |
Lateral Ventricle, Hydrocephalus | 2 |
Thalamus, Mineralization | 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 7| 4| 4|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 1| 1| 2| 1| 1|
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10000 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema, Multifocal, Subacute | 2 |
Foreign Body, Multifocal | 1 2 2 2|
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 2 |
Diaphragmatic Lobe, Right, Edema, | |
Focal, Subacute | 2 |
Interstitium, Infiltration Cellular, | |
Acute, Diffuse, | |
Polymorphonuclear | |
Interstitium, Inflammation, Acute, | |
Diffuse | |
Interstitium, Inflammation, Acute, | |
Multifocal | |
Mediastinum, Infiltration Cellular, | |
Multifocal, Lymphocyte | 3 |
Peribronchial, Infiltration Cellular,| |
Multifocal, Lymphocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + M M + M M|
Septum, Inflammation, Acute, Focal | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + |
Bilateral, Hyperplasia, Multifocal | 2 |
Right, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Multifocal | |
Inflammation, Chronic, Focal | |
Bilateral, Inflammation, Acute, | |
Multifocal, Suppurative | |
Bilateral, Inflammation, Chronic, | |
Multifocal | |
Cortex, Metaplasia, Focal, Osseous | |
Cortex, Renal Tubule, Necrosis, | |
Acute, Multifocal | 2 |
Corticomedullary Junction, | |
Metaplasia, Focal, Osseous | |
Corticomedullary Junction, | |
Mineralization, Multifocal | |
Pelvis, Inflammation, Acute, | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 4| 7| 4| 4|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 1| 1| 2| 1| 1|
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10000 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Multifocal, Suppurative | |
Pelvis, Mineralization, Focal | 2 |
Renal Tubule, Cytoplasmic Alteration,| |
Multifocal | |
Renal Tubule, Dilatation, Diffuse | |
Renal Tubule, Regeneration, Focal | 1 1 2 |
Renal Tubule, Regeneration, | |
Multifocal | 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Necrosis, Focal, Single | |
Serosa, Inflammation, Acute, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 1| 2| 4| 5| 7| 5| 7| 7| 7| 7| 3| 3| 7| 6| 7| 7| 3| 7| 3| 2| 6| 4| |
DAY ON TEST | 2| 2| 2| 7| 6| 8| 3| 2| 8| 2| 2| 2| 2| 1| 9| 2| 0| 2| 2| 9| 2| 7| 7| 6| 1| |
| 7| 7| 7| 1| 5| 3| 7| 7| 9| 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 2| 7| 5| 4| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
10000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + A A A + + + + + + A + + M + + A + + A + +| 40 |
__________________________________________________________________________|____________|
Intestine Large | + + + + A A + + + + + + + + + + M + + + + + A + +| 45 |
Colon, Parasite Metazoan, Single | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | M M + M M M M| 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + +| 11 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M M M M M M M| |
__________________________________________________________________________|____________|
Intestine Small | + + + A A A A + + + + + + A + + M + + + + + A + +| 41 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | M M M M| |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M M M| 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + +| 7 |
__________________________________________________________________________|____________|
Liver | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
Basophilic Focus, Multiple | | 1 |
Basophilic Focus, Single | | 2 |
Inflammation, Multifocal, Subacute | 2 | 1 2.0|
Hepatocyte, Necrosis, Acute, Diffuse | | 3 1.7|
Hepatocyte, Necrosis, Acute, Focal | 2 | 1 2.0|
Hepatocyte, Nuclear Alteration, Focal| 1 2 1 1 1 1 1 1 1 1 1 | 18 1.1|
Hepatocyte, Syncytial Alteration, | | |
Diffuse | 1 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 1| 42 1.8|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + + +| 37 |
Fat, Necrosis, Acute, Diffuse | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + M M + + + + + + + + + + M + + + + + M + +| 45 |
Acinus, Atrophy, Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Periductular, Infiltration Cellular, | | |
Multifocal, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + A A + + + + + + + + + + + + + + + + A + +| 46 |
Forestomach, Epithelium, Hyperplasia,| | |
Focal | 3 4 | 4 3.8|
Glandular, Inflammation, Acute, Focal| 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + | 34 |
Peridontal Tissue, Inflammation, | | |
Acute, Focal | | 1 2.0|
Peridontal Tissue, Inflammation, | | |
Acute, Multifocal | | 1 3.0|
Peridontal Tissue, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 1| 2| 4| 5| 7| 5| 7| 7| 7| 7| 3| 3| 7| 6| 7| 7| 3| 7| 3| 2| 6| 4| |
DAY ON TEST | 2| 2| 2| 7| 6| 8| 3| 2| 8| 2| 2| 2| 2| 1| 9| 2| 0| 2| 2| 9| 2| 7| 7| 6| 1| |
| 7| 7| 7| 1| 5| 3| 7| 7| 9| 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 2| 7| 5| 4| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
10000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Chronic Active, Multifocal | | 2 2.5|
Peridontal Tissue, Inflammation, | | |
Focal, Subacute | 2 | 1 2.0|
Pulp, Inflammation, Acute, Focal, | | |
Necrotizing | 3 | 1 3.0|
Pulp, Necrosis, Acute, Diffuse | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myocardium, Inflammation, Acute, | | |
Focal, Suppurative | 3 | 1 3.0|
Myocardium, Inflammation, Acute, | | |
Multifocal | 1 | 1 1.0|
Myocardium, Inflammation, Multifocal,| | |
Subacute | 2 | 1 2.0|
Ventricle Right, Necrosis, Chronic, | | |
Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + A A + + + + + + + + M + M + + + + + + + +| 45 |
Accessory Adrenal Cortical Nodule | X| 1 |
Accessory Adrenal Cortical Nodule, | | |
Focal | X | 1 |
Cortex, Focal Cellular Change | X X | 4 |
Cortex, Focal Cellular Change, | | |
Multifocal | | 2 |
Cortex, Hyperplasia, Focal | 2 | 1 2.0|
Cortex, Hypertrophy | 3 | 3 2.7|
Medulla, Hyperplasia, Focal | | 1 2.0|
Spindle Cell, Hyperplasia, Focal | | 1 2.0|
Spindle Cell, Hyperplasia, Multifocal| 2 | 5 2.2|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + +| 9 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + +| 9 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M M + + + + + + + + + + M + + + + + M + +| 45 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M M M + + M + M M M + + M + + + M + + + + M| 35 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + A + + + + + + + + + + + + + + + + M + +| 47 |
Pars Distalis, Inflammation, Acute, | | |
Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 1| 2| 4| 5| 7| 5| 7| 7| 7| 7| 3| 3| 7| 6| 7| 7| 3| 7| 3| 2| 6| 4| |
DAY ON TEST | 2| 2| 2| 7| 6| 8| 3| 2| 8| 2| 2| 2| 2| 1| 9| 2| 0| 2| 2| 9| 2| 7| 7| 6| 1| |
| 7| 7| 7| 1| 5| 3| 7| 7| 9| 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 2| 7| 5| 4| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
10000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicle, Cyst, Multiple | X | 2 |
Follicle, Cyst, Single | | 2 |
Follicular Cell, Hyperplasia, | | |
Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Epididymis | + + + + + M + + + + + + + + + + M + + + + + + + +| 48 |
Epithelium, Inflammation, Diffuse, | | |
Necrotizing | 2 | 1 2.0|
__________________________________________________________________________|____________|
Penis | + + | 2 |
Inflammation, Acute, Focal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 9 |
Abscess, Chronic, Focal | | 1 4.0|
Abscess, Focal, Subacute | | 1 3.0|
Duct, Ectasia, Focal | | 2 3.0|
Duct, Ectasia, Multifocal | 3 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Dilatation, Diffuse | 3 | 1 3.0|
Dilatation | 3 | 1 3.0|
Granuloma, Focal | 3 | 1 3.0|
Inflammation, Acute, Diffuse | 3 | 1 3.0|
Inflammation, Acute, Multifocal | 3 2 3 3 3 | 5 2.8|
Inflammation, Acute, Multifocal, | | |
Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + +| 15 |
Dilatation | 3 4 X | 3 3.5|
Lumen, Dilatation, Diffuse | 3 | 1 3.0|
Lumen, Dilatation | 3 3| 2 3.0|
Parenchyma, Inflammation, Acute, | | |
Multifocal | 2 | 1 2.0|
Serosa, Inflammation, Acute, Diffuse | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + M + + + + + + + + + + M + + + + + + + +| 48 |
Germinal Epithelium, Atrophy, Diffuse| | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 1| 2| 4| 5| 7| 5| 7| 7| 7| 7| 3| 3| 7| 6| 7| 7| 3| 7| 3| 2| 6| 4| |
DAY ON TEST | 2| 2| 2| 7| 6| 8| 3| 2| 8| 2| 2| 2| 2| 1| 9| 2| 0| 2| 2| 9| 2| 7| 7| 6| 1| |
| 7| 7| 7| 1| 5| 3| 7| 7| 9| 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 2| 7| 5| 4| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
10000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + | 6 |
Neutrophilia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Bone Marrow | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Femoral, Hyperplasia, Diffuse, | | |
Neutrophil | | 1 3.0|
Femoral, Thrombosis, Focal, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 |
Mandibular, Depletion Lymphoid, | | |
Diffuse | 3 2 | 4 2.5|
Mandibular, Hyperplasia, Diffuse, | | |
Lymphoid | | 1 2.0|
Mandibular, Infiltration Cellular, | | |
Diffuse, Plasma Cell | | 1 2.0|
Mediastinal, Depletion Lymphoid, | | |
Diffuse | | 1 2.0|
Mesenteric, Angiectasis, Diffuse | 2 2 | 3 2.0|
Mesenteric, Angiectasis, Multifocal | 2 | 1 2.0|
Mesenteric, Inflammation, Chronic | 4 | 1 4.0|
Pancreatic, Angiectasis, Diffuse | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + +| 9 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + M A + + + + + + + + + + M + + + + + + + +| 47 |
Inflammation, Acute, Multifocal | 1 | 1 1.0|
Lymphoid Follicle, Depletion | | |
Lymphoid, Multifocal | 2 2 2 3 3 2 2| 10 2.2|
Lymphoid Follicle, Hyperplasia, | | |
Diffuse | 3 | 1 3.0|
Lymphoid Follicle, Necrosis, Acute, | | |
Multifocal | | 1 2.0|
Red Pulp, Angiectasis, Multifocal | | 1 1.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Diffuse | 2 | 3 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + M M + M + + + + + M + + M M + M + + M + +| 38 |
Depletion Lymphoid, Diffuse | 3 | 2 2.5|
Cortex, Cyst, Single | | 1 |
Medulla, Cyst, Multiple | | 1 |
Thymocyte, Necrosis, Acute, Diffuse | 4 3 3 2| 8 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 1| 2| 4| 5| 7| 5| 7| 7| 7| 7| 3| 3| 7| 6| 7| 7| 3| 7| 3| 2| 6| 4| |
DAY ON TEST | 2| 2| 2| 7| 6| 8| 3| 2| 8| 2| 2| 2| 2| 1| 9| 2| 0| 2| 2| 9| 2| 7| 7| 6| 1| |
| 7| 7| 7| 1| 5| 3| 7| 7| 9| 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 2| 7| 5| 4| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
10000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Necrosis, Acute, Diffuse | | 1 3.0|
Abdominal, Inflammation, Chronic, | | |
Focal | 2 | 1 2.0|
Abdominal, Ulcer, Acute, Focal | 2 | 1 2.0|
Abdominal, Ulcer, Acute, Multifocal | 2 | 2 2.5|
Back, Acanthosis, Focal | 2 | 2 2.0|
Back, Fibrosis, Focal | 2 2 2 | 5 2.2|
Back, Fibrosis, Multifocal | | 1 3.0|
Back, Ulcer, Acute, Focal | 3 | 2 2.5|
Back, Ulcer, Acute, Multifocal | | 1 2.0|
Back, Ulcer, Chronic Active, | | |
Multifocal | 3 | 1 3.0|
Face, Subcutaneous Tissue, Granuloma,| | |
Focal | | 1 2.0|
Hindlimb, Subcutaneous Tissue, | | |
Inflammation, Chronic, Focal, | | |
Granulomatous | | 1 3.0|
Prepuce, Inflammation, Acute, | | |
Multifocal | 3 | 1 3.0|
Prepuce, Inflammation, Chronic, | | |
Focal, Necrotizing | 3 | 1 3.0|
Prepuce, Inflammation, Chronic | | |
Active, Focal | 2 | 1 2.0|
Subcutaneous Tissue, Granuloma, Focal| | 1 2.0|
Subcutaneous Tissue, Granuloma, | | |
Multiple | | 1 1.0|
Subcutaneous Tissue, Inflammation, | | |
Acute, Diffuse | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Acute, Focal | 1 | 1 1.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic, Focal | 1 | 1 1.0|
Subcutaneous Tissue, Inflammation, | | |
Focal, Granulomatous | 2 1 | 3 1.7|
Thoracic, Inflammation, Chronic | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 1| 2| 4| 5| 7| 5| 7| 7| 7| 7| 3| 3| 7| 6| 7| 7| 3| 7| 3| 2| 6| 4| |
DAY ON TEST | 2| 2| 2| 7| 6| 8| 3| 2| 8| 2| 2| 2| 2| 1| 9| 2| 0| 2| 2| 9| 2| 7| 7| 6| 1| |
| 7| 7| 7| 1| 5| 3| 7| 7| 9| 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 2| 7| 5| 4| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
10000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Active, Focal | 2 | 1 2.0|
Thoracic, Ulcer, Chronic Active, | | |
Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | | 1 |
Bilateral, Joint, Tarsal, Arthrosis, | | |
Chronic | 3 2 3 2 3 2 2 3 | 18 2.6|
Bilateral, Joint, Tarsal, Metaplasia,| | |
Multifocal, Osseous | 2 | 1 2.0|
Joint, Left, Tarsal, Metaplasia, | | |
Multifocal, Osseous | 2 | 1 2.0|
Unilateral, Joint, Tarsal, Arthrosis,| | |
Chronic | 2 2 | 11 2.1|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cerebrum, Inflammation, Acute, Focal | 2 | 1 2.0|
Fourth Ventricle, Lateral Ventricle, | | |
Hydrocephalus | | 1 3.0|
Lateral Ventricle, Hydrocephalus | | 1 2.0|
Thalamus, Mineralization | | 3 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema, Multifocal, Subacute | | 1 2.0|
Foreign Body, Multifocal | 2 | 5 1.8|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 3 2.3|
Diaphragmatic Lobe, Right, Edema, | | |
Focal, Subacute | | 1 2.0|
Interstitium, Infiltration Cellular, | | |
Acute, Diffuse, | | |
Polymorphonuclear | 2 | 1 2.0|
Interstitium, Inflammation, Acute, | | |
Diffuse | 2 | 1 2.0|
Interstitium, Inflammation, Acute, | | |
Multifocal | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 1| 2| 4| 5| 7| 5| 7| 7| 7| 7| 3| 3| 7| 6| 7| 7| 3| 7| 3| 2| 6| 4| |
DAY ON TEST | 2| 2| 2| 7| 6| 8| 3| 2| 8| 2| 2| 2| 2| 1| 9| 2| 0| 2| 2| 9| 2| 7| 7| 6| 1| |
| 7| 7| 7| 1| 5| 3| 7| 7| 9| 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 2| 7| 5| 4| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
10000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mediastinum, Infiltration Cellular, | | |
Multifocal, Lymphocyte | | 1 3.0|
Peribronchial, Infiltration Cellular,| | |
Multifocal, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + M M M M + M + + + + M M + M + + M + M M + M| 34 |
Septum, Inflammation, Acute, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + A A + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + | 30 |
Bilateral, Hyperplasia, Multifocal | | 1 2.0|
Right, Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Inflammation, Acute, Multifocal | 2 2 | 2 2.0|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Bilateral, Inflammation, Acute, | | |
Multifocal, Suppurative | 4 | 1 4.0|
Bilateral, Inflammation, Chronic, | | |
Multifocal | 3 | 1 3.0|
Cortex, Metaplasia, Focal, Osseous | 2 | 1 2.0|
Cortex, Renal Tubule, Necrosis, | | |
Acute, Multifocal | | 1 2.0|
Corticomedullary Junction, | | |
Metaplasia, Focal, Osseous | 1 | 1 1.0|
Corticomedullary Junction, | | |
Mineralization, Multifocal | 2 2 2 2 | 4 2.0|
Pelvis, Inflammation, Acute, | | |
Multifocal, Suppurative | 2 | 1 2.0|
Pelvis, Mineralization, Focal | | 1 2.0|
Renal Tubule, Cytoplasmic Alteration,| | |
Multifocal | 3 | 1 3.0|
Renal Tubule, Dilatation, Diffuse | 2 2| 2 2.0|
Renal Tubule, Regeneration, Focal | 1 | 4 1.3|
Renal Tubule, Regeneration, | | |
Multifocal | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + M A + + + + + + + + + + M + + + + + A + +| 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05052-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 1| 2| 4| 5| 7| 5| 7| 7| 7| 7| 3| 3| 7| 6| 7| 7| 3| 7| 3| 2| 6| 4| |
DAY ON TEST | 2| 2| 2| 7| 6| 8| 3| 2| 8| 2| 2| 2| 2| 1| 9| 2| 0| 2| 2| 9| 2| 7| 7| 6| 1| |
| 7| 7| 7| 1| 5| 3| 7| 7| 9| 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 2| 7| 5| 4| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
10000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Mucosa, Necrosis, Focal, Single | 1 | 1 1.0|
Serosa, Inflammation, Acute, | | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
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