TDMS Study 05052-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/08/94
EXP: 05052 2,4-DICHLOROPHENOL TIME: 00:06:25
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: C55345
CONT: N01-ES-38068 CAS: 120-83-2
PATHOLOGIST: S. EUSTIS G. DILL
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/08/94
EXP: 05052 2,4-DICHLOROPHENOL TIME: 00:06:25
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: C55345
CONT: N01-ES-38068 CAS: 120-83-2
PATHOLOGIST: S. EUSTIS G. DILL
2,4-DICHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 727 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 28 107 561 575 577 590 605 651 660 678 |
| 682 682 687 689 700 717 718 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 105 138 395 469 476 482 510 547 610 651 |
| 657 665 668 673 681 687 717 724 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 4 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 171 265 274 315 375 392 394 413 483 537 |
| 589 600 660 668 675 |
| CENSORED DEATHS |
| 416 416 416 416 |
| |
==================================================================================
2,4-DICHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 727 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 727 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 98.0 96.0 96.0 96.0 96.0 96.0 96.0 86.0 82.0 66.0 |
| | |
| | |
|5000 PPM | 100.0 96.0 96.0 96.0 94.0 88.0 86.0 84.0 76.0 64.0 |
| | |
| | |
|10000 PPM| 100.0 98.0 96.0 92.0 84.0 81.8 79.6 75.2 72.9 68.5 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 5000 PPM 10000 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 66.0% 64.0% 68.5% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.961 P=0.859 P=1.000 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 582.8 547.5 454.1 |
|NATURAL DEATHS (C) | (48.8) (43.2) (41.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 678.0 662.4 620.2 |
|(STANDARD ERROR) | (19.0) (19.6) (23.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
2,4-DICHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 5 CENSORED DEATHS 0 TERMINAL 45 |
| |
| UNCENSORED DEATHS |
| 567 577 668 679 689 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 269 508 521 542 595 616 623 651 678 690 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 7 CENSORED DEATHS 0 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 242 274 445 549 612 616 697 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
2,4-DICHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 728 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 96.0 96.0 90.0 |
| | |
| | |
|5000 PPM | 100.0 100.0 98.0 98.0 98.0 98.0 92.0 90.0 84.0 80.0 |
| | |
| | |
|10000 PPM| 100.0 100.0 98.0 96.0 96.0 94.0 94.0 92.0 88.0 86.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 5000 PPM 10000 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 90.0% 80.0% 86.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.623 P=0.236 P=0.708 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 636.0 569.3 490.7 |
|NATURAL DEATHS (C) | (26.4) (38.8) (66.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 718.8 696.3 694.8 |
|(STANDARD ERROR) | ( 4.6) (11.7) (14.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
2,4-DICHLOROPHENOL
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
5000 PPM = 2
10000 PPM = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 3
|
| 1 21 2 3 3
| 1 2 3 3 2 1
95 +
| 3 3 2 2 1 1
| 3 3 22
|
P 90 + 3 3 22 1 1
E |
R | 33 2 2 1 1
C | 3 3 2 2 1 1
E 85 +
N | 3 3 2 2 1 1
T | 2 2 1 1
| 3 3
S 80 + 3 3 22 11
U |
R | 33 2 2
V | 22 11
I 75 + 3 3
V | 22
A | 332211
L | 33
70 + 221 1
| 3 3
| 2 2
| 11
65 +
| 2
|
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 4 obs hidden.
2,4-DICHLOROPHENOL
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
5000 PPM = 2
10000 PPM = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 1
|
|
|
98 + 3 23 2 1 1
|
|
|
96 + 3 3 2 2 1 1
|
|
|
P 94 + 3 2 23 11
E |
R |
C |
E 92 + 23 2 3 1 1
N |
T |
|
S 90 + 2 2 1 1
U |
R |
V |
I 88 + 22 3
V |
A |
L |
86 + 2 2 3 3
|
|
|
84 + 2 2
|
|
|
82 + 2 2
|
|
|
80 + 2 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 3 obs hidden.
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