TDMS Study 05052-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
2,4-DICHLOROPHENOL
NTP Experiment-Test: 05052-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/07/94
Route: DOSED FEED Time: 20:09:14
Facility: Battelle Columbus Laboratory
Chemical CAS #: 120-83-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:09:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 14 3 8
Dead 2 4 2
Survivors
Terminal Sacrifice 34 43 40
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large (48) (49)
Colon, Parasite Metazoan, Single 1 (2%)
Rectum, Parasite Metazoan 2 (4%)
Rectum, Parasite Metazoan, Multifocal 1 (2%)
Rectum, Parasite Metazoan, Single 2 (4%)
Intestine Small (48) (49)
Ileum, Peyer's Patch, Hyperplasia, Lymphoid,
Multifocal 1 (2%)
Liver (50) (23) (50)
Angiectasis, Focal 1 (2%)
Angiectasis, Multifocal 1 (4%) 1 (2%)
Basophilic Focus, Multiple 33 (66%) 14 (61%) 42 (84%)
Basophilic Focus, Single 2 (4%) 2 (9%) 1 (2%)
Clear Cell Focus 2 (9%)
Clear Cell Focus, Multiple 1 (2%)
Clear Cell Focus, Single 2 (4%) 3 (6%)
Cyst 1 (4%)
Hemorrhage, Acute, Multifocal 1 (2%)
Hyperplasia, Focal 1 (2%)
Inflammation, Focal, Granulomatous 2 (9%)
Inflammation, Focal, Membranoproliferative 1 (2%)
Inflammation, Granulomatous, Multifocal 26 (52%) 7 (30%) 22 (44%)
Inflammation, Multifocal, Subacute 2 (9%)
Bile Duct, Hyperplasia, Multifocal 8 (16%) 2 (9%) 7 (14%)
Centrilobular, Pigmentation, Hemosiderin,
Multifocal 1 (2%)
Hepatocyte, Degeneration, Cystic, Focal 1 (2%) 3 (13%)
Hepatocyte, Necrosis, Acute, Multifocal 3 (6%) 1 (2%)
Hepatocyte, Necrosis, Multifocal 2 (4%)
Hepatocyte, Vacuolization Cytoplasmic,
Multifocal 9 (18%) 6 (12%)
Hepatocyte, Centrilobular, Necrosis,
Multifocal, Subacute 1 (2%)
Left Lateral Lobe, Angiectasis, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:09:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Median Lobe, Atrophy, Chronic, Multifocal 1 (2%)
Periportal, Hematopoietic Cell Proliferation,
Multifocal 2 (4%)
Periportal, Infiltration Cellular, Acute,
Multifocal, Lymphocyte 1 (2%)
Sinusoid, Subserosa, Congestion, Acute,
Multifocal 1 (2%)
Mesentery (2) (2)
Inflammation, Chronic, Multifocal 1 (50%)
Inflammation, Focal, Granulomatous 1 (50%)
Inflammation, Granulomatous, Multifocal 1 (50%)
Pancreas (50) (48) (49)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%)
Acinus, Atrophy, Focal 5 (10%) 10 (21%) 2 (4%)
Acinus, Atrophy, Multifocal 15 (30%) 8 (17%) 6 (12%)
Stomach (49) (50)
Forestomach, Hyperkeratosis, Multifocal 1 (2%)
Forestomach, Hyperplasia, Multifocal,
Squamous 1 (2%)
Glandular, Ulcer, Acute, Multifocal 1 (2%)
Tooth (1)
Peridontal Tissue, Inflammation, Chronic
Active, Multifocal 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50)
Atrium Left, Thrombosis, Multifocal, Subacute 1 (2%)
Myocardium, Degeneration, Chronic, Multifocal 40 (80%) 38 (76%)
Myocardium, Inflammation, Acute, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (49) (49)
Bilateral, Cortex, Atrophy, Diffuse 1 (2%)
Bilateral, Cortex, Congestion, Multifocal 1 (2%) 1 (2%)
Bilateral, Cortex, Congestion, Multifocal,
Subacute 1 (2%)
Bilateral, Cortex, Degeneration, Diffuse,
Fatty 1 (2%)
Bilateral, Cortex, Degeneration, Fatty,
Multifocal 3 (6%) 1 (2%)
Bilateral, Cortex, Hyperplasia, Focal 1 (2%)
Bilateral, Cortex, Hyperplasia, Multifocal 1 (2%) 7 (14%) 2 (4%)
Bilateral, Medulla, Hyperplasia, Multifocal 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:09:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Bilateral, Medulla, Infiltration Cellular,
Acute, Multifocal, Lymphocyte 1 (2%)
Capsule, Hyperplasia, Focal 1 (2%)
Cortex, Cyst 1 (2%)
Cortex, Cytoplasmic Alteration, Focal 3 (6%) 3 (6%) 1 (2%)
Cortex, Cytoplasmic Alteration, Multifocal 1 (2%)
Cortex, Degeneration, Cystic, Focal 1 (2%) 1 (2%)
Cortex, Degeneration, Fatty, Focal 12 (24%) 7 (14%) 6 (12%)
Cortex, Degeneration, Fatty, Multifocal 2 (4%) 1 (2%) 3 (6%)
Cortex, Hyperplasia, Focal 8 (16%) 6 (12%) 11 (22%)
Cortex, Hyperplasia, Multifocal 2 (4%) 3 (6%) 2 (4%)
Cortex, Hypertrophy, Focal 2 (4%) 1 (2%)
Cortex, Karyomegaly, Focal 3 (6%) 2 (4%)
Cortex, Necrosis, Multifocal 1 (2%)
Cortex, Right, Atrophy, Multifocal 1 (2%)
Medulla, Cyst 1 (2%)
Medulla, Hyperplasia, Focal 2 (4%) 2 (4%)
Medulla, Hyperplasia, Multifocal 1 (2%) 5 (10%)
Medulla, Karyomegaly, Focal 1 (2%)
Parathyroid Gland (36) (39)
Hyperplasia, Glandular, Multifocal 1 (3%)
Hyperplasia, Multifocal 1 (3%)
Pituitary Gland (50) (32) (48)
Cyst, Multiple 1 (3%)
Pars Distalis, Cyst 1 (2%) 3 (9%) 2 (4%)
Pars Distalis, Cyst, Multiple 12 (24%) 7 (22%) 6 (13%)
Pars Distalis, Cyst, Single 1 (2%) 1 (2%)
Pars Distalis, Hemorrhage, Focal 1 (2%) 1 (3%)
Pars Distalis, Hemorrhage, Multifocal 4 (8%) 4 (8%)
Pars Distalis, Hemorrhage, Multifocal,
Subacute 2 (4%)
Pars Distalis, Hyperplasia, Diffuse 1 (2%)
Pars Distalis, Hyperplasia, Focal 5 (10%) 1 (3%) 2 (4%)
Pars Distalis, Hyperplasia, Multifocal 2 (4%) 4 (8%)
Pars Distalis, Necrosis, Chronic, Multifocal 1 (3%)
Thyroid Gland (50) (49)
C-Cell, Hyperplasia, Focal 1 (2%)
C-Cell, Hyperplasia, Multifocal 30 (60%) 25 (51%)
Follicle, Cyst, Single 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:09:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (38) (2) (40)
Cyst 1 (3%)
Cyst, Multiple 2 (5%)
Hyperplasia, Focal, Glandular 3 (8%)
Inflammation, Chronic Active, Focal 1 (3%) 1 (3%)
Inflammation, Chronic Active, Multifocal 1 (3%)
Inflammation, Multifocal, Subacute 1 (3%)
Inflammation, Multifocal, Suppurative 1 (3%)
Necrosis, Acute, Focal 1 (3%)
Necrosis, Chronic Active, Focal 1 (3%)
Ovary (50) (5) (49)
Necrosis, Coagulative, Multifocal 1 (20%)
Bilateral, Periovarian Tissue, Cyst 1 (2%)
Bilateral, Follicle, Cyst 1 (2%)
Follicle, Cyst 2 (4%)
Follicle, Cyst, Multiple 1 (2%) 5 (10%)
Follicle, Cyst, Single 2 (4%)
Germinal Epithelium, Mineralization,
Multifocal 1 (2%)
Left, Follicle, Cyst 1 (2%)
Periovarian Tissue, Cyst 1 (2%) 1 (20%) 3 (6%)
Periovarian Tissue, Right, Cyst 1 (2%) 1 (20%)
Periovarian Tissue, Left, Cyst 2 (40%) 1 (2%)
Uterus (50) (10) (50)
Abscess 2 (4%)
Inflammation, Chronic Active, Multifocal 1 (2%)
Bilateral, Lumen, Ectasia 1 (10%)
Bilateral, Lumen, Ectasia, Multifocal 1 (2%)
Cervix, Diverticulum 2 (4%) 1 (10%) 1 (2%)
Cervix, Fibrosis, Chronic, Multifocal 1 (2%)
Cervix, Inflammation, Chronic Active,
Multifocal 1 (10%) 1 (2%)
Cervix, Inflammation, Multifocal, Suppurative 1 (2%)
Cervix, Prolapse, Multifocal 1 (10%)
Endometrium, Hemorrhage, Multifocal 1 (10%)
Endometrium, Hyperplasia, Cystic, Glandular,
Multifocal 24 (48%) 32 (64%)
Lumen, Ectasia, Focal 1 (2%)
Lumen, Ectasia, Multifocal 3 (6%) 5 (10%)
Lumen, Hemorrhage, Focal, Subacute 2 (20%)
Lumen, Right, Ectasia, Focal 1 (2%) 1 (10%)
Lumen, Right, Ectasia, Multifocal 1 (2%) 1 (10%) 1 (2%)
Lumen, Left, Ectasia, Focal 1 (2%)
Serosa, Inflammation, Chronic, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:09:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (12) (8)
Neutrophilia 1 (13%)
Bone Marrow (50) (49)
Hyperplasia, Multifocal, Neutrophil 1 (2%) 3 (6%)
Hyperplasia, Multifocal, Reticulum Cell 5 (10%)
Inflammation, Granulomatous, Multifocal 1 (2%)
Myelofibrosis, Multifocal 2 (4%)
Erythroid Cell, Hypoplasia, Multifocal 1 (2%)
Lymph Node (48) (47) (50)
Hemorrhage 1 (2%)
Inflammation, Granulomatous, Multifocal 1 (2%)
Cortex, Mandibular, Cyst, Multiple 1 (2%)
Mandibular, Angiectasis, Multifocal 1 (2%)
Mandibular, Depletion Lymphoid, Multifocal 1 (2%)
Mandibular, Hemorrhage, Multifocal 9 (19%) 5 (11%) 16 (32%)
Mandibular, Hyperplasia, Histiocytic,
Multifocal 1 (2%)
Mandibular, Hyperplasia, Lymphoid, Multifocal 5 (10%) 3 (6%)
Mandibular, Hyperplasia, Multifocal, Plasma
Cell 4 (8%) 8 (17%) 2 (4%)
Mandibular, Inflammation, Chronic, Multifocal 1 (2%) 4 (8%)
Mandibular, Inflammation, Granulomatous,
Multifocal 4 (8%) 7 (15%) 4 (8%)
Mandibular, Pigmentation, Hemosiderin,
Multifocal 1 (2%) 1 (2%)
Mediastinal, Depletion Lymphoid, Multifocal 1 (2%)
Mediastinal, Hemorrhage, Multifocal 6 (13%) 2 (4%)
Mediastinal, Inflammation, Chronic,
Multifocal 1 (2%)
Mediastinal, Inflammation, Granulomatous,
Multifocal 6 (13%) 4 (8%)
Spleen (50) (48) (50)
Lymphoid Follicle, Depletion Lymphoid,
Multifocal 2 (4%) 2 (4%) 1 (2%)
Lymphoid Follicle, Inflammation,
Granulomatous, Multifocal 2 (4%)
Red Pulp, Congestion, Focal 1 (2%) 1 (2%)
Red Pulp, Fibrosis, Focal 1 (2%)
Red Pulp, Hematopoietic Cell Proliferation,
Multifocal 25 (50%) 17 (35%) 30 (60%)
Red Pulp, Hematopoietic Cell Proliferation,
Multiple 1 (2%)
Red Pulp, Inflammation, Chronic Active,
Multifocal 1 (2%)
Red Pulp, Inflammation, Granulomatous,
Multifocal 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:09:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Red Pulp, Necrosis, Acute, Focal 1 (2%)
Red Pulp, Necrosis, Acute, Multifocal 1 (2%)
Red Pulp, Pigmentation, Hemosiderin,
Multifocal 2 (4%) 3 (6%) 2 (4%)
Thymus (39) (47)
Depletion Lymphoid, Multifocal 30 (77%) 36 (77%)
Pigmentation, Hemosiderin, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (46) (9) (46)
Acinus, Hyperplasia, Cystic, Multifocal 26 (57%) 27 (59%)
Acinus, Hyperplasia, Cystic, Multiple 1 (2%)
Skin (50) (2) (50)
Abdominal, Ulcer, Acute, Focal 1 (2%)
Axillary, Subcutaneous Tissue, Inflammation,
Chronic Active, Multifocal 1 (2%)
Hindlimb, Subcutaneous Tissue, Inflammation,
Chronic Active, Granulomatous 1 (50%)
Hindlimb, Epidermis, Acanthosis, Multifocal 1 (50%)
Hindlimb, Epidermis, Hyperkeratosis,
Multifocal 1 (50%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (50)
Femur, Osteopetrosis, Multifocal 7 (14%) 11 (22%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (48)
Cerebellum, Hemorrhage, Acute, Focal 1 (2%)
Cerebellum, Hemorrhage, Multifocal 1 (2%)
Cerebrum, Compression, Focal 9 (18%) 7 (15%)
Cerebrum, Hemorrhage, Focal 1 (2%)
Cerebrum, Perivascular Cuffing, Focal 1 (2%)
Medulla, Hemorrhage, Focal 1 (2%)
Medulla, Hemorrhage, Multifocal 1 (2%)
Ventricle, Hydrocephalus, Multifocal 3 (6%) 5 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:09:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (1) (50)
Congestion, Acute, Diffuse 1 (100%)
Congestion, Acute, Multifocal 2 (4%)
Hemorrhage, Acute, Multifocal 2 (4%)
Pigmentation, Hemosiderin, Multifocal 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 2 (4%)
Alveolar Epithelium, Hyperplasia, Multifocal 1 (2%)
Bronchiole, Epithelium, Hyperplasia,
Multifocal 1 (2%)
Interstitium, Inflammation, Acute, Focal 1 (2%)
Interstitium, Inflammation, Acute, Multifocal 1 (2%)
Interstitium, Inflammation, Chronic, Focal 1 (2%)
Interstitium, Inflammation, Multifocal,
Subacute 1 (2%)
Nose (45) (45)
Nasolacrimal Duct, Inflammation, Focal,
Subacute 5 (11%) 7 (16%)
Nasolacrimal Duct, Inflammation, Multifocal,
Subacute 18 (40%) 9 (20%)
Respiratory Epithelium, Degeneration,
Multifocal 19 (42%) 17 (38%)
Submucosa, Respiratory Epithelium,
Congestion, Acute, Multifocal 1 (2%)
Submucosa, Respiratory Epithelium,
Inflammation, Multifocal, Subacute 21 (47%) 24 (53%)
Trachea (49) (48)
Wall, Hemorrhage, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (1) (4)
Hemorrhage, Acute, Multifocal 1 (25%)
Lens, Cataract 1 (100%) 3 (75%)
Lens, Cataract, Multifocal 1 (25%)
Retina, Atrophy, Multifocal 1 (25%) 1 (100%) 3 (75%)
Harderian Gland (40) (42)
Inflammation, Focal, Subacute 2 (5%)
Inflammation, Multifocal, Subacute 15 (38%) 8 (19%)
Bilateral, Inflammation, Multifocal, Subacute 1 (3%) 2 (5%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:09:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (1) (49)
Bilateral, Nephropathy, Chronic, Multifocal 46 (92%) 33 (67%)
Bilateral, Nephropathy, Multifocal 1 (2%)
Cortex, Casts, Single 1 (2%)
Cortex, Infarct, Focal 1 (2%)
Cortex, Inflammation, Chronic, Focal 1 (2%) 1 (2%)
Cortex, Left, Cyst, Single 1 (100%) 1 (2%)
Medulla, Left, Cyst, Multiple 1 (2%)
Renal Tubule, Degeneration, Acute, Multifocal 2 (4%) 1 (2%)
Renal Tubule, Hyperplasia, Focal 1 (2%)
Renal Tubule, Vacuolization Cytoplasmic,
Multifocal 1 (2%)
Urinary Bladder (50) (1) (48)
Calculus Micro Observation Only 1 (2%)
Lumen, Calculus Gross Observation 1 (100%)
Mucosa, Hyperplasia, Chronic, Multifocal 1 (100%)
Mucosa, Hyperplasia, Multifocal 1 (2%)
Mucosa, Hyperplasia, Multifocal, Squamous 1 (2%)
Mucosa, Metaplasia, Multifocal, Squamous 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:09:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 12 16 12
Dead 5 9 6
Survivors
Terminal Sacrifice 33 25 32
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50)
Submucosa, Inflammation, Chronic, Multifocal 1 (2%)
Intestine Large (47) (1) (47)
Colon, Peyer's Patch, Hyperplasia, Lymphoid,
Multifocal 3 (6%)
Colon, Mesothelium, Inflammation, Chronic
Active, Multifocal 1 (100%)
Lamina Propria, Rectum, Inflammation,
Multifocal, Subacute 1 (100%)
Peyer's Patch, Rectum, Hyperplasia, Lymphoid,
Multifocal 1 (2%)
Rectum, Parasite Metazoan 1 (2%)
Rectum, Mesothelium, Inflammation, Chronic
Active, Multifocal 1 (100%)
Intestine Small (47) (1) (47)
Necrosis 1 (100%)
Jejunum, Inflammation, Chronic Active,
Multifocal, Proliferative 1 (100%)
Jejunum, Necrosis 1 (100%)
Jejunum, Lamina Propria, Metaplasia,
Multifocal, Osseous 1 (100%)
Jejunum, Subserosa, Diverticulum 1 (100%)
Mucosa, Necrosis 1 (100%)
Liver (50) (50) (50)
Angiectasis, Focal 4 (8%)
Angiectasis, Multifocal 1 (2%)
Basophilic Focus 1 (2%) 3 (6%)
Basophilic Focus, Focal 1 (2%)
Basophilic Focus, Multiple 14 (28%) 12 (24%) 11 (22%)
Basophilic Focus, Single 2 (4%) 2 (4%) 1 (2%)
Clear Cell Focus 1 (2%)
Clear Cell Focus, Focal 1 (2%)
Clear Cell Focus, Multiple 1 (2%) 1 (2%) 4 (8%)
Clear Cell Focus, Single 1 (2%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:09:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Eosinophilic Focus 2 (4%)
Eosinophilic Focus, Multiple 3 (6%) 3 (6%)
Eosinophilic Focus, Single 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Focal 1 (2%)
Inflammation, Granulomatous, Multifocal 5 (10%) 7 (14%) 2 (4%)
Mixed Cell Focus 1 (2%)
Bile Duct, Hyperplasia, Chronic, Multifocal 1 (2%)
Bile Duct, Hyperplasia, Cystic, Multifocal 1 (2%)
Bile Duct, Hyperplasia, Multifocal 35 (70%) 30 (60%) 23 (46%)
Bile Duct, Hyperplasia, Multifocal, Nodular 1 (2%)
Capsule, Hematocyst, Single 1 (2%)
Centrilobular, Necrosis, Acute, Multifocal 1 (2%)
Hepatocyte, Cytoplasmic Alteration, Focal 1 (2%) 2 (4%)
Hepatocyte, Cytoplasmic Alteration,
Multifocal 2 (4%)
Hepatocyte, Degeneration, Cystic, Focal 10 (20%) 7 (14%) 6 (12%)
Hepatocyte, Degeneration, Cystic, Multifocal 9 (18%) 5 (10%) 2 (4%)
Hepatocyte, Necrosis, Acute, Multifocal 2 (4%)
Hepatocyte, Necrosis, Focal 1 (2%)
Hepatocyte, Necrosis, Multifocal 1 (2%)
Hepatocyte, Necrosis, Multifocal, Subacute 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic, Focal 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic,
Multifocal 8 (16%) 8 (16%) 10 (20%)
Left Lateral Lobe, Necrosis, Acute, Focal 1 (2%)
Median Lobe, Hepatocyte, Degeneration, Fatty,
Multifocal 1 (2%)
Mesentery (3) (2) (2)
Inflammation, Granulomatous, Multifocal 1 (50%)
Necrosis, Chronic, Focal 1 (50%)
Fat, Necrosis 1 (50%)
Fat, Necrosis, Acute, Multifocal 1 (33%)
Fat, Necrosis, Chronic, Multifocal 1 (33%)
Pancreas (49) (49)
Acinus, Atrophy, Focal 2 (4%) 7 (14%)
Acinus, Atrophy, Multifocal 27 (55%) 16 (33%)
Acinus, Cytoplasmic Alteration, Focal 2 (4%)
Acinus, Cytoplasmic Alteration, Multifocal 1 (2%)
Artery, Inflammation, Chronic Active,
Multifocal 1 (2%)
Duct, Ectasia, Focal 1 (2%)
Duct, Ectasia, Multifocal 1 (2%) 1 (2%)
Salivary Glands (50) (50)
Acinus, Atrophy, Focal 1 (2%)
Acinus, Atrophy, Multifocal 1 (2%)
Stomach (49) (2) (49)
Forestomach, Acanthosis, Focal 1 (50%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:09:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Forestomach, Acanthosis, Multifocal 2 (4%)
Forestomach, Hyperkeratosis, Focal 1 (50%)
Forestomach, Hyperkeratosis, Multifocal 1 (2%)
Forestomach, Ulcer, Focal, Subacute 1 (2%)
Forestomach, Ulcer, Multifocal, Subacute 1 (2%)
Forestomach, Muscularis, Inflammation,
Chronic, Multifocal 1 (2%)
Forestomach, Muscularis, Mineralization,
Multifocal 1 (2%)
Glandular, Inflammation, Chronic, Multifocal 1 (2%)
Glandular, Necrosis, Acute, Focal 1 (2%)
Glandular, Necrosis, Acute, Multifocal 2 (100%) 1 (2%)
Glandular, Ulcer, Acute, Multifocal 1 (2%)
Glandular, Ulcer, Focal, Subacute 1 (2%)
Muscularis, Glandular, Mineralization,
Multifocal 1 (2%)
Submucosa, Glandular, Inflammation,
Multifocal, Subacute 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (2) (50)
Artery, Mineralization, Multifocal 1 (2%)
Atrium Left, Thrombosis 1 (2%)
Atrium Left, Thrombosis, Chronic 1 (50%)
Atrium Left, Thrombosis, Multiple, Subacute 1 (2%)
Atrium Left, Thrombosis, Single 2 (4%)
Myocardium, Degeneration, Chronic, Multifocal 46 (92%) 2 (100%) 44 (88%)
Myocardium, Degeneration, Multifocal 1 (2%) 1 (2%)
Myocardium, Inflammation, Chronic, Multifocal 1 (2%)
Myocardium, Mineralization, Multifocal 1 (2%) 1 (2%)
Ventricle Left, Thrombosis, Chronic, Focal 1 (2%)
Ventricle Left, Thrombosis, Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (3) (50)
Bilateral, Cortex, Hematopoietic Cell
Proliferation, Multifocal 1 (2%)
Bilateral, Cortex, Hyperplasia, Multifocal 3 (6%)
Bilateral, Cortex, Vacuolization Cytoplasmic,
Multifocal 1 (2%) 1 (2%)
Bilateral, Medulla, Hyperplasia, Multifocal 1 (2%)
Cortex, Congestion, Multifocal 1 (2%)
Cortex, Cytoplasmic Alteration, Focal 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:09:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Cortex, Degeneration, Fatty, Focal 5 (10%) 1 (33%) 6 (12%)
Cortex, Degeneration, Fatty, Multifocal 5 (10%) 1 (2%)
Cortex, Hematopoietic Cell Proliferation,
Multifocal 1 (2%)
Cortex, Hyperplasia, Focal 6 (12%) 5 (10%)
Cortex, Hyperplasia, Multifocal 1 (2%) 1 (2%)
Cortex, Karyomegaly, Focal 1 (2%)
Cortex, Necrosis, Multifocal 1 (2%)
Cortex, Nuclear Alteration, Focal 1 (2%)
Cortex, Vacuolization Cytoplasmic, Diffuse 1 (2%)
Cortex, Vacuolization Cytoplasmic, Multifocal 4 (8%)
Medulla, Cyst, Single 1 (2%)
Medulla, Hyperplasia, Focal 6 (12%) 10 (20%)
Medulla, Hyperplasia, Multifocal 6 (12%) 3 (6%)
Islets, Pancreatic (49) (49)
Hyperplasia, Focal 1 (2%)
Parathyroid Gland (42) (1) (44)
Cytoplasmic Alteration, Focal 1 (2%)
Hyperplasia, Diffuse 1 (2%)
Hyperplasia, Focal 1 (2%)
Hyperplasia, Multifocal 2 (5%) 2 (5%)
Pituitary Gland (49) (44) (49)
Pars Distalis, Cyst 1 (2%) 4 (9%)
Pars Distalis, Cyst, Multiple 1 (2%) 1 (2%)
Pars Distalis, Hemorrhage, Focal 1 (2%)
Pars Distalis, Hyperplasia, Focal 7 (14%) 7 (16%) 5 (10%)
Pars Distalis, Hyperplasia, Multifocal 5 (10%)
Pars Distalis, Karyomegaly, Multifocal 1 (2%)
Pars Intermedia, Cyst 2 (4%)
Pars Intermedia, Cyst, Multiple 2 (4%)
Pars Intermedia, Hemorrhage, Chronic, Focal 1 (2%)
Thyroid Gland (49) (49) (50)
Bilateral, Follicle, Cyst, Multiple 1 (2%)
C-Cell, Hyperplasia, Focal 6 (12%) 4 (8%) 6 (12%)
C-Cell, Hyperplasia, Multifocal 5 (10%) 5 (10%) 3 (6%)
Follicle, Cyst 1 (2%) 5 (10%)
Follicle, Cyst, Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:09:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (1) (50)
Bilateral, Inflammation, Chronic, Multifocal 1 (2%)
Bilateral, Inflammation, Multifocal, Subacute 1 (2%)
Head, Granuloma Sperm, Single 1 (100%)
Penis (1)
Inflammation, Acute, Multifocal, Necrotizing 1 (100%)
Preputial Gland (43) (3) (47)
Abscess 1 (2%)
Hyperplasia, Focal, Glandular 1 (2%)
Hyperplasia, Glandular, Multifocal 1 (2%)
Hyperplasia, Multifocal, Nodular, Squamous 1 (2%)
Infiltration Cellular, Mononuclear Cell,
Mononuclear Cell, Multifocal 1 (2%)
Inflammation, Chronic, Multifocal 1 (2%)
Inflammation, Chronic Active, Multifocal 4 (9%) 3 (6%)
Inflammation, Chronic Active, Multifocal,
Necrotizing 1 (2%)
Inflammation, Multifocal, Subacute 2 (5%)
Bilateral, Hyperplasia, Glandular, Multifocal 1 (2%)
Bilateral, Inflammation, Chronic Active,
Multifocal 27 (63%) 36 (77%)
Bilateral, Duct, Ectasia, Focal 1 (2%) 1 (2%)
Bilateral, Duct, Ectasia, Multifocal 6 (14%) 2 (4%)
Duct, Ectasia, Focal 3 (6%)
Duct, Ectasia, Multifocal 1 (2%) 1 (2%)
Duct, Right, Ectasia, Diffuse 1 (2%)
Prostate (48) (3) (50)
Dilatation, Multifocal 1 (33%)
Inflammation, Chronic, Multifocal 6 (13%) 3 (6%)
Inflammation, Chronic, Multifocal,
Suppurative 2 (4%)
Inflammation, Chronic Active, Multifocal 2 (67%) 2 (4%)
Inflammation, Focal, Subacute 1 (2%)
Inflammation, Granulomatous, Multifocal 1 (2%)
Inflammation, Multifocal, Subacute 2 (4%) 3 (6%)
Epithelium, Hyperplasia, Multifocal 1 (2%)
Serosa, Inflammation, Chronic, Multifocal 1 (2%)
Seminal Vesicle (1)
Dilatation, Multifocal 1 (100%)
Testes (50) (38) (50)
Atrophy, Multifocal 1 (2%)
Bilateral, Atrophy, Multifocal 1 (2%)
Bilateral, Interstitial Cell, Hyperplasia,
Multifocal 2 (4%) 4 (8%)
Bilateral, Seminiferous Tubule, Atrophy,
Chronic, Multifocal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:09:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Bilateral, Seminiferous Tubule, Atrophy,
Multifocal 27 (54%) 20 (53%) 20 (40%)
Interstitial Cell, Hyperplasia, Multifocal 4 (11%) 2 (4%)
Interstitial Cell, Right, Hyperplasia,
Multifocal 8 (16%) 3 (8%) 3 (6%)
Interstitial Cell, Left, Hyperplasia, Focal 1 (2%)
Interstitial Cell, Left, Hyperplasia,
Multifocal 5 (10%) 4 (11%) 2 (4%)
Interstitial Tissue, Hemorrhage, Chronic
Active, Multifocal 1 (3%)
Interstitial Tissue, Right, Hemorrhage,
Chronic Active, Multifocal 1 (3%)
Left, Atrophy, Multifocal 1 (3%)
Seminiferous Tubule, Atrophy, Multifocal 4 (8%) 4 (11%) 3 (6%)
Seminiferous Tubule, Right, Atrophy,
Multifocal 5 (10%) 4 (11%) 3 (6%)
Seminiferous Tubule, Left, Atrophy,
Multifocal 6 (12%) 3 (8%) 4 (8%)
Vein, Ectasia, Chronic, Multifocal 1 (3%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (26) (16)
Neutrophilia 2 (8%)
Bone Marrow (49) (50)
Hyperplasia, Multifocal, Neutrophil 4 (8%) 1 (2%)
Myelofibrosis, Multifocal 1 (2%)
Myeloid Cell, Erythroid Cell, Hypoplasia,
Diffuse 1 (2%)
Myeloid Cell, Erythroid Cell, Hypoplasia,
Multifocal 2 (4%)
Lymph Node (50) (9) (50)
Depletion Lymphoid, Multifocal 1 (2%)
Hyperplasia, Lymphoid, Multifocal 1 (2%)
Inguinal, Inflammation, Granulomatous,
Multifocal 1 (11%)
Lumbar, Inflammation, Granulomatous,
Multifocal 1 (11%)
Mandibular, Cyst 3 (6%) 1 (2%)
Mandibular, Depletion Lymphoid, Multifocal 1 (2%)
Mandibular, Hemorrhage, Multifocal 3 (6%) 5 (10%)
Mandibular, Hyperplasia, Lymphoid, Multifocal 6 (12%) 5 (10%)
Mandibular, Hyperplasia, Multifocal, Plasma
Cell 5 (10%)
Mandibular, Infiltration Cellular,
Multifocal, Plasma Cell 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:09:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Mandibular, Inflammation, Chronic, Multifocal 1 (2%) 1 (2%)
Mandibular, Inflammation, Granulomatous,
Multifocal 1 (2%)
Mediastinal, Hemorrhage, Multifocal 3 (6%) 4 (8%)
Mediastinal, Hyperplasia, Lymphoid,
Multifocal 1 (2%)
Mediastinal, Inflammation, Chronic,
Multifocal 1 (11%)
Mediastinal, Inflammation, Chronic Active,
Multifocal 1 (11%)
Mediastinal, Inflammation, Granulomatous,
Multifocal 1 (2%) 3 (6%)
Mediastinal, Inflammation, Multifocal,
Subacute 1 (2%)
Mediastinal, Pigmentation, Hemosiderin,
Multifocal 1 (11%)
Mesenteric, Cyst 1 (2%)
Mesenteric, Cyst, Multiple 1 (2%) 1 (2%)
Mesenteric, Hemorrhage, Multifocal 1 (2%) 1 (11%)
Mesenteric, Hyperplasia, Lymphoid, Multifocal 1 (2%)
Mesenteric, Inflammation, Chronic, Multifocal 1 (2%)
Mesenteric, Inflammation, Granulomatous,
Multifocal 1 (2%) 1 (11%)
Pancreatic, Cyst 1 (2%)
Pancreatic, Hemorrhage, Multifocal 2 (4%)
Spleen (50) (14) (50)
Necrosis, Diffuse, Subacute 1 (2%)
Capsule, Cyst, Multiple 1 (7%)
Lymphoid Follicle, Necrosis, Acute,
Multifocal 1 (2%)
Red Pulp, Fibrosis, Chronic, Focal 1 (7%)
Red Pulp, Fibrosis, Chronic, Multifocal 1 (2%) 1 (7%)
Red Pulp, Fibrosis, Focal 2 (4%) 1 (7%)
Red Pulp, Fibrosis, Multifocal 3 (6%) 1 (7%) 1 (2%)
Red Pulp, Hematopoietic Cell Proliferation,
Multifocal 2 (4%) 5 (10%)
Red Pulp, Pigmentation, Hemosiderin,
Multifocal 1 (2%) 2 (4%)
Thymus (39) (1) (43)
Depletion Lymphoid, Multifocal 30 (77%) 33 (77%)
Artery, Mediastinum, Inflammation, Chronic,
Multifocal, Proliferative 1 (3%)
Epithelial Cell, Hyperplasia, Multifocal 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:09:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (25) (4) (22)
Acinus, Hyperplasia, Cystic, Multifocal 19 (76%) 12 (55%)
Acinus, Hyperplasia, Multifocal 1 (4%) 2 (9%)
Skin (49) (12) (50)
Abdominal, Inflammation, Chronic, Focal,
Suppurative 1 (2%)
Abdominal, Subcutaneous Tissue, Edema,
Multifocal, Subacute 1 (2%)
Inguinal, Abscess 1 (2%)
Inguinal, Ulcer, Chronic Active, Focal 1 (2%)
Inguinal, Subcutaneous Tissue, Inflammation,
Chronic Active, Multifocal 1 (2%)
Tail, Hyperkeratosis, Multifocal 1 (2%)
Thoracic, Subcutaneous Tissue, Hemorrhage,
Chronic Active, Diffuse 1 (8%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (48)
Femur, Osteopetrosis, Multifocal 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (1) (50)
Cerebellum, Hemorrhage, Acute, Multifocal 1 (2%)
Cerebellum, Cerebrum, Hemorrhage, Multifocal 1 (100%)
Cerebrum, Hemorrhage, Acute, Multifocal 1 (2%)
Cerebrum, Hemorrhage, Focal 1 (2%)
Medulla, Cerebrum, Hemorrhage, Acute,
Multifocal 1 (2%)
Third Ventricle, Hemorrhage, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (3) (50)
Congestion, Acute, Diffuse 1 (2%)
Inflammation, Granulomatous, Multifocal 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia, Multifocal 2 (4%)
Bronchiole, Epithelium, Hyperplasia,
Multifocal 1 (2%)
Interstitium, Inflammation, Acute, Focal 2 (4%)
Interstitium, Inflammation, Chronic, Focal 1 (33%)
Interstitium, Inflammation, Chronic,
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:09:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Multifocal 6 (12%) 1 (2%)
Interstitium, Inflammation, Multifocal,
Subacute 1 (2%)
Interstitium, Metaplasia, Focal, Osseous 1 (2%)
Interstitium, Mineralization, Multifocal 1 (2%) 1 (33%)
Mediastinum, Inflammation, Granulomatous,
Multifocal 1 (2%)
Nose (45) (48) (46)
Degeneration, Multifocal 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic,
Multifocal 1 (2%)
Nasolacrimal Duct, Inflammation, Focal,
Subacute 4 (9%) 1 (2%) 6 (13%)
Nasolacrimal Duct, Inflammation, Multifocal 1 (2%)
Nasolacrimal Duct, Inflammation, Multifocal,
Subacute 20 (44%) 19 (40%) 11 (24%)
Respiratory Epithelium, Degeneration,
Multifocal 25 (56%) 38 (79%) 42 (91%)
Respiratory Epithelium, Inflammation,
Chronic, Focal 1 (2%)
Respiratory Epithelium, Inflammation,
Multifocal, Subacute 2 (4%)
Respiratory Epithelium, Metaplasia,
Multifocal, Squamous 2 (4%)
Submucosa, Olfactory Epithelium,
Inflammation, Multifocal, Subacute 1 (2%)
Submucosa, Respiratory Epithelium,
Concretion, Multifocal 1 (2%)
Submucosa, Respiratory Epithelium,
Inflammation, Acute, Focal 1 (2%)
Submucosa, Respiratory Epithelium,
Inflammation, Acute, Multifocal 1 (2%) 3 (6%) 1 (2%)
Submucosa, Respiratory Epithelium,
Inflammation, Chronic, Multifocal 4 (9%)
Submucosa, Respiratory Epithelium,
Inflammation, Chronic, Multifocal,
Suppurative 1 (2%)
Submucosa, Respiratory Epithelium,
Inflammation, Focal, Subacute 2 (4%) 1 (2%)
Submucosa, Respiratory Epithelium,
Inflammation, Multifocal 1 (2%)
Submucosa, Respiratory Epithelium,
Inflammation, Multifocal, Subacute 19 (42%) 23 (48%) 22 (48%)
Submucosa, Respiratory Epithelium,
Inflammation, Multifocal, Suppurative 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 18
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:09:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (4) (2)
Cornea, Inflammation, Multifocal, Subacute 1 (25%)
Lens, Cataract 1 (50%)
Lens, Cataract, Multifocal 2 (50%) 2 (50%)
Retina, Atrophy, Multifocal 3 (75%) 2 (50%) 1 (50%)
Harderian Gland (43) (36)
Hyperplasia, Focal, Glandular 1 (3%)
Hyperplasia, Glandular, Multifocal 1 (2%)
Inflammation, Granulomatous, Multifocal 1 (3%)
Inflammation, Multifocal, Subacute 3 (8%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (8) (49)
Congestion, Multifocal 1 (13%)
Cyst 1 (13%)
Cyst, Multiple 1 (2%)
Polycystic Kidney 1 (13%)
Bilateral, Nephropathy, Chronic, Multifocal 49 (98%) 6 (75%) 48 (98%)
Bilateral, Cortex, Cyst, Multiple 1 (13%)
Bilateral, Cortex, Mineralization, Multifocal 1 (13%)
Bilateral, Pelvis, Hydronephrosis, Multifocal 1 (13%)
Cortex, Cyst 3 (6%) 1 (13%)
Cortex, Cyst, Multiple 2 (4%)
Cortex, Cyst, Single 4 (8%)
Left, Nephropathy, Chronic, Multifocal 1 (2%)
Papilla, Epithelium, Hyperplasia, Multifocal 1 (2%)
Renal Tubule, Pigmentation, Multifocal 1 (2%)
Right, Cyst 1 (13%)
Urinary Bladder (48) (2) (50)
Inflammation, Acute, Hemorrhagic, Multifocal 1 (50%)
Mucosa, Hyperplasia, Multifocal 1 (2%) 1 (50%) 1 (2%)
Muscularis, Inflammation, Chronic Active,
Multifocal 1 (50%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 19
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 132950-132950/132950
--multipart-boundary--