TDMS Study 05052-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
2,4-DICHLOROPHENOL
NTP Experiment-Test: 05052-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/07/94
Route: DOSED FEED Time: 20:32:32
Facility: Battelle Columbus Laboratory
Chemical CAS #: 120-83-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:32:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund 14 3 8
Dead 2 4 2
Survivors
Terminal Sacrifice 34 43 40
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large (48) (49)
Intestine Small (48) (49)
Muscularis, Jejunum, Leiomyoma 1 (2%)
Liver (50) (23) (50)
Neoplastic Nodule 1 (4%)
Pancreas (50) (48) (49)
Pharynx (1)
Palate, Squamous Cell Papilloma 1 (100%)
Salivary Glands (50) (50)
Stomach (49) (50)
Tongue (1)
Mucosa, Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (49) (49)
Bilateral, Medulla, Pheochromocytoma Benign 1 (2%) 1 (2%)
Cortex, Adenoma 1 (2%)
Cortex, Carcinoma 1 (2%)
Medulla, Pheochromocytoma Benign 4 (8%) 3 (6%) 1 (2%)
Medulla, Pheochromocytoma Benign, Multiple 1 (2%)
Islets, Pancreatic (50) (2) (49)
Adenoma 1 (2%)
Pituitary Gland (50) (32) (48)
Pars Distalis, Adenoma 29 (58%) 24 (75%) 22 (46%)
Pars Distalis, Adenoma, Multiple 1 (2%) 1 (2%)
Pars Distalis, Carcinoma 2 (4%) 1 (3%) 5 (10%)
Page 2
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:32:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (50) (49)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 8 (16%) 6 (12%)
C-Cell, Adenoma, Multiple 1 (2%)
C-Cell, Carcinoma 3 (6%) 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (38) (2) (40)
Adenoma 5 (13%) 2 (100%) 3 (8%)
Ovary (50) (5) (49)
Uterus (50) (10) (50)
Adenoma 1 (2%)
Polyp Stromal 11 (22%) 6 (60%) 10 (20%)
Sarcoma 1 (10%)
Bilateral, Polyp Stromal 1 (2%) 1 (2%)
Cervix, Sarcoma Stromal 1 (2%)
Endometrium, Deciduoma NOS 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (12) (8)
Bone Marrow (50) (49)
Lymph Node (48) (47) (50)
Carcinoma, Metastatic, Skin 1 (2%)
Spleen (50) (48) (50)
Thymus (39) (47)
Carcinoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (46) (9) (46)
Adenocarcinoma 1 (2%) 1 (11%)
Fibroadenoma 8 (17%) 7 (78%) 3 (7%)
Fibroadenoma, Multiple 1 (2%) 1 (11%) 1 (2%)
Skin (50) (2) (50)
Basosquamous Tumor Benign 1 (2%)
Squamous Cell Papilloma 1 (2%)
Page 3
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:32:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Trichoepithelioma 1 (2%)
Subcutaneous Tissue, Carcinoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (50%) 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Thoracic, Subcutaneous Tissue, Lipoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (50)
Lumbar, Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (48)
Carcinoma, Metastatic, Pituitary Gland 1 (2%) 2 (4%)
Cerebrum, Granular Cell Tumor Benign 1 (2%)
Media, Astrocytoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (1) (50)
Carcinoma, Metastatic, Skin 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (1) (49)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (50) (1) (48)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 11 (22%) 7 (14%) 11 (22%)
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:32:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(50) *(50) *(50)
____________________________________________________________________________________________________________________________________
Page 5
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:32:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 47 36 44
Total Primary Neoplasms 95 58 83
Total Animals with Benign Neoplasms 43 33 37
Total Benign Neoplasms 75 46 61
Total Animals with Malignant Neoplasms 17 12 20
Total Malignant Neoplasms 19 12 22
Total Animals with Metastatic Neoplasms 2 4
Total Metastatic Neoplasm 2 6
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:32:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund 12 16 12
Dead 5 9 6
Survivors
Terminal Sacrifice 33 25 32
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large (47) (1) (47)
Intestine Small (47) (1) (47)
Adenocarcinoma, Metastatic, Kidney 1 (2%)
Jejunum, Sarcoma 1 (2%)
Liver (50) (50) (50)
Adenocarcinoma, Metastatic, Kidney 1 (2%)
Hepatocellular Carcinoma 3 (6%) 1 (2%)
Neoplastic Nodule 3 (6%) 1 (2%)
Neoplastic Nodule, Multiple 1 (2%)
Mesentery (3) (2) (2)
Adenocarcinoma, Metastatic, Kidney 1 (33%)
Pancreas (49) (49)
Adenocarcinoma, Metastatic, Kidney 1 (2%)
Acinus, Adenoma 1 (2%) 1 (2%)
Pharynx (1)
Palate, Squamous Cell Papilloma 1 (100%)
Salivary Glands (50) (50)
Stomach (49) (2) (49)
Forestomach, Squamous Cell Papilloma 1 (2%) 2 (4%)
Tongue (1)
Mucosa, Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (2) (50)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:32:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (3) (50)
Bilateral, Medulla, Pheochromocytoma Complex 1 (2%)
Bilateral, Medulla, Pheochromocytoma Benign 9 (18%) 2 (67%) 6 (12%)
Cortex, Adenoma 1 (2%)
Medulla, Pheochromocytoma Benign 12 (24%) 12 (24%)
Islets, Pancreatic (49) (49)
Adenoma 1 (2%) 1 (2%)
Mixed Tumor Malignant 1 (2%)
Parathyroid Gland (42) (1) (44)
Adenoma 1 (2%) 1 (100%) 1 (2%)
Pituitary Gland (49) (44) (49)
Pars Distalis, Adenoma 6 (12%) 10 (23%) 8 (16%)
Pars Intermedia, Carcinoma 1 (2%)
Thyroid Gland (49) (49) (50)
Bilateral, C-Cell, Adenoma 1 (2%) 1 (2%)
C-Cell, Adenoma 11 (22%) 7 (14%) 5 (10%)
C-Cell, Adenoma, Multiple 1 (2%)
Follicle, Adenoma, Cystic 2 (4%)
Follicle, Adenoma, Cystic, Papillary 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2) (1) (1)
Adenocarcinoma, Metastatic, Kidney 1 (50%)
Chemodectoma Benign 1 (100%)
Chemodectoma Malignant 1 (50%)
Organ Of Zuckerkandl 1 (50%)
Abdominal, Liposarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (1) (50)
Adenocarcinoma, Metastatic, Kidney 1 (2%)
Preputial Gland (43) (3) (47)
Adenoma 2 (5%) 2 (67%) 7 (15%)
Carcinoma 1 (33%)
Prostate (48) (3) (50)
Adenocarcinoma, Metastatic, Kidney 1 (2%)
Testes (50) (38) (50)
Bilateral, Interstitial Cell, Adenoma 35 (70%) 25 (66%) 37 (74%)
Interstitial Cell, Adenoma 13 (26%) 12 (32%) 9 (18%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:32:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (26) (16)
Bone Marrow (49) (50)
Lymph Node (50) (9) (50)
Carcinoma, Metastatic, Skin 1 (2%)
Spleen (50) (14) (50)
Thymus (39) (1) (43)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (25) (4) (22)
Adenocarcinoma 1 (4%) 1 (25%)
Fibroadenoma 1 (4%) 3 (75%)
Skin (49) (12) (50)
Basal Cell Adenoma 1 (8%)
Carcinoma 1 (2%)
Fibrosarcoma 1 (8%)
Keratoacanthoma 1 (2%) 1 (2%)
Squamous Cell Carcinoma 2 (4%)
Squamous Cell Papilloma 2 (4%) 1 (8%) 1 (2%)
Trichoepithelioma 1 (8%) 1 (2%)
Sebaceous Gland, Adenocarcinoma 1 (8%)
Subcutaneous Tissue, Fibroma 4 (8%) 2 (17%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 2 (17%) 2 (4%)
Subcutaneous Tissue, Sarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma NOS 1 (8%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (1) (50)
Carcinoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (3) (50)
Adenocarcinoma, Metastatic, Kidney 1 (2%)
Adenocarcinoma, Metastatic, Mammary Gland 1 (33%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Skin 1 (2%)
Page 9
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:32:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Liposarcoma, Metastatic, Tissue NOS 1 (33%)
Sarcoma, Metastatic 1 (2%)
Mediastinum, Lipoma 1 (2%)
Nose (45) (48) (46)
Turbinate, Respiratory Epithelium,
Adenocarcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (43) (36)
Zymbal's Gland (1) (1)
Carcinoma 1 (100%)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (8) (49)
Mixed Tumor Malignant 1 (13%)
Renal Tubule, Adenocarcinoma 2 (4%)
Urinary Bladder (48) (2) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 31 (62%) 17 (34%) 17 (34%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05052-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 09/07/94
Route: DOSED FEED Time: 20:32:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 5000 PPM 10000
PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 49 48
Total Primary Neoplasms 152 102 119
Total Animals with Benign Neoplasms 48 43 47
Total Benign Neoplasms 106 73 97
Total Animals with Malignant Neoplasms 39 25 21
Total Malignant Neoplasms 45 28 22
Total Animals with Metastatic Neoplasms 3 2
Total Metastatic Neoplasm 12 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1
Total Uncertain Neoplasms 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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