TDMS Study 05052-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus 2,4-DICHLOROPHENOL DATE: 09/07/94
EXPERIMENT: 05052 TEST: 01 TIME: 20:38:43
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-38068 ROUTE: DOSED FEED NTP C#: C55345
PATHOLOGIST: S. ESUTIS R. PERSING CAS: 120-83-2
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus 2,4-DICHLOROPHENOL DATE: 09/07/94
EXPERIMENT: 05052 TEST: 01 TIME: 20:38:43
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-38068 ROUTE: DOSED FEED NTP C#: C55345
PATHOLOGIST: S. ESUTIS R. PERSING CAS: 120-83-2
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus 2,4-DICHLOROPHENOL DATE: 09/07/94
EXPERIMENT: 05052 TEST: 01 TIME: 20:38:43
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-38068 ROUTE: DOSED FEED NTP C#: C55345
PATHOLOGIST: S. ESUTIS R. PERSING CAS: 120-83-2
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF 2,4-DICHLOROPHENOL
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Clitoral/Preputial Gland Adenoma
Carcinoma or Adenoma
Liver Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
Malignant Tumors
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Clitoral/Preputial Gland Adenoma
Carcinoma or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Uterus Polyp Stromal
Sarcoma Stromal or Polyp Stromal
All Organs Benign Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/07/94 EXPERIMENT: 05052 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 2500 PPM 5000 PPM |
| | PPM | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 21/50 (42%) 2/3 (67%) 18/50 (36%) | 5/50 (10%) 3/49 (6%) 3/49 (6%) |
|ADJUSTED (b) | 55.0% 0.0% 43.9% | 13.8% 7.0% 7.0% |
|TERMINAL (d) | 16/33 (48%) 0/0 10/32 (31%) | 4/34 (12%) 3/43 (7%) 2/39 (5%) |
|FIRST INCIDENCE (DAYS) | 663 625 454 | 692 728 (T) 343 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.353N P=0.286N P=0.398N | P=0.232N P=0.250N P=0.306N |
|INCIDENTAL TUMOR | P=0.376N P=0.312 P=0.430N | P=0.253N P=0.315N P=0.326N |
|LOGISTIC REGRESSION | P=0.325N P=0.235 P=0.364N | P=0.289N P=0.310N P=0.357N |
|COCHRAN-ARMITAGE | P=0.305N | P=0.292N |
|FISHER EXACT | P=0.400 P=0.341N | P=0.369N P=0.369N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 22/50 (44%) 2/3 (67%) 18/50 (36%) | 5/50 (10%) 3/49 (6%) 3/49 (6%) |
|ADJUSTED (b) | 57.6% 0.0% 43.9% | 13.8% 7.0% 7.0% |
|TERMINAL (d) | 17/33 (52%) 0/0 10/32 (31%) | 4/34 (12%) 3/43 (7%) 2/39 (5%) |
|FIRST INCIDENCE (DAYS) | 663 625 454 | 692 728 (T) 343 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.285N P=0.286N P=0.329N | P=0.232N P=0.250N P=0.306N |
|INCIDENTAL TUMOR | P=0.304N P=0.312 P=0.353N | P=0.253N P=0.315N P=0.326N |
|LOGISTIC REGRESSION | P=0.257N P=0.243 P=0.292N | P=0.289N P=0.310N P=0.357N |
|COCHRAN-ARMITAGE | P=0.238N | P=0.292N |
|FISHER EXACT | P=0.428 P=0.270N | P=0.369N P=0.369N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05052 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 2500 PPM 5000 PPM |
| | PPM | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/43 (5%) 2/3 (67%) 7/47 (15%) | 5/38 (13%) 2/2 (100%) 3/40 (8%) |
|ADJUSTED (b) | 6.3% 100.0% 21.6% | 16.1% 100.0% 8.3% |
|TERMINAL (d) | 2/32 (6%) 1/1 (100%) 6/31 (19%) | 5/31 (16%) 2/2 (100%) 3/36 (8%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 681 681 | 728 (T) 728 (T) 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.063 P=0.053 P=0.074 | P=0.221N P=0.029 * P=0.275N |
|INCIDENTAL TUMOR | P=0.067 P<0.001 ** P=0.073 | P=0.221N P=0.029 * P=0.275N |
|LOGISTIC REGRESSION | P=0.068 P=0.001 ** P=0.072 | P=0.221N P=0.029 * P=0.275N |
|COCHRAN-ARMITAGE | P=0.094 | P=0.274N |
|FISHER EXACT | P=0.017 * P=0.101 | P=0.027 * P=0.327N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/43 (5%) 3/3 (100%) 7/47 (15%) | 5/38 (13%) 2/2 (100%) 3/40 (8%) |
|ADJUSTED (b) | 6.3% 100.0% 21.6% | 16.1% 100.0% 8.3% |
|TERMINAL (d) | 2/32 (6%) 1/1 (100%) 6/31 (19%) | 5/31 (16%) 2/2 (100%) 3/36 (8%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 625 681 | 728 (T) 728 (T) 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.069 P=0.028 * P=0.074 | P=0.221N P=0.029 * P=0.275N |
|INCIDENTAL TUMOR | P=0.100 P=0.002 ** P=0.073 | P=0.221N P=0.029 * P=0.275N |
|LOGISTIC REGRESSION | P=0.088 P<0.001 ** P=0.072 | P=0.221N P=0.029 * P=0.275N |
|COCHRAN-ARMITAGE | P=0.105 | P=0.274N |
|FISHER EXACT | P<0.001 ** P=0.101 | P=0.027 * P=0.327N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05052 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 2500 PPM 5000 PPM |
| | PPM | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/8 (0%) 0/49 (0%) | 0/50 (0%) 0/1 (0%) 0/49 (0%) |
|ADJUSTED (b) | 5.7% 0.0% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/33 (3%) 0/2 (0%) 0/32 (0%) | 0/34 (0%) 0/1 (0%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | 680 --- --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.125N P=0.485N P=0.243N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.145N P=0.614N P=0.263N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.138N P=0.681N P=0.245N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.136N | (e) |
|FISHER EXACT | P=0.741N P=0.253N | (e) (e) |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/8 (0%) 0/49 (0%) | 1/50 (2%) 0/1 (0%) 0/49 (0%) |
|ADJUSTED (b) | 5.7% 0.0% 0.0% | 2.9% 0.0% 0.0% |
|TERMINAL (d) | 1/33 (3%) 0/2 (0%) 0/32 (0%) | 1/34 (3%) 0/1 (0%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | 680 --- --- | 728 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.125N P=0.485N P=0.243N | P=0.279N P=0.998N P=0.468N |
|INCIDENTAL TUMOR | P=0.145N P=0.614N P=0.263N | P=0.279N P=0.998N P=0.468N |
|LOGISTIC REGRESSION | P=0.138N P=0.681N P=0.245N | P=0.279N P=0.998N P=0.468N |
|COCHRAN-ARMITAGE | P=0.136N | P=0.310N |
|FISHER EXACT | P=0.741N P=0.253N | P=0.980N P=0.505N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05052 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 2500 PPM 5000 PPM |
| | PPM | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 1/23 (4%) 0/50 (0%) |
|ADJUSTED (b) | 12.1% 0.0% 3.1% | 0.0% 5.0% 0.0% |
|TERMINAL (d) | 4/33 (12%) 0/25 (0%) 1/32 (3%) | 0/34 (0%) 1/20 (5%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | 727 (T) --- 727 (T) | --- 728 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.094N P=0.102N P=0.187N | P=0.689N P=0.394 (e) |
|INCIDENTAL TUMOR | P=0.094N P=0.102N P=0.187N | P=0.689N P=0.394 (e) |
|LOGISTIC REGRESSION | P=0.094N P=0.102N P=0.187N | P=0.689N P=0.393 (e) |
|COCHRAN-ARMITAGE | P=0.082N | P=0.711 |
|FISHER EXACT | P=0.059N P=0.181N | P=0.315 (e) |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 0/23 (0%) 0/50 (0%) |
|ADJUSTED (b) | 9.1% 4.0% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/33 (9%) 1/25 (4%) 0/32 (0%) | 0/34 (0%) 0/20 (0%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 727 (T) --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.071N P=0.408N P=0.126N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.071N P=0.408N P=0.126N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.071N P=0.408N P=0.126N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.060N | (e) |
|FISHER EXACT | P=0.309N P=0.121N | (e) (e) |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05052 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 2500 PPM 5000 PPM |
| | PPM | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 1/50 (2%) 1/50 (2%) | 0/50 (0%) 1/23 (4%) 0/50 (0%) |
|ADJUSTED (b) | 15.2% 4.0% 3.1% | 0.0% 5.0% 0.0% |
|TERMINAL (d) | 5/33 (15%) 1/25 (4%) 1/32 (3%) | 0/34 (0%) 1/20 (5%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 727 (T) 727 (T) | --- 728 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.057N P=0.174N P=0.108N | P=0.689N P=0.394 (e) |
|INCIDENTAL TUMOR | P=0.057N P=0.174N P=0.108N | P=0.689N P=0.394 (e) |
|LOGISTIC REGRESSION | P=0.057N P=0.174N P=0.108N | P=0.689N P=0.393 (e) |
|COCHRAN-ARMITAGE | P=0.049N* | P=0.711 |
|FISHER EXACT | P=0.102N P=0.102N | P=0.315 (e) |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 1/50 (2%) 1/50 (2%) | 0/50 (0%) 1/23 (4%) 0/50 (0%) |
|ADJUSTED (b) | 15.2% 4.0% 3.1% | 0.0% 5.0% 0.0% |
|TERMINAL (d) | 5/33 (15%) 1/25 (4%) 1/32 (3%) | 0/34 (0%) 1/20 (5%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 727 (T) 727 (T) | --- 728 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.057N P=0.174N P=0.108N | P=0.689N P=0.394 (e) |
|INCIDENTAL TUMOR | P=0.057N P=0.174N P=0.108N | P=0.689N P=0.394 (e) |
|LOGISTIC REGRESSION | P=0.057N P=0.174N P=0.108N | P=0.689N P=0.393 (e) |
|COCHRAN-ARMITAGE | P=0.049N* | P=0.711 |
|FISHER EXACT | P=0.102N P=0.102N | P=0.315 (e) |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05052 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 2500 PPM 5000 PPM |
| | PPM | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 0/50 (0%) | 9/50 (18%) 8/50 (16%) 4/50 (8%) |
|ADJUSTED (b) | 3.0% 9.0% 0.0% | 20.7% 18.6% 9.5% |
|TERMINAL (d) | 1/33 (3%) 1/25 (4%) 0/32 (0%) | 3/34 (9%) 8/43 (19%) 3/40 (8%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 636 --- | 610 728 (T) 548 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.397N P=0.240 P=0.506N | P=0.072N P=0.363N P=0.108N |
|INCIDENTAL TUMOR | P=0.367N P=0.335 P=0.506N | P=0.174N P=0.592 P=0.270N |
|LOGISTIC REGRESSION | P=0.381N P=0.294 P=0.506N | P=0.098N P=0.503 P=0.114N |
|COCHRAN-ARMITAGE | P=0.378N | P=0.097N |
|FISHER EXACT | P=0.309 P=0.500N | P=0.500N P=0.117N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 4/50 (8%) 0/50 (0%) | 9/50 (18%) 9/50 (18%) 4/50 (8%) |
|ADJUSTED (b) | 6.1% 11.9% 0.0% | 20.7% 20.9% 9.5% |
|TERMINAL (d) | 2/33 (6%) 1/25 (4%) 0/32 (0%) | 3/34 (9%) 9/43 (21%) 3/40 (8%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 636 --- | 610 728 (T) 548 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.244N P=0.254 P=0.245N | P=0.074N P=0.451N P=0.108N |
|INCIDENTAL TUMOR | P=0.226N P=0.342 P=0.245N | P=0.175N P=0.496 P=0.270N |
|LOGISTIC REGRESSION | P=0.228N P=0.311 P=0.245N | P=0.103N P=0.399 P=0.114N |
|COCHRAN-ARMITAGE | P=0.222N | P=0.102N |
|FISHER EXACT | P=0.339 P=0.247N | P=0.602N P=0.117N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05052 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 2500 PPM 5000 PPM |
| | PPM | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/49 (12%) 10/44 (23%) 8/49 (16%) | 30/50 (60%) 24/32 (75%) 23/48 (48%) |
|ADJUSTED (b) | 16.8% 35.6% 21.6% | 67.8% 82.5% 53.4% |
|TERMINAL (d) | 4/32 (13%) 6/22 (27%) 5/32 (16%) | 20/34 (59%) 23/28 (82%) 20/40 (50%) |
|FIRST INCIDENCE (DAYS) | 665 414 454 | 580 647 548 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.342 P=0.081 P=0.383 | P=0.024N* P=0.402N P=0.049N* |
|INCIDENTAL TUMOR | P=0.284 P=0.090 P=0.326 | P=0.164N P=0.195 P=0.257N |
|LOGISTIC REGRESSION | P=0.341 P=0.133 P=0.386 | P=0.123N P=0.190 P=0.150N |
|COCHRAN-ARMITAGE | P=0.343 | P=0.137N |
|FISHER EXACT | P=0.144 P=0.387 | P=0.123 P=0.159N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/44 (0%) 0/49 (0%) | 2/50 (4%) 1/32 (3%) 5/48 (10%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 5.9% 2.3% 12.5% |
|TERMINAL (d) | 0/32 (0%) 0/22 (0%) 0/32 (0%) | 2/34 (6%) 0/28 (0%) 5/40 (13%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 728 (T) 722 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.189 P=0.519N P=0.285 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.136 P=0.707N P=0.285 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.169 P=0.600N P=0.285 |
|COCHRAN-ARMITAGE | (e) | P=0.135 |
|FISHER EXACT | (e) (e) | P=0.664N P=0.201 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05052 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 2500 PPM 5000 PPM |
| | PPM | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/49 (12%) 10/44 (23%) 8/49 (16%) | 32/50 (64%) 25/32 (78%) 28/48 (58%) |
|ADJUSTED (b) | 16.8% 35.6% 21.6% | 72.4% 82.9% 65.0% |
|TERMINAL (d) | 4/32 (13%) 6/22 (27%) 5/32 (16%) | 22/34 (65%) 23/28 (82%) 25/40 (63%) |
|FIRST INCIDENCE (DAYS) | 665 414 454 | 580 647 548 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.342 P=0.081 P=0.383 | P=0.065N P=0.332N P=0.106N |
|INCIDENTAL TUMOR | P=0.284 P=0.090 P=0.326 | P=0.369N P=0.196 P=0.445N |
|LOGISTIC REGRESSION | P=0.341 P=0.133 P=0.386 | P=0.299N P=0.215 P=0.342N |
|COCHRAN-ARMITAGE | P=0.343 | P=0.321N |
|FISHER EXACT | P=0.144 P=0.387 | P=0.133 P=0.356N |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 5.3% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/33 (0%) 0/25 (0%) 0/32 (0%) | 0/34 (0%) 0/43 (0%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 631 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.097 (e) P=0.232 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.089 (e) P=0.272 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.096 (e) P=0.246 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.095 | (e) |
|FISHER EXACT | (e) P=0.247 | (e) (e) |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05052 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 2500 PPM 5000 PPM |
| | PPM | |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 3/50 (6%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.3% 4.0% 8.2% | 2.9% 0.0% 0.0% |
|TERMINAL (d) | 1/33 (3%) 1/25 (4%) 1/32 (3%) | 1/34 (3%) 0/43 (0%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | 663 727 (T) 631 | 728 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.388 P=0.579N P=0.481 | P=0.244N P=0.453N P=0.468N |
|INCIDENTAL TUMOR | P=0.394 P=0.564N P=0.507 | P=0.244N P=0.453N P=0.468N |
|LOGISTIC REGRESSION | P=0.394 P=0.535N P=0.500 | P=0.244N P=0.453N P=0.468N |
|COCHRAN-ARMITAGE | P=0.399 | P=0.269N |
|FISHER EXACT | P=0.500N P=0.500 | P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 1/50 (2%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.3% 4.0% 3.1% | 2.9% 0.0% 0.0% |
|TERMINAL (d) | 1/33 (3%) 1/25 (4%) 1/32 (3%) | 1/34 (3%) 0/43 (0%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | 663 727 (T) 727 (T) | 728 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.396N P=0.579N P=0.516N | P=0.244N P=0.453N P=0.468N |
|INCIDENTAL TUMOR | P=0.403N P=0.564N P=0.528N | P=0.244N P=0.453N P=0.468N |
|LOGISTIC REGRESSION | P=0.389N P=0.535N P=0.507N | P=0.244N P=0.453N P=0.468N |
|COCHRAN-ARMITAGE | P=0.378N | P=0.269N |
|FISHER EXACT | P=0.500N P=0.500N | P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05052 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 2500 PPM 5000 PPM |
| | PPM | |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Basal Cell Carcinoma, or Basal Cell Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 8.0% 2.1% | 0.0% 0.0% 2.5% |
|TERMINAL (d) | 0/33 (0%) 2/25 (8%) 0/32 (0%) | 0/34 (0%) 0/43 (0%) 1/40 (3%) |
|FIRST INCIDENCE (DAYS) | --- 727 (T) 519 | --- --- 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.360 P=0.179 P=0.500 | P=0.286 (e) P=0.532 |
|INCIDENTAL TUMOR | P=0.351 P=0.179 P=0.500 | P=0.286 (e) P=0.532 |
|LOGISTIC REGRESSION | P=0.372 P=0.179 P=0.610 | P=0.286 (e) P=0.532 |
|COCHRAN-ARMITAGE | P=0.360 | P=0.269 |
|FISHER EXACT | P=0.247 P=0.500 | (e) P=0.500 |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 3/50 (6%) 5/50 (10%) | 1/50 (2%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 7.5% 12.0% 13.1% | 2.9% 0.0% 2.5% |
|TERMINAL (d) | 1/33 (3%) 3/25 (12%) 2/32 (6%) | 1/34 (3%) 0/43 (0%) 1/40 (3%) |
|FIRST INCIDENCE (DAYS) | 656 727 (T) 519 | 728 (T) --- 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.275 P=0.550 P=0.340 | P=0.639N P=0.453N P=0.725N |
|INCIDENTAL TUMOR | P=0.268 P=0.575 P=0.348 | P=0.639N P=0.453N P=0.725N |
|LOGISTIC REGRESSION | P=0.282 P=0.620 P=0.377 | P=0.639N P=0.453N P=0.725N |
|COCHRAN-ARMITAGE | P=0.283 | P=0.669N |
|FISHER EXACT | P=0.661N P=0.357 | P=0.500N P=0.753N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05052 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 2500 PPM 5000 PPM |
| | PPM | |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 11.5% 4.8% 2.5% | 0.0% 2.3% 4.0% |
|TERMINAL (d) | 3/33 (9%) 0/25 (0%) 0/32 (0%) | 0/34 (0%) 1/43 (2%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | 674 414 659 | --- 728 (T) 343 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.133N P=0.417N P=0.192N | P=0.151 P=0.547 P=0.240 |
|INCIDENTAL TUMOR | P=0.137N P=0.334N P=0.209N | P=0.280 P=0.547 P=0.401 |
|LOGISTIC REGRESSION | P=0.104N P=0.287N P=0.184N | P=0.157 P=0.547 P=0.252 |
|COCHRAN-ARMITAGE | P=0.118N | P=0.142 |
|FISHER EXACT | P=0.339N P=0.181N | P=0.500 P=0.247 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 2/50 (4%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 6.6% 5.5% | 2.0% 0.0% 0.0% |
|TERMINAL (d) | 0/33 (0%) 1/25 (4%) 0/32 (0%) | 0/34 (0%) 0/43 (0%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | --- 665 674 | 289 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.178 P=0.199 P=0.237 | P=0.271N P=0.504N P=0.500N |
|INCIDENTAL TUMOR | P=0.145 P=0.209 P=0.195 | P=0.183N P=0.500N P=0.362N |
|LOGISTIC REGRESSION | P=0.175 P=0.223 P=0.239 | P=0.215N P=0.362N P=0.362N |
|COCHRAN-ARMITAGE | P=0.176 | P=0.269N |
|FISHER EXACT | P=0.247 P=0.247 | P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05052 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 2500 PPM 5000 PPM |
| | PPM | |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 4/50 (8%) 3/50 (6%) | 1/50 (2%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 13.3% 11.1% 7.9% | 2.0% 2.3% 4.0% |
|TERMINAL (d) | 3/33 (9%) 1/25 (4%) 0/32 (0%) | 0/34 (0%) 1/43 (2%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | 548 414 659 | 289 728 (T) 343 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.313N P=0.596N P=0.374N | P=0.391 P=0.737N P=0.500 |
|INCIDENTAL TUMOR | P=0.321N P=0.454N P=0.377N | P=0.597 P=0.735N P=0.773 |
|LOGISTIC REGRESSION | P=0.265N P=0.426N P=0.345N | P=0.447 P=0.765N P=0.757 |
|COCHRAN-ARMITAGE | P=0.290N | P=0.378 |
|FISHER EXACT | P=0.500N P=0.357N | P=0.753N P=0.500 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 2/50 (4%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.1% 6.6% 5.5% | 2.0% 0.0% 0.0% |
|TERMINAL (d) | 0/33 (0%) 1/25 (4%) 0/32 (0%) | 0/34 (0%) 0/43 (0%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | 548 665 674 | 289 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.385 P=0.449 P=0.494 | P=0.271N P=0.504N P=0.500N |
|INCIDENTAL TUMOR | P=0.373 P=0.575 P=0.516 | P=0.183N P=0.500N P=0.362N |
|LOGISTIC REGRESSION | P=0.403 P=0.551 P=0.540 | P=0.215N P=0.362N P=0.362N |
|COCHRAN-ARMITAGE | P=0.390 | P=0.269N |
|FISHER EXACT | P=0.500 P=0.500 | P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05052 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 2500 PPM 5000 PPM |
| | PPM | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 3.0% 0.0% 5.1% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/33 (3%) 0/25 (0%) 1/32 (3%) | 0/34 (0%) 0/43 (0%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | 727 (T) --- 454 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.359 P=0.555N P=0.493 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.351 P=0.555N P=0.493 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.385 P=0.555N P=0.542 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.360 | (e) |
|FISHER EXACT | P=0.500N P=0.500 | (e) (e) |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 48/50 (96%) 37/38 (97%) 46/50 (92%) | |
|ADJUSTED (b) | 100.0% 100.0% 97.9% | |
|TERMINAL (d) | 33/33 (100%) 24/24 (100%) 31/32 (97%) | |
|FIRST INCIDENCE (DAYS) | 548 477 454 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.496N P=0.572N P=0.531N | |
|INCIDENTAL TUMOR | P=0.406N P=0.723 P=0.528N | |
|LOGISTIC REGRESSION | P=0.331N P=0.777N P=0.427N | |
|COCHRAN-ARMITAGE | P=0.247N | |
|FISHER EXACT | P=0.603 P=0.339N | |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05052 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 2500 PPM 5000 PPM |
| | PPM | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/49 (22%) 9/49 (18%) 6/50 (12%) | 9/50 (18%) 0/0 (0%) 7/49 (14%) |
|ADJUSTED (b) | 32.2% 30.3% 17.3% | 24.7% 0.0% 16.7% |
|TERMINAL (d) | 10/33 (30%) 6/24 (25%) 5/32 (16%) | 7/34 (21%) 0/0 6/40 (15%) |
|FIRST INCIDENCE (DAYS) | 680 469 454 | 695 --- 343 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.139N P=0.529 P=0.154N | P=0.232N P=0.208N P=0.282N |
|INCIDENTAL TUMOR | P=0.127N P=0.557N P=0.157N | P=0.308N (e) P=0.358N |
|LOGISTIC REGRESSION | P=0.117N P=0.497N P=0.144N | P=0.308N (e) P=0.358N |
|COCHRAN-ARMITAGE | P=0.108N | P=0.357N |
|FISHER EXACT | P=0.401N P=0.133N | P=1.000N P=0.410N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/49 (0%) 0/50 (0%) | 3/50 (6%) 0/0 (0%) 3/49 (6%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 8.1% 0.0% 7.2% |
|TERMINAL (d) | 0/33 (0%) 0/24 (0%) 0/32 (0%) | 2/34 (6%) 0/0 2/40 (5%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 692 --- 671 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.534N P=0.495N P=0.614N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.456 (e) P=0.544 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.456 (e) P=0.544 |
|COCHRAN-ARMITAGE | (e) | P=0.573 |
|FISHER EXACT | (e) (e) | P=1.000N P=0.651 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05052 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 2500 PPM 5000 PPM |
| | PPM | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/49 (22%) 9/49 (18%) 6/50 (12%) | 12/50 (24%) 0/0 (0%) 10/49 (20%) |
|ADJUSTED (b) | 32.2% 30.3% 17.3% | 31.9% 0.0% 23.4% |
|TERMINAL (d) | 10/33 (30%) 6/24 (25%) 5/32 (16%) | 9/34 (26%) 0/0 8/40 (20%) |
|FIRST INCIDENCE (DAYS) | 680 469 454 | 692 --- 343 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.139N P=0.529 P=0.154N | P=0.236N P=0.106N P=0.284N |
|INCIDENTAL TUMOR | P=0.127N P=0.557N P=0.157N | P=0.396N (e) P=0.445N |
|LOGISTIC REGRESSION | P=0.117N P=0.497N P=0.144N | P=0.396N (e) P=0.445N |
|COCHRAN-ARMITAGE | P=0.108N | P=0.379N |
|FISHER EXACT | P=0.401N P=0.133N | P=1.000N P=0.426N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 3/49 (6%) 0/50 (0%) | 0/50 (0%) 0/0 (0%) 0/49 (0%) |
|ADJUSTED (b) | 0.0% 11.4% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/33 (0%) 2/24 (8%) 0/32 (0%) | 0/34 (0%) 0/0 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | --- 700 --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.625 P=0.082 (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.622 P=0.092 (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.630 P=0.088 (e) | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.634N | (e) |
|FISHER EXACT | P=0.121 (e) | (e) (e) |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05052 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 2500 PPM 5000 PPM |
| | PPM | |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 12/50 (24%) 6/50 (12%) 11/50 (22%) |
|ADJUSTED (b) | | 35.3% 13.2% 24.9% |
|TERMINAL (d) | | 12/34 (35%) 4/43 (9%) 8/40 (20%) |
|FIRST INCIDENCE (DAYS) | | 728 (T) 584 343 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.333N P=0.036N* P=0.352N |
|INCIDENTAL TUMOR | | P=0.335N P=0.051N P=0.304N |
|LOGISTIC REGRESSION | | P=0.445N P=0.080N P=0.498N |
|COCHRAN-ARMITAGE | | P=0.450N |
|FISHER EXACT | | P=0.096N P=0.500N |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 13/50 (26%) 6/50 (12%) 11/50 (22%) |
|ADJUSTED (b) | | 36.6% 13.2% 24.9% |
|TERMINAL (d) | | 12/34 (35%) 4/43 (9%) 8/40 (20%) |
|FIRST INCIDENCE (DAYS) | | 429 584 343 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.252N P=0.023N* P=0.275N |
|INCIDENTAL TUMOR | | P=0.223N P=0.051N P=0.203N |
|LOGISTIC REGRESSION | | P=0.342N P=0.063N P=0.395N |
|COCHRAN-ARMITAGE | | P=0.354N |
|FISHER EXACT | | P=0.062N P=0.408N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05052 TEST: 01 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 2500 PPM 5000 PPM |
| | PPM | |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 31/50 (62%) 17/50 (34%) 17/50 (34%) | 11/50 (22%) 7/50 (14%) 11/50 (22%) |
|ADJUSTED (b) | 68.2% 46.0% 41.2% | 26.8% 15.4% 24.3% |
|TERMINAL (d) | 19/33 (58%) 7/25 (28%) 9/32 (28%) | 5/34 (15%) 5/43 (12%) 7/40 (18%) |
|FIRST INCIDENCE (DAYS) | 419 469 454 | 636 584 343 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.017N* P=0.089N P=0.021N* | P=0.460N P=0.134N P=0.493N |
|INCIDENTAL TUMOR | P=0.005N** P=0.005N** P=0.006N** | P=0.392 P=0.428N P=0.459 |
|LOGISTIC REGRESSION | P=0.003N** P=0.005N** P=0.004N** | P=0.531N P=0.378N P=0.572N |
|COCHRAN-ARMITAGE | P=0.003N** | P=0.550N |
|FISHER EXACT | P=0.004N** P=0.004N** | P=0.218N P=0.595N |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 48/50 (96%) 43/50 (86%) 47/50 (94%) | 43/50 (86%) 33/50 (66%) 37/50 (74%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 93.4% 71.7% 78.6% |
|TERMINAL (d) | 33/33 (100%) 25/25 (100%) 32/32 (100%) | 31/34 (91%) 30/43 (70%) 30/40 (75%) |
|FIRST INCIDENCE (DAYS) | 548 414 454 | 580 584 343 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.502 P=0.240 P=0.541 | P=0.025N* P<0.001N** P=0.033N* |
|INCIDENTAL TUMOR | P=0.566 P=0.284N P=0.679 | P=0.134N P=0.008N** P=0.137N |
|LOGISTIC REGRESSION | P=0.529N P=0.207N P=0.648N | P=0.112N P=0.006N** P=0.116N |
|COCHRAN-ARMITAGE | P=0.427N | P=0.101N |
|FISHER EXACT | P=0.080N P=0.500N | P=0.017N* P=0.105N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05052 TEST: 01 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 5000 PPM 10000 | 0 PPM 2500 PPM 5000 PPM |
| | PPM | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 39/50 (78%) 25/50 (50%) 21/50 (42%) | 17/50 (34%) 12/50 (24%) 20/50 (40%) |
|ADJUSTED (b) | 81.1% 60.5% 48.1% | 38.3% 25.4% 43.1% |
|TERMINAL (d) | 24/33 (73%) 10/25 (40%) 10/32 (31%) | 8/34 (24%) 8/43 (19%) 14/40 (35%) |
|FIRST INCIDENCE (DAYS) | 419 426 454 | 289 562 343 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.006N** P=0.160N P=0.007N** | P=0.429 P=0.105N P=0.489 |
|INCIDENTAL TUMOR | P<0.001N** P=0.002N** P<0.001N** | P=0.188 P=0.450N P=0.274 |
|LOGISTIC REGRESSION | P<0.001N** P=0.002N** P<0.001N** | P=0.323 P=0.215N P=0.370 |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.297 |
|FISHER EXACT | P=0.003N** P<0.001N** | P=0.189N P=0.339 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 50/50 (100%) 49/50 (98%) 48/50 (96%) | 47/50 (94%) 36/50 (72%) 44/50 (88%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 95.9% 75.0% 88.0% |
|TERMINAL (d) | 33/33 (100%) 25/25 (100%) 32/32 (100%) | 32/34 (94%) 31/43 (72%) 34/40 (85%) |
|FIRST INCIDENCE (DAYS) | 419 414 454 | 289 562 343 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.500N P=0.096 P=0.532N | P=0.085N P<0.001N** P=0.094N |
|INCIDENTAL TUMOR | P=0.349N P=0.682N P=0.602N | P=0.343N P=0.011N* P=0.301N |
|LOGISTIC REGRESSION | P=0.228N P=0.626N P=0.401N | P=0.247N P=0.003N** P=0.238N |
|COCHRAN-ARMITAGE | P=0.142N | P=0.244N |
|FISHER EXACT | P=0.500N P=0.247N | P=0.003N** P=0.243N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05052 TEST: 01 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 2,4-DICHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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