TDMS Study 05052-01 Pathology Tables
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
Facility: Battelle Columbus Laboratory
Chemical CAS #: 120-83-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 2| 2| 2| 2| 0| 2| 1| 2| 5| 2| 0| 2|
| 9| 9| 9| 9| 9| 9| 9| 0| 9| 9| 9| 9| 5| 9| 9| 9| 9| 8| 9| 3| 9| 9| 9| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Rectum, Parasite Metazoan | 2 |
Rectum, Parasite Metazoan, Multifocal| 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + M M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X|
Basophilic Focus, Single | X |
Clear Cell Focus, Single | X |
Hemorrhage, Acute, Multifocal | 3 |
Inflammation, Granulomatous, | |
Multifocal | 2 2 2 2 2 2 2 2 2 2 2 4|
Bile Duct, Hyperplasia, Multifocal | 2 2 2 3 3 |
Hepatocyte, Degeneration, Cystic, | |
Focal | 2 |
Hepatocyte, Necrosis, Acute, | |
Multifocal | 2 3 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Multifocal | 1 3 2 2 3 4 |
Periportal, Hematopoietic Cell | |
Proliferation, Multifocal | 2 3|
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic, Multifocal | |
Inflammation, Focal, Granulomatous | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 1 2 3 |
Acinus, Atrophy, Multifocal | 2 2 2 2 1 3 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glandular, Ulcer, Acute, Multifocal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Degeneration, Chronic, | |
Multifocal | 2 1 2 2 1 3 1 1 2 3 2 2 2 2 2 1 2 1 2 3|
Myocardium, Inflammation, Acute, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 2| 2| 2| 2| 0| 2| 1| 2| 5| 2| 0| 2|
| 9| 9| 9| 9| 9| 9| 9| 0| 9| 9| 9| 9| 5| 9| 9| 9| 9| 8| 9| 3| 9| 9| 9| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Cortex, Congestion, | |
Multifocal | 3 |
Bilateral, Cortex, Congestion, | |
Multifocal, Subacute | 3 |
Bilateral, Cortex, Hyperplasia, Focal| 2 |
Bilateral, Cortex, Hyperplasia, | |
Multifocal | 2 |
Bilateral, Medulla, Hyperplasia, | |
Multifocal | 3|
Cortex, Cyst | |
Cortex, Cytoplasmic Alteration, Focal| 2 2 |
Cortex, Degeneration, Cystic, Focal | 2 |
Cortex, Degeneration, Fatty, Focal | 2 2 3 3 2 2 3 |
Cortex, Degeneration, Fatty, | |
Multifocal | |
Cortex, Hyperplasia, Focal | 2 2 2 |
Cortex, Hyperplasia, Multifocal | 2 2 |
Cortex, Hypertrophy, Focal | 3 |
Cortex, Karyomegaly, Focal | |
Cortex, Necrosis, Multifocal | 2 |
Medulla, Hyperplasia, Focal | 2 |
Medulla, Hyperplasia, Multifocal | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M M M + + + + + + + + M + + + + + M +|
Hyperplasia, Multifocal | 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Cyst, Multiple | X X X X X X|
Pars Distalis, Cyst, Single | X |
Pars Distalis, Hemorrhage, Focal | 3 |
Pars Distalis, Hemorrhage, Multifocal| 3 |
Pars Distalis, Hyperplasia, Focal | 2 3 |
Pars Distalis, Hyperplasia, | |
Multifocal | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Multifocal | 2 2 2 2 2 1 2 3 2 2 2 2 2 2 2 2 2 |
Follicle, Cyst, Single | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 2| 2| 2| 2| 0| 2| 1| 2| 5| 2| 0| 2|
| 9| 9| 9| 9| 9| 9| 9| 0| 9| 9| 9| 9| 5| 9| 9| 9| 9| 8| 9| 3| 9| 9| 9| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + + + + M + + + + + + M + + +|
Cyst, Multiple | X X |
Inflammation, Chronic Active, Focal | 2 |
Inflammation, Chronic Active, | |
Multifocal | 2 |
Inflammation, Multifocal, Subacute | 2 |
Necrosis, Acute, Focal | |
Necrosis, Chronic Active, Focal | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Periovarian Tissue, Cyst | |
Bilateral, Follicle, Cyst | |
Follicle, Cyst, Multiple | X |
Follicle, Cyst, Single | X X|
Germinal Epithelium, Mineralization, | |
Multifocal | |
Left, Follicle, Cyst | |
Periovarian Tissue, Cyst | X |
Periovarian Tissue, Right, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Inflammation, Chronic Active, | |
Multifocal | |
Cervix, Diverticulum | X |
Cervix, Inflammation, Multifocal, | |
Suppurative | 3 |
Endometrium, Hyperplasia, Cystic, | |
Glandular, Multifocal | 2 3 2 2 2 2 3 2 2 2 2|
Lumen, Ectasia, Multifocal | 4 |
Lumen, Right, Ectasia, Focal | |
Lumen, Right, Ectasia, Multifocal | |
Serosa, Inflammation, Chronic, Focal | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Multifocal, Neutrophil | |
Hyperplasia, Multifocal, Reticulum | |
Cell | 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Mandibular, Hemorrhage, Multifocal | 3 2 3 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 2| 2| 2| 2| 0| 2| 1| 2| 5| 2| 0| 2|
| 9| 9| 9| 9| 9| 9| 9| 0| 9| 9| 9| 9| 5| 9| 9| 9| 9| 8| 9| 3| 9| 9| 9| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mandibular, Hyperplasia, Lymphoid, | |
Multifocal | 2 3 3 |
Mandibular, Hyperplasia, Multifocal, | |
Plasma Cell | 3 3 3 3 |
Mandibular, Inflammation, | |
Granulomatous, Multifocal | 2 2|
Mediastinal, Depletion Lymphoid, | |
Multifocal | |
Mediastinal, Hemorrhage, Multifocal | 3 3 3 3 |
Mediastinal, Inflammation, | |
Granulomatous, Multifocal | 3 3 2 2|
__________________________________________________________________________|
Lymph Node, Mandibular | |
__________________________________________________________________________|
Lymph Node, Mesenteric | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Follicle, Depletion | |
Lymphoid, Multifocal | |
Lymphoid Follicle, Inflammation, | |
Granulomatous, Multifocal | 2 |
Red Pulp, Congestion, Focal | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Multifocal | 2 3 2 2 2 3 2 2 2 3|
Red Pulp, Necrosis, Acute, Focal | 3 |
Red Pulp, Pigmentation, Hemosiderin, | |
Multifocal | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M M + + + M + + + + + M + +|
Depletion Lymphoid, Multifocal | 3 2 3 2 2 2 3 2 3 2 3 2 3 2 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Hyperplasia, Cystic, | |
Multifocal | 3 3 3 3 3 3 3 3 3 3 3 2 2 2|
Acinus, Hyperplasia, Cystic, Multiple| 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Subcutaneous Tissue, | |
Inflammation, Chronic Active, | |
Multifocal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + M + + + + + + + + + + + + + + + + + + +|
Femur, Osteopetrosis, Multifocal | 3 2 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Hemorrhage, Acute, Focal | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 2| 2| 2| 2| 0| 2| 1| 2| 5| 2| 0| 2|
| 9| 9| 9| 9| 9| 9| 9| 0| 9| 9| 9| 9| 5| 9| 9| 9| 9| 8| 9| 3| 9| 9| 9| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Cerebrum, Compression, Focal | 3 4 3 |
Medulla, Hemorrhage, Multifocal | 2 |
Ventricle, Hydrocephalus, Multifocal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Acute, Multifocal | |
Hemorrhage, Acute, Multifocal | 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 3 |
Interstitium, Inflammation, Acute, | |
Focal | |
__________________________________________________________________________|
Nose | + + + + + + + M + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Focal, Subacute | 2 2 2|
Nasolacrimal Duct, Inflammation, | |
Multifocal, Subacute | 2 2 2 3 2 2 3 3 |
Respiratory Epithelium, Degeneration,| |
Multifocal | 3 2 2 2 2 2 2 3 2|
Submucosa, Respiratory Epithelium, | |
Congestion, Acute, Multifocal | 3 |
Submucosa, Respiratory Epithelium, | |
Inflammation, Multifocal, | |
Subacute | 2 2 2 2 1 2 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Hemorrhage, Acute, Multifocal | 3 |
Lens, Cataract, Multifocal | 2 |
Retina, Atrophy, Multifocal | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Multifocal, Subacute | 2 2 2 2 2 2 2 2 2 2 3|
Bilateral, Inflammation, Multifocal, | |
Subacute | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Nephropathy, Chronic, | |
Multifocal | 2 1 1 2 3 2 1 2 3 3 3 3 4 4 1 2 3 3 1 2 2 1 1 3|
Cortex, Casts, Single | |
Cortex, Inflammation, Chronic, Focal | 3 |
Medulla, Left, Cyst, Multiple | X |
Renal Tubule, Degeneration, Acute, | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 2| 2| 2| 2| 0| 2| 1| 2| 5| 2| 0| 2|
| 9| 9| 9| 9| 9| 9| 9| 0| 9| 9| 9| 9| 5| 9| 9| 9| 9| 8| 9| 3| 9| 9| 9| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Multifocal | |
Renal Tubule, Vacuolization | |
Cytoplasmic, Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 2| 6| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 2| 2| 3| 2| 2| 2| 6| 2| 2| 2| 9| 9| 2| 2| 2| 8| 2| 8| 9| 2| 2| 2| 2| 9| 2| |
| 9| 9| 6| 9| 9| 9| 0| 9| 9| 9| 3| 2| 9| 9| 9| 0| 9| 9| 3| 9| 9| 9| 9| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + A + + + + + + + A +| 48 |
Rectum, Parasite Metazoan | 2 | 2 2.0|
Rectum, Parasite Metazoan, Multifocal| | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + A + + + + + + + A +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | | 1 2.0|
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X X | 33 |
Basophilic Focus, Single | X | 2 |
Clear Cell Focus, Single | X | 2 |
Hemorrhage, Acute, Multifocal | | 1 3.0|
Inflammation, Granulomatous, | | |
Multifocal | 2 2 3 2 2 2 2 2 3 3 3 3 2 4| 26 2.3|
Bile Duct, Hyperplasia, Multifocal | 3 2 2 | 8 2.4|
Hepatocyte, Degeneration, Cystic, | | |
Focal | | 1 2.0|
Hepatocyte, Necrosis, Acute, | | |
Multifocal | 2 | 3 2.3|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Multifocal | 4 3 4| 9 2.9|
Periportal, Hematopoietic Cell | | |
Proliferation, Multifocal | | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Inflammation, Chronic, Multifocal | 2 | 1 2.0|
Inflammation, Focal, Granulomatous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy, Focal | 2 2| 5 2.0|
Acinus, Atrophy, Multifocal | 2 2 2 3 3 3 2 | 15 2.2|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Glandular, Ulcer, Acute, Multifocal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 2| 6| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 2| 2| 3| 2| 2| 2| 6| 2| 2| 2| 9| 9| 2| 2| 2| 8| 2| 8| 9| 2| 2| 2| 2| 9| 2| |
| 9| 9| 6| 9| 9| 9| 0| 9| 9| 9| 3| 2| 9| 9| 9| 0| 9| 9| 3| 9| 9| 9| 9| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myocardium, Degeneration, Chronic, | | |
Multifocal | 1 2 1 2 2 2 2 3 2 2 2 3 2 2 2 2 2 2 3 2| 40 2.0|
Myocardium, Inflammation, Acute, | | |
Multifocal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Cortex, Congestion, | | |
Multifocal | | 1 3.0|
Bilateral, Cortex, Congestion, | | |
Multifocal, Subacute | | 1 3.0|
Bilateral, Cortex, Hyperplasia, Focal| | 1 2.0|
Bilateral, Cortex, Hyperplasia, | | |
Multifocal | | 1 2.0|
Bilateral, Medulla, Hyperplasia, | | |
Multifocal | | 1 3.0|
Cortex, Cyst | X | 1 |
Cortex, Cytoplasmic Alteration, Focal| 3 | 3 2.3|
Cortex, Degeneration, Cystic, Focal | | 1 2.0|
Cortex, Degeneration, Fatty, Focal | 2 2 2 2 2 | 12 2.3|
Cortex, Degeneration, Fatty, | | |
Multifocal | 2 2 | 2 2.0|
Cortex, Hyperplasia, Focal | 2 2 2 2 2 | 8 2.0|
Cortex, Hyperplasia, Multifocal | | 2 2.0|
Cortex, Hypertrophy, Focal | 3 | 2 3.0|
Cortex, Karyomegaly, Focal | 2 2 2 | 3 2.0|
Cortex, Necrosis, Multifocal | | 1 2.0|
Medulla, Hyperplasia, Focal | 2 | 2 2.0|
Medulla, Hyperplasia, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + +| 17 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + +| 34 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M M M M + + + + M M + + + + + + M + + M + +| 36 |
Hyperplasia, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Cyst, Multiple | X X X X X X | 12 |
Pars Distalis, Cyst, Single | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 2| 6| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 2| 2| 3| 2| 2| 2| 6| 2| 2| 2| 9| 9| 2| 2| 2| 8| 2| 8| 9| 2| 2| 2| 2| 9| 2| |
| 9| 9| 6| 9| 9| 9| 0| 9| 9| 9| 3| 2| 9| 9| 9| 0| 9| 9| 3| 9| 9| 9| 9| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Hemorrhage, Focal | | 1 3.0|
Pars Distalis, Hemorrhage, Multifocal| 3 3 3 | 4 3.0|
Pars Distalis, Hyperplasia, Focal | 2 3 3 | 5 2.6|
Pars Distalis, Hyperplasia, | | |
Multifocal | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2| 30 2.0|
Follicle, Cyst, Single | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + M + + + M + + M + + + + M + M + + + M + M +| 38 |
Cyst, Multiple | | 2 |
Inflammation, Chronic Active, Focal | | 1 2.0|
Inflammation, Chronic Active, | | |
Multifocal | | 1 2.0|
Inflammation, Multifocal, Subacute | | 1 2.0|
Necrosis, Acute, Focal | 2 | 1 2.0|
Necrosis, Chronic Active, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Periovarian Tissue, Cyst | X | 1 |
Bilateral, Follicle, Cyst | X | 1 |
Follicle, Cyst, Multiple | | 1 |
Follicle, Cyst, Single | | 2 |
Germinal Epithelium, Mineralization, | | |
Multifocal | 2 | 1 2.0|
Left, Follicle, Cyst | X | 1 |
Periovarian Tissue, Cyst | | 1 |
Periovarian Tissue, Right, Cyst | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 3 | 2 3.5|
Inflammation, Chronic Active, | | |
Multifocal | 3 | 1 3.0|
Cervix, Diverticulum | X | 2 |
Cervix, Inflammation, Multifocal, | | |
Suppurative | | 1 3.0|
Endometrium, Hyperplasia, Cystic, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 2| 6| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 2| 2| 3| 2| 2| 2| 6| 2| 2| 2| 9| 9| 2| 2| 2| 8| 2| 8| 9| 2| 2| 2| 2| 9| 2| |
| 9| 9| 6| 9| 9| 9| 0| 9| 9| 9| 3| 2| 9| 9| 9| 0| 9| 9| 3| 9| 9| 9| 9| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Glandular, Multifocal | 2 2 2 2 2 1 2 2 2 2 2 2 2| 24 2.0|
Lumen, Ectasia, Multifocal | 3 3 | 3 3.3|
Lumen, Right, Ectasia, Focal | 3 | 1 3.0|
Lumen, Right, Ectasia, Multifocal | 3 | 1 3.0|
Serosa, Inflammation, Chronic, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + | 12 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Multifocal, Neutrophil | 3 | 1 3.0|
Hyperplasia, Multifocal, Reticulum | | |
Cell | 3 3 | 5 2.4|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + M + + + + + + + + + M + + + + + + +| 48 |
Hemorrhage | X | 1 |
Mandibular, Hemorrhage, Multifocal | 2 2 2 2 2 2 | 9 2.2|
Mandibular, Hyperplasia, Lymphoid, | | |
Multifocal | 2 2 | 5 2.4|
Mandibular, Hyperplasia, Multifocal, | | |
Plasma Cell | | 4 3.0|
Mandibular, Inflammation, | | |
Granulomatous, Multifocal | 2 2| 4 2.0|
Mediastinal, Depletion Lymphoid, | | |
Multifocal | 2 | 1 2.0|
Mediastinal, Hemorrhage, Multifocal | 2 3 | 6 2.8|
Mediastinal, Inflammation, | | |
Granulomatous, Multifocal | 2 2| 6 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoid Follicle, Depletion | | |
Lymphoid, Multifocal | 2 2 | 2 2.0|
Lymphoid Follicle, Inflammation, | | |
Granulomatous, Multifocal | 3 | 2 2.5|
Red Pulp, Congestion, Focal | 2 | 1 2.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Multifocal | 2 2 3 2 2 2 2 2 2 3 2 2 2 3 2| 25 2.2|
Red Pulp, Necrosis, Acute, Focal | | 1 3.0|
Red Pulp, Pigmentation, Hemosiderin, | | |
Multifocal | 3 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 2| 6| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 2| 2| 3| 2| 2| 2| 6| 2| 2| 2| 9| 9| 2| 2| 2| 8| 2| 8| 9| 2| 2| 2| 2| 9| 2| |
| 9| 9| 6| 9| 9| 9| 0| 9| 9| 9| 3| 2| 9| 9| 9| 0| 9| 9| 3| 9| 9| 9| 9| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + M + M + M M + M + + + + + M M + + + + + + + +| 39 |
Depletion Lymphoid, Multifocal | 2 2 2 2 3 3 2 2 2 3 2 2 2 3 3| 30 2.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + M + + + + + + + + + + + M + M + +| 46 |
Acinus, Hyperplasia, Cystic, | | |
Multifocal | 3 3 2 3 4 3 2 3 3 2 4 2| 26 2.8|
Acinus, Hyperplasia, Cystic, Multiple| | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Subcutaneous Tissue, | | |
Inflammation, Chronic Active, | | |
Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Femur, Osteopetrosis, Multifocal | 2 2 2 | 7 2.4|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cerebellum, Hemorrhage, Acute, Focal | 4 | 1 4.0|
Cerebrum, Compression, Focal | 3 3 3 2 3 3| 9 3.0|
Medulla, Hemorrhage, Multifocal | | 1 2.0|
Ventricle, Hydrocephalus, Multifocal | 3 3 2| 3 2.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion, Acute, Multifocal | 3 3 | 2 3.0|
Hemorrhage, Acute, Multifocal | 2 | 2 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | | 1 3.0|
Interstitium, Inflammation, Acute, | | |
Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | M + + + + + M + + + + + + + + M + M + + + + + + +| 45 |
Nasolacrimal Duct, Inflammation, | | |
Focal, Subacute | 2 2 | 5 2.0|
Nasolacrimal Duct, Inflammation, | | |
Multifocal, Subacute | 2 3 2 3 2 2 2 3 2 3 | 18 2.4|
Respiratory Epithelium, Degeneration,| | |
Multifocal | 2 2 2 2 3 2 3 2 2 2 | 19 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 2| 6| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 2| 2| 3| 2| 2| 2| 6| 2| 2| 2| 9| 9| 2| 2| 2| 8| 2| 8| 9| 2| 2| 2| 2| 9| 2| |
| 9| 9| 6| 9| 9| 9| 0| 9| 9| 9| 3| 2| 9| 9| 9| 0| 9| 9| 3| 9| 9| 9| 9| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Submucosa, Respiratory Epithelium, | | |
Congestion, Acute, Multifocal | | 1 3.0|
Submucosa, Respiratory Epithelium, | | |
Inflammation, Multifocal, | | |
Subacute | 2 2 2 2 2 2 2 2 2 2 2| 21 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
Hemorrhage, Acute, Multifocal | | 1 3.0|
Lens, Cataract, Multifocal | | 1 2.0|
Retina, Atrophy, Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + M + + + + + + M + + + + + + +| 40 |
Inflammation, Multifocal, Subacute | 3 2 2 2 | 15 2.1|
Bilateral, Inflammation, Multifocal, | | |
Subacute | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Nephropathy, Chronic, | | |
Multifocal | 2 2 1 1 2 3 2 2 2 2 1 2 3 2 4 2 1 3 3 2 3 3| 46 2.2|
Cortex, Casts, Single | X | 1 |
Cortex, Inflammation, Chronic, Focal | | 1 3.0|
Medulla, Left, Cyst, Multiple | | 1 |
Renal Tubule, Degeneration, Acute, | | |
Multifocal | 4 3 | 2 3.5|
Renal Tubule, Vacuolization | | |
Cytoplasmic, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2500 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Liver | + + + + + + + + + + |
Angiectasis, Multifocal | 3 |
Basophilic Focus, Multiple | X X X X X X X X X |
Basophilic Focus, Single | |
Clear Cell Focus | X |
Cyst | |
Inflammation, Focal, Granulomatous | |
Inflammation, Granulomatous, | |
Multifocal | 2 2 2 1 2 |
Inflammation, Multifocal, Subacute | 2 |
Bile Duct, Hyperplasia, Multifocal | |
Hepatocyte, Degeneration, Cystic, | |
Focal | 3 2 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 1 1 1 2 2 1 2|
Acinus, Atrophy, Multifocal | 2 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Cortex, Atrophy, Diffuse | 3|
Bilateral, Cortex, Congestion, | |
Multifocal | 3 |
Bilateral, Cortex, Degeneration, | |
Diffuse, Fatty | 4 |
Bilateral, Cortex, Degeneration, | |
Fatty, Multifocal | 2 |
Bilateral, Cortex, Hyperplasia, | |
Multifocal | 2 2 2 3 |
Capsule, Hyperplasia, Focal | 2 |
Cortex, Cytoplasmic Alteration, Focal| 2 2 |
Cortex, Cytoplasmic Alteration, | |
Multifocal | 2 |
Cortex, Degeneration, Cystic, Focal | |
Cortex, Degeneration, Fatty, Focal | 2 2 3 3 2 |
Cortex, Degeneration, Fatty, | |
Multifocal | 2 |
Cortex, Hyperplasia, Focal | 2 2 4 2 |
Cortex, Hyperplasia, Multifocal | 2 |
Cortex, Karyomegaly, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2500 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cortex, Right, Atrophy, Multifocal | 3 |
Medulla, Cyst | |
Medulla, Karyomegaly, Focal | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + +|
Cyst, Multiple | X |
Pars Distalis, Cyst | X X X |
Pars Distalis, Cyst, Multiple | X X |
Pars Distalis, Hemorrhage, Focal | |
Pars Distalis, Hyperplasia, Focal | 3 |
Pars Distalis, Necrosis, Chronic, | |
Multifocal | 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
__________________________________________________________________________|
Ovary | + + |
Necrosis, Coagulative, Multifocal | 4 |
Periovarian Tissue, Cyst | X |
Periovarian Tissue, Right, Cyst | |
Periovarian Tissue, Left, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + |
Bilateral, Lumen, Ectasia | 3 |
Cervix, Diverticulum | X |
Cervix, Inflammation, Chronic Active,| |
Multifocal | |
Cervix, Prolapse, Multifocal | |
Endometrium, Hemorrhage, Multifocal | 3 |
Lumen, Hemorrhage, Focal, Subacute | 4 4 |
Lumen, Right, Ectasia, Focal | 4 |
Lumen, Right, Ectasia, Multifocal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + M + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous, | |
Multifocal | 3 |
Cortex, Mandibular, Cyst, Multiple | |
Mandibular, Hemorrhage, Multifocal | 2 |
Mandibular, Hyperplasia, Multifocal, | |
Plasma Cell | 2 3 3|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2500 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mandibular, Inflammation, Chronic, | |
Multifocal | |
Mandibular, Inflammation, | |
Granulomatous, Multifocal | 2 2 3 |
Mandibular, Pigmentation, | |
Hemosiderin, Multifocal | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Follicle, Depletion | |
Lymphoid, Multifocal | 3 3 |
Red Pulp, Congestion, Focal | 3 |
Red Pulp, Fibrosis, Focal | 3 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Multifocal | 2 3 3 3 2 3 2 2 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Multiple | 2 |
Red Pulp, Inflammation, Chronic | |
Active, Multifocal | |
Red Pulp, Inflammation, | |
Granulomatous, Multifocal | |
Red Pulp, Pigmentation, Hemosiderin, | |
Multifocal | 3 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + |
__________________________________________________________________________|
Skin | + |
Hindlimb, Subcutaneous Tissue, | |
Inflammation, Chronic Active, | |
Granulomatous | |
Hindlimb, Epidermis, Acanthosis, | |
Multifocal | |
Hindlimb, Epidermis, Hyperkeratosis, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + |
Congestion, Acute, Diffuse | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 0| 0| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2500 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Atrophy, Multifocal | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | |
Cortex, Left, Cyst, Single | |
__________________________________________________________________________|
Urinary Bladder | + |
Lumen, Calculus Gross Observation | X |
Mucosa, Hyperplasia, Chronic, | |
Multifocal | 3 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 7| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| |
| 0| 0| 0| 4| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 2| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
2500 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + | 23 |
Angiectasis, Multifocal | | 1 3.0|
Basophilic Focus, Multiple | X X X X X | 14 |
Basophilic Focus, Single | X X | 2 |
Clear Cell Focus | X | 2 |
Cyst | X | 1 |
Inflammation, Focal, Granulomatous | 2 2 | 2 2.0|
Inflammation, Granulomatous, | | |
Multifocal | 2 2 | 7 1.9|
Inflammation, Multifocal, Subacute | 2 | 2 2.0|
Bile Duct, Hyperplasia, Multifocal | 3 2 | 2 2.5|
Hepatocyte, Degeneration, Cystic, | | |
Focal | 3 | 3 2.7|
__________________________________________________________________________|____________|
Mesentery | M | |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
Acinus, Atrophy, Focal | 1 2 1 | 10 1.4|
Acinus, Atrophy, Multifocal | 2 2 1 1 2 2 2| 8 1.8|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Bilateral, Cortex, Atrophy, Diffuse | | 1 3.0|
Bilateral, Cortex, Congestion, | | |
Multifocal | | 1 3.0|
Bilateral, Cortex, Degeneration, | | |
Diffuse, Fatty | | 1 4.0|
Bilateral, Cortex, Degeneration, | | |
Fatty, Multifocal | 3 2 | 3 2.3|
Bilateral, Cortex, Hyperplasia, | | |
Multifocal | 2 2 2 | 7 2.1|
Capsule, Hyperplasia, Focal | | 1 2.0|
Cortex, Cytoplasmic Alteration, Focal| 2 | 3 2.0|
Cortex, Cytoplasmic Alteration, | | |
Multifocal | | 1 2.0|
Cortex, Degeneration, Cystic, Focal | 2 | 1 2.0|
Cortex, Degeneration, Fatty, Focal | 2 2 | 7 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 7| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| |
| 0| 0| 0| 4| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 2| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
2500 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Cortex, Degeneration, Fatty, | | |
Multifocal | | 1 2.0|
Cortex, Hyperplasia, Focal | 2 3| 6 2.5|
Cortex, Hyperplasia, Multifocal | 2 2 | 3 2.0|
Cortex, Karyomegaly, Focal | 3 | 2 2.5|
Cortex, Right, Atrophy, Multifocal | | 1 3.0|
Medulla, Cyst | X | 1 |
Medulla, Karyomegaly, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + +| 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + +| 32 |
Cyst, Multiple | | 1 |
Pars Distalis, Cyst | | 3 |
Pars Distalis, Cyst, Multiple | X X X X X | 7 |
Pars Distalis, Hemorrhage, Focal | 3 | 1 3.0|
Pars Distalis, Hyperplasia, Focal | | 1 3.0|
Pars Distalis, Necrosis, Chronic, | | |
Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | +| 2 |
__________________________________________________________________________|____________|
Ovary | + + + | 5 |
Necrosis, Coagulative, Multifocal | | 1 4.0|
Periovarian Tissue, Cyst | | 1 |
Periovarian Tissue, Right, Cyst | X | 1 |
Periovarian Tissue, Left, Cyst | X X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + | 10 |
Bilateral, Lumen, Ectasia | | 1 3.0|
Cervix, Diverticulum | | 1 |
Cervix, Inflammation, Chronic Active,| | |
Multifocal | 4 | 1 4.0|
Cervix, Prolapse, Multifocal | 3 | 1 3.0|
Endometrium, Hemorrhage, Multifocal | | 1 3.0|
Lumen, Hemorrhage, Focal, Subacute | | 2 4.0|
Lumen, Right, Ectasia, Focal | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 7| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| |
| 0| 0| 0| 4| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 2| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
2500 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Lumen, Right, Ectasia, Multifocal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + M + + + + + + + + + M + + + + + + +| 47 |
Inflammation, Granulomatous, | | |
Multifocal | | 1 3.0|
Cortex, Mandibular, Cyst, Multiple | X | 1 |
Mandibular, Hemorrhage, Multifocal | 1 2 2 1| 5 1.6|
Mandibular, Hyperplasia, Multifocal, | | |
Plasma Cell | 3 2 2 2 3| 8 2.5|
Mandibular, Inflammation, Chronic, | | |
Multifocal | 2 | 1 2.0|
Mandibular, Inflammation, | | |
Granulomatous, Multifocal | 2 2 2 3 | 7 2.3|
Mandibular, Pigmentation, | | |
Hemosiderin, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
Lymphoid Follicle, Depletion | | |
Lymphoid, Multifocal | | 2 3.0|
Red Pulp, Congestion, Focal | | 1 3.0|
Red Pulp, Fibrosis, Focal | | 1 3.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Multifocal | 2 2 2 2 2 3 3 2 3| 17 2.4|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Multiple | | 1 2.0|
Red Pulp, Inflammation, Chronic | | |
Active, Multifocal | 3 | 1 3.0|
Red Pulp, Inflammation, | | |
Granulomatous, Multifocal | 4 | 1 4.0|
Red Pulp, Pigmentation, Hemosiderin, | | |
Multifocal | | 3 2.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + +| 9 |
__________________________________________________________________________|____________|
Skin | + | 2 |
Hindlimb, Subcutaneous Tissue, | | |
Inflammation, Chronic Active, | | |
Granulomatous | 3 | 1 3.0|
Hindlimb, Epidermis, Acanthosis, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 7| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| |
| 0| 0| 0| 4| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 2| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
2500 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Multifocal | 3 | 1 3.0|
Hindlimb, Epidermis, Hyperkeratosis, | | |
Multifocal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 1 |
Congestion, Acute, Diffuse | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | A + | 1 |
Lens, Cataract | 4 | 1 4.0|
Retina, Atrophy, Multifocal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 1 |
Cortex, Left, Cyst, Single | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | | 1 |
Lumen, Calculus Gross Observation | | 1 |
Mucosa, Hyperplasia, Chronic, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 4| 2| 2| 2| 2| 1| 3| 2| 2| 2| 2| 2| 2| 4|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1| 8| 3| 8| 8| 6| 8| 3| 8| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A + + + + + + + + + + + + + + +|
Colon, Parasite Metazoan, Single | 2 |
Rectum, Parasite Metazoan, Single | 2 X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + A + + + + + + + + + + + + + + +|
Ileum, Peyer's Patch, Hyperplasia, | |
Lymphoid, Multifocal | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Multifocal | 2 |
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X X X X|
Basophilic Focus, Single | X |
Clear Cell Focus, Multiple | X |
Clear Cell Focus, Single | X |
Hyperplasia, Focal | 3 |
Inflammation, Focal, | |
Membranoproliferative | 1 |
Inflammation, Granulomatous, | |
Multifocal | 3 3 2 2 2 3 2 3 3 2 2 |
Bile Duct, Hyperplasia, Multifocal | 2 3 2 3 |
Centrilobular, Pigmentation, | |
Hemosiderin, Multifocal | 3 |
Hepatocyte, Necrosis, Acute, | |
Multifocal | 1 |
Hepatocyte, Necrosis, Multifocal | |
Hepatocyte, Vacuolization | |
Cytoplasmic, Multifocal | 3 4 |
Hepatocyte, Centrilobular, Necrosis, | |
Multifocal, Subacute | 4 |
Left Lateral Lobe, Angiectasis, Focal| |
Median Lobe, Atrophy, Chronic, | |
Multifocal | |
Periportal, Infiltration Cellular, | |
Acute, Multifocal, Lymphocyte | |
Sinusoid, Subserosa, Congestion, | |
Acute, Multifocal | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Granulomatous, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 4| 2| 2| 2| 2| 1| 3| 2| 2| 2| 2| 2| 2| 4|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1| 8| 3| 8| 8| 6| 8| 3| 8| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Acinus, Atrophy, Focal | 2 3|
Acinus, Atrophy, Multifocal | 2 2 4 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Hyperkeratosis, | |
Multifocal | 3 |
Forestomach, Hyperplasia, Multifocal,| |
Squamous | 3 |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Chronic Active, Multifocal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium Left, Thrombosis, Multifocal, | |
Subacute | X |
Myocardium, Degeneration, Chronic, | |
Multifocal | 2 2 3 2 2 2 3 2 2 3 3 2 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + I + + + + + +|
Bilateral, Cortex, Degeneration, | |
Fatty, Multifocal | 2 |
Bilateral, Cortex, Hyperplasia, | |
Multifocal | 2 |
Bilateral, Medulla, Hyperplasia, | |
Multifocal | |
Bilateral, Medulla, Infiltration | |
Cellular, Acute, Multifocal, | |
Lymphocyte | |
Cortex, Cytoplasmic Alteration, Focal| 2 |
Cortex, Degeneration, Fatty, Focal | 2 2 2|
Cortex, Degeneration, Fatty, | |
Multifocal | 2 |
Cortex, Hyperplasia, Focal | 2 3 2 3 2 3 2|
Cortex, Hyperplasia, Multifocal | 2 |
Cortex, Hypertrophy, Focal | |
Medulla, Hyperplasia, Focal | |
Medulla, Hyperplasia, Multifocal | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 4| 2| 2| 2| 2| 1| 3| 2| 2| 2| 2| 2| 2| 4|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1| 8| 3| 8| 8| 6| 8| 3| 8| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + M + + + + A + + + + + + + M M + + + + + +|
Hyperplasia, Glandular, Multifocal | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + A + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Cyst, Multiple | X X X |
Pars Distalis, Cyst, Single | X |
Pars Distalis, Hemorrhage, Multifocal| 3 3 |
Pars Distalis, Hemorrhage, | |
Multifocal, Subacute | |
Pars Distalis, Hyperplasia, Diffuse | 3 |
Pars Distalis, Hyperplasia, Focal | 2 |
Pars Distalis, Hyperplasia, | |
Multifocal | 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + A + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 3 |
C-Cell, Hyperplasia, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M M + + + M + + M + + + + + + M|
Cyst | |
Hyperplasia, Focal, Glandular | 2 |
Inflammation, Chronic Active, Focal | |
Inflammation, Multifocal, Suppurative| |
__________________________________________________________________________|
Ovary | + + + + + + + + + A + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicle, Cyst, Multiple | X X X |
Periovarian Tissue, Cyst | X |
Periovarian Tissue, Left, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Lumen, Ectasia, Multifocal| 3 |
Cervix, Diverticulum | |
Cervix, Fibrosis, Chronic, Multifocal| |
Cervix, Inflammation, Chronic Active,| |
Multifocal | |
Endometrium, Hyperplasia, Cystic, | |
Glandular, Multifocal | 2 2 2 2 1 2 2 2 2 3 2 1 2 2 2|
Lumen, Ectasia, Focal | 2 |
Lumen, Ectasia, Multifocal | 3 3 3|
Lumen, Right, Ectasia, Multifocal | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 4| 2| 2| 2| 2| 1| 3| 2| 2| 2| 2| 2| 2| 4|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1| 8| 3| 8| 8| 6| 8| 3| 8| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Lumen, Left, Ectasia, Focal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + |
Neutrophilia | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hyperplasia, Multifocal, Neutrophil | 2 4 |
Inflammation, Granulomatous, | |
Multifocal | |
Myelofibrosis, Multifocal | 3 |
Erythroid Cell, Hypoplasia, | |
Multifocal | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Angiectasis, Multifocal | |
Mandibular, Depletion Lymphoid, | |
Multifocal | 3 |
Mandibular, Hemorrhage, Multifocal | 2 2 3 2 3 3 3 2 2 2 3 |
Mandibular, Hyperplasia, Histiocytic,| |
Multifocal | 3 |
Mandibular, Hyperplasia, Lymphoid, | |
Multifocal | 2 |
Mandibular, Hyperplasia, Multifocal, | |
Plasma Cell | 3 |
Mandibular, Inflammation, Chronic, | |
Multifocal | |
Mandibular, Inflammation, | |
Granulomatous, Multifocal | 2 2 4 |
Mandibular, Pigmentation, | |
Hemosiderin, Multifocal | |
Mediastinal, Hemorrhage, Multifocal | 4 |
Mediastinal, Inflammation, Chronic, | |
Multifocal | |
Mediastinal, Inflammation, | |
Granulomatous, Multifocal | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Follicle, Depletion | |
Lymphoid, Multifocal | 4 |
Red Pulp, Hematopoietic Cell | |
Proliferation, Multifocal | 2 2 2 2 2 3 2 3 2 2 4 3 3 2 2 3 2|
Red Pulp, Inflammation, | |
Granulomatous, Multifocal | |
Red Pulp, Necrosis, Acute, Multifocal| |
Red Pulp, Pigmentation, Hemosiderin, | |
Multifocal | 3 3 |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 4| 2| 2| 2| 2| 1| 3| 2| 2| 2| 2| 2| 2| 4|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1| 8| 3| 8| 8| 6| 8| 3| 8| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + M + + + + + + + + + + + +|
Depletion Lymphoid, Multifocal | 3 2 2 3 3 3 2 2 2 3 3 2 2 3 2 2 2|
Pigmentation, Hemosiderin, Multifocal| 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M M + + + + + + + + + + + + + +|
Acinus, Hyperplasia, Cystic, | |
Multifocal | 3 3 2 3 2 2 2 2 3 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abdominal, Ulcer, Acute, Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Osteopetrosis, Multifocal | 3 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + A + + + + + + + + + + + + + + |
Cerebellum, Hemorrhage, Multifocal | |
Cerebrum, Compression, Focal | 3 3 |
Cerebrum, Hemorrhage, Focal | |
Cerebrum, Perivascular Cuffing, Focal| |
Medulla, Hemorrhage, Focal | 3 |
Ventricle, Hydrocephalus, Multifocal | 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin, Multifocal| |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 4 |
Bronchiole, Epithelium, Hyperplasia, | |
Multifocal | |
Interstitium, Inflammation, Acute, | |
Multifocal | 2 |
Interstitium, Inflammation, Chronic, | |
Focal | 1 |
Interstitium, Inflammation, | |
Multifocal, Subacute | |
__________________________________________________________________________|
Nose | + + + + + + + + + M + + + + M + + M + + + + + + M|
Nasolacrimal Duct, Inflammation, | |
Focal, Subacute | 2 3 |
Nasolacrimal Duct, Inflammation, | |
Multifocal, Subacute | 3 3 3 |
Respiratory Epithelium, Degeneration,| |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 4| 2| 2| 2| 2| 1| 3| 2| 2| 2| 2| 2| 2| 4|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1| 8| 3| 8| 8| 6| 8| 3| 8| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Multifocal | 2 2 2 2 1 2 2 2 2 2 |
Submucosa, Respiratory Epithelium, | |
Inflammation, Multifocal, | |
Subacute | 2 2 2 3 2 2 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + I + + + + + + + + +|
Wall, Hemorrhage, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Lens, Cataract | 3 4 |
Retina, Atrophy, Multifocal | 4 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + |
Inflammation, Focal, Subacute | |
Inflammation, Multifocal, Subacute | 2 2 2 2 |
Bilateral, Inflammation, Multifocal, | |
Subacute | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + A + + + + + + + + + + + + + + +|
Bilateral, Nephropathy, Chronic, | |
Multifocal | 2 1 3 2 2 2 1 2 1 1 2 3 2 1 2 |
Bilateral, Nephropathy, Multifocal | 1 |
Cortex, Infarct, Focal | |
Cortex, Inflammation, Chronic, Focal | |
Cortex, Left, Cyst, Single | X |
Renal Tubule, Degeneration, Acute, | |
Multifocal | 3 |
Renal Tubule, Hyperplasia, Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Mucosa, Hyperplasia, Multifocal | |
Mucosa, Hyperplasia, Multifocal, | |
Squamous | 4 |
Mucosa, Metaplasia, Multifocal, | |
Squamous | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 3| 7| |
DAY ON TEST | 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 4| 2| |
| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 3| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
5000 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Colon, Parasite Metazoan, Single | | 1 2.0|
Rectum, Parasite Metazoan, Single | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ileum, Peyer's Patch, Hyperplasia, | | |
Lymphoid, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Multifocal | | 1 2.0|
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X X X X X X X X| 42 |
Basophilic Focus, Single | | 1 |
Clear Cell Focus, Multiple | | 1 |
Clear Cell Focus, Single | X X | 3 |
Hyperplasia, Focal | | 1 3.0|
Inflammation, Focal, | | |
Membranoproliferative | | 1 1.0|
Inflammation, Granulomatous, | | |
Multifocal | 2 2 3 2 2 2 2 2 2 2 2| 22 2.3|
Bile Duct, Hyperplasia, Multifocal | 3 2 2| 7 2.4|
Centrilobular, Pigmentation, | | |
Hemosiderin, Multifocal | | 1 3.0|
Hepatocyte, Necrosis, Acute, | | |
Multifocal | | 1 1.0|
Hepatocyte, Necrosis, Multifocal | 2 2 | 2 2.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Multifocal | 3 3 3 2 | 6 3.0|
Hepatocyte, Centrilobular, Necrosis, | | |
Multifocal, Subacute | | 1 4.0|
Left Lateral Lobe, Angiectasis, Focal| 4 | 1 4.0|
Median Lobe, Atrophy, Chronic, | | |
Multifocal | 3 | 1 3.0|
Periportal, Infiltration Cellular, | | |
Acute, Multifocal, Lymphocyte | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 3| 7| |
DAY ON TEST | 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 4| 2| |
| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 3| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
5000 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Sinusoid, Subserosa, Congestion, | | |
Acute, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Inflammation, Granulomatous, | | |
Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 1 2.0|
Acinus, Atrophy, Focal | | 2 2.5|
Acinus, Atrophy, Multifocal | 2 2 3 | 6 2.5|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Forestomach, Hyperkeratosis, | | |
Multifocal | | 1 3.0|
Forestomach, Hyperplasia, Multifocal,| | |
Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Peridontal Tissue, Inflammation, | | |
Chronic Active, Multifocal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium Left, Thrombosis, Multifocal, | | |
Subacute | | 1 |
Myocardium, Degeneration, Chronic, | | |
Multifocal | 2 2 2 2 2 2 3 2 2 2 3 2 2 3 1 3 3 3 3 2 2| 38 2.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Bilateral, Cortex, Degeneration, | | |
Fatty, Multifocal | | 1 2.0|
Bilateral, Cortex, Hyperplasia, | | |
Multifocal | 3 | 2 2.5|
Bilateral, Medulla, Hyperplasia, | | |
Multifocal | 2 2 | 2 2.0|
Bilateral, Medulla, Infiltration | | |
Cellular, Acute, Multifocal, | | |
Lymphocyte | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 3| 7| |
DAY ON TEST | 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 4| 2| |
| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 3| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
5000 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Cortex, Cytoplasmic Alteration, Focal| | 1 2.0|
Cortex, Degeneration, Fatty, Focal | 3 2 2| 6 2.2|
Cortex, Degeneration, Fatty, | | |
Multifocal | 3 2 | 3 2.3|
Cortex, Hyperplasia, Focal | 2 3 3 3 | 11 2.5|
Cortex, Hyperplasia, Multifocal | 2| 2 2.0|
Cortex, Hypertrophy, Focal | 3 | 1 3.0|
Medulla, Hyperplasia, Focal | 2 2 | 2 2.0|
Medulla, Hyperplasia, Multifocal | 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + + M + M + + M + + + I M| 39 |
Hyperplasia, Glandular, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + I + + + + + + +| 48 |
Pars Distalis, Cyst | | 2 |
Pars Distalis, Cyst, Multiple | X X X | 6 |
Pars Distalis, Cyst, Single | | 1 |
Pars Distalis, Hemorrhage, Multifocal| 4 2 | 4 3.0|
Pars Distalis, Hemorrhage, | | |
Multifocal, Subacute | 3 3 | 2 3.0|
Pars Distalis, Hyperplasia, Diffuse | | 1 3.0|
Pars Distalis, Hyperplasia, Focal | 3 | 2 2.5|
Pars Distalis, Hyperplasia, | | |
Multifocal | 3 2| 4 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia, Focal | | 1 3.0|
C-Cell, Hyperplasia, Multifocal | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 | 25 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + + I + + + + + + M + + + + M + + + + + M +| 40 |
Cyst | X | 1 |
Hyperplasia, Focal, Glandular | 2 3 | 3 2.3|
Inflammation, Chronic Active, Focal | 2 | 1 2.0|
Inflammation, Multifocal, Suppurative| 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 3| 7| |
DAY ON TEST | 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 4| 2| |
| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 3| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
5000 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Follicle, Cyst | X X | 2 |
Follicle, Cyst, Multiple | X X | 5 |
Periovarian Tissue, Cyst | X X | 3 |
Periovarian Tissue, Left, Cyst | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Lumen, Ectasia, Multifocal| | 1 3.0|
Cervix, Diverticulum | X | 1 |
Cervix, Fibrosis, Chronic, Multifocal| 4 | 1 4.0|
Cervix, Inflammation, Chronic Active,| | |
Multifocal | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular, Multifocal | 2 2 2 2 1 1 2 2 2 2 2 2 2 2 2 2 3| 32 1.9|
Lumen, Ectasia, Focal | | 1 2.0|
Lumen, Ectasia, Multifocal | 3 4 | 5 3.2|
Lumen, Right, Ectasia, Multifocal | 3| 1 3.0|
Lumen, Left, Ectasia, Focal | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + | 8 |
Neutrophilia | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Multifocal, Neutrophil | 3 | 3 3.0|
Inflammation, Granulomatous, | | |
Multifocal | 2 | 1 2.0|
Myelofibrosis, Multifocal | 4 | 2 3.5|
Erythroid Cell, Hypoplasia, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mandibular, Angiectasis, Multifocal | 2 | 1 2.0|
Mandibular, Depletion Lymphoid, | | |
Multifocal | | 1 3.0|
Mandibular, Hemorrhage, Multifocal | 2 2 3 1 2 | 16 2.3|
Mandibular, Hyperplasia, Histiocytic,| | |
Multifocal | | 1 3.0|
Mandibular, Hyperplasia, Lymphoid, | | |
Multifocal | 3 3 | 3 2.7|
Mandibular, Hyperplasia, Multifocal, | | |
Plasma Cell | 3 | 2 3.0|
Mandibular, Inflammation, Chronic, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 3| 7| |
DAY ON TEST | 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 4| 2| |
| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 3| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
5000 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Multifocal | 3 3 2 2 | 4 2.5|
Mandibular, Inflammation, | | |
Granulomatous, Multifocal | 3 | 4 2.8|
Mandibular, Pigmentation, | | |
Hemosiderin, Multifocal | 3 | 1 3.0|
Mediastinal, Hemorrhage, Multifocal | 2 | 2 3.0|
Mediastinal, Inflammation, Chronic, | | |
Multifocal | 4 | 1 4.0|
Mediastinal, Inflammation, | | |
Granulomatous, Multifocal | 2 3| 4 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoid Follicle, Depletion | | |
Lymphoid, Multifocal | | 1 4.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Multifocal | 3 3 3 3 2 2 3 3 3 2 2 2 3 | 30 2.5|
Red Pulp, Inflammation, | | |
Granulomatous, Multifocal | 4 4 | 2 4.0|
Red Pulp, Necrosis, Acute, Multifocal| 4 | 1 4.0|
Red Pulp, Pigmentation, Hemosiderin, | | |
Multifocal | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +| 47 |
Depletion Lymphoid, Multifocal | 2 2 2 3 2 3 3 2 3 3 3 3 3 3 3 3 3 3 3| 36 2.6|
Pigmentation, Hemosiderin, Multifocal| | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + M +| 46 |
Acinus, Hyperplasia, Cystic, | | |
Multifocal | 3 2 3 3 2 3 2 3 3 2 2 2 3 3 2 3 | 27 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abdominal, Ulcer, Acute, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femur, Osteopetrosis, Multifocal | 4 3 2 3 2 4 2 2 3 | 11 2.8|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cerebellum, Hemorrhage, Multifocal | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 3| 7| |
DAY ON TEST | 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 4| 2| |
| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 3| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
5000 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Cerebrum, Compression, Focal | 3 3 3 2 3 | 7 2.9|
Cerebrum, Hemorrhage, Focal | 2 | 1 2.0|
Cerebrum, Perivascular Cuffing, Focal| 2 | 1 2.0|
Medulla, Hemorrhage, Focal | | 1 3.0|
Ventricle, Hydrocephalus, Multifocal | 2 2 3 | 5 2.2|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pigmentation, Hemosiderin, Multifocal| 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 3.5|
Bronchiole, Epithelium, Hyperplasia, | | |
Multifocal | 3 | 1 3.0|
Interstitium, Inflammation, Acute, | | |
Multifocal | | 1 2.0|
Interstitium, Inflammation, Chronic, | | |
Focal | | 1 1.0|
Interstitium, Inflammation, | | |
Multifocal, Subacute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + M + + + + + + +| 45 |
Nasolacrimal Duct, Inflammation, | | |
Focal, Subacute | 3 2 2 2 2 | 7 2.3|
Nasolacrimal Duct, Inflammation, | | |
Multifocal, Subacute | 2 2 2 3 2 2 | 9 2.4|
Respiratory Epithelium, Degeneration,| | |
Multifocal | 2 2 3 2 2 2 2| 17 2.0|
Submucosa, Respiratory Epithelium, | | |
Inflammation, Multifocal, | | |
Subacute | 2 3 2 2 2 2 2 2 2 2 2 2 2 2| 24 2.1|
__________________________________________________________________________|____________|
Trachea | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
Wall, Hemorrhage, Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 4 |
Lens, Cataract | 3 | 3 3.3|
Retina, Atrophy, Multifocal | 4 | 3 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + +| 42 |
Inflammation, Focal, Subacute | 2 2 | 2 2.0|
Inflammation, Multifocal, Subacute | 2 2 2 2 | 8 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 3| 7| |
DAY ON TEST | 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 4| 2| |
| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 3| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
5000 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Bilateral, Inflammation, Multifocal, | | |
Subacute | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Bilateral, Nephropathy, Chronic, | | |
Multifocal | 3 2 2 3 2 1 1 1 3 2 2 1 2 3 1 1 2 1 | 33 1.8|
Bilateral, Nephropathy, Multifocal | | 1 1.0|
Cortex, Infarct, Focal | 3 | 1 3.0|
Cortex, Inflammation, Chronic, Focal | 3 | 1 3.0|
Cortex, Left, Cyst, Single | | 1 |
Renal Tubule, Degeneration, Acute, | | |
Multifocal | | 1 3.0|
Renal Tubule, Hyperplasia, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Calculus Micro Observation Only | X | 1 |
Mucosa, Hyperplasia, Multifocal | 2 | 1 2.0|
Mucosa, Hyperplasia, Multifocal, | | |
Squamous | | 1 4.0|
Mucosa, Metaplasia, Multifocal, | | |
Squamous | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 4| 6| 6|
DAY ON TEST | 9| 7| 2| 7| 2| 2| 5| 2| 2| 2| 2| 4| 5| 2| 2| 8| 2| 2| 2| 7| 2| 2| 1| 7| 5|
| 8| 1| 7| 4| 7| 7| 8| 7| 7| 7| 7| 8| 6| 7| 7| 0| 7| 7| 7| 1| 7| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + A + + + + + + + + + + + + + + + + + + + + A + +|
Rectum, Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Small | + A + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 2 |
Angiectasis, Multifocal | 2 |
Basophilic Focus | X |
Basophilic Focus, Focal | X |
Basophilic Focus, Multiple | X X X X X X X X |
Basophilic Focus, Single | X |
Clear Cell Focus | |
Clear Cell Focus, Multiple | |
Eosinophilic Focus, Multiple | X |
Eosinophilic Focus, Single | |
Hyperplasia, Focal | |
Inflammation, Granulomatous, | |
Multifocal | 2 2 |
Mixed Cell Focus | X |
Bile Duct, Hyperplasia, Chronic, | |
Multifocal | |
Bile Duct, Hyperplasia, Multifocal | 3 3 2 2 2 2 2 2 3 3 2 2 4 2 3 4|
Bile Duct, Hyperplasia, Multifocal, | |
Nodular | 3 |
Hepatocyte, Cytoplasmic Alteration, | |
Focal | 2 |
Hepatocyte, Degeneration, Cystic, | |
Focal | 2 3 2 2 2 3|
Hepatocyte, Degeneration, Cystic, | |
Multifocal | 1 3 2 |
Hepatocyte, Necrosis, Multifocal, | |
Subacute | 3 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Multifocal | 2 3 4 |
__________________________________________________________________________|
Mesentery | + + M |
Fat, Necrosis, Acute, Multifocal | 2 |
Fat, Necrosis, Chronic, Multifocal | |
__________________________________________________________________________|
Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 4| 6| 6|
DAY ON TEST | 9| 7| 2| 7| 2| 2| 5| 2| 2| 2| 2| 4| 5| 2| 2| 8| 2| 2| 2| 7| 2| 2| 1| 7| 5|
| 8| 1| 7| 4| 7| 7| 8| 7| 7| 7| 7| 8| 6| 7| 7| 0| 7| 7| 7| 1| 7| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acinus, Atrophy, Focal | 1 1 |
Acinus, Atrophy, Multifocal | 2 2 1 1 1 2 2 3 3 3 4 2 |
Acinus, Cytoplasmic Alteration, Focal| |
Duct, Ectasia, Focal | |
Duct, Ectasia, Multifocal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 2 |
Acinus, Atrophy, Multifocal | |
__________________________________________________________________________|
Stomach | + A + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Acanthosis, Multifocal | 2 |
Forestomach, Hyperkeratosis, | |
Multifocal | 2 |
Forestomach, Ulcer, Focal, Subacute | 3 |
Forestomach, Ulcer, Multifocal, | |
Subacute | 3 |
Forestomach, Muscularis, | |
Mineralization, Multifocal | |
Glandular, Necrosis, Acute, Focal | 2 |
Glandular, Ulcer, Acute, Multifocal | 2 |
Glandular, Ulcer, Focal, Subacute | 3 |
Muscularis, Glandular, | |
Mineralization, Multifocal | |
Submucosa, Glandular, Inflammation, | |
Multifocal, Subacute | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Mineralization, Multifocal | |
Atrium Left, Thrombosis, Single | |
Myocardium, Degeneration, Chronic, | |
Multifocal | 2 3 3 2 3 3 2 3 3 3 2 3 3 3 3 3 3 3 2 2 3 2|
Myocardium, Degeneration, Multifocal | 2 |
Myocardium, Inflammation, Chronic, | |
Multifocal | |
Myocardium, Mineralization, | |
Multifocal | |
Ventricle Left, Thrombosis, Chronic, | |
Focal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Cortex, Hyperplasia, | |
Multifocal | 2 |
Bilateral, Cortex, Vacuolization | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 4| 6| 6|
DAY ON TEST | 9| 7| 2| 7| 2| 2| 5| 2| 2| 2| 2| 4| 5| 2| 2| 8| 2| 2| 2| 7| 2| 2| 1| 7| 5|
| 8| 1| 7| 4| 7| 7| 8| 7| 7| 7| 7| 8| 6| 7| 7| 0| 7| 7| 7| 1| 7| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cytoplasmic, Multifocal | 3 |
Bilateral, Medulla, Hyperplasia, | |
Multifocal | |
Cortex, Cytoplasmic Alteration, Focal| 1 |
Cortex, Degeneration, Fatty, Focal | 2 2 2 2|
Cortex, Degeneration, Fatty, | |
Multifocal | 2 2 |
Cortex, Hematopoietic Cell | |
Proliferation, Multifocal | |
Cortex, Hyperplasia, Focal | 2 2 2 2 2 |
Cortex, Hyperplasia, Multifocal | |
Cortex, Nuclear Alteration, Focal | 2 |
Cortex, Vacuolization Cytoplasmic, | |
Diffuse | 4 |
Cortex, Vacuolization Cytoplasmic, | |
Multifocal | 3 |
Medulla, Cyst, Single | X |
Medulla, Hyperplasia, Focal | 2 2 2 2 |
Medulla, Hyperplasia, Multifocal | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + I + M + M + + + M + +|
Cytoplasmic Alteration, Focal | |
Hyperplasia, Diffuse | 2 |
Hyperplasia, Focal | |
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 2 3 |
Pars Intermedia, Cyst | X |
Pars Intermedia, Cyst, Multiple | X |
__________________________________________________________________________|
Thyroid Gland | + A + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 2 2 |
C-Cell, Hyperplasia, Multifocal | 2 2 2 2 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + M + + + + + + + M + + M + +|
Abscess | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 4| 6| 6|
DAY ON TEST | 9| 7| 2| 7| 2| 2| 5| 2| 2| 2| 2| 4| 5| 2| 2| 8| 2| 2| 2| 7| 2| 2| 1| 7| 5|
| 8| 1| 7| 4| 7| 7| 8| 7| 7| 7| 7| 8| 6| 7| 7| 0| 7| 7| 7| 1| 7| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia, Focal, Glandular | |
Hyperplasia, Glandular, Multifocal | |
Infiltration Cellular, Mononuclear | |
Cell, Mononuclear Cell, | |
Multifocal | 3 |
Inflammation, Chronic, Multifocal | 2 |
Inflammation, Chronic Active, | |
Multifocal | 4 3 |
Inflammation, Multifocal, Subacute | 1 2 |
Bilateral, Hyperplasia, Glandular, | |
Multifocal | |
Bilateral, Inflammation, Chronic | |
Active, Multifocal | 3 2 2 2 2 2 2 2 2 2|
Bilateral, Duct, Ectasia, Focal | 3 |
Bilateral, Duct, Ectasia, Multifocal | |
Duct, Ectasia, Multifocal | |
Duct, Right, Ectasia, Diffuse | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + M + + + + M + + + + + + + +|
Inflammation, Chronic, Multifocal | 3 2 |
Inflammation, Chronic, Multifocal, | |
Suppurative | |
Inflammation, Granulomatous, | |
Multifocal | 3 |
Inflammation, Multifocal, Subacute | 2 2 |
Epithelium, Hyperplasia, Multifocal | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Atrophy, Multifocal | 3 |
Bilateral, Interstitial Cell, | |
Hyperplasia, Multifocal | 2 |
Bilateral, Seminiferous Tubule, | |
Atrophy, Multifocal | 3 3 3 3 4 4 4 3 3 4 3 |
Interstitial Cell, Right, | |
Hyperplasia, Multifocal | 2 |
Interstitial Cell, Left, Hyperplasia,| |
Multifocal | 3 |
Seminiferous Tubule, Atrophy, | |
Multifocal | 3 3 3 2 |
Seminiferous Tubule, Right, Atrophy, | |
Multifocal | 4 4 |
Seminiferous Tubule, Left, Atrophy, | |
Multifocal | 2 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 4| 6| 6|
DAY ON TEST | 9| 7| 2| 7| 2| 2| 5| 2| 2| 2| 2| 4| 5| 2| 2| 8| 2| 2| 2| 7| 2| 2| 1| 7| 5|
| 8| 1| 7| 4| 7| 7| 8| 7| 7| 7| 7| 8| 6| 7| 7| 0| 7| 7| 7| 1| 7| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Neutrophilia | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + A + +|
Hyperplasia, Multifocal, Neutrophil | 4 2 |
Myelofibrosis, Multifocal | |
Myeloid Cell, Erythroid Cell, | |
Hypoplasia, Multifocal | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid, Multifocal | 3 |
Mandibular, Cyst | X |
Mandibular, Hemorrhage, Multifocal | 3 |
Mandibular, Hyperplasia, Lymphoid, | |
Multifocal | 2 2 3 |
Mandibular, Infiltration Cellular, | |
Multifocal, Plasma Cell | |
Mandibular, Inflammation, Chronic, | |
Multifocal | 2 |
Mediastinal, Hemorrhage, Multifocal | 2 2 |
Mediastinal, Hyperplasia, Lymphoid, | |
Multifocal | |
Mediastinal, Inflammation, | |
Granulomatous, Multifocal | |
Mediastinal, Inflammation, | |
Multifocal, Subacute | |
Mesenteric, Cyst | |
Mesenteric, Cyst, Multiple | |
Mesenteric, Hemorrhage, Multifocal | |
Mesenteric, Hyperplasia, Lymphoid, | |
Multifocal | 2 |
Mesenteric, Inflammation, Chronic, | |
Multifocal | 2 |
Mesenteric, Inflammation, | |
Granulomatous, Multifocal | 2 |
Pancreatic, Cyst | X |
Pancreatic, Hemorrhage, Multifocal | 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Diffuse, Subacute | 3 |
Red Pulp, Fibrosis, Chronic, | |
Multifocal | 3 |
Red Pulp, Fibrosis, Focal | |
Red Pulp, Fibrosis, Multifocal | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Multifocal | 3 |
Red Pulp, Pigmentation, Hemosiderin, | |
Multifocal | 3 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 4| 6| 6|
DAY ON TEST | 9| 7| 2| 7| 2| 2| 5| 2| 2| 2| 2| 4| 5| 2| 2| 8| 2| 2| 2| 7| 2| 2| 1| 7| 5|
| 8| 1| 7| 4| 7| 7| 8| 7| 7| 7| 7| 8| 6| 7| 7| 0| 7| 7| 7| 1| 7| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | I + + + + + + + + + + M + + M M + + + + + + I + +|
Depletion Lymphoid, Multifocal | 3 2 3 3 2 2 3 3 3 3 3 2 3 2|
Artery, Mediastinum, Inflammation, | |
Chronic, Multifocal, | |
Proliferative | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + M + + + + + M + M + M M + M +|
Acinus, Hyperplasia, Cystic, | |
Multifocal | 3 3 2 2 1 2 4 2 1 3 2 3|
Acinus, Hyperplasia, Multifocal | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Ulcer, Chronic Active, | |
Focal | 3 |
Tail, Hyperkeratosis, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Osteopetrosis, Multifocal | 3 3|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Hemorrhage, Acute, | |
Multifocal | 3|
Cerebrum, Hemorrhage, Acute, | |
Multifocal | 3|
Cerebrum, Hemorrhage, Focal | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous, | |
Multifocal | |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 3 3 |
Bronchiole, Epithelium, Hyperplasia, | |
Multifocal | 2 |
Interstitium, Inflammation, Chronic, | |
Multifocal | |
Interstitium, Metaplasia, Focal, | |
Osseous | |
Interstitium, Mineralization, | |
Multifocal | |
__________________________________________________________________________|
Nose | M + + + + + + + + + + M + + + + + + + M + + M + +|
Nasolacrimal Duct, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 4| 6| 6|
DAY ON TEST | 9| 7| 2| 7| 2| 2| 5| 2| 2| 2| 2| 4| 5| 2| 2| 8| 2| 2| 2| 7| 2| 2| 1| 7| 5|
| 8| 1| 7| 4| 7| 7| 8| 7| 7| 7| 7| 8| 6| 7| 7| 0| 7| 7| 7| 1| 7| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Chronic, Multifocal | |
Nasolacrimal Duct, Inflammation, | |
Focal, Subacute | 2 2 2|
Nasolacrimal Duct, Inflammation, | |
Multifocal | |
Nasolacrimal Duct, Inflammation, | |
Multifocal, Subacute | 2 2 3 2 2 3 2 3 2 2 2 |
Respiratory Epithelium, Degeneration,| |
Multifocal | 1 2 2 1 3 1 2 2 2 2 1 3 2 2 1 1|
Respiratory Epithelium, Inflammation,| |
Chronic, Focal | 2|
Respiratory Epithelium, Inflammation,| |
Multifocal, Subacute | |
Respiratory Epithelium, Metaplasia, | |
Multifocal, Squamous | 2 |
Submucosa, Olfactory Epithelium, | |
Inflammation, Multifocal, | |
Subacute | 2 |
Submucosa, Respiratory Epithelium, | |
Inflammation, Acute, Multifocal | 2 |
Submucosa, Respiratory Epithelium, | |
Inflammation, Chronic, | |
Multifocal | 2 |
Submucosa, Respiratory Epithelium, | |
Inflammation, Multifocal | 2 |
Submucosa, Respiratory Epithelium, | |
Inflammation, Multifocal, | |
Subacute | 2 3 3 3 2 2 3 3 2 2 |
Submucosa, Respiratory Epithelium, | |
Inflammation, Multifocal, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + A + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + M + M + |
Cornea, Inflammation, Multifocal, | |
Subacute | 2 |
Lens, Cataract, Multifocal | 3 3 |
Retina, Atrophy, Multifocal | 4 3 3 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Glandular, Multifocal | |
__________________________________________________________________________|
Zymbal's Gland | M |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 4| 6| 6|
DAY ON TEST | 9| 7| 2| 7| 2| 2| 5| 2| 2| 2| 2| 4| 5| 2| 2| 8| 2| 2| 2| 7| 2| 2| 1| 7| 5|
| 8| 1| 7| 4| 7| 7| 8| 7| 7| 7| 7| 8| 6| 7| 7| 0| 7| 7| 7| 1| 7| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Multiple | X |
Bilateral, Nephropathy, Chronic, | |
Multifocal | 2 3 4 3 3 3 2 4 4 4 4 1 4 4 3 4 2 4 2 4 4 2 4 2|
Cortex, Cyst | X |
Cortex, Cyst, Multiple | X |
Cortex, Cyst, Single | X |
Left, Nephropathy, Chronic, | |
Multifocal | 2 |
Papilla, Epithelium, Hyperplasia, | |
Multifocal | |
Renal Tubule, Pigmentation, | |
Multifocal | 3 |
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + + + M + + + + + + + +|
Mucosa, Hyperplasia, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| |
DAY ON TEST | 1| 2| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 6| |
| 3| 7| 7| 5| 7| 0| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + A + + +| 47 |
Rectum, Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + +| 40 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + A + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 2 3 | 4 2.3|
Angiectasis, Multifocal | | 1 2.0|
Basophilic Focus | | 1 |
Basophilic Focus, Focal | | 1 |
Basophilic Focus, Multiple | X X X X X X | 14 |
Basophilic Focus, Single | X | 2 |
Clear Cell Focus | X | 1 |
Clear Cell Focus, Multiple | X | 1 |
Eosinophilic Focus, Multiple | X X | 3 |
Eosinophilic Focus, Single | X | 1 |
Hyperplasia, Focal | 2 | 1 2.0|
Inflammation, Granulomatous, | | |
Multifocal | 2 2 2 | 5 2.0|
Mixed Cell Focus | | 1 |
Bile Duct, Hyperplasia, Chronic, | | |
Multifocal | 4 | 1 4.0|
Bile Duct, Hyperplasia, Multifocal | 3 2 2 3 3 2 3 3 3 4 2 3 2 2 4 3 3 3 3| 35 2.7|
Bile Duct, Hyperplasia, Multifocal, | | |
Nodular | | 1 3.0|
Hepatocyte, Cytoplasmic Alteration, | | |
Focal | | 1 2.0|
Hepatocyte, Degeneration, Cystic, | | |
Focal | 2 3 2 3 | 10 2.4|
Hepatocyte, Degeneration, Cystic, | | |
Multifocal | 4 2 3 3 2 2 | 9 2.4|
Hepatocyte, Necrosis, Multifocal, | | |
Subacute | | 1 3.0|
Hepatocyte, Vacuolization | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| |
DAY ON TEST | 1| 2| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 6| |
| 3| 7| 7| 5| 7| 0| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Cytoplasmic, Multifocal | 4 4 3 3 3| 8 3.3|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis, Acute, Multifocal | | 1 2.0|
Fat, Necrosis, Chronic, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy, Focal | | 2 1.0|
Acinus, Atrophy, Multifocal | 3 2 2 2 2 2 2 2 2 2 4 3 2 2 2| 27 2.2|
Acinus, Cytoplasmic Alteration, Focal| 2 2 | 2 2.0|
Duct, Ectasia, Focal | 2 | 1 2.0|
Duct, Ectasia, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy, Focal | | 1 2.0|
Acinus, Atrophy, Multifocal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Forestomach, Acanthosis, Multifocal | 2 | 2 2.0|
Forestomach, Hyperkeratosis, | | |
Multifocal | | 1 2.0|
Forestomach, Ulcer, Focal, Subacute | | 1 3.0|
Forestomach, Ulcer, Multifocal, | | |
Subacute | | 1 3.0|
Forestomach, Muscularis, | | |
Mineralization, Multifocal | 4 | 1 4.0|
Glandular, Necrosis, Acute, Focal | | 1 2.0|
Glandular, Ulcer, Acute, Multifocal | | 1 2.0|
Glandular, Ulcer, Focal, Subacute | | 1 3.0|
Muscularis, Glandular, | | |
Mineralization, Multifocal | 4 | 1 4.0|
Submucosa, Glandular, Inflammation, | | |
Multifocal, Subacute | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Mineralization, Multifocal | 2 | 1 2.0|
Atrium Left, Thrombosis, Single | X X | 2 |
Myocardium, Degeneration, Chronic, | | |
Multifocal | 2 2 2 2 2 3 2 2 3 3 3 3 3 3 2 3 2 2 2 3 4 2 2 2| 46 2.6|
Myocardium, Degeneration, Multifocal | | 1 2.0|
Myocardium, Inflammation, Chronic, | | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| |
DAY ON TEST | 1| 2| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 6| |
| 3| 7| 7| 5| 7| 0| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Myocardium, Mineralization, | | |
Multifocal | 3 | 1 3.0|
Ventricle Left, Thrombosis, Chronic, | | |
Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Cortex, Hyperplasia, | | |
Multifocal | 3 2 | 3 2.3|
Bilateral, Cortex, Vacuolization | | |
Cytoplasmic, Multifocal | | 1 3.0|
Bilateral, Medulla, Hyperplasia, | | |
Multifocal | 2 | 1 2.0|
Cortex, Cytoplasmic Alteration, Focal| | 1 1.0|
Cortex, Degeneration, Fatty, Focal | 2 | 5 2.0|
Cortex, Degeneration, Fatty, | | |
Multifocal | 3 2 2 | 5 2.2|
Cortex, Hematopoietic Cell | | |
Proliferation, Multifocal | 2 | 1 2.0|
Cortex, Hyperplasia, Focal | 2 | 6 2.0|
Cortex, Hyperplasia, Multifocal | 2 | 1 2.0|
Cortex, Nuclear Alteration, Focal | | 1 2.0|
Cortex, Vacuolization Cytoplasmic, | | |
Diffuse | | 1 4.0|
Cortex, Vacuolization Cytoplasmic, | | |
Multifocal | 2 2 2 | 4 2.3|
Medulla, Cyst, Single | | 1 |
Medulla, Hyperplasia, Focal | 2 2 | 6 2.0|
Medulla, Hyperplasia, Multifocal | 2 2 2 2 3 2 | 6 2.2|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + | 14 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + + + + M + + + + + M + +| 42 |
Cytoplasmic Alteration, Focal | 3 | 1 3.0|
Hyperplasia, Diffuse | | 1 2.0|
Hyperplasia, Focal | 3 | 1 3.0|
Hyperplasia, Multifocal | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Pars Distalis, Cyst | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| |
DAY ON TEST | 1| 2| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 6| |
| 3| 7| 7| 5| 7| 0| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Hyperplasia, Focal | 2 2 3 2 1 | 7 2.1|
Pars Intermedia, Cyst | X | 2 |
Pars Intermedia, Cyst, Multiple | X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia, Focal | 2 2 2 | 6 2.0|
C-Cell, Hyperplasia, Multifocal | 2| 5 2.0|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + M + + + + + + + + + + + + + + + M| 43 |
Abscess | X | 1 |
Hyperplasia, Focal, Glandular | 2 | 1 2.0|
Hyperplasia, Glandular, Multifocal | 2 | 1 2.0|
Infiltration Cellular, Mononuclear | | |
Cell, Mononuclear Cell, | | |
Multifocal | | 1 3.0|
Inflammation, Chronic, Multifocal | | 1 2.0|
Inflammation, Chronic Active, | | |
Multifocal | 3 2 | 4 3.0|
Inflammation, Multifocal, Subacute | | 2 1.5|
Bilateral, Hyperplasia, Glandular, | | |
Multifocal | 3 | 1 3.0|
Bilateral, Inflammation, Chronic | | |
Active, Multifocal | 2 1 2 2 2 2 2 3 2 2 2 3 2 2 2 2 3 | 27 2.1|
Bilateral, Duct, Ectasia, Focal | | 1 3.0|
Bilateral, Duct, Ectasia, Multifocal | 4 3 3 3 3 3 | 6 3.2|
Duct, Ectasia, Multifocal | 3 | 1 3.0|
Duct, Right, Ectasia, Diffuse | | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic, Multifocal | 2 2 3 3 | 6 2.5|
Inflammation, Chronic, Multifocal, | | |
Suppurative | 4 3| 2 3.5|
Inflammation, Granulomatous, | | |
Multifocal | | 1 3.0|
Inflammation, Multifocal, Subacute | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| |
DAY ON TEST | 1| 2| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 6| |
| 3| 7| 7| 5| 7| 0| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Epithelium, Hyperplasia, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Atrophy, Multifocal | | 1 3.0|
Bilateral, Interstitial Cell, | | |
Hyperplasia, Multifocal | 2| 2 2.0|
Bilateral, Seminiferous Tubule, | | |
Atrophy, Multifocal | 4 4 3 3 4 3 3 4 4 3 4 4 3 3 4 3 | 27 3.4|
Interstitial Cell, Right, | | |
Hyperplasia, Multifocal | 2 2 2 2 2 2 2 | 8 2.0|
Interstitial Cell, Left, Hyperplasia,| | |
Multifocal | 2 2 2 2 | 5 2.2|
Seminiferous Tubule, Atrophy, | | |
Multifocal | | 4 2.8|
Seminiferous Tubule, Right, Atrophy, | | |
Multifocal | 4 4 4 | 5 4.0|
Seminiferous Tubule, Left, Atrophy, | | |
Multifocal | 4 4 2 4 | 6 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + +| 26 |
Neutrophilia | X | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Multifocal, Neutrophil | 3 3| 4 3.0|
Myelofibrosis, Multifocal | 4 | 1 4.0|
Myeloid Cell, Erythroid Cell, | | |
Hypoplasia, Multifocal | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid, Multifocal | | 1 3.0|
Mandibular, Cyst | X X | 3 |
Mandibular, Hemorrhage, Multifocal | 3 3 | 3 3.0|
Mandibular, Hyperplasia, Lymphoid, | | |
Multifocal | 2 3 2 | 6 2.3|
Mandibular, Infiltration Cellular, | | |
Multifocal, Plasma Cell | 3 | 1 3.0|
Mandibular, Inflammation, Chronic, | | |
Multifocal | | 1 2.0|
Mediastinal, Hemorrhage, Multifocal | 3 | 3 2.3|
Mediastinal, Hyperplasia, Lymphoid, | | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| |
DAY ON TEST | 1| 2| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 6| |
| 3| 7| 7| 5| 7| 0| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Inflammation, | | |
Granulomatous, Multifocal | 3 | 1 3.0|
Mediastinal, Inflammation, | | |
Multifocal, Subacute | 3 | 1 3.0|
Mesenteric, Cyst | X | 1 |
Mesenteric, Cyst, Multiple | X | 1 |
Mesenteric, Hemorrhage, Multifocal | 3 | 1 3.0|
Mesenteric, Hyperplasia, Lymphoid, | | |
Multifocal | | 1 2.0|
Mesenteric, Inflammation, Chronic, | | |
Multifocal | | 1 2.0|
Mesenteric, Inflammation, | | |
Granulomatous, Multifocal | | 1 2.0|
Pancreatic, Cyst | | 1 |
Pancreatic, Hemorrhage, Multifocal | | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis, Diffuse, Subacute | | 1 3.0|
Red Pulp, Fibrosis, Chronic, | | |
Multifocal | | 1 3.0|
Red Pulp, Fibrosis, Focal | 3 2 | 2 2.5|
Red Pulp, Fibrosis, Multifocal | 3 2 3| 3 2.7|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Multifocal | 3 | 2 3.0|
Red Pulp, Pigmentation, Hemosiderin, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + I + I I + + + + + + I + + I + + + + M +| 39 |
Depletion Lymphoid, Multifocal | 3 2 3 3 3 3 3 3 3 3 3 2 2 3 3 3| 30 2.7|
Artery, Mediastinum, Inflammation, | | |
Chronic, Multifocal, | | |
Proliferative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M + M M + M M M M + + M + + + M + + M + M M +| 25 |
Acinus, Hyperplasia, Cystic, | | |
Multifocal | 3 2 3 3 3 3 3| 19 2.5|
Acinus, Hyperplasia, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Skin | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inguinal, Ulcer, Chronic Active, | | |
Focal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| |
DAY ON TEST | 1| 2| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 6| |
| 3| 7| 7| 5| 7| 0| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Tail, Hyperkeratosis, Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + I + + + + + + + + + + + + + + + + + + +| 49 |
Femur, Osteopetrosis, Multifocal | 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cerebellum, Hemorrhage, Acute, | | |
Multifocal | | 1 3.0|
Cerebrum, Hemorrhage, Acute, | | |
Multifocal | | 1 3.0|
Cerebrum, Hemorrhage, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous, | | |
Multifocal | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | | 2 3.0|
Bronchiole, Epithelium, Hyperplasia, | | |
Multifocal | | 1 2.0|
Interstitium, Inflammation, Chronic, | | |
Multifocal | 3 2 2 2 2 3 | 6 2.3|
Interstitium, Metaplasia, Focal, | | |
Osseous | 1 | 1 1.0|
Interstitium, Mineralization, | | |
Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + M + +| 45 |
Nasolacrimal Duct, Inflammation, | | |
Chronic, Multifocal | 3 | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Focal, Subacute | 3 | 4 2.3|
Nasolacrimal Duct, Inflammation, | | |
Multifocal | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Multifocal, Subacute | 2 1 2 2 2 3 2 2 3 | 20 2.2|
Respiratory Epithelium, Degeneration,| | |
Multifocal | 3 2 2 1 1 1 3 2 1 | 25 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| |
DAY ON TEST | 1| 2| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 6| |
| 3| 7| 7| 5| 7| 0| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Respiratory Epithelium, Inflammation,| | |
Chronic, Focal | | 1 2.0|
Respiratory Epithelium, Inflammation,| | |
Multifocal, Subacute | 2 2 | 2 2.0|
Respiratory Epithelium, Metaplasia, | | |
Multifocal, Squamous | 3 | 2 2.5|
Submucosa, Olfactory Epithelium, | | |
Inflammation, Multifocal, | | |
Subacute | | 1 2.0|
Submucosa, Respiratory Epithelium, | | |
Inflammation, Acute, Multifocal | | 1 2.0|
Submucosa, Respiratory Epithelium, | | |
Inflammation, Chronic, | | |
Multifocal | 2 2 2 | 4 2.0|
Submucosa, Respiratory Epithelium, | | |
Inflammation, Multifocal | | 1 2.0|
Submucosa, Respiratory Epithelium, | | |
Inflammation, Multifocal, | | |
Subacute | 2 2 2 2 2 2 3 2 2 | 19 2.3|
Submucosa, Respiratory Epithelium, | | |
Inflammation, Multifocal, | | |
Suppurative | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + I | 4 |
Cornea, Inflammation, Multifocal, | | |
Subacute | | 1 2.0|
Lens, Cataract, Multifocal | | 2 3.0|
Retina, Atrophy, Multifocal | | 3 3.3|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 43 |
Hyperplasia, Glandular, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst, Multiple | | 1 |
Bilateral, Nephropathy, Chronic, | | |
Multifocal | 3 2 3 3 3 2 3 4 4 3 4 4 3 4 3 3 2 4 4 4 4 4 3 3 2| 49 3.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| |
DAY ON TEST | 1| 2| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 6| |
| 3| 7| 7| 5| 7| 0| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Cortex, Cyst | X X | 3 |
Cortex, Cyst, Multiple | X | 2 |
Cortex, Cyst, Single | X X X | 4 |
Left, Nephropathy, Chronic, | | |
Multifocal | | 1 2.0|
Papilla, Epithelium, Hyperplasia, | | |
Multifocal | 2 | 1 2.0|
Renal Tubule, Pigmentation, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Mucosa, Hyperplasia, Multifocal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 4| 6| 5| 7| 5| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 2| 2| 8| 7| 6| 9| 2| 6| 1| 2| 2| 1| 2| 3| 2| 2| 2| 2| 1| 2| 0| 2| 2|
| 9| 4| 9| 9| 1| 7| 5| 2| 9| 2| 6| 5| 2| 3| 9| 6| 9| 9| 9| 9| 4| 9| 0| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Large | |
Colon, Mesothelium, Inflammation, | |
Chronic Active, Multifocal | |
Lamina Propria, Rectum, Inflammation,| |
Multifocal, Subacute | |
Rectum, Mesothelium, Inflammation, | |
Chronic Active, Multifocal | |
__________________________________________________________________________|
Intestine Small | |
Necrosis | |
Jejunum, Inflammation, Chronic | |
Active, Multifocal, Proliferative| |
Jejunum, Necrosis | |
Jejunum, Lamina Propria, Metaplasia, | |
Multifocal, Osseous | |
Jejunum, Subserosa, Diverticulum | |
Mucosa, Necrosis | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X X |
Basophilic Focus, Single | X X |
Clear Cell Focus, Multiple | X |
Clear Cell Focus, Single | X |
Eosinophilic Focus, Single | |
Inflammation, Granulomatous, | |
Multifocal | 2 2 1|
Bile Duct, Hyperplasia, Multifocal | 2 2 3 4 3 3 3 3 2 2 3 4 |
Hepatocyte, Cytoplasmic Alteration, | |
Multifocal | |
Hepatocyte, Degeneration, Cystic, | |
Focal | 2 2 2 2 2 |
Hepatocyte, Degeneration, Cystic, | |
Multifocal | 2 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Multifocal | 2 4 3 3 3 |
Left Lateral Lobe, Necrosis, Acute, | |
Focal | 2|
__________________________________________________________________________|
Mesentery | + |
Inflammation, Granulomatous, | |
Multifocal | 3 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Stomach | |
Forestomach, Acanthosis, Focal | |
Forestomach, Hyperkeratosis, Focal | |
Glandular, Necrosis, Acute, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 4| 6| 5| 7| 5| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 2| 2| 8| 7| 6| 9| 2| 6| 1| 2| 2| 1| 2| 3| 2| 2| 2| 2| 1| 2| 0| 2| 2|
| 9| 4| 9| 9| 1| 7| 5| 2| 9| 2| 6| 5| 2| 3| 9| 6| 9| 9| 9| 9| 4| 9| 0| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + |
Atrium Left, Thrombosis, Chronic | X |
Myocardium, Degeneration, Chronic, | |
Multifocal | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + |
Cortex, Degeneration, Fatty, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | |
__________________________________________________________________________|
Parathyroid Gland | + |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + I + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Cyst, Multiple | X |
Pars Distalis, Hyperplasia, Focal | 2 |
Pars Distalis, Karyomegaly, | |
Multifocal | |
Pars Intermedia, Hemorrhage, Chronic,| |
Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Follicle, Cyst, Multiple | X |
C-Cell, Hyperplasia, Focal | 3 2 |
C-Cell, Hyperplasia, Multifocal | 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | |
Head, Granuloma Sperm, Single | |
__________________________________________________________________________|
Preputial Gland | + + + |
__________________________________________________________________________|
Prostate | + + |
Dilatation, Multifocal | 3 |
Inflammation, Chronic Active, | |
Multifocal | 4 |
__________________________________________________________________________|
Seminal Vesicle | + |
Dilatation, Multifocal | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Bilateral, Seminiferous Tubule, | |
Atrophy, Multifocal | 4 4 4 3 3 3 4 3|
Interstitial Cell, Hyperplasia, | |
Multifocal | 2 |
Interstitial Cell, Right, | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 4| 6| 5| 7| 5| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 2| 2| 8| 7| 6| 9| 2| 6| 1| 2| 2| 1| 2| 3| 2| 2| 2| 2| 1| 2| 0| 2| 2|
| 9| 4| 9| 9| 1| 7| 5| 2| 9| 2| 6| 5| 2| 3| 9| 6| 9| 9| 9| 9| 4| 9| 0| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia, Multifocal | 2 3|
Interstitial Cell, Left, Hyperplasia,| |
Multifocal | 2 2 |
Interstitial Tissue, Hemorrhage, | |
Chronic Active, Multifocal | |
Interstitial Tissue, Right, | |
Hemorrhage, Chronic Active, | |
Multifocal | 4 |
Left, Atrophy, Multifocal | 4 |
Seminiferous Tubule, Atrophy, | |
Multifocal | 3 4 4 |
Seminiferous Tubule, Right, Atrophy, | |
Multifocal | 4 4 3 |
Seminiferous Tubule, Left, Atrophy, | |
Multifocal | 4 4 |
Vein, Ectasia, Chronic, Multifocal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + + |
Inguinal, Inflammation, | |
Granulomatous, Multifocal | 3 |
Lumbar, Inflammation, Granulomatous, | |
Multifocal | |
Mediastinal, Inflammation, Chronic, | |
Multifocal | |
Mediastinal, Inflammation, Chronic | |
Active, Multifocal | 4 |
Mediastinal, Pigmentation, | |
Hemosiderin, Multifocal | 3 |
Mesenteric, Hemorrhage, Multifocal | |
Mesenteric, Inflammation, | |
Granulomatous, Multifocal | |
__________________________________________________________________________|
Spleen | + + + + + |
Capsule, Cyst, Multiple | |
Red Pulp, Fibrosis, Chronic, Focal | 2 |
Red Pulp, Fibrosis, Chronic, | |
Multifocal | 3 |
Red Pulp, Fibrosis, Focal | |
Red Pulp, Fibrosis, Multifocal | |
__________________________________________________________________________|
Thymus | + |
Epithelial Cell, Hyperplasia, | |
Multifocal | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 4| 6| 5| 7| 5| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 2| 2| 8| 7| 6| 9| 2| 6| 1| 2| 2| 1| 2| 3| 2| 2| 2| 2| 1| 2| 0| 2| 2|
| 9| 4| 9| 9| 1| 7| 5| 2| 9| 2| 6| 5| 2| 3| 9| 6| 9| 9| 9| 9| 4| 9| 0| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + |
__________________________________________________________________________|
Skin | + + + + + + + + + |
Thoracic, Subcutaneous Tissue, | |
Hemorrhage, Chronic Active, | |
Diffuse | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + |
Cerebellum, Cerebrum, Hemorrhage, | |
Multifocal | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + |
Interstitium, Inflammation, Chronic, | |
Focal | 3 |
Interstitium, Mineralization, | |
Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + M + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Focal, Subacute | |
Nasolacrimal Duct, Inflammation, | |
Multifocal, Subacute | 3 3 2 2 2 2 2 4 2|
Respiratory Epithelium, Degeneration,| |
Multifocal | 3 2 2 2 3 2 3 2 1 3 1 3 3 2 2 3 3 3 2 2 2|
Submucosa, Respiratory Epithelium, | |
Concretion, Multifocal | 3 |
Submucosa, Respiratory Epithelium, | |
Inflammation, Acute, Multifocal | 3 3 |
Submucosa, Respiratory Epithelium, | |
Inflammation, Focal, Subacute | 3 2 |
Submucosa, Respiratory Epithelium, | |
Inflammation, Multifocal, | |
Subacute | 3 3 1 2 2 2 3 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Lens, Cataract, Multifocal | 3 3 |
Retina, Atrophy, Multifocal | 3 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 4| 6| 5| 7| 5| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 2| 2| 8| 7| 6| 9| 2| 6| 1| 2| 2| 1| 2| 3| 2| 2| 2| 2| 1| 2| 0| 2| 2|
| 9| 4| 9| 9| 1| 7| 5| 2| 9| 2| 6| 5| 2| 3| 9| 6| 9| 9| 9| 9| 4| 9| 0| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + |
Congestion, Multifocal | |
Cyst | |
Polycystic Kidney | X |
Bilateral, Nephropathy, Chronic, | |
Multifocal | 3 4 4 4 |
Bilateral, Cortex, Cyst, Multiple | X |
Bilateral, Cortex, Mineralization, | |
Multifocal | |
Bilateral, Pelvis, Hydronephrosis, | |
Multifocal | |
Cortex, Cyst | |
Right, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + |
Inflammation, Acute, Hemorrhagic, | |
Multifocal | 4 |
Mucosa, Hyperplasia, Multifocal | |
Muscularis, Inflammation, Chronic | |
Active, Multifocal | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 6| 6| 4| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 2| 7| 2| 6| 2| 2| 7| 7| 6| 2| 0| 2| 1| 4| 2| 2| 0| 9| 2| 2| 2| 2| 5| 2| 2| |
| 9| 7| 9| 9| 9| 9| 9| 4| 9| 9| 0| 6| 0| 2| 9| 9| 0| 0| 9| 9| 9| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
5000 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large | + | 1 |
Colon, Mesothelium, Inflammation, | | |
Chronic Active, Multifocal | 3 | 1 3.0|
Lamina Propria, Rectum, Inflammation,| | |
Multifocal, Subacute | 3 | 1 3.0|
Rectum, Mesothelium, Inflammation, | | |
Chronic Active, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small | + | 1 |
Necrosis | X | 1 |
Jejunum, Inflammation, Chronic | | |
Active, Multifocal, Proliferative| 4 | 1 4.0|
Jejunum, Necrosis | X | 1 |
Jejunum, Lamina Propria, Metaplasia, | | |
Multifocal, Osseous | 4 | 1 4.0|
Jejunum, Subserosa, Diverticulum | X | 1 |
Mucosa, Necrosis | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus, Multiple | X X X X X X X X | 12 |
Basophilic Focus, Single | | 2 |
Clear Cell Focus, Multiple | | 1 |
Clear Cell Focus, Single | | 1 |
Eosinophilic Focus, Single | X | 1 |
Inflammation, Granulomatous, | | |
Multifocal | 2 2 3 3| 7 2.1|
Bile Duct, Hyperplasia, Multifocal | 3 3 3 3 3 2 2 3 2 2 3 4 3 2 2 3 3 2| 30 2.7|
Hepatocyte, Cytoplasmic Alteration, | | |
Multifocal | 2 2 | 2 2.0|
Hepatocyte, Degeneration, Cystic, | | |
Focal | 2 2 | 7 2.0|
Hepatocyte, Degeneration, Cystic, | | |
Multifocal | 1 3 3 2| 5 2.2|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Multifocal | 3 3 2 | 8 2.9|
Left Lateral Lobe, Necrosis, Acute, | | |
Focal | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Inflammation, Granulomatous, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 6| 6| 4| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 2| 7| 2| 6| 2| 2| 7| 7| 6| 2| 0| 2| 1| 4| 2| 2| 0| 9| 2| 2| 2| 2| 5| 2| 2| |
| 9| 7| 9| 9| 9| 9| 9| 4| 9| 9| 0| 6| 0| 2| 9| 9| 0| 0| 9| 9| 9| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
5000 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + | 2 |
Forestomach, Acanthosis, Focal | 2 | 1 2.0|
Forestomach, Hyperkeratosis, Focal | 2 | 1 2.0|
Glandular, Necrosis, Acute, | | |
Multifocal | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 2 |
Atrium Left, Thrombosis, Chronic | | 1 |
Myocardium, Degeneration, Chronic, | | |
Multifocal | | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + | 3 |
Cortex, Degeneration, Fatty, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + I + + + + + + + + + + + + + +| 44 |
Pars Distalis, Cyst | X X | 4 |
Pars Distalis, Cyst, Multiple | | 1 |
Pars Distalis, Hyperplasia, Focal | 3 2 2 3 3 3| 7 2.6|
Pars Distalis, Karyomegaly, | | |
Multifocal | 2 | 1 2.0|
Pars Intermedia, Hemorrhage, Chronic,| | |
Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Bilateral, Follicle, Cyst, Multiple | | 1 |
C-Cell, Hyperplasia, Focal | 3 2 | 4 2.5|
C-Cell, Hyperplasia, Multifocal | 2 2 | 5 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + | 1 |
Head, Granuloma Sperm, Single | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | | 3 |
__________________________________________________________________________|____________|
Prostate | + | 3 |
Dilatation, Multifocal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 6| 6| 4| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 2| 7| 2| 6| 2| 2| 7| 7| 6| 2| 0| 2| 1| 4| 2| 2| 0| 9| 2| 2| 2| 2| 5| 2| 2| |
| 9| 7| 9| 9| 9| 9| 9| 4| 9| 9| 0| 6| 0| 2| 9| 9| 0| 0| 9| 9| 9| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
5000 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active, | | |
Multifocal | 2 | 2 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
Dilatation, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + +| 38 |
Bilateral, Seminiferous Tubule, | | |
Atrophy, Multifocal | 4 4 4 3 3 3 3 4 4 4 4 3 | 20 3.6|
Interstitial Cell, Hyperplasia, | | |
Multifocal | 2 2 2 | 4 2.0|
Interstitial Cell, Right, | | |
Hyperplasia, Multifocal | 2 | 3 2.3|
Interstitial Cell, Left, Hyperplasia,| | |
Multifocal | 2 2 | 4 2.0|
Interstitial Tissue, Hemorrhage, | | |
Chronic Active, Multifocal | 3 | 1 3.0|
Interstitial Tissue, Right, | | |
Hemorrhage, Chronic Active, | | |
Multifocal | | 1 4.0|
Left, Atrophy, Multifocal | | 1 4.0|
Seminiferous Tubule, Atrophy, | | |
Multifocal | 3 | 4 3.5|
Seminiferous Tubule, Right, Atrophy, | | |
Multifocal | 4 | 4 3.8|
Seminiferous Tubule, Left, Atrophy, | | |
Multifocal | 4 | 3 4.0|
Vein, Ectasia, Chronic, Multifocal | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 9 |
Inguinal, Inflammation, | | |
Granulomatous, Multifocal | | 1 3.0|
Lumbar, Inflammation, Granulomatous, | | |
Multifocal | 3 | 1 3.0|
Mediastinal, Inflammation, Chronic, | | |
Multifocal | 3 | 1 3.0|
Mediastinal, Inflammation, Chronic | | |
Active, Multifocal | | 1 4.0|
Mediastinal, Pigmentation, | | |
Hemosiderin, Multifocal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 6| 6| 4| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 2| 7| 2| 6| 2| 2| 7| 7| 6| 2| 0| 2| 1| 4| 2| 2| 0| 9| 2| 2| 2| 2| 5| 2| 2| |
| 9| 7| 9| 9| 9| 9| 9| 4| 9| 9| 0| 6| 0| 2| 9| 9| 0| 0| 9| 9| 9| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
5000 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mesenteric, Hemorrhage, Multifocal | 3 | 1 3.0|
Mesenteric, Inflammation, | | |
Granulomatous, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 14 |
Capsule, Cyst, Multiple | X | 1 |
Red Pulp, Fibrosis, Chronic, Focal | | 1 2.0|
Red Pulp, Fibrosis, Chronic, | | |
Multifocal | | 1 3.0|
Red Pulp, Fibrosis, Focal | 2 | 1 2.0|
Red Pulp, Fibrosis, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | | 1 |
Epithelial Cell, Hyperplasia, | | |
Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 4 |
__________________________________________________________________________|____________|
Skin | + + + | 12 |
Thoracic, Subcutaneous Tissue, | | |
Hemorrhage, Chronic Active, | | |
Diffuse | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 1 |
Cerebellum, Cerebrum, Hemorrhage, | | |
Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + | 3 |
Interstitium, Inflammation, Chronic, | | |
Focal | | 1 3.0|
Interstitium, Mineralization, | | |
Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Nasolacrimal Duct, Inflammation, | | |
Focal, Subacute | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 6| 6| 4| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 2| 7| 2| 6| 2| 2| 7| 7| 6| 2| 0| 2| 1| 4| 2| 2| 0| 9| 2| 2| 2| 2| 5| 2| 2| |
| 9| 7| 9| 9| 9| 9| 9| 4| 9| 9| 0| 6| 0| 2| 9| 9| 0| 0| 9| 9| 9| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
5000 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Multifocal, Subacute | 3 3 2 2 2 2 2 2 2 2| 19 2.3|
Respiratory Epithelium, Degeneration,| | |
Multifocal | 3 3 3 2 2 2 2 3 3 3 2 1 2 3 2 3 3| 38 2.4|
Submucosa, Respiratory Epithelium, | | |
Concretion, Multifocal | | 1 3.0|
Submucosa, Respiratory Epithelium, | | |
Inflammation, Acute, Multifocal | 2 | 3 2.7|
Submucosa, Respiratory Epithelium, | | |
Inflammation, Focal, Subacute | | 2 2.5|
Submucosa, Respiratory Epithelium, | | |
Inflammation, Multifocal, | | |
Subacute | 2 2 2 2 3 2 2 2 | 23 2.1|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
Lens, Cataract, Multifocal | | 2 3.0|
Retina, Atrophy, Multifocal | | 2 3.5|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 8 |
Congestion, Multifocal | 4 | 1 4.0|
Cyst | X | 1 |
Polycystic Kidney | | 1 |
Bilateral, Nephropathy, Chronic, | | |
Multifocal | 4 4 | 6 3.8|
Bilateral, Cortex, Cyst, Multiple | | 1 |
Bilateral, Cortex, Mineralization, | | |
Multifocal | 3 | 1 3.0|
Bilateral, Pelvis, Hydronephrosis, | | |
Multifocal | 4 | 1 4.0|
Cortex, Cyst | X | 1 |
Right, Cyst | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 2 |
Inflammation, Acute, Hemorrhagic, | | |
Multifocal | | 1 4.0|
Mucosa, Hyperplasia, Multifocal | 3 | 1 3.0|
Muscularis, Inflammation, Chronic | | |
Active, Multifocal | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 6| 6|
DAY ON TEST | 2| 2| 2| 6| 2| 2| 8| 2| 3| 9| 2| 2| 2| 2| 2| 2| 2| 8| 2| 9| 5| 8| 2| 7| 5|
| 7| 7| 7| 5| 7| 7| 1| 7| 1| 3| 7| 7| 7| 7| 7| 7| 7| 0| 5| 7| 9| 1| 7| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10000 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Submucosa, Inflammation, Chronic, | |
Multifocal | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + A + + + + + + + + + + + + + A + + + +|
Colon, Peyer's Patch, Hyperplasia, | |
Lymphoid, Multifocal | 3 |
Peyer's Patch, Rectum, Hyperplasia, | |
Lymphoid, Multifocal | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Basophilic Focus, Multiple | X X X X |
Basophilic Focus, Single | X |
Clear Cell Focus, Focal | |
Clear Cell Focus, Multiple | X X X |
Clear Cell Focus, Single | |
Eosinophilic Focus | |
Eosinophilic Focus, Multiple | X |
Eosinophilic Focus, Single | X |
Inflammation, Granulomatous, | |
Multifocal | 1 |
Bile Duct, Hyperplasia, Cystic, | |
Multifocal | |
Bile Duct, Hyperplasia, Multifocal | 2 3 2 4 2 2 3 3 2 2 4|
Capsule, Hematocyst, Single | |
Centrilobular, Necrosis, Acute, | |
Multifocal | 3 |
Hepatocyte, Cytoplasmic Alteration, | |
Focal | 2 |
Hepatocyte, Degeneration, Cystic, | |
Focal | 2 2|
Hepatocyte, Degeneration, Cystic, | |
Multifocal | 2 |
Hepatocyte, Necrosis, Acute, | |
Multifocal | 2 1 |
Hepatocyte, Necrosis, Focal | 3 |
Hepatocyte, Necrosis, Multifocal | 2 |
Hepatocyte, Vacuolization | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 6| 6|
DAY ON TEST | 2| 2| 2| 6| 2| 2| 8| 2| 3| 9| 2| 2| 2| 2| 2| 2| 2| 8| 2| 9| 5| 8| 2| 7| 5|
| 7| 7| 7| 5| 7| 7| 1| 7| 1| 3| 7| 7| 7| 7| 7| 7| 7| 0| 5| 7| 9| 1| 7| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10000 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Cytoplasmic, Focal | 2 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Multifocal | 1 2 4 2 |
Median Lobe, Hepatocyte, | |
Degeneration, Fatty, Multifocal | |
__________________________________________________________________________|
Mesentery | + |
Necrosis, Chronic, Focal | |
Fat, Necrosis | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 1 2 |
Acinus, Atrophy, Multifocal | 3 2 2 2 1 1 2 3 2 |
Acinus, Cytoplasmic Alteration, | |
Multifocal | |
Artery, Inflammation, Chronic Active,| |
Multifocal | 4 |
Duct, Ectasia, Multifocal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Muscularis, | |
Inflammation, Chronic, Multifocal| 3 |
Glandular, Inflammation, Chronic, | |
Multifocal | 2 |
Glandular, Necrosis, Acute, | |
Multifocal | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium Left, Thrombosis | X |
Atrium Left, Thrombosis, Multiple, | |
Subacute | X |
Myocardium, Degeneration, Chronic, | |
Multifocal | 2 3 3 2 3 2 3 3 3 3 3 2 3 2 2 3 2 3 3 3 2 |
Myocardium, Degeneration, Multifocal | 2 |
Myocardium, Mineralization, | |
Multifocal | 2 |
Ventricle Left, Thrombosis, Multiple | X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Cortex, Hematopoietic | |
Cell Proliferation, Multifocal | |
Bilateral, Cortex, Vacuolization | |
Cytoplasmic, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 6| 6|
DAY ON TEST | 2| 2| 2| 6| 2| 2| 8| 2| 3| 9| 2| 2| 2| 2| 2| 2| 2| 8| 2| 9| 5| 8| 2| 7| 5|
| 7| 7| 7| 5| 7| 7| 1| 7| 1| 3| 7| 7| 7| 7| 7| 7| 7| 0| 5| 7| 9| 1| 7| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10000 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cortex, Congestion, Multifocal | |
Cortex, Cytoplasmic Alteration, Focal| 3 |
Cortex, Degeneration, Fatty, Focal | 2 2 2 2 |
Cortex, Degeneration, Fatty, | |
Multifocal | 2 |
Cortex, Hyperplasia, Focal | 2 2 3 |
Cortex, Hyperplasia, Multifocal | |
Cortex, Karyomegaly, Focal | |
Cortex, Necrosis, Multifocal | 2 |
Medulla, Hyperplasia, Focal | 2 2 2 |
Medulla, Hyperplasia, Multifocal | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + M + M + +|
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Pars Distalis, Cyst, Multiple | |
Pars Distalis, Hemorrhage, Focal | 4 |
Pars Distalis, Hyperplasia, Focal | 3 3 |
Pars Distalis, Hyperplasia, | |
Multifocal | 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 1 2 2 |
C-Cell, Hyperplasia, Multifocal | 2 |
Follicle, Cyst | X X |
Follicle, Cyst, Multiple | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Inflammation, Chronic, | |
Multifocal | |
Bilateral, Inflammation, Multifocal, | |
Subacute | |
__________________________________________________________________________|
Penis | + |
Inflammation, Acute, Multifocal, | |
Necrotizing | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Multifocal, Nodular, | |
Squamous | 3 |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 6| 6|
DAY ON TEST | 2| 2| 2| 6| 2| 2| 8| 2| 3| 9| 2| 2| 2| 2| 2| 2| 2| 8| 2| 9| 5| 8| 2| 7| 5|
| 7| 7| 7| 5| 7| 7| 1| 7| 1| 3| 7| 7| 7| 7| 7| 7| 7| 0| 5| 7| 9| 1| 7| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10000 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic Active, | |
Multifocal | 3 3 |
Inflammation, Chronic Active, | |
Multifocal, Necrotizing | 4 |
Bilateral, Inflammation, Chronic | |
Active, Multifocal | 2 2 2 2 3 2 4 2 3 2 2 3 2 3 2 2 2 2 2|
Bilateral, Duct, Ectasia, Focal | 3 |
Bilateral, Duct, Ectasia, Multifocal | 2 |
Duct, Ectasia, Focal | 3 3|
Duct, Ectasia, Multifocal | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Multifocal | 2 2 |
Inflammation, Chronic Active, | |
Multifocal | 3 3|
Inflammation, Focal, Subacute | 2 |
Inflammation, Multifocal, Subacute | |
Serosa, Inflammation, Chronic, | |
Multifocal | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Multifocal | 4 |
Bilateral, Interstitial Cell, | |
Hyperplasia, Multifocal | 2 2 |
Bilateral, Seminiferous Tubule, | |
Atrophy, Chronic, Multifocal | |
Bilateral, Seminiferous Tubule, | |
Atrophy, Multifocal | 4 4 4 4 4 4 4 3 |
Interstitial Cell, Hyperplasia, | |
Multifocal | |
Interstitial Cell, Right, | |
Hyperplasia, Multifocal | 2 |
Interstitial Cell, Left, Hyperplasia,| |
Focal | 3 |
Interstitial Cell, Left, Hyperplasia,| |
Multifocal | 2 |
Seminiferous Tubule, Atrophy, | |
Multifocal | 3 3 3 |
Seminiferous Tubule, Right, Atrophy, | |
Multifocal | 4 |
Seminiferous Tubule, Left, Atrophy, | |
Multifocal | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 6| 6|
DAY ON TEST | 2| 2| 2| 6| 2| 2| 8| 2| 3| 9| 2| 2| 2| 2| 2| 2| 2| 8| 2| 9| 5| 8| 2| 7| 5|
| 7| 7| 7| 5| 7| 7| 1| 7| 1| 3| 7| 7| 7| 7| 7| 7| 7| 0| 5| 7| 9| 1| 7| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10000 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Multifocal, Neutrophil | |
Myeloid Cell, Erythroid Cell, | |
Hypoplasia, Diffuse | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid, Multifocal | 3 |
Mandibular, Cyst | |
Mandibular, Depletion Lymphoid, | |
Multifocal | |
Mandibular, Hemorrhage, Multifocal | 2 2 |
Mandibular, Hyperplasia, Lymphoid, | |
Multifocal | 2 2 2 3 |
Mandibular, Hyperplasia, Multifocal, | |
Plasma Cell | 3 3 |
Mandibular, Infiltration Cellular, | |
Multifocal, Plasma Cell | 3 |
Mandibular, Inflammation, Chronic, | |
Multifocal | 3 |
Mandibular, Inflammation, | |
Granulomatous, Multifocal | 2 |
Mediastinal, Hemorrhage, Multifocal | 2 |
Mediastinal, Inflammation, | |
Granulomatous, Multifocal | 2 2 |
Mesenteric, Cyst, Multiple | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Follicle, Necrosis, Acute, | |
Multifocal | |
Red Pulp, Fibrosis, Multifocal | |
Red Pulp, Hematopoietic Cell | |
Proliferation, Multifocal | 3 4 2 |
Red Pulp, Pigmentation, Hemosiderin, | |
Multifocal | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + I + + + + + + + + + M + + + + + I|
Depletion Lymphoid, Multifocal | 3 3 3 3 2 3 3 3 2 2 3 2 4 3 3 3 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M + M M + + M + M + + + M + M + M M M M M M|
Acinus, Hyperplasia, Cystic, | |
Multifocal | 2 2 2 2 3 |
Acinus, Hyperplasia, Multifocal | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abdominal, Inflammation, Chronic, | |
Focal, Suppurative | 4 |
Abdominal, Subcutaneous Tissue, | |
Edema, Multifocal, Subacute | 3 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 6| 6|
DAY ON TEST | 2| 2| 2| 6| 2| 2| 8| 2| 3| 9| 2| 2| 2| 2| 2| 2| 2| 8| 2| 9| 5| 8| 2| 7| 5|
| 7| 7| 7| 5| 7| 7| 1| 7| 1| 3| 7| 7| 7| 7| 7| 7| 7| 0| 5| 7| 9| 1| 7| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10000 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inguinal, Abscess | X |
Inguinal, Subcutaneous Tissue, | |
Inflammation, Chronic Active, | |
Multifocal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + M + + + +|
Femur, Osteopetrosis, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Medulla, Cerebrum, Hemorrhage, Acute,| |
Multifocal | |
Third Ventricle, Hemorrhage, Focal | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Acute, Diffuse | 3 |
Inflammation, Granulomatous, | |
Multifocal | 3 |
Interstitium, Inflammation, Acute, | |
Focal | 2 2 |
Interstitium, Inflammation, Chronic, | |
Multifocal | 2 |
Interstitium, Inflammation, | |
Multifocal, Subacute | |
Mediastinum, Inflammation, | |
Granulomatous, Multifocal | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + M + + + + +|
Degeneration, Multifocal | |
Nasolacrimal Duct, Inflammation, | |
Focal, Subacute | 2 |
Nasolacrimal Duct, Inflammation, | |
Multifocal, Subacute | 2 2 2 2 2 2 |
Respiratory Epithelium, Degeneration,| |
Multifocal | 2 3 3 3 3 3 2 3 3 2 2 2 2 2 3 3 3 3 3 3 3 3 3 1|
Submucosa, Respiratory Epithelium, | |
Inflammation, Acute, Focal | |
Submucosa, Respiratory Epithelium, | |
Inflammation, Acute, Multifocal | 2 |
Submucosa, Respiratory Epithelium, | |
Inflammation, Chronic, | |
Multifocal, Suppurative | |
Submucosa, Respiratory Epithelium, | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 6| 6| 7| 6| 6|
DAY ON TEST | 2| 2| 2| 6| 2| 2| 8| 2| 3| 9| 2| 2| 2| 2| 2| 2| 2| 8| 2| 9| 5| 8| 2| 7| 5|
| 7| 7| 7| 5| 7| 7| 1| 7| 1| 3| 7| 7| 7| 7| 7| 7| 7| 0| 5| 7| 9| 1| 7| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10000 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Focal, Subacute | 1 |
Submucosa, Respiratory Epithelium, | |
Inflammation, Multifocal, | |
Subacute | 4 3 3 2 2 2 3 3 2 |
Submucosa, Respiratory Epithelium, | |
Inflammation, Multifocal, | |
Suppurative | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | |
Retina, Atrophy, Multifocal | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Focal, Glandular | |
Inflammation, Granulomatous, | |
Multifocal | 3 |
Inflammation, Multifocal, Subacute | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Nephropathy, Chronic, | |
Multifocal | 4 2 2 2 3 3 3 3 2 1 3 3 2 3 3 3 4 2 2 3 2 3 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 4| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 4| 2| 5| 1| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| |
| 7| 7| 7| 7| 7| 7| 7| 9| 5| 7| 4| 1| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 9| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
10000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Submucosa, Inflammation, Chronic, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + A + + + + + + + + + + +| 47 |
Colon, Peyer's Patch, Hyperplasia, | | |
Lymphoid, Multifocal | 3 3| 3 3.0|
Peyer's Patch, Rectum, Hyperplasia, | | |
Lymphoid, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + M + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + M + + + + + A + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 3 |
Basophilic Focus, Multiple | X X X X X X X| 11 |
Basophilic Focus, Single | | 1 |
Clear Cell Focus, Focal | X | 1 |
Clear Cell Focus, Multiple | X | 4 |
Clear Cell Focus, Single | X X X| 3 |
Eosinophilic Focus | X X| 2 |
Eosinophilic Focus, Multiple | X X | 3 |
Eosinophilic Focus, Single | | 1 |
Inflammation, Granulomatous, | | |
Multifocal | 2 | 2 1.5|
Bile Duct, Hyperplasia, Cystic, | | |
Multifocal | 2| 1 2.0|
Bile Duct, Hyperplasia, Multifocal | 3 3 4 2 2 2 2 2 2 3 2 2 | 23 2.5|
Capsule, Hematocyst, Single | X | 1 |
Centrilobular, Necrosis, Acute, | | |
Multifocal | | 1 3.0|
Hepatocyte, Cytoplasmic Alteration, | | |
Focal | 2 | 2 2.0|
Hepatocyte, Degeneration, Cystic, | | |
Focal | 2 2 3 2 | 6 2.2|
Hepatocyte, Degeneration, Cystic, | | |
Multifocal | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 4| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 4| 2| 5| 1| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| |
| 7| 7| 7| 7| 7| 7| 7| 9| 5| 7| 4| 1| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 9| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
10000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hepatocyte, Necrosis, Acute, | | |
Multifocal | | 2 1.5|
Hepatocyte, Necrosis, Focal | | 1 3.0|
Hepatocyte, Necrosis, Multifocal | | 1 2.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | | 1 2.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Multifocal | 3 3 3 3 4 2 | 10 2.7|
Median Lobe, Hepatocyte, | | |
Degeneration, Fatty, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Necrosis, Chronic, Focal | X | 1 |
Fat, Necrosis | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy, Focal | 2 1 2 2 2 | 7 1.7|
Acinus, Atrophy, Multifocal | 2 2 2 2 2 1 3 | 16 2.0|
Acinus, Cytoplasmic Alteration, | | |
Multifocal | 2 | 1 2.0|
Artery, Inflammation, Chronic Active,| | |
Multifocal | | 1 4.0|
Duct, Ectasia, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Forestomach, Muscularis, | | |
Inflammation, Chronic, Multifocal| | 1 3.0|
Glandular, Inflammation, Chronic, | | |
Multifocal | | 1 2.0|
Glandular, Necrosis, Acute, | | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium Left, Thrombosis | | 1 |
Atrium Left, Thrombosis, Multiple, | | |
Subacute | | 1 |
Myocardium, Degeneration, Chronic, | | |
Multifocal | 2 3 3 3 3 3 4 2 3 2 2 3 3 3 3 3 2 3 2 3 2 3 3| 44 2.7|
Myocardium, Degeneration, Multifocal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 4| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 4| 2| 5| 1| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| |
| 7| 7| 7| 7| 7| 7| 7| 9| 5| 7| 4| 1| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 9| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
10000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Myocardium, Mineralization, | | |
Multifocal | | 1 2.0|
Ventricle Left, Thrombosis, Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Cortex, Hematopoietic | | |
Cell Proliferation, Multifocal | 2 | 1 2.0|
Bilateral, Cortex, Vacuolization | | |
Cytoplasmic, Multifocal | | 1 3.0|
Cortex, Congestion, Multifocal | 2 | 1 2.0|
Cortex, Cytoplasmic Alteration, Focal| 2 | 2 2.5|
Cortex, Degeneration, Fatty, Focal | 2 3 | 6 2.2|
Cortex, Degeneration, Fatty, | | |
Multifocal | | 1 2.0|
Cortex, Hyperplasia, Focal | 2 2 | 5 2.2|
Cortex, Hyperplasia, Multifocal | 2 | 1 2.0|
Cortex, Karyomegaly, Focal | 3 | 1 3.0|
Cortex, Necrosis, Multifocal | | 1 2.0|
Medulla, Hyperplasia, Focal | 2 2 2 2 3 2 2 | 10 2.1|
Medulla, Hyperplasia, Multifocal | 3 | 3 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + +| 22 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + M + + + + + + + + + M + + + +| 44 |
Hyperplasia, Multifocal | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Cyst, Multiple | X | 1 |
Pars Distalis, Hemorrhage, Focal | | 1 4.0|
Pars Distalis, Hyperplasia, Focal | 2 2 3 | 5 2.6|
Pars Distalis, Hyperplasia, | | |
Multifocal | 3 | 5 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 2 2 2 | 6 1.8|
C-Cell, Hyperplasia, Multifocal | 2 2 | 3 2.0|
Follicle, Cyst | X X X | 5 |
Follicle, Cyst, Multiple | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 4| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 4| 2| 5| 1| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| |
| 7| 7| 7| 7| 7| 7| 7| 9| 5| 7| 4| 1| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 9| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
10000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Inflammation, Chronic, | | |
Multifocal | 3 | 1 3.0|
Bilateral, Inflammation, Multifocal, | | |
Subacute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Penis | | 1 |
Inflammation, Acute, Multifocal, | | |
Necrotizing | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + M + + + + + M + + + + + + + + M + +| 47 |
Hyperplasia, Multifocal, Nodular, | | |
Squamous | | 1 3.0|
Inflammation, Chronic Active, | | |
Multifocal | 2 | 3 2.7|
Inflammation, Chronic Active, | | |
Multifocal, Necrotizing | | 1 4.0|
Bilateral, Inflammation, Chronic | | |
Active, Multifocal | 2 2 2 2 3 3 2 3 3 3 2 3 2 2 2 2 2| 36 2.3|
Bilateral, Duct, Ectasia, Focal | | 1 3.0|
Bilateral, Duct, Ectasia, Multifocal | 3 | 2 2.5|
Duct, Ectasia, Focal | 3 | 3 3.0|
Duct, Ectasia, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Multifocal | 3 | 3 2.3|
Inflammation, Chronic Active, | | |
Multifocal | | 2 3.0|
Inflammation, Focal, Subacute | | 1 2.0|
Inflammation, Multifocal, Subacute | 2 2 2 | 3 2.0|
Serosa, Inflammation, Chronic, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Multifocal | | 1 4.0|
Bilateral, Interstitial Cell, | | |
Hyperplasia, Multifocal | 2 2 | 4 2.0|
Bilateral, Seminiferous Tubule, | | |
Atrophy, Chronic, Multifocal | 4| 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 4| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 4| 2| 5| 1| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| |
| 7| 7| 7| 7| 7| 7| 7| 9| 5| 7| 4| 1| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 9| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
10000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Bilateral, Seminiferous Tubule, | | |
Atrophy, Multifocal | 3 4 3 4 4 4 3 4 3 4 4 4 | 20 3.8|
Interstitial Cell, Hyperplasia, | | |
Multifocal | 2 2 | 2 2.0|
Interstitial Cell, Right, | | |
Hyperplasia, Multifocal | 2 2 | 3 2.0|
Interstitial Cell, Left, Hyperplasia,| | |
Focal | | 1 3.0|
Interstitial Cell, Left, Hyperplasia,| | |
Multifocal | 2 | 2 2.0|
Seminiferous Tubule, Atrophy, | | |
Multifocal | | 3 3.0|
Seminiferous Tubule, Right, Atrophy, | | |
Multifocal | 4 4 | 3 4.0|
Seminiferous Tubule, Left, Atrophy, | | |
Multifocal | 4 4 4 | 4 3.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Multifocal, Neutrophil | 2 | 1 2.0|
Myeloid Cell, Erythroid Cell, | | |
Hypoplasia, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Lymphoid, Multifocal | | 1 3.0|
Mandibular, Cyst | X | 1 |
Mandibular, Depletion Lymphoid, | | |
Multifocal | 2 | 1 2.0|
Mandibular, Hemorrhage, Multifocal | 3 2 2 | 5 2.2|
Mandibular, Hyperplasia, Lymphoid, | | |
Multifocal | 3 | 5 2.4|
Mandibular, Hyperplasia, Multifocal, | | |
Plasma Cell | 3 3 3| 5 3.0|
Mandibular, Infiltration Cellular, | | |
Multifocal, Plasma Cell | | 1 3.0|
Mandibular, Inflammation, Chronic, | | |
Multifocal | | 1 3.0|
Mandibular, Inflammation, | | |
Granulomatous, Multifocal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 4| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 4| 2| 5| 1| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| |
| 7| 7| 7| 7| 7| 7| 7| 9| 5| 7| 4| 1| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 9| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
10000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Hemorrhage, Multifocal | 3 2 2 | 4 2.3|
Mediastinal, Inflammation, | | |
Granulomatous, Multifocal | 2 | 3 2.0|
Mesenteric, Cyst, Multiple | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoid Follicle, Necrosis, Acute, | | |
Multifocal | 2 | 1 2.0|
Red Pulp, Fibrosis, Multifocal | 1 | 1 1.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation, Multifocal | 3 3 | 5 3.0|
Red Pulp, Pigmentation, Hemosiderin, | | |
Multifocal | 3 | 2 3.5|
__________________________________________________________________________|____________|
Thymus | + + + + M + I M + + + + + M + + + + + + + + + + +| 43 |
Depletion Lymphoid, Multifocal | 2 2 2 2 2 2 3 2 3 2 3 3 3 2 2| 33 2.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + M + M M M M + M + + M + + + M M + M M M +| 22 |
Acinus, Hyperplasia, Cystic, | | |
Multifocal | 2 2 3 3 3 3 3 | 12 2.5|
Acinus, Hyperplasia, Multifocal | 2 2| 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abdominal, Inflammation, Chronic, | | |
Focal, Suppurative | | 1 4.0|
Abdominal, Subcutaneous Tissue, | | |
Edema, Multifocal, Subacute | | 1 3.0|
Inguinal, Abscess | | 1 |
Inguinal, Subcutaneous Tissue, | | |
Inflammation, Chronic Active, | | |
Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Femur, Osteopetrosis, Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Medulla, Cerebrum, Hemorrhage, Acute,| | |
Multifocal | 2 | 1 2.0|
Third Ventricle, Hemorrhage, Focal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 4| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 4| 2| 5| 1| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| |
| 7| 7| 7| 7| 7| 7| 7| 9| 5| 7| 4| 1| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 9| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
10000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion, Acute, Diffuse | | 1 3.0|
Inflammation, Granulomatous, | | |
Multifocal | | 1 3.0|
Interstitium, Inflammation, Acute, | | |
Focal | | 2 2.0|
Interstitium, Inflammation, Chronic, | | |
Multifocal | | 1 2.0|
Interstitium, Inflammation, | | |
Multifocal, Subacute | 2 | 1 2.0|
Mediastinum, Inflammation, | | |
Granulomatous, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + M + + + + + M + + + + + + + + M + +| 46 |
Degeneration, Multifocal | 3 | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Focal, Subacute | 2 2 3 2 3 | 6 2.3|
Nasolacrimal Duct, Inflammation, | | |
Multifocal, Subacute | 2 2 2 2 2 | 11 2.0|
Respiratory Epithelium, Degeneration,| | |
Multifocal | 2 3 3 2 3 3 3 3 2 3 3 3 3 3 1 3 2 2 | 42 2.6|
Submucosa, Respiratory Epithelium, | | |
Inflammation, Acute, Focal | 2 | 1 2.0|
Submucosa, Respiratory Epithelium, | | |
Inflammation, Acute, Multifocal | | 1 2.0|
Submucosa, Respiratory Epithelium, | | |
Inflammation, Chronic, | | |
Multifocal, Suppurative | 3 | 1 3.0|
Submucosa, Respiratory Epithelium, | | |
Inflammation, Focal, Subacute | | 1 1.0|
Submucosa, Respiratory Epithelium, | | |
Inflammation, Multifocal, | | |
Subacute | 2 3 3 2 2 2 2 2 2 2 3 2 2| 22 2.4|
Submucosa, Respiratory Epithelium, | | |
Inflammation, Multifocal, | | |
Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05052-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DICHLOROPHENOL Date: 05/05/97
Route: DOSED FEED Time: 11:10:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 4| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 4| 2| 5| 1| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| |
| 7| 7| 7| 7| 7| 7| 7| 9| 5| 7| 4| 1| 7| 7| 7| 0| 7| 3| 7| 7| 7| 7| 9| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
10000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Lens, Cataract | 2 | 1 2.0|
Retina, Atrophy, Multifocal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + | 36 |
Hyperplasia, Focal, Glandular | 2 | 1 2.0|
Inflammation, Granulomatous, | | |
Multifocal | | 1 3.0|
Inflammation, Multifocal, Subacute | 2 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
Bilateral, Nephropathy, Chronic, | | |
Multifocal | 3 3 2 3 3 4 4 1 3 3 4 2 3 1 3 3 3 2 3 3 4 1 3 3| 48 2.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mucosa, Hyperplasia, Multifocal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
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