TDMS Study 05052-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/07/94
EXP: 05052 2,4-DICHLOROPHENOL TIME: 20:46:29
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: C55345
CONT: N01-ES-38068 CAS: 120-83-2
PATHOLOGIST: S. ESUTIS R. PERSING
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/07/94
EXP: 05052 2,4-DICHLOROPHENOL TIME: 20:46:29
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: C55345
CONT: N01-ES-38068 CAS: 120-83-2
PATHOLOGIST: S. ESUTIS R. PERSING
2,4-DICHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 727 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 419 498 548 571 622 652 656 658 663 665 |
| 671 671 674 680 680 695 713 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 25 CENSORED DEATHS 0 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 414 426 469 477 516 559 562 577 592 622 |
| 625 636 642 665 669 674 674 679 681 690 |
| 700 700 700 710 713 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 219 454 519 597 611 623 625 631 645 658 |
| 659 665 674 680 681 681 693 700 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
2,4-DICHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 727 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 727 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 98.0 98.0 96.0 92.0 80.0 66.0 |
| | |
| | |
|5000 PPM | 100.0 100.0 100.0 100.0 98.0 92.0 90.0 82.0 72.0 50.0 |
| | |
| | |
|10000 PPM| 100.0 100.0 98.0 98.0 98.0 96.0 94.0 92.0 76.0 64.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 5000 PPM 10000 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 66.0% 50.0% 64.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.877 P=0.148 P=0.939 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 631.5 614.9 611.9 |
|NATURAL DEATHS (C) | (19.0) (18.4) (27.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 694.5 670.9 685.6 |
|(STANDARD ERROR) | ( 9.0) (12.1) (12.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
2,4-DICHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 289 429 560 580 610 636 659 692 693 693 |
| 693 695 701 708 713 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2500 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 7 CENSORED DEATHS 0 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 188 562 584 610 647 674 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 343 343 426 464 548 571 638 671 674 713 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
2,4-DICHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 728 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 728 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 98.0 98.0 96.0 96.0 92.0 86.0 68.0 |
| | |
| | |
|2500 PPM | 100.0 100.0 98.0 98.0 98.0 98.0 98.0 94.0 90.0 86.0 |
| | |
| | |
|5000 PPM | 100.0 100.0 100.0 96.0 96.0 92.0 92.0 88.0 86.0 80.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 2500 PPM 5000 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 68.0% 86.0% 80.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.234N P=0.066N P=0.319N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 629.6 569.6 539.1 |
|NATURAL DEATHS (C) | (29.7) (66.8) (43.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 696.5 705.8 690.2 |
|(STANDARD ERROR) | (11.4) (11.8) (13.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
2,4-DICHLOROPHENOL
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
5000 PPM = 2
10000 PPM = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 1
|
| 3 12 3 1
| 2 3 2 1 3 1
95 +
| 2 2 3 1 1 3
| 2 2 1 3 31
|
90 + 2 2 31 1
|
| 22 33
| 2 2 33
P 85 +
E | 2 2 3 31 1
R | 2 2 33
C |
E 80 + 22 3 11
N |
T | 22
| 22 311
S 75 +
U | 2 2 11
R | 22
V |
I 70 + 221 1
V |
A | 331 1
L | 33 1 1
65 +
| 22 3 3
| 22
|
60 + 22
|
|
|
55 +
| 2 2
|
|
50 + 2 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 9 obs hidden.
2,4-DICHLOROPHENOL
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
2500 PPM = 2
5000 PPM = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1 3
|
| 2 1 1 2
| 3 31 12 2
95 +
| 3 3 1 12 2
P | 3 3 1 1 2
E |
R 90 + 3 3 1 1 2 2
C |
E | 3 13 1 2 2
N | 3 13 1 2
T 85 +
| 33
S | 3 3
U |
R 80 + 3 3
V |
I | 11
V | 11
A 75 +
L | 11
|
|
70 + 1 1
|
| 1
|
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 3 obs hidden.
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