TDMS Study 05053-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) BROMOFORM NTP Experiment-Test: 05053-02 Report: PEIRPT03 Study Type: CHRONIC Date: 09/08/94 Route: GAVAGE Time: 02:48:02 Facility: TSI Mason Research Chemical CAS #: 75-25-2 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 02:48:02 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VF 46 LF 46 HF ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 Early Deaths Moribund Sacrifice 10 12 11 Natural Death 14 23 19 Survivors Terminal Sacrifice 25 13 20 Natural Death 2 Culled 1 Animals Examined Microscopically 49 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large (48) (24) (49) Lymphoid Nodule, Hyperplasia 1 (2%) 2 (4%) Intestine Small (47) (22) (48) Fibrosis 1 (2%) Inflammation, Acute 1 (2%) Mineralization 1 (5%) Necrosis 1 (2%) 1 (5%) Epithelium, Hyperplasia 1 (5%) Lymphoid Nodule, Hyperplasia 16 (34%) 5 (23%) 15 (31%) Liver (49) (50) (50) Abscess 1 (2%) Basophilic Focus 1 (2%) 1 (2%) Clear Cell Focus 1 (2%) Fatty Change, Diffuse 2 (4%) 4 (8%) Fatty Change, Focal 1 (2%) 7 (14%) 20 (40%) Hematopoietic Cell Proliferation 32 (65%) 34 (68%) 36 (72%) Infarct 1 (2%) 1 (2%) Inflammation, Chronic Active 1 (2%) 1 (2%) Mineralization 1 (2%) Necrosis 5 (10%) 4 (8%) 8 (16%) Pigmentation 3 (6%) 2 (4%) Mesentery (16) (19) (19) Inflammation, Acute 14 (88%) 19 (100%) 19 (100%) Fat, Necrosis 1 (6%) Pancreas (46) (26) (47) Necrosis, Coagulative 1 (2%) Acinus, Hyperplasia, Focal 1 (2%) Stomach (47) (48) (50) Forestomach, Acanthosis 2 (4%) 3 (6%) 2 (4%) Forestomach, Angiectasis 1 (2%) Forestomach, Hyperkeratosis 6 (13%) 13 (27%) 6 (12%) Forestomach, Inflammation, Chronic Active 4 (9%) 2 (4%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 02:48:02 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VF 46 LF 46 HF ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Glandular, Ectopic Tissue 1 (2%) Glandular, Hyperplasia 1 (2%) 4 (8%) 4 (8%) Glandular, Inflammation, Chronic Active 5 (11%) 5 (10%) 3 (6%) Glandular, Mineralization 1 (2%) Glandular, Necrosis 1 (2%) 3 (6%) 1 (2%) Glandular, Pigmentation 1 (2%) Tooth (1) Inflammation, Chronic Active 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (48) (26) (50) Cardiomyopathy 1 (2%) 2 (8%) 2 (4%) Mineralization 1 (4%) 1 (2%) Artery, Inflammation, Chronic Active 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (49) (26) (46) Accessory Adrenal Cortical Nodule 1 (2%) Hematopoietic Cell Proliferation 9 (18%) 8 (31%) 8 (17%) Capsule, Hyperplasia 38 (78%) 17 (65%) 38 (83%) Medulla, Hyperplasia 1 (2%) 1 (2%) Pituitary Gland (44) (27) (46) Pars Distalis, Angiectasis 4 (9%) 5 (19%) 2 (4%) Pars Distalis, Cyst 1 (2%) Pars Distalis, Hyperplasia 16 (36%) 7 (26%) 13 (28%) Pars Distalis, Pigmentation 1 (4%) Pars Intermedia, Hyperplasia 1 (4%) 1 (2%) Thyroid Gland (49) (49) (47) Follicular Cell, Cyst 1 (2%) Follicular Cell, Hyperplasia, Focal 4 (8%) 3 (6%) 17 (36%) Follicular Cell, Hyperplasia, Multifocal 1 (2%) 1 (2%) 2 (4%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 02:48:02 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VF 46 LF 46 HF ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (45) (36) (49) Abscess 13 (29%) 16 (44%) 19 (39%) Angiectasis 1 (2%) Cyst 11 (24%) 5 (14%) 4 (8%) Degeneration, Cystic 1 (3%) Hemorrhage 1 (2%) Mineralization 1 (2%) 2 (6%) Pigmentation 1 (3%) 1 (2%) Bilateral, Abscess 10 (22%) 15 (42%) 7 (14%) Oviduct (1) Inflammation, Acute 1 (100%) Uterus (49) (39) (49) Abscess 2 (4%) 1 (3%) 2 (4%) Angiectasis 1 (2%) 1 (3%) Hemorrhage 1 (2%) Inflammation, Acute 14 (29%) 12 (31%) 12 (24%) Necrosis 1 (2%) Endometrium, Hyperplasia 20 (41%) 19 (49%) 22 (45%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (49) (25) (50) Myelofibrosis 3 (6%) Lymph Node (44) (32) (45) Axillary, Hyperplasia, Plasma Cell 1 (3%) Inguinal, Hematopoietic Cell Proliferation 1 (2%) Inguinal, Hyperplasia, Plasma Cell 1 (2%) Lumbar, Angiectasis 1 (2%) Lumbar, Hematopoietic Cell Proliferation 2 (6%) 1 (2%) Lumbar, Hyperplasia, Lymphoid 1 (2%) Lumbar, Hyperplasia, Plasma Cell 4 (13%) 3 (7%) Lumbar, Infiltration Cellular, Plasma Cell 1 (2%) Lumbar, Necrosis 1 (2%) 1 (3%) Mandibular, Angiectasis 1 (2%) Mandibular, Hematopoietic Cell Proliferation 1 (2%) 7 (22%) 5 (11%) Mandibular, Inflammation, Acute 1 (2%) Mediastinal, Angiectasis 1 (2%) Mediastinal, Bacterium 1 (2%) Mediastinal, Hematopoietic Cell Proliferation 8 (18%) 4 (13%) 7 (16%) Mediastinal, Hemorrhage 1 (2%) Mediastinal, Hyperplasia, Plasma Cell 3 (7%) 4 (13%) 10 (22%) Mediastinal, Infiltration Cellular, Plasma Cell 4 (9%) Mediastinal, Inflammation, Acute 3 (7%) Mediastinal, Necrosis 4 (9%) 3 (9%) 5 (11%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 02:48:02 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VF 46 LF 46 HF ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Mesenteric, Angiectasis 7 (16%) 3 (9%) 5 (11%) Mesenteric, Hematopoietic Cell Proliferation 16 (36%) 9 (28%) 11 (24%) Mesenteric, Hemorrhage 1 (2%) 1 (3%) Mesenteric, Hyperplasia, Lymphoid 1 (2%) Mesenteric, Hyperplasia, Plasma Cell 2 (5%) 2 (6%) 2 (4%) Mesenteric, Infiltration Cellular, Plasma Cell 1 (2%) Pancreatic, Hematopoietic Cell Proliferation 2 (6%) Renal, Angiectasis 1 (2%) Renal, Hematopoietic Cell Proliferation 3 (7%) 4 (13%) 3 (7%) Renal, Hyperplasia, Lymphoid 1 (2%) Renal, Hyperplasia, Plasma Cell 2 (5%) 6 (19%) 3 (7%) Renal, Infiltration Cellular, Plasma Cell 2 (5%) Renal, Necrosis 1 (3%) 1 (2%) Spleen (48) (35) (50) Angiectasis 1 (2%) Hematopoietic Cell Proliferation 43 (90%) 32 (91%) 48 (96%) Hemorrhage 1 (3%) Hyperplasia, Lymphoid 4 (8%) 5 (10%) Necrosis 2 (4%) Pigmentation 1 (2%) Capsule, Fibrosis 1 (2%) Thymus (37) (14) (35) Atrophy 1 (3%) 1 (7%) 2 (6%) Cyst 1 (7%) Hyperplasia, Lymphoid 1 (3%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (17) (11) (13) Galactocele 2 (12%) Skin (40) (25) (44) Hyperkeratosis 1 (3%) Necrosis 1 (2%) Subcutaneous Tissue, Inflammation, Chronic Active 1 (3%) 1 (2%) Subcutaneous Tissue, Metaplasia, Osseous 1 (3%) Subcutaneous Tissue, Necrosis 1 (4%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (49) (25) (50) Joint, Hyperostosis 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 02:48:02 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VF 46 LF 46 HF ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (49) (25) (50) Inflammation, Acute 1 (4%) Thalamus, Mineralization 2 (4%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (49) (27) (50) Abscess 1 (2%) Bacterium 2 (4%) 4 (15%) 5 (10%) Edema 1 (4%) 1 (2%) Hemorrhage 6 (12%) Inflammation, Acute 4 (8%) Inflammation, Chronic Active 4 (8%) 4 (15%) 4 (8%) Alveolar Epithelium, Hyperplasia 1 (2%) 3 (6%) Pleura, Inflammation, Acute 4 (8%) 11 (41%) 9 (18%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Harderian Gland (2) Hyperplasia 1 (50%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (49) (32) (50) Cyst 1 (2%) Glomerulosclerosis 1 (2%) Inflammation, Acute 1 (2%) 3 (9%) 1 (2%) Inflammation, Chronic 1 (2%) 1 (3%) Inflammation, Chronic Active 7 (14%) 4 (13%) 11 (22%) Metaplasia, Osseous 1 (2%) Necrosis 1 (3%) Pigmentation 1 (2%) Cortex, Mineralization 1 (2%) 1 (3%) 2 (4%) Glomerulus, Inflammation, Acute 5 (10%) 6 (19%) 5 (10%) Papilla, Mineralization 5 (10%) 3 (6%) Papilla, Necrosis 1 (2%) 2 (6%) 1 (2%) Renal Tubule, Casts 1 (2%) Renal Tubule, Regeneration 2 (4%) a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 02:48:02 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE .05 G/KG 0.1 G/KG 46 VM 46 LM 46 HM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 Early Deaths Natural Death 4 7 10 Moribund Sacrifice 5 6 4 Survivors Terminal Sacrifice 41 37 36 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (46) (6) (30) Inflammation, Chronic Active 2 (4%) 1 (3%) Intestine Large (50) (7) (48) Circumanal Gland, Inflammation, Acute 1 (14%) Lymphoid Nodule, Hyperplasia 2 (4%) 1 (14%) 5 (10%) Intestine Small (50) (6) (46) Hyperplasia, Lymphoid 1 (2%) Duodenum, Fibrosis 1 (17%) Duodenum, Hyperplasia 1 (17%) Duodenum, Inflammation, Chronic Active 1 (17%) Duodenum, Necrosis 1 (17%) Ileum, Epithelium, Hyperplasia 1 (2%) Lymphoid Nodule, Hyperplasia 26 (52%) 21 (46%) Lymphoid Nodule, Necrosis 1 (2%) Liver (50) (50) (49) Basophilic Focus 2 (4%) 2 (4%) Cyst 1 (2%) Fatty Change, Diffuse 1 (2%) Fatty Change, Focal 7 (14%) 5 (10%) 7 (14%) Fibrosis 1 (2%) Hematopoietic Cell Proliferation 20 (40%) 5 (10%) 14 (29%) Hemorrhage 1 (2%) 1 (2%) Infarct 1 (2%) Mineralization 3 (6%) 3 (6%) 3 (6%) Necrosis 10 (20%) 8 (16%) 12 (24%) Pigmentation 1 (2%) Regeneration 1 (2%) Thrombosis 1 (2%) Bile Duct, Hyperplasia 1 (2%) Mesentery (2) (1) Abscess 1 (100%) Fat, Necrosis 1 (50%) Pancreas (49) (9) (48) Acinus, Atrophy 1 (2%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 02:48:02 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE .05 G/KG 0.1 G/KG 46 VM 46 LM 46 HM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Acinus, Hyperplasia 2 (4%) 1 (2%) Stomach (50) (50) (49) Hyperplasia, Glandular 1 (2%) 1 (2%) Inflammation, Chronic Active 1 (2%) Forestomach, Acanthosis 4 (8%) 3 (6%) 6 (12%) Forestomach, Cyst Epithelial Inclusion, Multiple 1 (2%) Forestomach, Fibrosis 1 (2%) 1 (2%) Forestomach, Hyperkeratosis 5 (10%) 5 (10%) 7 (14%) Forestomach, Inflammation, Chronic Active 1 (2%) 2 (4%) 2 (4%) Forestomach, Mineralization 1 (2%) Forestomach, Ulcer 2 (4%) 2 (4%) 2 (4%) Glandular, Cyst 1 (2%) Glandular, Dysplasia 1 (2%) Glandular, Hyperplasia 4 (8%) 6 (12%) Glandular, Inflammation, Chronic Active 4 (8%) 6 (12%) 8 (16%) Glandular, Mineralization 1 (2%) Tooth (1) Developmental Malformation 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (6) (48) Cardiomyopathy 2 (4%) Mineralization 1 (2%) Artery, Inflammation, Chronic Active 1 (2%) Pericardium, Inflammation, Acute 1 (17%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (49) (9) (49) Capsule, Hyperplasia 31 (63%) 6 (67%) 30 (61%) Cortex, Hyperplasia 1 (2%) 2 (4%) Cortex, Hypertrophy 1 (11%) 2 (4%) Cortex, Hypertrophy, Diffuse 1 (2%) Cortex, Hypertrophy, Focal 1 (2%) Medulla, Hyperplasia 8 (16%) 1 (11%) 4 (8%) Islets, Pancreatic (49) (9) (48) Hyperplasia 1 (2%) Pituitary Gland (45) (6) (40) Pars Distalis, Cyst 2 (4%) 1 (17%) 1 (3%) Pars Distalis, Hyperplasia 3 (7%) Pars Intermedia, Cyst 1 (2%) Thyroid Gland (48) (6) (46) Follicle, Cyst 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 8 NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 02:48:02 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE .05 G/KG 0.1 G/KG 46 VM 46 LM 46 HM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Follicular Cell, Hyperplasia, Focal 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (47) (7) (47) Abscess 1 (14%) Preputial Gland (7) (9) (10) Cyst 3 (33%) Dilatation 1 (14%) Inflammation, Chronic Active 5 (71%) 2 (22%) 5 (50%) Necrosis 1 (14%) 3 (33%) 5 (50%) Prostate (46) (6) (45) Hemorrhage 1 (17%) Inflammation, Chronic Active 1 (2%) 1 (17%) 2 (4%) Necrosis 1 (17%) Seminal Vesicle (49) (10) (48) Inflammation, Chronic Active 1 (2%) 1 (10%) Testes (50) (9) (48) Spermatocele 1 (11%) Seminiferous Tubule, Atrophy 7 (14%) 1 (11%) 6 (13%) Seminiferous Tubule, Mineralization 1 (2%) 1 (11%) 3 (6%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (47) (15) (43) Lumbar, Angiectasis 1 (2%) Lumbar, Hematopoietic Cell Proliferation 1 (2%) Lumbar, Hyperplasia, Plasma Cell 1 (2%) 1 (7%) Mandibular, Infiltration Cellular, Plasma Cell 1 (2%) Mesenteric, Angiectasis 22 (47%) 10 (67%) 14 (33%) Mesenteric, Hematopoietic Cell Proliferation 15 (32%) 10 (67%) 10 (23%) Mesenteric, Necrosis 1 (2%) Pancreatic, Hematopoietic Cell Proliferation 1 (7%) Renal, Necrosis 1 (2%) Thoracic, Angiectasis 1 (2%) Thoracic, Necrosis 1 (2%) Spleen (50) (18) (49) Angiectasis 2 (4%) 1 (6%) Atrophy 1 (2%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 9 NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 02:48:02 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE .05 G/KG 0.1 G/KG 46 VM 46 LM 46 HM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Hematopoietic Cell Proliferation 40 (80%) 15 (83%) 38 (78%) Hyperplasia, Lymphoid 3 (6%) 1 (2%) Hyperplasia, Mast Cell 1 (6%) Thymus (35) (6) (30) Atrophy 3 (9%) 2 (33%) Hyperplasia, Lymphoid 1 (3%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (48) (23) (49) Bacterium 1 (2%) 3 (13%) 2 (4%) Hemorrhage 1 (4%) 1 (2%) Hyperplasia, Basal Cell 1 (4%) Inflammation, Acute 1 (4%) Inflammation, Chronic Active 2 (9%) Necrosis 4 (8%) 8 (35%) 8 (16%) Prepuce, Acanthosis 1 (2%) Prepuce, Inflammation, Chronic Active 1 (4%) 1 (2%) Prepuce, Necrosis 2 (4%) Sebaceous Gland, Hyperplasia 1 (4%) Subcutaneous Tissue, Fibrosis 3 (13%) 2 (4%) Subcutaneous Tissue, Inflammation, Chronic Active 1 (4%) Subcutaneous Tissue, Metaplasia, Osseous 1 (2%) Subcutaneous Tissue, Necrosis 1 (2%) 1 (4%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (49) (49) Joint, Tarsal, Hyperostosis 35 (70%) 40 (82%) 27 (55%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (6) (48) Inflammation, Acute 1 (2%) Inflammation, Chronic 1 (2%) Mineralization 1 (2%) Thalamus, Mineralization 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 10 NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 02:48:02 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE .05 G/KG 0.1 G/KG 46 VM 46 LM 46 HM ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (49) Abscess 1 (2%) Embolus Tumor 1 (2%) Fungus 1 (2%) Hemorrhage 7 (14%) 4 (8%) 7 (14%) Infiltration Cellular, Histiocyte 2 (4%) 2 (4%) Inflammation, Chronic Active 2 (4%) 1 (2%) Alveolar Epithelium, Hyperplasia 3 (6%) 2 (4%) 1 (2%) Bronchiole, Inflammation, Acute 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Harderian Gland (2) (2) (3) Abscess 1 (33%) Fibrosis 1 (33%) Fungus 1 (33%) Inflammation, Chronic Active 1 (33%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (20) (49) Abscess 1 (2%) Cyst 4 (8%) 1 (5%) Embolus Tumor 1 (2%) Inflammation, Chronic Active 3 (6%) 4 (20%) 2 (4%) Cortex, Mineralization 19 (38%) 2 (10%) 10 (20%) Papilla, Mineralization 1 (2%) 1 (2%) Papilla, Necrosis 1 (2%) Renal Tubule, Casts 5 (10%) 1 (5%) 4 (8%) Renal Tubule, Degeneration 1 (2%) 1 (2%) Renal Tubule, Regeneration 18 (36%) 4 (20%) 8 (16%) Urinary Bladder (48) (7) (47) Angiectasis 1 (14%) Calculus Micro Observation Only 2 (4%) Inflammation, Acute 1 (14%) Inflammation, Chronic 1 (14%) Inflammation, Chronic Active 1 (2%) 1 (14%) Transitional Epithelium, Hyperplasia 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 11 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------