TDMS Study 05053-02 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) BROMOFORM NTP Experiment-Test: 05053-02 Report: PEIRPT05 Study Type: CHRONIC Date: 09/08/94 Route: GAVAGE Time: 02:48:02 Facility: TSI Mason Research Chemical CAS #: 75-25-2 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 02:48:02 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VF 46 LF 46 HF ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 Early Deaths Moribund Sacrifice 10 12 11 Natural Death 14 23 19 Survivors Terminal Sacrifice 25 13 20 Natural Death 2 Culled 1 Animals Examined Microscopically 49 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (38) (16) (37) Intestine Large (48) (24) (49) Intestine Small (47) (22) (48) Liver (49) (50) (50) Hemangiosarcoma 2 (4%) Hepatocellular Carcinoma 1 (2%) 2 (4%) Hepatocellular Adenoma 1 (2%) 5 (10%) 3 (6%) Hepatocellular Adenoma, Multiple 2 (4%) 1 (2%) 1 (2%) Hepatocholangiocarcinoma, Multiple 1 (2%) Histiocytic Sarcoma 1 (2%) Mesentery (16) (19) (19) Pancreas (46) (26) (47) Salivary Glands (46) (24) (45) Stomach (47) (48) (50) Forestomach, Squamous Cell Papilloma 2 (4%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (48) (26) (50) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (49) (26) (46) Islets, Pancreatic (46) (25) (47) Adenoma 1 (4%) Pituitary Gland (44) (27) (46) Pars Distalis, Adenoma 7 (16%) 6 (22%) 5 (11%) Pars Distalis, Adenoma, Multiple 1 (2%) Pars Intermedia, Adenoma 1 (2%) Page 2 NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 02:48:02 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VF 46 LF 46 HF ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont Thyroid Gland (49) (49) (47) Follicular Cell, Adenoma 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (45) (36) (49) Uterus (49) (39) (49) Histiocytic Sarcoma 1 (3%) Leiomyosarcoma 1 (2%) Polyp Stromal 1 (2%) 1 (3%) 3 (6%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (49) (25) (50) Lymph Node (44) (32) (45) Spleen (48) (35) (50) Hemangiosarcoma 1 (2%) Thymus (37) (14) (35) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (40) (25) (44) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (49) (25) (50) ____________________________________________________________________________________________________________________________________ Page 3 NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 02:48:02 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VF 46 LF 46 HF ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (49) (27) (50) Alveolar/Bronchiolar Adenoma 2 (4%) 1 (4%) 2 (4%) Alveolar/Bronchiolar Carcinoma 1 (2%) Osteosarcoma, Metastatic 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Harderian Gland (2) Adenoma 1 (50%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (49) (32) (50) Osteosarcoma, Metastatic 1 (2%) Urinary Bladder (47) (17) (48) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(49) *(50) *(50) Histiocytic Sarcoma 1 (2%) Lymphoma Malignant Histiocytic 1 (2%) 1 (2%) Lymphoma Malignant Lymphocytic 4 (8%) 1 (2%) Lymphoma Malignant Mixed 3 (6%) 2 (4%) 2 (4%) Lymphoma Malignant Undifferentiated Cell 3 (6%) 2 (4%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 4 NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 02:48:02 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VF 46 LF 46 HF ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 24 18 18 Total Primary Neoplasms 30 22 25 Total Animals with Benign Neoplasms 11 13 15 Total Benign Neoplasms 15 16 17 Total Animals with Malignant Neoplasms 15 6 8 Total Malignant Neoplasms 15 6 8 Total Animals with Metastatic Neoplasms 1 Total Metastatic Neoplasm 2 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 5 NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 02:48:02 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE .05 G/KG 0.1 G/KG 46 VM 46 LM 46 HM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 Early Deaths Natural Death 4 7 10 Moribund Sacrifice 5 6 4 Survivors Terminal Sacrifice 41 37 36 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (46) (6) (30) Intestine Small (50) (6) (46) Hepatocholangiocarcinoma, Metastatic 1 (2%) Polyp Adenomatous 1 (2%) Liver (50) (50) (49) Hemangioma 1 (2%) 1 (2%) Hemangiosarcoma 1 (2%) Hemangiosarcoma, Multiple 1 (2%) 2 (4%) Hepatocellular Carcinoma 5 (10%) 6 (12%) 6 (12%) Hepatocellular Carcinoma, Multiple 2 (4%) 2 (4%) Hepatocellular Adenoma 10 (20%) 9 (18%) 8 (16%) Hepatocellular Adenoma, Multiple 1 (2%) 2 (4%) Hepatocholangiocarcinoma 1 (2%) Osteosarcoma, Metastatic 1 (2%) Pancreas (49) (9) (48) Stomach (50) (50) (49) Forestomach, Squamous Cell Papilloma 4 (8%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (49) (9) (49) Osteosarcoma, Metastatic 1 (11%) Capsule, Adenoma 1 (2%) 1 (11%) 1 (2%) Medulla, Pheochromocytoma Benign 1 (2%) Thyroid Gland (48) (6) (46) Follicular Cell, Adenoma 1 (2%) ____________________________________________________________________________________________________________________________________ Page 6 NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 02:48:02 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE .05 G/KG 0.1 G/KG 46 VM 46 LM 46 HM ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM None ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (6) (48) Lymph Node (47) (15) (43) Mediastinal, Hepatocholangiocarcinoma, Metastatic 1 (2%) Spleen (50) (18) (49) Hemangioma 1 (2%) Thymus (35) (6) (30) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (1) Adenoma 1 (100%) Skin (48) (23) (49) Subcutaneous Tissue, Fibroma 3 (6%) 5 (22%) 2 (4%) Subcutaneous Tissue, Fibrosarcoma 2 (4%) 7 (30%) 4 (8%) Subcutaneous Tissue, Hemangioma 1 (2%) Subcutaneous Tissue, Neurofibrosarcoma 1 (2%) 1 (4%) Subcutaneous Tissue, Sarcoma 1 (4%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ Page 7 NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 02:48:02 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE .05 G/KG 0.1 G/KG 46 VM 46 LM 46 HM ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (49) Alveolar/Bronchiolar Adenoma 10 (20%) 5 (10%) 2 (4%) Alveolar/Bronchiolar Carcinoma 1 (2%) 2 (4%) Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%) Fibrosarcoma, Metastatic, Skin 1 (2%) Hepatocellular Carcinoma, Metastatic 2 (4%) 3 (6%) 2 (4%) Hepatocholangiocarcinoma, Metastatic 1 (2%) Osteosarcoma, Metastatic 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Harderian Gland (2) (2) (3) Adenoma 2 (100%) 1 (50%) 1 (33%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (20) (49) Hepatocholangiocarcinoma, Metastatic 1 (2%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) Lymphoma Malignant 1 (2%) Lymphoma Malignant Histiocytic 1 (2%) 1 (2%) Lymphoma Malignant Lymphocytic 1 (2%) 2 (4%) Lymphoma Malignant Mixed 1 (2%) Lymphoma Malignant Undifferentiated Cell 3 (6%) 1 (2%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 8 NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 02:48:02 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE .05 G/KG 0.1 G/KG 46 VM 46 LM 46 HM ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 34 33 27 Total Primary Neoplasms 52 49 32 Total Animals with Benign Neoplasms 25 24 13 Total Benign Neoplasms 33 28 15 Total Animals with Malignant Neoplasms 17 20 15 Total Malignant Neoplasms 19 21 17 Total Animals with Metastatic Neoplasms 3 5 2 Total Metastatic Neoplasm 6 7 2 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 9 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------