TDMS Study 05053-02 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
BROMOFORM
NTP Experiment-Test: 05053-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/08/94
Route: GAVAGE Time: 02:48:02
Facility: TSI Mason Research
Chemical CAS #: 75-25-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 02:48:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VF 46 LF 46 HF
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund Sacrifice 10 12 11
Natural Death 14 23 19
Survivors
Terminal Sacrifice 25 13 20
Natural Death 2
Culled 1
Animals Examined Microscopically 49 50 50
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ALIMENTARY SYSTEM
Gallbladder (38) (16) (37)
Intestine Large (48) (24) (49)
Intestine Small (47) (22) (48)
Liver (49) (50) (50)
Hemangiosarcoma 2 (4%)
Hepatocellular Carcinoma 1 (2%) 2 (4%)
Hepatocellular Adenoma 1 (2%) 5 (10%) 3 (6%)
Hepatocellular Adenoma, Multiple 2 (4%) 1 (2%) 1 (2%)
Hepatocholangiocarcinoma, Multiple 1 (2%)
Histiocytic Sarcoma 1 (2%)
Mesentery (16) (19) (19)
Pancreas (46) (26) (47)
Salivary Glands (46) (24) (45)
Stomach (47) (48) (50)
Forestomach, Squamous Cell Papilloma 2 (4%)
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CARDIOVASCULAR SYSTEM
Heart (48) (26) (50)
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ENDOCRINE SYSTEM
Adrenal Gland (49) (26) (46)
Islets, Pancreatic (46) (25) (47)
Adenoma 1 (4%)
Pituitary Gland (44) (27) (46)
Pars Distalis, Adenoma 7 (16%) 6 (22%) 5 (11%)
Pars Distalis, Adenoma, Multiple 1 (2%)
Pars Intermedia, Adenoma 1 (2%)
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NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 02:48:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VF 46 LF 46 HF
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Thyroid Gland (49) (49) (47)
Follicular Cell, Adenoma 1 (2%)
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GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (45) (36) (49)
Uterus (49) (39) (49)
Histiocytic Sarcoma 1 (3%)
Leiomyosarcoma 1 (2%)
Polyp Stromal 1 (2%) 1 (3%) 3 (6%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (25) (50)
Lymph Node (44) (32) (45)
Spleen (48) (35) (50)
Hemangiosarcoma 1 (2%)
Thymus (37) (14) (35)
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INTEGUMENTARY SYSTEM
Skin (40) (25) (44)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (25) (50)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 02:48:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VF 46 LF 46 HF
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (27) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 1 (4%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Osteosarcoma, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (2)
Adenoma 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (32) (50)
Osteosarcoma, Metastatic 1 (2%)
Urinary Bladder (47) (17) (48)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(49) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Lymphoma Malignant Histiocytic 1 (2%) 1 (2%)
Lymphoma Malignant Lymphocytic 4 (8%) 1 (2%)
Lymphoma Malignant Mixed 3 (6%) 2 (4%) 2 (4%)
Lymphoma Malignant Undifferentiated Cell 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 02:48:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VF 46 LF 46 HF
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 24 18 18
Total Primary Neoplasms 30 22 25
Total Animals with Benign Neoplasms 11 13 15
Total Benign Neoplasms 15 16 17
Total Animals with Malignant Neoplasms 15 6 8
Total Malignant Neoplasms 15 6 8
Total Animals with Metastatic Neoplasms 1
Total Metastatic Neoplasm 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 5
NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 02:48:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE .05 G/KG 0.1 G/KG
46 VM 46 LM 46 HM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Natural Death 4 7 10
Moribund Sacrifice 5 6 4
Survivors
Terminal Sacrifice 41 37 36
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (46) (6) (30)
Intestine Small (50) (6) (46)
Hepatocholangiocarcinoma, Metastatic 1 (2%)
Polyp Adenomatous 1 (2%)
Liver (50) (50) (49)
Hemangioma 1 (2%) 1 (2%)
Hemangiosarcoma 1 (2%)
Hemangiosarcoma, Multiple 1 (2%) 2 (4%)
Hepatocellular Carcinoma 5 (10%) 6 (12%) 6 (12%)
Hepatocellular Carcinoma, Multiple 2 (4%) 2 (4%)
Hepatocellular Adenoma 10 (20%) 9 (18%) 8 (16%)
Hepatocellular Adenoma, Multiple 1 (2%) 2 (4%)
Hepatocholangiocarcinoma 1 (2%)
Osteosarcoma, Metastatic 1 (2%)
Pancreas (49) (9) (48)
Stomach (50) (50) (49)
Forestomach, Squamous Cell Papilloma 4 (8%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (9) (49)
Osteosarcoma, Metastatic 1 (11%)
Capsule, Adenoma 1 (2%) 1 (11%) 1 (2%)
Medulla, Pheochromocytoma Benign 1 (2%)
Thyroid Gland (48) (6) (46)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 6
NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 02:48:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE .05 G/KG 0.1 G/KG
46 VM 46 LM 46 HM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (6) (48)
Lymph Node (47) (15) (43)
Mediastinal, Hepatocholangiocarcinoma,
Metastatic 1 (2%)
Spleen (50) (18) (49)
Hemangioma 1 (2%)
Thymus (35) (6) (30)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (1)
Adenoma 1 (100%)
Skin (48) (23) (49)
Subcutaneous Tissue, Fibroma 3 (6%) 5 (22%) 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 7 (30%) 4 (8%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Neurofibrosarcoma 1 (2%) 1 (4%)
Subcutaneous Tissue, Sarcoma 1 (4%)
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MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 02:48:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE .05 G/KG 0.1 G/KG
46 VM 46 LM 46 HM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49)
Alveolar/Bronchiolar Adenoma 10 (20%) 5 (10%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 2 (4%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hepatocellular Carcinoma, Metastatic 2 (4%) 3 (6%) 2 (4%)
Hepatocholangiocarcinoma, Metastatic 1 (2%)
Osteosarcoma, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (2) (2) (3)
Adenoma 2 (100%) 1 (50%) 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (20) (49)
Hepatocholangiocarcinoma, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Lymphoma Malignant 1 (2%)
Lymphoma Malignant Histiocytic 1 (2%) 1 (2%)
Lymphoma Malignant Lymphocytic 1 (2%) 2 (4%)
Lymphoma Malignant Mixed 1 (2%)
Lymphoma Malignant Undifferentiated Cell 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 8
NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 02:48:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE .05 G/KG 0.1 G/KG
46 VM 46 LM 46 HM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 34 33 27
Total Primary Neoplasms 52 49 32
Total Animals with Benign Neoplasms 25 24 13
Total Benign Neoplasms 33 28 15
Total Animals with Malignant Neoplasms 17 20 15
Total Malignant Neoplasms 19 21 17
Total Animals with Metastatic Neoplasms 3 5 2
Total Metastatic Neoplasm 6 7 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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