TDMS Study 05053-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason BROMOFORM DATE: 09/08/94
EXPERIMENT: 05053 TEST: 02 TIME: 02:59:35
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01ES2803301 ROUTE: GAVAGE NTP C#: 55130
PATHOLOGIST: K. MURTHY CAS: 75-25-2
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason BROMOFORM DATE: 09/08/94
EXPERIMENT: 05053 TEST: 02 TIME: 02:59:35
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES2803301 ROUTE: GAVAGE NTP C#: 55130
PATHOLOGIST: K. MURTHY CAS: 75-25-2
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason BROMOFORM DATE: 09/08/94
EXPERIMENT: 05053 TEST: 02 TIME: 02:59:35
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES2803301 ROUTE: GAVAGE NTP C#: 55130
PATHOLOGIST: K. MURTHY CAS: 75-25-2
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF BROMOFORM
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Skin: Subcutaneous Tissue Neurofibrosarcoma, Fibrosarcoma, or Sarcoma
All Organs Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Benign Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
All Organs Hemangiosarcoma
Hemangiosarcoma or Hemangioma
Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
====================================================================================================
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .05 G/KG 0.1 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 1/50 (2%) | 0/49 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 4.9% 2.1% 2.8% | 0.0% 6.7% 0.0% |
|TERMINAL (d) | 2/41 (5%) 0/37 (0%) 1/36 (3%) | 0/25 (0%) 1/15 (7%) 0/20 (0%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 532 730 (T) | --- 735 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.417N P=0.529N P=0.545N | P=0.686 P=0.398 (e) |
|INCIDENTAL TUMOR | P=0.339N P=0.477N P=0.545N | P=0.686 P=0.398 (e) |
|LOGISTIC REGRESSION | P=0.360N P=0.455N P=0.545N | P=0.686 P=0.398 (e) |
|COCHRAN-ARMITAGE | P=0.378N | P=0.728N |
|FISHER EXACT | P=0.500N P=0.500N | P=0.505 (e) |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 2/49 (4%) | 0/49 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 2.4% 2.7% 5.3% | 0.0% 0.0% 7.0% |
|TERMINAL (d) | 1/41 (2%) 1/37 (3%) 1/36 (3%) | 0/25 (0%) 0/15 (0%) 1/20 (5%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 730 (T) 663 | --- --- 372 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.338 P=0.739 P=0.453 | P=0.090 (e) P=0.213 |
|INCIDENTAL TUMOR | P=0.345 P=0.739 P=0.470 | P=0.114 (e) P=0.381 |
|LOGISTIC REGRESSION | P=0.351 P=0.739 P=0.481 | P=0.151 (e) P=0.403 |
|COCHRAN-ARMITAGE | P=0.372 | P=0.097 |
|FISHER EXACT | P=0.753N P=0.492 | (e) P=0.253 |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .05 G/KG 0.1 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/50 (22%) 11/50 (22%) 8/49 (16%) | 3/49 (6%) 6/50 (12%) 4/50 (8%) |
|ADJUSTED (b) | 24.6% 26.8% 21.4% | 12.0% 21.1% 15.7% |
|TERMINAL (d) | 8/41 (20%) 8/37 (22%) 7/36 (19%) | 3/25 (12%) 0/15 (0%) 2/20 (10%) |
|FIRST INCIDENCE (DAYS) | 455 393 632 | 735 (T) 538 566 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.383N P=0.500 P=0.419N | P=0.278 P=0.092 P=0.376 |
|INCIDENTAL TUMOR | P=0.283N P=0.576N P=0.330N | P=0.359 P=0.251 P=0.391 |
|LOGISTIC REGRESSION | P=0.283N P=0.561N P=0.334N | P=0.398 P=0.248 P=0.391 |
|COCHRAN-ARMITAGE | P=0.282N | P=0.442 |
|FISHER EXACT | P=0.595N P=0.323N | P=0.254 P=0.511 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 8/50 (16%) 6/49 (12%) | 1/49 (2%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 15.4% 19.3% 14.4% | 3.0% 0.0% 8.3% |
|TERMINAL (d) | 3/41 (7%) 5/37 (14%) 2/36 (6%) | 0/25 (0%) 0/15 (0%) 1/20 (5%) |
|FIRST INCIDENCE (DAYS) | 642 602 509 | 692 --- 635 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.552N P=0.421 P=0.603N | P=0.283 P=0.632N P=0.392 |
|INCIDENTAL TUMOR | P=0.403N P=0.510 P=0.449N | P=0.316 P=0.519N P=0.440 |
|LOGISTIC REGRESSION | P=0.344N P=0.507 P=0.381N | P=0.313 P=0.549N P=0.452 |
|COCHRAN-ARMITAGE | P=0.459N | P=0.366 |
|FISHER EXACT | P=0.500 P=0.516N | P=0.495N P=0.508 |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .05 G/KG 0.1 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 16/50 (32%) 19/50 (38%) 14/49 (29%) | 4/49 (8%) 6/50 (12%) 6/50 (12%) |
|ADJUSTED (b) | 33.8% 43.5% 33.6% | 14.7% 21.1% 23.1% |
|TERMINAL (d) | 10/41 (24%) 13/37 (35%) 9/36 (25%) | 3/25 (12%) 0/15 (0%) 3/20 (15%) |
|FIRST INCIDENCE (DAYS) | 455 393 509 | 692 538 566 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.527 P=0.247 P=0.575N | P=0.175 P=0.149 P=0.226 |
|INCIDENTAL TUMOR | P=0.358N P=0.338 P=0.394N | P=0.238 P=0.377 P=0.256 |
|LOGISTIC REGRESSION | P=0.370N P=0.375 P=0.376N | P=0.265 P=0.369 P=0.258 |
|COCHRAN-ARMITAGE | P=0.401N | P=0.326 |
|FISHER EXACT | P=0.338 P=0.440N | P=0.383 P=0.383 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 16/50 (32%) 19/50 (38%) 14/49 (29%) | 4/49 (8%) 6/50 (12%) 6/50 (12%) |
|ADJUSTED (b) | 33.8% 43.5% 33.6% | 14.7% 21.1% 23.1% |
|TERMINAL (d) | 10/41 (24%) 13/37 (35%) 9/36 (25%) | 3/25 (12%) 0/15 (0%) 3/20 (15%) |
|FIRST INCIDENCE (DAYS) | 455 393 509 | 692 538 566 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.527 P=0.247 P=0.575N | P=0.175 P=0.149 P=0.226 |
|INCIDENTAL TUMOR | P=0.358N P=0.338 P=0.394N | P=0.238 P=0.377 P=0.256 |
|LOGISTIC REGRESSION | P=0.370N P=0.375 P=0.376N | P=0.265 P=0.369 P=0.258 |
|COCHRAN-ARMITAGE | P=0.401N | P=0.326 |
|FISHER EXACT | P=0.338 P=0.440N | P=0.383 P=0.383 |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .05 G/KG 0.1 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 5/50 (10%) 2/49 (4%) | 2/49 (4%) 1/27 (4%) 2/50 (4%) |
|ADJUSTED (b) | 24.4% 12.7% 5.6% | 8.0% 0.0% 7.4% |
|TERMINAL (d) | 10/41 (24%) 4/37 (11%) 2/36 (6%) | 2/25 (8%) 0/0 1/20 (5%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 602 730 (T) | 735 (T) 633 560 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.016N* P=0.178N P=0.026N* | P=0.501 P=0.424 P=0.616 |
|INCIDENTAL TUMOR | P=0.015N* P=0.192N P=0.026N* | P=0.552 P=0.545 P=0.648 |
|LOGISTIC REGRESSION | P=0.016N* P=0.162N P=0.026N* | P=0.523 P=0.381 P=0.641 |
|COCHRAN-ARMITAGE | P=0.010N** | P=0.594N |
|FISHER EXACT | P=0.131N P=0.015N* | P=0.714N P=0.684N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 0/49 (0%) | 1/49 (2%) 0/27 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.4% 7.4% 0.0% | 4.0% 0.0% 0.0% |
|TERMINAL (d) | 1/41 (2%) 2/37 (5%) 0/36 (0%) | 1/25 (4%) 0/0 0/20 (0%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 507 --- | 735 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.412N P=0.278 P=0.526N | P=0.348N (e) P=0.545N |
|INCIDENTAL TUMOR | P=0.339N P=0.314 P=0.526N | P=0.348N (e) P=0.545N |
|LOGISTIC REGRESSION | P=0.361N P=0.334 P=0.526N | P=0.348N (e) P=0.545N |
|COCHRAN-ARMITAGE | P=0.384N | P=0.283N |
|FISHER EXACT | P=0.309 P=0.505N | P=0.645N P=0.495N |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .05 G/KG 0.1 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/50 (22%) 7/50 (14%) 2/49 (4%) | 3/49 (6%) 1/27 (4%) 2/50 (4%) |
|ADJUSTED (b) | 26.8% 17.2% 5.6% | 12.0% 0.0% 7.4% |
|TERMINAL (d) | 11/41 (27%) 5/37 (14%) 2/36 (6%) | 3/25 (12%) 0/0 1/20 (5%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 507 730 (T) | 735 (T) 633 560 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.012N* P=0.288N P=0.015N* | P=0.519N P=0.424 P=0.598N |
|INCIDENTAL TUMOR | P=0.009N** P=0.285N P=0.015N* | P=0.472N P=0.545 P=0.567N |
|LOGISTIC REGRESSION | P=0.009N** P=0.236N P=0.015N* | P=0.513N P=0.371 P=0.595N |
|COCHRAN-ARMITAGE | P=0.007N** | P=0.398N |
|FISHER EXACT | P=0.218N P=0.008N** | P=0.553N P=0.490N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/45 (0%) 0/6 (0%) 0/40 (0%) | 7/44 (16%) 6/27 (22%) 6/46 (13%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 25.5% 65.9% 28.3% |
|TERMINAL (d) | 0/38 (0%) 0/0 0/32 (0%) | 4/22 (18%) 3/5 (60%) 5/20 (25%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 600 628 672 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.512 P=0.094 P=0.605 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.458 P=0.030 * P=0.580 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.472 P=0.023 * P=0.579 |
|COCHRAN-ARMITAGE | (e) | P=0.407N |
|FISHER EXACT | (e) (e) | P=0.358 P=0.465N |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .05 G/KG 0.1 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 5/50 (10%) 2/50 (4%) | 0/49 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 7.3% 13.1% 5.6% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/41 (7%) 4/37 (11%) 2/36 (6%) | 0/25 (0%) 0/15 (0%) 0/20 (0%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 688 730 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.495N P=0.300 P=0.559N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.483N P=0.344 P=0.559N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.499N P=0.310 P=0.559N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.421N | (e) |
|FISHER EXACT | P=0.357 P=0.500N | (e) (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 7/50 (14%) 4/50 (8%) | 0/49 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 4.8% 17.4% 9.9% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/41 (2%) 4/37 (11%) 2/36 (6%) | 0/25 (0%) 0/15 (0%) 0/20 (0%) |
|FIRST INCIDENCE (DAYS) | 721 673 526 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.233 P=0.063 P=0.289 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.284 P=0.121 P=0.371 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.297 P=0.071 P=0.382 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.297 | (e) |
|FISHER EXACT | P=0.080 P=0.339 | (e) (e) |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .05 G/KG 0.1 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 11/50 (22%) 6/50 (12%) | 0/49 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 13.8% 27.5% 15.2% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 4/41 (10%) 8/37 (22%) 4/36 (11%) | 0/25 (0%) 0/15 (0%) 0/20 (0%) |
|FIRST INCIDENCE (DAYS) | 629 673 526 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.441 P=0.105 P=0.532 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.533 P=0.158 P=0.601N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.523 P=0.120 P=0.609N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.555 | (e) |
|FISHER EXACT | P=0.143 P=0.620N | (e) (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 9/50 (18%) 4/50 (8%) | 0/49 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 6.8% 22.5% 9.9% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/41 (2%) 6/37 (16%) 2/36 (6%) | 0/25 (0%) 0/15 (0%) 0/20 (0%) |
|FIRST INCIDENCE (DAYS) | 629 673 526 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.349 P=0.048 * P=0.438 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.447 P=0.079 P=0.576 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.437 P=0.055 P=0.577 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.436 | (e) |
|FISHER EXACT | P=0.061 P=0.500 | (e) (e) |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .05 G/KG 0.1 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 4/50 (8%) 0/50 (0%) | 0/49 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 10.8% 0.0% | 0.0% 0.0% 8.0% |
|TERMINAL (d) | 0/41 (0%) 4/37 (11%) 0/36 (0%) | 0/25 (0%) 0/15 (0%) 1/20 (5%) |
|FIRST INCIDENCE (DAYS) | --- 730 (T) --- | --- --- 609 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.579 P=0.051 (e) | P=0.083 (e) P=0.190 |
|INCIDENTAL TUMOR | P=0.579 P=0.051 (e) | P=0.095 (e) P=0.231 |
|LOGISTIC REGRESSION | P=0.579 P=0.051 (e) | P=0.084 (e) P=0.220 |
|COCHRAN-ARMITAGE | P=0.622 | P=0.097 |
|FISHER EXACT | P=0.059 (e) | (e) P=0.253 |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 1/49 (2%) 1/50 (2%) 3/50 (6%) |
|ADJUSTED (b) | | 3.0% 6.7% 11.6% |
|TERMINAL (d) | | 0/25 (0%) 1/15 (7%) 1/20 (5%) |
|FIRST INCIDENCE (DAYS) | | 692 735 (T) 537 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.151 P=0.625 P=0.224 |
|INCIDENTAL TUMOR | | P=0.175 P=0.693 P=0.327 |
|LOGISTIC REGRESSION | | P=0.161 P=0.670 P=0.285 |
|COCHRAN-ARMITAGE | | P=0.207 |
|FISHER EXACT | | P=0.747N P=0.316 |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .05 G/KG 0.1 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 1/50 (2%) 0/50 (0%) | 0/49 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 6.8% 2.7% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/41 (2%) 1/37 (3%) 0/36 (0%) | 0/25 (0%) 0/15 (0%) 0/20 (0%) |
|FIRST INCIDENCE (DAYS) | 642 730 (T) --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.079N P=0.344N P=0.152N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.054N P=0.311N P=0.101N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.062N P=0.306N P=0.112N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.060N | (e) |
|FISHER EXACT | P=0.309N P=0.121N | (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 2/50 (4%) | 0/49 (0%) 0/50 (0%) 3/50 (6%) |
|ADJUSTED (b) | 2.4% 2.7% 5.3% | 0.0% 0.0% 11.9% |
|TERMINAL (d) | 1/41 (2%) 1/37 (3%) 1/36 (3%) | 0/25 (0%) 0/15 (0%) 2/20 (10%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 730 (T) 663 | --- --- 372 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.338 P=0.739 P=0.453 | P=0.033 * (e) P=0.096 |
|INCIDENTAL TUMOR | P=0.345 P=0.739 P=0.470 | P=0.041 * (e) P=0.169 |
|LOGISTIC REGRESSION | P=0.355 P=0.739 P=0.486 | P=0.043 * (e) P=0.163 |
|COCHRAN-ARMITAGE | P=0.378 | P=0.038 * |
|FISHER EXACT | P=0.753N P=0.500 | (e) P=0.125 |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .05 G/KG 0.1 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 2/50 (4%) 2/50 (4%) | 0/49 (0%) 0/50 (0%) 3/50 (6%) |
|ADJUSTED (b) | 9.1% 5.4% 5.3% | 0.0% 0.0% 11.9% |
|TERMINAL (d) | 2/41 (5%) 2/37 (5%) 1/36 (3%) | 0/25 (0%) 0/15 (0%) 2/20 (10%) |
|FIRST INCIDENCE (DAYS) | 642 730 (T) 663 | --- --- 372 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.311N P=0.386N P=0.406N | P=0.033 * (e) P=0.096 |
|INCIDENTAL TUMOR | P=0.254N P=0.358N P=0.327N | P=0.041 * (e) P=0.169 |
|LOGISTIC REGRESSION | P=0.269N P=0.353N P=0.337N | P=0.043 * (e) P=0.163 |
|COCHRAN-ARMITAGE | P=0.252N | P=0.038 * |
|FISHER EXACT | P=0.339N P=0.339N | (e) P=0.125 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 0/50 (0%) 4/50 (8%) | 11/49 (22%) 6/50 (12%) 3/50 (6%) |
|ADJUSTED (b) | 13.4% 0.0% 9.8% | 34.7% 27.0% 13.9% |
|TERMINAL (d) | 4/41 (10%) 0/37 (0%) 2/36 (6%) | 7/25 (28%) 1/15 (7%) 2/20 (10%) |
|FIRST INCIDENCE (DAYS) | 544 --- 565 | 502 601 672 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.331N P=0.025N* P=0.444N | P=0.067N P=0.484N P=0.066N |
|INCIDENTAL TUMOR | P=0.196N P=0.023N* P=0.269N | P=0.029N* P=0.200N P=0.023N* |
|LOGISTIC REGRESSION | P=0.235N P=0.012N* P=0.271N | P=0.031N* P=0.220N P=0.039N* |
|COCHRAN-ARMITAGE | P=0.274N | P=0.012N* |
|FISHER EXACT | P=0.013N* P=0.370N | P=0.133N P=0.018N* |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .05 G/KG 0.1 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 0/50 (0%) 4/50 (8%) | 11/49 (22%) 5/50 (10%) 3/50 (6%) |
|ADJUSTED (b) | 13.4% 0.0% 9.8% | 34.7% 22.9% 13.9% |
|TERMINAL (d) | 4/41 (10%) 0/37 (0%) 2/36 (6%) | 7/25 (28%) 1/15 (7%) 2/20 (10%) |
|FIRST INCIDENCE (DAYS) | 544 --- 565 | 502 601 672 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.331N P=0.025N* P=0.444N | P=0.056N P=0.349N P=0.066N |
|INCIDENTAL TUMOR | P=0.196N P=0.023N* P=0.269N | P=0.024N* P=0.124N P=0.023N* |
|LOGISTIC REGRESSION | P=0.235N P=0.012N* P=0.271N | P=0.028N* P=0.137N P=0.039N* |
|COCHRAN-ARMITAGE | P=0.274N | P=0.011N* |
|FISHER EXACT | P=0.013N* P=0.370N | P=0.079N P=0.018N* |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 25/50 (50%) 24/50 (48%) 13/50 (26%) | 11/49 (22%) 13/50 (26%) 15/50 (30%) |
|ADJUSTED (b) | 55.3% 55.3% 34.9% | 36.5% 49.8% 52.7% |
|TERMINAL (d) | 21/41 (51%) 18/37 (49%) 12/36 (33%) | 7/25 (28%) 4/15 (27%) 8/20 (40%) |
|FIRST INCIDENCE (DAYS) | 455 393 632 | 600 538 537 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.043N* P=0.477 P=0.040N* | P=0.071 P=0.070 P=0.087 |
|INCIDENTAL TUMOR | P=0.013N* P=0.572N P=0.018N* | P=0.104 P=0.256 P=0.122 |
|LOGISTIC REGRESSION | P=0.014N* P=0.511N P=0.022N* | P=0.089 P=0.195 P=0.104 |
|COCHRAN-ARMITAGE | P=0.010N** | P=0.230 |
|FISHER EXACT | P=0.500N P=0.011N* | P=0.430 P=0.266 |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .05 G/KG 0.1 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 17/50 (34%) 21/50 (42%) 15/50 (30%) | 15/49 (31%) 6/50 (12%) 9/50 (18%) |
|ADJUSTED (b) | 34.7% 46.3% 32.9% | 47.2% 27.0% 33.5% |
|TERMINAL (d) | 9/41 (22%) 13/37 (35%) 6/36 (17%) | 10/25 (40%) 1/15 (7%) 5/20 (25%) |
|FIRST INCIDENCE (DAYS) | 544 507 509 | 502 601 303 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.513 P=0.196 P=0.571 | P=0.265N P=0.228N P=0.304N |
|INCIDENTAL TUMOR | P=0.218N P=0.298 P=0.237N | P=0.092N P=0.055N P=0.078N |
|LOGISTIC REGRESSION | P=0.139N P=0.378 P=0.141N | P=0.079N P=0.068N P=0.099N |
|COCHRAN-ARMITAGE | P=0.377N | P=0.077N |
|FISHER EXACT | P=0.268 P=0.415N | P=0.021N* P=0.109N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 34/50 (68%) 33/50 (66%) 27/50 (54%) | 24/49 (49%) 18/50 (36%) 19/50 (38%) |
|ADJUSTED (b) | 68.0% 68.7% 58.5% | 71.2% 62.5% 59.9% |
|TERMINAL (d) | 25/41 (61%) 22/37 (59%) 17/36 (47%) | 16/25 (64%) 5/15 (33%) 9/20 (45%) |
|FIRST INCIDENCE (DAYS) | 455 393 509 | 502 538 303 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.348N P=0.423 P=0.364N | P=0.495 P=0.310 P=0.573N |
|INCIDENTAL TUMOR | P=0.052N P=0.472N P=0.075N | P=0.257N P=0.341N P=0.211N |
|LOGISTIC REGRESSION | P=0.037N* P=0.460N P=0.052N | P=0.325N P=0.439N P=0.264N |
|COCHRAN-ARMITAGE | P=0.090N | P=0.158N |
|FISHER EXACT | P=0.500N P=0.109N | P=0.135N P=0.184N |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).