TDMS Study 05053-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
BROMOFORM
NTP Experiment-Test: 05053-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/08/94
Route: GAVAGE Time: 01:01:49
Facility: TSI Mason Research
Chemical CAS #: 75-25-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 01:01:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VF 46 LF 46 HF
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Natural Death 3 6 2
Moribund Sacrifice 13 16 19
Gavage Death 1
Survivors
Terminal Sacrifice 33 28 28
Natural Death 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large (48) (18) (49)
Parasite 5 (10%) 1 (6%) 7 (14%)
Cecum, Inflammation, Acute 1 (2%)
Colon, Fibrosis 1 (2%)
Colon, Necrosis 1 (2%) 1 (6%)
Intestine Small (48) (16) (49)
Lymphoid Nodule, Mineralization 1 (6%)
Liver (50) (49) (50)
Basophilic Focus 28 (56%) 15 (31%) 13 (26%)
Clear Cell Focus 1 (2%)
Cyst 2 (4%)
Eosinophilic Focus 2 (4%) 2 (4%)
Fatty Change, Diffuse 8 (16%) 13 (27%) 20 (40%)
Fatty Change, Focal 11 (22%) 26 (53%) 26 (52%)
Hepatodiaphragmatic Nodule 3 (6%) 2 (4%) 2 (4%)
Hyperplasia, Diffuse 1 (2%)
Hyperplasia, Focal 1 (2%) 1 (2%)
Hyperplasia, Multifocal 1 (2%) 2 (4%) 1 (2%)
Inflammation, Chronic Active 9 (18%) 8 (16%) 27 (54%)
Mixed Cell Focus 8 (16%) 25 (51%) 28 (56%)
Necrosis 11 (22%) 3 (6%) 2 (4%)
Bile Duct, Hyperplasia 17 (34%) 10 (20%) 4 (8%)
Mesentery (4) (3) (3)
Artery, Necrosis, Fibrinoid 1 (33%)
Fat, Inflammation, Chronic Active 1 (33%)
Fat, Necrosis 4 (100%) 2 (67%) 3 (100%)
Pancreas (48) (49) (50)
Acinus, Atrophy 12 (25%) 7 (14%) 3 (6%)
Acinus, Hyperplasia 3 (6%) 2 (4%) 3 (6%)
Artery, Inflammation, Chronic Active 1 (2%)
Artery, Necrosis, Fibrinoid 2 (4%)
Artery, Pigmentation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 01:01:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VF 46 LF 46 HF
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Salivary Glands (49) (49) (50)
Inflammation, Chronic Active 3 (6%)
Acinus, Hyperplasia 1 (2%)
Duct, Ectasia 1 (2%) 8 (16%)
Duct, Inflammation, Chronic Active 9 (18%) 15 (30%)
Duct, Metaplasia, Squamous 10 (20%) 16 (32%)
Stomach (50) (26) (50)
Forestomach, Acanthosis 6 (12%) 7 (27%) 4 (8%)
Forestomach, Hyperkeratosis 7 (14%) 8 (31%) 4 (8%)
Forestomach, Inflammation, Chronic Active 3 (6%) 3 (12%) 2 (4%)
Forestomach, Ulcer 2 (4%) 4 (15%) 1 (2%)
Glandular, Abscess 1 (4%)
Glandular, Hyperplasia, Lymphoid 1 (2%)
Glandular, Inflammation, Chronic Active 1 (4%) 1 (2%)
Glandular, Necrosis 1 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (16) (50)
Cardiomyopathy 34 (68%) 12 (75%) 22 (44%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (18) (50)
Necrosis 1 (2%) 2 (11%)
Cortex, Hyperplasia 1 (2%) 3 (6%)
Medulla, Hyperplasia 4 (8%) 3 (17%) 7 (14%)
Islets, Pancreatic (48) (49) (50)
Ectopic Tissue 1 (2%)
Parathyroid Gland (21) (16) (20)
Hyperplasia 1 (6%)
Pituitary Gland (48) (46) (48)
Pars Distalis, Angiectasis 27 (56%) 11 (24%) 9 (19%)
Pars Distalis, Cyst 6 (13%) 8 (17%) 2 (4%)
Pars Distalis, Hyperplasia 9 (19%) 15 (33%) 7 (15%)
Pars Intermedia, Cyst 1 (2%)
Pars Intermedia, Hyperplasia 2 (4%) 1 (2%)
Thyroid Gland (50) (47) (49)
Necrosis 1 (2%)
C-Cell, Hyperplasia 9 (18%) 7 (15%) 3 (6%)
Follicular Cell, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 01:01:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VF 46 LF 46 HF
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (34) (9) (39)
Inflammation, Chronic Active 2 (6%) 1 (11%) 2 (5%)
Necrosis 2 (6%) 3 (8%)
Ovary (50) (20) (50)
Cyst 5 (10%) 2 (10%) 3 (6%)
Inflammation, Chronic Active 2 (4%)
Mineralization 1 (2%)
Necrosis 1 (5%)
Interstitium, Hyperplasia 1 (2%)
Uterus (49) (50) (50)
Angiectasis 1 (2%)
Decidual Reaction 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (4%)
Mineralization 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (50) (47) (49)
Lumbar, Pigmentation 1 (2%)
Mandibular, Hematopoietic Cell Proliferation 1 (2%)
Mandibular, Infiltration Cellular, Plasma
Cell 1 (2%) 3 (6%)
Mandibular, Pigmentation 1 (2%)
Mediastinal, Congestion 1 (2%)
Mediastinal, Infiltration Cellular, Mast Cell 1 (2%)
Mediastinal, Pigmentation 2 (4%) 2 (4%) 6 (12%)
Mesenteric, Depletion Lymphoid 1 (2%) 2 (4%)
Mesenteric, Infiltration Cellular, Mast Cell 1 (2%)
Mesenteric, Pigmentation 1 (2%)
Pancreatic, Infiltration Cellular, Mast Cell 1 (2%)
Pancreatic, Infiltration Cellular, Plasma
Cell 2 (4%)
Pancreatic, Pigmentation 1 (2%)
Spleen (49) (28) (50)
Depletion Lymphoid 1 (2%) 2 (7%) 2 (4%)
Hematopoietic Cell Proliferation 35 (71%) 17 (61%) 39 (78%)
Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 01:01:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VF 46 LF 46 HF
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Necrosis 1 (2%) 1 (4%)
Pigmentation 7 (14%) 6 (21%) 29 (58%)
Thymus (48) (14) (48)
Infiltration Cellular, Lymphocyte 1 (7%) 1 (2%)
Epithelial Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (44) (42) (39)
Galactocele 25 (57%) 4 (10%) 1 (3%)
Necrosis 1 (2%)
Skin (50) (46) (50)
Hyperkeratosis 1 (2%)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (17) (50)
Brain Stem, Hemorrhage 2 (4%)
Cerebellum, Hemorrhage 2 (4%) 1 (2%)
Cerebellum, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (32) (50)
Infiltration Cellular, Histiocyte 11 (22%) 8 (25%) 16 (32%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 4 (8%) 4 (13%) 4 (8%)
Inflammation, Granulomatous 1 (3%) 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (3%)
Bronchus, Metaplasia, Squamous 1 (2%)
Nose (48) (12) (46)
Hemorrhage 1 (8%)
Inflammation, Chronic Active 2 (17%) 2 (4%)
Metaplasia, Squamous 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic
Active 1 (2%) 1 (2%)
Trachea (50) (47) (50)
Inflammation, Acute 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 01:01:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VF 46 LF 46 HF
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation, Chronic Active 3 (6%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (4)
Inflammation, Acute 1 (25%)
Synechia 1 (25%)
Lens, Cataract 2 (67%) 2 (50%)
Lens, Inflammation, Acute 1 (25%)
Lens, Synechia 2 (67%)
Harderian Gland (1) (4)
Abscess 3 (75%)
Duct, Metaplasia, Squamous 1 (25%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Cyst 1 (2%) 1 (2%)
Necrosis 2 (4%)
Nephropathy 40 (80%) 41 (82%) 46 (92%)
Transitional Epithelium, Hyperplasia 2 (4%) 1 (2%)
Transitional Epithelium, Metaplasia, Osseous 1 (2%)
Transitional Epithelium, Mineralization 1 (2%)
Urinary Bladder (45) (14) (46)
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Mineralization 2 (14%)
Necrosis 1 (2%)
Transitional Epithelium, Hyperplasia 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 01:01:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VM 46 LM 46 HM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Natural Death 9 3 6
Moribund Sacrifice 7 17 33
Survivors
Terminal Sacrifice 34 30 11
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large (50) (50) (50)
Abscess 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Parasite 2 (4%) 5 (10%) 5 (10%)
Cecum, Inflammation, Chronic Active 1 (2%)
Colon, Erosion 1 (2%)
Colon, Hyperplasia, Lymphoid 1 (2%)
Lymphoid Nodule, Hyperplasia 1 (2%) 1 (2%)
Intestine Small (49) (50) (50)
Ileum, Fibrosis 1 (2%)
Ileum, Necrosis 1 (2%)
Liver (50) (50) (50)
Basophilic Focus 28 (56%) 20 (40%) 24 (48%)
Clear Cell Focus 2 (4%)
Degeneration, Cystic 1 (2%)
Eosinophilic Focus 1 (2%) 9 (18%) 4 (8%)
Fatty Change, Diffuse 5 (10%) 13 (26%) 27 (54%)
Fatty Change, Focal 18 (36%) 36 (72%) 23 (46%)
Focal Cellular Change 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%)
Hyperplasia, Focal 2 (4%) 1 (2%)
Hyperplasia, Multifocal 2 (4%) 2 (4%)
Inflammation, Chronic Active 29 (58%) 23 (46%)
Mixed Cell Focus 10 (20%) 11 (22%) 8 (16%)
Necrosis 7 (14%) 3 (6%) 20 (40%)
Bile Duct, Hyperplasia 39 (78%) 37 (74%) 22 (44%)
Mesentery (4) (4) (3)
Artery, Necrosis, Fibrinoid 1 (25%)
Fat, Inflammation, Chronic Active 1 (25%) 1 (25%)
Fat, Necrosis 2 (50%) 3 (75%) 1 (33%)
Pancreas (50) (50) (50)
Acinus, Atrophy 6 (12%) 9 (18%) 3 (6%)
Acinus, Hyperplasia 4 (8%) 2 (4%) 3 (6%)
Artery, Necrosis, Fibrinoid 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 01:01:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VM 46 LM 46 HM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Artery, Thrombosis 1 (2%)
Salivary Glands (50) (50) (48)
Atrophy 1 (2%) 1 (2%)
Atrophy, Focal 1 (2%)
Fibrosis 1 (2%) 1 (2%)
Inflammation, Chronic Active 2 (4%) 3 (6%)
Duct, Ectasia 5 (10%)
Duct, Inflammation, Chronic Active 14 (28%) 22 (46%)
Duct, Metaplasia, Squamous 15 (30%) 31 (65%)
Stomach (49) (50) (50)
Forestomach, Acanthosis 1 (2%) 1 (2%)
Forestomach, Fibrosis 2 (4%)
Forestomach, Hyperkeratosis 6 (12%) 8 (16%) 4 (8%)
Forestomach, Hyperplasia, Basal Cell 3 (6%)
Forestomach, Inflammation, Chronic Active 4 (8%) 4 (8%) 10 (20%)
Forestomach, Necrosis 3 (6%)
Forestomach, Ulcer 1 (2%) 5 (10%) 10 (20%)
Glandular, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Cardiomyopathy 42 (84%) 39 (78%) 23 (46%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (48) (50) (50)
Cyst 2 (4%)
Thrombosis 1 (2%)
Cortex, Hyperplasia 3 (6%) 1 (2%)
Cortex, Hypertrophy, Focal 1 (2%)
Cortex, Necrosis 1 (2%) 1 (2%) 1 (2%)
Medulla, Hyperplasia 21 (44%) 16 (32%) 6 (12%)
Islets, Pancreatic (48) (50) (50)
Hyperplasia 2 (4%) 3 (6%) 2 (4%)
Pituitary Gland (50) (48) (45)
Pars Distalis, Angiectasis 11 (22%) 12 (25%) 1 (2%)
Pars Distalis, Cyst 2 (4%) 2 (4%)
Pars Distalis, Hyperplasia 9 (18%) 26 (54%) 15 (33%)
Pars Intermedia, Hyperplasia 2 (4%)
Pars Nervosa, Cyst 1 (2%) 1 (2%)
Thyroid Gland (49) (49) (47)
Mineralization 1 (2%)
Necrosis 1 (2%)
C-Cell, Hyperplasia 3 (6%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 01:01:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VM 46 LM 46 HM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Capsule, Necrosis, Fibrinoid 1 (2%)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (45) (49) (41)
Inflammation, Chronic Active 1 (2%)
Preputial Gland (41) (38) (34)
Fibrosis 2 (5%)
Inflammation, Chronic Active 7 (17%) 11 (29%) 10 (29%)
Mineralization 1 (2%)
Necrosis 7 (17%) 3 (8%) 7 (21%)
Prostate (49) (46) (50)
Fibrosis 2 (4%) 4 (9%) 5 (10%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 16 (33%) 17 (37%) 19 (38%)
Metaplasia, Squamous 2 (4%) 6 (13%) 12 (24%)
Mineralization 1 (2%) 1 (2%)
Epithelium, Hyperplasia 1 (2%) 2 (4%) 3 (6%)
Seminal Vesicle (50) (48) (50)
Atrophy 1 (2%)
Inflammation 1 (2%)
Testes (50) (50) (50)
Spermatocele 1 (2%) 1 (2%)
Interstitial Cell, Hyperplasia 37 (74%) 39 (78%) 39 (78%)
Seminiferous Tubule, Atrophy 40 (80%) 38 (76%) 33 (66%)
Seminiferous Tubule, Giant Cell 6 (12%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (50) (48) (49)
Lumbar, Pigmentation 1 (2%) 1 (2%)
Mandibular, Infiltration Cellular, Plasma
Cell 4 (8%)
Mandibular, Necrosis 1 (2%)
Mediastinal, Angiectasis 2 (4%) 3 (6%)
Mediastinal, Congestion 1 (2%) 1 (2%)
Mediastinal, Depletion Lymphoid 1 (2%) 1 (2%)
Mediastinal, Hemorrhage 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 01:01:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VM 46 LM 46 HM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Mediastinal, Pigmentation 2 (4%) 12 (24%)
Mesenteric, Angiectasis 1 (2%)
Mesenteric, Infiltration Cellular, Mast Cell 2 (4%)
Pancreatic, Angiectasis 1 (2%)
Pancreatic, Pigmentation 1 (2%)
Spleen (50) (50) (50)
Cyst 1 (2%)
Depletion Lymphoid 4 (8%)
Fibrosis 2 (4%)
Hematopoietic Cell Proliferation 30 (60%) 36 (72%) 35 (70%)
Infarct 1 (2%)
Pigmentation 1 (2%) 2 (4%)
Thymus (47) (46) (41)
Epithelial Cell, Hyperplasia 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (20) (15) (19)
Galactocele 1 (5%)
Skin (49) (49) (50)
Acanthosis 1 (2%)
Cyst 1 (2%)
Cyst Epithelial Inclusion 1 (2%)
Hemorrhage 1 (2%)
Hyperkeratosis 2 (4%) 1 (2%)
Inflammation, Chronic Active 3 (6%)
Necrosis 2 (4%) 2 (4%)
Subcutaneous Tissue, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (49)
Joint, Tarsal, Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Hemorrhage 2 (4%)
Artery, Thrombosis 1 (2%)
Brain Stem, Vacuolization Cytoplasmic 2 (4%)
White Matter, Cerebrum, Vacuolization
Cytoplasmic 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 01:01:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VM 46 LM 46 HM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Bronchiectasis 1 (2%) 1 (2%)
Edema 2 (4%) 3 (6%)
Infiltration Cellular, Histiocyte 8 (16%) 9 (18%) 13 (26%)
Inflammation, Acute 1 (2%) 2 (4%)
Inflammation, Chronic Active 1 (2%) 7 (14%) 15 (30%)
Inflammation, Granulomatous 1 (2%)
Mineralization 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 3 (6%) 6 (12%) 4 (8%)
Bronchiole, Inflammation, Acute 3 (6%)
Bronchus, Metaplasia, Squamous 1 (2%)
Nose (45) (46) (38)
Inflammation, Chronic Active 1 (2%) 3 (7%) 4 (11%)
Metaplasia, Squamous 1 (3%)
Nasolacrimal Duct, Inflammation 1 (3%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3) (2)
Hyperplasia 1 (33%)
Inflammation, Chronic Active 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Cyst 1 (2%) 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Fibrosis, Focal 1 (2%)
Hydronephrosis 1 (2%) 1 (2%)
Necrosis 2 (4%)
Nephropathy 46 (92%) 50 (100%) 45 (90%)
Artery, Necrosis, Fibrinoid 1 (2%)
Pelvis, Inflammation, Acute 1 (2%)
Renal Tubule, Degeneration 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
Urinary Bladder (48) (49) (50)
Hemorrhage 3 (6%) 2 (4%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 2 (4%)
Necrosis 1 (2%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 01:01:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VM 46 LM 46 HM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Transitional Epithelium, Hyperplasia 1 (2%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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