TDMS Study 05053-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) BROMOFORM NTP Experiment-Test: 05053-01 Report: PEIRPT03 Study Type: CHRONIC Date: 09/08/94 Route: GAVAGE Time: 01:01:49 Facility: TSI Mason Research Chemical CAS #: 75-25-2 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 01:01:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VF 46 LF 46 HF ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 Early Deaths Natural Death 3 6 2 Moribund Sacrifice 13 16 19 Gavage Death 1 Survivors Terminal Sacrifice 33 28 28 Natural Death 1 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large (48) (18) (49) Parasite 5 (10%) 1 (6%) 7 (14%) Cecum, Inflammation, Acute 1 (2%) Colon, Fibrosis 1 (2%) Colon, Necrosis 1 (2%) 1 (6%) Intestine Small (48) (16) (49) Lymphoid Nodule, Mineralization 1 (6%) Liver (50) (49) (50) Basophilic Focus 28 (56%) 15 (31%) 13 (26%) Clear Cell Focus 1 (2%) Cyst 2 (4%) Eosinophilic Focus 2 (4%) 2 (4%) Fatty Change, Diffuse 8 (16%) 13 (27%) 20 (40%) Fatty Change, Focal 11 (22%) 26 (53%) 26 (52%) Hepatodiaphragmatic Nodule 3 (6%) 2 (4%) 2 (4%) Hyperplasia, Diffuse 1 (2%) Hyperplasia, Focal 1 (2%) 1 (2%) Hyperplasia, Multifocal 1 (2%) 2 (4%) 1 (2%) Inflammation, Chronic Active 9 (18%) 8 (16%) 27 (54%) Mixed Cell Focus 8 (16%) 25 (51%) 28 (56%) Necrosis 11 (22%) 3 (6%) 2 (4%) Bile Duct, Hyperplasia 17 (34%) 10 (20%) 4 (8%) Mesentery (4) (3) (3) Artery, Necrosis, Fibrinoid 1 (33%) Fat, Inflammation, Chronic Active 1 (33%) Fat, Necrosis 4 (100%) 2 (67%) 3 (100%) Pancreas (48) (49) (50) Acinus, Atrophy 12 (25%) 7 (14%) 3 (6%) Acinus, Hyperplasia 3 (6%) 2 (4%) 3 (6%) Artery, Inflammation, Chronic Active 1 (2%) Artery, Necrosis, Fibrinoid 2 (4%) Artery, Pigmentation 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 01:01:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VF 46 LF 46 HF ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Salivary Glands (49) (49) (50) Inflammation, Chronic Active 3 (6%) Acinus, Hyperplasia 1 (2%) Duct, Ectasia 1 (2%) 8 (16%) Duct, Inflammation, Chronic Active 9 (18%) 15 (30%) Duct, Metaplasia, Squamous 10 (20%) 16 (32%) Stomach (50) (26) (50) Forestomach, Acanthosis 6 (12%) 7 (27%) 4 (8%) Forestomach, Hyperkeratosis 7 (14%) 8 (31%) 4 (8%) Forestomach, Inflammation, Chronic Active 3 (6%) 3 (12%) 2 (4%) Forestomach, Ulcer 2 (4%) 4 (15%) 1 (2%) Glandular, Abscess 1 (4%) Glandular, Hyperplasia, Lymphoid 1 (2%) Glandular, Inflammation, Chronic Active 1 (4%) 1 (2%) Glandular, Necrosis 1 (4%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (16) (50) Cardiomyopathy 34 (68%) 12 (75%) 22 (44%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (50) (18) (50) Necrosis 1 (2%) 2 (11%) Cortex, Hyperplasia 1 (2%) 3 (6%) Medulla, Hyperplasia 4 (8%) 3 (17%) 7 (14%) Islets, Pancreatic (48) (49) (50) Ectopic Tissue 1 (2%) Parathyroid Gland (21) (16) (20) Hyperplasia 1 (6%) Pituitary Gland (48) (46) (48) Pars Distalis, Angiectasis 27 (56%) 11 (24%) 9 (19%) Pars Distalis, Cyst 6 (13%) 8 (17%) 2 (4%) Pars Distalis, Hyperplasia 9 (19%) 15 (33%) 7 (15%) Pars Intermedia, Cyst 1 (2%) Pars Intermedia, Hyperplasia 2 (4%) 1 (2%) Thyroid Gland (50) (47) (49) Necrosis 1 (2%) C-Cell, Hyperplasia 9 (18%) 7 (15%) 3 (6%) Follicular Cell, Cyst 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 01:01:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VF 46 LF 46 HF ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (34) (9) (39) Inflammation, Chronic Active 2 (6%) 1 (11%) 2 (5%) Necrosis 2 (6%) 3 (8%) Ovary (50) (20) (50) Cyst 5 (10%) 2 (10%) 3 (6%) Inflammation, Chronic Active 2 (4%) Mineralization 1 (2%) Necrosis 1 (5%) Interstitium, Hyperplasia 1 (2%) Uterus (49) (50) (50) Angiectasis 1 (2%) Decidual Reaction 1 (2%) Hemorrhage 1 (2%) 1 (2%) Inflammation, Chronic Active 1 (2%) 2 (4%) Mineralization 1 (2%) Necrosis 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (50) (47) (49) Lumbar, Pigmentation 1 (2%) Mandibular, Hematopoietic Cell Proliferation 1 (2%) Mandibular, Infiltration Cellular, Plasma Cell 1 (2%) 3 (6%) Mandibular, Pigmentation 1 (2%) Mediastinal, Congestion 1 (2%) Mediastinal, Infiltration Cellular, Mast Cell 1 (2%) Mediastinal, Pigmentation 2 (4%) 2 (4%) 6 (12%) Mesenteric, Depletion Lymphoid 1 (2%) 2 (4%) Mesenteric, Infiltration Cellular, Mast Cell 1 (2%) Mesenteric, Pigmentation 1 (2%) Pancreatic, Infiltration Cellular, Mast Cell 1 (2%) Pancreatic, Infiltration Cellular, Plasma Cell 2 (4%) Pancreatic, Pigmentation 1 (2%) Spleen (49) (28) (50) Depletion Lymphoid 1 (2%) 2 (7%) 2 (4%) Hematopoietic Cell Proliferation 35 (71%) 17 (61%) 39 (78%) Hemorrhage 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 01:01:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VF 46 LF 46 HF ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Necrosis 1 (2%) 1 (4%) Pigmentation 7 (14%) 6 (21%) 29 (58%) Thymus (48) (14) (48) Infiltration Cellular, Lymphocyte 1 (7%) 1 (2%) Epithelial Cell, Hyperplasia 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (44) (42) (39) Galactocele 25 (57%) 4 (10%) 1 (3%) Necrosis 1 (2%) Skin (50) (46) (50) Hyperkeratosis 1 (2%) Inflammation, Chronic Active 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (17) (50) Brain Stem, Hemorrhage 2 (4%) Cerebellum, Hemorrhage 2 (4%) 1 (2%) Cerebellum, Inflammation, Chronic Active 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (32) (50) Infiltration Cellular, Histiocyte 11 (22%) 8 (25%) 16 (32%) Inflammation, Chronic 1 (2%) Inflammation, Chronic Active 4 (8%) 4 (13%) 4 (8%) Inflammation, Granulomatous 1 (3%) 1 (2%) Alveolar Epithelium, Hyperplasia 1 (2%) 1 (3%) Bronchus, Metaplasia, Squamous 1 (2%) Nose (48) (12) (46) Hemorrhage 1 (8%) Inflammation, Chronic Active 2 (17%) 2 (4%) Metaplasia, Squamous 1 (2%) Nasolacrimal Duct, Inflammation, Chronic Active 1 (2%) 1 (2%) Trachea (50) (47) (50) Inflammation, Acute 2 (4%) a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 01:01:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VF 46 LF 46 HF ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Inflammation, Chronic Active 3 (6%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (3) (4) Inflammation, Acute 1 (25%) Synechia 1 (25%) Lens, Cataract 2 (67%) 2 (50%) Lens, Inflammation, Acute 1 (25%) Lens, Synechia 2 (67%) Harderian Gland (1) (4) Abscess 3 (75%) Duct, Metaplasia, Squamous 1 (25%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) Cyst 1 (2%) 1 (2%) Necrosis 2 (4%) Nephropathy 40 (80%) 41 (82%) 46 (92%) Transitional Epithelium, Hyperplasia 2 (4%) 1 (2%) Transitional Epithelium, Metaplasia, Osseous 1 (2%) Transitional Epithelium, Mineralization 1 (2%) Urinary Bladder (45) (14) (46) Hemorrhage 1 (2%) 1 (2%) Inflammation, Chronic Active 2 (4%) 1 (2%) Mineralization 2 (14%) Necrosis 1 (2%) Transitional Epithelium, Hyperplasia 1 (7%) a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 01:01:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VM 46 LM 46 HM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 Early Deaths Natural Death 9 3 6 Moribund Sacrifice 7 17 33 Survivors Terminal Sacrifice 34 30 11 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large (50) (50) (50) Abscess 1 (2%) Hemorrhage 1 (2%) 1 (2%) Parasite 2 (4%) 5 (10%) 5 (10%) Cecum, Inflammation, Chronic Active 1 (2%) Colon, Erosion 1 (2%) Colon, Hyperplasia, Lymphoid 1 (2%) Lymphoid Nodule, Hyperplasia 1 (2%) 1 (2%) Intestine Small (49) (50) (50) Ileum, Fibrosis 1 (2%) Ileum, Necrosis 1 (2%) Liver (50) (50) (50) Basophilic Focus 28 (56%) 20 (40%) 24 (48%) Clear Cell Focus 2 (4%) Degeneration, Cystic 1 (2%) Eosinophilic Focus 1 (2%) 9 (18%) 4 (8%) Fatty Change, Diffuse 5 (10%) 13 (26%) 27 (54%) Fatty Change, Focal 18 (36%) 36 (72%) 23 (46%) Focal Cellular Change 1 (2%) Hepatodiaphragmatic Nodule 1 (2%) Hyperplasia, Focal 2 (4%) 1 (2%) Hyperplasia, Multifocal 2 (4%) 2 (4%) Inflammation, Chronic Active 29 (58%) 23 (46%) Mixed Cell Focus 10 (20%) 11 (22%) 8 (16%) Necrosis 7 (14%) 3 (6%) 20 (40%) Bile Duct, Hyperplasia 39 (78%) 37 (74%) 22 (44%) Mesentery (4) (4) (3) Artery, Necrosis, Fibrinoid 1 (25%) Fat, Inflammation, Chronic Active 1 (25%) 1 (25%) Fat, Necrosis 2 (50%) 3 (75%) 1 (33%) Pancreas (50) (50) (50) Acinus, Atrophy 6 (12%) 9 (18%) 3 (6%) Acinus, Hyperplasia 4 (8%) 2 (4%) 3 (6%) Artery, Necrosis, Fibrinoid 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 01:01:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VM 46 LM 46 HM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Artery, Thrombosis 1 (2%) Salivary Glands (50) (50) (48) Atrophy 1 (2%) 1 (2%) Atrophy, Focal 1 (2%) Fibrosis 1 (2%) 1 (2%) Inflammation, Chronic Active 2 (4%) 3 (6%) Duct, Ectasia 5 (10%) Duct, Inflammation, Chronic Active 14 (28%) 22 (46%) Duct, Metaplasia, Squamous 15 (30%) 31 (65%) Stomach (49) (50) (50) Forestomach, Acanthosis 1 (2%) 1 (2%) Forestomach, Fibrosis 2 (4%) Forestomach, Hyperkeratosis 6 (12%) 8 (16%) 4 (8%) Forestomach, Hyperplasia, Basal Cell 3 (6%) Forestomach, Inflammation, Chronic Active 4 (8%) 4 (8%) 10 (20%) Forestomach, Necrosis 3 (6%) Forestomach, Ulcer 1 (2%) 5 (10%) 10 (20%) Glandular, Necrosis 1 (2%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) Cardiomyopathy 42 (84%) 39 (78%) 23 (46%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (48) (50) (50) Cyst 2 (4%) Thrombosis 1 (2%) Cortex, Hyperplasia 3 (6%) 1 (2%) Cortex, Hypertrophy, Focal 1 (2%) Cortex, Necrosis 1 (2%) 1 (2%) 1 (2%) Medulla, Hyperplasia 21 (44%) 16 (32%) 6 (12%) Islets, Pancreatic (48) (50) (50) Hyperplasia 2 (4%) 3 (6%) 2 (4%) Pituitary Gland (50) (48) (45) Pars Distalis, Angiectasis 11 (22%) 12 (25%) 1 (2%) Pars Distalis, Cyst 2 (4%) 2 (4%) Pars Distalis, Hyperplasia 9 (18%) 26 (54%) 15 (33%) Pars Intermedia, Hyperplasia 2 (4%) Pars Nervosa, Cyst 1 (2%) 1 (2%) Thyroid Gland (49) (49) (47) Mineralization 1 (2%) Necrosis 1 (2%) C-Cell, Hyperplasia 3 (6%) 3 (6%) a Number of animals examined microscopically at site and number of animals with lesion Page 8 NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 01:01:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VM 46 LM 46 HM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Capsule, Necrosis, Fibrinoid 1 (2%) Follicle, Cyst 1 (2%) Follicular Cell, Hyperplasia 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (45) (49) (41) Inflammation, Chronic Active 1 (2%) Preputial Gland (41) (38) (34) Fibrosis 2 (5%) Inflammation, Chronic Active 7 (17%) 11 (29%) 10 (29%) Mineralization 1 (2%) Necrosis 7 (17%) 3 (8%) 7 (21%) Prostate (49) (46) (50) Fibrosis 2 (4%) 4 (9%) 5 (10%) Inflammation, Acute 1 (2%) Inflammation, Chronic Active 16 (33%) 17 (37%) 19 (38%) Metaplasia, Squamous 2 (4%) 6 (13%) 12 (24%) Mineralization 1 (2%) 1 (2%) Epithelium, Hyperplasia 1 (2%) 2 (4%) 3 (6%) Seminal Vesicle (50) (48) (50) Atrophy 1 (2%) Inflammation 1 (2%) Testes (50) (50) (50) Spermatocele 1 (2%) 1 (2%) Interstitial Cell, Hyperplasia 37 (74%) 39 (78%) 39 (78%) Seminiferous Tubule, Atrophy 40 (80%) 38 (76%) 33 (66%) Seminiferous Tubule, Giant Cell 6 (12%) 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (50) (48) (49) Lumbar, Pigmentation 1 (2%) 1 (2%) Mandibular, Infiltration Cellular, Plasma Cell 4 (8%) Mandibular, Necrosis 1 (2%) Mediastinal, Angiectasis 2 (4%) 3 (6%) Mediastinal, Congestion 1 (2%) 1 (2%) Mediastinal, Depletion Lymphoid 1 (2%) 1 (2%) Mediastinal, Hemorrhage 1 (2%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 9 NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 01:01:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VM 46 LM 46 HM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Mediastinal, Pigmentation 2 (4%) 12 (24%) Mesenteric, Angiectasis 1 (2%) Mesenteric, Infiltration Cellular, Mast Cell 2 (4%) Pancreatic, Angiectasis 1 (2%) Pancreatic, Pigmentation 1 (2%) Spleen (50) (50) (50) Cyst 1 (2%) Depletion Lymphoid 4 (8%) Fibrosis 2 (4%) Hematopoietic Cell Proliferation 30 (60%) 36 (72%) 35 (70%) Infarct 1 (2%) Pigmentation 1 (2%) 2 (4%) Thymus (47) (46) (41) Epithelial Cell, Hyperplasia 2 (4%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (20) (15) (19) Galactocele 1 (5%) Skin (49) (49) (50) Acanthosis 1 (2%) Cyst 1 (2%) Cyst Epithelial Inclusion 1 (2%) Hemorrhage 1 (2%) Hyperkeratosis 2 (4%) 1 (2%) Inflammation, Chronic Active 3 (6%) Necrosis 2 (4%) 2 (4%) Subcutaneous Tissue, Necrosis 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (49) Joint, Tarsal, Hyperostosis 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) Hemorrhage 2 (4%) Artery, Thrombosis 1 (2%) Brain Stem, Vacuolization Cytoplasmic 2 (4%) White Matter, Cerebrum, Vacuolization Cytoplasmic 2 (4%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 10 NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 01:01:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VM 46 LM 46 HM ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) Bronchiectasis 1 (2%) 1 (2%) Edema 2 (4%) 3 (6%) Infiltration Cellular, Histiocyte 8 (16%) 9 (18%) 13 (26%) Inflammation, Acute 1 (2%) 2 (4%) Inflammation, Chronic Active 1 (2%) 7 (14%) 15 (30%) Inflammation, Granulomatous 1 (2%) Mineralization 1 (2%) 1 (2%) Alveolar Epithelium, Hyperplasia 3 (6%) 6 (12%) 4 (8%) Bronchiole, Inflammation, Acute 3 (6%) Bronchus, Metaplasia, Squamous 1 (2%) Nose (45) (46) (38) Inflammation, Chronic Active 1 (2%) 3 (7%) 4 (11%) Metaplasia, Squamous 1 (3%) Nasolacrimal Duct, Inflammation 1 (3%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Harderian Gland (3) (2) Hyperplasia 1 (33%) Inflammation, Chronic Active 1 (50%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) Cyst 1 (2%) 1 (2%) 1 (2%) Fibrosis 1 (2%) Fibrosis, Focal 1 (2%) Hydronephrosis 1 (2%) 1 (2%) Necrosis 2 (4%) Nephropathy 46 (92%) 50 (100%) 45 (90%) Artery, Necrosis, Fibrinoid 1 (2%) Pelvis, Inflammation, Acute 1 (2%) Renal Tubule, Degeneration 1 (2%) Transitional Epithelium, Hyperplasia 1 (2%) Urinary Bladder (48) (49) (50) Hemorrhage 3 (6%) 2 (4%) Inflammation, Chronic Active 1 (2%) 1 (2%) 2 (4%) Necrosis 1 (2%) 3 (6%) a Number of animals examined microscopically at site and number of animals with lesion Page 11 NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 01:01:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VM 46 LM 46 HM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Transitional Epithelium, Hyperplasia 1 (2%) 3 (6%) a Number of animals examined microscopically at site and number of animals with lesion Page 12 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------