TDMS Study 05053-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) BROMOFORM NTP Experiment-Test: 05053-01 Report: PEIRPT05 Study Type: CHRONIC Date: 09/08/94 Route: GAVAGE Time: 01:04:23 Facility: TSI Mason Research Chemical CAS #: 75-25-2 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 01:04:23 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VF 46 LF 46 HF ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 Early Deaths Natural Death 3 6 2 Moribund Sacrifice 13 16 19 Gavage Death 1 Survivors Terminal Sacrifice 33 28 28 Natural Death 1 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large (48) (18) (49) Adenocarcinoma 2 (4%) Polyp Adenomatous 1 (6%) 6 (12%) Intestine Small (48) (16) (49) Liver (50) (49) (50) Neoplastic Nodule 4 (8%) 1 (2%) Neoplastic Nodule, Multiple 1 (2%) Pancreas (48) (49) (50) Acinus, Adenoma 1 (2%) 2 (4%) Acinus, Adenoma, Multiple 1 (2%) Acinus, Carcinoma 1 (2%) Salivary Glands (49) (49) (50) Stomach (50) (26) (50) Forestomach, Squamous Cell Papilloma 1 (2%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (16) (50) Pericardium, Alveolar/Bronchiolar Carcinoma, Metastatic 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (50) (18) (50) Medulla, Pheochromocytoma Benign 2 (4%) 3 (6%) Islets, Pancreatic (48) (49) (50) Adenoma 2 (4%) Pituitary Gland (48) (46) (48) Pars Distalis, Adenoma 26 (54%) 10 (22%) 16 (33%) Page 2 NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 01:04:23 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VF 46 LF 46 HF ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont Pars Distalis, Adenoma, Multiple 3 (6%) 2 (4%) Thyroid Gland (50) (47) (49) C-Cell, Adenoma 4 (8%) 3 (6%) 2 (4%) C-Cell, Carcinoma 1 (2%) Follicular Cell, Adenoma 1 (2%) 1 (2%) 2 (4%) Follicular Cell, Carcinoma 1 (2%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (34) (9) (39) Adenoma 1 (11%) 2 (5%) Carcinoma 1 (3%) 1 (11%) Ovary (50) (20) (50) Granulosa Cell Tumor 1 (5%) 1 (2%) Uterus (49) (50) (50) Leiomyosarcoma 1 (2%) Polyp Stromal 9 (18%) 9 (18%) 2 (4%) Polyp Stromal, Multiple 1 (2%) Sarcoma Stromal 1 (2%) Vagina (2) Squamous Cell Carcinoma 1 (50%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (48) (16) (50) Lymph Node (50) (47) (49) Spleen (49) (28) (50) Thymus (48) (14) (48) Epithelial Cell, Thymoma NOS 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (44) (42) (39) Adenocarcinoma, Multiple 1 (2%) Fibroadenoma 14 (32%) 16 (38%) 6 (15%) Fibroadenoma, Multiple 8 (18%) 1 (2%) Skin (50) (46) (50) Subcutaneous Tissue, Fibrosarcoma 1 (2%) Subcutaneous Tissue, Sarcoma 1 (2%) Page 3 NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 01:04:23 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VF 46 LF 46 HF ____________________________________________________________________________________________________________________________________ ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (17) (50) Astrocytoma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (32) (50) Alveolar/Bronchiolar Adenoma 2 (4%) 1 (3%) 1 (2%) Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%) Carcinoma, Metastatic, Clitoral Gland 1 (3%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) Sarcoma 1 (2%) Pelvis, Transitional Epithelium, Papilloma 1 (2%) Renal Tubule, Adenoma 1 (2%) Urinary Bladder (45) (14) (46) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) Leukemia Mononuclear 9 (18%) 13 (26%) 6 (12%) Lymphoma Malignant Histiocytic 1 (2%) Lymphoma Malignant Lymphocytic 1 (2%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 4 NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 01:04:23 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VF 46 LF 46 HF ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 47 37 38 Total Primary Neoplasms 93 68 60 Total Animals with Benign Neoplasms 41 28 33 Total Benign Neoplasms 74 49 47 Total Animals with Malignant Neoplasms 17 18 10 Total Malignant Neoplasms 18 18 12 Total Animals with Metastatic Neoplasms 1 1 Total Metastatic Neoplasm 1 1 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant 1 1 1 Total Uncertain Neoplasms 1 1 1 ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 5 NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 01:04:23 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VM 46 LM 46 HM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 Early Deaths Natural Death 9 3 6 Moribund Sacrifice 7 17 33 Survivors Terminal Sacrifice 34 30 11 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large (50) (50) (50) Adenocarcinoma 1 (2%) Polyp Adenomatous 2 (4%) Intestine Small (49) (50) (50) Liver (50) (50) (50) Hepatocellular Carcinoma 1 (2%) 1 (2%) Neoplastic Nodule 4 (8%) 2 (4%) Mesentery (4) (4) (3) Pancreas (50) (50) (50) Acinus, Adenoma 1 (2%) 3 (6%) 1 (2%) Salivary Glands (50) (50) (48) Sarcoma 1 (2%) Schwannoma Malignant 1 (2%) Stomach (49) (50) (50) Forestomach, Fibrosarcoma 1 (2%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (48) (50) (50) Bilateral, Medulla, Pheochromocytoma Benign 3 (6%) 1 (2%) 2 (4%) Medulla, Pheochromocytoma Benign 13 (27%) 10 (20%) 6 (12%) Islets, Pancreatic (48) (50) (50) Adenoma 4 (8%) 3 (6%) 1 (2%) Pituitary Gland (50) (48) (45) Pars Distalis, Adenoma 11 (22%) 10 (21%) 1 (2%) Pars Distalis, Adenoma, Multiple 1 (2%) 2 (4%) 1 (2%) Thyroid Gland (49) (49) (47) Page 6 NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 01:04:23 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VM 46 LM 46 HM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont C-Cell, Adenoma 2 (4%) 1 (2%) 3 (6%) C-Cell, Carcinoma 1 (2%) Follicular Cell, Carcinoma 3 (6%) 2 (4%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Tissue NOS (1) Adenoma 1 (100%) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (45) (49) (41) Preputial Gland (41) (38) (34) Adenoma 4 (10%) 3 (8%) Carcinoma 5 (12%) 2 (5%) 1 (3%) Bilateral, Carcinoma 1 (2%) Prostate (49) (46) (50) Seminal Vesicle (50) (48) (50) Testes (50) (50) (50) Bilateral, Interstitial Cell, Adenoma 33 (66%) 41 (82%) 29 (58%) Interstitial Cell, Adenoma 13 (26%) 4 (8%) 8 (16%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (48) Lymph Node (50) (48) (49) Carcinoma, Metastatic, Lung 1 (2%) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Mediastinal, Hepatocellular Carcinoma, Metastatic 1 (2%) Spleen (50) (50) (50) Thymus (47) (46) (41) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (20) (15) (19) Fibroadenoma 4 (20%) Fibroadenoma, Multiple 1 (5%) 1 (7%) Skin (49) (49) (50) Basosquamous Tumor Benign 2 (4%) Keratoacanthoma 1 (2%) Squamous Cell Carcinoma 1 (2%) 1 (2%) Sebaceous Gland, Adenoma 1 (2%) Page 7 NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 01:04:23 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VM 46 LM 46 HM ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont Subcutaneous Tissue, Fibroma 4 (8%) 4 (8%) Subcutaneous Tissue, Fibrosarcoma 1 (2%) Subcutaneous Tissue, Osteosarcoma 1 (2%) Subcutaneous Tissue, Sarcoma 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Skeletal Muscle (2) (1) Hepatocellular Carcinoma, Metastatic 1 (50%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) Astrocytoma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%) Carcinoma 1 (2%) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Hepatocellular Carcinoma, Metastatic 1 (2%) Squamous Cell Carcinoma, Multiple 1 (2%) Nose (45) (46) (38) Carcinoma 1 (2%) Squamous Cell Carcinoma, Metastatic, Skin 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Harderian Gland (3) (2) Adenoma 1 (33%) Zymbal's Gland (1) (2) (1) Carcinoma 1 (100%) 2 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) Renal Tubule, Adenocarcinoma 1 (2%) Renal Tubule, Adenoma 1 (2%) Urinary Bladder (48) (49) (50) Page 8 NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 01:04:23 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VM 46 LM 46 HM ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) Leukemia Mononuclear 14 (28%) 9 (18%) 5 (10%) Lymphoma Malignant Lymphocytic 1 (2%) Mesothelioma Benign 2 (4%) 1 (2%) Mesothelioma Malignant 4 (8%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 9 NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC BROMOFORM Date: 09/08/94 Route: GAVAGE Time: 01:04:23 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE VEHICLE 0.1 G/KG 0.2 G/KG 46 VM 46 LM 46 HM ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 49 49 42 Total Primary Neoplasms 130 112 75 Total Animals with Benign Neoplasms 46 47 38 Total Benign Neoplasms 104 90 55 Total Animals with Malignant Neoplasms 25 21 14 Total Malignant Neoplasms 26 22 20 Total Animals with Metastatic Neoplasms 2 2 Total Metastatic Neoplasm 4 3 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 10 ------------------------------------------------------------ ---------- END OF REPORT ---------- 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