TDMS Study 05053-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
BROMOFORM
NTP Experiment-Test: 05053-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/08/94
Route: GAVAGE Time: 01:04:23
Facility: TSI Mason Research
Chemical CAS #: 75-25-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 01:04:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VF 46 LF 46 HF
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Natural Death 3 6 2
Moribund Sacrifice 13 16 19
Gavage Death 1
Survivors
Terminal Sacrifice 33 28 28
Natural Death 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large (48) (18) (49)
Adenocarcinoma 2 (4%)
Polyp Adenomatous 1 (6%) 6 (12%)
Intestine Small (48) (16) (49)
Liver (50) (49) (50)
Neoplastic Nodule 4 (8%) 1 (2%)
Neoplastic Nodule, Multiple 1 (2%)
Pancreas (48) (49) (50)
Acinus, Adenoma 1 (2%) 2 (4%)
Acinus, Adenoma, Multiple 1 (2%)
Acinus, Carcinoma 1 (2%)
Salivary Glands (49) (49) (50)
Stomach (50) (26) (50)
Forestomach, Squamous Cell Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (16) (50)
Pericardium, Alveolar/Bronchiolar Carcinoma,
Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (18) (50)
Medulla, Pheochromocytoma Benign 2 (4%) 3 (6%)
Islets, Pancreatic (48) (49) (50)
Adenoma 2 (4%)
Pituitary Gland (48) (46) (48)
Pars Distalis, Adenoma 26 (54%) 10 (22%) 16 (33%)
Page 2
NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 01:04:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VF 46 LF 46 HF
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pars Distalis, Adenoma, Multiple 3 (6%) 2 (4%)
Thyroid Gland (50) (47) (49)
C-Cell, Adenoma 4 (8%) 3 (6%) 2 (4%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (2%) 2 (4%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (34) (9) (39)
Adenoma 1 (11%) 2 (5%)
Carcinoma 1 (3%) 1 (11%)
Ovary (50) (20) (50)
Granulosa Cell Tumor 1 (5%) 1 (2%)
Uterus (49) (50) (50)
Leiomyosarcoma 1 (2%)
Polyp Stromal 9 (18%) 9 (18%) 2 (4%)
Polyp Stromal, Multiple 1 (2%)
Sarcoma Stromal 1 (2%)
Vagina (2)
Squamous Cell Carcinoma 1 (50%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (48) (16) (50)
Lymph Node (50) (47) (49)
Spleen (49) (28) (50)
Thymus (48) (14) (48)
Epithelial Cell, Thymoma NOS 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (44) (42) (39)
Adenocarcinoma, Multiple 1 (2%)
Fibroadenoma 14 (32%) 16 (38%) 6 (15%)
Fibroadenoma, Multiple 8 (18%) 1 (2%)
Skin (50) (46) (50)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
Page 3
NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 01:04:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VF 46 LF 46 HF
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (17) (50)
Astrocytoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (32) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 1 (3%) 1 (2%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Carcinoma, Metastatic, Clitoral Gland 1 (3%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Sarcoma 1 (2%)
Pelvis, Transitional Epithelium, Papilloma 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (45) (14) (46)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 9 (18%) 13 (26%) 6 (12%)
Lymphoma Malignant Histiocytic 1 (2%)
Lymphoma Malignant Lymphocytic 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 01:04:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VF 46 LF 46 HF
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 47 37 38
Total Primary Neoplasms 93 68 60
Total Animals with Benign Neoplasms 41 28 33
Total Benign Neoplasms 74 49 47
Total Animals with Malignant Neoplasms 17 18 10
Total Malignant Neoplasms 18 18 12
Total Animals with Metastatic Neoplasms 1 1
Total Metastatic Neoplasm 1 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1 1
Total Uncertain Neoplasms 1 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 5
NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 01:04:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VM 46 LM 46 HM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Natural Death 9 3 6
Moribund Sacrifice 7 17 33
Survivors
Terminal Sacrifice 34 30 11
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large (50) (50) (50)
Adenocarcinoma 1 (2%)
Polyp Adenomatous 2 (4%)
Intestine Small (49) (50) (50)
Liver (50) (50) (50)
Hepatocellular Carcinoma 1 (2%) 1 (2%)
Neoplastic Nodule 4 (8%) 2 (4%)
Mesentery (4) (4) (3)
Pancreas (50) (50) (50)
Acinus, Adenoma 1 (2%) 3 (6%) 1 (2%)
Salivary Glands (50) (50) (48)
Sarcoma 1 (2%)
Schwannoma Malignant 1 (2%)
Stomach (49) (50) (50)
Forestomach, Fibrosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (48) (50) (50)
Bilateral, Medulla, Pheochromocytoma Benign 3 (6%) 1 (2%) 2 (4%)
Medulla, Pheochromocytoma Benign 13 (27%) 10 (20%) 6 (12%)
Islets, Pancreatic (48) (50) (50)
Adenoma 4 (8%) 3 (6%) 1 (2%)
Pituitary Gland (50) (48) (45)
Pars Distalis, Adenoma 11 (22%) 10 (21%) 1 (2%)
Pars Distalis, Adenoma, Multiple 1 (2%) 2 (4%) 1 (2%)
Thyroid Gland (49) (49) (47)
Page 6
NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 01:04:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VM 46 LM 46 HM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
C-Cell, Adenoma 2 (4%) 1 (2%) 3 (6%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Carcinoma 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Adenoma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (45) (49) (41)
Preputial Gland (41) (38) (34)
Adenoma 4 (10%) 3 (8%)
Carcinoma 5 (12%) 2 (5%) 1 (3%)
Bilateral, Carcinoma 1 (2%)
Prostate (49) (46) (50)
Seminal Vesicle (50) (48) (50)
Testes (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 33 (66%) 41 (82%) 29 (58%)
Interstitial Cell, Adenoma 13 (26%) 4 (8%) 8 (16%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (48)
Lymph Node (50) (48) (49)
Carcinoma, Metastatic, Lung 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Mediastinal, Hepatocellular Carcinoma,
Metastatic 1 (2%)
Spleen (50) (50) (50)
Thymus (47) (46) (41)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (20) (15) (19)
Fibroadenoma 4 (20%)
Fibroadenoma, Multiple 1 (5%) 1 (7%)
Skin (49) (49) (50)
Basosquamous Tumor Benign 2 (4%)
Keratoacanthoma 1 (2%)
Squamous Cell Carcinoma 1 (2%) 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Page 7
NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 01:04:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VM 46 LM 46 HM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Subcutaneous Tissue, Fibroma 4 (8%) 4 (8%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Osteosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (2) (1)
Hepatocellular Carcinoma, Metastatic 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Astrocytoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Hepatocellular Carcinoma, Metastatic 1 (2%)
Squamous Cell Carcinoma, Multiple 1 (2%)
Nose (45) (46) (38)
Carcinoma 1 (2%)
Squamous Cell Carcinoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3) (2)
Adenoma 1 (33%)
Zymbal's Gland (1) (2) (1)
Carcinoma 1 (100%) 2 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Renal Tubule, Adenocarcinoma 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (48) (49) (50)
Page 8
NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 01:04:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VM 46 LM 46 HM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 14 (28%) 9 (18%) 5 (10%)
Lymphoma Malignant Lymphocytic 1 (2%)
Mesothelioma Benign 2 (4%) 1 (2%)
Mesothelioma Malignant 4 (8%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 9
NTP Experiment-Test: 05053-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 01:04:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VM 46 LM 46 HM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 49 42
Total Primary Neoplasms 130 112 75
Total Animals with Benign Neoplasms 46 47 38
Total Benign Neoplasms 104 90 55
Total Animals with Malignant Neoplasms 25 21 14
Total Malignant Neoplasms 26 22 20
Total Animals with Metastatic Neoplasms 2 2
Total Metastatic Neoplasm 4 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 10
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