TDMS Study 05053-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason BROMOFORM DATE: 09/08/94
EXPERIMENT: 05053 TEST: 01 TIME: 01:16:50
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01ES2803301 ROUTE: GAVAGE NTP C#: 55130
PATHOLOGIST: K. MURTHY_____ CAS: 75-25-2
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason BROMOFORM DATE: 09/08/94
EXPERIMENT: 05053 TEST: 01 TIME: 01:16:50
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES2803301 ROUTE: GAVAGE NTP C#: 55130
PATHOLOGIST: K. MURTHY_____ CAS: 75-25-2
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason BROMOFORM DATE: 09/08/94
EXPERIMENT: 05053 TEST: 01 TIME: 01:16:50
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES2803301 ROUTE: GAVAGE NTP C#: 55130
PATHOLOGIST: K. MURTHY_____ CAS: 75-25-2
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF BROMOFORM
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Clitoral/Preputial Gland Carcinoma
Carcinoma or Adenoma
Intestine Large Polyp Adenomatous
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Skin: Subcutaneous Tissue Neurofibrosarcoma, Fibrosarcoma, Sarcoma,
Neurofibroma, or Fibroma
Testes Adenoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason BROMOFORM DATE: 09/08/94
EXPERIMENT: 05053 TEST: 01 TIME: 01:16:50
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES2803301 ROUTE: GAVAGE NTP C#: 55130
PATHOLOGIST: K. MURTHY_____ CAS: 75-25-2
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF BROMOFORM
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Clitoral/Preputial Gland Adenoma
Intestine Large Polyp Adenomatous
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Uterus Polyp Stromal
Sarcoma Stromal or Polyp Stromal
All Organs Benign Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.1 G/KG 0.2 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 16/48 (33%) 11/50 (22%) 8/50 (16%) | 2/50 (4%) 0/18 (0%) 3/50 (6%) |
|ADJUSTED (b) | 45.1% 30.0% 49.2% | 5.9% 0.0% 10.0% |
|TERMINAL (d) | 13/32 (41%) 6/30 (20%) 4/11 (36%) | 2/34 (6%) 0/1 (0%) 2/28 (7%) |
|FIRST INCIDENCE (DAYS) | 611 621 643 | 735 (T) --- 721 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.510 P=0.209N P=0.415 | P=0.332 P=0.972N P=0.422 |
|INCIDENTAL TUMOR | P=0.093N P=0.082N P=0.281N | P=0.358 P=0.972N P=0.448 |
|LOGISTIC REGRESSION | P=0.132N P=0.111N P=0.245N | P=0.367 P=0.972N P=0.458 |
|COCHRAN-ARMITAGE | P=0.029N* | P=0.402 |
|FISHER EXACT | P=0.152N P=0.039N* | P=0.538N P=0.500 |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/41 (10%) 3/38 (8%) 0/34 (0%) | 0/34 (0%) 1/9 (11%) 2/39 (5%) |
|ADJUSTED (b) | 13.3% 11.6% 0.0% | 0.0% 100.0% 8.7% |
|TERMINAL (d) | 4/30 (13%) 2/21 (10%) 0/10 (0%) | 0/24 (0%) 1/1 (100%) 2/23 (9%) |
|FIRST INCIDENCE (DAYS) | 734 (T) 632 --- | --- 735 (T) 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.219N P=0.655N P=0.274N | P=0.176 P=0.009 ** P=0.228 |
|INCIDENTAL TUMOR | P=0.187N P=0.647 P=0.274N | P=0.176 P=0.009 ** P=0.228 |
|LOGISTIC REGRESSION | P=0.118N P=0.574N P=0.274N | P=0.176 P=0.009 ** P=0.228 |
|COCHRAN-ARMITAGE | P=0.070N | P=0.205 |
|FISHER EXACT | P=0.543N P=0.083N | P=0.209 P=0.282 |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.1 G/KG 0.2 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/41 (15%) 2/38 (5%) 1/34 (3%) | 1/34 (3%) 1/9 (11%) 0/39 (0%) |
|ADJUSTED (b) | 18.4% 7.5% 7.7% | 2.2% 2.9% 0.0% |
|TERMINAL (d) | 5/30 (17%) 1/21 (5%) 0/10 (0%) | 0/24 (0%) 0/1 (0%) 0/23 (0%) |
|FIRST INCIDENCE (DAYS) | 377 680 716 | 630 638 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.181N P=0.235N P=0.336N | P=0.364N P=0.694 P=0.523N |
|INCIDENTAL TUMOR | P=0.067N P=0.206N P=0.174N | P=0.217N P=0.565N P=0.398N |
|LOGISTIC REGRESSION | P=0.043N* P=0.160N P=0.083N | P=0.272N P=0.757 P=0.420N |
|COCHRAN-ARMITAGE | P=0.046N* | P=0.318N |
|FISHER EXACT | P=0.158N P=0.088N | P=0.379 P=0.466N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/41 (24%) 5/38 (13%) 1/34 (3%) | 1/34 (3%) 2/9 (22%) 2/39 (5%) |
|ADJUSTED (b) | 31.4% 18.7% 7.7% | 2.2% 100.0% 8.7% |
|TERMINAL (d) | 9/30 (30%) 3/21 (14%) 0/10 (0%) | 0/24 (0%) 1/1 (100%) 2/23 (9%) |
|FIRST INCIDENCE (DAYS) | 377 632 716 | 630 638 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.077N P=0.288N P=0.134N | P=0.377 P=0.203 P=0.477 |
|INCIDENTAL TUMOR | P=0.025N* P=0.271N P=0.061N | P=0.439 P=0.463 P=0.549 |
|LOGISTIC REGRESSION | P=0.008N** P=0.163N P=0.014N* | P=0.462 P=0.143 P=0.553 |
|COCHRAN-ARMITAGE | P=0.006N** | P=0.462 |
|FISHER EXACT | P=0.163N P=0.008N** | P=0.106 P=0.552 |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.1 G/KG 0.2 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|Intestine Large |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 8.3% | 0.0% 0.0% 7.1% |
|TERMINAL (d) | 0/34 (0%) 0/30 (0%) 0/11 (0%) | 0/34 (0%) 0/28 (0%) 2/28 (7%) |
|FIRST INCIDENCE (DAYS) | --- --- 723 | --- --- 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.137 (e) P=0.293 | P=0.080 (e) P=0.196 |
|INCIDENTAL TUMOR | P=0.424 (e) P=0.788 | P=0.080 (e) P=0.196 |
|LOGISTIC REGRESSION | P=0.174 (e) P=0.363 | P=0.080 (e) P=0.196 |
|COCHRAN-ARMITAGE | P=0.269 | P=0.095 |
|FISHER EXACT | (e) P=0.500 | (e) P=0.247 |
|=================================================================================================================================|
| |
|Intestine Large |
| Polyp Adenomatous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) | 0/50 (0%) 1/50 (2%) 6/50 (12%) |
|ADJUSTED (b) | 0.0% 0.0% 11.4% | 0.0% 3.6% 17.6% |
|TERMINAL (d) | 0/34 (0%) 0/30 (0%) 1/11 (9%) | 0/34 (0%) 1/28 (4%) 3/28 (11%) |
|FIRST INCIDENCE (DAYS) | --- --- 527 | --- 735 (T) 637 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.042 * (e) P=0.118 | P=0.004 ** P=0.461 P=0.013 * |
|INCIDENTAL TUMOR | P=0.045 * (e) P=0.095 | P=0.005 ** P=0.461 P=0.017 * |
|LOGISTIC REGRESSION | P=0.101 (e) P=0.230 | P=0.004 ** P=0.461 P=0.015 * |
|COCHRAN-ARMITAGE | P=0.095 | P=0.005 ** |
|FISHER EXACT | (e) P=0.247 | P=0.500 P=0.013 * |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.1 G/KG 0.2 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/48 (8%) 3/50 (6%) 1/50 (2%) | 2/48 (4%) 0/49 (0%) 0/50 (0%) |
|ADJUSTED (b) | 12.5% 9.3% 5.3% | 6.1% 0.0% 0.0% |
|TERMINAL (d) | 4/32 (13%) 2/30 (7%) 0/11 (0%) | 2/33 (6%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 734 (T) 679 670 | 735 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.428N P=0.530N P=0.554N | P=0.116N P=0.275N P=0.275N |
|INCIDENTAL TUMOR | P=0.216N P=0.440N P=0.359N | P=0.116N P=0.275N P=0.275N |
|LOGISTIC REGRESSION | P=0.251N P=0.464N P=0.373N | P=0.116N P=0.275N P=0.275N |
|COCHRAN-ARMITAGE | P=0.122N | P=0.091N |
|FISHER EXACT | P=0.477N P=0.168N | P=0.242N P=0.237N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 4/49 (8%) 2/50 (4%) |
|ADJUSTED (b) | 11.0% 5.8% 0.0% | 0.0% 13.8% 7.1% |
|TERMINAL (d) | 3/34 (9%) 1/30 (3%) 0/11 (0%) | 0/34 (0%) 3/28 (11%) 2/28 (7%) |
|FIRST INCIDENCE (DAYS) | 610 659 --- | --- 722 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.122N P=0.362N P=0.220N | P=0.173 P=0.043 * P=0.196 |
|INCIDENTAL TUMOR | P=0.048N* P=0.275N P=0.144N | P=0.192 P=0.033 * P=0.196 |
|LOGISTIC REGRESSION | P=0.054N P=0.320N P=0.109N | P=0.197 P=0.038 * P=0.196 |
|COCHRAN-ARMITAGE | P=0.037N* | P=0.223 |
|FISHER EXACT | P=0.339N P=0.059N | P=0.056 P=0.247 |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.1 G/KG 0.2 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 4/49 (8%) 2/50 (4%) |
|ADJUSTED (b) | 13.5% 5.8% 3.1% | 0.0% 13.8% 7.1% |
|TERMINAL (d) | 3/34 (9%) 1/30 (3%) 0/11 (0%) | 0/34 (0%) 3/28 (11%) 2/28 (7%) |
|FIRST INCIDENCE (DAYS) | 610 659 636 | --- 722 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.194N P=0.239N P=0.343N | P=0.173 P=0.043 * P=0.196 |
|INCIDENTAL TUMOR | P=0.039N* P=0.113N P=0.088N | P=0.192 P=0.033 * P=0.196 |
|LOGISTIC REGRESSION | P=0.082N P=0.204N P=0.161N | P=0.197 P=0.038 * P=0.196 |
|COCHRAN-ARMITAGE | P=0.060N | P=0.223 |
|FISHER EXACT | P=0.218N P=0.102N | P=0.056 P=0.247 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 4/49 (8%) 2/50 (4%) |
|ADJUSTED (b) | 13.5% 5.8% 3.1% | 0.0% 13.8% 7.1% |
|TERMINAL (d) | 3/34 (9%) 1/30 (3%) 0/11 (0%) | 0/34 (0%) 3/28 (11%) 2/28 (7%) |
|FIRST INCIDENCE (DAYS) | 610 659 636 | --- 722 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.194N P=0.239N P=0.343N | P=0.173 P=0.043 * P=0.196 |
|INCIDENTAL TUMOR | P=0.039N* P=0.113N P=0.088N | P=0.192 P=0.033 * P=0.196 |
|LOGISTIC REGRESSION | P=0.082N P=0.204N P=0.161N | P=0.197 P=0.038 * P=0.196 |
|COCHRAN-ARMITAGE | P=0.060N | P=0.223 |
|FISHER EXACT | P=0.218N P=0.102N | P=0.056 P=0.247 |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.1 G/KG 0.2 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 1/50 (2%) | 2/50 (4%) 1/32 (3%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 2.1% 9.1% | 5.6% 2.8% 3.6% |
|TERMINAL (d) | 0/34 (0%) 0/30 (0%) 1/11 (9%) | 1/34 (3%) 0/15 (0%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | --- 600 734 (T) | 691 625 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.212 P=0.531 P=0.276 | P=0.436N P=0.651N P=0.548N |
|INCIDENTAL TUMOR | P=0.309 P=0.531 P=0.276 | P=0.401N P=0.739N P=0.522N |
|LOGISTIC REGRESSION | P=0.310 P=0.448 P=0.276 | P=0.403N P=0.691N P=0.529N |
|COCHRAN-ARMITAGE | P=0.331 | P=0.385N |
|FISHER EXACT | P=0.500 P=0.500 | P=0.664N P=0.500N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 2/50 (4%) | 2/50 (4%) 1/32 (3%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 2.1% 11.5% | 5.6% 2.8% 7.1% |
|TERMINAL (d) | 0/34 (0%) 0/30 (0%) 1/11 (9%) | 1/34 (3%) 0/15 (0%) 2/28 (7%) |
|FIRST INCIDENCE (DAYS) | --- 600 591 | 691 625 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.077 P=0.531 P=0.118 | P=0.541 P=0.651N P=0.638 |
|INCIDENTAL TUMOR | P=0.170 P=0.531 P=0.183 | P=0.573 P=0.739N P=0.660 |
|LOGISTIC REGRESSION | P=0.144 P=0.448 P=0.202 | P=0.577 P=0.691N P=0.665 |
|COCHRAN-ARMITAGE | P=0.142 | P=0.603 |
|FISHER EXACT | P=0.500 P=0.247 | P=0.664N P=0.691N |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.1 G/KG 0.2 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 1/50 (2%) 0/50 (0%) | 22/50 (44%) 17/50 (34%) 6/50 (12%) |
|ADJUSTED (b) | 14.7% 3.3% 0.0% | 50.9% 51.0% 18.2% |
|TERMINAL (d) | 5/34 (15%) 1/30 (3%) 0/11 (0%) | 14/34 (41%) 12/28 (43%) 4/28 (14%) |
|FIRST INCIDENCE (DAYS) | 734 (T) 734 (T) --- | 537 618 543 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.057N P=0.132N P=0.215N | P=0.004N** P=0.509N P=0.004N** |
|INCIDENTAL TUMOR | P=0.057N P=0.132N P=0.215N | P<0.001N** P=0.329N P<0.001N** |
|LOGISTIC REGRESSION | P=0.057N P=0.132N P=0.215N | P<0.001N** P=0.369N P<0.001N** |
|COCHRAN-ARMITAGE | P=0.011N* | P<0.001N** |
|FISHER EXACT | P=0.102N P=0.028N* | P=0.206N P<0.001N** |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 1/50 (2%) 0/50 (0%) | 23/50 (46%) 17/50 (34%) 6/50 (12%) |
|ADJUSTED (b) | 14.7% 3.3% 0.0% | 53.3% 51.0% 18.2% |
|TERMINAL (d) | 5/34 (15%) 1/30 (3%) 0/11 (0%) | 15/34 (44%) 12/28 (43%) 4/28 (14%) |
|FIRST INCIDENCE (DAYS) | 734 (T) 734 (T) --- | 537 618 543 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.057N P=0.132N P=0.215N | P=0.003N** P=0.441N P=0.002N** |
|INCIDENTAL TUMOR | P=0.057N P=0.132N P=0.215N | P<0.001N** P=0.265N P<0.001N** |
|LOGISTIC REGRESSION | P=0.057N P=0.132N P=0.215N | P<0.001N** P=0.303N P<0.001N** |
|COCHRAN-ARMITAGE | P=0.011N* | P<0.001N** |
|FISHER EXACT | P=0.102N P=0.028N* | P=0.154N P<0.001N** |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.1 G/KG 0.2 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|Pancreas |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 1/50 (2%) | 1/48 (2%) 0/49 (0%) 3/50 (6%) |
|ADJUSTED (b) | 2.9% 10.0% 5.0% | 3.0% 0.0% 9.7% |
|TERMINAL (d) | 1/34 (3%) 3/30 (10%) 0/11 (0%) | 1/33 (3%) 0/28 (0%) 2/28 (7%) |
|FIRST INCIDENCE (DAYS) | 734 (T) 734 (T) 666 | 735 (T) --- 665 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.285 P=0.261 P=0.563 | P=0.151 P=0.533N P=0.257 |
|INCIDENTAL TUMOR | P=0.409 P=0.261 P=0.777N | P=0.177 P=0.533N P=0.290 |
|LOGISTIC REGRESSION | P=0.417 P=0.261 P=0.691 | P=0.173 P=0.533N P=0.293 |
|COCHRAN-ARMITAGE | P=0.610N | P=0.185 |
|FISHER EXACT | P=0.309 P=0.753N | P=0.495N P=0.324 |
|=================================================================================================================================|
| |
|Pancreas |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 1/50 (2%) | 1/48 (2%) 1/49 (2%) 3/50 (6%) |
|ADJUSTED (b) | 2.9% 10.0% 5.0% | 3.0% 3.6% 9.7% |
|TERMINAL (d) | 1/34 (3%) 3/30 (10%) 0/11 (0%) | 1/33 (3%) 1/28 (4%) 2/28 (7%) |
|FIRST INCIDENCE (DAYS) | 734 (T) 734 (T) 666 | 735 (T) 735 (T) 665 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.285 P=0.261 P=0.563 | P=0.169 P=0.725 P=0.257 |
|INCIDENTAL TUMOR | P=0.409 P=0.261 P=0.777N | P=0.193 P=0.725 P=0.290 |
|LOGISTIC REGRESSION | P=0.417 P=0.261 P=0.691 | P=0.197 P=0.725 P=0.293 |
|COCHRAN-ARMITAGE | P=0.610N | P=0.212 |
|FISHER EXACT | P=0.309 P=0.753N | P=0.747N P=0.324 |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.1 G/KG 0.2 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/50 (24%) 12/48 (25%) 2/45 (4%) | 29/48 (60%) 12/46 (26%) 16/48 (33%) |
|ADJUSTED (b) | 31.8% 31.9% 11.8% | 66.6% 38.1% 46.9% |
|TERMINAL (d) | 9/34 (26%) 6/28 (21%) 1/11 (9%) | 19/33 (58%) 8/26 (31%) 10/27 (37%) |
|FIRST INCIDENCE (DAYS) | 586 537 616 | 610 538 582 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.149N P=0.508 P=0.130N | P=0.043N* P=0.019N* P=0.067N |
|INCIDENTAL TUMOR | P=0.034N* P=0.543 P=0.044N* | P=0.008N** P=0.003N** P=0.013N* |
|LOGISTIC REGRESSION | P=0.024N* P=0.567 P=0.028N* | P=0.008N** P=0.003N** P=0.012N* |
|COCHRAN-ARMITAGE | P=0.011N* | P=0.005N** |
|FISHER EXACT | P=0.547 P=0.007N** | P<0.001N** P=0.007N** |
|=================================================================================================================================|
| |
|Skin |
| Basosquamous Tumor Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.9% 0.0% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/34 (6%) 0/30 (0%) 0/11 (0%) | 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 734 (T) --- --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.187N P=0.266N P=0.507N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.187N P=0.266N P=0.507N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.187N P=0.266N P=0.507N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.095N | (e) |
|FISHER EXACT | P=0.247N P=0.247N | (e) (e) |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.1 G/KG 0.2 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.4% 3.3% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/34 (3%) 1/30 (3%) 0/11 (0%) | 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 611 734 (T) --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.257N P=0.513N P=0.383N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.185N P=0.511N P=0.249N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.167N P=0.493N P=0.269N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.142N | (e) |
|FISHER EXACT | P=0.500N P=0.247N | (e) (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 4/50 (8%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 10.8% 13.3% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/34 (9%) 4/30 (13%) 0/11 (0%) | 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 514 734 (T) --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.253N P=0.589 P=0.214N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.282N P=0.477 P=0.235N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.103N P=0.620N P=0.084N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.060N | (e) |
|FISHER EXACT | P=0.643N P=0.059N | (e) (e) |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.1 G/KG 0.2 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 5/50 (10%) 0/50 (0%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 13.4% 15.6% 0.0% | 2.9% 3.2% 0.0% |
|TERMINAL (d) | 3/34 (9%) 4/30 (13%) 0/11 (0%) | 1/34 (3%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 514 659 --- | 735 (T) 687 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.195N P=0.582 P=0.158N | P=0.359N P=0.719 P=0.539N |
|INCIDENTAL TUMOR | P=0.097N P=0.637 P=0.066N | P=0.336N P=0.673 P=0.539N |
|LOGISTIC REGRESSION | P=0.061N P=0.609N P=0.049N* | P=0.350N P=0.729 P=0.539N |
|COCHRAN-ARMITAGE | P=0.036N* | P=0.331N |
|FISHER EXACT | P=0.630N P=0.028N* | P=0.753N P=0.500N |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 46/50 (92%) 45/50 (90%) 37/50 (74%) | |
|ADJUSTED (b) | 100.0% 97.8% 100.0% | |
|TERMINAL (d) | 34/34 (100%) 29/30 (97%) 11/11 (100%) | |
|FIRST INCIDENCE (DAYS) | 429 537 499 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.432 P<0.001 ** | |
|INCIDENTAL TUMOR | P=0.529N P=0.379N P=0.555N | |
|LOGISTIC REGRESSION | P=0.234N P=0.134N P=0.251N | |
|COCHRAN-ARMITAGE | P=0.008N** | |
|FISHER EXACT | P=0.500N P=0.016N* | |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.1 G/KG 0.2 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 1/49 (2%) 3/47 (6%) | 4/50 (8%) 3/47 (6%) 2/49 (4%) |
|ADJUSTED (b) | 5.7% 3.3% 13.2% | 11.8% 8.3% 7.1% |
|TERMINAL (d) | 1/34 (3%) 1/30 (3%) 0/9 (0%) | 4/34 (12%) 1/27 (4%) 2/28 (7%) |
|FIRST INCIDENCE (DAYS) | 688 734 (T) 603 | 735 (T) 577 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.152 P=0.532N P=0.209 | P=0.348N P=0.613N P=0.429N |
|INCIDENTAL TUMOR | P=0.548 P=0.392N P=0.576N | P=0.331N P=0.512N P=0.429N |
|LOGISTIC REGRESSION | P=0.303 P=0.488N P=0.383 | P=0.292N P=0.553N P=0.429N |
|COCHRAN-ARMITAGE | P=0.383 | P=0.274N |
|FISHER EXACT | P=0.500N P=0.480 | P=0.535N P=0.349N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 1/49 (2%) 4/47 (9%) | 5/50 (10%) 3/47 (6%) 2/49 (4%) |
|ADJUSTED (b) | 5.7% 3.3% 16.5% | 14.7% 8.3% 7.1% |
|TERMINAL (d) | 1/34 (3%) 1/30 (3%) 0/9 (0%) | 5/34 (15%) 1/27 (4%) 2/28 (7%) |
|FIRST INCIDENCE (DAYS) | 688 734 (T) 603 | 735 (T) 577 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.065 P=0.532N P=0.107 | P=0.230N P=0.479N P=0.298N |
|INCIDENTAL TUMOR | P=0.392 P=0.392N P=0.689N | P=0.214N P=0.381N P=0.298N |
|LOGISTIC REGRESSION | P=0.166 P=0.488N P=0.233 | P=0.185N P=0.421N P=0.298N |
|COCHRAN-ARMITAGE | P=0.224 | P=0.167N |
|FISHER EXACT | P=0.500N P=0.319 | P=0.393N P=0.226N |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.1 G/KG 0.2 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/49 (0%) 0/47 (0%) | 1/50 (2%) 1/47 (2%) 2/49 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 2.9% 3.7% 6.3% |
|TERMINAL (d) | 0/34 (0%) 0/30 (0%) 0/9 (0%) | 1/34 (3%) 1/27 (4%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 735 (T) 735 (T) 713 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.338 P=0.710 P=0.458 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.356 P=0.710 P=0.478 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.354 P=0.710 P=0.470 |
|COCHRAN-ARMITAGE | (e) | P=0.373 |
|FISHER EXACT | (e) (e) | P=0.737 P=0.492 |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 3/49 (6%) 2/47 (4%) | 1/50 (2%) 1/47 (2%) 1/49 (2%) |
|ADJUSTED (b) | 0.0% 9.7% 6.5% | 2.9% 3.7% 2.8% |
|TERMINAL (d) | 0/34 (0%) 2/30 (7%) 0/9 (0%) | 1/34 (3%) 1/27 (4%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- 721 600 | 735 (T) 735 (T) 713 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.054 P=0.103 P=0.188 | P=0.603 P=0.710 P=0.742 |
|INCIDENTAL TUMOR | P=0.222 P=0.169 P=0.418 | P=0.619 P=0.710 P=0.761N |
|LOGISTIC REGRESSION | P=0.134 P=0.114 P=0.229 | P=0.612 P=0.710 P=0.744 |
|COCHRAN-ARMITAGE | P=0.190 | P=0.633 |
|FISHER EXACT | P=0.121 P=0.237 | P=0.737 P=0.747 |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.1 G/KG 0.2 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 3/49 (6%) 2/47 (4%) | 2/50 (4%) 2/47 (4%) 3/49 (6%) |
|ADJUSTED (b) | 0.0% 9.7% 6.5% | 5.9% 7.4% 8.9% |
|TERMINAL (d) | 0/34 (0%) 2/30 (7%) 0/9 (0%) | 2/34 (6%) 2/27 (7%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | --- 721 600 | 735 (T) 735 (T) 713 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.054 P=0.103 P=0.188 | P=0.353 P=0.610 P=0.453 |
|INCIDENTAL TUMOR | P=0.222 P=0.169 P=0.418 | P=0.379 P=0.610 P=0.483 |
|LOGISTIC REGRESSION | P=0.134 P=0.114 P=0.229 | P=0.371 P=0.610 P=0.461 |
|COCHRAN-ARMITAGE | P=0.190 | P=0.398 |
|FISHER EXACT | P=0.121 P=0.237 | P=0.668 P=0.490 |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 10/50 (20%) 9/50 (18%) 2/50 (4%) |
|ADJUSTED (b) | | 26.4% 26.1% 6.2% |
|TERMINAL (d) | | 7/34 (21%) 5/28 (18%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | | 630 538 665 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.040N* P=0.519 P=0.033N* |
|INCIDENTAL TUMOR | | P=0.020N* P=0.594N P=0.023N* |
|LOGISTIC REGRESSION | | P=0.020N* P=0.591N P=0.020N* |
|COCHRAN-ARMITAGE | | P=0.015N* |
|FISHER EXACT | | P=0.500N P=0.014N* |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.1 G/KG 0.2 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 11/50 (22%) 9/50 (18%) 2/50 (4%) |
|ADJUSTED (b) | | 27.9% 26.1% 6.2% |
|TERMINAL (d) | | 7/34 (21%) 5/28 (18%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | | 537 538 665 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.024N* P=0.582N P=0.021N* |
|INCIDENTAL TUMOR | | P=0.008N** P=0.460N P=0.009N** |
|LOGISTIC REGRESSION | | P=0.010N** P=0.458N P=0.009N** |
|COCHRAN-ARMITAGE | | P=0.008N** |
|FISHER EXACT | | P=0.402N P=0.007N** |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.9% 5.7% 2.6% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/34 (3%) 1/30 (3%) 0/11 (0%) | 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 734 (T) 649 527 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.428 P=0.483 P=0.631 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.520 P=0.608 P=0.588 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.614 P=0.515 P=0.770N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.622N | (e) |
|FISHER EXACT | P=0.500 P=0.753N | (e) (e) |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.1 G/KG 0.2 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 14/50 (28%) 9/50 (18%) 5/50 (10%) | 9/50 (18%) 13/50 (26%) 6/50 (12%) |
|ADJUSTED (b) | 34.8% 20.4% 27.8% | 22.8% 32.3% 17.5% |
|TERMINAL (d) | 9/34 (26%) 1/30 (3%) 2/11 (18%) | 5/34 (15%) 3/28 (11%) 3/28 (11%) |
|FIRST INCIDENCE (DAYS) | 483 600 600 | 642 576 483 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.190N P=0.193N P=0.364N | P=0.386N P=0.122 P=0.390N |
|INCIDENTAL TUMOR | P=0.007N** P=0.108N P=0.087N | P=0.237N P=0.179 P=0.266N |
|LOGISTIC REGRESSION | P=0.004N** P=0.086N P=0.048N* | P=0.257N P=0.172 P=0.293N |
|COCHRAN-ARMITAGE | P=0.015N* | P=0.261N |
|FISHER EXACT | P=0.171N P=0.020N* | P=0.235 P=0.288N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) | 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 2.4% | 5.9% 0.0% 0.0% |
|TERMINAL (d) | 0/34 (0%) 0/30 (0%) 0/11 (0%) | 2/34 (6%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 393 | 735 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.246 (e) P=0.469 | P=0.120N P=0.282N P=0.282N |
|INCIDENTAL TUMOR | P=0.233 (e) P=0.419 | P=0.120N P=0.282N P=0.282N |
|LOGISTIC REGRESSION | P=0.430 (e) P=0.666 | P=0.120N P=0.282N P=0.282N |
|COCHRAN-ARMITAGE | P=0.269 | P=0.095N |
|FISHER EXACT | (e) P=0.500 | P=0.247N P=0.247N |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 01 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.1 G/KG 0.2 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) | 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 2.4% | 5.9% 0.0% 0.0% |
|TERMINAL (d) | 0/34 (0%) 0/30 (0%) 0/11 (0%) | 2/34 (6%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 393 | 735 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.246 (e) P=0.469 | P=0.120N P=0.282N P=0.282N |
|INCIDENTAL TUMOR | P=0.233 (e) P=0.419 | P=0.120N P=0.282N P=0.282N |
|LOGISTIC REGRESSION | P=0.430 (e) P=0.666 | P=0.120N P=0.282N P=0.282N |
|COCHRAN-ARMITAGE | P=0.269 | P=0.095N |
|FISHER EXACT | (e) P=0.500 | P=0.247N P=0.247N |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 4/50 (8%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.9% 3.3% 14.4% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/34 (6%) 1/30 (3%) 0/11 (0%) | 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 734 (T) 734 (T) 356 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.076 P=0.544N P=0.121 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.339 P=0.544N P=0.528 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.247 P=0.544N P=0.337 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.238 | (e) |
|FISHER EXACT | P=0.500N P=0.339 | (e) (e) |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 01 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.1 G/KG 0.2 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 46/50 (92%) 47/50 (94%) 38/50 (76%) | 41/50 (82%) 28/50 (56%) 33/50 (66%) |
|ADJUSTED (b) | 100.0% 97.9% 100.0% | 87.1% 72.8% 80.0% |
|TERMINAL (d) | 34/34 (100%) 29/30 (97%) 11/11 (100%) | 28/34 (82%) 18/28 (64%) 20/28 (71%) |
|FIRST INCIDENCE (DAYS) | 429 537 499 | 537 538 543 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.304 P<0.001 ** | P=0.372N P=0.199N P=0.413N |
|INCIDENTAL TUMOR | P=0.549 P=0.636N P=0.592 | P=0.104N P=0.032N* P=0.122N |
|LOGISTIC REGRESSION | P=0.341N P=0.417N P=0.420N | P=0.113N P=0.032N* P=0.131N |
|COCHRAN-ARMITAGE | P=0.012N* | P=0.054N |
|FISHER EXACT | P=0.500 P=0.027N* | P=0.004N** P=0.055N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 25/50 (50%) 21/50 (42%) 14/50 (28%) | 17/50 (34%) 18/50 (36%) 10/50 (20%) |
|ADJUSTED (b) | 55.3% 46.2% 52.1% | 40.4% 44.1% 27.4% |
|TERMINAL (d) | 14/34 (41%) 7/30 (23%) 2/11 (18%) | 10/34 (29%) 6/28 (21%) 5/28 (18%) |
|FIRST INCIDENCE (DAYS) | 377 337 356 | 537 576 319 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.515 P=0.339N P=0.478 | P=0.202N P=0.255 P=0.193N |
|INCIDENTAL TUMOR | P<0.001N** P=0.072N P=0.009N** | P=0.064N P=0.411 P=0.052N |
|LOGISTIC REGRESSION | P=0.005N** P=0.241N P=0.013N* | P=0.069N P=0.459 P=0.062N |
|COCHRAN-ARMITAGE | P=0.016N* | P=0.078N |
|FISHER EXACT | P=0.274N P=0.020N* | P=0.500 P=0.088N |
|=================================================================================================================================|
DATE: 09/08/94 EXPERIMENT: 05053 TEST: 01 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- BROMOFORM
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 0.1 G/KG 0.2 G/KG | VEHICLE 0.1 G/KG 0.2 G/KG |
| | 46 VM 46 LM 46 HM | 46 VF 46 LF 46 HF |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 49/50 (98%) 49/50 (98%) 42/50 (84%) | 47/50 (94%) 37/50 (74%) 38/50 (76%) |
|ADJUSTED (b) | 100.0% 98.0% 100.0% | 94.0% 86.0% 86.0% |
|TERMINAL (d) | 34/34 (100%) 29/30 (97%) 11/11 (100%) | 31/34 (91%) 22/28 (79%) 22/28 (79%) |
|FIRST INCIDENCE (DAYS) | 377 337 356 | 537 538 319 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.389 P<0.001 ** | P=0.376N P=0.479N P=0.401N |
|INCIDENTAL TUMOR | P=0.405N P=0.747N P=0.909 | P=0.026N* P=0.083N P=0.020N* |
|LOGISTIC REGRESSION | P=0.196N P=0.612N P=0.926N | P=0.031N* P=0.073N P=0.023N* |
|COCHRAN-ARMITAGE | P=0.005N** | P=0.015N* |
|FISHER EXACT | P=0.753N P=0.015N* | P=0.006N** P=0.011N* |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).