TDMS Study 05053-01 Pathology Tables
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 Facility: TSI Mason Research Chemical CAS #: 75-25-2 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| DAY ON TEST | 4| 4| 4| 5| 4| 7| 4| 4| 6| 4| 3| 3| 4| 0| 4| 4| 4| 2| 4| 4| 5| 4| 4| 4| 2| | 2| 2| 2| 1| 2| 1| 2| 2| 1| 2| 9| 9| 2| 1| 2| 2| 2| 9| 2| 2| 9| 2| 2| 2| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + A + + + + + + + + + + + + + +| Parasite | 1 | Colon, Fibrosis | 1 | Colon, Necrosis | 3 | __________________________________________________________________________| Intestine Small | + + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X X X X| Fatty Change, Diffuse | 2 2 1 3 2| Fatty Change, Focal | 1 1 2 1 | Hepatodiaphragmatic Nodule | X | Hyperplasia, Multifocal | | Inflammation, Chronic Active | 1 1 1 1 1 | Mixed Cell Focus | X | Necrosis | 1 1 3 1 | Bile Duct, Hyperplasia | 1 1 1 1 1 1 | __________________________________________________________________________| Mesentery | + + | Fat, Necrosis | 3 1 | __________________________________________________________________________| Pancreas | + + + + + + + + + + A + + + + + + + + + + + + + +| Acinus, Atrophy | 1 3 2 1 2 1 | Acinus, Hyperplasia | 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Forestomach, Acanthosis | 1 1 2 2 1| Forestomach, Hyperkeratosis | 1 1 1 2 2 1| Forestomach, Inflammation, Chronic | | Active | 1 1| Forestomach, Ulcer | 2 1| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | | Cortex, Hyperplasia | 2 | Medulla, Hyperplasia | 1 1 1 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + + + M M + M M M + M M M + + + M + + M M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| Pars Distalis, Angiectasis | 1 2 3 3 1 2 3 1 2 1 2 2 3 1 1| Pars Distalis, Cyst | X X X X | Pars Distalis, Hyperplasia | 1 2 1 | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| DAY ON TEST | 4| 4| 4| 5| 4| 7| 4| 4| 6| 4| 3| 3| 4| 0| 4| 4| 4| 2| 4| 4| 5| 4| 4| 4| 2| | 2| 2| 2| 1| 2| 1| 2| 2| 1| 2| 9| 9| 2| 1| 2| 2| 2| 9| 2| 2| 9| 2| 2| 2| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Intermedia, Hyperplasia | 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | M + + + + M + + M + M M + + + + M M + + + + M + +| Inflammation, Chronic Active | 1 | Necrosis | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X X | Inflammation, Chronic Active | 2 | Mineralization | 1 | Interstitium, Hyperplasia | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + M + + + +| Angiectasis | 2 | Hemorrhage | 1 | Inflammation, Chronic Active | 2 | Mineralization | 1 | Necrosis | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mediastinal, Pigmentation | 1 1 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | | Hematopoietic Cell Proliferation | 1 2 1 1 2 1 1 2 3 1 1 1 2 2 1 1 | Hemorrhage | 2 | Necrosis | | Pigmentation | 3 1 2 1 1| __________________________________________________________________________| Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +| Epithelial Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + M + M + + + + + + M M +| Galactocele | X X X X X X X X X X X X X X| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| DAY ON TEST | 4| 4| 4| 5| 4| 7| 4| 4| 6| 4| 3| 3| 4| 0| 4| 4| 4| 2| 4| 4| 5| 4| 4| 4| 2| | 2| 2| 2| 1| 2| 1| 2| 2| 1| 2| 9| 9| 2| 1| 2| 2| 2| 9| 2| 2| 9| 2| 2| 2| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Brain Stem, Hemorrhage | 2 1 | Cerebellum, Hemorrhage | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 1 1 1 1 | Inflammation, Chronic | | Inflammation, Chronic Active | 1 1 1| Alveolar Epithelium, Hyperplasia | | __________________________________________________________________________| Nose | + + + + + + + + M + + + + + + + + + + + + + + + +| Nasolacrimal Duct, Inflammation, | | Chronic Active | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy | 1 1 1 1 1 1 1 2 1 2 2 1 1 1 1 2 2 1 1 3| __________________________________________________________________________| Urinary Bladder | A + + + + + + + + + A + + M M + + + + + + + + + +| Hemorrhage | | Inflammation, Chronic Active | 1 | Necrosis | | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| | DAY ON TEST | 8| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 9| 4| 4| 4| 1| 4| 3| 3| | | 6| 2| 2| 2| 2| 2| 1| 2| 1| 2| 3| 2| 3| 6| 2| 3| 2| 1| 3| 3| 2| 0| 3| 0| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 | Parasite | 2 1 1 1 | 5 1.2| Colon, Fibrosis | | 1 1.0| Colon, Necrosis | | 1 3.0| __________________________________________________________________________|____________| Intestine Small | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X X | 28 | Fatty Change, Diffuse | 2 1 4 | 8 2.1| Fatty Change, Focal | 1 2 2 1 1 1 1 | 11 1.3| Hepatodiaphragmatic Nodule | X X | 3 | Hyperplasia, Multifocal | 2 | 1 2.0| Inflammation, Chronic Active | 3 1 2 1 | 9 1.3| Mixed Cell Focus | X X X X X X X| 8 | Necrosis | 1 2 1 2 1 1 1 | 11 1.4| Bile Duct, Hyperplasia | 1 1 2 1 2 2 1 2 1 1 1 | 17 1.2| __________________________________________________________________________|____________| Mesentery | + + | 4 | Fat, Necrosis | 2 2 | 4 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 | Acinus, Atrophy | 1 2 1 1 1 1 | 12 1.4| Acinus, Hyperplasia | 1 1 | 3 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Forestomach, Acanthosis | 2 | 6 1.5| Forestomach, Hyperkeratosis | 2 | 7 1.4| Forestomach, Inflammation, Chronic | | | Active | 1 | 3 1.0| Forestomach, Ulcer | | 2 1.5| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 | 34 1.1| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis | 1| 1 1.0| Cortex, Hyperplasia | | 1 2.0| Medulla, Hyperplasia | | 4 1.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 5 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| | DAY ON TEST | 8| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 9| 4| 4| 4| 1| 4| 3| 3| | | 6| 2| 2| 2| 2| 2| 1| 2| 1| 2| 3| 2| 3| 6| 2| 3| 2| 1| 3| 3| 2| 0| 3| 0| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Parathyroid Gland | M M M M M M + M M M M M + + + + + + M M M M + M M| 21 | __________________________________________________________________________|____________| Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Pars Distalis, Angiectasis | 1 2 2 2 1 2 2 2 2 2 1 3 | 27 1.9| Pars Distalis, Cyst | X X | 6 | Pars Distalis, Hyperplasia | 2 1 1 2 2 1 | 9 1.4| Pars Intermedia, Hyperplasia | 2 | 2 1.5| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 1 1 1 1 1 1 1 | 9 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + M + + M M M + + M + + + M + + M M + +| 34 | Inflammation, Chronic Active | 2 | 2 1.5| Necrosis | 2 1 | 2 1.5| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X X X| 5 | Inflammation, Chronic Active | 2 | 2 2.0| Mineralization | | 1 1.0| Interstitium, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | | 1 2.0| Hemorrhage | | 1 1.0| Inflammation, Chronic Active | | 1 2.0| Mineralization | | 1 1.0| Necrosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mediastinal, Pigmentation | | 2 1.0| __________________________________________________________________________|____________| Spleen | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | Depletion Lymphoid | 1 | 1 1.0| Hematopoietic Cell Proliferation | 1 1 2 2 2 2 1 1 1 2 2 1 2 1 2 1 2 2 1| 35 1.5| Hemorrhage | | 1 2.0| Necrosis | 2 | 1 2.0| Pigmentation | 2 1 | 7 1.6| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| | DAY ON TEST | 8| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 9| 4| 4| 4| 1| 4| 3| 3| | | 6| 2| 2| 2| 2| 2| 1| 2| 1| 2| 3| 2| 3| 6| 2| 3| 2| 1| 3| 3| 2| 0| 3| 0| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Epithelial Cell, Hyperplasia | | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + M + + + + + + + M + + + + + + + + + +| 44 | Galactocele | X X X X X X X X X X X | 25 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Brain Stem, Hemorrhage | | 2 1.5| Cerebellum, Hemorrhage | 3 | 2 2.5| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Histiocyte | 1 1 1 1 2 1 1| 11 1.1| Inflammation, Chronic | 1 | 1 1.0| Inflammation, Chronic Active | 1 | 4 1.0| Alveolar Epithelium, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Nose | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Nasolacrimal Duct, Inflammation, | | | Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Nephropathy | 1 1 1 1 2 1 1 1 2 2 1 1 1 1 1 2 1 2 2 1 | 40 1.3| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + +| 45 | Hemorrhage | 2 | 1 2.0| Inflammation, Chronic Active | 2 | 2 1.5| Necrosis | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 _____________________________________________________________________________________________________________________ | 2| 7| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 6| 7| 7| 6| 7| 7| 6| 5| DAY ON TEST | 7| 3| 1| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 2| 3| 3| 7| 3| 3| 0| 7| | 9| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 5| 8| 2| 8| 8| 8| 5| 8| 8| 7| 8| 8| 3| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Intestine Large | + + + A + + A +| Parasite | | Colon, Necrosis | | __________________________________________________________________________| Intestine Small | + + + + A + A +| Lymphoid Nodule, Mineralization | 1| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + M + + + + + + + +| Basophilic Focus | X X X X X X X| Cyst | | Eosinophilic Focus | | Fatty Change, Diffuse | 1 2 2 2| Fatty Change, Focal | 1 1 2 1 1 1 1 2 1 1 2 1 1 1 | Hepatodiaphragmatic Nodule | X | Hyperplasia, Focal | | Hyperplasia, Multifocal | 2 | Inflammation, Chronic Active | 1 1 1 1 2 1 | Mixed Cell Focus | X X X X X X X X X X X X X X X | Necrosis | 1 1 1 | Bile Duct, Hyperplasia | 1 2 2 | __________________________________________________________________________| Mesentery | + | Artery, Necrosis, Fibrinoid | | Fat, Inflammation, Chronic Active | | Fat, Necrosis | 2 | __________________________________________________________________________| Pancreas | + + + + + + M + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 1 1 | Acinus, Hyperplasia | 1 | Artery, Inflammation, Chronic Active | | Artery, Necrosis, Fibrinoid | | Artery, Pigmentation | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + M + + + + + + + +| Duct, Ectasia | 1 | Duct, Inflammation, Chronic Active | 1| Duct, Metaplasia, Squamous | 1| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + +| Forestomach, Acanthosis | 2 2 1 1 | Forestomach, Hyperkeratosis | 2 2 1 2 1 1 | Forestomach, Inflammation, Chronic | | Active | 2 1 | Forestomach, Ulcer | 2 1 | Glandular, Abscess | | Glandular, Inflammation, Chronic | | Active | | Glandular, Necrosis | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | _____________________________________________________________________________________________________________________| Page 8 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 _____________________________________________________________________________________________________________________ | 2| 7| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 6| 7| 7| 6| 7| 7| 6| 5| DAY ON TEST | 7| 3| 1| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 2| 3| 3| 7| 3| 3| 0| 7| | 9| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 5| 8| 2| 8| 8| 8| 5| 8| 8| 7| 8| 8| 3| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________| Heart | + + + M + + +| Cardiomyopathy | 1 1 1 1 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + +| Necrosis | 3 1| Medulla, Hyperplasia | 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + M + + + + + + + + + + + + + + + + + +| Ectopic Tissue | X | __________________________________________________________________________| Parathyroid Gland | M M + M + + + M M + + M| Hyperplasia | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + M M + + + + + + + + + + + +| Pars Distalis, Angiectasis | 1 1 2 2 1 2 2 | Pars Distalis, Cyst | X X X X | Pars Distalis, Hyperplasia | 1 1 1 1 1 2 | __________________________________________________________________________| Thyroid Gland | M + + + + + + + + + + + + + + + M + + + + + + + +| Necrosis | 3 | C-Cell, Hyperplasia | | Follicular Cell, Cyst | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | M M M + +| Inflammation, Chronic Active | | __________________________________________________________________________| Ovary | + + + + + + + + +| Cyst | X | Necrosis | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Decidual Reaction | X | __________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + M + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +| Lumbar, Pigmentation | | Mandibular, Infiltration Cellular, | | Plasma Cell | | Mediastinal, Pigmentation | | Mesenteric, Depletion Lymphoid | | Pancreatic, Infiltration Cellular, | | Plasma Cell | | _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 _____________________________________________________________________________________________________________________ | 2| 7| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 6| 7| 7| 6| 7| 7| 6| 5| DAY ON TEST | 7| 3| 1| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 2| 3| 3| 7| 3| 3| 0| 7| | 9| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 5| 8| 2| 8| 8| 8| 5| 8| 8| 7| 8| 8| 3| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Spleen | + + + + + + + + + + + +| Depletion Lymphoid | | Hematopoietic Cell Proliferation | 1 1 2 2 2 2 1 1 | Necrosis | | Pigmentation | 1 3 2 | __________________________________________________________________________| Thymus | M + + M + M +| Infiltration Cellular, Lymphocyte | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + + + + + M + + + + + M + + + M + + + + + + M +| Galactocele | | Necrosis | | __________________________________________________________________________| Skin | + + + + + + + M + + + + + + + + + + + + + + +| Hyperkeratosis | 1 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + M + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + M + + + + + + + +| Infiltration Cellular, Histiocyte | 1 1 1 1 | Inflammation, Chronic Active | 1 1 | Inflammation, Granulomatous | 1 | Alveolar Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Nose | + + + + +| Hemorrhage | | Inflammation, Chronic Active | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + M + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Lens, Cataract | | Lens, Synechia | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | Nephropathy | 4 1 1 1 2 1 1 1 2 1 1 1 1 2 1 2 1 2 1 1| Transitional Epithelium, Hyperplasia | 2 2 | __________________________________________________________________________| Urinary Bladder | + M + A + + +| Mineralization | 1 | Transitional Epithelium, Hyperplasia | 4 | _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 0| 6| 7| 5| 7| 6| 7| 7| 6| 7| 6| 6| 7| 0| 7| 7| 5| 5| 3| | DAY ON TEST | 3| 3| 4| 3| 1| 4| 5| 5| 4| 8| 4| 0| 4| 4| 2| 4| 8| 3| 4| 4| 4| 4| 7| 2| 4| | | 8| 8| 0| 8| 8| 0| 2| 3| 0| 5| 0| 7| 0| 0| 8| 0| 7| 8| 0| 9| 0| 0| 7| 4| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + M + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + +| 18 | Parasite | 1 | 1 1.0| Colon, Necrosis | 1 | 1 1.0| __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + +| 16 | Lymphoid Nodule, Mineralization | | 1 1.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Basophilic Focus | X X X X X X X X | 15 | Cyst | X X | 2 | Eosinophilic Focus | X X | 2 | Fatty Change, Diffuse | 2 2 1 2 2 2 2 2 2 | 13 1.8| Fatty Change, Focal | 1 1 1 1 1 1 2 1 1 1 2 1 | 26 1.2| Hepatodiaphragmatic Nodule | X | 2 | Hyperplasia, Focal | 2 | 1 2.0| Hyperplasia, Multifocal | 2 | 2 2.0| Inflammation, Chronic Active | 1 1 | 8 1.1| Mixed Cell Focus | X X X X X X X X X X | 25 | Necrosis | | 3 1.0| Bile Duct, Hyperplasia | 2 2 1 2 1 1 2 | 10 1.6| __________________________________________________________________________|____________| Mesentery | + + | 3 | Artery, Necrosis, Fibrinoid | 2 | 1 2.0| Fat, Inflammation, Chronic Active | 2 | 1 2.0| Fat, Necrosis | 2 | 2 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acinus, Atrophy | 1 1 1 1 2 | 7 1.1| Acinus, Hyperplasia | 2 | 2 1.5| Artery, Inflammation, Chronic Active | 1 | 1 1.0| Artery, Necrosis, Fibrinoid | 2 1 | 2 1.5| Artery, Pigmentation | 1 | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Duct, Ectasia | | 1 1.0| Duct, Inflammation, Chronic Active | 1 1 2 2 1 2 1 1 | 9 1.3| Duct, Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 | 10 1.0| __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + +| 26 | Forestomach, Acanthosis | 2 1 1 | 7 1.4| Forestomach, Hyperkeratosis | 1 1| 8 1.4| Forestomach, Inflammation, Chronic | | | Active | 2 | 3 1.7| Forestomach, Ulcer | 2 2 | 4 1.8| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 0| 6| 7| 5| 7| 6| 7| 7| 6| 7| 6| 6| 7| 0| 7| 7| 5| 5| 3| | DAY ON TEST | 3| 3| 4| 3| 1| 4| 5| 5| 4| 8| 4| 0| 4| 4| 2| 4| 8| 3| 4| 4| 4| 4| 7| 2| 4| | | 8| 8| 0| 8| 8| 0| 2| 3| 0| 5| 0| 7| 0| 0| 8| 0| 7| 8| 0| 9| 0| 0| 7| 4| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Glandular, Abscess | 2 | 1 2.0| Glandular, Inflammation, Chronic | | | Active | 2 | 1 2.0| Glandular, Necrosis | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + +| 16 | Cardiomyopathy | 1 1 2 1 1 1 1 | 12 1.1| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + M + +| 18 | Necrosis | | 2 2.0| Medulla, Hyperplasia | 1 1 | 3 1.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Ectopic Tissue | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + M + + M M M +| 16 | Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + M +| 46 | Pars Distalis, Angiectasis | 1 1 1 2 | 11 1.5| Pars Distalis, Cyst | X X X X | 8 | Pars Distalis, Hyperplasia | 1 1 1 2 1 1 1 2 2 | 15 1.3| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 47 | Necrosis | | 1 3.0| C-Cell, Hyperplasia | 1 1 1 1 1 1 1 | 7 1.0| Follicular Cell, Cyst | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | M + + + + + + + | 9 | Inflammation, Chronic Active | 1 | 1 1.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + +| 20 | Cyst | X| 2 | Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Decidual Reaction | | 1 | __________________________________________________________________________|____________| Vagina | + | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 0| 6| 7| 5| 7| 6| 7| 7| 6| 7| 6| 6| 7| 0| 7| 7| 5| 5| 3| | DAY ON TEST | 3| 3| 4| 3| 1| 4| 5| 5| 4| 8| 4| 0| 4| 4| 2| 4| 8| 3| 4| 4| 4| 4| 7| 2| 4| | | 8| 8| 0| 8| 8| 0| 2| 3| 0| 5| 0| 7| 0| 0| 8| 0| 7| 8| 0| 9| 0| 0| 7| 4| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + +| 16 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Lumbar, Pigmentation | 2 | 1 2.0| Mandibular, Infiltration Cellular, | | | Plasma Cell | 2 | 1 2.0| Mediastinal, Pigmentation | 2 1 | 2 1.5| Mesenteric, Depletion Lymphoid | 1 | 1 1.0| Pancreatic, Infiltration Cellular, | | | Plasma Cell | 2 2 | 2 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + +| 28 | Depletion Lymphoid | 2 1 | 2 1.5| Hematopoietic Cell Proliferation | 1 1 1 2 2 2 2 1 1 | 17 1.5| Necrosis | 2 | 1 2.0| Pigmentation | 1 2 2| 6 1.8| __________________________________________________________________________|____________| Thymus | + M + + + + + + + + +| 14 | Infiltration Cellular, Lymphocyte | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + M + + + M + + + + + + + + + + + + M + + + + +| 42 | Galactocele | X X X X | 4 | Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Hyperkeratosis | | 1 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + +| 16 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + +| 17 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + +| 32 | Infiltration Cellular, Histiocyte | 1 1 1 1| 8 1.0| Inflammation, Chronic Active | 1 1 | 4 1.0| Inflammation, Granulomatous | | 1 1.0| Alveolar Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + | 12 | Hemorrhage | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 0| 6| 7| 5| 7| 6| 7| 7| 6| 7| 6| 6| 7| 0| 7| 7| 5| 5| 3| | DAY ON TEST | 3| 3| 4| 3| 1| 4| 5| 5| 4| 8| 4| 0| 4| 4| 2| 4| 8| 3| 4| 4| 4| 4| 7| 2| 4| | | 8| 8| 0| 8| 8| 0| 2| 3| 0| 5| 0| 7| 0| 0| 8| 0| 7| 8| 0| 9| 0| 0| 7| 4| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Inflammation, Chronic Active | 2 | 2 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| 47 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + | 3 | Lens, Cataract | X X | 2 | Lens, Synechia | 1 2 | 2 1.5| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 | Nephropathy | 2 2 2 3 2 2 2 2 1 2 1 1 2 1 1 2 2 3 2 3 2| 41 1.7| Transitional Epithelium, Hyperplasia | | 2 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + M + + + + + +| 14 | Mineralization | 1 | 2 1.0| Transitional Epithelium, Hyperplasia | | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 5| 4| 7| 6| 6| 6| 7| 7| 7| 7| 7| 5| 6| 6| 7| DAY ON TEST | 3| 3| 1| 3| 3| 1| 3| 3| 7| 3| 4| 8| 3| 6| 6| 3| 3| 3| 2| 3| 2| 5| 1| 0| 3| | 6| 6| 4| 6| 6| 3| 7| 7| 3| 7| 3| 3| 7| 4| 5| 7| 8| 7| 5| 8| 1| 5| 8| 2| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + A + + + + + + + + + + + + + +| Parasite | 1 1 | Cecum, Inflammation, Acute | 1 | __________________________________________________________________________| Intestine Small | + + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X | Clear Cell Focus | X | Eosinophilic Focus | X | Fatty Change, Diffuse | 2 2 2 2 2 2 2 2 2 2 2 2 3 | Fatty Change, Focal | 1 2 2 2 1 2 1 1 1 1 1| Hepatodiaphragmatic Nodule | X | Hyperplasia, Diffuse | | Hyperplasia, Focal | | Hyperplasia, Multifocal | | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Mixed Cell Focus | X X X X X X X X X X X X X| Necrosis | 2 | Bile Duct, Hyperplasia | 1 1 | __________________________________________________________________________| Mesentery | + + | Fat, Necrosis | 3 1 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 1 1 2 | Acinus, Hyperplasia | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 1 | Acinus, Hyperplasia | | Duct, Ectasia | 1 2 2 | Duct, Inflammation, Chronic Active | 2 1 2 2 2 1 1 1 1 1 | Duct, Metaplasia, Squamous | 2 1 1 2 2 1 2 2 1 1 | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Forestomach, Acanthosis | 1 1 1 | Forestomach, Hyperkeratosis | 2 | Forestomach, Inflammation, Chronic | | Active | 1 | Forestomach, Ulcer | 2 | Glandular, Hyperplasia, Lymphoid | 2 | Glandular, Inflammation, Chronic | | Active | 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 2 1 1 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 5| 4| 7| 6| 6| 6| 7| 7| 7| 7| 7| 5| 6| 6| 7| DAY ON TEST | 3| 3| 1| 3| 3| 1| 3| 3| 7| 3| 4| 8| 3| 6| 6| 3| 3| 3| 2| 3| 2| 5| 1| 0| 3| | 6| 6| 4| 6| 6| 3| 7| 7| 3| 7| 3| 3| 7| 4| 5| 7| 8| 7| 5| 8| 1| 5| 8| 2| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cortex, Hyperplasia | 1 | Medulla, Hyperplasia | 1 1 1 1| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + + M M M M M + M M + M + M M + M + M + + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + M + + + M + + + + + + + + + + + +| Pars Distalis, Angiectasis | 2 2 2| Pars Distalis, Cyst | X X | Pars Distalis, Hyperplasia | 1 2 1 1 | Pars Intermedia, Cyst | X | Pars Intermedia, Hyperplasia | 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + M + + M + + + + + + + M + + +| Inflammation, Chronic Active | | Necrosis | 2 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation, Chronic Active | 1 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Hematopoietic Cell | | Proliferation | | Mandibular, Infiltration Cellular, | | Plasma Cell | | Mandibular, Pigmentation | | Mediastinal, Congestion | | Mediastinal, Infiltration Cellular, | | Mast Cell | | Mediastinal, Pigmentation | 1 | Mesenteric, Depletion Lymphoid | | Mesenteric, Infiltration Cellular, | | Mast Cell | | Mesenteric, Pigmentation | 1 | _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 5| 4| 7| 6| 6| 6| 7| 7| 7| 7| 7| 5| 6| 6| 7| DAY ON TEST | 3| 3| 1| 3| 3| 1| 3| 3| 7| 3| 4| 8| 3| 6| 6| 3| 3| 3| 2| 3| 2| 5| 1| 0| 3| | 6| 6| 4| 6| 6| 3| 7| 7| 3| 7| 3| 3| 7| 4| 5| 7| 8| 7| 5| 8| 1| 5| 8| 2| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Pancreatic, Infiltration Cellular, | | Mast Cell | 1 | Pancreatic, Pigmentation | 1 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | | Hematopoietic Cell Proliferation | 1 2 2 2 1 1 2 2 1 1 1 2 1 1 1 1 1 1 1| Pigmentation | 2 1 1 2 1 2 1 2 1 2 2 1 1 2| __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +| Infiltration Cellular, Lymphocyte | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + M + + + + M + + + M + + + + + + + + + + + +| Galactocele | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Cerebellum, Hemorrhage | 1 | Cerebellum, Inflammation, Chronic | | Active | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 | Inflammation, Chronic Active | | Inflammation, Granulomatous | | Bronchus, Metaplasia, Squamous | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | Metaplasia, Squamous | 1 | Nasolacrimal Duct, Inflammation, | | Chronic Active | 3 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | Inflammation, Chronic Active | 2 2 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Inflammation, Acute | | Synechia | 2 | _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 5| 4| 7| 6| 6| 6| 7| 7| 7| 7| 7| 5| 6| 6| 7| DAY ON TEST | 3| 3| 1| 3| 3| 1| 3| 3| 7| 3| 4| 8| 3| 6| 6| 3| 3| 3| 2| 3| 2| 5| 1| 0| 3| | 6| 6| 4| 6| 6| 3| 7| 7| 3| 7| 3| 3| 7| 4| 5| 7| 8| 7| 5| 8| 1| 5| 8| 2| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Lens, Cataract | X | Lens, Inflammation, Acute | | __________________________________________________________________________| Harderian Gland | + + | Abscess | 2 | Duct, Metaplasia, Squamous | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | Necrosis | 3 | Nephropathy | 2 2 2 2 1 1 1 2 2 2 2 2 2 2 2 1 2 2 1 1 1| Transitional Epithelium, Hyperplasia | 1 | Transitional Epithelium, Metaplasia, | | Osseous | 1 | Transitional Epithelium, | | Mineralization | 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + M M + + + + + + + + + + + + + + + +| Hemorrhage | 1 | Inflammation, Chronic Active | 1 | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 7| 7| 7| 7| 6| 5| 7| | DAY ON TEST | 3| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 6| 3| 3| 1| 3| 2| 4| 8| 3| | | 7| 2| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 3| 8| 8| 3| 8| 2| 0| 2| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite | 1 1 1 1 1 | 7 1.0| Cecum, Inflammation, Acute | | 1 1.0| __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X | 13 | Clear Cell Focus | | 1 | Eosinophilic Focus | X | 2 | Fatty Change, Diffuse | 3 2 2 3 2 2 2 | 20 2.2| Fatty Change, Focal | 1 1 2 1 1 1 1 1 2 1 1 1 2 1 1| 26 1.3| Hepatodiaphragmatic Nodule | X | 2 | Hyperplasia, Diffuse | 3 | 1 3.0| Hyperplasia, Focal | 2 | 1 2.0| Hyperplasia, Multifocal | 2 | 1 2.0| Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 27 1.0| Mixed Cell Focus | X X X X X X X X X X X X X X X| 28 | Necrosis | 1 | 2 1.5| Bile Duct, Hyperplasia | 1 1 | 4 1.0| __________________________________________________________________________|____________| Mesentery | + | 3 | Fat, Necrosis | 2 | 3 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | | 3 1.3| Acinus, Hyperplasia | 1 1 1 | 3 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 | 3 1.0| Acinus, Hyperplasia | 1 | 1 1.0| Duct, Ectasia | 2 1 1 2 1 | 8 1.5| Duct, Inflammation, Chronic Active | 2 1 2 1 2 | 15 1.5| Duct, Metaplasia, Squamous | 2 1 2 1 1 2 | 16 1.5| __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Forestomach, Acanthosis | 2 | 4 1.3| Forestomach, Hyperkeratosis | 2 1 1 | 4 1.5| Forestomach, Inflammation, Chronic | | | Active | 1 | 2 1.0| Forestomach, Ulcer | | 1 2.0| Glandular, Hyperplasia, Lymphoid | | 1 2.0| Glandular, Inflammation, Chronic | | | Active | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 19 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 7| 7| 7| 7| 6| 5| 7| | DAY ON TEST | 3| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 6| 3| 3| 1| 3| 2| 4| 8| 3| | | 7| 2| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 3| 8| 8| 3| 8| 2| 0| 2| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 2 1 2 1 1 1 1 1 1 1 | 22 1.1| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cortex, Hyperplasia | 1 2 | 3 1.3| Medulla, Hyperplasia | 1 1 2 | 7 1.1| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | M M M + + + + + + M M M M + + M M M M M M M M M +| 20 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Pars Distalis, Angiectasis | 2 2 3 2 3 2 | 9 2.2| Pars Distalis, Cyst | | 2 | Pars Distalis, Hyperplasia | 1 1 1 | 7 1.1| Pars Intermedia, Cyst | | 1 | Pars Intermedia, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Hyperplasia | 1 1 | 3 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | M + + + + M M M + + + M + + + + + + + + + + +| 39 | Inflammation, Chronic Active | 1 1 | 2 1.0| Necrosis | 3 | 3 2.3| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X X | 3 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 2 | 1 2.0| Inflammation, Chronic Active | | 2 1.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 | Mandibular, Hematopoietic Cell | | | Proliferation | 1 | 1 1.0| Mandibular, Infiltration Cellular, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 20 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 7| 7| 7| 7| 6| 5| 7| | DAY ON TEST | 3| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 6| 3| 3| 1| 3| 2| 4| 8| 3| | | 7| 2| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 3| 8| 8| 3| 8| 2| 0| 2| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Plasma Cell | 2 2 1 | 3 1.7| Mandibular, Pigmentation | 1 | 1 1.0| Mediastinal, Congestion | 2 | 1 2.0| Mediastinal, Infiltration Cellular, | | | Mast Cell | 1 | 1 1.0| Mediastinal, Pigmentation | 2 2 2 1 2 | 6 1.7| Mesenteric, Depletion Lymphoid | 2 1 | 2 1.5| Mesenteric, Infiltration Cellular, | | | Mast Cell | 1 | 1 1.0| Mesenteric, Pigmentation | | 1 1.0| Pancreatic, Infiltration Cellular, | | | Mast Cell | | 1 1.0| Pancreatic, Pigmentation | | 1 1.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Depletion Lymphoid | 1 1 | 2 1.0| Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 2 1 1 2 2 2 2 1 1 1 2 2 1 | 39 1.3| Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 | 29 1.3| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 | Infiltration Cellular, Lymphocyte | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + + + + M M M + + + M M + M M + + + + + + + + +| 39 | Galactocele | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cerebellum, Hemorrhage | | 1 1.0| Cerebellum, Inflammation, Chronic | | | Active | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Histiocyte | 1 2 1 1 1 1 1 | 16 1.1| Inflammation, Chronic Active | 2 1 1 3 | 4 1.8| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 21 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 7| 7| 7| 7| 6| 5| 7| | DAY ON TEST | 3| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 6| 3| 3| 1| 3| 2| 4| 8| 3| | | 7| 2| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 3| 8| 8| 3| 8| 2| 0| 2| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Inflammation, Granulomatous | 1 | 1 1.0| Bronchus, Metaplasia, Squamous | 2 | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + +| 46 | Inflammation, Chronic Active | 1 | 2 2.0| Metaplasia, Squamous | | 1 1.0| Nasolacrimal Duct, Inflammation, | | | Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Acute | 3 2 | 2 2.5| Inflammation, Chronic Active | 1 | 3 1.7| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 4 | Inflammation, Acute | 3 | 1 3.0| Synechia | | 1 2.0| Lens, Cataract | X | 2 | Lens, Inflammation, Acute | 2 | 1 2.0| __________________________________________________________________________|____________| Harderian Gland | + + | 4 | Abscess | 4 3 | 3 3.0| Duct, Metaplasia, Squamous | | 1 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 | Necrosis | 2 | 2 2.5| Nephropathy | 2 1 1 3 2 1 2 2 1 2 2 3 1 2 2 3 3 2 1 2 2 2 2 1 2| 46 1.8| Transitional Epithelium, Hyperplasia | | 1 1.0| Transitional Epithelium, Metaplasia, | | | Osseous | | 1 1.0| Transitional Epithelium, | | | Mineralization | | 1 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + M + + + + + + + + + + + M +| 46 | Hemorrhage | | 1 1.0| Inflammation, Chronic Active | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 _____________________________________________________________________________________________________________________ | 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| DAY ON TEST | 4| 8| 1| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 1| | 2| 3| 1| 1| 2| 0| 5| 2| 0| 0| 1| 1| 0| 8| 1| 1| 1| 1| 1| 1| 2| 1| 2| 2| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 2 | Hemorrhage | 1 | Parasite | 1 | Cecum, Inflammation, Chronic Active | | Colon, Hyperplasia, Lymphoid | 3 | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X X X | Eosinophilic Focus | | Fatty Change, Diffuse | 1 3 2| Fatty Change, Focal | 1 1 1 1 1 1 1 1 1 2 | Hyperplasia, Focal | | Hyperplasia, Multifocal | 2 | Mixed Cell Focus | X X X | Necrosis | 2 1 1 2 | Bile Duct, Hyperplasia | 2 1 2 2 2 1 1 1 1 1 3 2 1 1 2 2 1 1 2 1 2| __________________________________________________________________________| Mesentery | + | Artery, Necrosis, Fibrinoid | 3 | Fat, Inflammation, Chronic Active | | Fat, Necrosis | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 1 2 | Acinus, Hyperplasia | 1 1 | Artery, Necrosis, Fibrinoid | 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy, Focal | 2 | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Forestomach, Acanthosis | | Forestomach, Hyperkeratosis | 1 1 | Forestomach, Inflammation, Chronic | | Active | 1 1 1 | Forestomach, Necrosis | 1 | Forestomach, Ulcer | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 2 1 2 2 1 1 1 1 2 2 2 2 1 1 1 2 1 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Thrombosis | | Cortex, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| Page 23 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 _____________________________________________________________________________________________________________________ | 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| DAY ON TEST | 4| 8| 1| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 1| | 2| 3| 1| 1| 2| 0| 5| 2| 0| 0| 1| 1| 0| 8| 1| 1| 1| 1| 1| 1| 2| 1| 2| 2| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Cortex, Necrosis | 2 | Medulla, Hyperplasia | 1 1 1 1 1 1 1 1 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + M + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | M M + M + + M + + + + M M M + + + M M M M M M M M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 1 1 2 2 2| Pars Distalis, Cyst | X | Pars Distalis, Hyperplasia | 1 1 1 1 1 | Pars Intermedia, Hyperplasia | 1 | Pars Nervosa, Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 | Capsule, Necrosis, Fibrinoid | 3 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + M + + + + + + + + M + + + + + + + +| Fibrosis | 1 | Inflammation, Chronic Active | 2 2 1 1 | Mineralization | | Necrosis | 2 2 2 2 | __________________________________________________________________________| Prostate | + + + + + + + + + M + + + + + + + + + + + + + + +| Fibrosis | 2 | Inflammation, Acute | | Inflammation, Chronic Active | 1 2 1 1 1 1 2 1 2 | Metaplasia, Squamous | 1 1 | Epithelium, Hyperplasia | 1 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Seminiferous Tubule, Atrophy | 2 1 2 1 1 1 2 1 1 2 1 1 1 2 2 1 1 1 1 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Lumbar, Pigmentation | 2 | Mediastinal, Angiectasis | | Mediastinal, Hemorrhage | 1 | Mediastinal, Pigmentation | 1 | _____________________________________________________________________________________________________________________| Page 24 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 _____________________________________________________________________________________________________________________ | 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| DAY ON TEST | 4| 8| 1| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 1| | 2| 3| 1| 1| 2| 0| 5| 2| 0| 0| 1| 1| 0| 8| 1| 1| 1| 1| 1| 1| 2| 1| 2| 2| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Mesenteric, Angiectasis | | Pancreatic, Angiectasis | 3| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 1 1 1 2 1 1 1 1 3 1 2 1 3 1 1 | Pigmentation | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelial Cell, Hyperplasia | 2 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + M M + M M M + M M M + M + + M M M M + M + M +| Galactocele | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 2 | Cyst Epithelial Inclusion | | Hyperkeratosis | 2 | Necrosis | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Joint, Tarsal, Hyperostosis | | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Bronchiectasis | | Edema | | Infiltration Cellular, Histiocyte | 1 1 2 | Inflammation, Acute | | Inflammation, Chronic Active | | Alveolar Epithelium, Hyperplasia | 2 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hydronephrosis | 1 | _____________________________________________________________________________________________________________________| Page 25 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 _____________________________________________________________________________________________________________________ | 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| DAY ON TEST | 4| 8| 1| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 1| | 2| 3| 1| 1| 2| 0| 5| 2| 0| 0| 1| 1| 0| 8| 1| 1| 1| 1| 1| 1| 2| 1| 2| 2| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Nephropathy | 2 2 2 2 2 1 2 2 3 3 2 2 3 2 2 2 3 2 3 1 3 2 1| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + M| Hemorrhage | 1 | Inflammation, Chronic Active | | Necrosis | 1 | Transitional Epithelium, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 __________________________________________________________________________________________________________________________________ | 7| 5| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 3| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 4| 2| 3| 4| 4| 4| 4| 7| 2| 4| 8| 4| 5| 7| 4| 4| 2| 4| 8| 1| 4| 4| 4| 4| 4| | | 2| 4| 2| 2| 2| 2| 2| 9| 1| 2| 6| 2| 8| 7| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + M| 47 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Abscess | | 1 2.0| Hemorrhage | | 1 1.0| Parasite | 1 | 2 1.0| Cecum, Inflammation, Chronic Active | 3 | 1 3.0| Colon, Hyperplasia, Lymphoid | | 1 3.0| __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X X X| 28 | Eosinophilic Focus | X | 1 | Fatty Change, Diffuse | 2 2 | 5 2.0| Fatty Change, Focal | 1 1 1 2 1 1 1 2| 18 1.2| Hyperplasia, Focal | 2 2 | 2 2.0| Hyperplasia, Multifocal | 2| 2 2.0| Mixed Cell Focus | X X X X X X X | 10 | Necrosis | 2 1 1 | 7 1.4| Bile Duct, Hyperplasia | 1 2 2 2 2 1 1 1 1 2 1 1 1 1 1 2 2 1| 39 1.5| __________________________________________________________________________|____________| Mesentery | + + + | 4 | Artery, Necrosis, Fibrinoid | | 1 3.0| Fat, Inflammation, Chronic Active | 2 | 1 2.0| Fat, Necrosis | 2 1 | 2 1.5| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 1 2 2 1 | 6 1.5| Acinus, Hyperplasia | 1 1 | 4 1.0| Artery, Necrosis, Fibrinoid | | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy, Focal | | 1 2.0| __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | Forestomach, Acanthosis | 3| 1 3.0| Forestomach, Hyperkeratosis | 1 1 2 3| 6 1.5| Forestomach, Inflammation, Chronic | | | Active | 1| 4 1.0| Forestomach, Necrosis | 1 1| 3 1.0| Forestomach, Ulcer | | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 2 2 1 1 2 2 2 2 2 1 1 2 2 1 1 2 1 2 1 1 1| 42 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 27 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 __________________________________________________________________________________________________________________________________ | 7| 5| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 3| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 4| 2| 3| 4| 4| 4| 4| 7| 2| 4| 8| 4| 5| 7| 4| 4| 2| 4| 8| 1| 4| 4| 4| 4| 4| | | 2| 4| 2| 2| 2| 2| 2| 9| 1| 2| 6| 2| 8| 7| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + M + + + + + + + + M| 48 | Thrombosis | 1 | 1 1.0| Cortex, Hyperplasia | 1 1 | 3 1.0| Cortex, Necrosis | | 1 2.0| Medulla, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 | 21 1.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 | Hyperplasia | 1 1 | 2 1.0| __________________________________________________________________________|____________| Parathyroid Gland | M M M + + + + + M + M M M M M + + M M + M M M + M| 20 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Angiectasis | 2 1 2 3 3 2 | 11 1.9| Pars Distalis, Cyst | X | 2 | Pars Distalis, Hyperplasia | 1 2 1 1 | 9 1.1| Pars Intermedia, Hyperplasia | 2 | 2 1.5| Pars Nervosa, Cyst | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | C-Cell, Hyperplasia | 1 | 3 1.0| Capsule, Necrosis, Fibrinoid | | 1 3.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + M + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + M M + + M + + + + +| 41 | Fibrosis | 2 | 2 1.5| Inflammation, Chronic Active | 1 2 2 | 7 1.6| Mineralization | 1 | 1 1.0| Necrosis | 2 2 2 | 7 2.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Fibrosis | 1 | 2 1.5| Inflammation, Acute | 4 | 1 4.0| Inflammation, Chronic Active | 2 2 2 1 2 3 1 | 16 1.6| Metaplasia, Squamous | | 2 1.0| Epithelium, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 28 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 __________________________________________________________________________________________________________________________________ | 7| 5| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 3| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 4| 2| 3| 4| 4| 4| 4| 7| 2| 4| 8| 4| 5| 7| 4| 4| 2| 4| 8| 1| 4| 4| 4| 4| 4| | | 2| 4| 2| 2| 2| 2| 2| 9| 1| 2| 6| 2| 8| 7| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 37 1.0| Seminiferous Tubule, Atrophy | 1 1 1 1 1 1 2 1 2 3 1 1 2 1 1 1 1 1 2 1| 40 1.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lumbar, Pigmentation | | 1 2.0| Mediastinal, Angiectasis | 1 2 | 2 1.5| Mediastinal, Hemorrhage | | 1 1.0| Mediastinal, Pigmentation | 2 | 2 1.5| Mesenteric, Angiectasis | 2 | 1 2.0| Pancreatic, Angiectasis | | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 1 2 1 2 1 2 2 2 1 2 1 1 1 1| 30 1.4| Pigmentation | 1 | 1 1.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + M + + M M + + + + +| 47 | Epithelial Cell, Hyperplasia | | 2 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + M M M M M + M M + + M M M M + M + + + M + + +| 20 | Galactocele | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 | Acanthosis | | 1 2.0| Cyst Epithelial Inclusion | X | 1 | Hyperkeratosis | 2 | 2 2.0| Necrosis | 4 2| 2 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Joint, Tarsal, Hyperostosis | 1 | 1 1.0| __________________________________________________________________________|____________| Skeletal Muscle | + + | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bronchiectasis | 1 | 1 1.0| Edema | 1 1 | 2 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 29 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 __________________________________________________________________________________________________________________________________ | 7| 5| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 3| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 4| 2| 3| 4| 4| 4| 4| 7| 2| 4| 8| 4| 5| 7| 4| 4| 2| 4| 8| 1| 4| 4| 4| 4| 4| | | 2| 4| 2| 2| 2| 2| 2| 9| 1| 2| 6| 2| 8| 7| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Infiltration Cellular, Histiocyte | 1 1 1 2 1 | 8 1.3| Inflammation, Acute | 3 | 1 3.0| Inflammation, Chronic Active | 2 | 1 2.0| Alveolar Epithelium, Hyperplasia | 2 | 3 1.7| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + +| 45 | Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X | 1 | Hydronephrosis | | 1 1.0| Nephropathy | 2 2 1 2 3 1 2 2 1 2 1 1 1 1 2 1 3 1 1 2 3 2 3| 46 1.9| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 | Hemorrhage | 2 3 | 3 2.0| Inflammation, Chronic Active | 2 | 1 2.0| Necrosis | | 1 1.0| Transitional Epithelium, Hyperplasia | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 30 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| DAY ON TEST | 2| 2| 3| 3| 3| 8| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3| 2| 3| 3| | 2| 9| 4| 4| 4| 0| 0| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 6| 5| 0| 9| 6| 1| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + M + + + M M + + + + + + + + M M + + + + + + M +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite | 1 1 1 | Lymphoid Nodule, Hyperplasia | 1 | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X | Clear Cell Focus | X | Degeneration, Cystic | 1| Eosinophilic Focus | X X X X X X X| Fatty Change, Diffuse | 1 2 2 1 3 2 2 2 2 | Fatty Change, Focal | 1 2 1 2 1 1 2 1 1 1 1 2 2 1 1 1| Focal Cellular Change | | Hepatodiaphragmatic Nodule | | Hyperplasia, Focal | 2 | Hyperplasia, Multifocal | 3 2 | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Mixed Cell Focus | X X X X | Necrosis | 2 1 | Bile Duct, Hyperplasia | 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 1 1 | __________________________________________________________________________| Mesentery | + | Fat, Inflammation, Chronic Active | | Fat, Necrosis | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 1 1 2 1| Acinus, Hyperplasia | 1 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | Fibrosis | 2 | Inflammation, Chronic Active | 1 1 | Duct, Ectasia | 2 2 2 1 | Duct, Inflammation, Chronic Active | 1 1 1 2 1 2 1 1 | Duct, Metaplasia, Squamous | 1 1 1 2 1 2 2 1 1 | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Forestomach, Acanthosis | | Forestomach, Fibrosis | 2 | Forestomach, Hyperkeratosis | 1 2 1 2 1 | Forestomach, Inflammation, Chronic | | Active | 1 1 | Forestomach, Ulcer | 2 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 2 1 1 1 1 1 1 2 1 1 1 2 2 1 1| _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| DAY ON TEST | 2| 2| 3| 3| 3| 8| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3| 2| 3| 3| | 2| 9| 4| 4| 4| 0| 0| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 6| 5| 0| 9| 6| 1| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | Cortex, Hyperplasia | 1 | Cortex, Necrosis | 1 | Medulla, Hyperplasia | 1 2 1 1 1 1 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 | __________________________________________________________________________| Parathyroid Gland | + M + + M M + M M + + M M M + M + M M M + + + M M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 3 2 1 1 1 | Pars Distalis, Cyst | X X | Pars Distalis, Hyperplasia | 1 1 1 2 1 1 2 1 2 1 1 1 1 1 1 2 1 | __________________________________________________________________________| Thyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + M + M M + + M M + + + + M +| Inflammation, Chronic Active | 1 1 2 1 1 1| Necrosis | | __________________________________________________________________________| Prostate | + + + M + + + + M M + + + + + + + + + + + + + + +| Fibrosis | 2 2 | Inflammation, Chronic Active | 3 2 1 1 1 1 1 1 3 1 | Metaplasia, Squamous | 2 2 1 | Mineralization | | Epithelium, Hyperplasia | 1 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Spermatocele | | Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Seminiferous Tubule, Atrophy | 1 2 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1| Seminiferous Tubule, Giant Cell | 1 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Infiltration Cellular, | | Plasma Cell | 2 | Mandibular, Necrosis | 1 | _____________________________________________________________________________________________________________________| Page 32 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| DAY ON TEST | 2| 2| 3| 3| 3| 8| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3| 2| 3| 3| | 2| 9| 4| 4| 4| 0| 0| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 6| 5| 0| 9| 6| 1| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Mediastinal, Congestion | | Mediastinal, Depletion Lymphoid | 1 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | Fibrosis | 1 | Hematopoietic Cell Proliferation | 1 1 2 1 3 1 1 2 1 2 1 2 1 1 2 1 1 2 1 1| Pigmentation | 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + M + + + M + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M M + M M M M + M M M M M M M M M + M + M + M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + I + + + + + + + + + +| Cyst | | Hyperkeratosis | 3 | Inflammation, Chronic Active | 1 | Subcutaneous Tissue, Necrosis | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Artery, Thrombosis | 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 1 | Infiltration Cellular, Histiocyte | 1 1 1 1 1| Inflammation, Chronic Active | 1 2 1 2 | Mineralization | 1 | Alveolar Epithelium, Hyperplasia | 2 1 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + + + | Hyperplasia | 2 | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 33 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| DAY ON TEST | 2| 2| 3| 3| 3| 8| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3| 2| 3| 3| | 2| 9| 4| 4| 4| 0| 0| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 6| 5| 0| 9| 6| 1| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Cyst | | Fibrosis, Focal | 2 | Nephropathy | 1 1 2 1 2 1 1 1 1 2 1 1 1 1 2 1 1 2 1 2 2 2 2 2 2| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 3| 7| 5| 6| 6| 7| 7| 7| 7| 7| 6| 6| | DAY ON TEST | 6| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 4| 9| 3| 3| 3| 2| 5| 3| 1| 3| 3| 3| 0| 3| | | 3| 6| 6| 6| 9| 6| 9| 6| 6| 6| 6| 2| 4| 7| 6| 7| 1| 9| 6| 4| 6| 6| 6| 7| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | M + + + + + + + + + + + + + M M + + + M M M M +| 36 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite | 1 1 | 5 1.0| Lymphoid Nodule, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X | 20 | Clear Cell Focus | X | 2 | Degeneration, Cystic | | 1 1.0| Eosinophilic Focus | X X | 9 | Fatty Change, Diffuse | 2 2 2 1 | 13 1.8| Fatty Change, Focal | 2 1 2 1 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1| 36 1.3| Focal Cellular Change | X | 1 | Hepatodiaphragmatic Nodule | X | 1 | Hyperplasia, Focal | | 1 2.0| Hyperplasia, Multifocal | | 2 2.5| Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 29 1.0| Mixed Cell Focus | X X X X X X X | 11 | Necrosis | 1 | 3 1.3| Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2| 37 1.1| __________________________________________________________________________|____________| Mesentery | + + + | 4 | Fat, Inflammation, Chronic Active | 1 | 1 1.0| Fat, Necrosis | 2 2 2 | 3 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 2 1 1 1 1| 9 1.2| Acinus, Hyperplasia | | 2 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 2.0| Fibrosis | | 1 2.0| Inflammation, Chronic Active | | 2 1.0| Duct, Ectasia | 1 | 5 1.6| Duct, Inflammation, Chronic Active | 1 1 2 2 1 1 | 14 1.3| Duct, Metaplasia, Squamous | 1 1 2 2 1 1 | 15 1.3| __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Forestomach, Acanthosis | 3 | 1 3.0| Forestomach, Fibrosis | 1 | 2 1.5| Forestomach, Hyperkeratosis | 1 2 1 | 8 1.4| Forestomach, Inflammation, Chronic | | | Active | 1 4 | 4 1.8| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 35 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 3| 7| 5| 6| 6| 7| 7| 7| 7| 7| 6| 6| | DAY ON TEST | 6| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 4| 9| 3| 3| 3| 2| 5| 3| 1| 3| 3| 3| 0| 3| | | 3| 6| 6| 6| 9| 6| 9| 6| 6| 6| 6| 2| 4| 7| 6| 7| 1| 9| 6| 4| 6| 6| 6| 7| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Forestomach, Ulcer | 2 3 1 | 5 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 2 1 2 2 2 1 1 1 1 2 2 2 2 1 2 2 1 1 1| 39 1.4| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X | 2 | Cortex, Hyperplasia | | 1 1.0| Cortex, Necrosis | | 1 1.0| Medulla, Hyperplasia | 1 2 1 1 1 1 1 1 1 | 16 1.1| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 | 3 1.7| __________________________________________________________________________|____________| Parathyroid Gland | M M + M M M + + M + M + M M M + M M M M + M + + M| 20 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + M + + +| 48 | Pars Distalis, Angiectasis | 1 2 1 3 1 1 1| 12 1.5| Pars Distalis, Cyst | | 2 | Pars Distalis, Hyperplasia | 1 1 1 1 1 1 2 1 1 | 26 1.2| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Hyperplasia | 1 | 3 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Preputial Gland | M M + + + + + M + + M M + + + + + + + + + + + +| 38 | Inflammation, Chronic Active | 1 2 1 1 1 | 11 1.2| Necrosis | 3 3 2 | 3 2.7| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + M + + + + + +| 46 | Fibrosis | 1 1 | 4 1.5| Inflammation, Chronic Active | 1 2 1 2 2 2 2 | 17 1.6| Metaplasia, Squamous | 1 2 1 | 6 1.5| Mineralization | 2 | 1 2.0| Epithelium, Hyperplasia | 1 | 2 1.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Spermatocele | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 36 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 3| 7| 5| 6| 6| 7| 7| 7| 7| 7| 6| 6| | DAY ON TEST | 6| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 4| 9| 3| 3| 3| 2| 5| 3| 1| 3| 3| 3| 0| 3| | | 3| 6| 6| 6| 9| 6| 9| 6| 6| 6| 6| 2| 4| 7| 6| 7| 1| 9| 6| 4| 6| 6| 6| 7| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 39 1.0| Seminiferous Tubule, Atrophy | 2 1 1 1 1 1 1 1 1 1 1 1 3 1 2 2 1 1| 38 1.2| Seminiferous Tubule, Giant Cell | 1 1 1 1| 6 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + + M + + + + M + + + + + + + + + + + + + + + +| 48 | Mandibular, Infiltration Cellular, | | | Plasma Cell | 2 1 1 | 4 1.5| Mandibular, Necrosis | | 1 1.0| Mediastinal, Congestion | 1 | 1 1.0| Mediastinal, Depletion Lymphoid | | 1 1.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 | Fibrosis | 2 | 2 1.5| Hematopoietic Cell Proliferation | 2 1 1 1 2 1 2 1 1 2 1 1 1 1 1 1 | 36 1.3| Pigmentation | 1 | 2 1.5| __________________________________________________________________________|____________| Thymus | + + + + + + + M M + + + + + + + + + + + + + + + +| 46 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M + + M M + + M + + + M M + M M M + M M M| 15 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | X| 1 | Hyperkeratosis | | 1 3.0| Inflammation, Chronic Active | 2 2| 3 1.7| Subcutaneous Tissue, Necrosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 1 2 | 2 1.5| Artery, Thrombosis | | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 2 1 | 3 1.3| Infiltration Cellular, Histiocyte | 1 1 1 1 | 9 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 37 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 3| 7| 5| 6| 6| 7| 7| 7| 7| 7| 6| 6| | DAY ON TEST | 6| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 4| 9| 3| 3| 3| 2| 5| 3| 1| 3| 3| 3| 0| 3| | | 3| 6| 6| 6| 9| 6| 9| 6| 6| 6| 6| 2| 4| 7| 6| 7| 1| 9| 6| 4| 6| 6| 6| 7| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Inflammation, Chronic Active | 2 1 2 | 7 1.6| Mineralization | | 1 1.0| Alveolar Epithelium, Hyperplasia | 2 1 1 | 6 1.3| __________________________________________________________________________|____________| Nose | + M + + + + + + + + M + + + + + + + + + M + + +| 46 | Inflammation, Chronic Active | 1 | 3 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Harderian Gland | | 3 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Zymbal's Gland | + | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X | 1 | Fibrosis, Focal | | 1 2.0| Nephropathy | 1 1 2 3 1 1 1 2 2 2 2 2 1 1 2 1 1 1 2 2 3 2 3 1 1| 50 1.5| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 6| 2| 6| 6| 3| 3| 6| 2| 5| 6| 6| 5| 6| 6| 6| 3| 7| 7| 2| 7| 6| DAY ON TEST | 3| 3| 4| 4| 4| 9| 6| 6| 0| 0| 7| 3| 9| 3| 1| 2| 4| 4| 4| 5| 3| 1| 7| 3| 7| | 4| 4| 2| 9| 3| 9| 6| 4| 3| 3| 2| 6| 1| 8| 6| 7| 4| 2| 9| 6| 4| 5| 5| 4| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + M + + M M + M + + + + + + + + + + M M +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Parasite | 1 | Colon, Erosion | 2 | Lymphoid Nodule, Hyperplasia | 1 | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| Ileum, Fibrosis | 1 | Ileum, Necrosis | 2 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X| Eosinophilic Focus | X X | Fatty Change, Diffuse | 2 2 2 2 3 3 3 3 2 2 3 3 2 3 3| Fatty Change, Focal | 2 1 1 1 2 2 1 1 2 1 | Inflammation, Chronic Active | 1 2 1 2 2 1 2 1 1 1 1 1 1 1 1| Mixed Cell Focus | X X X | Necrosis | 1 1 1 1 1 2 1 1 | Bile Duct, Hyperplasia | 1 1 2 1 2 1 1 2 2| __________________________________________________________________________| Mesentery | + +| Fat, Necrosis | 1| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 1 | Acinus, Hyperplasia | 1 | Artery, Thrombosis | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Fibrosis | 1 | Inflammation, Chronic Active | 1 1 | Duct, Inflammation, Chronic Active | 1 1 1 2 2 1 2 2 1 1 2 1| Duct, Metaplasia, Squamous | 2 2 1 1 1 1 1 2 2 1 2 3 1 1 2 2| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Forestomach, Hyperkeratosis | 2 1 | Forestomach, Hyperplasia, Basal Cell | 1 2 2 | Forestomach, Inflammation, Chronic | | Active | 1 1 2 2 1 2| Forestomach, Ulcer | 2 2 2 2 2 1 2| Glandular, Necrosis | 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 39 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 6| 2| 6| 6| 3| 3| 6| 2| 5| 6| 6| 5| 6| 6| 6| 3| 7| 7| 2| 7| 6| DAY ON TEST | 3| 3| 4| 4| 4| 9| 6| 6| 0| 0| 7| 3| 9| 3| 1| 2| 4| 4| 4| 5| 3| 1| 7| 3| 7| | 4| 4| 2| 9| 3| 9| 6| 4| 3| 3| 2| 6| 1| 8| 6| 7| 4| 2| 9| 6| 4| 5| 5| 4| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Cortex, Hypertrophy, Focal | 1 | Cortex, Necrosis | | Medulla, Hyperplasia | 1 1 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Parathyroid Gland | M + M M M M M M M M + M + M + M M + M + M M M M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| Pars Distalis, Angiectasis | 1 | Pars Distalis, Hyperplasia | 1 2 1 1 1 2 1 2 | Pars Nervosa, Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 | Necrosis | 1 | Follicle, Cyst | | Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + M + + M M + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + M + + + + + +| Inflammation, Chronic Active | 1 2 1 1 1 | Necrosis | 1 2 1 2 1 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 1 1 1 1 | Inflammation, Chronic Active | 1 1 2 2 1 4 1 1 3 1 2 1 2 1| Metaplasia, Squamous | 1 1 2 1 1 2 1 3 1 | Mineralization | | Epithelium, Hyperplasia | 1 1 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Spermatocele | | Interstitial Cell, Hyperplasia | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1| Seminiferous Tubule, Atrophy | 1 1 1 1 1 1 3 2 1 1 1 1 1 1| Seminiferous Tubule, Giant Cell | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + M + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Lumbar, Pigmentation | | Mediastinal, Angiectasis | 1| _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 6| 2| 6| 6| 3| 3| 6| 2| 5| 6| 6| 5| 6| 6| 6| 3| 7| 7| 2| 7| 6| DAY ON TEST | 3| 3| 4| 4| 4| 9| 6| 6| 0| 0| 7| 3| 9| 3| 1| 2| 4| 4| 4| 5| 3| 1| 7| 3| 7| | 4| 4| 2| 9| 3| 9| 6| 4| 3| 3| 2| 6| 1| 8| 6| 7| 4| 2| 9| 6| 4| 5| 5| 4| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Mediastinal, Congestion | 1 | Mediastinal, Depletion Lymphoid | 1 | Mediastinal, Hemorrhage | | Mediastinal, Pigmentation | 2 2 2 1 1 1| Mesenteric, Infiltration Cellular, | | Mast Cell | 1 1 | Pancreatic, Pigmentation | 1 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | 1 1 1 | Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 2 2 1 1 2 1 1 1 1 2| Infarct | | __________________________________________________________________________| Thymus | + + + + + M + + M M + + + + + + + + + M + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + + M + M M M + + M M M + M + + + M + M + M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Necrosis | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Brain Stem, Vacuolization Cytoplasmic| 1 | White Matter, Cerebrum, | | Vacuolization Cytoplasmic | 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Bronchiectasis | 3 | Infiltration Cellular, Histiocyte | 1 1 1 1 1 2 | Inflammation, Acute | 2 | Inflammation, Chronic Active | 1 1 2 1 1 1 2 2 | Inflammation, Granulomatous | | Mineralization | 1 | Alveolar Epithelium, Hyperplasia | 2 1 | Bronchiole, Inflammation, Acute | 2 1 1 | Bronchus, Metaplasia, Squamous | 2 | __________________________________________________________________________| Nose | + + M + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 2 2 | Metaplasia, Squamous | 2 | Nasolacrimal Duct, Inflammation | | _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 6| 2| 6| 6| 3| 3| 6| 2| 5| 6| 6| 5| 6| 6| 6| 3| 7| 7| 2| 7| 6| DAY ON TEST | 3| 3| 4| 4| 4| 9| 6| 6| 0| 0| 7| 3| 9| 3| 1| 2| 4| 4| 4| 5| 3| 1| 7| 3| 7| | 4| 4| 2| 9| 3| 9| 6| 4| 3| 3| 2| 6| 1| 8| 6| 7| 4| 2| 9| 6| 4| 5| 5| 4| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | | Inflammation, Chronic Active | | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Fibrosis | | Hydronephrosis | | Necrosis | 1 | Nephropathy | 1 1 1 1 1 1 2 2 1 1 1 1 1 1 2 1 1 1 2 2 1 2| Artery, Necrosis, Fibrinoid | | Pelvis, Inflammation, Acute | 1 | Renal Tubule, Degeneration | 2 | Transitional Epithelium, Hyperplasia | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation, Chronic Active | 1 | Necrosis | 3 | Transitional Epithelium, Hyperplasia | 1 1 | _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 3| 7| 2| 7| 4| 2| 7| 7| 3| 7| 7| 6| 6| 6| | DAY ON TEST | 0| 7| 8| 3| 3| 2| 3| 3| 3| 6| 4| 6| 3| 5| 3| 9| 2| 3| 3| 9| 1| 1| 3| 0| 0| | | 0| 0| 7| 3| 4| 3| 9| 4| 4| 5| 2| 3| 4| 0| 4| 9| 9| 4| 4| 3| 4| 6| 6| 3| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + M + + + + + + + + M + + + + +| 42 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 1 | 1 1.0| Parasite | 1 1 1 1| 5 1.0| Colon, Erosion | | 1 2.0| Lymphoid Nodule, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ileum, Fibrosis | | 1 1.0| Ileum, Necrosis | | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X| 24 | Eosinophilic Focus | X X | 4 | Fatty Change, Diffuse | 3 4 3 3 3 2 2 3 2 3 3 2 | 27 2.6| Fatty Change, Focal | 2 1 2 1 2 1 2 2 2 2 2 2 2| 23 1.6| Inflammation, Chronic Active | 1 2 2 1 1 1 2 1 | 23 1.3| Mixed Cell Focus | X X X X X | 8 | Necrosis | 1 1 2 1 1 1 1 1 1 1 1 1 | 20 1.1| Bile Duct, Hyperplasia | 1 1 1 1 2 1 1 1 1 1 1 1 1| 22 1.2| __________________________________________________________________________|____________| Mesentery | + | 3 | Fat, Necrosis | | 1 1.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 1 1| 3 1.0| Acinus, Hyperplasia | 1 1 | 3 1.0| Artery, Thrombosis | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + M + + + M + + + + +| 48 | Atrophy | 1 | 1 1.0| Fibrosis | | 1 1.0| Inflammation, Chronic Active | 1 | 3 1.0| Duct, Inflammation, Chronic Active | 1 2 1 2 2 1 1 1 1 1| 22 1.4| Duct, Metaplasia, Squamous | 1 2 1 2 1 2 1 2 2 1 1 1 1 2 1| 31 1.5| __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Forestomach, Hyperkeratosis | 1 1 | 4 1.3| Forestomach, Hyperplasia, Basal Cell | | 3 1.7| Forestomach, Inflammation, Chronic | | | Active | 2 1 1 1 | 10 1.4| Forestomach, Ulcer | 1 1 2 | 10 1.7| Glandular, Necrosis | | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 43 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 3| 7| 2| 7| 4| 2| 7| 7| 3| 7| 7| 6| 6| 6| | DAY ON TEST | 0| 7| 8| 3| 3| 2| 3| 3| 3| 6| 4| 6| 3| 5| 3| 9| 2| 3| 3| 9| 1| 1| 3| 0| 0| | | 0| 0| 7| 3| 4| 3| 9| 4| 4| 5| 2| 3| 4| 0| 4| 9| 9| 4| 4| 3| 4| 6| 6| 3| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 2| 23 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cortex, Hypertrophy, Focal | | 1 1.0| Cortex, Necrosis | 1 | 1 1.0| Medulla, Hyperplasia | 1 1 1 | 6 1.2| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 | 2 1.0| __________________________________________________________________________|____________| Parathyroid Gland | M M + M M M M M M + + + + + + + M M M M + M + + M| 18 | __________________________________________________________________________|____________| Pituitary Gland | + + M + + + + + + + M + + + + + + + + M + + + M +| 45 | Pars Distalis, Angiectasis | | 1 1.0| Pars Distalis, Hyperplasia | 2 1 2 1 1 1 1 | 15 1.3| Pars Nervosa, Cyst | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + M M + + + + + + + + + + M + + + + +| 47 | Mineralization | | 1 1.0| Necrosis | | 1 1.0| Follicle, Cyst | X | 1 | Follicular Cell, Hyperplasia | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + M + + + + + + + +| 41 | Inflammation, Chronic Active | | 1 1.0| __________________________________________________________________________|____________| Preputial Gland | M + + + + + + + + M + M + M + + + + M + +| 34 | Inflammation, Chronic Active | 2 2 1 1 1| 10 1.3| Necrosis | 2 | 7 1.6| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 | 5 1.2| Inflammation, Chronic Active | 4 3 2 1 2 | 19 1.8| Metaplasia, Squamous | 1 2 1 | 12 1.4| Mineralization | 1 | 1 1.0| Epithelium, Hyperplasia | 1 | 3 1.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | | 1 1.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 44 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 3| 7| 2| 7| 4| 2| 7| 7| 3| 7| 7| 6| 6| 6| | DAY ON TEST | 0| 7| 8| 3| 3| 2| 3| 3| 3| 6| 4| 6| 3| 5| 3| 9| 2| 3| 3| 9| 1| 1| 3| 0| 0| | | 0| 0| 7| 3| 4| 3| 9| 4| 4| 5| 2| 3| 4| 0| 4| 9| 9| 4| 4| 3| 4| 6| 6| 3| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Spermatocele | X | 1 | Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| 39 1.1| Seminiferous Tubule, Atrophy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 3 1 2| 33 1.2| Seminiferous Tubule, Giant Cell | | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Lymph Node | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | Lumbar, Pigmentation | 3 | 1 3.0| Mediastinal, Angiectasis | 1 1| 3 1.0| Mediastinal, Congestion | | 1 1.0| Mediastinal, Depletion Lymphoid | | 1 1.0| Mediastinal, Hemorrhage | 1 | 1 1.0| Mediastinal, Pigmentation | 1 2 1 1 1 1| 12 1.3| Mesenteric, Infiltration Cellular, | | | Mast Cell | | 2 1.0| Pancreatic, Pigmentation | | 1 1.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Depletion Lymphoid | 1 | 4 1.0| Hematopoietic Cell Proliferation | 1 1 1 1 1 1 2 1 1 1 2 2 1 1 1 1 1 | 35 1.2| Infarct | 2 | 1 2.0| __________________________________________________________________________|____________| Thymus | M M M + + + + + + + + + + + + + + + + M + M + + +| 41 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M + + + M M M M M M + M M M + M M M M M M M + M| 19 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 1 | 1 1.0| Necrosis | 2 2 | 2 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Brain Stem, Vacuolization Cytoplasmic| 1 | 2 1.0| White Matter, Cerebrum, | | | Vacuolization Cytoplasmic | 1 | 2 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 45 NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BROMOFORM Date: 05/06/97 Route: GAVAGE Time: 08:35:28 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 3| 7| 2| 7| 4| 2| 7| 7| 3| 7| 7| 6| 6| 6| | DAY ON TEST | 0| 7| 8| 3| 3| 2| 3| 3| 3| 6| 4| 6| 3| 5| 3| 9| 2| 3| 3| 9| 1| 1| 3| 0| 0| | | 0| 0| 7| 3| 4| 3| 9| 4| 4| 5| 2| 3| 4| 0| 4| 9| 9| 4| 4| 3| 4| 6| 6| 3| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bronchiectasis | | 1 3.0| Infiltration Cellular, Histiocyte | 1 1 1 1 1 2 1 | 13 1.2| Inflammation, Acute | 2 | 2 2.0| Inflammation, Chronic Active | 1 1 1 1 1 2 1 | 15 1.3| Inflammation, Granulomatous | 2 | 1 2.0| Mineralization | | 1 1.0| Alveolar Epithelium, Hyperplasia | 2 2 | 4 1.8| Bronchiole, Inflammation, Acute | | 3 1.3| Bronchus, Metaplasia, Squamous | | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + M + + + + + + +| 38 | Inflammation, Chronic Active | 1 | 4 1.5| Metaplasia, Squamous | | 1 2.0| Nasolacrimal Duct, Inflammation | 2 | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + | 2 | Inflammation, Chronic Active | 1 | 1 1.0| __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X | 1 | Fibrosis | 1 | 1 1.0| Hydronephrosis | 1 | 1 1.0| Necrosis | 2 | 2 1.5| Nephropathy | 2 1 2 1 1 1 1 2 2 1 1 1 1 1 2 2 1 1 1 2 1 2 1| 45 1.3| Artery, Necrosis, Fibrinoid | 1 | 1 1.0| Pelvis, Inflammation, Acute | | 1 1.0| Renal Tubule, Degeneration | | 1 2.0| Transitional Epithelium, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 4 1 | 2 2.5| Inflammation, Chronic Active | 1 | 2 1.0| Necrosis | 4 1 | 3 2.7| Transitional Epithelium, Hyperplasia | 1 | 3 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 46 ------------------------------------------------------------ ---------- END OF REPORT ---------- 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