TDMS Study 05053-01 Pathology Tables
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
Facility: TSI Mason Research
Chemical CAS #: 75-25-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 4| 4| 4| 5| 4| 7| 4| 4| 6| 4| 3| 3| 4| 0| 4| 4| 4| 2| 4| 4| 5| 4| 4| 4| 2|
| 2| 2| 2| 1| 2| 1| 2| 2| 1| 2| 9| 9| 2| 1| 2| 2| 2| 9| 2| 2| 9| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + A + + + + + + + + + + + + + +|
Parasite | 1 |
Colon, Fibrosis | 1 |
Colon, Necrosis | 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X|
Fatty Change, Diffuse | 2 2 1 3 2|
Fatty Change, Focal | 1 1 2 1 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Multifocal | |
Inflammation, Chronic Active | 1 1 1 1 1 |
Mixed Cell Focus | X |
Necrosis | 1 1 3 1 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + A + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 3 2 1 2 1 |
Acinus, Hyperplasia | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Acanthosis | 1 1 2 2 1|
Forestomach, Hyperkeratosis | 1 1 1 2 2 1|
Forestomach, Inflammation, Chronic | |
Active | 1 1|
Forestomach, Ulcer | 2 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Cortex, Hyperplasia | 2 |
Medulla, Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + M M + M M M + M M M + + + M + + M M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Pars Distalis, Angiectasis | 1 2 3 3 1 2 3 1 2 1 2 2 3 1 1|
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hyperplasia | 1 2 1 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 4| 4| 4| 5| 4| 7| 4| 4| 6| 4| 3| 3| 4| 0| 4| 4| 4| 2| 4| 4| 5| 4| 4| 4| 2|
| 2| 2| 2| 1| 2| 1| 2| 2| 1| 2| 9| 9| 2| 1| 2| 2| 2| 9| 2| 2| 9| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Intermedia, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + M + + M + M M + + + + M M + + + + M + +|
Inflammation, Chronic Active | 1 |
Necrosis | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Inflammation, Chronic Active | 2 |
Mineralization | 1 |
Interstitium, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + M + + + +|
Angiectasis | 2 |
Hemorrhage | 1 |
Inflammation, Chronic Active | 2 |
Mineralization | 1 |
Necrosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Pigmentation | 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 1 2 1 1 2 1 1 2 3 1 1 1 2 2 1 1 |
Hemorrhage | 2 |
Necrosis | |
Pigmentation | 3 1 2 1 1|
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +|
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + M + M + + + + + + M M +|
Galactocele | X X X X X X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 4| 4| 4| 5| 4| 7| 4| 4| 6| 4| 3| 3| 4| 0| 4| 4| 4| 2| 4| 4| 5| 4| 4| 4| 2|
| 2| 2| 2| 1| 2| 1| 2| 2| 1| 2| 9| 9| 2| 1| 2| 2| 2| 9| 2| 2| 9| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Hemorrhage | 2 1 |
Cerebellum, Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 1|
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + M + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 1 1 2 1 2 2 1 1 1 1 2 2 1 1 3|
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + A + + M M + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | 1 |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| |
DAY ON TEST | 8| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 9| 4| 4| 4| 1| 4| 3| 3| |
| 6| 2| 2| 2| 2| 2| 1| 2| 1| 2| 3| 2| 3| 6| 2| 3| 2| 1| 3| 3| 2| 0| 3| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
Parasite | 2 1 1 1 | 5 1.2|
Colon, Fibrosis | | 1 1.0|
Colon, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X | 28 |
Fatty Change, Diffuse | 2 1 4 | 8 2.1|
Fatty Change, Focal | 1 2 2 1 1 1 1 | 11 1.3|
Hepatodiaphragmatic Nodule | X X | 3 |
Hyperplasia, Multifocal | 2 | 1 2.0|
Inflammation, Chronic Active | 3 1 2 1 | 9 1.3|
Mixed Cell Focus | X X X X X X X| 8 |
Necrosis | 1 2 1 2 1 1 1 | 11 1.4|
Bile Duct, Hyperplasia | 1 1 2 1 2 2 1 2 1 1 1 | 17 1.2|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Fat, Necrosis | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
Acinus, Atrophy | 1 2 1 1 1 1 | 12 1.4|
Acinus, Hyperplasia | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Forestomach, Acanthosis | 2 | 6 1.5|
Forestomach, Hyperkeratosis | 2 | 7 1.4|
Forestomach, Inflammation, Chronic | | |
Active | 1 | 3 1.0|
Forestomach, Ulcer | | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 | 34 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 1| 1 1.0|
Cortex, Hyperplasia | | 1 2.0|
Medulla, Hyperplasia | | 4 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| |
DAY ON TEST | 8| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 9| 4| 4| 4| 1| 4| 3| 3| |
| 6| 2| 2| 2| 2| 2| 1| 2| 1| 2| 3| 2| 3| 6| 2| 3| 2| 1| 3| 3| 2| 0| 3| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M M M M + M M M M M + + + + + + M M M M + M M| 21 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Angiectasis | 1 2 2 2 1 2 2 2 2 2 1 3 | 27 1.9|
Pars Distalis, Cyst | X X | 6 |
Pars Distalis, Hyperplasia | 2 1 1 2 2 1 | 9 1.4|
Pars Intermedia, Hyperplasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 | 9 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + + M M M + + M + + + M + + M M + +| 34 |
Inflammation, Chronic Active | 2 | 2 1.5|
Necrosis | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X| 5 |
Inflammation, Chronic Active | 2 | 2 2.0|
Mineralization | | 1 1.0|
Interstitium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 2.0|
Hemorrhage | | 1 1.0|
Inflammation, Chronic Active | | 1 2.0|
Mineralization | | 1 1.0|
Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Pigmentation | | 2 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Depletion Lymphoid | 1 | 1 1.0|
Hematopoietic Cell Proliferation | 1 1 2 2 2 2 1 1 1 2 2 1 2 1 2 1 2 2 1| 35 1.5|
Hemorrhage | | 1 2.0|
Necrosis | 2 | 1 2.0|
Pigmentation | 2 1 | 7 1.6|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| |
DAY ON TEST | 8| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 9| 4| 4| 4| 1| 4| 3| 3| |
| 6| 2| 2| 2| 2| 2| 1| 2| 1| 2| 3| 2| 3| 6| 2| 3| 2| 1| 3| 3| 2| 0| 3| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Epithelial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + M + + + + + + + M + + + + + + + + + +| 44 |
Galactocele | X X X X X X X X X X X | 25 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Brain Stem, Hemorrhage | | 2 1.5|
Cerebellum, Hemorrhage | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 1 1 1 1 2 1 1| 11 1.1|
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Chronic Active | 1 | 4 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 1 1 1 1 2 1 1 1 2 2 1 1 1 1 1 2 1 2 2 1 | 40 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + +| 45 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 2 1.5|
Necrosis | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
_____________________________________________________________________________________________________________________
| 2| 7| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 6| 7| 7| 6| 7| 7| 6| 5|
DAY ON TEST | 7| 3| 1| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 2| 3| 3| 7| 3| 3| 0| 7|
| 9| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 5| 8| 2| 8| 8| 8| 5| 8| 8| 7| 8| 8| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + A + + A +|
Parasite | |
Colon, Necrosis | |
__________________________________________________________________________|
Intestine Small | + + + + A + A +|
Lymphoid Nodule, Mineralization | 1|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + M + + + + + + + +|
Basophilic Focus | X X X X X X X|
Cyst | |
Eosinophilic Focus | |
Fatty Change, Diffuse | 1 2 2 2|
Fatty Change, Focal | 1 1 2 1 1 1 1 2 1 1 2 1 1 1 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Focal | |
Hyperplasia, Multifocal | 2 |
Inflammation, Chronic Active | 1 1 1 1 2 1 |
Mixed Cell Focus | X X X X X X X X X X X X X X X |
Necrosis | 1 1 1 |
Bile Duct, Hyperplasia | 1 2 2 |
__________________________________________________________________________|
Mesentery | + |
Artery, Necrosis, Fibrinoid | |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + M + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 |
Acinus, Hyperplasia | 1 |
Artery, Inflammation, Chronic Active | |
Artery, Necrosis, Fibrinoid | |
Artery, Pigmentation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + M + + + + + + + +|
Duct, Ectasia | 1 |
Duct, Inflammation, Chronic Active | 1|
Duct, Metaplasia, Squamous | 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + +|
Forestomach, Acanthosis | 2 2 1 1 |
Forestomach, Hyperkeratosis | 2 2 1 2 1 1 |
Forestomach, Inflammation, Chronic | |
Active | 2 1 |
Forestomach, Ulcer | 2 1 |
Glandular, Abscess | |
Glandular, Inflammation, Chronic | |
Active | |
Glandular, Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
_____________________________________________________________________________________________________________________
| 2| 7| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 6| 7| 7| 6| 7| 7| 6| 5|
DAY ON TEST | 7| 3| 1| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 2| 3| 3| 7| 3| 3| 0| 7|
| 9| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 5| 8| 2| 8| 8| 8| 5| 8| 8| 7| 8| 8| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + M + + +|
Cardiomyopathy | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + +|
Necrosis | 3 1|
Medulla, Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + M + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
__________________________________________________________________________|
Parathyroid Gland | M M + M + + + M M + + M|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M M + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 1 2 2 1 2 2 |
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hyperplasia | 1 1 1 1 1 2 |
__________________________________________________________________________|
Thyroid Gland | M + + + + + + + + + + + + + + + M + + + + + + + +|
Necrosis | 3 |
C-Cell, Hyperplasia | |
Follicular Cell, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M M M + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | + + + + + + + + +|
Cyst | X |
Necrosis | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Decidual Reaction | X |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + M + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Pigmentation | |
Mandibular, Infiltration Cellular, | |
Plasma Cell | |
Mediastinal, Pigmentation | |
Mesenteric, Depletion Lymphoid | |
Pancreatic, Infiltration Cellular, | |
Plasma Cell | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
_____________________________________________________________________________________________________________________
| 2| 7| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 6| 7| 7| 6| 7| 7| 6| 5|
DAY ON TEST | 7| 3| 1| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 2| 3| 3| 7| 3| 3| 0| 7|
| 9| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 5| 8| 2| 8| 8| 8| 5| 8| 8| 7| 8| 8| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 1 1 2 2 2 2 1 1 |
Necrosis | |
Pigmentation | 1 3 2 |
__________________________________________________________________________|
Thymus | M + + M + M +|
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + M + + + + + M + + + M + + + + + + M +|
Galactocele | |
Necrosis | |
__________________________________________________________________________|
Skin | + + + + + + + M + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + M + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + M + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 |
Inflammation, Chronic Active | 1 1 |
Inflammation, Granulomatous | 1 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Lens, Synechia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Nephropathy | 4 1 1 1 2 1 1 1 2 1 1 1 1 2 1 2 1 2 1 1|
Transitional Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Urinary Bladder | + M + A + + +|
Mineralization | 1 |
Transitional Epithelium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 0| 6| 7| 5| 7| 6| 7| 7| 6| 7| 6| 6| 7| 0| 7| 7| 5| 5| 3| |
DAY ON TEST | 3| 3| 4| 3| 1| 4| 5| 5| 4| 8| 4| 0| 4| 4| 2| 4| 8| 3| 4| 4| 4| 4| 7| 2| 4| |
| 8| 8| 0| 8| 8| 0| 2| 3| 0| 5| 0| 7| 0| 0| 8| 0| 7| 8| 0| 9| 0| 0| 7| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + M + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + +| 18 |
Parasite | 1 | 1 1.0|
Colon, Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + +| 16 |
Lymphoid Nodule, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X X X X X X X X | 15 |
Cyst | X X | 2 |
Eosinophilic Focus | X X | 2 |
Fatty Change, Diffuse | 2 2 1 2 2 2 2 2 2 | 13 1.8|
Fatty Change, Focal | 1 1 1 1 1 1 2 1 1 1 2 1 | 26 1.2|
Hepatodiaphragmatic Nodule | X | 2 |
Hyperplasia, Focal | 2 | 1 2.0|
Hyperplasia, Multifocal | 2 | 2 2.0|
Inflammation, Chronic Active | 1 1 | 8 1.1|
Mixed Cell Focus | X X X X X X X X X X | 25 |
Necrosis | | 3 1.0|
Bile Duct, Hyperplasia | 2 2 1 2 1 1 2 | 10 1.6|
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Artery, Necrosis, Fibrinoid | 2 | 1 2.0|
Fat, Inflammation, Chronic Active | 2 | 1 2.0|
Fat, Necrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | 1 1 1 1 2 | 7 1.1|
Acinus, Hyperplasia | 2 | 2 1.5|
Artery, Inflammation, Chronic Active | 1 | 1 1.0|
Artery, Necrosis, Fibrinoid | 2 1 | 2 1.5|
Artery, Pigmentation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Duct, Ectasia | | 1 1.0|
Duct, Inflammation, Chronic Active | 1 1 2 2 1 2 1 1 | 9 1.3|
Duct, Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + +| 26 |
Forestomach, Acanthosis | 2 1 1 | 7 1.4|
Forestomach, Hyperkeratosis | 1 1| 8 1.4|
Forestomach, Inflammation, Chronic | | |
Active | 2 | 3 1.7|
Forestomach, Ulcer | 2 2 | 4 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 0| 6| 7| 5| 7| 6| 7| 7| 6| 7| 6| 6| 7| 0| 7| 7| 5| 5| 3| |
DAY ON TEST | 3| 3| 4| 3| 1| 4| 5| 5| 4| 8| 4| 0| 4| 4| 2| 4| 8| 3| 4| 4| 4| 4| 7| 2| 4| |
| 8| 8| 0| 8| 8| 0| 2| 3| 0| 5| 0| 7| 0| 0| 8| 0| 7| 8| 0| 9| 0| 0| 7| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Glandular, Abscess | 2 | 1 2.0|
Glandular, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
Glandular, Necrosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + +| 16 |
Cardiomyopathy | 1 1 2 1 1 1 1 | 12 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + M + +| 18 |
Necrosis | | 2 2.0|
Medulla, Hyperplasia | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectopic Tissue | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + M M M +| 16 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + M +| 46 |
Pars Distalis, Angiectasis | 1 1 1 2 | 11 1.5|
Pars Distalis, Cyst | X X X X | 8 |
Pars Distalis, Hyperplasia | 1 1 1 2 1 1 1 2 2 | 15 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 47 |
Necrosis | | 1 3.0|
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 | 7 1.0|
Follicular Cell, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + + + + + + | 9 |
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + +| 20 |
Cyst | X| 2 |
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Decidual Reaction | | 1 |
__________________________________________________________________________|____________|
Vagina | + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 0| 6| 7| 5| 7| 6| 7| 7| 6| 7| 6| 6| 7| 0| 7| 7| 5| 5| 3| |
DAY ON TEST | 3| 3| 4| 3| 1| 4| 5| 5| 4| 8| 4| 0| 4| 4| 2| 4| 8| 3| 4| 4| 4| 4| 7| 2| 4| |
| 8| 8| 0| 8| 8| 0| 2| 3| 0| 5| 0| 7| 0| 0| 8| 0| 7| 8| 0| 9| 0| 0| 7| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Lumbar, Pigmentation | 2 | 1 2.0|
Mandibular, Infiltration Cellular, | | |
Plasma Cell | 2 | 1 2.0|
Mediastinal, Pigmentation | 2 1 | 2 1.5|
Mesenteric, Depletion Lymphoid | 1 | 1 1.0|
Pancreatic, Infiltration Cellular, | | |
Plasma Cell | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + +| 28 |
Depletion Lymphoid | 2 1 | 2 1.5|
Hematopoietic Cell Proliferation | 1 1 1 2 2 2 2 1 1 | 17 1.5|
Necrosis | 2 | 1 2.0|
Pigmentation | 1 2 2| 6 1.8|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + +| 14 |
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + M + + + + + + + + + + + + M + + + + +| 42 |
Galactocele | X X X X | 4 |
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Hyperkeratosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + +| 16 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + +| 17 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + +| 32 |
Infiltration Cellular, Histiocyte | 1 1 1 1| 8 1.0|
Inflammation, Chronic Active | 1 1 | 4 1.0|
Inflammation, Granulomatous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + | 12 |
Hemorrhage | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 0| 6| 7| 5| 7| 6| 7| 7| 6| 7| 6| 6| 7| 0| 7| 7| 5| 5| 3| |
DAY ON TEST | 3| 3| 4| 3| 1| 4| 5| 5| 4| 8| 4| 0| 4| 4| 2| 4| 8| 3| 4| 4| 4| 4| 7| 2| 4| |
| 8| 8| 0| 8| 8| 0| 2| 3| 0| 5| 0| 7| 0| 0| 8| 0| 7| 8| 0| 9| 0| 0| 7| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 3 |
Lens, Cataract | X X | 2 |
Lens, Synechia | 1 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Nephropathy | 2 2 2 3 2 2 2 2 1 2 1 1 2 1 1 2 2 3 2 3 2| 41 1.7|
Transitional Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + M + + + + + +| 14 |
Mineralization | 1 | 2 1.0|
Transitional Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 5| 4| 7| 6| 6| 6| 7| 7| 7| 7| 7| 5| 6| 6| 7|
DAY ON TEST | 3| 3| 1| 3| 3| 1| 3| 3| 7| 3| 4| 8| 3| 6| 6| 3| 3| 3| 2| 3| 2| 5| 1| 0| 3|
| 6| 6| 4| 6| 6| 3| 7| 7| 3| 7| 3| 3| 7| 4| 5| 7| 8| 7| 5| 8| 1| 5| 8| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + A + + + + + + + + + + + + + +|
Parasite | 1 1 |
Cecum, Inflammation, Acute | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X |
Clear Cell Focus | X |
Eosinophilic Focus | X |
Fatty Change, Diffuse | 2 2 2 2 2 2 2 2 2 2 2 2 3 |
Fatty Change, Focal | 1 2 2 2 1 2 1 1 1 1 1|
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Diffuse | |
Hyperplasia, Focal | |
Hyperplasia, Multifocal | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | X X X X X X X X X X X X X|
Necrosis | 2 |
Bile Duct, Hyperplasia | 1 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 2 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 |
Acinus, Hyperplasia | |
Duct, Ectasia | 1 2 2 |
Duct, Inflammation, Chronic Active | 2 1 2 2 2 1 1 1 1 1 |
Duct, Metaplasia, Squamous | 2 1 1 2 2 1 2 2 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Acanthosis | 1 1 1 |
Forestomach, Hyperkeratosis | 2 |
Forestomach, Inflammation, Chronic | |
Active | 1 |
Forestomach, Ulcer | 2 |
Glandular, Hyperplasia, Lymphoid | 2 |
Glandular, Inflammation, Chronic | |
Active | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 2 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 5| 4| 7| 6| 6| 6| 7| 7| 7| 7| 7| 5| 6| 6| 7|
DAY ON TEST | 3| 3| 1| 3| 3| 1| 3| 3| 7| 3| 4| 8| 3| 6| 6| 3| 3| 3| 2| 3| 2| 5| 1| 0| 3|
| 6| 6| 4| 6| 6| 3| 7| 7| 3| 7| 3| 3| 7| 4| 5| 7| 8| 7| 5| 8| 1| 5| 8| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Hyperplasia | 1 |
Medulla, Hyperplasia | 1 1 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + M M M M M + M M + M + M M + M + M + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + M + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 1 2 1 1 |
Pars Intermedia, Cyst | X |
Pars Intermedia, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + + M + + + + + + + M + + +|
Inflammation, Chronic Active | |
Necrosis | 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | 1 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Hematopoietic Cell | |
Proliferation | |
Mandibular, Infiltration Cellular, | |
Plasma Cell | |
Mandibular, Pigmentation | |
Mediastinal, Congestion | |
Mediastinal, Infiltration Cellular, | |
Mast Cell | |
Mediastinal, Pigmentation | 1 |
Mesenteric, Depletion Lymphoid | |
Mesenteric, Infiltration Cellular, | |
Mast Cell | |
Mesenteric, Pigmentation | 1 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 5| 4| 7| 6| 6| 6| 7| 7| 7| 7| 7| 5| 6| 6| 7|
DAY ON TEST | 3| 3| 1| 3| 3| 1| 3| 3| 7| 3| 4| 8| 3| 6| 6| 3| 3| 3| 2| 3| 2| 5| 1| 0| 3|
| 6| 6| 4| 6| 6| 3| 7| 7| 3| 7| 3| 3| 7| 4| 5| 7| 8| 7| 5| 8| 1| 5| 8| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Infiltration Cellular, | |
Mast Cell | 1 |
Pancreatic, Pigmentation | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 1 2 2 2 1 1 2 2 1 1 1 2 1 1 1 1 1 1 1|
Pigmentation | 2 1 1 2 1 2 1 2 1 2 2 1 1 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +|
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + M + + + M + + + + + + + + + + + +|
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Hemorrhage | 1 |
Cerebellum, Inflammation, Chronic | |
Active | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | |
Inflammation, Granulomatous | |
Bronchus, Metaplasia, Squamous | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Metaplasia, Squamous | 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic Active | 2 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Inflammation, Acute | |
Synechia | 2 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 5| 4| 7| 6| 6| 6| 7| 7| 7| 7| 7| 5| 6| 6| 7|
DAY ON TEST | 3| 3| 1| 3| 3| 1| 3| 3| 7| 3| 4| 8| 3| 6| 6| 3| 3| 3| 2| 3| 2| 5| 1| 0| 3|
| 6| 6| 4| 6| 6| 3| 7| 7| 3| 7| 3| 3| 7| 4| 5| 7| 8| 7| 5| 8| 1| 5| 8| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Lens, Cataract | X |
Lens, Inflammation, Acute | |
__________________________________________________________________________|
Harderian Gland | + + |
Abscess | 2 |
Duct, Metaplasia, Squamous | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Necrosis | 3 |
Nephropathy | 2 2 2 2 1 1 1 2 2 2 2 2 2 2 2 1 2 2 1 1 1|
Transitional Epithelium, Hyperplasia | 1 |
Transitional Epithelium, Metaplasia, | |
Osseous | 1 |
Transitional Epithelium, | |
Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + M M + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 7| 7| 7| 7| 6| 5| 7| |
DAY ON TEST | 3| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 6| 3| 3| 1| 3| 2| 4| 8| 3| |
| 7| 2| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 3| 8| 8| 3| 8| 2| 0| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite | 1 1 1 1 1 | 7 1.0|
Cecum, Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X | 13 |
Clear Cell Focus | | 1 |
Eosinophilic Focus | X | 2 |
Fatty Change, Diffuse | 3 2 2 3 2 2 2 | 20 2.2|
Fatty Change, Focal | 1 1 2 1 1 1 1 1 2 1 1 1 2 1 1| 26 1.3|
Hepatodiaphragmatic Nodule | X | 2 |
Hyperplasia, Diffuse | 3 | 1 3.0|
Hyperplasia, Focal | 2 | 1 2.0|
Hyperplasia, Multifocal | 2 | 1 2.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 27 1.0|
Mixed Cell Focus | X X X X X X X X X X X X X X X| 28 |
Necrosis | 1 | 2 1.5|
Bile Duct, Hyperplasia | 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis | 2 | 3 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | | 3 1.3|
Acinus, Hyperplasia | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 | 3 1.0|
Acinus, Hyperplasia | 1 | 1 1.0|
Duct, Ectasia | 2 1 1 2 1 | 8 1.5|
Duct, Inflammation, Chronic Active | 2 1 2 1 2 | 15 1.5|
Duct, Metaplasia, Squamous | 2 1 2 1 1 2 | 16 1.5|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Forestomach, Acanthosis | 2 | 4 1.3|
Forestomach, Hyperkeratosis | 2 1 1 | 4 1.5|
Forestomach, Inflammation, Chronic | | |
Active | 1 | 2 1.0|
Forestomach, Ulcer | | 1 2.0|
Glandular, Hyperplasia, Lymphoid | | 1 2.0|
Glandular, Inflammation, Chronic | | |
Active | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 7| 7| 7| 7| 6| 5| 7| |
DAY ON TEST | 3| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 6| 3| 3| 1| 3| 2| 4| 8| 3| |
| 7| 2| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 3| 8| 8| 3| 8| 2| 0| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 2 1 2 1 1 1 1 1 1 1 | 22 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cortex, Hyperplasia | 1 2 | 3 1.3|
Medulla, Hyperplasia | 1 1 2 | 7 1.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M + + + + + + M M M M + + M M M M M M M M M +| 20 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Angiectasis | 2 2 3 2 3 2 | 9 2.2|
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia | 1 1 1 | 7 1.1|
Pars Intermedia, Cyst | | 1 |
Pars Intermedia, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + + + M M M + + + M + + + + + + + + + + +| 39 |
Inflammation, Chronic Active | 1 1 | 2 1.0|
Necrosis | 3 | 3 2.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic Active | | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Mandibular, Hematopoietic Cell | | |
Proliferation | 1 | 1 1.0|
Mandibular, Infiltration Cellular, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 7| 7| 7| 7| 6| 5| 7| |
DAY ON TEST | 3| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 6| 3| 3| 1| 3| 2| 4| 8| 3| |
| 7| 2| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 3| 8| 8| 3| 8| 2| 0| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Plasma Cell | 2 2 1 | 3 1.7|
Mandibular, Pigmentation | 1 | 1 1.0|
Mediastinal, Congestion | 2 | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Mast Cell | 1 | 1 1.0|
Mediastinal, Pigmentation | 2 2 2 1 2 | 6 1.7|
Mesenteric, Depletion Lymphoid | 2 1 | 2 1.5|
Mesenteric, Infiltration Cellular, | | |
Mast Cell | 1 | 1 1.0|
Mesenteric, Pigmentation | | 1 1.0|
Pancreatic, Infiltration Cellular, | | |
Mast Cell | | 1 1.0|
Pancreatic, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Lymphoid | 1 1 | 2 1.0|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 2 1 1 2 2 2 2 1 1 1 2 2 1 | 39 1.3|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 | 29 1.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + M M M + + + M M + M M + + + + + + + + +| 39 |
Galactocele | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cerebellum, Hemorrhage | | 1 1.0|
Cerebellum, Inflammation, Chronic | | |
Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 1 2 1 1 1 1 1 | 16 1.1|
Inflammation, Chronic Active | 2 1 1 3 | 4 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 7| 7| 7| 7| 6| 5| 7| |
DAY ON TEST | 3| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 6| 3| 3| 1| 3| 2| 4| 8| 3| |
| 7| 2| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 3| 8| 8| 3| 8| 2| 0| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Granulomatous | 1 | 1 1.0|
Bronchus, Metaplasia, Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Inflammation, Chronic Active | 1 | 2 2.0|
Metaplasia, Squamous | | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 3 2 | 2 2.5|
Inflammation, Chronic Active | 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 4 |
Inflammation, Acute | 3 | 1 3.0|
Synechia | | 1 2.0|
Lens, Cataract | X | 2 |
Lens, Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
Abscess | 4 3 | 3 3.0|
Duct, Metaplasia, Squamous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Necrosis | 2 | 2 2.5|
Nephropathy | 2 1 1 3 2 1 2 2 1 2 2 3 1 2 2 3 3 2 1 2 2 2 2 1 2| 46 1.8|
Transitional Epithelium, Hyperplasia | | 1 1.0|
Transitional Epithelium, Metaplasia, | | |
Osseous | | 1 1.0|
Transitional Epithelium, | | |
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + M + + + + + + + + + + + M +| 46 |
Hemorrhage | | 1 1.0|
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6|
DAY ON TEST | 4| 8| 1| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 1|
| 2| 3| 1| 1| 2| 0| 5| 2| 0| 0| 1| 1| 0| 8| 1| 1| 1| 1| 1| 1| 2| 1| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Hemorrhage | 1 |
Parasite | 1 |
Cecum, Inflammation, Chronic Active | |
Colon, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X |
Eosinophilic Focus | |
Fatty Change, Diffuse | 1 3 2|
Fatty Change, Focal | 1 1 1 1 1 1 1 1 1 2 |
Hyperplasia, Focal | |
Hyperplasia, Multifocal | 2 |
Mixed Cell Focus | X X X |
Necrosis | 2 1 1 2 |
Bile Duct, Hyperplasia | 2 1 2 2 2 1 1 1 1 1 3 2 1 1 2 2 1 1 2 1 2|
__________________________________________________________________________|
Mesentery | + |
Artery, Necrosis, Fibrinoid | 3 |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 |
Acinus, Hyperplasia | 1 1 |
Artery, Necrosis, Fibrinoid | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Acanthosis | |
Forestomach, Hyperkeratosis | 1 1 |
Forestomach, Inflammation, Chronic | |
Active | 1 1 1 |
Forestomach, Necrosis | 1 |
Forestomach, Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 1 2 2 1 1 1 1 2 2 2 2 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
Cortex, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6|
DAY ON TEST | 4| 8| 1| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 1|
| 2| 3| 1| 1| 2| 0| 5| 2| 0| 0| 1| 1| 0| 8| 1| 1| 1| 1| 1| 1| 2| 1| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cortex, Necrosis | 2 |
Medulla, Hyperplasia | 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M M + M + + M + + + + M M M + + + M M M M M M M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 1 2 2 2|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 1 1 1 1 |
Pars Intermedia, Hyperplasia | 1 |
Pars Nervosa, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 |
Capsule, Necrosis, Fibrinoid | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + M + + + + + + + + M + + + + + + + +|
Fibrosis | 1 |
Inflammation, Chronic Active | 2 2 1 1 |
Mineralization | |
Necrosis | 2 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + M + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Inflammation, Acute | |
Inflammation, Chronic Active | 1 2 1 1 1 1 2 1 2 |
Metaplasia, Squamous | 1 1 |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Seminiferous Tubule, Atrophy | 2 1 2 1 1 1 2 1 1 2 1 1 1 2 2 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Pigmentation | 2 |
Mediastinal, Angiectasis | |
Mediastinal, Hemorrhage | 1 |
Mediastinal, Pigmentation | 1 |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6|
DAY ON TEST | 4| 8| 1| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 1|
| 2| 3| 1| 1| 2| 0| 5| 2| 0| 0| 1| 1| 0| 8| 1| 1| 1| 1| 1| 1| 2| 1| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesenteric, Angiectasis | |
Pancreatic, Angiectasis | 3|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 1 1 2 1 1 1 1 3 1 2 1 3 1 1 |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelial Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M M + M M M + M M M + M + + M M M M + M + M +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Cyst Epithelial Inclusion | |
Hyperkeratosis | 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchiectasis | |
Edema | |
Infiltration Cellular, Histiocyte | 1 1 2 |
Inflammation, Acute | |
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hydronephrosis | 1 |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6|
DAY ON TEST | 4| 8| 1| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 1|
| 2| 3| 1| 1| 2| 0| 5| 2| 0| 0| 1| 1| 0| 8| 1| 1| 1| 1| 1| 1| 2| 1| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 2 2 2 2 2 1 2 2 3 3 2 2 3 2 2 2 3 2 3 1 3 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hemorrhage | 1 |
Inflammation, Chronic Active | |
Necrosis | 1 |
Transitional Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 3| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 2| 3| 4| 4| 4| 4| 7| 2| 4| 8| 4| 5| 7| 4| 4| 2| 4| 8| 1| 4| 4| 4| 4| 4| |
| 2| 4| 2| 2| 2| 2| 2| 9| 1| 2| 6| 2| 8| 7| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + M| 47 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | | 1 2.0|
Hemorrhage | | 1 1.0|
Parasite | 1 | 2 1.0|
Cecum, Inflammation, Chronic Active | 3 | 1 3.0|
Colon, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X| 28 |
Eosinophilic Focus | X | 1 |
Fatty Change, Diffuse | 2 2 | 5 2.0|
Fatty Change, Focal | 1 1 1 2 1 1 1 2| 18 1.2|
Hyperplasia, Focal | 2 2 | 2 2.0|
Hyperplasia, Multifocal | 2| 2 2.0|
Mixed Cell Focus | X X X X X X X | 10 |
Necrosis | 2 1 1 | 7 1.4|
Bile Duct, Hyperplasia | 1 2 2 2 2 1 1 1 1 2 1 1 1 1 1 2 2 1| 39 1.5|
__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
Artery, Necrosis, Fibrinoid | | 1 3.0|
Fat, Inflammation, Chronic Active | 2 | 1 2.0|
Fat, Necrosis | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 2 2 1 | 6 1.5|
Acinus, Hyperplasia | 1 1 | 4 1.0|
Artery, Necrosis, Fibrinoid | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Forestomach, Acanthosis | 3| 1 3.0|
Forestomach, Hyperkeratosis | 1 1 2 3| 6 1.5|
Forestomach, Inflammation, Chronic | | |
Active | 1| 4 1.0|
Forestomach, Necrosis | 1 1| 3 1.0|
Forestomach, Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 2 1 1 2 2 2 2 2 1 1 2 2 1 1 2 1 2 1 1 1| 42 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 3| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 2| 3| 4| 4| 4| 4| 7| 2| 4| 8| 4| 5| 7| 4| 4| 2| 4| 8| 1| 4| 4| 4| 4| 4| |
| 2| 4| 2| 2| 2| 2| 2| 9| 1| 2| 6| 2| 8| 7| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + M + + + + + + + + M| 48 |
Thrombosis | 1 | 1 1.0|
Cortex, Hyperplasia | 1 1 | 3 1.0|
Cortex, Necrosis | | 1 2.0|
Medulla, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 | 21 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
Hyperplasia | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M M M + + + + + M + M M M M M + + M M + M M M + M| 20 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 1 2 3 3 2 | 11 1.9|
Pars Distalis, Cyst | X | 2 |
Pars Distalis, Hyperplasia | 1 2 1 1 | 9 1.1|
Pars Intermedia, Hyperplasia | 2 | 2 1.5|
Pars Nervosa, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
C-Cell, Hyperplasia | 1 | 3 1.0|
Capsule, Necrosis, Fibrinoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + M + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + M M + + M + + + + +| 41 |
Fibrosis | 2 | 2 1.5|
Inflammation, Chronic Active | 1 2 2 | 7 1.6|
Mineralization | 1 | 1 1.0|
Necrosis | 2 2 2 | 7 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis | 1 | 2 1.5|
Inflammation, Acute | 4 | 1 4.0|
Inflammation, Chronic Active | 2 2 2 1 2 3 1 | 16 1.6|
Metaplasia, Squamous | | 2 1.0|
Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 3| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 2| 3| 4| 4| 4| 4| 7| 2| 4| 8| 4| 5| 7| 4| 4| 2| 4| 8| 1| 4| 4| 4| 4| 4| |
| 2| 4| 2| 2| 2| 2| 2| 9| 1| 2| 6| 2| 8| 7| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 37 1.0|
Seminiferous Tubule, Atrophy | 1 1 1 1 1 1 2 1 2 3 1 1 2 1 1 1 1 1 2 1| 40 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumbar, Pigmentation | | 1 2.0|
Mediastinal, Angiectasis | 1 2 | 2 1.5|
Mediastinal, Hemorrhage | | 1 1.0|
Mediastinal, Pigmentation | 2 | 2 1.5|
Mesenteric, Angiectasis | 2 | 1 2.0|
Pancreatic, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 1 2 1 2 1 2 2 2 1 2 1 1 1 1| 30 1.4|
Pigmentation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + M + + M M + + + + +| 47 |
Epithelial Cell, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M M M M M + M M + + M M M M + M + + + M + + +| 20 |
Galactocele | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Acanthosis | | 1 2.0|
Cyst Epithelial Inclusion | X | 1 |
Hyperkeratosis | 2 | 2 2.0|
Necrosis | 4 2| 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Joint, Tarsal, Hyperostosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bronchiectasis | 1 | 1 1.0|
Edema | 1 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 3| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 2| 3| 4| 4| 4| 4| 7| 2| 4| 8| 4| 5| 7| 4| 4| 2| 4| 8| 1| 4| 4| 4| 4| 4| |
| 2| 4| 2| 2| 2| 2| 2| 9| 1| 2| 6| 2| 8| 7| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Infiltration Cellular, Histiocyte | 1 1 1 2 1 | 8 1.3|
Inflammation, Acute | 3 | 1 3.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 3 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Hydronephrosis | | 1 1.0|
Nephropathy | 2 2 1 2 3 1 2 2 1 2 1 1 1 1 2 1 3 1 1 2 3 2 3| 46 1.9|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | 2 3 | 3 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Necrosis | | 1 1.0|
Transitional Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 3| 3| 8| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3| 2| 3| 3|
| 2| 9| 4| 4| 4| 0| 0| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 6| 5| 0| 9| 6| 1| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M + + + M M + + + + + + + + M M + + + + + + M +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite | 1 1 1 |
Lymphoid Nodule, Hyperplasia | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X |
Clear Cell Focus | X |
Degeneration, Cystic | 1|
Eosinophilic Focus | X X X X X X X|
Fatty Change, Diffuse | 1 2 2 1 3 2 2 2 2 |
Fatty Change, Focal | 1 2 1 2 1 1 2 1 1 1 1 2 2 1 1 1|
Focal Cellular Change | |
Hepatodiaphragmatic Nodule | |
Hyperplasia, Focal | 2 |
Hyperplasia, Multifocal | 3 2 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | X X X X |
Necrosis | 2 1 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 1 1 |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 2 1|
Acinus, Hyperplasia | 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Fibrosis | 2 |
Inflammation, Chronic Active | 1 1 |
Duct, Ectasia | 2 2 2 1 |
Duct, Inflammation, Chronic Active | 1 1 1 2 1 2 1 1 |
Duct, Metaplasia, Squamous | 1 1 1 2 1 2 2 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Acanthosis | |
Forestomach, Fibrosis | 2 |
Forestomach, Hyperkeratosis | 1 2 1 2 1 |
Forestomach, Inflammation, Chronic | |
Active | 1 1 |
Forestomach, Ulcer | 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 1 1 1 1 1 1 2 1 1 1 2 2 1 1|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 3| 3| 8| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3| 2| 3| 3|
| 2| 9| 4| 4| 4| 0| 0| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 6| 5| 0| 9| 6| 1| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Cortex, Hyperplasia | 1 |
Cortex, Necrosis | 1 |
Medulla, Hyperplasia | 1 2 1 1 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + M M + M M + + M M M + M + M M M + + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 1 1 1 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 1 1 1 2 1 1 2 1 2 1 1 1 1 1 1 2 1 |
__________________________________________________________________________|
Thyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + M + M M + + M M + + + + M +|
Inflammation, Chronic Active | 1 1 2 1 1 1|
Necrosis | |
__________________________________________________________________________|
Prostate | + + + M + + + + M M + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Inflammation, Chronic Active | 3 2 1 1 1 1 1 1 3 1 |
Metaplasia, Squamous | 2 2 1 |
Mineralization | |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Seminiferous Tubule, Atrophy | 1 2 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1|
Seminiferous Tubule, Giant Cell | 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Infiltration Cellular, | |
Plasma Cell | 2 |
Mandibular, Necrosis | 1 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 3| 3| 8| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3| 2| 3| 3|
| 2| 9| 4| 4| 4| 0| 0| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 6| 5| 0| 9| 6| 1| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Congestion | |
Mediastinal, Depletion Lymphoid | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Fibrosis | 1 |
Hematopoietic Cell Proliferation | 1 1 2 1 3 1 1 2 1 2 1 2 1 1 2 1 1 2 1 1|
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M + M M M M + M M M M M M M M M + M + M + M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + I + + + + + + + + + +|
Cyst | |
Hyperkeratosis | 3 |
Inflammation, Chronic Active | 1 |
Subcutaneous Tissue, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Artery, Thrombosis | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1|
Inflammation, Chronic Active | 1 2 1 2 |
Mineralization | 1 |
Alveolar Epithelium, Hyperplasia | 2 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 3| 3| 8| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3| 2| 3| 3|
| 2| 9| 4| 4| 4| 0| 0| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 6| 5| 0| 9| 6| 1| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cyst | |
Fibrosis, Focal | 2 |
Nephropathy | 1 1 2 1 2 1 1 1 1 2 1 1 1 1 2 1 1 2 1 2 2 2 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 3| 7| 5| 6| 6| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 6| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 4| 9| 3| 3| 3| 2| 5| 3| 1| 3| 3| 3| 0| 3| |
| 3| 6| 6| 6| 9| 6| 9| 6| 6| 6| 6| 2| 4| 7| 6| 7| 1| 9| 6| 4| 6| 6| 6| 7| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + + + + + + + + + + + + + M M + + + M M M M +| 36 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite | 1 1 | 5 1.0|
Lymphoid Nodule, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X | 20 |
Clear Cell Focus | X | 2 |
Degeneration, Cystic | | 1 1.0|
Eosinophilic Focus | X X | 9 |
Fatty Change, Diffuse | 2 2 2 1 | 13 1.8|
Fatty Change, Focal | 2 1 2 1 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1| 36 1.3|
Focal Cellular Change | X | 1 |
Hepatodiaphragmatic Nodule | X | 1 |
Hyperplasia, Focal | | 1 2.0|
Hyperplasia, Multifocal | | 2 2.5|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 29 1.0|
Mixed Cell Focus | X X X X X X X | 11 |
Necrosis | 1 | 3 1.3|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2| 37 1.1|
__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
Fat, Inflammation, Chronic Active | 1 | 1 1.0|
Fat, Necrosis | 2 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 1 1 1 1| 9 1.2|
Acinus, Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Fibrosis | | 1 2.0|
Inflammation, Chronic Active | | 2 1.0|
Duct, Ectasia | 1 | 5 1.6|
Duct, Inflammation, Chronic Active | 1 1 2 2 1 1 | 14 1.3|
Duct, Metaplasia, Squamous | 1 1 2 2 1 1 | 15 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Forestomach, Acanthosis | 3 | 1 3.0|
Forestomach, Fibrosis | 1 | 2 1.5|
Forestomach, Hyperkeratosis | 1 2 1 | 8 1.4|
Forestomach, Inflammation, Chronic | | |
Active | 1 4 | 4 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 3| 7| 5| 6| 6| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 6| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 4| 9| 3| 3| 3| 2| 5| 3| 1| 3| 3| 3| 0| 3| |
| 3| 6| 6| 6| 9| 6| 9| 6| 6| 6| 6| 2| 4| 7| 6| 7| 1| 9| 6| 4| 6| 6| 6| 7| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Forestomach, Ulcer | 2 3 1 | 5 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 2 1 2 2 2 1 1 1 1 2 2 2 2 1 2 2 1 1 1| 39 1.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 2 |
Cortex, Hyperplasia | | 1 1.0|
Cortex, Necrosis | | 1 1.0|
Medulla, Hyperplasia | 1 2 1 1 1 1 1 1 1 | 16 1.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 3 1.7|
__________________________________________________________________________|____________|
Parathyroid Gland | M M + M M M + + M + M + M M M + M M M M + M + + M| 20 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + M + + +| 48 |
Pars Distalis, Angiectasis | 1 2 1 3 1 1 1| 12 1.5|
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia | 1 1 1 1 1 1 2 1 1 | 26 1.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Preputial Gland | M M + + + + + M + + M M + + + + + + + + + + + +| 38 |
Inflammation, Chronic Active | 1 2 1 1 1 | 11 1.2|
Necrosis | 3 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + M + + + + + +| 46 |
Fibrosis | 1 1 | 4 1.5|
Inflammation, Chronic Active | 1 2 1 2 2 2 2 | 17 1.6|
Metaplasia, Squamous | 1 2 1 | 6 1.5|
Mineralization | 2 | 1 2.0|
Epithelium, Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Spermatocele | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 3| 7| 5| 6| 6| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 6| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 4| 9| 3| 3| 3| 2| 5| 3| 1| 3| 3| 3| 0| 3| |
| 3| 6| 6| 6| 9| 6| 9| 6| 6| 6| 6| 2| 4| 7| 6| 7| 1| 9| 6| 4| 6| 6| 6| 7| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 39 1.0|
Seminiferous Tubule, Atrophy | 2 1 1 1 1 1 1 1 1 1 1 1 3 1 2 2 1 1| 38 1.2|
Seminiferous Tubule, Giant Cell | 1 1 1 1| 6 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + M + + + + M + + + + + + + + + + + + + + + +| 48 |
Mandibular, Infiltration Cellular, | | |
Plasma Cell | 2 1 1 | 4 1.5|
Mandibular, Necrosis | | 1 1.0|
Mediastinal, Congestion | 1 | 1 1.0|
Mediastinal, Depletion Lymphoid | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Fibrosis | 2 | 2 1.5|
Hematopoietic Cell Proliferation | 2 1 1 1 2 1 2 1 1 2 1 1 1 1 1 1 | 36 1.3|
Pigmentation | 1 | 2 1.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M M + + + + + + + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M + + M M + + M + + + M M + M M M + M M M| 15 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | X| 1 |
Hyperkeratosis | | 1 3.0|
Inflammation, Chronic Active | 2 2| 3 1.7|
Subcutaneous Tissue, Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 2 | 2 1.5|
Artery, Thrombosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 1 | 3 1.3|
Infiltration Cellular, Histiocyte | 1 1 1 1 | 9 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 3| 7| 5| 6| 6| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 6| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 4| 9| 3| 3| 3| 2| 5| 3| 1| 3| 3| 3| 0| 3| |
| 3| 6| 6| 6| 9| 6| 9| 6| 6| 6| 6| 2| 4| 7| 6| 7| 1| 9| 6| 4| 6| 6| 6| 7| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 2 1 2 | 7 1.6|
Mineralization | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 1 1 | 6 1.3|
__________________________________________________________________________|____________|
Nose | + M + + + + + + + + M + + + + + + + + + M + + +| 46 |
Inflammation, Chronic Active | 1 | 3 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Fibrosis, Focal | | 1 2.0|
Nephropathy | 1 1 2 3 1 1 1 2 2 2 2 2 1 1 2 1 1 1 2 2 3 2 3 1 1| 50 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 2| 6| 6| 3| 3| 6| 2| 5| 6| 6| 5| 6| 6| 6| 3| 7| 7| 2| 7| 6|
DAY ON TEST | 3| 3| 4| 4| 4| 9| 6| 6| 0| 0| 7| 3| 9| 3| 1| 2| 4| 4| 4| 5| 3| 1| 7| 3| 7|
| 4| 4| 2| 9| 3| 9| 6| 4| 3| 3| 2| 6| 1| 8| 6| 7| 4| 2| 9| 6| 4| 5| 5| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + + M M + M + + + + + + + + + + M M +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Parasite | 1 |
Colon, Erosion | 2 |
Lymphoid Nodule, Hyperplasia | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ileum, Fibrosis | 1 |
Ileum, Necrosis | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X|
Eosinophilic Focus | X X |
Fatty Change, Diffuse | 2 2 2 2 3 3 3 3 2 2 3 3 2 3 3|
Fatty Change, Focal | 2 1 1 1 2 2 1 1 2 1 |
Inflammation, Chronic Active | 1 2 1 2 2 1 2 1 1 1 1 1 1 1 1|
Mixed Cell Focus | X X X |
Necrosis | 1 1 1 1 1 2 1 1 |
Bile Duct, Hyperplasia | 1 1 2 1 2 1 1 2 2|
__________________________________________________________________________|
Mesentery | + +|
Fat, Necrosis | 1|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 |
Acinus, Hyperplasia | 1 |
Artery, Thrombosis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Fibrosis | 1 |
Inflammation, Chronic Active | 1 1 |
Duct, Inflammation, Chronic Active | 1 1 1 2 2 1 2 2 1 1 2 1|
Duct, Metaplasia, Squamous | 2 2 1 1 1 1 1 2 2 1 2 3 1 1 2 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Hyperkeratosis | 2 1 |
Forestomach, Hyperplasia, Basal Cell | 1 2 2 |
Forestomach, Inflammation, Chronic | |
Active | 1 1 2 2 1 2|
Forestomach, Ulcer | 2 2 2 2 2 1 2|
Glandular, Necrosis | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 2| 6| 6| 3| 3| 6| 2| 5| 6| 6| 5| 6| 6| 6| 3| 7| 7| 2| 7| 6|
DAY ON TEST | 3| 3| 4| 4| 4| 9| 6| 6| 0| 0| 7| 3| 9| 3| 1| 2| 4| 4| 4| 5| 3| 1| 7| 3| 7|
| 4| 4| 2| 9| 3| 9| 6| 4| 3| 3| 2| 6| 1| 8| 6| 7| 4| 2| 9| 6| 4| 5| 5| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cortex, Hypertrophy, Focal | 1 |
Cortex, Necrosis | |
Medulla, Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | M + M M M M M M M M + M + M + M M + M + M M M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Pars Distalis, Angiectasis | 1 |
Pars Distalis, Hyperplasia | 1 2 1 1 1 2 1 2 |
Pars Nervosa, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Necrosis | 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + M + + M M + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + M + + + + + +|
Inflammation, Chronic Active | 1 2 1 1 1 |
Necrosis | 1 2 1 2 1 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 1 1 1 |
Inflammation, Chronic Active | 1 1 2 2 1 4 1 1 3 1 2 1 2 1|
Metaplasia, Squamous | 1 1 2 1 1 2 1 3 1 |
Mineralization | |
Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | |
Interstitial Cell, Hyperplasia | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1|
Seminiferous Tubule, Atrophy | 1 1 1 1 1 1 3 2 1 1 1 1 1 1|
Seminiferous Tubule, Giant Cell | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + M + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Pigmentation | |
Mediastinal, Angiectasis | 1|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 2| 6| 6| 3| 3| 6| 2| 5| 6| 6| 5| 6| 6| 6| 3| 7| 7| 2| 7| 6|
DAY ON TEST | 3| 3| 4| 4| 4| 9| 6| 6| 0| 0| 7| 3| 9| 3| 1| 2| 4| 4| 4| 5| 3| 1| 7| 3| 7|
| 4| 4| 2| 9| 3| 9| 6| 4| 3| 3| 2| 6| 1| 8| 6| 7| 4| 2| 9| 6| 4| 5| 5| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Congestion | 1 |
Mediastinal, Depletion Lymphoid | 1 |
Mediastinal, Hemorrhage | |
Mediastinal, Pigmentation | 2 2 2 1 1 1|
Mesenteric, Infiltration Cellular, | |
Mast Cell | 1 1 |
Pancreatic, Pigmentation | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 1 1 1 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 2 2 1 1 2 1 1 1 1 2|
Infarct | |
__________________________________________________________________________|
Thymus | + + + + + M + + M M + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + M + M M M + + M M M + M + + + M + M + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Vacuolization Cytoplasmic| 1 |
White Matter, Cerebrum, | |
Vacuolization Cytoplasmic | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchiectasis | 3 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 1 1 2 1 1 1 2 2 |
Inflammation, Granulomatous | |
Mineralization | 1 |
Alveolar Epithelium, Hyperplasia | 2 1 |
Bronchiole, Inflammation, Acute | 2 1 1 |
Bronchus, Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Nose | + + M + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 2 |
Metaplasia, Squamous | 2 |
Nasolacrimal Duct, Inflammation | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 2| 6| 6| 3| 3| 6| 2| 5| 6| 6| 5| 6| 6| 6| 3| 7| 7| 2| 7| 6|
DAY ON TEST | 3| 3| 4| 4| 4| 9| 6| 6| 0| 0| 7| 3| 9| 3| 1| 2| 4| 4| 4| 5| 3| 1| 7| 3| 7|
| 4| 4| 2| 9| 3| 9| 6| 4| 3| 3| 2| 6| 1| 8| 6| 7| 4| 2| 9| 6| 4| 5| 5| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.2 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Fibrosis | |
Hydronephrosis | |
Necrosis | 1 |
Nephropathy | 1 1 1 1 1 1 2 2 1 1 1 1 1 1 2 1 1 1 2 2 1 2|
Artery, Necrosis, Fibrinoid | |
Pelvis, Inflammation, Acute | 1 |
Renal Tubule, Degeneration | 2 |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | 1 |
Necrosis | 3 |
Transitional Epithelium, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 3| 7| 2| 7| 4| 2| 7| 7| 3| 7| 7| 6| 6| 6| |
DAY ON TEST | 0| 7| 8| 3| 3| 2| 3| 3| 3| 6| 4| 6| 3| 5| 3| 9| 2| 3| 3| 9| 1| 1| 3| 0| 0| |
| 0| 0| 7| 3| 4| 3| 9| 4| 4| 5| 2| 3| 4| 0| 4| 9| 9| 4| 4| 3| 4| 6| 6| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + M + + + + + + + + M + + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
Parasite | 1 1 1 1| 5 1.0|
Colon, Erosion | | 1 2.0|
Lymphoid Nodule, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ileum, Fibrosis | | 1 1.0|
Ileum, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X| 24 |
Eosinophilic Focus | X X | 4 |
Fatty Change, Diffuse | 3 4 3 3 3 2 2 3 2 3 3 2 | 27 2.6|
Fatty Change, Focal | 2 1 2 1 2 1 2 2 2 2 2 2 2| 23 1.6|
Inflammation, Chronic Active | 1 2 2 1 1 1 2 1 | 23 1.3|
Mixed Cell Focus | X X X X X | 8 |
Necrosis | 1 1 2 1 1 1 1 1 1 1 1 1 | 20 1.1|
Bile Duct, Hyperplasia | 1 1 1 1 2 1 1 1 1 1 1 1 1| 22 1.2|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 1| 3 1.0|
Acinus, Hyperplasia | 1 1 | 3 1.0|
Artery, Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + M + + + M + + + + +| 48 |
Atrophy | 1 | 1 1.0|
Fibrosis | | 1 1.0|
Inflammation, Chronic Active | 1 | 3 1.0|
Duct, Inflammation, Chronic Active | 1 2 1 2 2 1 1 1 1 1| 22 1.4|
Duct, Metaplasia, Squamous | 1 2 1 2 1 2 1 2 2 1 1 1 1 2 1| 31 1.5|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Forestomach, Hyperkeratosis | 1 1 | 4 1.3|
Forestomach, Hyperplasia, Basal Cell | | 3 1.7|
Forestomach, Inflammation, Chronic | | |
Active | 2 1 1 1 | 10 1.4|
Forestomach, Ulcer | 1 1 2 | 10 1.7|
Glandular, Necrosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 3| 7| 2| 7| 4| 2| 7| 7| 3| 7| 7| 6| 6| 6| |
DAY ON TEST | 0| 7| 8| 3| 3| 2| 3| 3| 3| 6| 4| 6| 3| 5| 3| 9| 2| 3| 3| 9| 1| 1| 3| 0| 0| |
| 0| 0| 7| 3| 4| 3| 9| 4| 4| 5| 2| 3| 4| 0| 4| 9| 9| 4| 4| 3| 4| 6| 6| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 2| 23 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cortex, Hypertrophy, Focal | | 1 1.0|
Cortex, Necrosis | 1 | 1 1.0|
Medulla, Hyperplasia | 1 1 1 | 6 1.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M M + M M M M M M + + + + + + + M M M M + M + + M| 18 |
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + + + + + M + + + + + + + + M + + + M +| 45 |
Pars Distalis, Angiectasis | | 1 1.0|
Pars Distalis, Hyperplasia | 2 1 2 1 1 1 1 | 15 1.3|
Pars Nervosa, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + M M + + + + + + + + + + M + + + + +| 47 |
Mineralization | | 1 1.0|
Necrosis | | 1 1.0|
Follicle, Cyst | X | 1 |
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + M + + + + + + + +| 41 |
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | M + + + + + + + + M + M + M + + + + M + +| 34 |
Inflammation, Chronic Active | 2 2 1 1 1| 10 1.3|
Necrosis | 2 | 7 1.6|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 5 1.2|
Inflammation, Chronic Active | 4 3 2 1 2 | 19 1.8|
Metaplasia, Squamous | 1 2 1 | 12 1.4|
Mineralization | 1 | 1 1.0|
Epithelium, Hyperplasia | 1 | 3 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 3| 7| 2| 7| 4| 2| 7| 7| 3| 7| 7| 6| 6| 6| |
DAY ON TEST | 0| 7| 8| 3| 3| 2| 3| 3| 3| 6| 4| 6| 3| 5| 3| 9| 2| 3| 3| 9| 1| 1| 3| 0| 0| |
| 0| 0| 7| 3| 4| 3| 9| 4| 4| 5| 2| 3| 4| 0| 4| 9| 9| 4| 4| 3| 4| 6| 6| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Spermatocele | X | 1 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| 39 1.1|
Seminiferous Tubule, Atrophy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 3 1 2| 33 1.2|
Seminiferous Tubule, Giant Cell | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Lumbar, Pigmentation | 3 | 1 3.0|
Mediastinal, Angiectasis | 1 1| 3 1.0|
Mediastinal, Congestion | | 1 1.0|
Mediastinal, Depletion Lymphoid | | 1 1.0|
Mediastinal, Hemorrhage | 1 | 1 1.0|
Mediastinal, Pigmentation | 1 2 1 1 1 1| 12 1.3|
Mesenteric, Infiltration Cellular, | | |
Mast Cell | | 2 1.0|
Pancreatic, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Lymphoid | 1 | 4 1.0|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 2 1 1 1 2 2 1 1 1 1 1 | 35 1.2|
Infarct | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M M M + + + + + + + + + + + + + + + + M + M + + +| 41 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + + + M M M M M M + M M M + M M M M M M M + M| 19 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
Necrosis | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Brain Stem, Vacuolization Cytoplasmic| 1 | 2 1.0|
White Matter, Cerebrum, | | |
Vacuolization Cytoplasmic | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05053-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BROMOFORM Date: 05/06/97
Route: GAVAGE Time: 08:35:28
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 3| 7| 2| 7| 4| 2| 7| 7| 3| 7| 7| 6| 6| 6| |
DAY ON TEST | 0| 7| 8| 3| 3| 2| 3| 3| 3| 6| 4| 6| 3| 5| 3| 9| 2| 3| 3| 9| 1| 1| 3| 0| 0| |
| 0| 0| 7| 3| 4| 3| 9| 4| 4| 5| 2| 3| 4| 0| 4| 9| 9| 4| 4| 3| 4| 6| 6| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.2 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
46 HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bronchiectasis | | 1 3.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 2 1 | 13 1.2|
Inflammation, Acute | 2 | 2 2.0|
Inflammation, Chronic Active | 1 1 1 1 1 2 1 | 15 1.3|
Inflammation, Granulomatous | 2 | 1 2.0|
Mineralization | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 2 | 4 1.8|
Bronchiole, Inflammation, Acute | | 3 1.3|
Bronchus, Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + M + + + + + + +| 38 |
Inflammation, Chronic Active | 1 | 4 1.5|
Metaplasia, Squamous | | 1 2.0|
Nasolacrimal Duct, Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Fibrosis | 1 | 1 1.0|
Hydronephrosis | 1 | 1 1.0|
Necrosis | 2 | 2 1.5|
Nephropathy | 2 1 2 1 1 1 1 2 2 1 1 1 1 1 2 2 1 1 1 2 1 2 1| 45 1.3|
Artery, Necrosis, Fibrinoid | 1 | 1 1.0|
Pelvis, Inflammation, Acute | | 1 1.0|
Renal Tubule, Degeneration | | 1 2.0|
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 1 | 2 2.5|
Inflammation, Chronic Active | 1 | 2 1.0|
Necrosis | 4 1 | 3 2.7|
Transitional Epithelium, Hyperplasia | 1 | 3 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
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---------- END OF REPORT ----------
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