TDMS Study 05053-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/08/94
EXP: 05053 BROMOFORM TIME: 01:18:09
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 55130
CONT: N01ES2803301 CAS: 75-25-2
PATHOLOGIST: K. MURTHY_____
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/08/94
EXP: 05053 BROMOFORM TIME: 01:18:09
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 55130
CONT: N01ES2803301 CAS: 75-25-2
PATHOLOGIST: K. MURTHY_____
BROMOFORM
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE 46 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 198 377 429 483 491 514 524 575 586 610 |
| 611 621 632 658 679 688 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.1 G/KG 46 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 337 537 600 607 621 622 629 632 642 649 |
| 649 659 660 663 679 680 694 714 714 721 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.2 G/KG 46 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 39 CENSORED DEATHS 0 TERMINAL 11 |
| |
| UNCENSORED DEATHS |
| 229 236 250 275 299 303 303 356 363 393 |
| 499 527 533 591 600 601 603 616 636 638 |
| 639 642 642 642 643 644 649 649 664 665 |
| 666 670 670 672 687 714 715 716 723 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
BROMOFORM
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 734 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE 46 | 100.0 100.0 98.0 98.0 96.0 92.0 86.0 82.0 72.0 68.0 |
| | |
| | |
|0.1 G/KG 46| 100.0 100.0 100.0 98.0 98.0 98.0 96.0 94.0 72.0 60.0 |
| | |
| | |
|0.2 G/KG 46| 100.0 100.0 94.0 82.0 80.0 80.0 74.0 66.0 40.0 22.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 46 0.1 G/KG 46 0.2 G/KG 46 |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 68.0% 60.0% 22.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.771 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 542.3 635.5 552.9 |
|NATURAL DEATHS (C) | (32.0) (18.5) (25.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 672.6 694.6 592.7 |
|(STANDARD ERROR) | (16.2) (10.0) (22.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BROMOFORM
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE 46 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 537 610 629 629 630 639 642 651 659 661 |
| 666 671 686 691 701 731 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.1 G/KG 46 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 49 52 128 279 341 524 538 576 577 585 |
| 603 607 618 618 625 628 638 653 677 687 |
| 687 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.2 G/KG 46 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 1 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 319 428 483 543 555 582 602 618 637 640 |
| 663 664 665 713 713 714 718 721 722 722 |
| 725 |
| CENSORED DEATHS |
| 173 |
| |
==================================================================================
BROMOFORM
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 735 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 735 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE 46 | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 98.0 80.0 68.0 |
| | |
| | |
|0.1 G/KG 46| 96.0 94.0 94.0 90.0 90.0 90.0 86.0 78.0 64.0 56.0 |
| | |
| | |
|0.2 G/KG 46| 100.0 100.0 100.0 98.0 98.0 93.9 91.8 85.7 73.5 57.1 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 46 0.1 G/KG 46 0.2 G/KG 46 |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 68.0% 56.0% 57.1% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.329 P=0.150 P=0.358 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 652.1 518.7 626.0 |
|NATURAL DEATHS (C) | (11.0) (44.3) (24.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 708.5 639.8 678.0 |
|(STANDARD ERROR) | ( 6.5) (24.6) (16.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BROMOFORM
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE 46 = 1
0.1 G/KG 46 = 2
0.2 G/KG 46 = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 2
| 1 33 2 1 2
| 3 3 3 1 1 1 2 22
| 3 3 1 1 2 2
90 + 33 1 1
| 1 1 22
| 3 33 1 11 222
| 3 3 1 1 22
P 80 + 3 3
E | 3 3 11 2 2
R | 33 3 1 1 1
C | 33 1 2 1
E 70 + 121
N | 33 212 1
T | 33 3 2 2
| 33 22
S 60 + 2 2
U |
R |
V |
I 50 +
V | 33
A | 3 3
L |
40 + 33
|
|
| 3 3
30 + 3 3
| 33
| 33
| 3 3
20 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 13 obs hidden.
BROMOFORM
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE 46 = 1
0.1 G/KG 46 = 2
0.2 G/KG 46 = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1
|
| 22 3 3 1 1
| 2 2 3 3 1 1
95 +
| 2 2 3 3
| 2 2
| 3 3
90 + 2 2 3 3 1 1
|
P | 2 2 3 3
E | 2 2 3 3 11
R 85 +
C | 3 3 1 1
E | 22
N | 33
T 80 + 2 2 3 11
|
S |
U | 2 2 1 1
R 75 +
V | 3 11 3
I | 22 1 1
V |
A 70 + 1 1
L |
| 2 2 33 1
| 2 2
65 +
| 2 2 33
| 2 2
|
60 +
|
| 2 2 3
| 2 2
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 4 obs hidden.