TDMS Study 05057-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
HC YELLOW 4
NTP Experiment-Test: 05057-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/08/94
Route: DOSED FEED Time: 06:16:55
Facility: TSI Mason Research
Chemical CAS #: 5982043-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05057-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 06:16:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATE 0.5% 1.0%
D 61UF 61LF 61HF
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70
Scheduled Sacrifice 20 20 20
Early Deaths
Dead 4 2 2
Moribund 3 10 5
Survivors
Terminal Sacrifice 43 38 43
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (46) (3) (48)
Inflammation, Chronic 10 (22%) 4 (8%)
Liver (50) (18) (50)
Basophilic Focus 1 (2%)
Clear Cell Focus 2 (4%)
Fatty Change 2 (4%)
Inflammation, Chronic Active 17 (34%) 23 (46%)
Necrosis 4 (8%) 1 (6%) 13 (26%)
Mesentery (2) (1) (1)
Fibrosis 1 (50%)
Inflammation, Chronic Active 1 (50%)
Necrosis 1 (50%)
Pancreas (48) (3) (49)
Inflammation, Chronic 25 (52%) 22 (45%)
Salivary Glands (50) (2) (50)
Inflammation, Chronic 4 (8%)
Inflammation, Chronic Active 33 (66%) 1 (50%) 32 (64%)
Stomach, Forestomach (49) (7) (50)
Acanthosis 1 (2%) 3 (6%)
Hyperkeratosis 1 (2%) 2 (4%)
Hyperplasia, Basal Cell 2 (4%)
Hyperplasia, Pseudoepitheliomatous 1 (2%)
Inflammation, Chronic Active 3 (6%) 1 (14%) 4 (8%)
Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05057-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 06:16:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATE 0.5% 1.0%
D 61UF 61LF 61HF
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (3) (50)
Hyperplasia 3 (6%)
Adrenal Gland, Medulla (49) (3) (47)
Hyperplasia 1 (2%) 1 (2%)
Islets, Pancreatic (49) (3) (49)
Hyperplasia 1 (2%)
Pituitary Gland (42) (45)
Pars Distalis, Hyperplasia 9 (21%) 8 (18%)
Thyroid Gland (48) (49) (50)
Inflammation, Acute 2 (4%)
Inflammation, Chronic 1 (2%) 6 (12%) 6 (12%)
Inflammation, Chronic Active 2 (4%)
C-Cell, Hyperplasia 1 (2%)
Follicle, Cyst 1 (2%) 1 (2%) 1 (2%)
Follicle, Pigmentation 48 (98%) 50 (100%)
Follicular Cell, Hyperplasia 3 (6%) 13 (26%)
Follicular Cell, Pigmentation 49 (100%) 50 (100%)
Interstitium, Pigmentation 46 (94%) 50 (100%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (50) (47) (50)
Angiectasis 2 (4%) 4 (8%)
Cyst 14 (28%) 17 (36%) 23 (46%)
Cyst, Multiple 4 (8%) 4 (9%) 1 (2%)
Hemorrhage 9 (19%) 11 (22%)
Inflammation, Chronic 16 (32%) 4 (9%) 2 (4%)
Mineralization 1 (2%) 2 (4%)
Thrombosis 1 (2%)
Uterus (50) (24) (50)
Endometriosis 1 (2%)
Endometrium, Hydrometra 10 (20%)
Endometrium, Hyperplasia 41 (82%) 12 (50%) 36 (72%)
Endometrium, Metaplasia, Squamous 1 (2%)
Endometrium, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05057-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 06:16:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATE 0.5% 1.0%
D 61UF 61LF 61HF
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (3) (50)
Myelofibrosis 36 (72%) 42 (84%)
Lymph Node (49) (15) (49)
Renal, Hyperplasia, Lymphoid 1 (7%)
Lymph Node, Mesenteric (45) (10) (44)
Infiltration Cellular, Histiocyte 26 (58%) 2 (20%) 23 (52%)
Spleen (49) (17) (50)
Hematopoietic Cell Proliferation 6 (12%) 3 (18%) 2 (4%)
Hyperplasia, Lymphoid 11 (22%) 4 (24%) 3 (6%)
Pigmentation 1 (2%)
Thymus (43) (6) (41)
Cyst 4 (9%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (4) (50)
Joint, Tarsal, Hyperostosis 1 (25%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (5) (50)
Gliosis 1 (20%)
Thalamus, Mineralization 34 (68%) 2 (40%) 19 (38%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (8) (50)
Hemorrhage 3 (6%) 5 (10%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%)
Nose (47) (3) (46)
Inflammation, Acute 9 (19%) 1 (33%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05057-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 06:16:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATE 0.5% 1.0%
D 61UF 61LF 61HF
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (4) (50)
Inflammation, Chronic 45 (90%) 3 (75%) 48 (96%)
Metaplasia, Osseous 1 (2%)
Urinary Bladder (48) (4) (49)
Inflammation, Chronic 43 (90%) 2 (50%) 39 (80%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05057-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 06:16:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATE 0.5% 1.O%
D 61UM 61LM 61HM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70
Scheduled Sacrifice 20 20 20
Early Deaths
Dead 14 10 5
Moribund 8 10 9
Accident 1
Survivors
Terminal Sacrifice 28 29 35
Missing 1
Animals Examined Microscopically 50 49 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (39) (9) (46)
Inflammation, Chronic 3 (8%) 4 (9%)
Intestine Small, Ileum (41) (14) (45)
Hyperplasia, Lymphoid 1 (2%)
Liver (49) (22) (48)
Basophilic Focus 1 (2%)
Clear Cell Focus 1 (2%)
Eosinophilic Focus 1 (2%)
Infarct 1 (5%)
Necrosis 9 (18%) 4 (18%) 2 (4%)
Thrombosis 1 (5%)
Pancreas (45) (16) (49)
Inflammation, Chronic 16 (36%) 1 (6%) 11 (22%)
Vacuolization Cytoplasmic 12 (27%) 2 (13%) 8 (16%)
Duct, Dilatation 1 (2%)
Salivary Glands (50) (17) (49)
Inflammation, Chronic Active 33 (66%) 7 (41%) 21 (43%)
Stomach, Forestomach (46) (19) (48)
Acanthosis 1 (2%)
Diverticulum 1 (2%)
Hyperkeratosis 1 (2%)
Stomach, Glandular (46) (16) (47)
Hyperplasia 1 (6%)
Inflammation, Chronic 9 (20%) 1 (6%) 8 (17%)
Mineralization 2 (4%) 1 (6%) 4 (9%)
Tooth (9) (1) (6)
Dysplasia 9 (100%) 1 (100%) 5 (83%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05057-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 06:16:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATE 0.5% 1.O%
D 61UM 61LM 61HM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (17) (49)
Abscess 1 (2%)
Inflammation, Chronic 8 (16%) 7 (14%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (17) (48)
Hyperplasia 7 (14%) 1 (6%) 7 (15%)
Adrenal Gland, Medulla (50) (16) (47)
Hyperplasia 1 (2%) 2 (4%)
Islets, Pancreatic (45) (15) (49)
Hyperplasia 8 (18%)
Pituitary Gland (38) (13) (40)
Pars Distalis, Cyst 1 (3%) 1 (8%)
Pars Distalis, Hyperplasia 10 (26%) 1 (8%) 6 (15%)
Thyroid Gland (47) (48) (49)
Inflammation, Chronic 7 (15%) 29 (59%)
Follicle, Cyst 2 (4%)
Follicle, Inflammation, Acute 1 (2%)
Follicle, Pigmentation 44 (92%) 48 (98%)
Follicular Cell, Hyperplasia 27 (56%) 41 (84%)
Follicular Cell, Pigmentation 44 (92%) 49 (100%)
Interstitium, Pigmentation 42 (88%) 49 (100%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (47) (49)
Granuloma Sperm 1 (2%) 1 (2%)
Inflammation, Chronic Active 16 (32%) 13 (28%) 13 (27%)
Penis (5) (8) (4)
Inflammation, Chronic Active 3 (60%) 4 (50%) 2 (50%)
Preputial Gland (9) (11) (6)
Abscess 3 (33%) 3 (27%) 1 (17%)
Inflammation, Chronic Active 5 (56%) 8 (73%) 4 (67%)
Duct, Dilatation 1 (11%)
Prostate (47) (15) (45)
Inflammation, Chronic Active 34 (72%) 7 (47%) 20 (44%)
Seminal Vesicle (49) (21) (49)
Inflammation, Chronic Active 11 (22%) 4 (19%) 14 (29%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05057-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 06:16:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATE 0.5% 1.O%
D 61UM 61LM 61HM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Testes (50) (17) (49)
Spermatogenic Arrest 1 (6%) 1 (2%)
Germinal Epithelium, Giant Cell 1 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (49) (21) (48)
Depletion Lymphoid 11 (22%) 9 (43%) 5 (10%)
Hematopoietic Cell Proliferation 6 (12%) 6 (29%) 5 (10%)
Hyperplasia, Lymphoid 1 (2%)
Thymus (28) (9) (29)
Cyst 8 (29%) 1 (11%) 4 (14%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (32) (48)
Cyst Epithelial Inclusion 1 (2%)
Inflammation, Chronic Active 8 (16%) 4 (13%) 5 (10%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (39) (48)
Joint, Tarsal, Hyperostosis 17 (34%) 24 (62%) 17 (35%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (18) (49)
Thalamus, Mineralization 29 (58%) 6 (33%) 25 (51%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (29) (49)
Crystals 1 (3%)
Alveolar Epithelium, Hyperplasia 1 (2%) 3 (6%)
Bronchiole, Epithelium, Hyperplasia 1 (2%)
Nose (49) (14) (47)
Cyst 1 (2%)
Inflammation, Acute 6 (12%) 3 (6%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05057-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 06:16:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATE 0.5% 1.O%
D 61UM 61LM 61HM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (22) (49)
Abscess 2 (4%)
Cyst 1 (2%) 3 (6%)
Hydronephrosis 1 (2%) 1 (2%)
Inflammation, Chronic Active 38 (78%) 15 (68%) 44 (90%)
Necrosis 1 (2%)
Vacuolization Cytoplasmic 1 (5%)
Papilla, Mineralization 1 (2%)
Renal Tubule, Mineralization 7 (14%) 2 (9%) 4 (8%)
Urethra (1) (1)
Inflammation, Chronic Active 1 (100%) 1 (100%)
Urinary Bladder (44) (17) (50)
Calculus Micro Observation Only 1 (6%) 1 (2%)
Hemorrhage 2 (12%)
Inflammation, Chronic Active 28 (64%) 5 (29%) 25 (50%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
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