TDMS Study 05057-02 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
HC YELLOW 4
NTP Experiment-Test: 05057-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/08/94
Route: DOSED FEED Time: 06:20:57
Facility: TSI Mason Research
Chemical CAS #: 5982043-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05057-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 06:20:57
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATE 0.5% 1.0%
D 61UF 61LF 61HF
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 70 70
Scheduled Sacrifice 20 20 20
Early Deaths
Dead 4 2 2
Moribund 3 10 5
Survivors
Terminal Sacrifice 43 38 43
Animals Examined Microscopically 50 50 50
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ALIMENTARY SYSTEM
Gallbladder (46) (3) (48)
Intestine Large, Cecum (47) (3) (49)
Intestine Large, Rectum (49) (3) (47)
Intestine Small, Duodenum (46) (9) (50)
Intestine Small, Ileum (45) (11) (48)
Intestine Small, Jejunum (47) (8) (49)
Liver (50) (18) (50)
Hemangioma 1 (2%)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 4 (8%) 6 (33%) 4 (8%)
Hepatocellular Adenoma, Multiple 1 (2%) 2 (11%)
Hepatocholangiocarcinoma 1 (2%)
Mesentery (2) (1) (1)
Pancreas (48) (3) (49)
Salivary Glands (50) (2) (50)
Stomach, Forestomach (49) (7) (50)
Squamous Cell Papilloma 3 (6%) 2 (29%) 1 (2%)
Stomach, Glandular (49) (6) (50)
Tooth (2) (1)
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CARDIOVASCULAR SYSTEM
Heart (50) (4) (50)
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Page 2
NTP Experiment-Test: 05057-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 06:20:57
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATE 0.5% 1.0%
D 61UF 61LF 61HF
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (3) (50)
Pituitary Gland (42) (45)
Pars Distalis, Adenoma 5 (12%) 1 (2%)
Thyroid Gland (48) (49) (50)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (50) (47) (50)
Cystadenoma 2 (4%) 3 (6%)
Granulosa Cell Tumor Benign 1 (2%) 1 (2%)
Teratoma 1 (2%)
Uterus (50) (24) (50)
Polyp Stromal 2 (4%) 1 (4%)
Sarcoma Stromal 1 (2%)
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HEMATOPOIETIC SYSTEM
Bone Marrow (50) (3) (50)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Lymph Node (49) (15) (49)
Lymph Node, Mandibular (45) (5) (45)
Adenocarcinoma, Metastatic, Harderian Gland 1 (2%)
Lymph Node, Mesenteric (45) (10) (44)
Spleen (49) (17) (50)
Hemangiosarcoma, Metastatic, Skeletal Muscle 1 (6%)
Thymus (43) (6) (41)
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INTEGUMENTARY SYSTEM
Mammary Gland (31) (2) (37)
Adenocarcinoma 1 (3%) 1 (50%) 1 (3%)
Skin (50) (40) (50)
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Page 3
NTP Experiment-Test: 05057-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 06:20:57
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATE 0.5% 1.0%
D 61UF 61LF 61HF
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (2) (1) (2)
Hemangiosarcoma 1 (100%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (50%)
Sarcoma 1 (50%)
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NERVOUS SYSTEM
Brain (50) (5) (50)
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RESPIRATORY SYSTEM
Lung (50) (8) (50)
Adenocarcinoma, Metastatic, Harderian Gland 1 (2%)
Adenocarcinoma, Metastatic, Mammary Gland 1 (2%)
Alveolar/Bronchiolar Adenoma 1 (2%) 2 (25%) 1 (2%)
Alveolar/Bronchiolar Adenoma, Multiple 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Mediastinum, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Trachea (49) (3) (50)
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SPECIAL SENSES SYSTEM
Harderian Gland (2) (1) (2)
Adenocarcinoma 1 (50%)
Adenoma 1 (50%) 1 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (4) (50)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Urinary Bladder (48) (4) (49)
Page 4
NTP Experiment-Test: 05057-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 06:20:57
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATE 0.5% 1.0%
D 61UF 61LF 61HF
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Lymphoma Malignant Histiocytic 1 (2%) 1 (2%) 1 (2%)
Lymphoma Malignant Lymphocytic 1 (2%) 3 (6%)
Lymphoma Malignant Mixed 6 (12%) 4 (8%) 5 (10%)
Lymphoma Malignant Undifferentiated Cell 2 (4%) 6 (12%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05057-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 06:20:57
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATE 0.5% 1.0%
D 61UF 61LF 61HF
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 30 24 20
Total Primary Neoplasms 39 30 24
Total Animals with Benign Neoplasms 21 13 11
Total Benign Neoplasms 23 14 13
Total Animals with Malignant Neoplasms 14 15 11
Total Malignant Neoplasms 16 16 11
Total Animals with Metastatic Neoplasms 1 1 3
Total Metastatic Neoplasm 2 1 6
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05057-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 06:20:57
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATE 0.5% 1.O%
D 61UM 61LM 61HM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 70 70
Scheduled Sacrifice 20 20 20
Early Deaths
Dead 14 10 5
Moribund 8 10 9
Accident 1
Survivors
Terminal Sacrifice 28 29 35
Missing 1
Animals Examined Microscopically 50 49 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (39) (9) (46)
Intestine Large, Colon (47) (14) (47)
Intestine Large, Rectum (40) (14) (49)
Adenocarcinoma 1 (2%)
Intestine Small, Ileum (41) (14) (45)
Intestine Small, Jejunum (42) (14) (45)
Liver (49) (22) (48)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%)
Hemangiosarcoma, Multiple 1 (2%)
Hepatocellular Carcinoma 4 (8%) 5 (23%) 8 (17%)
Hepatocellular Carcinoma, Multiple 1 (2%) 2 (9%) 1 (2%)
Hepatocellular Adenoma 8 (16%) 7 (32%) 4 (8%)
Lipoma 1 (2%)
Mesentery (1) (1)
Sarcoma 1 (100%)
Pancreas (45) (16) (49)
Salivary Glands (50) (17) (49)
Stomach, Forestomach (46) (19) (48)
Squamous Cell Papilloma 3 (7%) 2 (11%) 1 (2%)
Stomach, Glandular (46) (16) (47)
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CARDIOVASCULAR SYSTEM
Heart (50) (17) (49)
Sarcoma, Metastatic, Skeletal Muscle 1 (6%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05057-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 06:20:57
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATE 0.5% 1.O%
D 61UM 61LM 61HM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (17) (48)
Adenoma 1 (2%)
Adenoma, Multiple 1 (2%)
Thyroid Gland (47) (48) (49)
Follicular Cell, Adenoma 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Epididymis (50) (47) (49)
Preputial Gland (9) (11) (6)
Fibrosarcoma 1 (11%)
Prostate (47) (15) (45)
Testes (50) (17) (49)
Sertoli Cell Tumor Benign 1 (2%)
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HEMATOPOIETIC SYSTEM
Bone Marrow (49) (16) (47)
Lymph Node (46) (28) (47)
Mediastinal, Pancreatic, Sarcoma, Metastatic,
Skeletal Muscle 1 (4%)
Lymph Node, Mandibular (42) (9) (40)
Lymph Node, Mesenteric (38) (24) (45)
Spleen (49) (21) (48)
Hemangiosarcoma 1 (2%)
Thymus (28) (9) (29)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (32) (48)
Squamous Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (3%)
Subcutaneous Tissue, Fibrosarcoma 5 (10%) 2 (6%) 3 (6%)
Subcutaneous Tissue, Fibrosarcoma, Multiple 1 (2%)
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Page 8
NTP Experiment-Test: 05057-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 06:20:57
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATE 0.5% 1.O%
D 61UM 61LM 61HM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (18) (49)
Meningioma Benign 1 (6%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (29) (49)
Alveolar/Bronchiolar Adenoma 7 (14%) 8 (28%) 5 (10%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 2 (4%) 1 (3%) 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (3%) 2 (4%)
Sarcoma, Metastatic, Skeletal Muscle 1 (3%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (2) (3)
Adenoma 1 (50%) 3 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (22) (49)
Adenocarcinoma 1 (2%)
Sarcoma, Metastatic, Skeletal Muscle 1 (5%)
Urinary Bladder (44) (17) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(49) *(50)
Lymphoma Malignant Mixed 1 (2%)
Lymphoma Malignant Undifferentiated Cell 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 9
NTP Experiment-Test: 05057-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 06:20:57
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATE 0.5% 1.O%
D 61UM 61LM 61HM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 28 23 23
Total Primary Neoplasms 44 31 34
Total Animals with Benign Neoplasms 19 17 13
Total Benign Neoplasms 25 19 16
Total Animals with Malignant Neoplasms 16 12 16
Total Malignant Neoplasms 19 12 18
Total Animals with Metastatic Neoplasms 2 2
Total Metastatic Neoplasm 5 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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