TDMS Study 05057-02 Pathology Tables
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
Facility: TSI Mason Research
Chemical CAS #: 5982043-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 2| 1| 7| 7| 7| 4| 1| 7| 7| 7| 1| 1|
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 3| 3| 3| 6| 7| 3| 3| 3| 5| 7| 3| 3| 3| 7| 7|
| 1| 1| 1| 1| 8| 1| 1| 1| 2| 5| 2| 1| 1| 3| 8| 1| 1| 2| 6| 8| 2| 2| 2| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATE | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
D 61UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + M + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + + + + + + + + |
Inflammation, Chronic | 1 1 1 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + M + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + A + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + M + + + A + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + M A + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + |
Clear Cell Focus | |
Fatty Change | |
Inflammation, Chronic Active | 1 2 1 1 1 1 1 2 1 1 |
Necrosis | 1 1 1 |
__________________________________________________________________________|
Mesentery | M M |
Fibrosis | |
Inflammation, Chronic Active | |
Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + M + + + + + + |
Inflammation, Chronic | 1 1 1 2 1 1 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 1 1 1 2 1 2 1 1 1 1 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + M + + + + + + + + + + + + + + + + + |
Acanthosis | |
Hyperkeratosis | |
Inflammation, Chronic Active | 1 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + A + + + + + + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + M + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + M + + + + + + |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 2| 1| 7| 7| 7| 4| 1| 7| 7| 7| 1| 1|
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 3| 3| 3| 6| 7| 3| 3| 3| 5| 7| 3| 3| 3| 7| 7|
| 1| 1| 1| 1| 8| 1| 1| 1| 2| 5| 2| 1| 1| 3| 8| 1| 1| 2| 6| 8| 2| 2| 2| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATE | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
D 61UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + M + + M + + I M + M + + + + M M + M |
__________________________________________________________________________|
Pituitary Gland | + M M + + M + + + + M + + + + M + M + |
Pars Distalis, Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + M + + + + + + + + |
Inflammation, Chronic | 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + |
Cyst | 2 3 3 3 3 4 |
Cyst, Multiple | 3 3 3 |
Inflammation, Chronic | 2 2 2 2 2 1 1 2 1 |
__________________________________________________________________________|
Oviduct | A |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + |
Endometriosis | |
Endometrium, Hyperplasia | 2 1 3 2 2 2 3 2 2 3 2 1 3 3 4 3 4 |
Endometrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + |
Myelofibrosis | 2 3 2 1 1 1 2 2 3 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + M + + + M + + |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + A + + + + + + |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + M + + + + + + |
Cyst | 1 1 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M M M + + + + + + M + + + + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 2| 1| 7| 7| 7| 4| 1| 7| 7| 7| 1| 1|
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 3| 3| 3| 6| 7| 3| 3| 3| 5| 7| 3| 3| 3| 7| 7|
| 1| 1| 1| 1| 8| 1| 1| 1| 2| 5| 2| 1| 1| 3| 8| 1| 1| 2| 6| 8| 2| 2| 2| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATE | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
D 61UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + |
Hemorrhage | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + M + + + + M + + + |
Inflammation, Acute | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 1 2 1 1 1 1 1 2 1 1 2 1 1 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + |
Inflammation, Chronic | 1 1 2 1 1 1 1 1 2 2 1 2 2 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 1| 7| 5| 4| 1| 1| 7| 7| 7| 4| 1|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 5| 7| 7| 3| 3| 3| 6| 7|
| 2| 2| 2| 2| 6| 2| 2| 2| 3| 6| 2| 2| 2| 2| 7| 2| 2| 6| 8| 8| 2| 2| 2| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATE | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
D 61UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + M + + + + + + M + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + A + M + + |
Inflammation, Chronic | 1 1 1 1 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + M + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + M + + + + + + + + A M + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + M + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + |
Clear Cell Focus | 1 1 |
Fatty Change | 1 |
Inflammation, Chronic Active | 1 1 1 |
Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + M |
Fibrosis | 2 |
Inflammation, Chronic Active | |
Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 1 1 1 2 3 2 1 1 1 2 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + |
Acanthosis | 1 |
Hyperkeratosis | 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 1| 7| 5| 4| 1| 1| 7| 7| 7| 4| 1|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 5| 7| 7| 3| 3| 3| 6| 7|
| 2| 2| 2| 2| 6| 2| 2| 2| 3| 6| 2| 2| 2| 2| 7| 2| 2| 6| 8| 8| 2| 2| 2| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATE | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
D 61UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + M M + + M + M M + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + |
Pars Distalis, Hyperplasia | 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + M + + + + + + + + + + |
Inflammation, Chronic | |
Follicle, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + |
Cyst | 4 4 2 |
Cyst, Multiple | 2 |
Inflammation, Chronic | 1 1 1 2 1 2 |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + |
Endometriosis | 3 |
Endometrium, Hyperplasia | 4 3 2 4 2 2 3 2 2 3 2 2 |
Endometrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + |
Myelofibrosis | 2 1 2 2 1 2 1 1 1 3 2 2 |
__________________________________________________________________________|
Lymph Node | I + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | I + + + + + + + M + + M + + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + M + + |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 3 2 |
Hyperplasia, Lymphoid | 4 2 3 2 |
__________________________________________________________________________|
Thymus | + + + + + M + M + + + + + M + + + M |
Cyst | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + M + + M M + + M + M + M M M + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 1| 7| 5| 4| 1| 1| 7| 7| 7| 4| 1|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 5| 7| 7| 3| 3| 3| 6| 7|
| 2| 2| 2| 2| 6| 2| 2| 2| 3| 6| 2| 2| 2| 2| 7| 2| 2| 6| 8| 8| 2| 2| 2| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATE | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
D 61UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + |
Hemorrhage | 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + M + + |
Inflammation, Acute | 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + M + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 2 1 2 1 2 2 2 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 2 1 2 1 1 2 1 2 2 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 1| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 6| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 5| 7| 3| 3| 3| 6| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 5| | |
| 2| 2| 2| 6| 8| 5| 2| 2| 6| 6| 5| 5| 2| 2| 6| 2| 4| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
UNTREATE | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
D 61UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + A + + + + + + | 46 |
Inflammation, Chronic | 1 | 10 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + A + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + | 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + | 50 |
Clear Cell Focus | | 2 1.0|
Fatty Change | 1 | 2 1.0|
Inflammation, Chronic Active | 2 2 1 1 | 17 1.2|
Necrosis | | 4 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fibrosis | | 1 2.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + A + + + + + + | 48 |
Inflammation, Chronic | 1 1 1 1 1 1 1 | 25 1.1|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + | 50 |
Inflammation, Chronic | 1 1 1 1 | 4 1.0|
Inflammation, Chronic Active | 1 1 1 1 1 | 33 1.4|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + | 49 |
Acanthosis | | 1 1.0|
Hyperkeratosis | | 1 1.0|
Inflammation, Chronic Active | 1 | 3 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Tooth | + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 1| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 6| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 5| 7| 3| 3| 3| 6| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 5| | |
| 2| 2| 2| 6| 8| 5| 2| 2| 6| 6| 5| 5| 2| 2| 6| 2| 4| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
UNTREATE | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
D 61UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 1 | 3 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + | 49 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + | 49 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + | 37 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + | 42 |
Pars Distalis, Hyperplasia | 1 2 2 | 9 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + | 48 |
Inflammation, Chronic | | 1 1.0|
Follicle, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + | 50 |
Cyst | 2 2 1 1 4 | 14 2.7|
Cyst, Multiple | | 4 2.8|
Inflammation, Chronic | 2 | 16 1.6|
__________________________________________________________________________|____________|
Oviduct | | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + | 50 |
Endometriosis | | 1 3.0|
Endometrium, Hyperplasia | 2 3 3 3 2 3 3 2 2 1 3 2 | 41 2.5|
Endometrium, Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + | 50 |
Myelofibrosis | 1 2 2 2 2 1 3 1 1 1 | 36 1.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + | 45 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 | 26 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + | 49 |
Hematopoietic Cell Proliferation | 2 2 2 | 6 2.3|
Hyperplasia, Lymphoid | 2 1 1 1 2 | 11 2.2|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + + + | 43 |
Cyst | | 4 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 1| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 6| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 5| 7| 3| 3| 3| 6| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 5| | |
| 2| 2| 2| 6| 8| 5| 2| 2| 6| 6| 5| 5| 2| 2| 6| 2| 4| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
UNTREATE | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
D 61UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + M + + + M M + + + M | 31 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + | 50 |
Thalamus, Mineralization | 1 1 1 1 1 1 | 34 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + | 50 |
Hemorrhage | 1 1 | 3 1.3|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + | 47 |
Inflammation, Acute | 1 1 1 | 9 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + | 50 |
Inflammation, Chronic | 1 1 1 2 1 1 2 1 1 1 1 1 | 45 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + A + + + + + + | 48 |
Inflammation, Chronic | 1 1 2 1 2 1 2 2 1 2 2 1 | 43 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 6| 4| 7| 7| 6| 1| 1| 7| 7| 7| 1| 1|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 0| 5| 3| 3| 1| 7| 5| 3| 3| 6| 7| 7| 3| 3| 3| 7| 7|
| 0| 0| 0| 0| 2| 0| 0| 0| 4| 6| 0| 0| 8| 6| 6| 0| 0| 4| 8| 7| 1| 0| 0| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.5% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
61LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + |
__________________________________________________________________________|
Gallbladder | + |
__________________________________________________________________________|
Intestine Large | + |
__________________________________________________________________________|
Intestine Large, Cecum | + |
__________________________________________________________________________|
Intestine Large, Colon | + |
__________________________________________________________________________|
Intestine Large, Rectum | + |
__________________________________________________________________________|
Intestine Small | + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + |
__________________________________________________________________________|
Liver | + + + + + + + + |
Necrosis | 2 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + |
__________________________________________________________________________|
Salivary Glands | + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach | + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + |
__________________________________________________________________________|
Islets, Pancreatic | + |
__________________________________________________________________________|
Parathyroid Gland | M |
__________________________________________________________________________|
Pituitary Gland | M |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + M + + + + |
Inflammation, Chronic | 1 1 |
Follicle, Cyst | |
Follicle, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 |
Follicular Cell, Hyperplasia | 1 |
Follicular Cell, Pigmentation | 1 1 1 2 2 2 1 1 1 1 1 1 1 2 1 4 1 1 |
Interstitium, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + M + + + + + + |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 6| 4| 7| 7| 6| 1| 1| 7| 7| 7| 1| 1|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 0| 5| 3| 3| 1| 7| 5| 3| 3| 6| 7| 7| 3| 3| 3| 7| 7|
| 0| 0| 0| 0| 2| 0| 0| 0| 4| 6| 0| 0| 8| 6| 6| 0| 0| 4| 8| 7| 1| 0| 0| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.5% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
61LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Angiectasis | |
Cyst | 4 2 2 2 3 1 1 1 |
Cyst, Multiple | 2 |
Hemorrhage | 2 2 2 |
Inflammation, Chronic | 2 |
Mineralization | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + |
Endometrium, Hyperplasia | 3 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + |
__________________________________________________________________________|
Lymph Node | + + + + M + + + + + |
Renal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + |
Infiltration Cellular, Histiocyte | 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + |
Hematopoietic Cell Proliferation | 3 2 |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Thymus | + + M + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + |
Joint, Tarsal, Hyperostosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + |
Gliosis | 2 |
Thalamus, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + |
__________________________________________________________________________|
Nose | + |
Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 6| 4| 7| 7| 6| 1| 1| 7| 7| 7| 1| 1|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 0| 5| 3| 3| 1| 7| 5| 3| 3| 6| 7| 7| 3| 3| 3| 7| 7|
| 0| 0| 0| 0| 2| 0| 0| 0| 4| 6| 0| 0| 8| 6| 6| 0| 0| 4| 8| 7| 1| 0| 0| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.5% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
61LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + |
Inflammation, Chronic | 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 7| 6| 7| 1| 1| 7| 7| 4| 1| 1| 7| 7| 7| 7| 1| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 4| 5| 5| 5| 3| 8| 3| 7| 7| 3| 3| 5| 7| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5|
| 0| 7| 6| 6| 6| 0| 8| 0| 7| 7| 1| 1| 6| 8| 8| 1| 1| 1| 1| 8| 1| 1| 1| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.5% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
61LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | |
__________________________________________________________________________|
Gallbladder | |
__________________________________________________________________________|
Intestine Large | |
__________________________________________________________________________|
Intestine Large, Cecum | |
__________________________________________________________________________|
Intestine Large, Colon | |
__________________________________________________________________________|
Intestine Large, Rectum | |
__________________________________________________________________________|
Intestine Small | + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + |
__________________________________________________________________________|
Liver | + + + + + |
Necrosis | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | |
__________________________________________________________________________|
Salivary Glands | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach | |
__________________________________________________________________________|
Stomach, Forestomach | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
__________________________________________________________________________|
Adrenal Gland, Cortex | |
__________________________________________________________________________|
Adrenal Gland, Medulla | |
__________________________________________________________________________|
Islets, Pancreatic | |
__________________________________________________________________________|
Parathyroid Gland | |
__________________________________________________________________________|
Pituitary Gland | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 2 |
Follicle, Cyst | |
Follicle, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Follicular Cell, Hyperplasia | 1 |
Follicular Cell, Pigmentation | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 |
Interstitium, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | M + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 7| 6| 7| 1| 1| 7| 7| 4| 1| 1| 7| 7| 7| 7| 1| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 4| 5| 5| 5| 3| 8| 3| 7| 7| 3| 3| 5| 7| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5|
| 0| 7| 6| 6| 6| 0| 8| 0| 7| 7| 1| 1| 6| 8| 8| 1| 1| 1| 1| 8| 1| 1| 1| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.5% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
61LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Angiectasis | 1 |
Cyst | 2 2 4 1 1 |
Cyst, Multiple | 2 |
Hemorrhage | 2 2 1 |
Inflammation, Chronic | 1 1 |
Mineralization | |
__________________________________________________________________________|
Uterus | + + + + + |
Endometrium, Hyperplasia | 3 3 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | |
__________________________________________________________________________|
Lymph Node | + + + |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + |
__________________________________________________________________________|
Skin | + + M + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
Joint, Tarsal, Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | |
Gliosis | |
Thalamus, Mineralization | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | |
__________________________________________________________________________|
Nose | |
Inflammation, Acute | |
__________________________________________________________________________|
Trachea | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 7| 6| 7| 1| 1| 7| 7| 4| 1| 1| 7| 7| 7| 7| 1| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 4| 5| 5| 5| 3| 8| 3| 7| 7| 3| 3| 5| 7| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5|
| 0| 7| 6| 6| 6| 0| 8| 0| 7| 7| 1| 1| 6| 8| 8| 1| 1| 1| 1| 8| 1| 1| 1| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.5% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
61LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | |
Inflammation, Chronic | |
__________________________________________________________________________|
Urinary Bladder | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| 7| 7| 7| 6| 1| 7| 7| 7| 4| 1| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 5| 3| 3| 5| 3| 3| 3| 8| 7| 3| 3| 3| 5| 9| 3| 3| 2| 1| 1| | |
| 1| 6| 1| 1| 6| 1| 1| 1| 2| 8| 1| 1| 1| 6| 2| 1| 1| 2| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0.5% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
61LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + | 2 |
__________________________________________________________________________|____________|
Gallbladder | + + | 3 |
__________________________________________________________________________|____________|
Intestine Large | + + | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 3 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 3 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + M + + | 8 |
__________________________________________________________________________|____________|
Liver | + + + + + | 18 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + | 3 |
__________________________________________________________________________|____________|
Salivary Glands | M + | 2 |
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + | 7 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 7 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 6 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + | 3 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + | 3 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 3 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | M M | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + | 49 |
Inflammation, Chronic | 1 | 6 1.2|
Follicle, Cyst | 1 | 1 1.0|
Follicle, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 48 1.0|
Follicular Cell, Hyperplasia | 2 | 3 1.3|
Follicular Cell, Pigmentation | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 | 49 1.2|
Interstitium, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 46 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| 7| 7| 7| 6| 1| 7| 7| 7| 4| 1| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 5| 3| 3| 5| 3| 3| 3| 8| 7| 3| 3| 3| 5| 9| 3| 3| 2| 1| 1| | |
| 1| 6| 1| 1| 6| 1| 1| 1| 2| 8| 1| 1| 1| 6| 2| 1| 1| 2| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0.5% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
61LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + M + + + + | 47 |
Angiectasis | 1 | 2 1.0|
Cyst | 2 2 3 1 | 17 2.0|
Cyst, Multiple | 2 2 | 4 2.0|
Hemorrhage | 2 1 1 | 9 1.7|
Inflammation, Chronic | 1 | 4 1.3|
Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 24 |
Endometrium, Hyperplasia | 3 4 2 2 2 | 12 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 3 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 15 |
Renal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + | 10 |
Infiltration Cellular, Histiocyte | | 2 1.0|
__________________________________________________________________________|____________|
Spleen | + M + + | 17 |
Hematopoietic Cell Proliferation | | 3 2.3|
Hyperplasia, Lymphoid | 1 | 4 1.8|
__________________________________________________________________________|____________|
Thymus | M M + | 6 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + M + + + + | 40 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 4 |
Joint, Tarsal, Hyperostosis | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 5 |
Gliosis | | 1 2.0|
Thalamus, Mineralization | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 8 |
__________________________________________________________________________|____________|
Nose | + + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| 7| 7| 7| 6| 1| 7| 7| 7| 4| 1| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 5| 3| 3| 5| 3| 3| 3| 8| 7| 3| 3| 3| 5| 9| 3| 3| 2| 1| 1| | |
| 1| 6| 1| 1| 6| 1| 1| 1| 2| 8| 1| 1| 1| 6| 2| 1| 1| 2| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0.5% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
61LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Acute | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + | 3 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 4 |
Inflammation, Chronic | 1 | 3 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + | 4 |
Inflammation, Chronic | 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 1| 7| 7| 4| 1| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|
DAY ON TEST | 3| 3| 3| 5| 7| 3| 3| 5| 7| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5|
| 0| 0| 0| 6| 8| 0| 0| 6| 7| 7| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
61HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + M |
__________________________________________________________________________|
Gallbladder | M + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | M + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + |
Basophilic Focus | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 |
Necrosis | 1 1 2 1 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 1 2 1 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 1 1 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + |
Acanthosis | 2 2 |
Hyperkeratosis | 2 |
Hyperplasia, Basal Cell | 1 2 |
Hyperplasia, Pseudoepitheliomatous | 1 |
Inflammation, Chronic Active | 2 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + M + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + M + + M + + M + M + + M + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + |
Pars Distalis, Hyperplasia | 1 1 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 1| 7| 7| 4| 1| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|
DAY ON TEST | 3| 3| 3| 5| 7| 3| 3| 5| 7| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5|
| 0| 0| 0| 6| 8| 0| 0| 6| 7| 7| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
61HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Inflammation, Acute | 1 |
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | |
C-Cell, Hyperplasia | |
Follicle, Cyst | 2 |
Follicle, Pigmentation | 1 2 2 2 1 2 2 1 1 1 1 2 2 1 2 2 1 2 |
Follicular Cell, Hyperplasia | 1 1 2 1 1 |
Follicular Cell, Pigmentation | 1 2 2 2 1 2 2 1 1 1 1 2 2 1 2 2 1 2 |
Interstitium, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + |
Angiectasis | 2 1 |
Cyst | 2 4 3 2 2 3 2 |
Cyst, Multiple | 2 |
Hemorrhage | 3 2 2 2 1 |
Inflammation, Chronic | 1 1 |
Mineralization | 1 2 |
Thrombosis | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + |
Endometrium, Hydrometra | 3 3 1 |
Endometrium, Hyperplasia | 2 2 3 3 1 1 1 1 2 2 2 3 2 2 |
Endometrium, Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + |
Myelofibrosis | 1 2 2 2 2 1 1 1 2 2 1 1 1 1 1 1 2 |
__________________________________________________________________________|
Lymph Node | M + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + M + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | M + + + + + + + M M + + + + + + + + |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + + + + M + + M + + + + + + M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 1| 7| 7| 4| 1| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|
DAY ON TEST | 3| 3| 3| 5| 7| 3| 3| 5| 7| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5|
| 0| 0| 0| 6| 8| 0| 0| 6| 7| 7| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
61HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + |
Thalamus, Mineralization | 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + |
Hemorrhage | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + M M + |
Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 |
Metaplasia, Osseous | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 1| 1| 7| 7| 7| 7| 4| 7| 7| 4| 4| 1| 7| 7| 4| 4| 1| 7| 7| 6| 1| 1|
DAY ON TEST | 3| 3| 3| 7| 7| 3| 3| 3| 3| 5| 3| 2| 5| 5| 7| 3| 3| 5| 5| 7| 3| 3| 1| 7| 7|
| 0| 0| 0| 8| 8| 0| 0| 0| 0| 6| 0| 9| 6| 6| 8| 0| 0| 6| 6| 8| 0| 0| 0| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
1.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
61HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 1 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + M + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + M |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + |
Basophilic Focus | 2 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 |
Necrosis | 1 1 1 1 1 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 1 1 1 1 2 2 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + |
Acanthosis | |
Hyperkeratosis | |
Hyperplasia, Basal Cell | |
Hyperplasia, Pseudoepitheliomatous | |
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + M + M + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + I + I M + I + M + |
__________________________________________________________________________|
Pituitary Gland | M I + + + + + + + M M + + + |
Pars Distalis, Hyperplasia | 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 1| 1| 7| 7| 7| 7| 4| 7| 7| 4| 4| 1| 7| 7| 4| 4| 1| 7| 7| 6| 1| 1|
DAY ON TEST | 3| 3| 3| 7| 7| 3| 3| 3| 3| 5| 3| 2| 5| 5| 7| 3| 3| 5| 5| 7| 3| 3| 1| 7| 7|
| 0| 0| 0| 8| 8| 0| 0| 0| 0| 6| 0| 9| 6| 6| 8| 0| 0| 6| 6| 8| 0| 0| 0| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
1.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
61HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Inflammation, Acute | |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | |
C-Cell, Hyperplasia | |
Follicle, Cyst | |
Follicle, Pigmentation | 1 1 1 1 2 1 2 1 1 1 1 2 2 2 |
Follicular Cell, Hyperplasia | 1 2 |
Follicular Cell, Pigmentation | 1 1 1 1 2 1 2 1 1 1 1 2 2 2 |
Interstitium, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + |
Angiectasis | |
Cyst | 1 2 2 |
Cyst, Multiple | |
Hemorrhage | 1 2 |
Inflammation, Chronic | |
Mineralization | |
Thrombosis | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + |
Endometrium, Hydrometra | 3 |
Endometrium, Hyperplasia | 2 3 3 2 2 2 3 2 3 2 3 |
Endometrium, Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + |
Myelofibrosis | 2 2 1 2 1 2 2 2 2 2 3 2 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + M M + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + I + + M + M + + |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 2 |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + M |
Cyst | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + M M + + + + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 1| 1| 7| 7| 7| 7| 4| 7| 7| 4| 4| 1| 7| 7| 4| 4| 1| 7| 7| 6| 1| 1|
DAY ON TEST | 3| 3| 3| 7| 7| 3| 3| 3| 3| 5| 3| 2| 5| 5| 7| 3| 3| 5| 5| 7| 3| 3| 1| 7| 7|
| 0| 0| 0| 8| 8| 0| 0| 0| 0| 6| 0| 9| 6| 6| 8| 0| 0| 6| 6| 8| 0| 0| 0| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
1.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
61HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + |
Thalamus, Mineralization | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + |
Hemorrhage | 2 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + M + + + M + + |
Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 |
Metaplasia, Osseous | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 2 1 1 1 1 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 7| 5| 1| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 1| 6| 3| 3| 3| 4| 5| 3| 3| 3| 7| 7| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 3| 1| 0| 0| 0| 7| 6| 0| 0| 0| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
1.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
61HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + M + + + + + + + + + + + + + | 48 |
Inflammation, Chronic | | 4 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + M + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + M + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + | 50 |
Basophilic Focus | | 1 2.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 | 23 1.0|
Necrosis | 1 1 1 2 | 13 1.2|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + M + + + + + + + | 49 |
Inflammation, Chronic | 1 2 1 1 1 1 | 22 1.1|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + | 50 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 32 1.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + | 50 |
Acanthosis | 2 | 3 2.0|
Hyperkeratosis | 1 | 2 1.5|
Hyperplasia, Basal Cell | | 2 1.5|
Hyperplasia, Pseudoepitheliomatous | | 1 1.0|
Inflammation, Chronic Active | 1 2 | 4 1.8|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + | 47 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 7| 5| 1| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 1| 6| 3| 3| 3| 4| 5| 3| 3| 3| 7| 7| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 3| 1| 0| 0| 0| 7| 6| 0| 0| 0| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
1.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
61HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + M + + + + + + + | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M I + M + + + M M + M + + M + M | 31 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + | 45 |
Pars Distalis, Hyperplasia | 2 | 8 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + | 50 |
Inflammation, Acute | 1 | 2 1.0|
Inflammation, Chronic | 1 1 1 | 6 1.0|
Inflammation, Chronic Active | 1 1 | 2 1.0|
C-Cell, Hyperplasia | 1 | 1 1.0|
Follicle, Cyst | | 1 2.0|
Follicle, Pigmentation | 1 2 2 2 1 2 2 2 2 2 1 2 2 2 2 2 2 1 | 50 1.6|
Follicular Cell, Hyperplasia | 1 2 1 2 1 1 | 13 1.3|
Follicular Cell, Pigmentation | 1 2 2 2 1 2 2 2 2 2 1 2 2 2 2 2 2 2 | 50 1.6|
Interstitium, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 50 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + | 50 |
Angiectasis | 2 2 | 4 1.8|
Cyst | 3 2 1 2 4 2 4 3 4 1 3 2 3 | 23 2.5|
Cyst, Multiple | | 1 2.0|
Hemorrhage | 2 2 3 3 | 11 2.1|
Inflammation, Chronic | | 2 1.0|
Mineralization | | 2 1.5|
Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + | 50 |
Endometrium, Hydrometra | 3 3 3 2 2 3 | 10 2.6|
Endometrium, Hyperplasia | 3 2 2 2 2 1 2 3 2 3 2 | 36 2.2|
Endometrium, Metaplasia, Squamous | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + | 50 |
Myelofibrosis | 2 2 1 2 1 3 1 2 2 1 1 2 | 42 1.6|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | I + + + + + + + + + M + + + + + + + | 44 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 | 23 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 7| 5| 1| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 1| 6| 3| 3| 3| 4| 5| 3| 3| 3| 7| 7| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 3| 1| 0| 0| 0| 7| 6| 0| 0| 0| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
1.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
61HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + | 50 |
Hematopoietic Cell Proliferation | 3 3 | 2 3.0|
Hyperplasia, Lymphoid | 2 | 3 2.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M + + + + M + + M + + + + + M + + + | 41 |
Cyst | | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + M + M + + M + + + + | 37 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + | 50 |
Thalamus, Mineralization | 1 1 1 1 1 1 1 | 19 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + | 50 |
Hemorrhage | 1 1 | 5 1.2|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + | 46 |
Inflammation, Acute | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + | 50 |
Inflammation, Chronic | 1 1 1 2 1 1 1 1 1 2 1 1 1 1 2 2 1 1 | 48 1.1|
Metaplasia, Osseous | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + M + + + + + + + + + + + + + | 49 |
Inflammation, Chronic | 1 1 1 1 1 1 2 1 1 2 1 1 1 | 39 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 3| 1| 7| 4| 4| 4| 3| 5| 4| 7| 7| 1| 5| 4| 4| 3| 1|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 9| 8| 3| 5| 2| 0| 2| 1| 5| 3| 3| 8| 0| 5| 5| 7| 8|
| 4| 4| 4| 4| 3| 4| 4| 4| 8| 9| 4| 6| 0| 9| 2| 9| 6| 4| 4| 9| 8| 5| 6| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
D 61UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + M + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + A + + M M + M A + + + + M A |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + M + + + + + + M + + + + + A |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + M + + + M + + A |
__________________________________________________________________________|
Intestine Small | + + + + M + + + A + + + + + + + + A |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + M + + + A + + + + A + + + A |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + M + + + A + A M + + + + + A |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + M + + + A + + + + A + + + A |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + |
Clear Cell Focus | X |
Necrosis | 2 1 |
__________________________________________________________________________|
Mesentery | M A |
__________________________________________________________________________|
Pancreas | + + + + A + + + M + + + + + + + + + |
Inflammation, Chronic | 1 1 1 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 1 2 1 1 1 1 1 1 1 2 1 |
__________________________________________________________________________|
Stomach | + + + + A + + + + + + + + + + + + A |
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + M |
Acanthosis | |
Diverticulum | |
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + A |
Inflammation, Chronic | 1 2 1 |
Mineralization | |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + |
Abscess | 1 |
Inflammation, Chronic | 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + M + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 3| 1| 7| 4| 4| 4| 3| 5| 4| 7| 7| 1| 5| 4| 4| 3| 1|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 9| 8| 3| 5| 2| 0| 2| 1| 5| 3| 3| 8| 0| 5| 5| 7| 8|
| 4| 4| 4| 4| 3| 4| 4| 4| 8| 9| 4| 6| 0| 9| 2| 9| 6| 4| 4| 9| 8| 5| 6| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
D 61UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + I M + + M + M M M + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + M I + + M + + + M M M M + + + |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 1 1 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + M + + M + + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + |
Granuloma Sperm | |
Inflammation, Chronic Active | 1 1 1 1 |
__________________________________________________________________________|
Penis | M + + + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + |
Abscess | 4 3 4 |
Inflammation, Chronic Active | 4 |
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 1 1 3 1 1 1 2 2 4 1 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 1 2 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + M |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + M + + + + + + M |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + A I + + + M + A M + + + + M |
__________________________________________________________________________|
Spleen | + + + + A + + + + + + + + + + + + + |
Depletion Lymphoid | 3 2 2 1 2 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + M + + A + M M M M + A M M + + + + |
Cyst | 1 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M + M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + M + + + + + + + |
Cyst Epithelial Inclusion | |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 3| 1| 7| 4| 4| 4| 3| 5| 4| 7| 7| 1| 5| 4| 4| 3| 1|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 9| 8| 3| 5| 2| 0| 2| 1| 5| 3| 3| 8| 0| 5| 5| 7| 8|
| 4| 4| 4| 4| 3| 4| 4| 4| 8| 9| 4| 6| 0| 9| 2| 9| 6| 4| 4| 9| 8| 5| 6| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
D 61UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + |
Joint, Tarsal, Hyperostosis | 4 4 4 4 4 4 4 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + |
Thalamus, Mineralization | 2 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + |
Cyst | |
Inflammation, Acute | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + M + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + |
Abscess | |
Cyst | |
Hydronephrosis | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Necrosis | |
Renal Tubule, Mineralization | 1 1 1 1 2 1 |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urethra | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + A + + + + + A |
Inflammation, Chronic Active | 1 1 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 4| 1| 1| 7| 4| 7| 6| 1| 7| 7| 7| 7| 7| 4| 7| 7| 1| 0|
DAY ON TEST | 3| 3| 3| 2| 4| 5| 2| 5| 8| 8| 2| 5| 3| 9| 8| 3| 3| 3| 3| 2| 5| 3| 3| 8| 5|
| 4| 4| 4| 3| 9| 6| 1| 6| 9| 9| 3| 6| 4| 2| 9| 4| 4| 4| 4| 3| 5| 4| 4| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
D 61UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + + + + + + M + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + A M + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + A + + + + + + + +|
Clear Cell Focus | |
Necrosis | 2 1 1 2 1|
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + M + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 |
Vacuolization Cytoplasmic | 1 1 2 1 1 1 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + A + + + + + + + +|
Acanthosis | 2 |
Diverticulum | 2 |
Hyperkeratosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 |
Mineralization | 1 |
__________________________________________________________________________|
Tooth | + + + + |
Dysplasia | 3 3 2 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + +|
Abscess | |
Inflammation, Chronic | 1 2 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + M + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 4| 1| 1| 7| 4| 7| 6| 1| 7| 7| 7| 7| 7| 4| 7| 7| 1| 0|
DAY ON TEST | 3| 3| 3| 2| 4| 5| 2| 5| 8| 8| 2| 5| 3| 9| 8| 3| 3| 3| 3| 2| 5| 3| 3| 8| 5|
| 4| 4| 4| 3| 9| 6| 1| 6| 9| 9| 3| 6| 4| 2| 9| 4| 4| 4| 4| 3| 5| 4| 4| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
D 61UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 1 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + M + + M + + + + M M + M|
__________________________________________________________________________|
Pituitary Gland | + + M + + M + + + + + + + + + + M|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Inflammation, Chronic Active | 1 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Penis | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + + |
Abscess | |
Inflammation, Chronic Active | 1 2 2 |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Prostate | + + + M M + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 2 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + A + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Hematopoietic Cell Proliferation | 3 3|
__________________________________________________________________________|
Thymus | I + M + + + M + I + + + + M + M +|
Cyst | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 3 |
Inflammation, Chronic Active | 1 2 2 4|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 4| 1| 1| 7| 4| 7| 6| 1| 7| 7| 7| 7| 7| 4| 7| 7| 1| 0|
DAY ON TEST | 3| 3| 3| 2| 4| 5| 2| 5| 8| 8| 2| 5| 3| 9| 8| 3| 3| 3| 3| 2| 5| 3| 3| 8| 5|
| 4| 4| 4| 3| 9| 6| 1| 6| 9| 9| 3| 6| 4| 2| 9| 4| 4| 4| 4| 3| 5| 4| 4| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
D 61UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Hyperostosis | 4 4 4 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + A + + + + + + + +|
Abscess | |
Cyst | |
Hydronephrosis | 2 |
Inflammation, Chronic Active | 1 1 1 2 1 1 1 1 1 2 2 1 1 1|
Necrosis | 2 |
Renal Tubule, Mineralization | |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urethra | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + A + + + + + + + +|
Inflammation, Chronic Active | 2 2 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 6| 4| 2| 1| 1| 4| 7| 6| 2| 0| 7| 7| 7| 1| 1| | |
DAY ON TEST | 3| 3| 3| 3| 0| 9| 5| 2| 8| 4| 5| 3| 1| 4| 6| 3| 3| 3| 8| 9| | |
| 4| 4| 4| 4| 4| 4| 6| 4| 9| 6| 6| 4| 6| 8| 2| 4| 4| 4| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
D 61UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + M + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + A + + M + + + + + + + | 39 |
Inflammation, Chronic | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + A + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + M + + + + A + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + + + + + A M + + + + | 40 |
__________________________________________________________________________|____________|
Intestine Small | + + + + A + + + + A A + + + + | 43 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + A A + + + + | 42 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + A A + + + + | 41 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + A A + + + + | 42 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 49 |
Clear Cell Focus | | 1 |
Necrosis | 1 1 | 9 1.3|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + A + + + + + M + + + + | 45 |
Inflammation, Chronic | 1 1 1 2 | 16 1.1|
Vacuolization Cytoplasmic | 1 1 1 1 | 12 1.2|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 50 |
Inflammation, Chronic Active | 1 1 2 1 1 1 1 | 33 1.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + A + + + + | 46 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + A + + + + | 46 |
Acanthosis | | 1 2.0|
Diverticulum | | 1 2.0|
Hyperkeratosis | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + A + + + + | 46 |
Inflammation, Chronic | 1 1 | 9 1.1|
Mineralization | 1 | 2 1.0|
__________________________________________________________________________|____________|
Tooth | + + + + + | 9 |
Dysplasia | 4 1 1 1 4 | 9 2.6|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 50 |
Abscess | | 1 1.0|
Inflammation, Chronic | 1 1 1 | 8 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 6| 4| 2| 1| 1| 4| 7| 6| 2| 0| 7| 7| 7| 1| 1| | |
DAY ON TEST | 3| 3| 3| 3| 0| 9| 5| 2| 8| 4| 5| 3| 1| 4| 6| 3| 3| 3| 8| 9| | |
| 4| 4| 4| 4| 4| 4| 6| 4| 9| 6| 6| 4| 6| 8| 2| 4| 4| 4| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
D 61UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + | 50 |
Hyperplasia | 2 2 | 7 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + | 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + M + + + + | 45 |
Hyperplasia | 1 2 2 | 8 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | M M M M + I + M M + M M + + M | 27 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + M M | 38 |
Pars Distalis, Cyst | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 2 1 | 10 1.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + M + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 50 |
Granuloma Sperm | 2 | 1 2.0|
Inflammation, Chronic Active | 1 1 1 1 | 16 1.1|
__________________________________________________________________________|____________|
Penis | + + | 5 |
Inflammation, Chronic Active | 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Preputial Gland | + | 9 |
Abscess | | 3 3.7|
Inflammation, Chronic Active | 1 | 5 2.0|
Duct, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | M + + + + + + + + + + + + + + | 47 |
Inflammation, Chronic Active | 1 1 1 1 4 1 3 1 1 | 34 1.4|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + | 49 |
Inflammation, Chronic Active | 1 2 3 1 | 11 1.4|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + M + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + M + + + M + + + + + | 46 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M M + + + M + M + + + | 42 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + M M + + M M + + + + | 38 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 49 |
Depletion Lymphoid | 1 3 3 2 2 | 11 2.1|
Hematopoietic Cell Proliferation | 4 3 3 3 | 6 3.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 6| 4| 2| 1| 1| 4| 7| 6| 2| 0| 7| 7| 7| 1| 1| | |
DAY ON TEST | 3| 3| 3| 3| 0| 9| 5| 2| 8| 4| 5| 3| 1| 4| 6| 3| 3| 3| 8| 9| | |
| 4| 4| 4| 4| 4| 4| 6| 4| 9| 6| 6| 4| 6| 8| 2| 4| 4| 4| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
D 61UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | M + M + A M M + + M M + + + + | 28 |
Cyst | 1 1 | 8 1.1|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 49 |
Cyst Epithelial Inclusion | | 1 3.0|
Inflammation, Chronic Active | 1 1 2 | 8 1.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 50 |
Joint, Tarsal, Hyperostosis | 4 4 4 4 4 | 17 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 50 |
Thalamus, Mineralization | 1 1 1 1 1 | 29 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 50 |
Alveolar Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + M + + + + + + + + + + + | 49 |
Cyst | | 1 1.0|
Inflammation, Acute | 2 3 1 1 | 6 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + M + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 49 |
Abscess | 4 2 | 2 3.0|
Cyst | 1 | 1 1.0|
Hydronephrosis | | 1 2.0|
Inflammation, Chronic Active | 1 1 1 2 1 1 2 4 1 1 1 | 38 1.2|
Necrosis | | 1 2.0|
Renal Tubule, Mineralization | 1 | 7 1.1|
__________________________________________________________________________|____________|
Ureter | + | 1 |
__________________________________________________________________________|____________|
Urethra | + | 1 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 6| 4| 2| 1| 1| 4| 7| 6| 2| 0| 7| 7| 7| 1| 1| | |
DAY ON TEST | 3| 3| 3| 3| 0| 9| 5| 2| 8| 4| 5| 3| 1| 4| 6| 3| 3| 3| 8| 9| | |
| 4| 4| 4| 4| 4| 4| 6| 4| 9| 6| 6| 4| 6| 8| 2| 4| 4| 4| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
D 61UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + + + A + + + + | 44 |
Inflammation, Chronic Active | 1 2 1 1 1 3 1 1 | 28 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 4| 1| 0| 6| 7| 7| 4| 0| 7| 4| 3| 2| 1| 7| 7| 5| 5| 1| 7| 7| 7| 7| 1|
DAY ON TEST | 3| 3| 5| 5| 9| 2| 3| 3| 5| 7| 3| 5| 7| 7| 0| 3| 3| 1| 9| 8| 3| 3| 3| 3| 8|
| 1| 4| 5| 2| 4| 6| 4| 4| 5| 3| 4| 6| 7| 3| 0| 4| 5| 2| 2| 9| 5| 5| 5| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
61LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + M |
__________________________________________________________________________|
Gallbladder | A M + M + + M + |
__________________________________________________________________________|
Intestine Large | + + + A + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | M + + A + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + |
__________________________________________________________________________|
Intestine Small | A + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | M + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | A + + A + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + A + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + |
Infarct | 3 |
Necrosis | 1 3 |
Thrombosis | 4 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + |
Inflammation, Chronic | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + |
Inflammation, Chronic Active | 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + |
Hyperplasia | |
Inflammation, Chronic | 1 |
Mineralization | 1 |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M + M M + M M |
__________________________________________________________________________|
Pituitary Gland | + + + + M M + + |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 4| 1| 0| 6| 7| 7| 4| 0| 7| 4| 3| 2| 1| 7| 7| 5| 5| 1| 7| 7| 7| 7| 1|
DAY ON TEST | 3| 3| 5| 5| 9| 2| 3| 3| 5| 7| 3| 5| 7| 7| 0| 3| 3| 1| 9| 8| 3| 3| 3| 3| 8|
| 1| 4| 5| 2| 4| 6| 4| 4| 5| 3| 4| 6| 7| 3| 0| 4| 5| 2| 2| 9| 5| 5| 5| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
61LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicle, Inflammation, Acute | 1 |
Follicle, Pigmentation | 2 2 1 1 2 2 2 2 2 2 2 1 2 2 2 1 |
Follicular Cell, Hyperplasia | 1 2 1 2 2 1 1 3 |
Follicular Cell, Pigmentation | 2 2 1 2 2 2 2 2 1 1 2 2 1 1 1 1 |
Interstitium, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 1 1 1 1 1 1 |
__________________________________________________________________________|
Penis | + + + + |
Inflammation, Chronic Active | 4 2 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + |
Abscess | |
Inflammation, Chronic Active | 3 2 1 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + |
Inflammation, Chronic Active | 2 4 2 4 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + |
Inflammation, Chronic Active | 1 1 |
__________________________________________________________________________|
Testes | + + + + + + + + |
Spermatogenic Arrest | |
Germinal Epithelium, Giant Cell | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + M + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | M + M M M M + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + M + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + |
Depletion Lymphoid | 2 2 2 3 |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Thymus | + M + + M + + M |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + |
Joint, Tarsal, Hyperostosis | 4 4 4 4 4 4 4 4 4 4 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 4| 1| 0| 6| 7| 7| 4| 0| 7| 4| 3| 2| 1| 7| 7| 5| 5| 1| 7| 7| 7| 7| 1|
DAY ON TEST | 3| 3| 5| 5| 9| 2| 3| 3| 5| 7| 3| 5| 7| 7| 0| 3| 3| 1| 9| 8| 3| 3| 3| 3| 8|
| 1| 4| 5| 2| 4| 6| 4| 4| 5| 3| 4| 6| 7| 3| 0| 4| 5| 2| 2| 9| 5| 5| 5| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
61LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + |
Thalamus, Mineralization | 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + |
Crystals | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + |
Inflammation, Chronic Active | 1 1 2 2 |
Vacuolization Cytoplasmic | |
Renal Tubule, Mineralization | 2 |
__________________________________________________________________________|
Urethra | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + A + + + |
Calculus Micro Observation Only | |
Hemorrhage | 4 |
Inflammation, Chronic Active | 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 4| 1| 1| 1| 7| 7| 7| 4| 3| 7| 7| 7| 4| 1| 7| 4| 5| 7| 1| 7| 7| 3| 2| 1|
DAY ON TEST | 3| 5| 8| 8| 9| 3| 3| 3| 5| 9| 3| 3| 3| 5| 8| 3| 5| 6| 3| 8| 3| 3| 2| 9| 9|
| 5| 6| 9| 9| 0| 5| 5| 5| 6| 9| 5| 6| 6| 6| 9| 6| 5| 7| 6| 9| 6| 6| 8| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
61LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + |
__________________________________________________________________________|
Gallbladder | + + + I |
__________________________________________________________________________|
Intestine Large | + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + |
__________________________________________________________________________|
Intestine Small | + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + |
__________________________________________________________________________|
Liver | + + + + + |
Infarct | |
Necrosis | 4 |
Thrombosis | |
__________________________________________________________________________|
Mesentery | M |
__________________________________________________________________________|
Pancreas | + + + + |
Inflammation, Chronic | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Salivary Glands | + + + + |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Stomach | + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + |
Hyperplasia | |
Inflammation, Chronic | |
Mineralization | |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + M + + |
__________________________________________________________________________|
Parathyroid Gland | + M M + |
__________________________________________________________________________|
Pituitary Gland | + M + + |
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + M + |
Inflammation, Chronic | 1 1 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 4| 1| 1| 1| 7| 7| 7| 4| 3| 7| 7| 7| 4| 1| 7| 4| 5| 7| 1| 7| 7| 3| 2| 1|
DAY ON TEST | 3| 5| 8| 8| 9| 3| 3| 3| 5| 9| 3| 3| 3| 5| 8| 3| 5| 6| 3| 8| 3| 3| 2| 9| 9|
| 5| 6| 9| 9| 0| 5| 5| 5| 6| 9| 5| 6| 6| 6| 9| 6| 5| 7| 6| 9| 6| 6| 8| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
61LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicle, Inflammation, Acute | |
Follicle, Pigmentation | 2 2 2 2 2 2 2 2 1 1 1 1 1 1 |
Follicular Cell, Hyperplasia | 2 2 1 1 1 1 1 1 1 1 1 |
Follicular Cell, Pigmentation | 2 1 2 1 2 1 1 1 1 1 1 1 1 2 |
Interstitium, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 1 1 1 |
__________________________________________________________________________|
Penis | + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + |
Abscess | 4 4 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Prostate | + + + + |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Testes | + + + + |
Spermatogenic Arrest | 1 |
Germinal Epithelium, Giant Cell | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M |
__________________________________________________________________________|
Spleen | + + + + + |
Depletion Lymphoid | 2 1 2 |
Hematopoietic Cell Proliferation | 3 2 2 |
__________________________________________________________________________|
Thymus | M M + M |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M |
__________________________________________________________________________|
Skin | + + + + + + + |
Inflammation, Chronic Active | 1 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + |
Joint, Tarsal, Hyperostosis | 4 4 4 4 4 4 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 4| 1| 1| 1| 7| 7| 7| 4| 3| 7| 7| 7| 4| 1| 7| 4| 5| 7| 1| 7| 7| 3| 2| 1|
DAY ON TEST | 3| 5| 8| 8| 9| 3| 3| 3| 5| 9| 3| 3| 3| 5| 8| 3| 5| 6| 3| 8| 3| 3| 2| 9| 9|
| 5| 6| 9| 9| 0| 5| 5| 5| 6| 9| 5| 6| 6| 6| 9| 6| 5| 7| 6| 9| 6| 6| 8| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
61LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + |
Thalamus, Mineralization | 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + |
Crystals | |
__________________________________________________________________________|
Nose | M + + + |
__________________________________________________________________________|
Trachea | + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + |
Inflammation, Chronic Active | 1 1 1 1 |
Vacuolization Cytoplasmic | |
Renal Tubule, Mineralization | 2 |
__________________________________________________________________________|
Urethra | + |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Urinary Bladder | M + + + + |
Calculus Micro Observation Only | X |
Hemorrhage | 4 |
Inflammation, Chronic Active | 1 4 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
__________________________________________________________________________________________________________________________________
| 6| 7| 4| 4| 1| 7| 7| 4| 6| 7| 7| 6| 2| 4| 1| 6| 7| 7| 3| 1| | |
DAY ON TEST | 5| 3| 5| 0| 6| 3| 3| 5| 0| 3| 3| 8| 7| 5| 8| 7| 3| 3| 8| 8| | |
| 8| 6| 6| 9| 8| 6| 6| 6| 7| 6| 6| 7| 1| 5| 9| 5| 6| 6| 4| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
61LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + A + + + | 15 |
__________________________________________________________________________|____________|
Gallbladder | M A + A + | 9 |
__________________________________________________________________________|____________|
Intestine Large | + A + M + | 14 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + M + | 13 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + M + M + | 14 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + M + | 14 |
__________________________________________________________________________|____________|
Intestine Small | + A + + M + | 15 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + M + + M + | 15 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + M + | 14 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + M + + M + | 14 |
__________________________________________________________________________|____________|
Liver | + + + + + + + | 22 |
Infarct | | 1 3.0|
Necrosis | 1 | 4 2.3|
Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | | |
__________________________________________________________________________|____________|
Pancreas | + M + + M + | 16 |
Inflammation, Chronic | 1 | 1 1.0|
Vacuolization Cytoplasmic | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 17 |
Inflammation, Chronic Active | 1 1 1 | 7 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 19 |
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + A + | 16 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Dysplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 17 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + M + + + | 17 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + M + + + | 17 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + M + + + | 16 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + M + + M + | 15 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M + | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
__________________________________________________________________________________________________________________________________
| 6| 7| 4| 4| 1| 7| 7| 4| 6| 7| 7| 6| 2| 4| 1| 6| 7| 7| 3| 1| | |
DAY ON TEST | 5| 3| 5| 0| 6| 3| 3| 5| 0| 3| 3| 8| 7| 5| 8| 7| 3| 3| 8| 8| | |
| 8| 6| 6| 9| 8| 6| 6| 6| 7| 6| 6| 7| 1| 5| 9| 5| 6| 6| 4| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
61LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + | 13 |
Pars Distalis, Cyst | | 1 1.0|
Pars Distalis, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 48 |
Inflammation, Chronic | 1 1 1 | 7 1.0|
Follicle, Inflammation, Acute | | 1 1.0|
Follicle, Pigmentation | 2 2 1 1 1 2 1 2 1 1 2 2 1 1 | 44 1.6|
Follicular Cell, Hyperplasia | 1 1 1 1 1 1 1 1 | 27 1.3|
Follicular Cell, Pigmentation | 2 2 2 1 1 3 1 2 1 2 2 1 1 2 | 44 1.5|
Interstitium, Pigmentation | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 | 42 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + A + + + + + + + + + + + | 47 |
Inflammation, Chronic Active | 1 1 1 | 13 1.1|
__________________________________________________________________________|____________|
Penis | + + + | 8 |
Inflammation, Chronic Active | 2 | 4 2.8|
__________________________________________________________________________|____________|
Preputial Gland | + + + | 11 |
Abscess | 4 | 3 4.0|
Inflammation, Chronic Active | 1 3 2 | 8 2.1|
__________________________________________________________________________|____________|
Prostate | M A + + + | 15 |
Inflammation, Chronic Active | 2 | 7 2.9|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + | 21 |
Inflammation, Chronic Active | 1 | 4 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + | 17 |
Spermatogenic Arrest | | 1 1.0|
Germinal Epithelium, Giant Cell | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + A + + + | 16 |
__________________________________________________________________________|____________|
Lymph Node | + + M + + + + + A + + | 28 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + A + | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + M + M M + + | 24 |
__________________________________________________________________________|____________|
Spleen | + + M + + + A + + | 21 |
Depletion Lymphoid | 4 3 | 9 2.3|
Hematopoietic Cell Proliferation | 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Thymus | + + M A + | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
__________________________________________________________________________________________________________________________________
| 6| 7| 4| 4| 1| 7| 7| 4| 6| 7| 7| 6| 2| 4| 1| 6| 7| 7| 3| 1| | |
DAY ON TEST | 5| 3| 5| 0| 6| 3| 3| 5| 0| 3| 3| 8| 7| 5| 8| 7| 3| 3| 8| 8| | |
| 8| 6| 6| 9| 8| 6| 6| 6| 7| 6| 6| 7| 1| 5| 9| 5| 6| 6| 4| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
61LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Cyst | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + M + + | 32 |
Inflammation, Chronic Active | 1 | 4 1.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + | 39 |
Joint, Tarsal, Hyperostosis | 4 4 4 3 4 4 4 4 | 24 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 18 |
Thalamus, Mineralization | 1 1 | 6 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 29 |
Crystals | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + M + I + | 14 |
__________________________________________________________________________|____________|
Trachea | + A + + + | 16 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + A + + + + + + | 22 |
Inflammation, Chronic Active | 1 2 1 1 1 1 1 | 15 1.2|
Vacuolization Cytoplasmic | 2 | 1 2.0|
Renal Tubule, Mineralization | | 2 2.0|
__________________________________________________________________________|____________|
Urethra | M | 1 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + A + + A + | 17 |
Calculus Micro Observation Only | | 1 |
Hemorrhage | | 2 4.0|
Inflammation, Chronic Active | | 5 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 1| 7| 6| 3| 2| 1| 7| 7| 7| 7| 2| 7| 7| 4| 4| 1| 7| 7| 7| 7| 3|
DAY ON TEST | 6| 3| 3| 3| 9| 3| 1| 0| 2| 9| 3| 3| 3| 3| 9| 3| 3| 8| 5| 8| 3| 3| 3| 3| 9|
| 8| 0| 0| 0| 0| 0| 7| 8| 0| 0| 0| 0| 0| 0| 7| 1| 0| 4| 5| 9| 0| 0| 1| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.O% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
61HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + M + + + M + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + M + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + M + + + M + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + M + A + + + + + M + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + M + + + + + + + +|
Basophilic Focus | 2 |
Eosinophilic Focus | |
Necrosis | 3 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 |
Vacuolization Cytoplasmic | 1 3 |
Duct, Dilatation | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + M + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + M + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 |
Mineralization | 2 |
__________________________________________________________________________|
Tooth | + + + |
Dysplasia | 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + M + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + M M M M M + M M M M M + + M + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + M M + + + + + + M +|
Pars Distalis, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 1| 7| 6| 3| 2| 1| 7| 7| 7| 7| 2| 7| 7| 4| 4| 1| 7| 7| 7| 7| 3|
DAY ON TEST | 6| 3| 3| 3| 9| 3| 1| 0| 2| 9| 3| 3| 3| 3| 9| 3| 3| 8| 5| 8| 3| 3| 3| 3| 9|
| 8| 0| 0| 0| 0| 0| 7| 8| 0| 0| 0| 0| 0| 0| 7| 1| 0| 4| 5| 9| 0| 0| 1| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.O% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
61HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + M + + + + + + + +|
Inflammation, Chronic | 1 2 2 2 1 1 1 1 1 2 |
Follicle, Cyst | 2 |
Follicle, Pigmentation | 2 3 2 2 2 2 1 2 2 2 2 2 3 2 3 2 2 3 2|
Follicular Cell, Hyperplasia | 1 1 2 1 2 1 1 2 2 2 2 2 1 2 1 2 |
Follicular Cell, Pigmentation | 2 3 2 2 2 2 2 2 2 2 2 2 2 3 2 3 2 2 3 2|
Interstitium, Pigmentation | 2 1 2 2 2 2 1 1 1 2 1 2 2 3 2 2 2 2 3 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + M + + + + + + + + + + + + +|
Granuloma Sperm | 2|
Inflammation, Chronic Active | 1 1 2 1 |
__________________________________________________________________________|
Penis | + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + + |
Abscess | 4 |
Inflammation, Chronic Active | 4 4 |
__________________________________________________________________________|
Prostate | + + M + + + + + + M + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 4 1 1 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Spermatogenic Arrest | |
Germinal Epithelium, Giant Cell | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + M + + + + + + + +|
Depletion Lymphoid | 2 2 |
Hematopoietic Cell Proliferation | 3 4 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | M M + I + + M A + M + + M + + M M + + M M|
Cyst | 1 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + M + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 1| 7| 6| 3| 2| 1| 7| 7| 7| 7| 2| 7| 7| 4| 4| 1| 7| 7| 7| 7| 3|
DAY ON TEST | 6| 3| 3| 3| 9| 3| 1| 0| 2| 9| 3| 3| 3| 3| 9| 3| 3| 8| 5| 8| 3| 3| 3| 3| 9|
| 8| 0| 0| 0| 0| 0| 7| 8| 0| 0| 0| 0| 0| 0| 7| 1| 0| 4| 5| 9| 0| 0| 1| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.O% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
61HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 3 1 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + M + + + + + + + +|
Joint, Tarsal, Hyperostosis | 4 4 4 4 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + M + + + + + + + +|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + M + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 1 |
Bronchiole, Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + M + + + + + + + +|
Inflammation, Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 |
Hydronephrosis | 2 |
Inflammation, Chronic Active | 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1|
Papilla, Mineralization | 2 |
Renal Tubule, Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Inflammation, Chronic Active | 1 1 3 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 4| 1| 1| 7| 7| 6| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 4| 1| 7| 7| 4| 4| 1|
DAY ON TEST | 3| 3| 5| 8| 9| 3| 3| 0| 3| 5| 3| 0| 3| 3| 5| 7| 3| 3| 5| 8| 0| 3| 5| 5| 9|
| 0| 0| 5| 9| 0| 0| 0| 2| 1| 5| 1| 1| 1| 1| 5| 9| 1| 1| 5| 9| 8| 1| 5| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.O% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
61HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + M + |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + A + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + A + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + M + + + + A + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + A + |
Basophilic Focus | |
Eosinophilic Focus | |
Necrosis | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A + |
Inflammation, Chronic | 2 1 |
Vacuolization Cytoplasmic | 1 1 1 |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + A + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + A + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + A + |
Inflammation, Chronic | 1 1 |
Mineralization | 1 1 |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + A + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + A + |
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + A + |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + A + |
__________________________________________________________________________|
Parathyroid Gland | I + M + M M M + M M M M + A M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + A + |
Pars Distalis, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 4| 1| 1| 7| 7| 6| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 4| 1| 7| 7| 4| 4| 1|
DAY ON TEST | 3| 3| 5| 8| 9| 3| 3| 0| 3| 5| 3| 0| 3| 3| 5| 7| 3| 3| 5| 8| 0| 3| 5| 5| 9|
| 0| 0| 5| 9| 0| 0| 0| 2| 1| 5| 1| 1| 1| 1| 5| 9| 1| 1| 5| 9| 8| 1| 5| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.O% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
61HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 |
Follicle, Cyst | |
Follicle, Pigmentation | 3 3 2 2 2 3 2 3 3 3 3 2 3 3 3 |
Follicular Cell, Hyperplasia | 2 1 1 2 1 1 1 1 2 2 2 2 2 1 |
Follicular Cell, Pigmentation | 3 3 2 2 2 3 2 3 3 3 3 2 3 3 3 |
Interstitium, Pigmentation | 3 2 2 2 2 3 2 2 2 3 3 2 2 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + |
Granuloma Sperm | |
Inflammation, Chronic Active | 1 1 1 1 1 1 |
__________________________________________________________________________|
Penis | + + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Preputial Gland | |
Abscess | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + I + + + M + + + + + |
Inflammation, Chronic Active | 1 1 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + A + |
Inflammation, Chronic Active | 1 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + A + |
Spermatogenic Arrest | |
Germinal Epithelium, Giant Cell | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + M + + + + + A + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + M + + A + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + M + M A + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + M + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + M + |
Depletion Lymphoid | 3 2 |
Hematopoietic Cell Proliferation | 3 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + M M + + M + M + + M M |
Cyst | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
_____________________________________________________________________________________________________________________
| 7| 7| 4| 1| 1| 7| 7| 6| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 4| 1| 7| 7| 4| 4| 1|
DAY ON TEST | 3| 3| 5| 8| 9| 3| 3| 0| 3| 5| 3| 0| 3| 3| 5| 7| 3| 3| 5| 8| 0| 3| 5| 5| 9|
| 0| 0| 5| 9| 0| 0| 0| 2| 1| 5| 1| 1| 1| 1| 5| 9| 1| 1| 5| 9| 8| 1| 5| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.O% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
61HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + M + + + + + + + |
Joint, Tarsal, Hyperostosis | 3 4 2 4 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + |
Alveolar Epithelium, Hyperplasia | 1 |
Bronchiole, Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + M + + + + + + + |
Inflammation, Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + A + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + A + |
Cyst | |
Hydronephrosis | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Papilla, Mineralization | |
Renal Tubule, Mineralization | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + |
Calculus Micro Observation Only | 2 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
__________________________________________________________________________________________________________________________________
| 6| 7| 4| 1| 1| 7| 7| 7| 4| 4| 7| 7| 7| 4| 1| 7| 5| 7| 7| 4| | |
DAY ON TEST | 4| 3| 5| 9| 9| 3| 3| 3| 5| 4| 3| 3| 3| 0| 9| 3| 6| 3| 3| 5| | |
| 5| 1| 5| 0| 0| 1| 1| 1| 6| 8| 1| 1| 1| 5| 0| 1| 7| 1| 1| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.O% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
61HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + M + + | 47 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + M + + + + | 46 |
Inflammation, Chronic | 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + M + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | M + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + | 48 |
Basophilic Focus | | 1 2.0|
Eosinophilic Focus | 1 | 1 1.0|
Necrosis | 1 | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + M | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + | 49 |
Inflammation, Chronic | 1 1 1 | 11 1.1|
Vacuolization Cytoplasmic | 2 2 2 | 8 1.6|
Duct, Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + | 49 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 | 21 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + | 47 |
Inflammation, Chronic | 1 1 | 8 1.0|
Mineralization | 1 | 4 1.3|
__________________________________________________________________________|____________|
Tooth | + + + | 6 |
Dysplasia | 2 2 2 | 5 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + | 49 |
Inflammation, Chronic | 1 | 7 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + | 48 |
Hyperplasia | 2 1 1 2 | 7 1.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + M + + + | 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
__________________________________________________________________________________________________________________________________
| 6| 7| 4| 1| 1| 7| 7| 7| 4| 4| 7| 7| 7| 4| 1| 7| 5| 7| 7| 4| | |
DAY ON TEST | 4| 3| 5| 9| 9| 3| 3| 3| 5| 4| 3| 3| 3| 0| 9| 3| 6| 3| 3| 5| | |
| 5| 1| 5| 0| 0| 1| 1| 1| 6| 8| 1| 1| 1| 5| 0| 1| 7| 1| 1| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.O% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
61HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + I + + M + + + + M M + | 20 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + M I + + M + + + + | 40 |
Pars Distalis, Hyperplasia | 2 2 | 6 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + | 49 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 | 29 1.1|
Follicle, Cyst | 3 | 2 2.5|
Follicle, Pigmentation | 2 2 2 3 2 2 2 2 2 1 3 2 3 3 | 48 2.3|
Follicular Cell, Hyperplasia | 2 2 1 1 1 2 2 1 1 1 2 | 41 1.5|
Follicular Cell, Pigmentation | 2 2 2 3 2 2 2 2 2 2 3 2 3 3 | 49 2.4|
Interstitium, Pigmentation | 2 2 2 3 2 2 2 2 2 1 3 2 3 3 | 49 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + | 49 |
Granuloma Sperm | | 1 2.0|
Inflammation, Chronic Active | 1 1 1 | 13 1.1|
__________________________________________________________________________|____________|
Penis | + | 4 |
Inflammation, Chronic Active | 3 | 2 2.5|
__________________________________________________________________________|____________|
Preputial Gland | + + | 6 |
Abscess | | 1 4.0|
Inflammation, Chronic Active | 4 3 | 4 3.8|
__________________________________________________________________________|____________|
Prostate | + + M + + + + + + + + + + + | 45 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 | 20 1.2|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + | 49 |
Inflammation, Chronic Active | 1 1 1 | 14 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + | 49 |
Spermatogenic Arrest | 2 | 1 2.0|
Germinal Epithelium, Giant Cell | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + M M + + + + + M + + | 40 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M | 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
__________________________________________________________________________________________________________________________________
| 6| 7| 4| 1| 1| 7| 7| 7| 4| 4| 7| 7| 7| 4| 1| 7| 5| 7| 7| 4| | |
DAY ON TEST | 4| 3| 5| 9| 9| 3| 3| 3| 5| 4| 3| 3| 3| 0| 9| 3| 6| 3| 3| 5| | |
| 5| 1| 5| 0| 0| 1| 1| 1| 6| 8| 1| 1| 1| 5| 0| 1| 7| 1| 1| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.O% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
61HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + | 48 |
Depletion Lymphoid | 2 | 5 2.2|
Hematopoietic Cell Proliferation | 3 | 5 3.2|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M M + + + + + + + M + M + + | 29 |
Cyst | 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + M + + + + + + | 48 |
Inflammation, Chronic Active | 1 1 | 5 1.4|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + | 48 |
Joint, Tarsal, Hyperostosis | 4 4 3 4 4 4 4 | 17 3.7|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + | 49 |
Thalamus, Mineralization | 1 1 1 1 1 1 1 | 25 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + | 49 |
Alveolar Epithelium, Hyperplasia | 1 | 3 1.0|
Bronchiole, Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + M + + + + + + + + + + + + | 47 |
Inflammation, Acute | 1 | 3 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 4 |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + | 49 |
Cyst | 2 | 3 2.0|
Hydronephrosis | | 1 2.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 44 1.1|
Papilla, Mineralization | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05057-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:50:08
__________________________________________________________________________________________________________________________________
| 6| 7| 4| 1| 1| 7| 7| 7| 4| 4| 7| 7| 7| 4| 1| 7| 5| 7| 7| 4| | |
DAY ON TEST | 4| 3| 5| 9| 9| 3| 3| 3| 5| 4| 3| 3| 3| 0| 9| 3| 6| 3| 3| 5| | |
| 5| 1| 5| 0| 0| 1| 1| 1| 6| 8| 1| 1| 1| 5| 0| 1| 7| 1| 1| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.O% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
61HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Mineralization | 1 | 4 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + | 50 |
Calculus Micro Observation Only | | 1 2.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 | 25 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
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---------- END OF REPORT ----------
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