TDMS Study 05057-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/08/94
EXP: 05057 HC YELLOW 4 TIME: 06:34:19
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 56019
CONT: N01ES9561901 CAS: 5982043-8
PATHOLOGIST: R. FLEISCHMAN S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/08/94
EXP: 05057 HC YELLOW 4 TIME: 06:34:19
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 56019
CONT: N01ES9561901 CAS: 5982043-8
PATHOLOGIST: R. FLEISCHMAN S. EUSTIS
HC YELLOW 4
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATED 61UM |
| ---------------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 22 CENSORED DEATHS 20 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 51 62 93 104 146 224 248 322 371 398 |
| 409 420 449 508 519 616 692 694 721 723 |
| 723 723 |
| CENSORED DEATHS |
| 189 189 189 189 189 189 189 189 189 190 |
| 455 455 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5% 61 |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 20 CENSORED DEATHS 21 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 73 94 100 152 168 271 291 328 377 384 |
| 399 409 512 567 592 607 626 658 675 687 |
| CENSORED DEATHS |
| 189 189 189 189 189 189 189 189 190 190 |
| 273 455 455 455 455 456 456 456 456 456 |
| 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.O% 61 |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 14 CENSORED DEATHS 21 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 220 297 308 405 448 484 567 602 617 645 |
| 668 679 701 708 |
| CENSORED DEATHS |
| 189 189 189 190 190 190 190 190 190 190 |
| 394 455 455 455 455 455 455 455 455 455 |
| 456 |
| |
==================================================================================
HC YELLOW 4
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATED | 97.1 92.9 89.5 87.8 81.0 79.4 75.1 75.1 72.9 60.0 |
|61UM | |
| | |
|0.5% 61 | 98.6 92.9 92.9 87.7 80.8 80.8 78.7 74.3 67.7 63.4 |
| | |
| | |
|1.O% 61 | 100.0 100.0 98.3 95.0 93.3 89.5 89.5 85.4 81.2 72.9 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATED 0.5% 61 1.O% 61 |
| 61UM |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 60.0% 63.4% 72.9% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.119N P=0.937N P=0.133N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 418.9 398.5 524.9 |
|NATURAL DEATHS (C) | (50.9) (46.9) (44.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 515.8 512.3 567.7 |
|(STANDARD ERROR) | (28.0) (27.3) (24.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
HC YELLOW 4
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATED 61UF |
| ---------------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 7 CENSORED DEATHS 20 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 263 463 466 532 533 625 634 |
| CENSORED DEATHS |
| 177 177 178 178 178 178 178 178 178 178 |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5% 61 |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 12 CENSORED DEATHS 20 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 192 519 592 647 664 676 682 688 704 711 |
| 718 722 |
| CENSORED DEATHS |
| 177 177 177 177 178 178 178 178 178 178 |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0% 61 |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 7 CENSORED DEATHS 20 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 554 561 578 610 613 647 729 |
| CENSORED DEATHS |
| 177 177 177 177 178 178 178 178 178 178 |
| 456 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
HC YELLOW 4
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATED | 100.0 100.0 98.3 98.3 98.3 94.3 90.3 90.3 86.3 86.3 |
|61UF | |
| | |
|0.5% 61 | 100.0 100.0 98.3 98.3 98.3 98.3 96.3 94.3 90.3 76.3 |
| | |
| | |
|1.0% 61 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 94.0 88.0 86.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATED 0.5% 61 1.0% 61 |
| 61UF |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 86.3% 76.3% 86.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000N P=0.375 P=1.000N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 502.3 626.3 613.1 |
|NATURAL DEATHS (C) | (47.4) (42.9) (22.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 589.2 594.2 600.3 |
|(STANDARD ERROR) | (24.4) (24.4) (23.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
HC YELLOW 4
KAPLAN-MEIER SURVIVAL CURVES
UNTREATED 61UM = 1
0.5% 61 = 2
1.O% 61 = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 3
| 11 2 2 3 3
| 1 1 2
| 1 1 2 33
95 + 3 3
| 1 12 2 3 3
| 1 2 1 2
| 1 1 2 2 3 3
P 90 + 1 2 12 3 3
E |
R | 12 12 3 3
C | 12 2 1
E 85 + 1 1 3 3
N | 2 2 3 3
T | 2 11
| 21 1 2 3 3
S 80 +
U | 1 12 2 33
R | 1 1 3 3
V | 2 2
I 75 + 1 1 33
V | 2 2
A | 21 2 1 3 3
L | 11
70 + 2 2
| 1 1
| 2 2
| 11
65 + 2 2
| 2 2
|
|
60 + 1 1
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.
HC YELLOW 4
KAPLAN-MEIER SURVIVAL CURVES
UNTREATED 61UF = 1
0.5% 61 = 2
1.0% 61 = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100.34 +1 2 1 3
|
| 2 1 1 2 33
|
P 96.33 + 2 3 3 2
E |
R | 1 1 3 2 3 2
C |
E 92.31 + 11 2 2
N |
T | 1 3 1 3 2 2
|
S 88.30 + 11 3 22 3
U |
R | 1 22 1
V |
I 84.29 + 2 2
V |
A | 22
L |
80.27 + 22
|
| 22
|
76.26 + 2 2
|
-+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 3 obs hidden.