TDMS Study 05057-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
HC YELLOW 4
NTP Experiment-Test: 05057-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/08/94
Route: DOSED FEED Time: 04:26:02
Facility: TSI Mason Research
Chemical CAS #: 5982043-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05057-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 04:26:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATE 0.5% 1.0%
D 61UF 61LF 61HF
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70
Scheduled Sacrifice 20 20 20
Early Deaths
Moribund 21 15 15
Dead 2 4 1
Survivors
Terminal Sacrifice 26 30 34
Moribund 1 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (48) (49) (49)
Parasite 1 (2%)
Intestine Large, Colon (48) (47) (47)
Parasite 1 (2%) 1 (2%)
Intestine Large, Rectum (48) (46) (49)
Parasite 2 (4%) 1 (2%)
Liver (50) (50) (50)
Basophilic Focus 37 (74%) 32 (64%) 41 (82%)
Clear Cell Focus 1 (2%) 3 (6%) 2 (4%)
Eosinophilic Focus 1 (2%) 2 (4%)
Fatty Change, Diffuse 7 (14%) 7 (14%) 4 (8%)
Fatty Change, Focal 7 (14%) 2 (4%) 3 (6%)
Hepatodiaphragmatic Nodule 4 (8%) 3 (6%) 9 (18%)
Hyperplasia 1 (2%)
Inflammation, Granulomatous 30 (60%) 22 (44%) 27 (54%)
Mixed Cell Focus 6 (12%) 5 (10%) 7 (14%)
Necrosis 3 (6%)
Thrombosis 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 26 (52%) 24 (48%) 32 (64%)
Pancreas (49) (50) (49)
Acinus, Atrophy 1 (2%)
Duct, Hyperplasia 1 (2%)
Stomach, Forestomach (50) (48) (50)
Acanthosis 1 (2%) 7 (15%) 4 (8%)
Hyperkeratosis 2 (4%) 4 (8%) 2 (4%)
Mineralization 1 (2%)
Necrosis 1 (2%)
Ulcer 2 (4%) 1 (2%)
Stomach, Glandular (50) (50) (50)
Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05057-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 04:26:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATE 0.5% 1.0%
D 61UF 61LF 61HF
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Cardiomyopathy 23 (46%) 28 (56%) 23 (46%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (49) (50)
Hyperplasia 1 (2%) 2 (4%) 2 (4%)
Adrenal Gland, Medulla (49) (46) (49)
Hyperplasia 6 (12%) 3 (7%) 4 (8%)
Pituitary Gland (49) (48) (49)
Hyperplasia 1 (2%)
Pars Distalis, Angiectasis 29 (59%) 28 (58%) 22 (45%)
Pars Distalis, Cyst 5 (10%) 5 (10%) 9 (18%)
Pars Distalis, Hyperplasia 11 (22%) 14 (29%) 11 (22%)
Pars Intermedia, Angiectasis 1 (2%)
Pars Intermedia, Cyst 1 (2%)
Thyroid Gland (50) (50) (50)
Hyperplasia 1 (2%)
C-Cell, Hyperplasia 10 (20%) 14 (28%) 11 (22%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (47) (44)
Necrosis 1 (2%) 4 (9%)
Ovary (50) (49) (50)
Cyst 2 (4%) 5 (10%) 3 (6%)
Uterus (48) (50) (50)
Endometrium, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (50) (50) (50)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (2%) 2 (4%)
Lymph Node, Mesenteric (49) (50) (49)
Degeneration, Cystic 1 (2%) 1 (2%)
Infiltration Cellular, Histiocyte 2 (4%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05057-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 04:26:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATE 0.5% 1.0%
D 61UF 61LF 61HF
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Spleen (50) (49) (50)
Fibrosis 1 (2%) 2 (4%)
Hematopoietic Cell Proliferation 30 (60%) 23 (47%) 31 (62%)
Infiltration Cellular, Histiocyte 3 (6%) 1 (2%) 1 (2%)
Pigmentation 28 (56%) 15 (31%) 31 (62%)
Thrombosis 1 (2%)
Thymus (47) (42) (43)
Epithelial Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (37) (47)
Galactocele 14 (29%) 7 (19%) 9 (19%)
Acinus, Hyperplasia 3 (6%) 6 (16%) 5 (11%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Hemorrhage 2 (4%) 1 (2%) 2 (4%)
Spinal Cord (1) (2)
Hemorrhage 1 (50%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Infiltration Cellular, Histiocyte 9 (18%) 16 (32%) 8 (16%)
Alveolar Epithelium, Hyperplasia 3 (6%)
Nose (50) (49) (48)
Fungus 1 (2%)
Inflammation, Acute 2 (4%) 2 (4%) 4 (8%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (12) (8) (17)
Hemorrhage 1 (8%) 1 (6%)
Inflammation, Acute 2 (17%) 2 (25%)
Lens, Cataract 5 (42%) 7 (88%) 8 (47%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05057-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 04:26:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATE 0.5% 1.0%
D 61UF 61LF 61HF
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Retina, Atrophy 1 (8%) 1 (13%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50)
Cyst 1 (2%)
Nephropathy 37 (76%) 44 (88%) 41 (82%)
Urinary Bladder (48) (48) (50)
Inflammation, Chronic Active 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05057-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 04:26:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATE 0.25% 0.5%
D 61 UM 61LM 61HM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70
Scheduled Sacrifice 19 20 20
Early Deaths
Moribund 24 17 18
Dead 6 4 3
Survivors
Terminal Sacrifice 21 29 28
Wrong Sex 1
Animals Examined Microscopically 50 50 49
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (47) (48) (46)
Parasite 1 (2%)
Intestine Large, Colon (48) (44) (45)
Diverticulum 1 (2%)
Parasite 4 (8%) 5 (11%)
Intestine Large, Rectum (47) (47) (47)
Parasite 1 (2%) 2 (4%)
Thrombosis 1 (2%)
Liver (50) (50) (49)
Angiectasis 4 (8%) 1 (2%) 4 (8%)
Angiectasis, Focal 1 (2%) 1 (2%)
Basophilic Focus 17 (34%) 21 (42%) 16 (33%)
Clear Cell Focus 6 (12%) 5 (10%) 10 (20%)
Cyst 1 (2%)
Degeneration, Cystic 2 (4%) 3 (6%) 4 (8%)
Eosinophilic Focus 5 (10%) 2 (4%) 6 (12%)
Fatty Change, Diffuse 3 (6%) 1 (2%)
Fatty Change, Focal 9 (18%) 8 (16%) 3 (6%)
Hepatodiaphragmatic Nodule 7 (14%) 4 (8%) 5 (10%)
Hyperplasia, Focal 1 (2%) 1 (2%)
Mixed Cell Focus 1 (2%) 3 (6%) 1 (2%)
Necrosis 1 (2%) 3 (6%) 3 (6%)
Thrombosis 3 (6%) 1 (2%)
Bile Duct, Hyperplasia 34 (68%) 36 (72%) 41 (84%)
Mesentery (3) (5) (1)
Fat, Inflammation, Chronic Active 1 (100%)
Fat, Necrosis 2 (67%) 1 (100%)
Pancreas (50) (48) (48)
Acinus, Atrophy 22 (44%) 21 (44%) 23 (48%)
Acinus, Basophilic Focus 5 (10%) 1 (2%) 3 (6%)
Acinus, Hyperplasia 1 (2%) 3 (6%) 5 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05057-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 04:26:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATE 0.25% 0.5%
D 61 UM 61LM 61HM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Artery, Fibrosis 4 (8%)
Artery, Inflammation, Chronic Active 2 (4%)
Duct, Hyperplasia 1 (2%)
Stomach, Forestomach (50) (48) (49)
Acanthosis 2 (4%) 2 (4%)
Hyperkeratosis 1 (2%) 1 (2%) 1 (2%)
Necrosis 3 (6%) 1 (2%)
Stomach, Glandular (49) (48) (48)
Hyperplasia 1 (2%)
Mineralization 3 (6%) 1 (2%)
Necrosis 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (49)
Cardiomyopathy 33 (66%) 42 (84%) 34 (69%)
Thrombosis 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (48)
Hyperplasia 3 (6%)
Adrenal Gland, Medulla (50) (49) (48)
Hyperplasia 12 (24%) 16 (33%) 14 (29%)
Islets, Pancreatic (48) (47) (48)
Hyperplasia 3 (6%)
Parathyroid Gland (47) (44) (37)
Hyperplasia 2 (4%) 1 (2%) 1 (3%)
Pituitary Gland (45) (49) (49)
Pars Distalis, Angiectasis 8 (18%) 11 (22%) 10 (20%)
Pars Distalis, Cyst 1 (2%) 1 (2%) 3 (6%)
Pars Distalis, Hyperplasia 8 (18%) 13 (27%) 18 (37%)
Pars Intermedia, Cyst 1 (2%)
Thyroid Gland (49) (49) (48)
C-Cell, Hyperplasia 4 (8%) 9 (18%) 6 (13%)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05057-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 04:26:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATE 0.25% 0.5%
D 61 UM 61LM 61HM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (50) (49)
Granuloma Sperm 1 (2%)
Preputial Gland (48) (50) (49)
Inflammation, Chronic Active 11 (23%) 6 (12%) 5 (10%)
Prostate (48) (49) (46)
Epithelium, Hyperplasia 4 (8%) 1 (2%) 2 (4%)
Testes (50) (50) (49)
Interstitial Cell, Hyperplasia 20 (40%) 27 (54%) 29 (59%)
Seminiferous Tubule, Atrophy 34 (68%) 31 (62%) 21 (43%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (50) (50) (49)
Mediastinal, Fibrosis 1 (2%)
Renal, Pigmentation 1 (2%) 1 (2%)
Lymph Node, Mesenteric (49) (50) (47)
Fibrosis 1 (2%)
Infiltration Cellular, Histiocyte 10 (20%) 3 (6%) 7 (15%)
Spleen (50) (50) (48)
Cyst 1 (2%)
Fibrosis 4 (8%) 2 (4%) 5 (10%)
Hematopoietic Cell Proliferation 20 (40%) 12 (24%) 25 (52%)
Thymus (41) (43) (47)
Cyst 1 (2%)
Epithelial Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (28) (18) (26)
Galactocele 2 (7%) 2 (11%) 2 (8%)
Acinus, Hyperplasia 7 (25%) 6 (33%) 5 (19%)
Skin (48) (50) (47)
Acanthosis 1 (2%) 1 (2%)
Cyst Epithelial Inclusion 2 (4%) 3 (6%)
Hyperkeratosis 2 (4%) 2 (4%) 4 (9%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05057-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 04:26:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATE 0.25% 0.5%
D 61 UM 61LM 61HM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (49)
Hemorrhage 2 (4%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49)
Fibrosis 2 (4%) 2 (4%)
Infiltration Cellular, Histiocyte 6 (12%) 6 (12%) 5 (10%)
Inflammation, Acute 2 (4%) 1 (2%)
Metaplasia, Osseous 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (8%) 2 (4%)
Nose (47) (50) (49)
Fungus 2 (4%) 1 (2%) 1 (2%)
Inflammation, Acute 4 (9%) 4 (8%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (6) (4) (2)
Inflammation, Acute 1 (17%)
Eye (6) (6) (12)
Hemorrhage 1 (17%)
Lens, Cataract 4 (67%) 4 (67%) 6 (50%)
Retina, Atrophy 2 (33%) 3 (25%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49)
Cyst 3 (6%) 2 (4%) 4 (8%)
Hydronephrosis 2 (4%)
Nephropathy 49 (98%) 49 (98%) 47 (96%)
Urinary Bladder (48) (48) (47)
Calculus Gross Observation 1 (2%)
Calculus Micro Observation Only 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
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