TDMS Study 05057-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
HC YELLOW 4
NTP Experiment-Test: 05057-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/08/94
Route: DOSED FEED Time: 04:27:24
Facility: TSI Mason Research
Chemical CAS #: 5982043-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05057-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 04:27:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATE 0.5% 1.0%
D 61UF 61LF 61HF
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 70 70
Scheduled Sacrifice 20 20 20
Early Deaths
Moribund 21 15 15
Dead 2 4 1
Survivors
Terminal Sacrifice 26 30 34
Moribund 1 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (48) (49) (49)
Intestine Large, Colon (48) (47) (47)
Intestine Large, Rectum (48) (46) (49)
Intestine Small, Duodenum (49) (48) (49)
Intestine Small, Ileum (49) (47) (50)
Liver (50) (50) (50)
Carcinoma, Metastatic, Ovary 1 (2%)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 1 (2%)
Mesentery (3) (4) (6)
Carcinoma, Metastatic, Ovary 1 (25%)
Pancreas (49) (50) (49)
Acinus, Adenoma 2 (4%) 2 (4%)
Salivary Glands (50) (50) (50)
Stomach, Forestomach (50) (48) (50)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (50) (50)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (49) (50)
Adenoma 1 (2%) 1 (2%)
Adrenal Gland, Medulla (49) (46) (49)
Pheochromocytoma Malignant 1 (2%)
Page 2
NTP Experiment-Test: 05057-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 04:27:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATE 0.5% 1.0%
D 61UF 61LF 61HF
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pheochromocytoma Benign 1 (2%) 3 (7%) 2 (4%)
Islets, Pancreatic (50) (50) (48)
Adenoma 1 (2%) 1 (2%)
Parathyroid Gland (46) (39) (45)
Adenoma 1 (2%) 1 (3%)
Pituitary Gland (49) (48) (49)
Pars Distalis, Adenoma 31 (63%) 31 (65%) 29 (59%)
Pars Distalis, Adenoma, Multiple 2 (4%) 4 (8%) 1 (2%)
Pars Distalis, Carcinoma 1 (2%)
Thyroid Gland (50) (50) (50)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 9 (18%) 7 (14%) 7 (14%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (47) (44)
Adenoma 6 (13%) 5 (11%) 2 (5%)
Carcinoma 2 (5%)
Bilateral, Adenoma 1 (2%)
Ovary (50) (49) (50)
Carcinoma 1 (2%)
Granulosa Cell Tumor Benign 1 (2%)
Uterus (48) (50) (50)
Polyp Stromal 4 (8%) 7 (14%) 12 (24%)
Polyp Stromal, Multiple 1 (2%)
Sarcoma Stromal 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (49)
Lymph Node (50) (50) (50)
Mediastinal, Carcinoma, Metastatic, Ovary 1 (2%)
Mediastinal, Carcinoma, Metastatic, Thyroid
Gland 1 (2%)
Lymph Node, Mandibular (49) (45) (48)
Adenocarcinoma, Metastatic, Mammary Gland 1 (2%)
Lymph Node, Mesenteric (49) (50) (49)
Spleen (50) (49) (50)
Page 3
NTP Experiment-Test: 05057-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 04:27:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATE 0.5% 1.0%
D 61UF 61LF 61HF
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Thymus (47) (42) (43)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (37) (47)
Adenocarcinoma 1 (2%)
Adenoma 3 (6%) 2 (4%)
Fibroadenoma 19 (40%) 16 (43%) 16 (34%)
Fibroadenoma, Multiple 9 (19%) 3 (8%) 2 (4%)
Skin (48) (50) (49)
Basal Cell Carcinoma 1 (2%)
Carcinoma Adenosquamous 1 (2%)
Keratoacanthoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 3 (6%) 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1) (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
Oligodendroglioma Malignant 1 (2%)
Spinal Cord (1) (2)
Neoplasm NOS 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Adenocarcinoma, Metastatic, Mammary Gland 1 (2%)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%) 2 (4%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Carcinoma Adenosquamous, Metastatic, Skin 1 (2%)
Squamous Cell Carcinoma, Metastatic, Nose 1 (2%)
Nose (50) (49) (48)
Squamous Cell Carcinoma 1 (2%)
Trachea (50) (50) (50)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05057-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 04:27:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATE 0.5% 1.0%
D 61UF 61LF 61HF
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (2) (3) (3)
Fibroma 1 (50%)
Squamous Cell Papilloma 1 (33%)
Harderian Gland (9) (4) (15)
Adenoma 1 (11%) 1 (7%)
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50)
Urinary Bladder (48) (48) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 14 (28%) 15 (30%) 10 (20%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05057-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 04:27:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATE 0.5% 1.0%
D 61UF 61LF 61HF
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 49 48
Total Primary Neoplasms 119 106 96
Total Animals with Benign Neoplasms 43 48 43
Total Benign Neoplasms 96 88 83
Total Animals with Malignant Neoplasms 19 18 13
Total Malignant Neoplasms 22 18 13
Total Animals with Metastatic Neoplasms 4 2
Total Metastatic Neoplasm 5 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05057-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 04:27:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATE 0.25% 0.5%
D 61 UM 61LM 61HM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 70 70
Scheduled Sacrifice 19 20 20
Early Deaths
Moribund 24 17 18
Dead 6 4 3
Survivors
Terminal Sacrifice 21 29 28
Wrong Sex 1
Animals Examined Microscopically 50 50 49
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (48) (48) (49)
Intestine Large, Cecum (47) (48) (46)
Intestine Large, Colon (48) (44) (45)
Polyp Adenomatous 1 (2%)
Intestine Small, Duodenum (47) (48) (47)
Intestine Small, Ileum (45) (48) (46)
Intestine Small, Jejunum (46) (47) (46)
Sarcoma 1 (2%)
Liver (50) (50) (49)
Adenocarcinoma, Metastatic, Lung 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hepatocellular Adenoma 1 (2%)
Mesentery (3) (5) (1)
Pancreas (50) (48) (48)
Acinus, Adenoma 1 (2%) 3 (6%) 2 (4%)
Acinus, Adenoma, Multiple 1 (2%) 1 (2%)
Pharynx (1)
Palate, Squamous Cell Papilloma 1 (100%)
Salivary Glands (49) (50) (48)
Sarcoma 1 (2%)
Stomach, Forestomach (50) (48) (49)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Stomach, Glandular (49) (48) (48)
Tongue (3)
Squamous Cell Papilloma 2 (67%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05057-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 04:27:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATE 0.25% 0.5%
D 61 UM 61LM 61HM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (49)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (48)
Carcinoma 1 (2%)
Adrenal Gland, Medulla (50) (49) (48)
Pheochromocytoma Malignant 2 (4%) 1 (2%)
Pheochromocytoma Benign 13 (26%) 11 (22%) 14 (29%)
Bilateral, Pheochromocytoma Benign 6 (12%) 6 (12%) 2 (4%)
Islets, Pancreatic (48) (47) (48)
Adenoma 1 (2%) 4 (9%) 3 (6%)
Parathyroid Gland (47) (44) (37)
Adenoma 2 (5%)
Pituitary Gland (45) (49) (49)
Pars Distalis, Adenoma 17 (38%) 18 (37%) 26 (53%)
Pars Distalis, Adenoma, Multiple 2 (4%) 2 (4%)
Thyroid Gland (49) (49) (48)
C-Cell, Adenoma 6 (12%) 5 (10%) 6 (13%)
C-Cell, Adenoma, Multiple 1 (2%)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (50) (49)
Preputial Gland (48) (50) (49)
Adenoma 8 (17%) 13 (26%) 7 (14%)
Carcinoma 1 (2%)
Bilateral, Adenoma 1 (2%) 1 (2%)
Prostate (48) (49) (46)
Seminal Vesicle (48) (50) (48)
Testes (50) (50) (49)
Bilateral, Interstitial Cell, Adenoma 37 (74%) 40 (80%) 36 (73%)
Interstitial Cell, Adenoma 10 (20%) 3 (6%) 5 (10%)
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Page 8
NTP Experiment-Test: 05057-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 04:27:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATE 0.25% 0.5%
D 61 UM 61LM 61HM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (48)
Lymph Node (50) (50) (49)
Lymph Node, Mandibular (46) (46) (46)
Lymph Node, Mesenteric (49) (50) (47)
Spleen (50) (50) (48)
Sarcoma 1 (2%)
Thymus (41) (43) (47)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (28) (18) (26)
Adenoma 1 (4%) 1 (4%)
Fibroadenoma 3 (11%) 1 (6%)
Skin (48) (50) (47)
Basal Cell Carcinoma 1 (2%)
Keratoacanthoma 1 (2%) 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 5 (10%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (49)
Osteosarcoma 1 (2%)
Skeletal Muscle (1) (2)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (49)
Astrocytoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49)
Adenocarcinoma 1 (2%)
Alveolar/Bronchiolar Adenoma 2 (4%) 1 (2%) 3 (6%)
Carcinoma, Metastatic, Adrenal Gland 1 (2%)
Carcinoma, Metastatic, Preputial Gland 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Page 9
NTP Experiment-Test: 05057-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 04:27:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATE 0.25% 0.5%
D 61 UM 61LM 61HM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 1 (2%)
Mediastinum, Adenocarcinoma, Metastatic, Lung 1 (2%)
Mediastinum, Sarcoma, Metastatic, Salivary
Glands 1 (2%)
Nose (47) (50) (49)
Squamous Cell Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (6) (4) (2)
Squamous Cell Carcinoma 1 (25%)
Squamous Cell Papilloma 1 (17%)
Harderian Gland (1) (1) (6)
Adenoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49)
Adenocarcinoma, Metastatic, Lung 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (48) (48) (47)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(49)
Leukemia Mononuclear 19 (38%) 21 (42%) 16 (33%)
Lymphoma Malignant Undifferentiated Cell 2 (4%) 1 (2%)
Mesothelioma Malignant 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05057-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HC YELLOW 4 Date: 09/08/94
Route: DOSED FEED Time: 04:27:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATE 0.25% 0.5%
D 61 UM 61LM 61HM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 50 48
Total Primary Neoplasms 143 148 136
Total Animals with Benign Neoplasms 49 49 48
Total Benign Neoplasms 115 119 114
Total Animals with Malignant Neoplasms 27 27 19
Total Malignant Neoplasms 28 29 22
Total Animals with Metastatic Neoplasms 4 3 1
Total Metastatic Neoplasm 4 3 3
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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