TDMS Study 05057-01 Pathology Tables
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
Facility: TSI Mason Research
Chemical CAS #: 5982043-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 1| 7| 6| 4| 7| 1| 7| 7| 4| 1| 7| 1| 7| 4| 7| 6| 4| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 0| 6| 8| 3| 4| 6| 3| 8| 2| 1| 6| 8| 3| 8| 3| 6| 3| 4| 6| 2| 3|
| 5| 5| 6| 6| 1| 4| 3| 5| 7| 4| 5| 2| 8| 0| 4| 3| 5| 3| 1| 4| 5| 5| 4| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATE | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
D 61UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + +|
Parasite | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + +|
Parasite | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + +|
Parasite | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X |
Clear Cell Focus | X |
Fatty Change, Diffuse | 2 2 4|
Fatty Change, Focal | 2 2 |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | |
Inflammation, Granulomatous | 2 2 1 1 1 1 1 1 2 2 1 1 1 1 1 |
Mixed Cell Focus | X X |
Bile Duct, Hyperplasia | 2 1 2 2 2 1 2|
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 3 3 |
Mineralization | |
Necrosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 1| 7| 6| 4| 7| 1| 7| 7| 4| 1| 7| 1| 7| 4| 7| 6| 4| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 0| 6| 8| 3| 4| 6| 3| 8| 2| 1| 6| 8| 3| 8| 3| 6| 3| 4| 6| 2| 3|
| 5| 5| 6| 6| 1| 4| 3| 5| 7| 4| 5| 2| 8| 0| 4| 3| 5| 3| 1| 4| 5| 5| 4| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATE | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
D 61UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + M + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 2 3 2 2 2 3 2 2 2 2 2 |
Pars Distalis, Cyst | 2 2|
Pars Distalis, Hyperplasia | 2 2 1 |
Pars Intermedia, Angiectasis | 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + +|
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 3 2 3 3 |
Infiltration Cellular, Histiocyte | 3 |
Pigmentation | 3 3 2 2 2 2 2 3 3 3 2 2 |
__________________________________________________________________________|
Thymus | + + + + + M + + M + + + + + + +|
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + +|
Galactocele | X X X X X |
Acinus, Hyperplasia | 2 4|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 1| 7| 6| 4| 7| 1| 7| 7| 4| 1| 7| 1| 7| 4| 7| 6| 4| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 0| 6| 8| 3| 4| 6| 3| 8| 2| 1| 6| 8| 3| 8| 3| 6| 3| 4| 6| 2| 3|
| 5| 5| 6| 6| 1| 4| 3| 5| 7| 4| 5| 2| 8| 0| 4| 3| 5| 3| 1| 4| 5| 5| 4| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATE | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
D 61UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 2 1 2 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + |
Hemorrhage | |
Inflammation, Acute | 4 |
Lens, Cataract | 2 |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 1 1 2 2 2 1 2 3 1 1 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 4| 7| 6| 4| 7| 1| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 1| 7| 6| 1| 7| 7| 4| 7|
DAY ON TEST | 3| 6| 3| 9| 4| 3| 8| 5| 6| 2| 3| 3| 2| 1| 1| 3| 3| 8| 0| 9| 8| 3| 3| 6| 3|
| 5| 4| 6| 9| 7| 5| 3| 8| 4| 2| 5| 6| 3| 0| 2| 5| 5| 3| 0| 2| 2| 5| 5| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATE | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
D 61UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + +|
Parasite | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
Parasite | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + M + + + + + + + + + +|
Parasite | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X 1 X X X X X X|
Clear Cell Focus | |
Fatty Change, Diffuse | 2 3 |
Fatty Change, Focal | 1 2 1 |
Hepatodiaphragmatic Nodule | |
Hyperplasia | |
Inflammation, Granulomatous | 1 2 1 3 1 1 2 1 |
Mixed Cell Focus | X X X |
Bile Duct, Hyperplasia | 1 3 2 1 2 1 2 2 1 1 2 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
Mineralization | |
Necrosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 1 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 4| 7| 6| 4| 7| 1| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 1| 7| 6| 1| 7| 7| 4| 7|
DAY ON TEST | 3| 6| 3| 9| 4| 3| 8| 5| 6| 2| 3| 3| 2| 1| 1| 3| 3| 8| 0| 9| 8| 3| 3| 6| 3|
| 5| 4| 6| 9| 7| 5| 3| 8| 4| 2| 5| 6| 3| 0| 2| 5| 5| 3| 0| 2| 2| 5| 5| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATE | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
D 61UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 2 2 3 2 |
Pars Distalis, Cyst | 1 X |
Pars Distalis, Hyperplasia | 3 2 2 2 2 |
Pars Intermedia, Angiectasis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + M + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + +|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 2 |
Infiltration Cellular, Histiocyte | 3 3 |
Pigmentation | 3 2 2 3 2 2 2 2 3 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + +|
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + M + + + + + + + + + + + +|
Galactocele | X X X X X X |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 4| 7| 6| 4| 7| 1| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 1| 7| 6| 1| 7| 7| 4| 7|
DAY ON TEST | 3| 6| 3| 9| 4| 3| 8| 5| 6| 2| 3| 3| 2| 1| 1| 3| 3| 8| 0| 9| 8| 3| 3| 6| 3|
| 5| 4| 6| 9| 7| 5| 3| 8| 4| 2| 5| 6| 3| 0| 2| 5| 5| 3| 0| 2| 2| 5| 5| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATE | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
D 61UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + + + + |
Hemorrhage | 1 |
Inflammation, Acute | 2 |
Lens, Cataract | 2 2 3 |
Retina, Atrophy | 2 |
__________________________________________________________________________|
Harderian Gland | + + + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 1 2 3 2 1 1 1 1 2 1 2 2 1 1 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 4| 7| 6| 6| 7| 4| 1| 7| 4| 1| 7| 7| 6| 1| | |
DAY ON TEST | 3| 3| 0| 5| 8| 3| 6| 3| 5| 0| 3| 6| 8| 3| 0| 8| 3| 3| 5| 8| | |
| 5| 5| 2| 0| 2| 5| 4| 6| 8| 0| 5| 4| 3| 5| 9| 3| 5| 5| 8| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
UNTREATE | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
D 61UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + | 48 |
Parasite | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A M + + + + + | 48 |
Parasite | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 48 |
Parasite | 1 | 2 1.5|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + A + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + | 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 50 |
Basophilic Focus | X X X X 1 X X 1 X 2 1 X | 37 1.2|
Clear Cell Focus | | 1 |
Fatty Change, Diffuse | 2 2 | 7 2.4|
Fatty Change, Focal | 2 2 | 7 1.7|
Hepatodiaphragmatic Nodule | X X | 4 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Granulomatous | 1 1 1 1 1 1 1 | 30 1.3|
Mixed Cell Focus | X | 6 |
Bile Duct, Hyperplasia | 2 2 1 1 1 1 1 1 | 26 1.5|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + A + + + + + + | 49 |
Acinus, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 50 |
Acanthosis | | 1 2.0|
Hyperkeratosis | | 2 3.0|
Mineralization | 3 | 1 3.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 50 |
Cardiomyopathy | 2 1 2 1 2 2 | 23 1.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 4| 7| 6| 6| 7| 4| 1| 7| 4| 1| 7| 7| 6| 1| | |
DAY ON TEST | 3| 3| 0| 5| 8| 3| 6| 3| 5| 0| 3| 6| 8| 3| 0| 8| 3| 3| 5| 8| | |
| 5| 5| 2| 0| 2| 5| 4| 6| 8| 0| 5| 4| 3| 5| 9| 3| 5| 5| 8| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
UNTREATE | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
D 61UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + | 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + M + + + + + + | 49 |
Hyperplasia | 2 | 6 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + + + + + | 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + A + + + + + + | 49 |
Pars Distalis, Angiectasis | 2 2 3 2 2 3 3 2 | 29 2.2|
Pars Distalis, Cyst | X | 5 1.7|
Pars Distalis, Hyperplasia | 2 2 2 | 11 2.0|
Pars Intermedia, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 50 |
C-Cell, Hyperplasia | | 10 1.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + | 47 |
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 50 |
Cyst | X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + A + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + | 50 |
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 49 |
Infiltration Cellular, Histiocyte | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 50 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 1 | 30 2.1|
Infiltration Cellular, Histiocyte | | 3 3.0|
Pigmentation | 2 2 2 2 2 2 | 28 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + + | 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 4| 7| 6| 6| 7| 4| 1| 7| 4| 1| 7| 7| 6| 1| | |
DAY ON TEST | 3| 3| 0| 5| 8| 3| 6| 3| 5| 0| 3| 6| 8| 3| 0| 8| 3| 3| 5| 8| | |
| 5| 5| 2| 0| 2| 5| 4| 6| 8| 0| 5| 4| 3| 5| 9| 3| 5| 5| 8| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
UNTREATE | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
D 61UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Epithelial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + | 48 |
Galactocele | X X X | 14 |
Acinus, Hyperplasia | 2 | 3 2.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + M + + + + M + + | 48 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 50 |
Hemorrhage | 2 | 2 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 50 |
Infiltration Cellular, Histiocyte | | 9 1.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 50 |
Inflammation, Acute | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | + + + | 12 |
Hemorrhage | | 1 1.0|
Inflammation, Acute | | 2 3.0|
Lens, Cataract | 2 | 5 2.2|
Retina, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 9 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + A + + + + + + | 49 |
Cyst | X | 1 |
Nephropathy | 3 1 2 2 2 2 2 3 2 | 37 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + A + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 4| 7| 7| 6| 1| 4| 7| 4| 1| 6| 1| 7| 6| 6| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 4| 6| 3| 3| 6| 8| 6| 3| 6| 8| 1| 8| 3| 8| 2| 6| 3| 3| 3| 1| 1|
| 4| 4| 4| 3| 4| 4| 4| 4| 8| 3| 4| 4| 4| 3| 1| 3| 4| 6| 8| 4| 5| 5| 4| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.5% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
61LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + M A|
Parasite | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + + + + + + + A|
Parasite | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + M + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + M + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + M + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X |
Clear Cell Focus | X X |
Eosinophilic Focus | X |
Fatty Change, Diffuse | 3 2 2 |
Fatty Change, Focal | 3 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Granulomatous | 1 1 1 1 1 |
Mixed Cell Focus | X X |
Necrosis | 2|
Thrombosis | |
Bile Duct, Hyperplasia | 1 1 1 2 2 2 1 2 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + +|
Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 |
Hyperkeratosis | 2 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 4| 7| 7| 6| 1| 4| 7| 4| 1| 6| 1| 7| 6| 6| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 4| 6| 3| 3| 6| 8| 6| 3| 6| 8| 1| 8| 3| 8| 2| 6| 3| 3| 3| 1| 1|
| 4| 4| 4| 3| 4| 4| 4| 4| 8| 3| 4| 4| 4| 3| 1| 3| 4| 6| 8| 4| 5| 5| 4| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.5% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
61LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M M + M + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + +|
Pars Distalis, Angiectasis | 2 2 2 2 3 2 3 2 3 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 1 2 2 3 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
C-Cell, Hyperplasia | 2 2 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + M + + + + + +|
Necrosis | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + A|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 |
Infiltration Cellular, Histiocyte | |
Pigmentation | 2 2 2 2 2 |
Thrombosis | |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + M + + + + M + +|
Galactocele | X X X |
Acinus, Hyperplasia | 2 2 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 4| 7| 7| 6| 1| 4| 7| 4| 1| 6| 1| 7| 6| 6| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 4| 6| 3| 3| 6| 8| 6| 3| 6| 8| 1| 8| 3| 8| 2| 6| 3| 3| 3| 1| 1|
| 4| 4| 4| 3| 4| 4| 4| 4| 8| 3| 4| 4| 4| 3| 1| 3| 4| 6| 8| 4| 5| 5| 4| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.5% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
61LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 3 1 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + I + |
Inflammation, Acute | 1 |
Lens, Cataract | 2 2 2 2 |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Nephropathy | 3 1 1 2 2 1 2 1 2 2 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 1| 4| 7| 7| 7| 1| 1| 7| 6| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 1| 4|
DAY ON TEST | 3| 8| 6| 3| 1| 3| 8| 8| 3| 7| 3| 6| 6| 3| 6| 3| 3| 3| 8| 4| 3| 3| 3| 8| 7|
| 5| 3| 4| 4| 0| 5| 2| 3| 5| 2| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.5% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
61LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + +|
Parasite | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + M + + +|
Parasite | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X 1 X 1|
Clear Cell Focus | |
Eosinophilic Focus | |
Fatty Change, Diffuse | 2 2 2 |
Fatty Change, Focal | |
Hepatodiaphragmatic Nodule | X |
Inflammation, Granulomatous | 2 1 1 1 1 1 1 2 1 1 1 1 |
Mixed Cell Focus | X X |
Necrosis | 1 |
Thrombosis | |
Bile Duct, Hyperplasia | 1 2 2 1 1 1 2 1 2 1 1|
__________________________________________________________________________|
Mesentery | +|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + +|
Duct, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + M + + + + M|
Acanthosis | 2 2 2 1 |
Hyperkeratosis | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + I + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 1| 4| 7| 7| 7| 1| 1| 7| 6| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 1| 4|
DAY ON TEST | 3| 8| 6| 3| 1| 3| 8| 8| 3| 7| 3| 6| 6| 3| 6| 3| 3| 3| 8| 4| 3| 3| 3| 8| 7|
| 5| 3| 4| 4| 0| 5| 2| 3| 5| 2| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.5% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
61LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + M M M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 3 2 3 2 2 3 2 2 2 2 |
Pars Distalis, Cyst | X 2 |
Pars Distalis, Hyperplasia | 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
C-Cell, Hyperplasia | 1 2 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + + + + + + + +|
Necrosis | 2 3 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M M + M + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 3 4 |
Infiltration Cellular, Histiocyte | 3 |
Pigmentation | 3 2 3 2 2 |
Thrombosis | 2 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M + M + + + M M M + + + + + M +|
Galactocele | X X |
Acinus, Hyperplasia | 2 4|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 1| 4| 7| 7| 7| 1| 1| 7| 6| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 1| 4|
DAY ON TEST | 3| 8| 6| 3| 1| 3| 8| 8| 3| 7| 3| 6| 6| 3| 6| 3| 3| 3| 8| 4| 3| 3| 3| 8| 7|
| 5| 3| 4| 4| 0| 5| 2| 3| 5| 2| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.5% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
61LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | +|
__________________________________________________________________________|
Eye | + + |
Inflammation, Acute | |
Lens, Cataract | 3 3 |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 2 3 2 1 2 1 2 2 2 1 2 1 2 1 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 4| 7| 1| 7| 7| 1| 6| 6| 7| 7| 4| 7| 1| | |
DAY ON TEST | 3| 6| 3| 3| 1| 3| 3| 6| 1| 8| 3| 1| 8| 6| 1| 3| 3| 6| 3| 8| | |
| 4| 4| 4| 1| 9| 4| 4| 4| 0| 2| 4| 3| 3| 6| 2| 4| 4| 4| 4| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0.5% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
61LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + M + + + + + + | 47 |
Parasite | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + + + + + + + + + + + + | 46 |
Parasite | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + M + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + M + | 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + | 50 |
Basophilic Focus | X 1 X X X X X X X X X | 32 1.0|
Clear Cell Focus | X | 3 |
Eosinophilic Focus | | 1 |
Fatty Change, Diffuse | 4 | 7 2.4|
Fatty Change, Focal | 2 | 2 2.5|
Hepatodiaphragmatic Nodule | | 3 |
Inflammation, Granulomatous | 1 1 1 1 1 | 22 1.1|
Mixed Cell Focus | X | 5 |
Necrosis | 2 | 3 1.7|
Thrombosis | 3 | 1 3.0|
Bile Duct, Hyperplasia | 1 2 2 1 2 | 24 1.5|
__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + | 50 |
Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + | 48 |
Acanthosis | 2 | 7 1.9|
Hyperkeratosis | 2 | 4 2.0|
Ulcer | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + | 50 |
Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + | 50 |
Cardiomyopathy | 2 2 2 1 2 2 2 2 2 2 3 | 28 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 4| 7| 1| 7| 7| 1| 6| 6| 7| 7| 4| 7| 1| | |
DAY ON TEST | 3| 6| 3| 3| 1| 3| 3| 6| 1| 8| 3| 1| 8| 6| 1| 3| 3| 6| 3| 8| | |
| 4| 4| 4| 1| 9| 4| 4| 4| 0| 2| 4| 3| 3| 6| 2| 4| 4| 4| 4| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0.5% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
61LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + M + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + M + | 49 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + M + M + | 46 |
Hyperplasia | 2 2 | 3 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + M + M + | 39 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + M + + | 48 |
Pars Distalis, Angiectasis | 2 2 2 2 2 3 | 28 2.3|
Pars Distalis, Cyst | X X | 5 2.0|
Pars Distalis, Hyperplasia | 2 2 | 14 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + | 50 |
Hyperplasia | | 1 2.0|
C-Cell, Hyperplasia | 2 2 1 1 | 14 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + M + + + + + + | 47 |
Necrosis | 2 | 4 2.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + M + + + + + + | 49 |
Cyst | | 5 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + | 50 |
Endometrium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + M + + + + + + + | 45 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + | 50 |
Degeneration, Cystic | | 1 3.0|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + | 49 |
Fibrosis | | 2 2.5|
Hematopoietic Cell Proliferation | 2 2 2 3 2 3 2 2 2 | 23 2.2|
Infiltration Cellular, Histiocyte | | 1 3.0|
Pigmentation | 2 2 3 2 2 | 15 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 4| 7| 1| 7| 7| 1| 6| 6| 7| 7| 4| 7| 1| | |
DAY ON TEST | 3| 6| 3| 3| 1| 3| 3| 6| 1| 8| 3| 1| 8| 6| 1| 3| 3| 6| 3| 8| | |
| 4| 4| 4| 1| 9| 4| 4| 4| 0| 2| 4| 3| 3| 6| 2| 4| 4| 4| 4| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0.5% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
61LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + + M + + M M + + | 42 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + + + + M M | 37 |
Galactocele | 2 X | 7 2.0|
Acinus, Hyperplasia | | 6 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + | 50 |
Hemorrhage | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + | 50 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 | 16 1.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + M + + | 49 |
Fungus | 4 | 1 4.0|
Inflammation, Acute | 3 1 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 3 |
__________________________________________________________________________|____________|
Eye | + | 8 |
Inflammation, Acute | 4 | 2 2.5|
Lens, Cataract | 4 | 7 2.6|
Retina, Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + | 50 |
Nephropathy | 1 1 2 1 1 1 1 2 2 1 2 2 2 | 44 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + M + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 7| 6| 5| 1| 7| 7| 7| 1| 7| 7| 7| 4| 7| 6| 1| 1| 7| 4| 5|
DAY ON TEST | 3| 1| 7| 4| 6| 3| 3| 5| 3| 8| 3| 3| 3| 8| 3| 3| 3| 6| 3| 4| 8| 8| 3| 6| 5|
| 1| 6| 2| 5| 4| 4| 4| 0| 1| 2| 4| 4| 4| 2| 4| 1| 1| 4| 1| 3| 2| 2| 1| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
61HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + M + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X 1|
Clear Cell Focus | X |
Eosinophilic Focus | |
Fatty Change, Diffuse | 4 |
Fatty Change, Focal | 2 2 |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Granulomatous | 1 2 3 1 1 1 1 1 2 1 2|
Mixed Cell Focus | X X |
Thrombosis | |
Bile Duct, Hyperplasia | 2 2 1 2 2 2 3 1 2 2 2 1|
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + M + + M + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M M + + + + + + + + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 7| 6| 5| 1| 7| 7| 7| 1| 7| 7| 7| 4| 7| 6| 1| 1| 7| 4| 5|
DAY ON TEST | 3| 1| 7| 4| 6| 3| 3| 5| 3| 8| 3| 3| 3| 8| 3| 3| 3| 6| 3| 4| 8| 8| 3| 6| 5|
| 1| 6| 2| 5| 4| 4| 4| 0| 1| 2| 4| 4| 4| 2| 4| 1| 1| 4| 1| 3| 2| 2| 1| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
61HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Angiectasis | 2 3 3 2 2 2 2 |
Pars Distalis, Cyst | X 1 1 X X |
Pars Distalis, Hyperplasia | 2 2 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M + M + M + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + +|
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 |
Infiltration Cellular, Histiocyte | 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 2 2 2 2 3 2 2 2 |
Infiltration Cellular, Histiocyte | |
Pigmentation | 2 3 2 2 2 2 3 2 3 2 |
__________________________________________________________________________|
Thymus | + + + + + M M + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + +|
Galactocele | X X 3|
Acinus, Hyperplasia | 3 1 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 7| 6| 5| 1| 7| 7| 7| 1| 7| 7| 7| 4| 7| 6| 1| 1| 7| 4| 5|
DAY ON TEST | 3| 1| 7| 4| 6| 3| 3| 5| 3| 8| 3| 3| 3| 8| 3| 3| 3| 6| 3| 4| 8| 8| 3| 6| 5|
| 1| 6| 2| 5| 4| 4| 4| 0| 1| 2| 4| 4| 4| 2| 4| 1| 1| 4| 1| 3| 2| 2| 1| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
61HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 3|
__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + M + + + + +|
Inflammation, Acute | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + +|
__________________________________________________________________________|
Eye | + + I + + + + |
Hemorrhage | |
Lens, Cataract | 2 2 2 |
__________________________________________________________________________|
Harderian Gland | + + + + + + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 2 2 2 1 1 1 2 1 1 2 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 4| 4| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 6| 6| 8| 3| 3| 3| 3| 9| 3| 2| 6| 2| 1| 3| 2| 8| 2| 1|
| 1| 1| 1| 1| 2| 1| 2| 4| 4| 6| 1| 1| 1| 1| 2| 0| 9| 4| 9| 0| 0| 9| 3| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
1.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
61HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X|
Clear Cell Focus | |
Eosinophilic Focus | X |
Fatty Change, Diffuse | 2 2 |
Fatty Change, Focal | 3|
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Granulomatous | 3 1 1 1 1 1 1 1 1 2 1 1|
Mixed Cell Focus | X X X |
Thrombosis | X |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 1 2 2 1 2 2|
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2|
Hyperkeratosis | 2 3|
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 4| 4| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 6| 6| 8| 3| 3| 3| 3| 9| 3| 2| 6| 2| 1| 3| 2| 8| 2| 1|
| 1| 1| 1| 1| 2| 1| 2| 4| 4| 6| 1| 1| 1| 1| 2| 0| 9| 4| 9| 0| 0| 9| 3| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
1.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
61HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Angiectasis | 3 3 2 2 2 2 3 2 2 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 2 2 2 3 2 1 |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + + + + M + + + + + + + + + M|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Infiltration Cellular, | |
Histiocyte | 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 4 2 2 2 2 3 2 2 2 2 2 2 2|
Infiltration Cellular, Histiocyte | 3 |
Pigmentation | 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + M + + + + + +|
Galactocele | X X X X X |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 4| 4| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 6| 6| 8| 3| 3| 3| 3| 9| 3| 2| 6| 2| 1| 3| 2| 8| 2| 1|
| 1| 1| 1| 1| 2| 1| 2| 4| 4| 6| 1| 1| 1| 1| 2| 0| 9| 4| 9| 0| 0| 9| 3| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
1.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
61HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + M + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + +|
Hemorrhage | |
Lens, Cataract | 3 2 |
__________________________________________________________________________|
Harderian Gland | + + + + +|
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 2 1 1 1 1 1 1 1 2 1 1 1 3 1 1 1 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 7| 1| 7| 6| 4| 7| 4| 4| 1| 7| 4| 1| 1| 6| 4| | |
DAY ON TEST | 8| 2| 2| 2| 2| 2| 8| 2| 3| 9| 2| 6| 6| 8| 2| 6| 8| 8| 5| 6| | |
| 2| 9| 9| 9| 9| 9| 2| 9| 2| 7| 9| 4| 4| 2| 9| 4| 3| 2| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
1.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
61HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + | 50 |
Basophilic Focus | X X X X X X 1 X X X | 41 1.0|
Clear Cell Focus | X | 2 |
Eosinophilic Focus | X | 2 |
Fatty Change, Diffuse | 4 | 4 3.0|
Fatty Change, Focal | | 3 2.3|
Hepatodiaphragmatic Nodule | X X X | 9 |
Inflammation, Granulomatous | 1 1 2 2 | 27 1.4|
Mixed Cell Focus | X X | 7 |
Thrombosis | | 1 |
Bile Duct, Hyperplasia | 2 2 2 2 2 1 2 | 32 1.8|
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + | 50 |
Acanthosis | 2 2 | 4 2.0|
Hyperkeratosis | | 2 2.5|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + | 50 |
Cardiomyopathy | 2 2 1 2 2 | 23 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + | 50 |
Hyperplasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 7| 1| 7| 6| 4| 7| 4| 4| 1| 7| 4| 1| 1| 6| 4| | |
DAY ON TEST | 8| 2| 2| 2| 2| 2| 8| 2| 3| 9| 2| 6| 6| 8| 2| 6| 8| 8| 5| 6| | |
| 2| 9| 9| 9| 9| 9| 2| 9| 2| 7| 9| 4| 4| 2| 9| 4| 3| 2| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
1.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
61HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 1 | 4 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + | 49 |
Hyperplasia | | 1 2.0|
Pars Distalis, Angiectasis | 2 2 2 2 3 3 | 22 2.3|
Pars Distalis, Cyst | X 1 | 9 1.0|
Pars Distalis, Hyperplasia | 2 | 11 2.0|
Pars Intermedia, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + | 50 |
C-Cell, Hyperplasia | 1 1 1 | 11 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + | 50 |
Cyst | | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + | 50 |
Endometrium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + | 50 |
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + + + | 49 |
Degeneration, Cystic | | 1 3.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + | 50 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 | 31 2.2|
Infiltration Cellular, Histiocyte | | 1 3.0|
Pigmentation | 2 2 2 2 2 2 | 31 2.1|
__________________________________________________________________________|____________|
Thymus | M + + + + + M + + + + | 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + + + | 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 7| 7| 7| 1| 7| 6| 4| 7| 4| 4| 1| 7| 4| 1| 1| 6| 4| | |
DAY ON TEST | 8| 2| 2| 2| 2| 2| 8| 2| 3| 9| 2| 6| 6| 8| 2| 6| 8| 8| 5| 6| | |
| 2| 9| 9| 9| 9| 9| 2| 9| 2| 7| 9| 4| 4| 2| 9| 4| 3| 2| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
1.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
61HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Galactocele | X | 9 3.0|
Acinus, Hyperplasia | 3 2 | 5 2.4|
__________________________________________________________________________|____________|
Skin | + + + M + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + | 50 |
Hyperostosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + | 50 |
Hemorrhage | | 2 2.5|
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + | 50 |
Infiltration Cellular, Histiocyte | 1 | 8 1.0|
Alveolar Epithelium, Hyperplasia | 2 | 3 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + | 48 |
Inflammation, Acute | 1 2 | 4 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 3 |
__________________________________________________________________________|____________|
Eye | + + + + + + | 17 |
Hemorrhage | 2 | 1 2.0|
Lens, Cataract | 2 2 2 | 8 2.1|
__________________________________________________________________________|____________|
Harderian Gland | + + + + | 15 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + | 50 |
Nephropathy | 1 1 1 2 1 2 2 2 | 41 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + | 50 |
Inflammation, Chronic Active | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 1| 7| 7| 6| 6| 5| 7| 7| 6| 4| 6| 1| 1| 7| 7| 1| 5| 7| 6| 6| 4|
DAY ON TEST | 3| 3| 3| 7| 7| 3| 0| 7| 3| 9| 3| 2| 6| 7| 5| 7| 7| 3| 3| 7| 8| 1| 8| 6| 7|
| 1| 1| 2| 0| 5| 2| 7| 3| 7| 8| 1| 4| 5| 0| 5| 5| 5| 1| 1| 5| 7| 0| 9| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
D 61 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + M + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + A + + + A + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + A + + + |
Parasite | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + A + + + |
Diverticulum | |
Parasite | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + A + + + |
Parasite | 2 |
Thrombosis | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + A + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + A + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + A + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + A + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + |
Angiectasis, Focal | |
Angiectasis | 1 |
Basophilic Focus | X X X X X |
Clear Cell Focus | X X |
Cyst | X |
Degeneration, Cystic | 1 |
Eosinophilic Focus | X |
Fatty Change, Diffuse | 2 |
Fatty Change, Focal | 2 3 1 2 2 |
Hepatodiaphragmatic Nodule | X X X |
Mixed Cell Focus | |
Necrosis | 3 |
Thrombosis | 1 3 2 |
Bile Duct, Hyperplasia | 2 2 2 2 3 2 2 3 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + |
Acinus, Atrophy | 2 2 2 2 2 2 1 2 2 2 2 |
Acinus, Basophilic Focus | X X |
Acinus, Hyperplasia | 2 |
Duct, Hyperplasia | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + |
Acanthosis | |
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + A + + + + + + + |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 1| 7| 7| 6| 6| 5| 7| 7| 6| 4| 6| 1| 1| 7| 7| 1| 5| 7| 6| 6| 4|
DAY ON TEST | 3| 3| 3| 7| 7| 3| 0| 7| 3| 9| 3| 2| 6| 7| 5| 7| 7| 3| 3| 7| 8| 1| 8| 6| 7|
| 1| 1| 2| 0| 5| 2| 7| 3| 7| 8| 1| 4| 5| 0| 5| 5| 5| 1| 1| 5| 7| 0| 9| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
D 61 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Necrosis | 2 2 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 1 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | 2 2 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + A + + + + + + + |
C-Cell, Hyperplasia | 3 2 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + M + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + M + + + + + + + |
Inflammation, Chronic Active | 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + M + + + + + + + |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + M + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + |
Interstitial Cell, Hyperplasia | 2 1 1 2 2 2 |
Seminiferous Tubule, Atrophy | 2 2 4 2 2 2 3 3 3 3 3 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + A + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + |
Renal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + M + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 1| 7| 7| 6| 6| 5| 7| 7| 6| 4| 6| 1| 1| 7| 7| 1| 5| 7| 6| 6| 4|
DAY ON TEST | 3| 3| 3| 7| 7| 3| 0| 7| 3| 9| 3| 2| 6| 7| 5| 7| 7| 3| 3| 7| 8| 1| 8| 6| 7|
| 1| 1| 2| 0| 5| 2| 7| 3| 7| 8| 1| 4| 5| 0| 5| 5| 5| 1| 1| 5| 7| 0| 9| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
D 61 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis | 2 |
Infiltration Cellular, Histiocyte | 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 2 2 2 2 3 2 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M + M + + M + M + + + + M + M + |
Galactocele | X |
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + |
Acanthosis | |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + |
Fibrosis | 2 |
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + |
Fungus | 2 |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Inflammation, Acute | 1 |
__________________________________________________________________________|
Eye | + + |
Hemorrhage | |
Lens, Cataract | 2 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 1| 7| 7| 6| 6| 5| 7| 7| 6| 4| 6| 1| 1| 7| 7| 1| 5| 7| 6| 6| 4|
DAY ON TEST | 3| 3| 3| 7| 7| 3| 0| 7| 3| 9| 3| 2| 6| 7| 5| 7| 7| 3| 3| 7| 8| 1| 8| 6| 7|
| 1| 1| 2| 0| 5| 2| 7| 3| 7| 8| 1| 4| 5| 0| 5| 5| 5| 1| 1| 5| 7| 0| 9| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
D 61 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + |
Cyst | X |
Nephropathy | 3 3 3 4 2 2 3 3 3 2 2 2 2 3 3 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + M + + + + + + + |
Calculus Micro Observation Only | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 7| 1| 6| 1| 6| 4| 6| 6| 2| 7| 7| 7| 4| 7| 4| 7| 6| 1| 6| 7| 4| 4| 4| 1|
DAY ON TEST | 3| 2| 7| 1| 7| 5| 7| 3| 2| 8| 3| 3| 3| 7| 2| 7| 1| 5| 7| 1| 1| 7| 7| 7| 7|
| 1| 5| 5| 0| 6| 8| 0| 7| 5| 8| 1| 2| 2| 0| 1| 0| 0| 1| 6| 9| 3| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
D 61 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A |
Parasite | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + |
Diverticulum | 3 |
Parasite | 2 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A |
Parasite | |
Thrombosis | 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Intestine Small, Ileum | + + + M + + + + + + + + + + A |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + M + + + + + + + + + + A |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + |
Angiectasis, Focal | |
Angiectasis | 2 |
Basophilic Focus | 1 X X X |
Clear Cell Focus | X X |
Cyst | |
Degeneration, Cystic | 2 |
Eosinophilic Focus | X |
Fatty Change, Diffuse | |
Fatty Change, Focal | 2 2 2 |
Hepatodiaphragmatic Nodule | X X X |
Mixed Cell Focus | X |
Necrosis | |
Thrombosis | |
Bile Duct, Hyperplasia | 2 2 1 2 1 2 2 3 2 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + |
Acinus, Atrophy | 1 2 2 1 1 2 |
Acinus, Basophilic Focus | |
Acinus, Hyperplasia | |
Duct, Hyperplasia | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + M + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + |
Acanthosis | 2 |
Hyperkeratosis | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + |
Mineralization | 1 2 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 7| 1| 6| 1| 6| 4| 6| 6| 2| 7| 7| 7| 4| 7| 4| 7| 6| 1| 6| 7| 4| 4| 4| 1|
DAY ON TEST | 3| 2| 7| 1| 7| 5| 7| 3| 2| 8| 3| 3| 3| 7| 2| 7| 1| 5| 7| 1| 1| 7| 7| 7| 7|
| 1| 5| 5| 0| 6| 8| 0| 7| 5| 8| 1| 2| 2| 0| 1| 0| 0| 1| 6| 9| 3| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
D 61 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Necrosis | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 2 2 2 2 1 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + |
Hyperplasia | 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + M M + + M + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + |
Pars Distalis, Angiectasis | 3 2 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 3 2 2 1 2 |
__________________________________________________________________________|
Prostate | + + + + + M + + + + + + + + + |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + M + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + |
Interstitial Cell, Hyperplasia | 1 2 1 1 1 1 |
Seminiferous Tubule, Atrophy | 2 3 4 3 2 4 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 7| 1| 6| 1| 6| 4| 6| 6| 2| 7| 7| 7| 4| 7| 4| 7| 6| 1| 6| 7| 4| 4| 4| 1|
DAY ON TEST | 3| 2| 7| 1| 7| 5| 7| 3| 2| 8| 3| 3| 3| 7| 2| 7| 1| 5| 7| 1| 1| 7| 7| 7| 7|
| 1| 5| 5| 0| 6| 8| 0| 7| 5| 8| 1| 2| 2| 0| 1| 0| 0| 1| 6| 9| 3| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
D 61 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis | |
Infiltration Cellular, Histiocyte | 2 2 1 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + |
Fibrosis | |
Hematopoietic Cell Proliferation | 3 2 |
__________________________________________________________________________|
Thymus | + + + M M M + + + + + + + + + |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + M M + M + M M |
Galactocele | X |
Acinus, Hyperplasia | 2 2 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + M |
Acanthosis | |
Cyst Epithelial Inclusion | |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + |
Fibrosis | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Nose | + + + + M + + + + + + + + + + |
Fungus | 2 |
Inflammation, Acute | 3 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
Inflammation, Acute | |
__________________________________________________________________________|
Eye | + + |
Hemorrhage | 2 |
Lens, Cataract | 2 |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 7| 1| 6| 1| 6| 4| 6| 6| 2| 7| 7| 7| 4| 7| 4| 7| 6| 1| 6| 7| 4| 4| 4| 1|
DAY ON TEST | 3| 2| 7| 1| 7| 5| 7| 3| 2| 8| 3| 3| 3| 7| 2| 7| 1| 5| 7| 1| 1| 7| 7| 7| 7|
| 1| 5| 5| 0| 6| 8| 0| 7| 5| 8| 1| 2| 2| 0| 1| 0| 0| 1| 6| 9| 3| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
D 61 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + |
Cyst | |
Nephropathy | 3 3 3 2 3 2 1 3 3 3 2 3 2 2 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + |
Calculus Micro Observation Only | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 1| 4| 7| 6| 5| | |
DAY ON TEST | 3| 3| 3| 6| 8| 3| 3| 9| 0| 7| 3| 3| 3| 3| 3| 7| 7| 2| 3| 0| | |
| 1| 1| 2| 6| 5| 1| 2| 4| 5| 6| 1| 1| 1| 2| 2| 5| 0| 2| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
D 61 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + M + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + | 47 |
Parasite | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + | 48 |
Diverticulum | | 1 3.0|
Parasite | 2 | 4 1.8|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + | 47 |
Parasite | | 1 2.0|
Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + M + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + | 50 |
Angiectasis, Focal | 3 | 1 3.0|
Angiectasis | 2 1 | 4 1.5|
Basophilic Focus | X X X X X X X X | 17 1.0|
Clear Cell Focus | X X | 6 |
Cyst | | 1 |
Degeneration, Cystic | | 2 1.5|
Eosinophilic Focus | X X X | 5 |
Fatty Change, Diffuse | 3 3 | 3 2.7|
Fatty Change, Focal | 2 | 9 2.0|
Hepatodiaphragmatic Nodule | X | 7 |
Mixed Cell Focus | | 1 |
Necrosis | | 1 3.0|
Thrombosis | | 3 2.0|
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 3 2 1 1 | 34 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + | 50 |
Acinus, Atrophy | 2 1 1 2 1 | 22 1.7|
Acinus, Basophilic Focus | X X X | 5 |
Acinus, Hyperplasia | | 1 2.0|
Duct, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 1| 4| 7| 6| 5| | |
DAY ON TEST | 3| 3| 3| 6| 8| 3| 3| 9| 0| 7| 3| 3| 3| 3| 3| 7| 7| 2| 3| 0| | |
| 1| 1| 2| 6| 5| 1| 2| 4| 5| 6| 1| 1| 1| 2| 2| 5| 0| 2| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
D 61 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + | 50 |
Acanthosis | 2 | 2 2.0|
Hyperkeratosis | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + | 49 |
Mineralization | 1 | 3 1.3|
Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + | 50 |
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 1 | 33 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + | 50 |
Hyperplasia | 2 2 1 2 2 | 12 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + M + + + + + + | 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + | 47 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | M + + + M + + + + + + + + + M + M | 45 |
Pars Distalis, Angiectasis | 2 3 | 8 2.3|
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | 2 2 2 2 2 | 8 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + | 49 |
C-Cell, Hyperplasia | | 4 1.8|
Follicle, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + M + + | 48 |
Inflammation, Chronic Active | 1 1 3 | 11 1.9|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + | 48 |
Epithelium, Hyperplasia | 2 3 | 4 2.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 1| 4| 7| 6| 5| | |
DAY ON TEST | 3| 3| 3| 6| 8| 3| 3| 9| 0| 7| 3| 3| 3| 3| 3| 7| 7| 2| 3| 0| | |
| 1| 1| 2| 6| 5| 1| 2| 4| 5| 6| 1| 1| 1| 2| 2| 5| 0| 2| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
D 61 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Hyperplasia | 1 2 1 1 1 1 2 1 | 20 1.4|
Seminiferous Tubule, Atrophy | 2 2 2 2 2 2 3 2 2 2 2 2 2 | 34 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + | 50 |
Renal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + | 46 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + | 49 |
Fibrosis | | 1 2.0|
Infiltration Cellular, Histiocyte | 2 2 2 | 10 1.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 50 |
Fibrosis | 2 3 2 | 4 2.5|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 3 4 | 20 2.4|
__________________________________________________________________________|____________|
Thymus | + M M + M + M + + + + M M + + + + | 41 |
Epithelial Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M + + M M + + + M + M M + M M | 28 |
Galactocele | | 2 |
Acinus, Hyperplasia | 2 1 | 7 1.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + M | 48 |
Acanthosis | 2 | 1 2.0|
Cyst Epithelial Inclusion | X | 2 |
Hyperkeratosis | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + | 50 |
Hemorrhage | 4 | 2 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + | 50 |
Fibrosis | | 2 2.0|
Infiltration Cellular, Histiocyte | 1 | 6 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 1| 4| 7| 6| 5| | |
DAY ON TEST | 3| 3| 3| 6| 8| 3| 3| 9| 0| 7| 3| 3| 3| 3| 3| 7| 7| 2| 3| 0| | |
| 1| 1| 2| 6| 5| 1| 2| 4| 5| 6| 1| 1| 1| 2| 2| 5| 0| 2| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
D 61 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Acute | | 2 2.5|
__________________________________________________________________________|____________|
Nose | M + + + + + + + + + + + + + + + M | 47 |
Fungus | | 2 2.0|
Inflammation, Acute | | 4 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + + | 6 |
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Eye | + + | 6 |
Hemorrhage | | 1 2.0|
Lens, Cataract | 3 2 | 4 2.3|
Retina, Atrophy | 3 | 2 3.5|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + | 50 |
Cyst | X X | 3 |
Nephropathy | 2 3 3 2 2 2 2 3 2 1 3 3 3 3 4 3 2 | 49 2.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + M + + + + + + + + + + + + | 48 |
Calculus Micro Observation Only | 2 X | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 1| 1| 7| 6| 6| 7| 7| 4| 1| 6| 7| 7| 6| 1| 3| 7| 7| 6| 5| 4| 1| 7| 6| 6| 6|
DAY ON TEST | 7| 7| 3| 2| 1| 3| 1| 7| 7| 7| 3| 3| 2| 7| 9| 2| 3| 2| 8| 8| 7| 3| 5| 4| 2|
| 6| 6| 0| 0| 9| 0| 8| 0| 6| 2| 0| 0| 6| 6| 6| 8| 0| 6| 8| 1| 5| 0| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
61LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + M + + + M + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X |
Clear Cell Focus | X X |
Degeneration, Cystic | 2 |
Eosinophilic Focus | |
Fatty Change, Focal | 2 3 1 3|
Hepatodiaphragmatic Nodule | X X |
Hyperplasia, Focal | |
Mixed Cell Focus | X |
Necrosis | 1 3 2 |
Thrombosis | 4 |
Bile Duct, Hyperplasia | 1 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + A|
Acinus, Atrophy | 2 2 2 2 1 1 2 2 2 |
Acinus, Basophilic Focus | |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 2 |
Hyperkeratosis | |
Necrosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 3 2 2 2 2 2 2 1 2 2 1 2 3 3|
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 1| 1| 7| 6| 6| 7| 7| 4| 1| 6| 7| 7| 6| 1| 3| 7| 7| 6| 5| 4| 1| 7| 6| 6| 6|
DAY ON TEST | 7| 7| 3| 2| 1| 3| 1| 7| 7| 7| 3| 3| 2| 7| 9| 2| 3| 2| 8| 8| 7| 3| 5| 4| 2|
| 6| 6| 0| 0| 9| 0| 8| 0| 6| 2| 0| 0| 6| 6| 6| 8| 0| 6| 8| 1| 5| 0| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
61LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + M + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + M + M + + + M|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 2 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 3 2 1 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + M + + + + + + + + + + +|
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 1 1 2 1 1 1 1 1 2 1 2 |
Seminiferous Tubule, Atrophy | 2 3 3 2 2 2 2 4 3 3 3 2 2 2 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | 2 3 2 3 2 3 |
__________________________________________________________________________|
Thymus | + + + M + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M M M M M + + + M M + + M M M +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 1| 1| 7| 6| 6| 7| 7| 4| 1| 6| 7| 7| 6| 1| 3| 7| 7| 6| 5| 4| 1| 7| 6| 6| 6|
DAY ON TEST | 7| 7| 3| 2| 1| 3| 1| 7| 7| 7| 3| 3| 2| 7| 9| 2| 3| 2| 8| 8| 7| 3| 5| 4| 2|
| 6| 6| 0| 0| 9| 0| 8| 0| 6| 2| 0| 0| 6| 6| 6| 8| 0| 6| 8| 1| 5| 0| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
61LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Galactocele | |
Acinus, Hyperplasia | 1 3 2 2 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 2 |
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 2 3 2 3 2 2 2 2 2 2 2 2 2 1 3 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + M + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 1| 7| 6| 1| 7| 1| 7| 4| 1| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 2| 6| 3| 7| 3| 5| 7| 3| 7| 3| 6| 7| 7| 3| 7| 7| 3| 7| 3| 3| 3| 2|
| 0| 0| 0| 8| 8| 0| 6| 0| 3| 6| 0| 5| 0| 7| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
61LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + M +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + M +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X |
Clear Cell Focus | X |
Degeneration, Cystic | 1 |
Eosinophilic Focus | X X |
Fatty Change, Focal | 1 1 2 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Focal | 2 |
Mixed Cell Focus | X X |
Necrosis | |
Thrombosis | |
Bile Duct, Hyperplasia | 2 2 2 3 2 2 1 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + M + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 1 1 2 2 |
Acinus, Basophilic Focus | X |
Acinus, Hyperplasia | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | 2 |
Necrosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + +|
Hyperplasia | |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 3 2 2 2 2 3 2 2 2 2|
Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 1| 7| 6| 1| 7| 1| 7| 4| 1| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 2| 6| 3| 7| 3| 5| 7| 3| 7| 3| 6| 7| 7| 3| 7| 7| 3| 7| 3| 3| 3| 2|
| 0| 0| 0| 8| 8| 0| 6| 0| 3| 6| 0| 5| 0| 7| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
61LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + M + + + + + + + + + + + +|
Hyperplasia | 2 2 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + M + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + A + + + + + +|
C-Cell, Hyperplasia | 2 1 1 2 1 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 1 1 1 1 2 |
Seminiferous Tubule, Atrophy | 2 2 3 2 3 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + +|
Renal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + +|
Cyst | |
Fibrosis | |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M M + + + M M M M M +|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 1| 7| 6| 1| 7| 1| 7| 4| 1| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 2| 6| 3| 7| 3| 5| 7| 3| 7| 3| 6| 7| 7| 3| 7| 7| 3| 7| 3| 3| 3| 2|
| 0| 0| 0| 8| 8| 0| 6| 0| 3| 6| 0| 5| 0| 7| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
61LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Galactocele | X |
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Acute | 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 2 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 2 2 3 3 2 3 2 3 3 2 3 3 2 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 1| 7| 7| 7| 4| 7| 6| 7| 7| 3| | |
DAY ON TEST | 3| 3| 3| 7| 7| 3| 3| 3| 2| 7| 7| 3| 3| 3| 7| 3| 7| 3| 3| 6| | |
| 0| 0| 0| 0| 0| 1| 0| 0| 3| 0| 6| 1| 1| 1| 0| 1| 3| 1| 1| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
61LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + M + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + M + + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 50 |
Angiectasis | | 1 2.0|
Basophilic Focus | X X X X X X X | 21 |
Clear Cell Focus | X X | 5 |
Degeneration, Cystic | 2 | 3 1.7|
Eosinophilic Focus | | 2 |
Fatty Change, Focal | 1 | 8 1.8|
Hepatodiaphragmatic Nodule | X | 4 |
Hyperplasia, Focal | | 1 2.0|
Mixed Cell Focus | | 3 |
Necrosis | | 3 2.0|
Thrombosis | | 1 4.0|
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 | 36 2.0|
__________________________________________________________________________|____________|
Mesentery | | 5 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 48 |
Acinus, Atrophy | 2 2 2 2 3 2 | 21 1.9|
Acinus, Basophilic Focus | | 1 |
Acinus, Hyperplasia | 2 2 | 3 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + M + | 48 |
Acanthosis | | 2 1.5|
Hyperkeratosis | | 1 2.0|
Necrosis | 3 4 | 3 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 48 |
Hyperplasia | 1 | 1 1.0|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 1| 7| 7| 7| 4| 7| 6| 7| 7| 3| | |
DAY ON TEST | 3| 3| 3| 7| 7| 3| 3| 3| 2| 7| 7| 3| 3| 3| 7| 3| 7| 3| 3| 6| | |
| 0| 0| 0| 0| 0| 1| 0| 0| 3| 0| 6| 1| 1| 1| 0| 1| 3| 1| 1| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
61LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 1 | 42 2.0|
Thrombosis | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + | 49 |
Hyperplasia | 1 2 2 1 2 2 2 | 16 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + M + + | 47 |
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + | 44 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + M | 49 |
Pars Distalis, Angiectasis | 2 2 3 3 | 11 2.5|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 2 2 | 13 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 49 |
C-Cell, Hyperplasia | 1 | 9 1.2|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + | 50 |
Inflammation, Chronic Active | 4 | 6 2.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + | 49 |
Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 50 |
Interstitial Cell, Hyperplasia | 2 1 2 1 1 2 2 2 | 27 1.4|
Seminiferous Tubule, Atrophy | 2 2 2 2 2 2 2 3 2 | 31 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + | 50 |
Renal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + | 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 1| 7| 7| 7| 4| 7| 6| 7| 7| 3| | |
DAY ON TEST | 3| 3| 3| 7| 7| 3| 3| 3| 2| 7| 7| 3| 3| 3| 7| 3| 7| 3| 3| 6| | |
| 0| 0| 0| 0| 0| 1| 0| 0| 3| 0| 6| 1| 1| 1| 0| 1| 3| 1| 1| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
61LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 50 |
Infiltration Cellular, Histiocyte | | 3 1.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 50 |
Cyst | | 1 2.0|
Fibrosis | | 2 2.0|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 | 12 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M M + M + + + M | 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M + M M M + + M + + M | 18 |
Galactocele | X | 2 |
Acinus, Hyperplasia | | 6 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 50 |
Hyperkeratosis | | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 50 |
Hemorrhage | | 2 2.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 50 |
Infiltration Cellular, Histiocyte | 1 2 | 6 1.3|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 50 |
Fungus | 2 | 1 2.0|
Inflammation, Acute | 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + | 4 |
__________________________________________________________________________|____________|
Eye | + + + | 6 |
Lens, Cataract | 2 2 3 | 4 2.3|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 1| 7| 7| 7| 4| 7| 6| 7| 7| 3| | |
DAY ON TEST | 3| 3| 3| 7| 7| 3| 3| 3| 2| 7| 7| 3| 3| 3| 7| 3| 7| 3| 3| 6| | |
| 0| 0| 0| 0| 0| 1| 0| 0| 3| 0| 6| 1| 1| 1| 0| 1| 3| 1| 1| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
61LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 50 |
Cyst | X X | 2 |
Nephropathy | 3 2 2 3 2 3 2 3 2 3 3 3 3 2 2 | 49 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 1| 7| 1| 6| 7| 7| 6| 6| 4| 0| 7| 7| 7| 1| 7| 7| 4| 6| 1|
DAY ON TEST | 2| 7| 2| 2| 2| 2| 7| 2| 7| 6| 2| 2| 9| 5| 7| 5| 2| 2| 0| 7| 2| 2| 7| 7| 7|
| 9| 0| 9| 9| 9| 9| 5| 9| 6| 8| 9| 9| 4| 4| 0| 2| 9| 9| 4| 5| 9| 9| 0| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
61HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + A + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + A + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + M M + + + M + + |
Parasite | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + A + + + + + + |
Parasite | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + A + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + A + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + |
Angiectasis, Focal | 3 |
Angiectasis | 1 2 |
Basophilic Focus | X X X X X X |
Clear Cell Focus | X X X |
Degeneration, Cystic | 1 2 |
Eosinophilic Focus | X X X |
Fatty Change, Diffuse | 2 |
Fatty Change, Focal | 2 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Focal | 2 |
Mixed Cell Focus | X |
Necrosis | 2 |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 3 3 2 2 2 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + M + + + + + + |
Acinus, Atrophy | 2 2 2 3 2 |
Acinus, Basophilic Focus | X |
Acinus, Hyperplasia | 2 1 |
Artery, Fibrosis | 2 |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + A + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + |
Hyperkeratosis | 3 |
Necrosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + |
Mineralization | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 1| 7| 1| 6| 7| 7| 6| 6| 4| 0| 7| 7| 7| 1| 7| 7| 4| 6| 1|
DAY ON TEST | 2| 7| 2| 2| 2| 2| 7| 2| 7| 6| 2| 2| 9| 5| 7| 5| 2| 2| 0| 7| 2| 2| 7| 7| 7|
| 9| 0| 9| 9| 9| 9| 5| 9| 6| 8| 9| 9| 4| 4| 0| 2| 9| 9| 4| 5| 9| 9| 0| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
61HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 3 2 2 2 2 2 2 2 2 2 2 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 2 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + M + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + M + + |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | 2 2 4 2 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 2 2 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + A + + + + + + + + + + |
C-Cell, Hyperplasia | 2 2 2 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + |
Granuloma Sperm | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + M + + + + M + + |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + |
Interstitial Cell, Hyperplasia | 2 2 1 2 1 1 2 1 2 2 2 |
Seminiferous Tubule, Atrophy | 3 2 2 3 2 2 3 3 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + A + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + |
Mediastinal, Fibrosis | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + M + + + + + + + + + + + + + |
Infiltration Cellular, Histiocyte | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 1| 7| 1| 6| 7| 7| 6| 6| 4| 0| 7| 7| 7| 1| 7| 7| 4| 6| 1|
DAY ON TEST | 2| 7| 2| 2| 2| 2| 7| 2| 7| 6| 2| 2| 9| 5| 7| 5| 2| 2| 0| 7| 2| 2| 7| 7| 7|
| 9| 0| 9| 9| 9| 9| 5| 9| 6| 8| 9| 9| 4| 4| 0| 2| 9| 9| 4| 5| 9| 9| 0| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
61HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + |
Fibrosis | 2 2 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + M M M + + M + + + M M + |
Galactocele | X |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + |
Acanthosis | |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + |
Hemorrhage | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + |
Fibrosis | 2 |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Acute | 1 |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + |
Fungus | |
Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + |
Lens, Cataract | 2 3 2 |
Retina, Atrophy | 2 3 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 1| 7| 1| 6| 7| 7| 6| 6| 4| 0| 7| 7| 7| 1| 7| 7| 4| 6| 1|
DAY ON TEST | 2| 7| 2| 2| 2| 2| 7| 2| 7| 6| 2| 2| 9| 5| 7| 5| 2| 2| 0| 7| 2| 2| 7| 7| 7|
| 9| 0| 9| 9| 9| 9| 5| 9| 6| 8| 9| 9| 4| 4| 0| 2| 9| 9| 4| 5| 9| 9| 0| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
61HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cyst | X |
Hydronephrosis | |
Nephropathy | 3 3 2 2 3 4 2 3 2 2 3 2 2 3 3 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + M + + |
Calculus Gross Observation | |
Calculus Micro Observation Only | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 1| 6| 1| 1| 1| 7| 7| 7| 7| 1| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3|
DAY ON TEST | 1| 7| 9| 7| 7| 7| 2| 2| 2| 2| 7| 7| 2| 1| 8| 2| 2| 2| 2| 2| 3| 0| 9| 5| 6|
| 4| 5| 4| 6| 5| 6| 9| 9| 9| 9| 6| 0| 9| 5| 8| 9| 9| 9| 9| 9| 0| 2| 4| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
61HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
Parasite | 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
Parasite | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Angiectasis | 2 |
Basophilic Focus | X X X X X X |
Clear Cell Focus | X X X X |
Degeneration, Cystic | |
Eosinophilic Focus | X |
Fatty Change, Diffuse | |
Fatty Change, Focal | |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Focal | |
Mixed Cell Focus | |
Necrosis | 1 3 |
Bile Duct, Hyperplasia | 2 2 3 2 2 2 2 2 2 2 2 2 3 3 2 1|
__________________________________________________________________________|
Mesentery | M |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 2 2 2 2 2 1 1 1 1 1 1 |
Acinus, Basophilic Focus | X X |
Acinus, Hyperplasia | 2 2 |
Artery, Fibrosis | 2 |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Necrosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 1| 6| 1| 1| 1| 7| 7| 7| 7| 1| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3|
DAY ON TEST | 1| 7| 9| 7| 7| 7| 2| 2| 2| 2| 7| 7| 2| 1| 8| 2| 2| 2| 2| 2| 3| 0| 9| 5| 6|
| 4| 5| 4| 6| 5| 6| 9| 9| 9| 9| 6| 0| 9| 5| 8| 9| 9| 9| 9| 9| 0| 2| 4| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
61HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 1|
Thrombosis | 2 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + M + + + + M M + + + + + M + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 3 4|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 2 2 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + M +|
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 1 1 2 1 2 2 2 2 2 |
Seminiferous Tubule, Atrophy | 2 2 2 3 2 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Mediastinal, Fibrosis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 1| 6| 1| 1| 1| 7| 7| 7| 7| 1| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3|
DAY ON TEST | 1| 7| 9| 7| 7| 7| 2| 2| 2| 2| 7| 7| 2| 1| 8| 2| 2| 2| 2| 2| 3| 0| 9| 5| 6|
| 4| 5| 4| 6| 5| 6| 9| 9| 9| 9| 6| 0| 9| 5| 8| 9| 9| 9| 9| 9| 0| 2| 4| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
61HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + M M M M M + M + + M + + + + +|
Galactocele | X |
Acinus, Hyperplasia | 2|
__________________________________________________________________________|
Skin | M + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Acute | |
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Fungus | 2 |
Inflammation, Acute | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + +|
Lens, Cataract | 2 2 |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
_____________________________________________________________________________________________________________________
| 7| 1| 6| 1| 1| 1| 7| 7| 7| 7| 1| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3|
DAY ON TEST | 1| 7| 9| 7| 7| 7| 2| 2| 2| 2| 7| 7| 2| 1| 8| 2| 2| 2| 2| 2| 3| 0| 9| 5| 6|
| 4| 5| 4| 6| 5| 6| 9| 9| 9| 9| 6| 0| 9| 5| 8| 9| 9| 9| 9| 9| 0| 2| 4| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
61HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cyst | X X |
Hydronephrosis | 2 |
Nephropathy | 3 3 2 2 2 2 3 2 2 2 2 3 2 3 3 2 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | X |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
__________________________________________________________________________________________________________________________________
| 7| 5| 4| 4| 4| 7| 4| 7| 6| 4| 7| 6| 5| 5| 4| 7| 4| 4| 1| 6| | |
DAY ON TEST | 3| 5| 7| 3| 3| 3| 7| 2| 0| 7| 3| 9| 7| 5| 7| 3| 7| 7| 7| 8| | |
| 0| 3| 0| 6| 0| 0| 0| 9| 5| 0| 0| 6| 0| 7| 0| 0| 0| 0| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
61HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + A + + | 45 |
Parasite | 1 2 1 | 5 1.6|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + | 47 |
Parasite | 1 | 2 1.5|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + A + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + A + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A + + | 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + | 49 |
Angiectasis, Focal | | 1 3.0|
Angiectasis | 2 | 4 1.8|
Basophilic Focus | X X X X | 16 |
Clear Cell Focus | X X X | 10 |
Degeneration, Cystic | 1 1 | 4 1.3|
Eosinophilic Focus | X X | 6 |
Fatty Change, Diffuse | | 1 2.0|
Fatty Change, Focal | 3 1 | 3 2.0|
Hepatodiaphragmatic Nodule | X | 5 |
Hyperplasia, Focal | | 1 2.0|
Mixed Cell Focus | | 1 |
Necrosis | | 3 2.0|
Bile Duct, Hyperplasia | 2 2 1 2 2 2 2 2 2 2 2 3 | 41 2.1|
__________________________________________________________________________|____________|
Mesentery | M + | 1 |
Fat, Inflammation, Chronic Active | 3 | 1 3.0|
Fat, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + | 48 |
Acinus, Atrophy | 2 2 2 2 3 | 23 1.8|
Acinus, Basophilic Focus | | 3 |
Acinus, Hyperplasia | 2 | 5 1.8|
Artery, Fibrosis | 2 3 | 4 2.3|
Artery, Inflammation, Chronic Active | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + | 49 |
Hyperkeratosis | | 1 3.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
__________________________________________________________________________________________________________________________________
| 7| 5| 4| 4| 4| 7| 4| 7| 6| 4| 7| 6| 5| 5| 4| 7| 4| 4| 1| 6| | |
DAY ON TEST | 3| 5| 7| 3| 3| 3| 7| 2| 0| 7| 3| 9| 7| 5| 7| 3| 7| 7| 7| 8| | |
| 0| 3| 0| 6| 0| 0| 0| 9| 5| 0| 0| 6| 0| 7| 0| 0| 0| 0| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
61HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + A + + | 48 |
Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tongue | + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + | 49 |
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 | 34 2.0|
Thrombosis | | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + M + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + M + + + + + + + + + | 48 |
Hyperplasia | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + M + + + + + + + + + | 48 |
Hyperplasia | 2 2 2 1 3 | 14 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M M + M + + M + + | 37 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + | 49 |
Pars Distalis, Angiectasis | | 10 2.6|
Pars Distalis, Cyst | 1 X | 3 1.0|
Pars Distalis, Hyperplasia | 2 3 2 2 3 2 2 2 | 18 2.1|
Pars Intermedia, Cyst | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + | 48 |
C-Cell, Hyperplasia | 1 | 6 1.5|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + | 49 |
Granuloma Sperm | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + | 49 |
Inflammation, Chronic Active | 1 1 | 5 1.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + | 46 |
Epithelium, Hyperplasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
__________________________________________________________________________________________________________________________________
| 7| 5| 4| 4| 4| 7| 4| 7| 6| 4| 7| 6| 5| 5| 4| 7| 4| 4| 1| 6| | |
DAY ON TEST | 3| 5| 7| 3| 3| 3| 7| 2| 0| 7| 3| 9| 7| 5| 7| 3| 7| 7| 7| 8| | |
| 0| 3| 0| 6| 0| 0| 0| 9| 5| 0| 0| 6| 0| 7| 0| 0| 0| 0| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
61HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Hyperplasia | 1 2 1 2 1 2 2 2 | 29 1.7|
Seminiferous Tubule, Atrophy | 2 3 2 3 | 21 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + | 49 |
Mediastinal, Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + | 47 |
Infiltration Cellular, Histiocyte | 2 1 2 2 1 1 | 7 1.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + A + + | 48 |
Fibrosis | 2 | 5 2.0|
Hematopoietic Cell Proliferation | 2 4 2 2 2 3 2 | 25 2.1|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + + | 47 |
Cyst | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + M M M M + M + + + | 26 |
Galactocele | | 2 |
Acinus, Hyperplasia | 1 2 1 2 | 5 1.6|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + M + | 47 |
Acanthosis | 2 | 1 2.0|
Cyst Epithelial Inclusion | X | 3 |
Hyperkeratosis | 4 4 | 4 3.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + | 49 |
Hemorrhage | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + | 49 |
Fibrosis | 2 | 2 2.0|
Infiltration Cellular, Histiocyte | 1 2 1 | 5 1.4|
Inflammation, Acute | | 1 1.0|
Metaplasia, Osseous | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05057-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HC YELLOW 4 Date: 04/25/97
Route: DOSED FEED Time: 16:37:44
__________________________________________________________________________________________________________________________________
| 7| 5| 4| 4| 4| 7| 4| 7| 6| 4| 7| 6| 5| 5| 4| 7| 4| 4| 1| 6| | |
DAY ON TEST | 3| 5| 7| 3| 3| 3| 7| 2| 0| 7| 3| 9| 7| 5| 7| 3| 7| 7| 7| 8| | |
| 0| 3| 0| 6| 0| 0| 0| 9| 5| 0| 0| 6| 0| 7| 0| 0| 0| 0| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
61HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + | 49 |
Fungus | | 1 2.0|
Inflammation, Acute | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | + + + + + | 12 |
Lens, Cataract | 2 | 6 2.2|
Retina, Atrophy | 2 | 3 2.3|
__________________________________________________________________________|____________|
Harderian Gland | + + + + | 6 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + | 49 |
Cyst | X | 4 |
Hydronephrosis | 4 | 2 3.0|
Nephropathy | 3 2 1 3 3 3 3 1 2 1 3 2 | 47 2.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + A + + | 47 |
Calculus Gross Observation | | 1 |
Calculus Micro Observation Only | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
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---------- END OF REPORT ----------
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