TDMS Study 05058-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
ROXARSONE
NTP Experiment-Test: 05058-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/12/94
Route: DOSED FEED Time: 08:58:55
Facility: Southern Research Institute
Chemical CAS #: 121-19-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05058-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ROXARSONE Date: 09/12/94
Route: DOSED FEED Time: 08:58:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.01% 0.02%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Natural Death 14 15 12
Moribund Sacrifice 21 17 21
Accidently Killed 1
Survivors
Terminal Sacrifice 14 18 17
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (45) (45) (47)
Epithelium, Degeneration, Hyaline 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Serosa, Inflammation, Suppurative 1 (2%)
Intestine Large, Cecum (48) (49) (46)
Edema 1 (2%)
Intestine Small, Duodenum (47) (50) (46)
Ulcer 1 (2%)
Intestine Small, Jejunum (49) (50) (46)
Hyperplasia, Lymphoid 1 (2%)
Perforation 1 (2%)
Liver (50) (50) (50)
Congestion 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 10 (20%) 20 (40%) 18 (36%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Infarct 1 (2%) 1 (2%)
Infiltration Cellular, Polymorphonuclear 21 (42%) 24 (48%) 20 (40%)
Inflammation, Focal 1 (2%) 1 (2%)
Necrosis, Focal 3 (6%) 1 (2%)
Necrosis, Multifocal 1 (2%)
Vacuolization Cytoplasmic 1 (2%) 1 (2%)
Bile Duct, Degeneration, Hyaline 1 (2%)
Bile Duct, Hyperplasia 1 (2%)
Centrilobular, Vacuolization Cytoplasmic 1 (2%)
Serosa, Inflammation, Suppurative 3 (6%)
Mesentery (27) (27) (30)
Inflammation, Suppurative 23 (85%) 25 (93%) 29 (97%)
Fat, Necrosis 2 (7%) 1 (4%) 1 (3%)
Pancreas (50) (50) (49)
Atrophy, Focal 2 (4%)
Edema 1 (2%)
Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05058-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ROXARSONE Date: 09/12/94
Route: DOSED FEED Time: 08:58:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.01% 0.02%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Duct, Hyperplasia, Cystic 1 (2%)
Stomach, Forestomach (50) (50) (49)
Hyperplasia, Papillary 1 (2%) 6 (12%)
Inflammation, Diffuse, Suppurative 1 (2%)
Inflammation, Focal 3 (6%)
Ulcer 1 (2%)
Stomach, Glandular (50) (50) (49)
Hyperplasia, Lymphoid 1 (2%)
Necrosis, Focal 1 (2%)
Pigmentation 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Abdominal, Thrombosis 1 (100%)
Heart (50) (50) (50)
Inflammation, Suppurative 1 (2%) 2 (4%) 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Artery, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (49) (50)
Angiectasis 1 (2%)
Congestion 2 (4%) 1 (2%)
Hematopoietic Cell Proliferation 2 (4%)
Hyperplasia, Focal 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Inflammation, Suppurative 1 (2%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Capsule, Inflammation, Suppurative 1 (2%) 1 (2%)
Corticomedullary Junction, Degeneration,
Fatty 1 (2%)
Extra Adrenal Tissue, Inflammation,
Suppurative 4 (8%) 2 (4%)
Subcapsular, Hyperplasia, Focal 1 (2%)
Adrenal Gland, Medulla (50) (49) (50)
Angiectasis 1 (2%)
Developmental Malformation 1 (2%) 1 (2%)
Hyperplasia, Focal 1 (2%)
Parathyroid Gland (46) (44) (47)
Cyst 1 (2%) 1 (2%)
Pituitary Gland (49) (46) (49)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05058-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ROXARSONE Date: 09/12/94
Route: DOSED FEED Time: 08:58:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.01% 0.02%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Hyperplasia, Focal 7 (14%) 5 (11%) 1 (2%)
Thyroid Gland (49) (49) (49)
Cyst 1 (2%) 2 (4%)
Degeneration, Cystic 5 (10%) 2 (4%) 8 (16%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Bacterium 1 (100%)
Hyperplasia, Neutrophil 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (1)
Inflammation, Suppurative 1 (100%)
Ovary (49) (49) (50)
Angiectasis 1 (2%)
Granuloma 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 2 (4%)
Inflammation, Suppurative 25 (51%) 29 (59%) 29 (58%)
Follicle, Cyst 10 (20%) 18 (37%) 17 (34%)
Oviduct (7) (3) (3)
Dilatation 1 (14%)
Inflammation, Suppurative 6 (86%) 3 (100%) 3 (100%)
Uterus (50) (50) (50)
Angiectasis 1 (2%)
Hydrometra 1 (2%) 1 (2%)
Inflammation, Suppurative 21 (42%) 33 (66%) 23 (46%)
Thrombosis 1 (2%)
Endometrium, Hyperplasia, Cystic 46 (92%) 49 (98%) 48 (96%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Angiectasis 3 (6%) 1 (2%)
Myelofibrosis 1 (2%)
Lymph Node (50) (50) (50)
Bronchial, Bacterium 1 (2%)
Bronchial, Hyperplasia 1 (2%) 3 (6%)
Bronchial, Inflammation, Suppurative 1 (2%) 3 (6%)
Bronchial, Mediastinal, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05058-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ROXARSONE Date: 09/12/94
Route: DOSED FEED Time: 08:58:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.01% 0.02%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Iliac, Hyperplasia 1 (2%) 4 (8%) 8 (16%)
Iliac, Hyperplasia, Lymphoid 1 (2%)
Iliac, Inflammation, Suppurative 1 (2%)
Inguinal, Hyperplasia 1 (2%)
Inguinal, Hyperplasia, Lymphoid 1 (2%)
Lumbar, Hyperplasia 1 (2%) 3 (6%)
Mediastinal, Cyst 1 (2%)
Mediastinal, Hyperplasia 6 (12%) 7 (14%) 7 (14%)
Mediastinal, Inflammation, Suppurative 4 (8%) 5 (10%)
Pancreatic, Hyperplasia 1 (2%)
Pancreatic, Hyperplasia, Lymphoid 1 (2%)
Renal, Angiectasis 1 (2%)
Renal, Hyperplasia 13 (26%) 14 (28%) 16 (32%)
Renal, Hyperplasia, Lymphoid 1 (2%)
Renal, Inflammation, Suppurative 1 (2%) 1 (2%)
Renal, Mediastinal, Hyperplasia 1 (2%)
Lymph Node, Mandibular (40) (48) (42)
Hyperplasia 1 (3%) 3 (7%)
Hyperplasia, Lymphoid 3 (8%) 1 (2%)
Lymph Node, Mesenteric (48) (48) (46)
Angiectasis 5 (10%) 6 (13%) 10 (22%)
Hematopoietic Cell Proliferation 2 (4%)
Hyperplasia 3 (6%) 4 (8%) 3 (7%)
Hyperplasia, Lymphoid 2 (4%) 1 (2%)
Spleen (50) (50) (49)
Angiectasis 1 (2%)
Hematopoietic Cell Proliferation 29 (58%) 30 (60%) 31 (63%)
Hyperplasia, Lymphoid 2 (4%) 2 (4%)
Infarct 1 (2%)
Inflammation, Suppurative 1 (2%)
Red Pulp, Depletion Cellular 1 (2%)
Thymus (39) (42) (44)
Hyperplasia, Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50)
Duct, Dilatation 2 (4%) 7 (14%) 10 (20%)
Skin (50) (50) (50)
Inflammation, Chronic 2 (4%) 2 (4%) 3 (6%)
Inflammation, Suppurative 1 (2%)
Subcutaneous Tissue, Edema 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrosis 1 (2%)
Subcutaneous Tissue, Inflammation,
Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05058-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ROXARSONE Date: 09/12/94
Route: DOSED FEED Time: 08:58:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.01% 0.02%
CONTROL
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (6) (2) (2)
Inflammation, Suppurative 3 (50%) 2 (100%) 2 (100%)
Adventitia, Inflammation, Focal 1 (17%) 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (50)
Compression 1 (2%) 3 (6%)
Hemorrhage, Focal 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Mineralization 26 (52%) 25 (51%) 19 (38%)
Meninges, Inflammation, Chronic 1 (2%)
Ventricle, Mineralization, Focal 1 (2%)
Peripheral Nerve (50) (50) (50)
Sciatic, Hyperplasia, Lymphoid 1 (2%)
Spinal Cord (50) (50) (50)
Hemorrhage, Focal 1 (2%)
Necrosis, Focal 1 (2%)
Meninges, Hyperplasia, Lymphoid 4 (8%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Adenomatosis 19 (38%) 23 (46%) 13 (26%)
Congestion 6 (12%) 2 (4%) 2 (4%)
Hemorrhage, Focal 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 4 (8%) 4 (8%) 1 (2%)
Hyperplasia, Macrophage 1 (2%) 3 (6%) 2 (4%)
Infiltration Cellular, Polymorphonuclear 17 (34%) 14 (28%) 15 (30%)
Inflammation, Focal 18 (36%) 21 (42%) 12 (24%)
Inflammation, Suppurative 1 (2%) 4 (8%) 4 (8%)
Mineralization 2 (4%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 3 (6%) 4 (8%) 1 (2%)
Alveolar Epithelium, Metaplasia, Focal 2 (4%) 2 (4%) 1 (2%)
Mediastinum, Inflammation, Suppurative 8 (16%) 7 (14%) 7 (14%)
Nose (48) (50) (50)
Cyst 1 (2%)
Lumen, Exudate 4 (8%)
Lumen, Foreign Body 2 (4%)
Mucosa, Inflammation, Suppurative 2 (4%)
Nasolacrimal Duct, Inflammation 1 (2%)
Trachea (49) (50) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05058-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ROXARSONE Date: 09/12/94
Route: DOSED FEED Time: 08:58:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.01% 0.02%
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Glands, Dilatation 1 (2%)
Glands, Exudate 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (2) (3) (3)
Foreign Body 1 (33%)
Hyperplasia, Focal 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49)
Congestion 1 (2%)
Cyst 1 (2%)
Fibrosis 1 (2%)
Hyperplasia, Lymphoid 7 (14%) 1 (2%) 1 (2%)
Infarct 1 (2%)
Infiltration Cellular, Polymorphonuclear 6 (12%) 2 (4%) 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%) 4 (8%) 1 (2%)
Inflammation, Multifocal 2 (4%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
Metaplasia, Osseous 1 (2%)
Mineralization 1 (2%) 4 (8%) 1 (2%)
Nephropathy 7 (14%) 4 (8%) 3 (6%)
Pigmentation 1 (2%)
Capsule, Inflammation, Suppurative 3 (6%) 12 (24%) 5 (10%)
Glomerulus, Inflammation 3 (6%)
Papilla, Necrosis 1 (2%) 1 (2%)
Renal Tubule, Degeneration, Hyaline 1 (2%)
Renal Tubule, Vacuolization Cytoplasmic 1 (2%)
Urethra (1)
Inflammation, Suppurative 1 (100%)
Mineralization 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05058-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ROXARSONE Date: 09/12/94
Route: DOSED FEED Time: 08:58:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.01% 0.02%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund Sacrifice 17 9 11
Natural Death 6 1 6
Survivors
Terminal Sacrifice 27 40 33
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (42) (42) (48)
Hyperplasia, Papillary 1 (2%)
Intestine Large, Rectum (47) (49) (46)
Dysplasia 2 (4%)
Inflammation, Chronic 2 (4%)
Prolapse 2 (4%)
Ulcer 2 (4%)
Intestine Small, Duodenum (49) (45) (47)
Submucosa, Degeneration, Focal 1 (2%)
Intestine Small, Jejunum (49) (49) (48)
Lymphoid Tissue, Hyperplasia, Lymphoid 1 (2%)
Liver (50) (50) (50)
Angiectasis 1 (2%) 2 (4%)
Atrophy 1 (2%)
Basophilic Focus 1 (2%)
Cyst 1 (2%)
Cyst Multilocular 1 (2%)
Developmental Malformation 1 (2%)
Eosinophilic Focus 1 (2%)
Fibrosis, Focal 2 (4%) 2 (4%)
Focal Cellular Change 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Infarct 1 (2%) 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Inflammation, Focal 2 (4%)
Mineralization, Focal 1 (2%) 2 (4%)
Necrosis, Focal 2 (4%) 2 (4%) 1 (2%)
Necrosis, Multifocal 1 (2%) 1 (2%)
Nuclear Alteration 1 (2%)
Pigmentation 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Bile Duct, Dilatation 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05058-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ROXARSONE Date: 09/12/94
Route: DOSED FEED Time: 08:58:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.01% 0.02%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Bile Duct, Hyperplasia 2 (4%)
Centrilobular, Necrosis 1 (2%) 1 (2%)
Mesentery (4) (4) (6)
Hemorrhage 1 (25%)
Hyperplasia, Lymphoid 1 (25%)
Inflammation, Suppurative 1 (25%) 1 (17%)
Fat, Necrosis 2 (50%) 4 (67%)
Pancreas (49) (50) (50)
Accessory Spleen 1 (2%)
Atrophy, Focal 1 (2%)
Edema 1 (2%)
Stomach, Forestomach (50) (50) (50)
Hyperplasia, Papillary 1 (2%) 2 (4%)
Inflammation, Focal 1 (2%) 3 (6%)
Pigmentation, Focal 1 (2%)
Stomach, Glandular (50) (50) (50)
Degeneration, Hyaline 1 (2%)
Mineralization 1 (2%) 2 (4%) 2 (4%)
Tooth (14) (8) (7)
Incisor, Dysplasia 12 (86%) 8 (100%) 4 (57%)
Incisor, Inflammation, Suppurative 8 (57%) 2 (25%) 5 (71%)
Molar, Inflammation, Suppurative 1 (14%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1)
Abdominal, Inflammation, Chronic 1 (100%)
Mesenteric Artery, Inflammation, Chronic 1 (100%)
Heart (50) (50) (50)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Inflammation, Focal 1 (2%)
Mineralization 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (49)
Cyst 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Vacuolization Cytoplasmic, Focal 2 (4%)
Subcapsular, Hyperplasia, Focal 2 (4%) 1 (2%)
Adrenal Gland, Medulla (50) (50) (49)
Hyperplasia, Focal 1 (2%) 1 (2%) 2 (4%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Parathyroid Gland (47) (44) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05058-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ROXARSONE Date: 09/12/94
Route: DOSED FEED Time: 08:58:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.01% 0.02%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Cyst 3 (6%) 2 (4%)
Cyst, Multiple 1 (2%)
Degeneration, Cystic 1 (2%)
Pituitary Gland (45) (46) (45)
Cyst 1 (2%) 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Pars Distalis, Cytoplasmic Alteration, Focal 1 (2%)
Pars Intermedia, Cytomegaly 1 (2%)
Thyroid Gland (50) (48) (50)
Degeneration, Cystic 5 (10%) 10 (21%) 11 (22%)
Inflammation, Focal 1 (2%) 1 (2%)
Pigmentation 2 (4%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ductus Deferens (2)
Serosa, Foreign Body 1 (50%)
Serosa, Inflammation, Chronic 1 (50%)
Penis (1) (2) (1)
Foreign Body 1 (100%)
Inflammation, Chronic 1 (100%) 1 (100%)
Necrosis 1 (100%)
Preputial Gland (11) (13) (7)
Degeneration, Cystic 4 (36%) 8 (62%) 5 (71%)
Inflammation, Suppurative 8 (73%) 8 (62%) 4 (57%)
Prostate (50) (50) (49)
Inflammation, Suppurative 3 (6%) 1 (2%)
Seminal Vesicle (2) (3) (2)
Atrophy 1 (33%)
Dilatation 1 (50%) 1 (33%)
Fibrosis, Focal 1 (50%)
Lumen, Crystals 1 (33%)
Testes (50) (50) (50)
Angiectasis 1 (2%)
Artery, Mineralization 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05058-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ROXARSONE Date: 09/12/94
Route: DOSED FEED Time: 08:58:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.01% 0.02%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (50)
Hyperplasia, Neutrophil 1 (2%)
Lymph Node (50) (49) (50)
Axillary, Hyperplasia 1 (2%)
Axillary, Inflammation, Suppurative 1 (2%)
Inguinal, Angiectasis 2 (4%)
Inguinal, Hyperplasia 6 (12%) 2 (4%) 3 (6%)
Inguinal, Hyperplasia, Lymphoid 1 (2%)
Inguinal, Inflammation, Chronic 2 (4%)
Inguinal, Pigmentation 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%)
Lymph Node, Mandibular (48) (42) (43)
Hyperplasia 1 (2%)
Lymph Node, Mesenteric (43) (48) (47)
Angiectasis 8 (19%) 11 (23%) 11 (23%)
Hematopoietic Cell Proliferation 2 (5%)
Pigmentation 1 (2%)
Spleen (50) (50) (50)
Depletion Lymphoid 1 (2%)
Hematopoietic Cell Proliferation 16 (32%) 12 (24%) 12 (24%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Red Pulp, Depletion Cellular 1 (2%) 1 (2%)
Thymus (36) (40) (43)
Cyst 2 (6%)
Depletion Lymphoid 1 (3%)
Inflammation, Granulomatous 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50)
Cyst 1 (2%)
Exudate 2 (4%)
Fibrosis 1 (2%) 2 (4%) 1 (2%)
Hyperplasia, Basal Cell 1 (2%)
Inflammation, Chronic 19 (38%) 28 (56%) 15 (30%)
Mineralization 1 (2%) 2 (4%)
Ulcer 13 (26%) 6 (12%) 3 (6%)
Ulcer, Multiple 1 (2%)
Lip, Inflammation, Suppurative 1 (2%)
Prepuce, Inflammation, Chronic 1 (2%)
Subcutaneous Tissue, Angiectasis 1 (2%) 1 (2%)
Subcutaneous Tissue, Edema 2 (4%)
Subcutaneous Tissue, Inflammation, Chronic 1 (2%)
Subcutaneous Tissue, Inflammation,
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05058-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ROXARSONE Date: 09/12/94
Route: DOSED FEED Time: 08:58:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.01% 0.02%
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Suppurative 2 (4%) 1 (2%)
Subcutaneous Tissue, Mineralization 1 (2%)
Subcutaneous Tissue, Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (2) (2)
Artery, Head, Inflammation, Chronic 1 (100%)
Thigh, Mineralization 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Mineralization 25 (50%) 31 (62%) 26 (52%)
Artery, Meninges, Inflammation, Chronic 1 (2%)
Meninges, Hyperplasia, Lymphoid 1 (2%)
Peripheral Nerve (50) (50) (50)
Sciatic, Hyperplasia, Lymphoid 2 (4%) 1 (2%)
Spinal Cord (50) (50) (50)
Meninges, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Adenomatosis 14 (28%) 28 (56%) 24 (48%)
Congestion 1 (2%) 2 (4%)
Hemorrhage, Focal 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Hyperplasia, Macrophage 3 (6%) 3 (6%) 2 (4%)
Infiltration Cellular, Polymorphonuclear 4 (8%) 2 (4%) 5 (10%)
Inflammation, Focal 21 (42%) 31 (62%) 25 (50%)
Inflammation, Suppurative 1 (2%)
Pigmentation 2 (4%)
Alveolar Epithelium, Hyperplasia 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 5 (10%) 3 (6%) 2 (4%)
Alveolar Epithelium, Metaplasia, Focal 4 (8%) 4 (8%) 3 (6%)
Nose (48) (49) (48)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Adventitia, Inflammation, Focal 1 (2%) 1 (2%)
Adventitia, Inflammation, Suppurative 1 (2%)
Lumen, Exudate 4 (8%) 17 (35%) 2 (4%)
Lumen, Foreign Body 1 (2%) 13 (27%) 1 (2%)
Mucosa, Inflammation, Suppurative 1 (2%) 1 (2%) 4 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05058-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ROXARSONE Date: 09/12/94
Route: DOSED FEED Time: 08:58:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.01% 0.02%
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Nasolacrimal Duct, Foreign Body 1 (2%) 2 (4%)
Nasolacrimal Duct, Inflammation 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (5) (6) (4)
Hyperplasia 1 (20%)
Hyperplasia, Focal 2 (40%)
Duct, Dilatation, Focal 1 (20%) 3 (50%) 1 (25%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Autolysis 1 (2%)
Congestion 1 (2%)
Cyst 1 (2%)
Hydronephrosis 1 (2%)
Hyperplasia, Lymphoid 13 (26%) 10 (20%) 2 (4%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Inflammation, Focal 1 (2%)
Mineralization 7 (14%) 9 (18%) 17 (34%)
Nephropathy 19 (38%) 29 (58%) 25 (50%)
Pigmentation 1 (2%)
Artery, Inflammation, Chronic 2 (4%)
Capsule, Fibrosis, Focal 1 (2%)
Renal Tubule, Degeneration, Hyaline 1 (2%)
Renal Tubule, Dilatation 1 (2%) 1 (2%)
Renal Tubule, Hyperplasia, Focal 1 (2%)
Renal Tubule, Vacuolization Cytoplasmic 1 (2%)
Urethra (1) (1)
Bulbourethral Gland, Degeneration, Cystic 1 (100%)
Bulbourethral Gland, Fibrosis, Focal 1 (100%)
Bulbourethral Gland, Proliferation
Connective Tissue 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
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