TDMS Study 05058-02 Pathology Tables
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
Facility: Southern Research Institute
Chemical CAS #: 121-19-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 6| 7| 7| 4| 6| 1| 0| 7| 6| 5|
DAY ON TEST | 0| 4| 4| 2| 9| 3| 3| 3| 8| 2| 3| 3| 3| 6| 1| 4| 1| 3| 9| 8| 7| 4| 3| 5| 4|
| 2| 1| 7| 1| 2| 1| 1| 5| 8| 7| 2| 2| 2| 7| 0| 7| 0| 2| 4| 4| 0| 2| 2| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + + + + + + + + + + + + + M M + + + + + M + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + M M + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + M + + + + + + + + + + + +|
Ulcer | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | M + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 3 3 3 |
Hyperplasia, Lymphoid | |
Infarct | 3 |
Infiltration Cellular, | |
Polymorphonuclear | 2 2 2 2 3 3 3|
Vacuolization Cytoplasmic | |
Centrilobular, Vacuolization | |
Cytoplasmic | 3 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + +|
Inflammation, Suppurative | 3 3 3 3 3 3 3 4 3|
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Papillary | 1 |
Inflammation, Diffuse, Suppurative | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Artery, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 6| 7| 7| 4| 6| 1| 0| 7| 6| 5|
DAY ON TEST | 0| 4| 4| 2| 9| 3| 3| 3| 8| 2| 3| 3| 3| 6| 1| 4| 1| 3| 9| 8| 7| 4| 3| 5| 4|
| 2| 1| 7| 1| 2| 1| 1| 5| 8| 7| 2| 2| 2| 7| 0| 7| 0| 2| 4| 4| 0| 2| 2| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Infiltration Cellular, | |
Polymorphonuclear | |
Vacuolization Cytoplasmic, Focal | |
Corticomedullary Junction, | |
Degeneration, Fatty | 3 |
Extra Adrenal Tissue, Inflammation, | |
Suppurative | 2 3 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia, Focal | 1 1 |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Degeneration, Cystic | 1 1 3 2 |
Inflammation, Suppurative | 1 |
Follicular Cell, Hyperplasia | 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Bacterium | 4 |
Hyperplasia, Neutrophil | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Suppurative | 4 4 3 4 4 4 4 4 4 4|
Follicle, Cyst | X |
__________________________________________________________________________|
Oviduct | + + |
Dilatation | |
Inflammation, Suppurative | 4 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 |
Inflammation, Suppurative | 3 4 3 1 3 2 2 1 2 2|
Endometrium, Hyperplasia, Cystic | 1 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 6| 7| 7| 4| 6| 1| 0| 7| 6| 5|
DAY ON TEST | 0| 4| 4| 2| 9| 3| 3| 3| 8| 2| 3| 3| 3| 6| 1| 4| 1| 3| 9| 8| 7| 4| 3| 5| 4|
| 2| 1| 7| 1| 2| 1| 1| 5| 8| 7| 2| 2| 2| 7| 0| 7| 0| 2| 4| 4| 0| 2| 2| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Angiectasis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Bacterium | |
Bronchial, Hyperplasia | 3 |
Bronchial, Inflammation, Suppurative | |
Iliac, Hyperplasia | 2 |
Mediastinal, Cyst | |
Mediastinal, Hyperplasia | 3 |
Mediastinal, Inflammation, | |
Suppurative | 3 4 |
Renal, Hyperplasia | 3 3 3 3 3 4 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + M + + + M + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 |
Hyperplasia, Lymphoid | 2 2 |
Hyperplasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 3 3 3 4 3 3 3 2 3 3|
Hyperplasia, Lymphoid | 3 |
Infarct | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + M M + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Dilatation | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 1 |
Inflammation, Suppurative | 3 |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + |
Inflammation, Suppurative | 2 4 2 |
Adventitia, Inflammation, Focal | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 |
Hyperplasia, Lymphoid | 1 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 6| 7| 7| 4| 6| 1| 0| 7| 6| 5|
DAY ON TEST | 0| 4| 4| 2| 9| 3| 3| 3| 8| 2| 3| 3| 3| 6| 1| 4| 1| 3| 9| 8| 7| 4| 3| 5| 4|
| 2| 1| 7| 1| 2| 1| 1| 5| 8| 7| 2| 2| 2| 7| 0| 7| 0| 2| 4| 4| 0| 2| 2| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Mineralization | 2 2 1 2 3 2 1 3 1 2 2 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 |
Necrosis, Focal | 2 |
Meninges, Hyperplasia, Lymphoid | 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | 1 2 1 2 1 3 |
Congestion | 2 3 3|
Hemorrhage, Focal | 4 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Macrophage | |
Infiltration Cellular, | |
Polymorphonuclear | 2 2 3 2 2 3 |
Inflammation, Focal | 1 2 1 2 1 |
Inflammation, Suppurative | |
Mineralization | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolar Epithelium, Metaplasia, | |
Focal | |
Mediastinum, Inflammation, | |
Suppurative | 2 3 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + M M + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Hyperplasia, Lymphoid | 1 2 1 |
Infarct | |
Infiltration Cellular, | |
Polymorphonuclear | 3 |
Infiltration Cellular, Mixed Cell | 1 |
Inflammation, Suppurative | 3 |
Mineralization | |
Nephropathy | 1 1 1 2 |
Pigmentation | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 6| 7| 7| 4| 6| 1| 0| 7| 6| 5|
DAY ON TEST | 0| 4| 4| 2| 9| 3| 3| 3| 8| 2| 3| 3| 3| 6| 1| 4| 1| 3| 9| 8| 7| 4| 3| 5| 4|
| 2| 1| 7| 1| 2| 1| 1| 5| 8| 7| 2| 2| 2| 7| 0| 7| 0| 2| 4| 4| 0| 2| 2| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Capsule, Inflammation, Suppurative | 2 3 |
Renal Tubule, Degeneration, Hyaline | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 4| 5| 4| 6| 7| 7| 6| 6| 6| 5| 4| 6| 7| |
DAY ON TEST | 9| 7| 3| 2| 3| 3| 2| 3| 1| 7| 3| 1| 6| 0| 9| 8| 3| 3| 6| 2| 3| 5| 5| 8| 1| |
| 4| 6| 2| 4| 2| 2| 1| 2| 1| 6| 2| 6| 6| 8| 3| 4| 2| 2| 6| 6| 8| 6| 2| 4| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + M + +| 45 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + M M + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + M M + + + + + + + + + + + + + + + + + + + + +| 47 |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + M + + + + + + + + + + + + M + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 3 3 2 3 3 3 3| 10 2.9|
Hyperplasia, Lymphoid | 1 | 1 1.0|
Infarct | | 1 3.0|
Infiltration Cellular, | | |
Polymorphonuclear | 2 3 2 3 3 3 3 3 3 2 4 3 3 3| 21 2.7|
Vacuolization Cytoplasmic | 1 | 1 1.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + +| 27 |
Inflammation, Suppurative | 3 3 4 3 4 3 2 4 4 3 4 4 4 4| 23 3.3|
Fat, Necrosis | 2 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + M + + + + + + + + + + + + + M + + + +| 48 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Papillary | | 1 1.0|
Inflammation, Diffuse, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 3 | 1 3.0|
Artery, Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 4| 5| 4| 6| 7| 7| 6| 6| 6| 5| 4| 6| 7| |
DAY ON TEST | 9| 7| 3| 2| 3| 3| 2| 3| 1| 7| 3| 1| 6| 0| 9| 8| 3| 3| 6| 2| 3| 5| 5| 8| 1| |
| 4| 6| 2| 4| 2| 2| 1| 2| 1| 6| 2| 6| 6| 8| 3| 4| 2| 2| 6| 6| 8| 6| 2| 4| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 | 2 2.0|
Hematopoietic Cell Proliferation | 3 | 2 3.0|
Hyperplasia, Focal | 1 | 1 1.0|
Infiltration Cellular, | | |
Polymorphonuclear | 2 | 1 2.0|
Vacuolization Cytoplasmic, Focal | 3 | 1 3.0|
Corticomedullary Junction, | | |
Degeneration, Fatty | | 1 3.0|
Extra Adrenal Tissue, Inflammation, | | |
Suppurative | 4 | 4 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Developmental Malformation | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 2 | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 1 1 2 1 2| 7 1.3|
Pars Distalis, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Cyst | | 1 |
Degeneration, Cystic | 1 | 5 1.6|
Inflammation, Suppurative | | 1 1.0|
Follicular Cell, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Bacterium | | 1 4.0|
Hyperplasia, Neutrophil | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Granuloma | 3 | 1 3.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | 3 | 2 2.5|
Inflammation, Suppurative | 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4| 25 3.9|
Follicle, Cyst | X 3 X X X X X X X| 10 3.0|
__________________________________________________________________________|____________|
Oviduct | + + + + + | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 4| 5| 4| 6| 7| 7| 6| 6| 6| 5| 4| 6| 7| |
DAY ON TEST | 9| 7| 3| 2| 3| 3| 2| 3| 1| 7| 3| 1| 6| 0| 9| 8| 3| 3| 6| 2| 3| 5| 5| 8| 1| |
| 4| 6| 2| 4| 2| 2| 1| 2| 1| 6| 2| 6| 6| 8| 3| 4| 2| 2| 6| 6| 8| 6| 2| 4| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Dilatation | 3 | 1 3.0|
Inflammation, Suppurative | 3 3 3 4 | 6 3.3|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | | 1 2.0|
Inflammation, Suppurative | 4 3 3 3 3 3 3 3 3 3 3| 21 2.7|
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3 3| 46 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bronchial, Bacterium | 3 | 1 3.0|
Bronchial, Hyperplasia | | 1 3.0|
Bronchial, Inflammation, Suppurative | 3 | 1 3.0|
Iliac, Hyperplasia | | 1 2.0|
Mediastinal, Cyst | X | 1 |
Mediastinal, Hyperplasia | 3 2 3 3 3 | 6 2.8|
Mediastinal, Inflammation, | | |
Suppurative | 4 3 | 4 3.5|
Renal, Hyperplasia | 3 2 3 3 3 3 | 13 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + M + M + + M M + + + + + + + M + M + +| 40 |
Hyperplasia, Lymphoid | 3 3 | 3 3.0|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
Angiectasis | 3 3| 5 2.4|
Hyperplasia, Lymphoid | | 2 2.0|
Hyperplasia | 2 3 | 3 2.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | 3 3 3 3 3 4 3 3 3 3 3 3 3 3 3 3 3 3 3| 29 3.0|
Hyperplasia, Lymphoid | 3 | 2 3.0|
Infarct | 4 | 1 4.0|
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + M M M + + + + + + M M + + + + + M + + M + +| 39 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Dilatation | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 4| 5| 4| 6| 7| 7| 6| 6| 6| 5| 4| 6| 7| |
DAY ON TEST | 9| 7| 3| 2| 3| 3| 2| 3| 1| 7| 3| 1| 6| 0| 9| 8| 3| 3| 6| 2| 3| 5| 5| 8| 1| |
| 4| 6| 2| 4| 2| 2| 1| 2| 1| 6| 2| 6| 6| 8| 3| 4| 2| 2| 6| 6| 8| 6| 2| 4| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 2 2.0|
Inflammation, Suppurative | | 1 3.0|
Subcutaneous Tissue, Edema | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 6 |
Inflammation, Suppurative | | 3 2.7|
Adventitia, Inflammation, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Focal | | 1 2.0|
Hyperplasia, Lymphoid | | 1 1.0|
Mineralization | 2 1 1 1 2 2 2 2 2 2 1 2 2 2 1| 26 1.8|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Focal | | 1 2.0|
Necrosis, Focal | | 1 2.0|
Meninges, Hyperplasia, Lymphoid | 1 1| 4 1.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenomatosis | 1 2 2 1 1 2 1 2 1 1 2 1 2| 19 1.5|
Congestion | 2 2 2 | 6 2.3|
Hemorrhage, Focal | | 1 4.0|
Hyperplasia, Lymphoid | 2 1 2 | 4 1.8|
Hyperplasia, Macrophage | 2 | 1 2.0|
Infiltration Cellular, | | |
Polymorphonuclear | 3 3 3 2 2 3 3 3 3 3 2| 17 2.6|
Inflammation, Focal | 2 2 1 1 2 2 1 2 1 1 2 1 2| 18 1.5|
Inflammation, Suppurative | 4 | 1 4.0|
Mineralization | 2 1 | 2 1.5|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 1 3 | 3 1.7|
Alveolar Epithelium, Metaplasia, | | |
Focal | 2 1 | 2 1.5|
Mediastinum, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 4| 5| 4| 6| 7| 7| 6| 6| 6| 5| 4| 6| 7| |
DAY ON TEST | 9| 7| 3| 2| 3| 3| 2| 3| 1| 7| 3| 1| 6| 0| 9| 8| 3| 3| 6| 2| 3| 5| 5| 8| 1| |
| 4| 6| 2| 4| 2| 2| 1| 2| 1| 6| 2| 6| 6| 8| 3| 4| 2| 2| 6| 6| 8| 6| 2| 4| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Suppurative | 2 3 1 3 3 | 8 2.6|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
Hyperplasia, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 1.0|
Hyperplasia, Lymphoid | 1 1 2 1 | 7 1.3|
Infarct | 3 | 1 3.0|
Infiltration Cellular, | | |
Polymorphonuclear | 1 2 3 3 2| 6 2.3|
Infiltration Cellular, Mixed Cell | | 1 1.0|
Inflammation, Suppurative | | 1 3.0|
Mineralization | 1 | 1 1.0|
Nephropathy | 1 2 2| 7 1.4|
Pigmentation | 3 | 1 3.0|
Capsule, Inflammation, Suppurative | 2 | 3 2.3|
Renal Tubule, Degeneration, Hyaline | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 5| 5| 7| 7| 4| 7| 7| 5| 5| 7| 7| 4| 6| 5| 6| 6| 6| 4| 7| 6|
DAY ON TEST | 5| 2| 2| 7| 1| 0| 6| 0| 2| 8| 2| 2| 2| 2| 2| 2| 7| 1| 2| 0| 1| 1| 8| 2| 7|
| 9| 9| 9| 9| 4| 1| 3| 2| 9| 0| 9| 9| 2| 3| 9| 9| 7| 0| 7| 0| 0| 3| 3| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.02% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + M + + + + + + + + + + + +|
Epithelium, Degeneration, Hyaline | 4 |
Epithelium, Hyperplasia | 3 |
Serosa, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + M + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 3 2 3 3 3 3 1|
Infarct | 3 |
Infiltration Cellular, | |
Polymorphonuclear | 2 3 1 2 3 2 3 3 3 3 2 |
Inflammation, Focal | 1|
Necrosis, Focal | |
Bile Duct, Degeneration, Hyaline | 3 |
Bile Duct, Hyperplasia | 3 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 3 4 4 4 3 4 4 3 3 3 3 3 1 3|
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 |
Edema | |
Duct, Hyperplasia, Cystic | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Abdominal, Thrombosis | X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 5| 5| 7| 7| 4| 7| 7| 5| 5| 7| 7| 4| 6| 5| 6| 6| 6| 4| 7| 6|
DAY ON TEST | 5| 2| 2| 7| 1| 0| 6| 0| 2| 8| 2| 2| 2| 2| 2| 2| 7| 1| 2| 0| 1| 1| 8| 2| 7|
| 9| 9| 9| 9| 4| 1| 3| 2| 9| 0| 9| 9| 2| 3| 9| 9| 7| 0| 7| 0| 0| 3| 3| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.02% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Capsule, Inflammation, Suppurative | |
Subcapsular, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Developmental Malformation | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 1 3 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Inflammation, Suppurative | 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Follicle, Cyst | X X X X X X X X |
__________________________________________________________________________|
Oviduct | + + |
Inflammation, Suppurative | 3 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Inflammation, Suppurative | 3 3 3 3 1 3 4 3 1 3 3 1|
Thrombosis | X |
Endometrium, Hyperplasia, Cystic | 2 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 1 3 3|
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Hyperplasia | 3 3 |
Bronchial, Inflammation, Suppurative | 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 5| 5| 7| 7| 4| 7| 7| 5| 5| 7| 7| 4| 6| 5| 6| 6| 6| 4| 7| 6|
DAY ON TEST | 5| 2| 2| 7| 1| 0| 6| 0| 2| 8| 2| 2| 2| 2| 2| 2| 7| 1| 2| 0| 1| 1| 8| 2| 7|
| 9| 9| 9| 9| 4| 1| 3| 2| 9| 0| 9| 9| 2| 3| 9| 9| 7| 0| 7| 0| 0| 3| 3| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.02% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Hyperplasia, Lymphoid | 3 |
Iliac, Hyperplasia | 3 3 3 |
Iliac, Inflammation, Suppurative | |
Inguinal, Hyperplasia, Lymphoid | |
Lumbar, Hyperplasia | 3 |
Mediastinal, Hyperplasia | 2 3|
Mediastinal, Inflammation, | |
Suppurative | 2 |
Pancreatic, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia | |
Renal, Angiectasis | 2 |
Renal, Hyperplasia, Lymphoid | 3 |
Renal, Hyperplasia | 3 3 4 4 3 4|
Renal, Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia | 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + + + +|
Angiectasis | 2 3 2 2 2 2|
Hematopoietic Cell Proliferation | |
Hyperplasia | 3 3|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 3 3 3 3 3 3 4 3 4 2 3|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + M + + M + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Dilatation | 3 2 3 2 1 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Inflammation, | |
Suppurative | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
Inflammation, Suppurative | 4 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 2 3 |
Mineralization | 2 1 2 2 1 1 1 2|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 5| 5| 7| 7| 4| 7| 7| 5| 5| 7| 7| 4| 6| 5| 6| 6| 6| 4| 7| 6|
DAY ON TEST | 5| 2| 2| 7| 1| 0| 6| 0| 2| 8| 2| 2| 2| 2| 2| 2| 7| 1| 2| 0| 1| 1| 8| 2| 7|
| 9| 9| 9| 9| 4| 1| 3| 2| 9| 0| 9| 9| 2| 3| 9| 9| 7| 0| 7| 0| 0| 3| 3| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.02% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Ventricle, Mineralization, Focal | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sciatic, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Hyperplasia, Lymphoid | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | 2 1 2 1 2 1 1 |
Congestion | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Macrophage | 1 |
Infiltration Cellular, | |
Polymorphonuclear | 3 3 3 1 3 1 |
Inflammation, Focal | 2 2 1 2 1 1 |
Inflammation, Suppurative | 3 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolar Epithelium, Metaplasia, | |
Focal | 1 |
Mediastinum, Inflammation, | |
Suppurative | 3 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Nasolacrimal Duct, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Dilatation | 2 |
Glands, Exudate | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
Foreign Body | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia, Lymphoid | 1 |
Infiltration Cellular, | |
Polymorphonuclear | 2 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Multifocal | 3 2 |
Inflammation, Suppurative | |
Metaplasia, Osseous | |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 5| 5| 7| 7| 4| 7| 7| 5| 5| 7| 7| 4| 6| 5| 6| 6| 6| 4| 7| 6|
DAY ON TEST | 5| 2| 2| 7| 1| 0| 6| 0| 2| 8| 2| 2| 2| 2| 2| 2| 7| 1| 2| 0| 1| 1| 8| 2| 7|
| 9| 9| 9| 9| 4| 1| 3| 2| 9| 0| 9| 9| 2| 3| 9| 9| 7| 0| 7| 0| 0| 3| 3| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.02% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | |
Capsule, Inflammation, Suppurative | 2 3 3|
Glomerulus, Inflammation | 3|
Papilla, Necrosis | |
__________________________________________________________________________|
Urethra | |
Inflammation, Suppurative | |
Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 4| 6| 4| 5| 7| 5| 5| 7| 7| 7| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 4| 5| 5| 5| |
DAY ON TEST | 3| 0| 8| 6| 2| 0| 3| 3| 3| 3| 8| 3| 3| 0| 1| 3| 9| 1| 3| 3| 6| 8| 8| 6| 9| |
| 5| 6| 6| 2| 9| 7| 4| 0| 0| 0| 5| 0| 0| 1| 8| 0| 1| 0| 0| 0| 1| 5| 1| 1| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.02% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | M + M + + + + + + + + + + + + + + + + + + + + + +| 47 |
Epithelium, Degeneration, Hyaline | | 1 4.0|
Epithelium, Hyperplasia | | 1 3.0|
Serosa, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + M + + + M + + + + + + A + + + + + + + + + + M| 46 |
Edema | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + M + + + + + + + + + + A + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + A + + + + + + + + + + A| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + A| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + + + + + + + + + + + A + + + + + + + + + + A| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + M + + + + + + + + + + A + + + + + + + + + + A| 46 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 3 2 3 3 3 2 2 2 2 4| 18 2.6|
Infarct | | 1 3.0|
Infiltration Cellular, | | |
Polymorphonuclear | 3 3 3 3 2 3 2 2 2 | 20 2.5|
Inflammation, Focal | | 1 1.0|
Necrosis, Focal | 1 | 1 1.0|
Bile Duct, Degeneration, Hyaline | | 1 3.0|
Bile Duct, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + +| 30 |
Inflammation, Suppurative | 4 4 2 4 3 4 4 4 4 4 4 4 4 4| 29 3.5|
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
Atrophy, Focal | 1 | 2 1.5|
Edema | 3 | 1 3.0|
Duct, Hyperplasia, Cystic | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + M + + + + + + + + + + M + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 4| 6| 4| 5| 7| 5| 5| 7| 7| 7| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 4| 5| 5| 5| |
DAY ON TEST | 3| 0| 8| 6| 2| 0| 3| 3| 3| 3| 8| 3| 3| 0| 1| 3| 9| 1| 3| 3| 6| 8| 8| 6| 9| |
| 5| 6| 6| 2| 9| 7| 4| 0| 0| 0| 5| 0| 0| 1| 8| 0| 1| 0| 0| 0| 1| 5| 1| 1| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.02% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Abdominal, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 1 1.0|
Artery, Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Capsule, Inflammation, Suppurative | 3 | 1 3.0|
Subcapsular, Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Developmental Malformation | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + M + + + + +| 47 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + I + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Hyperplasia, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Degeneration, Cystic | 2 3 1 1 | 8 1.8|
Inflammation, Suppurative | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Inflammation, Suppurative | 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4| 29 4.0|
Follicle, Cyst | X X X X X X X X X | 17 |
__________________________________________________________________________|____________|
Oviduct | + | 3 |
Inflammation, Suppurative | 3 | 3 2.7|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Inflammation, Suppurative | 1 3 4 4 3 3 2 2 3 4 3| 23 2.7|
Thrombosis | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 4| 6| 4| 5| 7| 5| 5| 7| 7| 7| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 4| 5| 5| 5| |
DAY ON TEST | 3| 0| 8| 6| 2| 0| 3| 3| 3| 3| 8| 3| 3| 0| 1| 3| 9| 1| 3| 3| 6| 8| 8| 6| 9| |
| 5| 6| 6| 2| 9| 7| 4| 0| 0| 0| 5| 0| 0| 1| 8| 0| 1| 0| 0| 0| 1| 5| 1| 1| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.02% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 2 3 4 3 3 3 3 3 3 3 3 3 3 3 3 2 2 3 3| 48 2.9|
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Myelofibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bronchial, Hyperplasia | 3 | 3 3.0|
Bronchial, Inflammation, Suppurative | | 3 3.0|
Iliac, Hyperplasia, Lymphoid | | 1 3.0|
Iliac, Hyperplasia | 4 3 2 3 3 | 8 3.0|
Iliac, Inflammation, Suppurative | 3 | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Lumbar, Hyperplasia | 3 3 | 3 3.0|
Mediastinal, Hyperplasia | 3 2 2 3 3 | 7 2.6|
Mediastinal, Inflammation, | | |
Suppurative | 3 3 3 4 | 5 3.0|
Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0|
Pancreatic, Hyperplasia | 3 | 1 3.0|
Renal, Angiectasis | | 1 2.0|
Renal, Hyperplasia, Lymphoid | | 1 3.0|
Renal, Hyperplasia | 3 3 3 3 2 3 4 3 3 3 | 16 3.2|
Renal, Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + + + M + + M + M + M + + + M + + +| 42 |
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia | 3 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M M + + M + + + + + + + + + + +| 46 |
Angiectasis | 3 3 3 2 | 10 2.4|
Hematopoietic Cell Proliferation | 3 2 | 2 2.5|
Hyperplasia | 3 | 3 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 3 3 3 3 3 3 3 3 3 4 3 3 3 3 3 4| 31 3.1|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + + + + + M + + + + + + + M +| 44 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Dilatation | 1 1 1 3 | 10 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 4| 6| 4| 5| 7| 5| 5| 7| 7| 7| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 4| 5| 5| 5| |
DAY ON TEST | 3| 0| 8| 6| 2| 0| 3| 3| 3| 3| 8| 3| 3| 0| 1| 3| 9| 1| 3| 3| 6| 8| 8| 6| 9| |
| 5| 6| 6| 2| 9| 7| 4| 0| 0| 0| 5| 0| 0| 1| 8| 0| 1| 0| 0| 0| 1| 5| 1| 1| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.02% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 4 | 3 2.3|
Subcutaneous Tissue, Edema | 3 | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Inflammation, Suppurative | | 2 3.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 3 3.0|
Mineralization | 2 1 3 2 2 2 1 2 3 2 1 | 19 1.7|
Ventricle, Mineralization, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sciatic, Hyperplasia, Lymphoid | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Meninges, Hyperplasia, Lymphoid | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenomatosis | 1 1 2 1 1 1 | 13 1.3|
Congestion | 3 3 | 2 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Macrophage | 1 | 2 1.0|
Infiltration Cellular, | | |
Polymorphonuclear | 3 3 2 2 3 3 2 3 4| 15 2.6|
Inflammation, Focal | 1 1 2 1 1 1 | 12 1.3|
Inflammation, Suppurative | 2 3 | 4 2.8|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 1 1.0|
Alveolar Epithelium, Metaplasia, | | |
Focal | | 1 1.0|
Mediastinum, Inflammation, | | |
Suppurative | 4 4 3 3 | 7 3.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 4| 6| 4| 5| 7| 5| 5| 7| 7| 7| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 4| 5| 5| 5| |
DAY ON TEST | 3| 0| 8| 6| 2| 0| 3| 3| 3| 3| 8| 3| 3| 0| 1| 3| 9| 1| 3| 3| 6| 8| 8| 6| 9| |
| 5| 6| 6| 2| 9| 7| 4| 0| 0| 0| 5| 0| 0| 1| 8| 0| 1| 0| 0| 0| 1| 5| 1| 1| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.02% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Nasolacrimal Duct, Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Glands, Dilatation | | 1 2.0|
Glands, Exudate | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Foreign Body | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
Fibrosis | 2| 1 2.0|
Hyperplasia, Lymphoid | | 1 1.0|
Infiltration Cellular, | | |
Polymorphonuclear | | 1 2.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Inflammation, Multifocal | | 2 2.5|
Inflammation, Suppurative | 3| 1 3.0|
Metaplasia, Osseous | 2 | 1 2.0|
Mineralization | 2| 1 2.0|
Nephropathy | 1 3 2 | 3 2.0|
Capsule, Inflammation, Suppurative | 3 3 | 5 2.8|
Glomerulus, Inflammation | 2 3 | 3 2.7|
Papilla, Necrosis | 3| 1 3.0|
__________________________________________________________________________|____________|
Urethra | + | 1 |
Inflammation, Suppurative | 3 | 1 3.0|
Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 4| 5| 6| 6| 5| 6| 7| 6| 5| 7| 7| 5| 6| 5| 7| 5| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 9| 8| 5| 5| 0| 3| 0| 3| 1| 3| 3| 2| 1| 3| 3| 3| 3| 8|
| 1| 1| 1| 1| 1| 1| 8| 2| 3| 0| 7| 7| 2| 7| 7| 2| 1| 1| 1| 2| 0| 1| 2| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.01% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + M + + + M + M + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perforation | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 2 3 2 3 2 3 3 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, | |
Polymorphonuclear | 3 2 3 3 2 2 2 3 3 3 3 3 2 |
Inflammation, Focal | 2 |
Necrosis, Focal | 1 |
Necrosis, Multifocal | |
Vacuolization Cytoplasmic | |
Serosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 2 3 4 4 4 3 4 4 3 3 4 3 3 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Papillary | 1 1 3 3 |
Inflammation, Focal | 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Necrosis, Focal | 3 |
Pigmentation | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + M + + + + + + + + + + + + + + + +|
Congestion | 2 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 4| 5| 6| 6| 5| 6| 7| 6| 5| 7| 7| 5| 6| 5| 7| 5| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 9| 8| 5| 5| 0| 3| 0| 3| 1| 3| 3| 2| 1| 3| 3| 3| 3| 8|
| 1| 1| 1| 1| 1| 1| 8| 2| 3| 0| 7| 7| 2| 7| 7| 2| 1| 1| 1| 2| 0| 1| 2| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.01% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Capsule, Inflammation, Suppurative | |
Extra Adrenal Tissue, Inflammation, | |
Suppurative | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + M + M + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Degeneration, Cystic | 1 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + M + + + + + + + +|
Inflammation, Suppurative | 4 3 3 4 4 4 3 4 3 4 4 3 4 4 4 |
Follicle, Cyst | X X X X X X X X|
__________________________________________________________________________|
Oviduct | + + |
Inflammation, Suppurative | 4 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | |
Inflammation, Suppurative | 2 1 1 3 3 3 3 3 3 3 3 3 3 3 3 2 4 4 1 |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 3 2 3 3 3 3 2 3 3 3 3 3 3 2 3 2 3 1 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Mediastinal, Hyperplasia | |
Iliac, Hyperplasia | 3 3 3 |
Inguinal, Hyperplasia | 1 |
Lumbar, Hyperplasia | |
Mediastinal, Hyperplasia | 3 |
Renal, Hyperplasia | 3 3 3 4 3 3 4 3 4 3 |
Renal, Inflammation, Suppurative | 3 |
Renal, Mediastinal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 4| 5| 6| 6| 5| 6| 7| 6| 5| 7| 7| 5| 6| 5| 7| 5| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 9| 8| 5| 5| 0| 3| 0| 3| 1| 3| 3| 2| 1| 3| 3| 3| 3| 8|
| 1| 1| 1| 1| 1| 1| 8| 2| 3| 0| 7| 7| 2| 7| 7| 2| 1| 1| 1| 2| 0| 1| 2| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.01% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Angiectasis | 2 2 2 2|
Hyperplasia, Lymphoid | |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 3 3 3 2 3 3 3 3 3 3 3 2 3 |
Hyperplasia, Lymphoid | 2 |
Red Pulp, Depletion Cellular | |
__________________________________________________________________________|
Thymus | M + + + + + M + + + + + + + + + + M M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Dilatation | 2 2 1 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Fibrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Suppurative | 2 |
Adventitia, Inflammation, Focal | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Mineralization | 1 2 1 2 2 2 2 1 2 2 1 1|
Meninges, Inflammation, Chronic | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Hyperplasia, Lymphoid | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | 2 1 1 1 1 1 2 1 1 2 |
Congestion | 2 |
Hemorrhage, Focal | 1 |
Hyperplasia, Lymphoid | 1 1 1 |
Hyperplasia, Macrophage | 1 1 |
Infiltration Cellular, | |
Polymorphonuclear | 2 2 2 3 3 |
Inflammation, Focal | 2 1 1 1 1 1 2 1 1 1 2 |
Inflammation, Suppurative | 3 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 4| 5| 6| 6| 5| 6| 7| 6| 5| 7| 7| 5| 6| 5| 7| 5| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 9| 8| 5| 5| 0| 3| 0| 3| 1| 3| 3| 2| 1| 3| 3| 3| 3| 8|
| 1| 1| 1| 1| 1| 1| 8| 2| 3| 0| 7| 7| 2| 7| 7| 2| 1| 1| 1| 2| 0| 1| 2| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.01% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolar Epithelium, Metaplasia, | |
Focal | 1 |
Mediastinum, Inflammation, | |
Suppurative | 3 3 4 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Exudate | 1 |
Lumen, Foreign Body | 1 |
Mucosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia, Lymphoid | 1 |
Infiltration Cellular, | |
Polymorphonuclear | 2 |
Infiltration Cellular, Mixed Cell | 2 2 |
Inflammation, Suppurative | |
Mineralization | 1 1 1 |
Nephropathy | 1 1 |
Capsule, Inflammation, Suppurative | 3 3 3 3 2 3 2 4 |
Papilla, Necrosis | |
Renal Tubule, Vacuolization | |
Cytoplasmic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 6| 7| 4| 6| 7| 7| 6| 6| 7| 5| 5| 5| 7| 5| 5| 4| 7| 6| 6| 6| 5| 7| 6| 6| 7| |
DAY ON TEST | 3| 3| 9| 0| 3| 3| 6| 5| 3| 1| 0| 0| 3| 3| 2| 9| 3| 3| 2| 5| 2| 3| 1| 7| 3| |
| 9| 1| 0| 1| 1| 1| 2| 8| 1| 8| 4| 4| 1| 2| 2| 4| 1| 4| 6| 0| 1| 1| 4| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.01% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + + + + + + + + + + + + + + + + + + M + +| 45 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + M M + + + + + + + + + + + + + + + + + + + M| 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Perforation | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 3 3 1 3 3 2 1 3 3 2 | 20 2.5|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Infiltration Cellular, | | |
Polymorphonuclear | 3 3 2 2 3 3 3 1 3 2 3 | 24 2.6|
Inflammation, Focal | | 1 2.0|
Necrosis, Focal | 2 1 | 3 1.3|
Necrosis, Multifocal | 1 | 1 1.0|
Vacuolization Cytoplasmic | 3 | 1 3.0|
Serosa, Inflammation, Suppurative | 2 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + | 27 |
Inflammation, Suppurative | 3 3 3 3 3 3 4 4 4 4 3 | 25 3.4|
Fat, Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Papillary | 1 2 | 6 1.8|
Inflammation, Focal | 2 | 3 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 2.0|
Necrosis, Focal | | 1 3.0|
Pigmentation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 6| 7| 4| 6| 7| 7| 6| 6| 7| 5| 5| 5| 7| 5| 5| 4| 7| 6| 6| 6| 5| 7| 6| 6| 7| |
DAY ON TEST | 3| 3| 9| 0| 3| 3| 6| 5| 3| 1| 0| 0| 3| 3| 2| 9| 3| 3| 2| 5| 2| 3| 1| 7| 3| |
| 9| 1| 0| 1| 1| 1| 2| 8| 1| 8| 4| 4| 1| 2| 2| 4| 1| 4| 6| 0| 1| 1| 4| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.01% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | | 1 2.0|
Inflammation, Suppurative | 3 | 1 3.0|
Capsule, Inflammation, Suppurative | 3 | 1 3.0|
Extra Adrenal Tissue, Inflammation, | | |
Suppurative | 3 | 2 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + + + + + + + + + + + + + + + + + + + + M| 44 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + M + + + + M + + + + + + + + + +| 46 |
Pars Distalis, Hyperplasia, Focal | 2 1 1 | 5 1.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 2 |
Degeneration, Cystic | | 2 1.0|
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 4 4 2 4 4 3 4 3 4 4 4 4 4 4 | 29 3.7|
Follicle, Cyst | X X X X X X X X X X | 18 |
__________________________________________________________________________|____________|
Oviduct | + | 3 |
Inflammation, Suppurative | 3 | 3 3.7|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 3 | 1 3.0|
Inflammation, Suppurative | 2 3 2 3 3 3 3 3 3 2 2 2 2 3 | 33 2.6|
Endometrium, Hyperplasia, Cystic | 2 3 3 2 3 3 4 3 3 3 3 3 3 4 3 3 3 3 3 2 3 2 3 3| 49 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 6| 7| 4| 6| 7| 7| 6| 6| 7| 5| 5| 5| 7| 5| 5| 4| 7| 6| 6| 6| 5| 7| 6| 6| 7| |
DAY ON TEST | 3| 3| 9| 0| 3| 3| 6| 5| 3| 1| 0| 0| 3| 3| 2| 9| 3| 3| 2| 5| 2| 3| 1| 7| 3| |
| 9| 1| 0| 1| 1| 1| 2| 8| 1| 8| 4| 4| 1| 2| 2| 4| 1| 4| 6| 0| 1| 1| 4| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.01% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Bronchial, Mediastinal, Hyperplasia | 2 | 1 2.0|
Iliac, Hyperplasia | 4 | 4 3.3|
Inguinal, Hyperplasia | | 1 1.0|
Lumbar, Hyperplasia | 4 | 1 4.0|
Mediastinal, Hyperplasia | 3 2 3 3 2 3 | 7 2.7|
Renal, Hyperplasia | 2 3 4 4 | 14 3.3|
Renal, Inflammation, Suppurative | | 1 3.0|
Renal, Mediastinal, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
Angiectasis | 1 3 | 6 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Hyperplasia | 2 3 | 4 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 3 3 3 3 2 3 3 3 3 3 2 3 3 | 30 2.9|
Hyperplasia, Lymphoid | 2 | 2 2.0|
Red Pulp, Depletion Cellular | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + + M + + + + M + + + + M + +| 42 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Dilatation | 1 1 1 | 7 1.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 4 | 2 3.5|
Subcutaneous Tissue, Edema | 1 | 1 1.0|
Subcutaneous Tissue, Fibrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Inflammation, Suppurative | 3 | 2 2.5|
Adventitia, Inflammation, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Compression | X | 1 |
Mineralization | 1 1 2 1 1 1 1 2 2 2 2 2 2| 25 1.6|
Meninges, Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 6| 7| 4| 6| 7| 7| 6| 6| 7| 5| 5| 5| 7| 5| 5| 4| 7| 6| 6| 6| 5| 7| 6| 6| 7| |
DAY ON TEST | 3| 3| 9| 0| 3| 3| 6| 5| 3| 1| 0| 0| 3| 3| 2| 9| 3| 3| 2| 5| 2| 3| 1| 7| 3| |
| 9| 1| 0| 1| 1| 1| 2| 8| 1| 8| 4| 4| 1| 2| 2| 4| 1| 4| 6| 0| 1| 1| 4| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.01% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Meninges, Hyperplasia, Lymphoid | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenomatosis | 1 2 1 1 1 2 1 2 2 2 1 1 2 | 23 1.4|
Congestion | 1 | 2 1.5|
Hemorrhage, Focal | | 1 1.0|
Hyperplasia, Lymphoid | 1 | 4 1.0|
Hyperplasia, Macrophage | 1 | 3 1.0|
Infiltration Cellular, | | |
Polymorphonuclear | 3 2 2 2 3 3 2 1 3 | 14 2.4|
Inflammation, Focal | 1 2 1 1 1 2 1 2 2 1 | 21 1.3|
Inflammation, Suppurative | 3 3 2 | 4 2.8|
Thrombosis | X | 1 |
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 1 1 | 4 1.3|
Alveolar Epithelium, Metaplasia, | | |
Focal | 1 | 2 1.0|
Mediastinum, Inflammation, | | |
Suppurative | 3 3 3 | 7 3.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Exudate | 1 1 2 | 4 1.3|
Lumen, Foreign Body | 1 | 2 1.0|
Mucosa, Inflammation, Suppurative | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Hyperplasia, Lymphoid | | 1 1.0|
Infiltration Cellular, | | |
Polymorphonuclear | 2 | 2 2.0|
Infiltration Cellular, Mixed Cell | 2 2 | 4 2.0|
Inflammation, Suppurative | 3 | 1 3.0|
Mineralization | 1 | 4 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 6| 7| 4| 6| 7| 7| 6| 6| 7| 5| 5| 5| 7| 5| 5| 4| 7| 6| 6| 6| 5| 7| 6| 6| 7| |
DAY ON TEST | 3| 3| 9| 0| 3| 3| 6| 5| 3| 1| 0| 0| 3| 3| 2| 9| 3| 3| 2| 5| 2| 3| 1| 7| 3| |
| 9| 1| 0| 1| 1| 1| 2| 8| 1| 8| 4| 4| 1| 2| 2| 4| 1| 4| 6| 0| 1| 1| 4| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.01% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy | 1 1 | 4 1.0|
Capsule, Inflammation, Suppurative | 3 1 3 3 | 12 2.8|
Papilla, Necrosis | 3 | 1 3.0|
Renal Tubule, Vacuolization | | |
Cytoplasmic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| 5| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 6| 3| 8| 5| 3| 3| 3| 3| 1| 2| 1| 1| 3| 3| 1| 3| 3| 1|
| 1| 1| 1| 1| 1| 1| 1| 6| 1| 6| 1| 1| 1| 8| 1| 8| 3| 9| 6| 1| 1| 5| 1| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + M M M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + M + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Cyst | X |
Developmental Malformation | |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 2 |
Infarct | |
Infiltration Cellular, | |
Polymorphonuclear | |
Mineralization, Focal | |
Necrosis, Focal | 1 |
Necrosis, Multifocal | |
Nuclear Alteration | |
Thrombosis | |
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + |
Hemorrhage | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 |
Edema | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Papillary | 2 |
Inflammation, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
__________________________________________________________________________|
Tooth | + + + + + + + + |
Incisor, Dysplasia | 4 3 3 1 2 2 |
Incisor, Inflammation, Suppurative | 3 3 3 2 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| 5| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 6| 3| 8| 5| 3| 3| 3| 3| 1| 2| 1| 1| 3| 3| 1| 3| 3| 1|
| 1| 1| 1| 1| 1| 1| 1| 6| 1| 6| 1| 1| 1| 8| 1| 8| 3| 9| 6| 1| 1| 5| 1| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mesenteric Artery, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, | |
Polymorphonuclear | |
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infiltration Cellular, | |
Polymorphonuclear | |
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
Infiltration Cellular, | |
Polymorphonuclear | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + M + + + + + + + +|
Cyst | X X X |
Degeneration, Cystic | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Cyst | X |
Infiltration Cellular, | |
Polymorphonuclear | |
Pars Intermedia, Cytomegaly | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 3 2 1|
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ductus Deferens | |
Serosa, Foreign Body | |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
Foreign Body | 3 |
Inflammation, Chronic | 3 |
Necrosis | 3 |
__________________________________________________________________________|
Preputial Gland | + + + |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| 5| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 6| 3| 8| 5| 3| 3| 3| 3| 1| 2| 1| 1| 3| 3| 1| 3| 3| 1|
| 1| 1| 1| 1| 1| 1| 1| 6| 1| 6| 1| 1| 1| 8| 1| 8| 3| 9| 6| 1| 1| 5| 1| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Degeneration, Cystic | 2 |
Inflammation, Suppurative | 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 4 |
__________________________________________________________________________|
Seminal Vesicle | + |
Dilatation | |
Fibrosis, Focal | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Inflammation, Suppurative | 3 |
Inguinal, Hyperplasia | 3 3 4 |
Inguinal, Inflammation, Chronic | 3 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + M + + + + + M + + + + + M + +|
Angiectasis | 1 1 1 3 |
Hematopoietic Cell Proliferation | 3 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 3 3 3 3 3 3 3|
Infiltration Cellular, | |
Polymorphonuclear | |
Red Pulp, Depletion Cellular | 2 |
__________________________________________________________________________|
Thymus | + + + + + + M M + M + + M M + M M + M + + + + + M|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M + M M M M + M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 3 |
Fibrosis | 3 |
Inflammation, Chronic | 2 3 3 3 2 1 3 1 3 2 2 3|
Mineralization | |
Ulcer | 3 3 3 2 3 1 3|
Ulcer, Multiple | 3 |
Prepuce, Inflammation, Chronic | |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| 5| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 6| 3| 8| 5| 3| 3| 3| 3| 1| 2| 1| 1| 3| 3| 1| 3| 3| 1|
| 1| 1| 1| 1| 1| 1| 1| 6| 1| 6| 1| 1| 1| 8| 1| 8| 3| 9| 6| 1| 1| 5| 1| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Artery, Head, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, | |
Polymorphonuclear | |
Mineralization | 3 2 2 2 1 1 1 2 2 2 2 1 2 2|
Artery, Meninges, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sciatic, Hyperplasia, Lymphoid | 1 1 |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | 2 1 1 2 3 2 2|
Congestion | |
Hemorrhage, Focal | 2 |
Hyperplasia, Lymphoid | 1 |
Hyperplasia, Macrophage | 2 |
Infiltration Cellular, | |
Polymorphonuclear | 3 2 |
Inflammation, Focal | 1 2 1 1 2 2 3 1 2|
Pigmentation | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 1 1 1 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolar Epithelium, Metaplasia, | |
Focal | 1 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, | |
Polymorphonuclear | |
Adventitia, Inflammation, Focal | 2 |
Lumen, Exudate | 2 2 X |
Lumen, Foreign Body | 1 |
Mucosa, Inflammation, Suppurative | |
Nasolacrimal Duct, Foreign Body | 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| 5| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 6| 3| 8| 5| 3| 3| 3| 3| 1| 2| 1| 1| 3| 3| 1| 3| 3| 1|
| 1| 1| 1| 1| 1| 1| 1| 6| 1| 6| 1| 1| 1| 8| 1| 8| 3| 9| 6| 1| 1| 5| 1| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia, Focal | 2 |
Hyperplasia | |
Duct, Dilatation, Focal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 1 1 1 1 1 |
Infiltration Cellular, | |
Polymorphonuclear | |
Inflammation, Focal | 1 |
Mineralization | 1 2 1 1 1|
Nephropathy | 1 1 1 1 1 1 1 1 1|
Artery, Inflammation, Chronic | |
Renal Tubule, Degeneration, Hyaline | |
Renal Tubule, Dilatation | |
Renal Tubule, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Urethra | |
Bulbourethral Gland, Proliferation | |
Connective Tissue | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 4| 6| 7| 2| 5| 7| 4| 7| 7| 7| 6| 7| 2| 7| |
DAY ON TEST | 3| 3| 3| 5| 0| 6| 3| 3| 3| 3| 4| 5| 5| 3| 9| 3| 3| 7| 3| 1| 3| 6| 3| 2| 1| |
| 1| 1| 1| 3| 1| 8| 2| 2| 2| 2| 7| 6| 3| 2| 9| 5| 2| 0| 2| 5| 2| 5| 2| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + M + + M + + + + M + + M M| 42 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + M + +| 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + M + + + M + + + + + + M + + + + + M +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | 2 | 1 2.0|
Cyst | | 1 |
Developmental Malformation | 1 | 1 1.0|
Fibrosis, Focal | 2 3 | 2 2.5|
Hematopoietic Cell Proliferation | | 1 2.0|
Infarct | 3 | 1 3.0|
Infiltration Cellular, | | |
Polymorphonuclear | 4 | 1 4.0|
Mineralization, Focal | 3 | 1 3.0|
Necrosis, Focal | 2 | 2 1.5|
Necrosis, Multifocal | 2 | 1 2.0|
Nuclear Alteration | 2 | 1 2.0|
Thrombosis | X | 1 |
Centrilobular, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Atrophy, Focal | | 1 1.0|
Edema | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Papillary | | 1 2.0|
Inflammation, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + | 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 4| 6| 7| 2| 5| 7| 4| 7| 7| 7| 6| 7| 2| 7| |
DAY ON TEST | 3| 3| 3| 5| 0| 6| 3| 3| 3| 3| 4| 5| 5| 3| 9| 3| 3| 7| 3| 1| 3| 6| 3| 2| 1| |
| 1| 1| 1| 3| 1| 8| 2| 2| 2| 2| 7| 6| 3| 2| 9| 5| 2| 0| 2| 5| 2| 5| 2| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Incisor, Dysplasia | 2 1 1 2 2 2 | 12 2.1|
Incisor, Inflammation, Suppurative | 3 1 3 | 8 2.4|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Mesenteric Artery, Inflammation, | | |
Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
Artery, Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
Vacuolization Cytoplasmic, Focal | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 1 1.0|
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 47 |
Cyst | | 3 |
Degeneration, Cystic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + M + + + M + M + + + + + + + + +| 45 |
Cyst | | 1 |
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
Pars Intermedia, Cytomegaly | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 3 | 5 2.2|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 4| 6| 7| 2| 5| 7| 4| 7| 7| 7| 6| 7| 2| 7| |
DAY ON TEST | 3| 3| 3| 5| 0| 6| 3| 3| 3| 3| 4| 5| 5| 3| 9| 3| 3| 7| 3| 1| 3| 6| 3| 2| 1| |
| 1| 1| 1| 3| 1| 8| 2| 2| 2| 2| 7| 6| 3| 2| 9| 5| 2| 0| 2| 5| 2| 5| 2| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Ductus Deferens | + + | 2 |
Serosa, Foreign Body | 3 | 1 3.0|
Serosa, Inflammation, Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Penis | | 1 |
Foreign Body | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 11 |
Degeneration, Cystic | 3 1 1 | 4 1.8|
Inflammation, Suppurative | 3 3 4 3 4 4 | 8 3.4|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 3 | 3 3.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 2 |
Dilatation | 3 | 1 3.0|
Fibrosis, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Neutrophil | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Inflammation, Suppurative | | 1 3.0|
Inguinal, Hyperplasia | 2 1 3 | 6 2.7|
Inguinal, Inflammation, Chronic | 3 | 2 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + M + + + M + + +| 43 |
Angiectasis | 3 2 2 2 | 8 1.9|
Hematopoietic Cell Proliferation | | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 3 3 3 2 3 | 16 2.9|
Infiltration Cellular, | | |
Polymorphonuclear | 4 | 1 4.0|
Red Pulp, Depletion Cellular | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + M M + + + + + M + + + + + M +| 36 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 4| 6| 7| 2| 5| 7| 4| 7| 7| 7| 6| 7| 2| 7| |
DAY ON TEST | 3| 3| 3| 5| 0| 6| 3| 3| 3| 3| 4| 5| 5| 3| 9| 3| 3| 7| 3| 1| 3| 6| 3| 2| 1| |
| 1| 1| 1| 3| 1| 8| 2| 2| 2| 2| 7| 6| 3| 2| 9| 5| 2| 0| 2| 5| 2| 5| 2| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Cyst | X X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M + M M M M M M M M| 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | 1 | 2 2.0|
Fibrosis | | 1 3.0|
Inflammation, Chronic | 3 1 3 3 2 3 3 | 19 2.4|
Mineralization | 3 | 1 3.0|
Ulcer | 3 3 3 3 1 3| 13 2.6|
Ulcer, Multiple | | 1 3.0|
Prepuce, Inflammation, Chronic | 4 | 1 4.0|
Subcutaneous Tissue, Edema | 2 3 | 2 2.5|
Subcutaneous Tissue, Inflammation, | | |
Suppurative | 3 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Artery, Head, Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
Mineralization | 1 2 1 2 2 2 2 2 2 1 2 | 25 1.8|
Artery, Meninges, Inflammation, | | |
Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sciatic, Hyperplasia, Lymphoid | | 2 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenomatosis | 1 1 1 2 2 2 1| 14 1.6|
Congestion | 3 | 1 3.0|
Hemorrhage, Focal | | 1 2.0|
Hyperplasia, Lymphoid | | 1 1.0|
Hyperplasia, Macrophage | 1 1 | 3 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 4| 6| 7| 2| 5| 7| 4| 7| 7| 7| 6| 7| 2| 7| |
DAY ON TEST | 3| 3| 3| 5| 0| 6| 3| 3| 3| 3| 4| 5| 5| 3| 9| 3| 3| 7| 3| 1| 3| 6| 3| 2| 1| |
| 1| 1| 1| 3| 1| 8| 2| 2| 2| 2| 7| 6| 3| 2| 9| 5| 2| 0| 2| 5| 2| 5| 2| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Infiltration Cellular, | | |
Polymorphonuclear | 4 3 | 4 3.0|
Inflammation, Focal | 1 1 1 3 1 1 1 2 1 2 2 1| 21 1.5|
Pigmentation | 1 1 | 2 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 5 1.4|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolar Epithelium, Metaplasia, | | |
Focal | 1 | 4 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + M + + + + + + + + M +| 48 |
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
Adventitia, Inflammation, Focal | | 1 2.0|
Lumen, Exudate | 2 | 4 2.0|
Lumen, Foreign Body | | 1 1.0|
Mucosa, Inflammation, Suppurative | 3 | 1 3.0|
Nasolacrimal Duct, Foreign Body | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + +| 5 |
Hyperplasia, Focal | 1| 2 1.5|
Hyperplasia | 2 | 1 2.0|
Duct, Dilatation, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 1 1 1 1 1 2 1| 13 1.1|
Infiltration Cellular, | | |
Polymorphonuclear | 4 | 1 4.0|
Inflammation, Focal | | 1 1.0|
Mineralization | 1 1 | 7 1.1|
Nephropathy | 1 1 1 1 3 1 2 1 2 1 | 19 1.2|
Artery, Inflammation, Chronic | 3 2 | 2 2.5|
Renal Tubule, Degeneration, Hyaline | 3 | 1 3.0|
Renal Tubule, Dilatation | 2 | 1 2.0|
Renal Tubule, Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Urethra | + | 1 |
Bulbourethral Gland, Proliferation | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 4| 6| 7| 2| 5| 7| 4| 7| 7| 7| 6| 7| 2| 7| |
DAY ON TEST | 3| 3| 3| 5| 0| 6| 3| 3| 3| 3| 4| 5| 5| 3| 9| 3| 3| 7| 3| 1| 3| 6| 3| 2| 1| |
| 1| 1| 1| 3| 1| 8| 2| 2| 2| 2| 7| 6| 3| 2| 9| 5| 2| 0| 2| 5| 2| 5| 2| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Connective Tissue | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 4| 1| 1| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 2| 3| 3| 0| 2| 2| 2| 2| 8| 2|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| 9| 3| 9| 9| 2| 9| 8| 9| 9| 9| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.02% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Papillary | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + M M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + M + + + + + + + + + + + + + + M M + + + + + +|
Submucosa, Degeneration, Focal | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + M M + + + + + M|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst Multilocular | |
Eosinophilic Focus | |
Focal Cellular Change | |
Hemorrhage | 3 |
Inflammation, Focal | |
Necrosis, Focal | |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Suppurative | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Tooth | + + + |
Incisor, Dysplasia | 3 |
Incisor, Inflammation, Suppurative | 3 3 |
Molar, Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Abdominal, Inflammation, Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | 1 |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 4| 1| 1| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 2| 3| 3| 0| 2| 2| 2| 2| 8| 2|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| 9| 3| 9| 9| 2| 9| 8| 9| 9| 9| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.02% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + M + + + + + + + +|
Subcapsular, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M M + M + M + + + M|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 3 2 1 1 |
Inflammation, Focal | 1 |
Pigmentation | 1 2 |
Follicular Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + +|
Degeneration, Cystic | 1|
Inflammation, Suppurative | 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + M + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Hyperplasia | |
Inguinal, Angiectasis | 2 |
Inguinal, Hyperplasia | 3 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + M M M + + M M + + + + M + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +|
Angiectasis | 2 1 1 |
Pigmentation | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 4| 1| 1| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 2| 3| 3| 0| 2| 2| 2| 2| 8| 2|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| 9| 3| 9| 9| 2| 9| 8| 9| 9| 9| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.02% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 3 3 3 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + M + + + M M + + M M + + + + + + + + +|
Inflammation, Granulomatous | 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Inflammation, Chronic | 1 2 3 3 3 3 |
Ulcer | 3 3 |
Subcutaneous Tissue, Angiectasis | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
Subcutaneous Tissue, Mineralization | 2 |
Subcutaneous Tissue, Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 2 2 2 2 1 2 2 2 1 1 2 |
Meninges, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Hyperplasia, Lymphoid | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | 2 2 1 2 1 2 2 2 2 1 2 2|
Congestion | |
Hyperplasia, Lymphoid | 1 |
Hyperplasia, Macrophage | 2 |
Infiltration Cellular, | |
Polymorphonuclear | 3 2 2 |
Inflammation, Focal | 1 2 2 2 1 2 1 2 2 2 2 1 2 2|
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 |
Alveolar Epithelium, Metaplasia, | |
Focal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + M M + + + + + +|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 4| 1| 1| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 2| 3| 3| 0| 2| 2| 2| 2| 8| 2|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| 9| 3| 9| 9| 2| 9| 8| 9| 9| 9| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.02% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Adventitia, Inflammation, Focal | |
Lumen, Exudate | 2 2 |
Lumen, Foreign Body | 2 |
Mucosa, Inflammation, Suppurative | 2 2 3 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | +|
Duct, Dilatation, Focal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Congestion | 2 |
Cyst | X |
Hyperplasia, Lymphoid | 2 1 |
Mineralization | 2 1 1 1 1 1 1 1 1 2|
Nephropathy | 1 1 2 1 1 1 1 1 1 1 1 |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Vacuolization | |
Cytoplasmic | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 8| 2| 2| 2| 0| 2| 4| 0| 2| 2| 5| 1| 2| 2| 5| 0| 2| 0| 2| 1| 2| 3| 2| 2| |
| 9| 0| 9| 9| 9| 3| 9| 1| 3| 9| 9| 9| 1| 9| 9| 3| 2| 9| 2| 9| 0| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.02% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
Hyperplasia, Papillary | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + M + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Submucosa, Degeneration, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + M + + + + + + + + M + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 1| 2 2.0|
Cyst Multilocular | X | 1 |
Eosinophilic Focus | 2 | 1 2.0|
Focal Cellular Change | 2 | 1 2.0|
Hemorrhage | | 1 3.0|
Inflammation, Focal | 2 2 | 2 2.0|
Necrosis, Focal | 2 | 1 2.0|
Centrilobular, Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + +| 6 |
Inflammation, Suppurative | 1| 1 1.0|
Fat, Necrosis | 3 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pigmentation, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Tooth | + + + + | 7 |
Incisor, Dysplasia | 3 1 2 | 4 2.3|
Incisor, Inflammation, Suppurative | 1 3 4 | 5 2.8|
Molar, Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 8| 2| 2| 2| 0| 2| 4| 0| 2| 2| 5| 1| 2| 2| 5| 0| 2| 0| 2| 1| 2| 3| 2| 2| |
| 9| 0| 9| 9| 9| 3| 9| 1| 3| 9| 9| 9| 1| 9| 9| 3| 2| 9| 2| 9| 0| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.02% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Abdominal, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Focal | | 1 1.0|
Mineralization | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Subcapsular, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 2 2| 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X| 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 1 1 1 1 2 2 | 11 1.5|
Inflammation, Focal | | 1 1.0|
Pigmentation | | 2 1.5|
Follicular Cell, Hyperplasia | | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Penis | + | 1 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 7 |
Degeneration, Cystic | 3 3 1 1 | 5 1.8|
Inflammation, Suppurative | 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 2 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 3 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 8| 2| 2| 2| 0| 2| 4| 0| 2| 2| 5| 1| 2| 2| 5| 0| 2| 0| 2| 1| 2| 3| 2| 2| |
| 9| 0| 9| 9| 9| 3| 9| 1| 3| 9| 9| 9| 1| 9| 9| 3| 2| 9| 2| 9| 0| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.02% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Hyperplasia | 3 | 1 3.0|
Inguinal, Angiectasis | 1 | 2 1.5|
Inguinal, Hyperplasia | 1 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 43 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + M +| 47 |
Angiectasis | 2 3 3 3 2 2 1 2| 11 2.0|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 3 3 3 3 4 3 4 | 12 3.1|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + + M +| 43 |
Inflammation, Granulomatous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + M + M M M M M M M M M M M M M M M M M M M M| 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 3.0|
Inflammation, Chronic | 2 3 3 3 1 3 3 1 2| 15 2.4|
Ulcer | 3 | 3 3.0|
Subcutaneous Tissue, Angiectasis | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | 3 | 1 3.0|
Subcutaneous Tissue, Mineralization | | 1 2.0|
Subcutaneous Tissue, Ulcer | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 1 2 1 2 2 2 2 2 3 2 2 2 | 26 1.8|
Meninges, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Meninges, Hyperplasia, Lymphoid | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 8| 2| 2| 2| 0| 2| 4| 0| 2| 2| 5| 1| 2| 2| 5| 0| 2| 0| 2| 1| 2| 3| 2| 2| |
| 9| 0| 9| 9| 9| 3| 9| 1| 3| 9| 9| 9| 1| 9| 9| 3| 2| 9| 2| 9| 0| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.02% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenomatosis | 1 1 2 2 1 2 2 1 3 1 2 1| 24 1.7|
Congestion | 3 1 | 2 2.0|
Hyperplasia, Lymphoid | | 1 1.0|
Hyperplasia, Macrophage | 2 | 2 2.0|
Infiltration Cellular, | | |
Polymorphonuclear | 1 2 | 5 2.0|
Inflammation, Focal | 1 1 2 1 1 2 2 1 1 2 1| 25 1.6|
Inflammation, Suppurative | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 2 1.5|
Alveolar Epithelium, Metaplasia, | | |
Focal | 1 1 | 3 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Adventitia, Inflammation, Focal | 2 | 1 2.0|
Lumen, Exudate | | 2 2.0|
Lumen, Foreign Body | | 1 2.0|
Mucosa, Inflammation, Suppurative | | 4 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 4 |
Duct, Dilatation, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Autolysis | | 1 3.0|
Congestion | | 1 2.0|
Cyst | | 1 |
Hyperplasia, Lymphoid | | 2 1.5|
Mineralization | 1 1 2 1 1 1 1 | 17 1.2|
Nephropathy | 1 1 2 1 1 1 1 1 1 1 1 2 1 1| 25 1.1|
Renal Tubule, Dilatation | | 1 2.0|
Renal Tubule, Vacuolization | | |
Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 4| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 1| 5| 0| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.01% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + + M + + + + + + + M + + + + + + + M +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 3 3 |
Inflammation, Chronic | 3 3 |
Prolapse | 3 3 |
Ulcer | 3 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + M + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Fibrosis, Focal | 2 |
Hematopoietic Cell Proliferation | 2 |
Infarct | |
Mineralization, Focal | 3 |
Necrosis, Focal | 3 2 |
Necrosis, Multifocal | |
Pigmentation | 2 |
Vacuolization Cytoplasmic | 1 |
Bile Duct, Dilatation | |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + + |
Hyperplasia, Lymphoid | 1 |
Inflammation, Suppurative | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Papillary | 1 |
Inflammation, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Hyaline | 2 |
Mineralization | 2 2 |
__________________________________________________________________________|
Tooth | + + + + |
Incisor, Dysplasia | 2 2 4 2 |
Incisor, Inflammation, Suppurative | 3 3 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 4| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 1| 5| 0| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.01% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + M + + + + + M M + + + + + + + +|
Cyst, Multiple | |
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + M + + + + + +|
Cyst | X |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 2 1 1 1 |
Inflammation, Focal | 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + +|
Degeneration, Cystic | 1 2 2 4|
Inflammation, Suppurative | 4 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + |
Atrophy | 2 |
Dilatation | 3 |
Lumen, Crystals | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 4| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 1| 5| 0| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.01% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inguinal, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia | 1 |
Inguinal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + + + M M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M +|
Angiectasis | 1 1 2 1 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 2 4 3 3 3 3 3 3 |
Hyperplasia, Lymphoid | 2 |
Red Pulp, Depletion Cellular | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M + + + + + M|
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Fibrosis | 1 |
Hyperplasia, Basal Cell | |
Inflammation, Chronic | 1 2 1 2 2 1 3 3 1 3 3 |
Mineralization | |
Ulcer | 2 3 |
Lip, Inflammation, Suppurative | 2 |
Subcutaneous Tissue, Angiectasis | |
Subcutaneous Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Thigh, Mineralization | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 3 2 2 2 2 2 2 1 2 1 2 2 2 2 2|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sciatic, Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Hyperplasia, Lymphoid | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | 2 1 2 2 1 2 2 2 2 2 1 1 2 2 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 4| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| 3|
| 0| 0| 0| 0| 0| 1| 5| 0| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.01% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hemorrhage, Focal | 1 |
Hyperplasia, Macrophage | 1 1 1 |
Infiltration Cellular, | |
Polymorphonuclear | 3 |
Inflammation, Focal | 2 1 2 2 1 2 2 1 2 2 2 1 1 2 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 1 |
Alveolar Epithelium, Metaplasia, | |
Focal | 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adventitia, Inflammation, Suppurative| 2 |
Lumen, Exudate | 2 2 2 1 |
Lumen, Foreign Body | 2 1 |
Mucosa, Inflammation, Suppurative | 2 |
Nasolacrimal Duct, Foreign Body | 1 |
Nasolacrimal Duct, Inflammation | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + |
Duct, Dilatation, Focal | 2 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 3 |
Hyperplasia, Lymphoid | 1 1 1 1 1 1 |
Mineralization | 1 1 1 1 |
Nephropathy | 2 1 1 2 1 1 1 1 1 1 2 1 1 1 1 2 |
Pigmentation | 3 |
Capsule, Fibrosis, Focal | |
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urethra | |
Bulbourethral Gland, Degeneration, | |
Cystic | |
Bulbourethral Gland, Fibrosis, Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 1| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 6| 3| 3| 3| 1| 7| 3| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 0| 1| 1| 1| 1| 2| 6| 1| 1| 1| 7| 8| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.01% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + M + + M + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + + + + + + + + M + + + + + + + + M + M +| 42 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 |
Dysplasia | | 2 3.0|
Inflammation, Chronic | | 2 3.0|
Prolapse | | 2 3.0|
Ulcer | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + M + + + + M A +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + M + + M A +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Fibrosis, Focal | 3 | 2 2.5|
Hematopoietic Cell Proliferation | | 1 2.0|
Infarct | 4 | 1 4.0|
Mineralization, Focal | 3 | 2 3.0|
Necrosis, Focal | | 2 2.5|
Necrosis, Multifocal | 3 | 1 3.0|
Pigmentation | | 1 2.0|
Vacuolization Cytoplasmic | | 1 1.0|
Bile Duct, Dilatation | 3 2 | 2 2.5|
Bile Duct, Hyperplasia | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Hyperplasia, Lymphoid | | 1 1.0|
Inflammation, Suppurative | 3 | 1 3.0|
Fat, Necrosis | 4 | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Papillary | 3 | 2 2.0|
Inflammation, Focal | 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 1| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 6| 3| 3| 3| 1| 7| 3| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 0| 1| 1| 1| 1| 2| 6| 1| 1| 1| 7| 8| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.01% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Degeneration, Hyaline | | 1 2.0|
Mineralization | | 2 2.0|
__________________________________________________________________________|____________|
Tooth | + + + + | 8 |
Incisor, Dysplasia | 3 1 2 1 | 8 2.1|
Incisor, Inflammation, Suppurative | | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcapsular, Hyperplasia, Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + + + + M + + + + + + + + + + +| 44 |
Cyst, Multiple | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + M + + + + + +| 46 |
Cyst | | 1 |
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Degeneration, Cystic | 2 1 2 1 | 10 1.4|
Inflammation, Focal | | 1 2.0|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Penis | + | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 13 |
Degeneration, Cystic | 4 3 3 3 | 8 2.8|
Inflammation, Suppurative | 4 3 3 4 4 4 | 8 3.6|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 1| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 6| 3| 3| 3| 1| 7| 3| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 0| 1| 1| 1| 1| 2| 6| 1| 1| 1| 7| 8| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.01% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Atrophy | | 1 2.0|
Dilatation | | 1 3.0|
Lumen, Crystals | 4 | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Mineralization | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inguinal, Hyperplasia, Lymphoid | 2| 1 2.0|
Inguinal, Hyperplasia | 2 | 2 1.5|
Inguinal, Pigmentation | 1| 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + M M + + M + + + M +| 42 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
Angiectasis | 1 4 3 2 1 | 11 1.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Lymphoid | 4 | 1 4.0|
Hematopoietic Cell Proliferation | 3 3 3 3 | 12 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Red Pulp, Depletion Cellular | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + M M + + + + + M M + + + + + M M + + M + M +| 40 |
Depletion Lymphoid | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M + M M M M M M M M M M| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Fibrosis | 3 | 2 2.0|
Hyperplasia, Basal Cell | 2 | 1 2.0|
Inflammation, Chronic | 1 1 1 3 2 2 3 3 2 2 3 3 3 3 3 3 1 | 29 2.2|
Mineralization | 3 4 | 2 3.5|
Ulcer | 3 3 3 3 | 6 2.8|
Lip, Inflammation, Suppurative | | 1 2.0|
Subcutaneous Tissue, Angiectasis | 1 | 1 1.0|
Subcutaneous Tissue, Inflammation, | | |
Suppurative | 4| 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 1| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 6| 3| 3| 3| 1| 7| 3| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 0| 1| 1| 1| 1| 2| 6| 1| 1| 1| 7| 8| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.01% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Thigh, Mineralization | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 2 2 2 2 2 2 2 2 2 1 2 1 2| 31 1.9|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sciatic, Hyperplasia, Lymphoid | | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Meninges, Hyperplasia, Lymphoid | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenomatosis | 1 2 1 1 2 2 1 1 1 1 1 2 2 1| 28 1.5|
Hemorrhage, Focal | | 1 1.0|
Hyperplasia, Macrophage | | 3 1.0|
Infiltration Cellular, | | |
Polymorphonuclear | 2 | 2 2.5|
Inflammation, Focal | 1 2 1 1 2 2 1 1 1 1 1 2 1 1 2 1| 31 1.5|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 3 1.0|
Alveolar Epithelium, Metaplasia, | | |
Focal | 1 | 4 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Adventitia, Inflammation, Suppurative| | 1 2.0|
Lumen, Exudate | 1 1 1 1 1 1 1 1 1 1 1 1 2 | 17 1.2|
Lumen, Foreign Body | 1 1 1 1 1 1 1 1 1 1 1 | 13 1.1|
Mucosa, Inflammation, Suppurative | | 1 2.0|
Nasolacrimal Duct, Foreign Body | 1 | 2 1.0|
Nasolacrimal Duct, Inflammation | | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 6 |
Duct, Dilatation, Focal | 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05058-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ROXARSONE Date: 05/06/97
Route: DOSED FEED Time: 09:32:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 1| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 6| 3| 3| 3| 1| 7| 3| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 0| 1| 1| 1| 1| 2| 6| 1| 1| 1| 7| 8| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.01% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Hydronephrosis | | 1 3.0|
Hyperplasia, Lymphoid | 1 1 1 1| 10 1.0|
Mineralization | 1 1 1 1 1 | 9 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1| 29 1.1|
Pigmentation | | 1 3.0|
Capsule, Fibrosis, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urethra | + | 1 |
Bulbourethral Gland, Degeneration, | | |
Cystic | 4 | 1 4.0|
Bulbourethral Gland, Fibrosis, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 538868-538868/538868
--multipart-boundary--