TDMS Study 05058-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
ROXARSONE
NTP Experiment-Test: 05058-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/08/94
Route: DOSED FEED Time: 07:31:04
Facility: Southern Research Institute
Chemical CAS #: 121-19-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05058-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ROXARSONE Date: 09/08/94
Route: DOSED FEED Time: 07:31:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.005% 0.01%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund Sacrifice 22 12 16
Natural Death 1 3 2
Survivors
Terminal Sacrifice 27 35 32
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (47) (50)
Parasite Metazoan 1 (2%)
Intestine Large, Colon (49) (48) (49)
Cyst 1 (2%)
Parasite Metazoan 1 (2%) 1 (2%) 2 (4%)
Intestine Large, Rectum (49) (50) (48)
Parasite Metazoan 1 (2%) 3 (6%) 2 (4%)
Liver (50) (50) (50)
Angiectasis, Focal 1 (2%) 1 (2%) 4 (8%)
Basophilic Focus 2 (4%) 2 (4%) 4 (8%)
Basophilic Focus, Multiple 23 (46%) 30 (60%) 27 (54%)
Clear Cell Focus 1 (2%) 1 (2%) 1 (2%)
Congestion 1 (2%)
Degeneration, Cystic 1 (2%) 1 (2%)
Degeneration, Fatty, Multifocal 1 (2%)
Developmental Malformation 6 (12%) 6 (12%) 8 (16%)
Eosinophilic Focus 2 (4%)
Granuloma, Multifocal 25 (50%) 29 (58%) 31 (62%)
Hematopoietic Cell Proliferation 1 (2%)
Hepatodiaphragmatic Nodule 3 (6%) 1 (2%)
Hyperplasia, Focal 1 (2%)
Mixed Cell Focus 3 (6%) 1 (2%)
Necrosis, Multifocal 1 (2%) 2 (4%)
Regeneration 1 (2%)
Vacuolization Cytoplasmic, Diffuse 4 (8%) 2 (4%)
Vacuolization Cytoplasmic, Focal 3 (6%)
Biliary Tract, Proliferation 17 (34%) 12 (24%) 16 (32%)
Centrilobular, Necrosis 11 (22%) 9 (18%) 8 (16%)
Mesentery (10) (6) (3)
Cyst 1 (17%)
Mineralization, Multifocal 1 (10%)
Fat, Necrosis, Focal 8 (80%) 3 (50%) 3 (100%)
Fat, Necrosis, Multifocal 1 (10%)
Pancreas (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05058-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ROXARSONE Date: 09/08/94
Route: DOSED FEED Time: 07:31:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.005% 0.01%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Atrophy, Focal 11 (22%) 11 (22%) 14 (28%)
Basophilic Focus 1 (2%) 1 (2%)
Pharynx (2) (1)
Cyst 1 (50%)
Inflammation, Acute, Focal, Suppurative 1 (100%)
Salivary Glands (50) (47) (48)
Atrophy, Focal 1 (2%)
Stomach, Forestomach (50) (50) (50)
Cyst 1 (2%)
Edema 1 (2%)
Erosion 1 (2%)
Hyperkeratosis 3 (6%) 2 (4%)
Hyperplasia 1 (2%) 3 (6%) 2 (4%)
Inflammation, Chronic 1 (2%) 1 (2%)
Ulcer 1 (2%) 3 (6%) 2 (4%)
Stomach, Glandular (50) (50) (50)
Edema 3 (6%)
Erosion 1 (2%)
Inflammation, Chronic, Diffuse 1 (2%)
Ulcer 1 (2%) 1 (2%)
Tooth (2) (1)
Dysplasia 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Cardiomyopathy 35 (70%) 30 (60%) 32 (64%)
Artery, Inflammation, Chronic 1 (2%)
Atrium, Thrombosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50)
Cyst 1 (2%)
Degeneration, Fatty, Focal 6 (12%) 8 (16%) 13 (26%)
Degeneration, Fatty, Multifocal 4 (8%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Focal 1 (2%) 3 (6%)
Necrosis, Multifocal 1 (2%)
Adrenal Gland, Medulla (49) (48) (50)
Hematopoietic Cell Proliferation 2 (4%)
Hyperplasia, Focal 2 (4%) 1 (2%)
Necrosis, Multifocal 1 (2%)
Pituitary Gland (50) (49) (48)
Pars Distalis, Angiectasis 28 (56%) 29 (59%) 24 (50%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05058-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ROXARSONE Date: 09/08/94
Route: DOSED FEED Time: 07:31:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.005% 0.01%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Cyst 11 (22%) 6 (12%) 10 (21%)
Pars Distalis, Hemorrhage 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia, Focal 9 (18%) 6 (12%) 13 (27%)
Pars Distalis, Pigmentation, Hemosiderin 9 (18%) 1 (2%) 4 (8%)
Pars Distalis, Thrombosis 1 (2%)
Thyroid Gland (50) (50) (50)
C-Cell, Hyperplasia 2 (4%)
C-Cell, Hyperplasia, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (44) (47) (48)
Abscess 2 (5%) 1 (2%)
Hyperplasia 2 (5%) 7 (15%) 3 (6%)
Inflammation, Acute, Suppurative 1 (2%)
Inflammation, Chronic 1 (2%)
Duct, Cyst 4 (9%) 1 (2%) 5 (10%)
Duct, Hyperplasia 1 (2%)
Ovary (50) (47) (50)
Cyst 1 (2%) 2 (4%) 2 (4%)
Uterus (50) (49) (50)
Cyst 2 (4%)
Hemorrhage 1 (2%) 1 (2%)
Hydrometra 3 (6%)
Hyperplasia, Cystic 1 (2%) 1 (2%)
Inflammation, Acute, Suppurative 1 (2%)
Cervix, Abscess 6 (12%) 6 (12%) 3 (6%)
Cervix, Abscess, Multiple 1 (2%)
Cervix, Cyst 5 (10%) 7 (14%) 5 (10%)
Cervix, Cyst, Multiple 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (50) (50) (50)
Mediastinal, Congestion 1 (2%)
Mediastinal, Ectasia 1 (2%)
Lymph Node, Mandibular (49) (46) (49)
Congestion 1 (2%)
Ectasia 1 (2%) 2 (4%)
Spleen (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05058-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ROXARSONE Date: 09/08/94
Route: DOSED FEED Time: 07:31:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.005% 0.01%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 3 (6%) 2 (4%) 3 (6%)
Hyperplasia, Lymphoid 2 (4%)
Necrosis, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (49) (50)
Duct, Cyst 44 (88%) 47 (96%) 39 (78%)
Skin (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Hypertrophy, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Compression 7 (14%) 1 (2%) 1 (2%)
Hemorrhage, Multifocal 2 (4%) 1 (2%)
Lateral Ventricle, Dilatation 1 (2%)
Peripheral Nerve (50) (47) (50)
Infiltration Cellular, Mononuclear Cell 2 (4%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Congestion 1 (2%)
Fungus 1 (2%)
Granuloma, Multifocal 1 (2%)
Hemorrhage, Multifocal 1 (2%)
Infiltration Cellular, Multifocal, Histiocyte 1 (2%) 1 (2%)
Necrosis, Focal 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%) 1 (2%) 4 (8%)
Nose (50) (50) (50)
Foreign Body 2 (4%)
Fungus 3 (6%) 1 (2%)
Inflammation, Acute, Suppurative 3 (6%) 1 (2%)
Inflammation, Chronic 1 (2%)
Nasolacrimal Duct, Inflammation, Acute,
Suppurative 1 (2%) 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05058-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ROXARSONE Date: 09/08/94
Route: DOSED FEED Time: 07:31:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.005% 0.01%
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Olfactory Epithelium, Erosion 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (20) (5)
Cataract 2 (67%) 19 (95%) 3 (60%)
Anterior Chamber, Fibrosis 1 (20%)
Retina, Degeneration 2 (67%) 20 (100%) 4 (80%)
Harderian Gland (1)
Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Fibrosis, Focal 1 (2%) 1 (2%)
Hydronephrosis 1 (2%)
Nephropathy, Chronic 36 (72%) 36 (72%) 28 (56%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Degeneration, Multifocal 1 (2%)
Renal Tubule, Dilatation, Multifocal 1 (2%)
Urethra (1)
Calculus Gross Observation 1 (100%)
Inflammation, Acute, Suppurative 1 (100%)
Urinary Bladder (50) (50) (50)
Hemorrhage, Multifocal 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05058-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ROXARSONE Date: 09/08/94
Route: DOSED FEED Time: 07:31:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.005% 0.01%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund Sacrifice 22 25 27
Natural Death 4 7 5
Survivors
Terminal Sacrifice 24 18 18
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (48) (49) (49)
Inflammation, Chronic 1 (2%)
Intestine Large, Colon (50) (49) (49)
Inflammation, Chronic, Focal 1 (2%)
Mineralization, Multifocal 1 (2%) 2 (4%) 2 (4%)
Parasite Metazoan 3 (6%) 1 (2%)
Artery, Mineralization 1 (2%)
Intestine Large, Rectum (48) (50) (49)
Mineralization, Multifocal 1 (2%)
Parasite Metazoan 3 (6%) 3 (6%) 3 (6%)
Intestine Small, Jejunum (50) (50) (50)
Thrombosis 1 (2%)
Liver (50) (50) (50)
Angiectasis, Focal 11 (22%) 4 (8%) 6 (12%)
Angiectasis, Multifocal 2 (4%) 1 (2%)
Basophilic Focus 5 (10%) 1 (2%)
Basophilic Focus, Multiple 2 (4%) 5 (10%) 1 (2%)
Clear Cell Focus 5 (10%) 1 (2%) 4 (8%)
Clear Cell Focus, Multiple 1 (2%)
Degeneration, Cystic 4 (8%) 5 (10%) 1 (2%)
Developmental Malformation 7 (14%) 3 (6%) 2 (4%)
Eosinophilic Focus 1 (2%)
Granuloma, Multifocal 1 (2%) 5 (10%) 6 (12%)
Mixed Cell Focus 1 (2%) 2 (4%)
Necrosis, Multifocal 1 (2%) 1 (2%)
Regeneration 1 (2%) 1 (2%)
Vacuolization Cytoplasmic, Diffuse 1 (2%) 2 (4%)
Vacuolization Cytoplasmic, Focal 4 (8%) 1 (2%)
Artery, Mineralization 1 (2%)
Biliary Tract, Proliferation 40 (80%) 33 (66%) 40 (80%)
Centrilobular, Necrosis 14 (28%) 20 (40%) 16 (32%)
Serosa, Inflammation, Acute, Focal,
Suppurative 1 (2%)
Mesentery (2) (4) (6)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05058-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ROXARSONE Date: 09/08/94
Route: DOSED FEED Time: 07:31:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.005% 0.01%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mineralization, Multifocal 1 (50%)
Fat, Necrosis, Focal 2 (100%) 2 (50%) 4 (67%)
Fat, Necrosis, Multifocal 1 (25%)
Pancreas (50) (50) (50)
Atrophy, Focal 22 (44%) 27 (54%) 22 (44%)
Basophilic Focus 3 (6%)
Fibrosis, Focal 1 (2%)
Hyperplasia, Focal 2 (4%) 3 (6%)
Artery, Inflammation, Chronic 1 (2%)
Artery, Mineralization, Multifocal 1 (2%) 1 (2%) 1 (2%)
Artery, Thrombosis 1 (2%) 1 (2%)
Stomach (50) (50) (50)
Artery, Inflammation, Chronic 1 (2%)
Artery, Mineralization, Diffuse 1 (2%)
Stomach, Forestomach (50) (50) (50)
Edema 1 (2%) 1 (2%)
Hyperkeratosis 3 (6%) 3 (6%)
Hyperplasia 1 (2%) 4 (8%) 3 (6%)
Inflammation, Acute, Suppurative 1 (2%) 2 (4%)
Inflammation, Chronic 1 (2%) 1 (2%) 2 (4%)
Mineralization, Diffuse 3 (6%) 4 (8%) 5 (10%)
Perforation 1 (2%) 2 (4%)
Ulcer 2 (4%) 2 (4%) 2 (4%)
Ulcer, Multiple 1 (2%)
Stomach, Glandular (50) (50) (50)
Edema 1 (2%) 4 (8%) 1 (2%)
Erosion 1 (2%) 2 (4%)
Inflammation, Chronic, Diffuse 2 (4%)
Mineralization, Diffuse 4 (8%) 6 (12%) 8 (16%)
Ulcer 1 (2%)
Ulcer, Multiple 1 (2%) 1 (2%)
Tongue (3)
Hyperkeratosis, Focal 1 (33%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (3) (5) (6)
Aorta, Mineralization, Diffuse 3 (100%) 5 (100%) 6 (100%)
Heart (50) (50) (50)
Cardiomyopathy 44 (88%) 46 (92%) 45 (90%)
Mineralization, Multifocal 2 (4%) 4 (8%) 5 (10%)
Atrium, Thrombosis 2 (4%) 3 (6%) 4 (8%)
Endocardium, Inflammation, Chronic, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05058-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ROXARSONE Date: 09/08/94
Route: DOSED FEED Time: 07:31:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.005% 0.01%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50)
Accessory Adrenal Cortical Nodule 3 (6%)
Degeneration, Fatty, Focal 9 (18%) 10 (20%) 15 (30%)
Degeneration, Fatty, Multifocal 1 (2%)
Hyperplasia, Focal 1 (2%) 2 (4%)
Adrenal Gland, Medulla (50) (49) (50)
Hyperplasia, Focal 10 (20%) 1 (2%) 10 (20%)
Mineralization, Multifocal 1 (2%)
Islets, Pancreatic (50) (50) (50)
Hyperplasia, Focal 1 (2%)
Parathyroid Gland (46) (47) (45)
Hyperplasia 3 (7%) 9 (19%) 9 (20%)
Pituitary Gland (50) (48) (48)
Pars Distalis, Angiectasis 9 (18%) 12 (25%) 7 (15%)
Pars Distalis, Cyst 4 (8%) 1 (2%) 1 (2%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia, Focal 8 (16%) 11 (23%) 6 (13%)
Pars Distalis, Pigmentation, Hemosiderin 1 (2%) 1 (2%)
Thyroid Gland (50) (50) (50)
C-Cell, Hyperplasia 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ductus Deferens (2) (2)
Mineralization, Diffuse 2 (100%) 2 (100%)
Preputial Gland (49) (48) (48)
Foreign Body 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Acute, Suppurative 9 (18%) 5 (10%) 2 (4%)
Inflammation, Chronic 2 (4%) 1 (2%)
Duct, Cyst 8 (16%) 4 (8%) 3 (6%)
Prostate (50) (50) (50)
Cyst 1 (2%)
Inflammation, Acute, Suppurative 17 (34%) 13 (26%) 17 (34%)
Seminal Vesicle (3) (5) (3)
Dilatation 1 (33%)
Hyperplasia 1 (33%)
Testes (50) (50) (50)
Atrophy 16 (32%) 16 (32%) 17 (34%)
Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05058-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ROXARSONE Date: 09/08/94
Route: DOSED FEED Time: 07:31:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.005% 0.01%
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Mineralization, Focal 1 (2%)
Arteriole, Inflammation, Chronic 1 (2%)
Artery, Mineralization 1 (2%)
Interstitial Cell, Hyperplasia 3 (6%) 5 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Hyperplasia 1 (2%)
Hypoplasia 1 (2%) 1 (2%)
Lymph Node (50) (50) (50)
Iliac, Hyperplasia 1 (2%)
Inguinal, Hyperplasia 2 (4%) 1 (2%)
Mediastinal, Ectasia 3 (6%)
Mediastinal, Pigmentation 1 (2%) 1 (2%)
Pancreatic, Ectasia 1 (2%) 1 (2%)
Renal, Congestion 1 (2%)
Renal, Ectasia 1 (2%) 1 (2%)
Lymph Node, Mandibular (50) (50) (48)
Ectasia 14 (28%) 5 (10%) 4 (8%)
Hyperplasia 3 (6%) 1 (2%) 1 (2%)
Lymph Node, Mesenteric (50) (49) (48)
Congestion 1 (2%) 1 (2%)
Ectasia 1 (2%) 2 (4%) 2 (4%)
Spleen (50) (50) (50)
Atrophy 1 (2%)
Developmental Malformation 2 (4%)
Fibrosis, Diffuse 1 (2%)
Fibrosis, Focal 2 (4%) 6 (12%) 6 (12%)
Hematopoietic Cell Proliferation 9 (18%) 6 (12%) 6 (12%)
Hyperplasia, Focal 2 (4%)
Mineralization, Focal 1 (2%)
Necrosis, Focal 1 (2%)
Necrosis, Multifocal 1 (2%)
Capsule, Fibrosis, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (47) (49) (49)
Duct, Cyst 12 (26%) 14 (29%) 10 (20%)
Skin (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%) 2 (4%)
Foreign Body 2 (4%) 2 (4%)
Hyperkeratosis, Focal 2 (4%) 1 (2%)
Hyperplasia, Focal 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05058-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ROXARSONE Date: 09/08/94
Route: DOSED FEED Time: 07:31:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.005% 0.01%
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Inflammation, Acute, Focal, Suppurative 1 (2%) 3 (6%)
Inflammation, Acute, Multifocal, Suppurative 1 (2%)
Inflammation, Chronic, Focal 2 (4%) 1 (2%)
Inflammation, Focal, Granulomatous 3 (6%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Fibrous Osteodystrophy 3 (6%) 5 (10%) 8 (16%)
Hypertrophy, Focal 1 (2%)
Skeletal Muscle (1) (2)
Mineralization, Multifocal 2 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (49)
Compression 2 (4%) 2 (4%)
Hemorrhage, Focal 1 (2%)
Hemorrhage, Multifocal 1 (2%) 1 (2%) 2 (4%)
Spinal Cord (50) (50) (50)
Hemorrhage, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Congestion 2 (4%)
Foreign Body 1 (2%)
Granuloma, Multifocal 1 (2%)
Hemorrhage, Multifocal 1 (2%) 1 (2%) 4 (8%)
Infiltration Cellular, Multifocal, Histiocyte 2 (4%) 1 (2%) 3 (6%)
Inflammation, Acute, Multifocal, Suppurative 1 (2%)
Mineralization, Multifocal 3 (6%) 5 (10%) 5 (10%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%) 2 (4%) 1 (2%)
Nose (49) (50) (49)
Foreign Body 5 (10%) 3 (6%)
Fungus 6 (12%) 2 (4%) 4 (8%)
Inflammation, Acute, Suppurative 6 (12%) 2 (4%) 6 (12%)
Mucosa, Cyst 1 (2%)
Nasolacrimal Duct, Foreign Body 2 (4%) 1 (2%) 1 (2%)
Nasolacrimal Duct, Inflammation, Acute,
Suppurative 3 (6%) 2 (4%) 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05058-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ROXARSONE Date: 09/08/94
Route: DOSED FEED Time: 07:31:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.005% 0.01%
CONTROL
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (6) (25)
Cataract 2 (50%) 1 (17%) 21 (84%)
Hemorrhage 2 (8%)
Hyperplasia 1 (4%)
Cornea, Inflammation, Acute, Suppurative 1 (17%)
Retina, Degeneration 3 (75%) 2 (33%) 23 (92%)
Harderian Gland (1)
Inflammation, Chronic, Focal 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Mineralization, Diffuse 3 (6%) 4 (8%) 4 (8%)
Nephropathy, Chronic 50 (100%) 49 (98%) 49 (98%)
Cortex, Cyst 5 (10%) 9 (18%) 8 (16%)
Renal Tubule, Pigmentation, Multifocal 1 (2%)
Urinary Bladder (50) (50) (50)
Hemorrhage, Multifocal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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